TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
Control vs Stop Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 009 1000 PPM
Include 010 1000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Early Deaths
Moribund Sacrifice 15 17
Natural Death 7 5
Survivors
Terminal Sacrifice 28 28
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50)
Inflammation, Suppurative 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (50) (50)
Parasite Metazoan 2 (4%) 4 (8%)
Intestine Small, Jejunum (50) (50)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (50) (50)
Parasite Metazoan 1 (2%)
Liver (50) (50)
Basophilic Focus 41 (82%) 34 (68%)
Clear Cell Focus 11 (22%) 16 (32%)
Eosinophilic Focus 2 (4%) 2 (4%)
Hepatodiaphragmatic Nodule 9 (18%) 10 (20%)
Inflammation, Chronic 31 (62%) 36 (72%)
Mixed Cell Focus 7 (14%) 5 (10%)
Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Thrombosis 2 (4%)
Bile Duct, Hyperplasia 24 (48%) 18 (36%)
Hepatocyte, Necrosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 9 (18%)
Hepatocyte, Centrilobular, Degeneration 2 (4%)
Hepatocyte, Centrilobular, Necrosis 2 (4%)
Kupffer Cell, Hypertrophy 1 (2%)
Mesentery (8) (6)
Accessory Spleen 1 (13%)
Artery, Inflammation, Chronic Active 1 (13%)
Fat, Necrosis 3 (38%) 3 (50%)
Oral Mucosa (1) (2)
Pharyngeal, Hyperplasia 1 (50%)
Pancreas (50) (50)
Cyst 1 (2%)
Acinus, Atrophy 10 (20%) 13 (26%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (50)
Inflammation, Chronic Active 1 (2%)
Epithelium, Hyperplasia 3 (6%) 4 (8%)
Epithelium, Ulcer 2 (4%)
Stomach, Glandular (50) (50)
Epithelium, Erosion 1 (2%)
Epithelium, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50)
Aorta, Inflammation, Chronic Active 1 (2%)
Heart (50) (50)
Cardiomyopathy, Chronic 27 (54%) 25 (50%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%)
Degeneration, Cystic 2 (4%)
Degeneration, Fatty 9 (18%) 14 (28%)
Hyperplasia 7 (14%) 17 (34%)
Hypertrophy 1 (2%) 3 (6%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Adrenal Medulla (50) (50)
Hyperplasia 3 (6%) 4 (8%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (46) (45)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50)
Necrosis 1 (2%)
Pars Distalis, Cyst 35 (70%) 24 (48%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 24 (48%) 24 (48%)
Pars Intermedia, Cyst 1 (2%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Ectopic Tissue 1 (2%)
Thyroid Gland (50) (50)
C-Cell, Hyperplasia 16 (32%) 17 (34%)
Follicular Cell, Hyperplasia, Cystic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49)
Hyperplasia 10 (20%) 10 (20%)
Inflammation, Chronic Active 4 (8%) 3 (6%)
Duct, Cyst 1 (2%)
Ovary (50) (50)
Cyst 3 (6%) 6 (12%)
Bilateral, Cyst 1 (2%) 1 (2%)
Uterus (50) (50)
Endometrium, Hyperplasia, Cystic 1 (2%)
Vagina (2)
Hypertrophy 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49)
Hyperplasia 11 (22%) 16 (33%)
Myelofibrosis 1 (2%)
Lymph Node (35) (30)
Mediastinal, Pigmentation, Hemosiderin 30 (86%) 26 (87%)
Renal, Ectasia 1 (3%)
Renal, Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mandibular (50) (50)
Ectasia 1 (2%)
Spleen (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 9 (18%) 7 (14%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50)
Cyst 2 (4%)
Hyperplasia, Cystic 43 (86%) 45 (90%)
Skin (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Epidermis, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49)
Osteopetrosis 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 12 (24%) 15 (30%)
Alveolar Epithelium, Hyperplasia 5 (10%) 5 (10%)
Alveolus, Infiltration Cellular, Histiocyte 41 (82%) 46 (92%)
Nose (50) (50)
Fungus 6 (12%) 2 (4%)
Inflammation, Chronic Active 13 (26%) 7 (14%)
Nasolacrimal Duct, Inflammation, Suppurative 9 (18%) 10 (20%)
Respiratory Epithelium, Hyperplasia 10 (20%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2)
Atrophy 2 (67%) 1 (50%)
Anterior Chamber, Cornea, Inflammation,
Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%)
Nephropathy, Chronic 44 (88%) 49 (98%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation 48 (96%) 49 (98%)
Urinary Bladder (50) (49)
Calculus Gross Observation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Early Deaths
Moribund Sacrifice 28 17
Natural Death 10 6
Survivors
Natural Death 1
Terminal Sacrifice 11 27
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49)
Parasite Metazoan 1 (2%) 3 (6%)
Ulcer 1 (2%)
Intestine Large, Rectum (50) (50)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%) 5 (10%)
Intestine Small, Duodenum (50) (50)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Epithelium, Erosion 1 (2%)
Intestine Small, Jejunum (49) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (49) (49)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50)
Angiectasis 2 (4%) 2 (4%)
Basophilic Focus 17 (34%) 31 (62%)
Clear Cell Focus 6 (12%) 9 (18%)
Eosinophilic Focus 2 (4%) 7 (14%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%)
Inflammation, Chronic 22 (44%) 34 (68%)
Mixed Cell Focus 1 (2%) 5 (10%)
Pigmentation, Bile 1 (2%)
Bile Duct, Hyperplasia 49 (98%) 46 (92%)
Hepatocyte, Degeneration, Cystic 16 (32%) 28 (56%)
Hepatocyte, Necrosis 3 (6%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 10 (20%) 13 (26%)
Hepatocyte, Centrilobular, Degeneration 2 (4%) 2 (4%)
Hepatocyte, Centrilobular, Hypertrophy 1 (2%)
Hepatocyte, Centrilobular, Necrosis 2 (4%) 2 (4%)
Kupffer Cell, Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (15) (15)
Inflammation, Chronic Active 1 (7%)
Fat, Necrosis 12 (80%) 11 (73%)
Pancreas (50) (50)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 12 (24%) 19 (38%)
Artery, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50)
Inflammation, Chronic Active 10 (20%) 2 (4%)
Epithelium, Hyperplasia 8 (16%) 4 (8%)
Epithelium, Ulcer 8 (16%) 1 (2%)
Stomach, Glandular (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Epithelium, Erosion 2 (4%) 1 (2%)
Epithelium, Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50)
Aorta, Mineralization 1 (2%) 2 (4%)
Pulmonary Artery, Thrombosis 1 (2%)
Heart (50) (50)
Cardiomyopathy, Chronic 42 (84%) 45 (90%)
Mineralization 1 (2%)
Atrium, Thrombosis 7 (14%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Fatty 28 (56%) 25 (50%)
Hyperplasia 13 (26%) 17 (34%)
Hypertrophy 3 (6%)
Necrosis 1 (2%)
Adrenal Medulla (50) (50)
Hyperplasia 18 (36%) 28 (56%)
Islets, Pancreatic (50) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (47) (47)
Hyperplasia 9 (19%) 7 (15%)
Pituitary Gland (50) (50)
Craniopharyngeal Duct, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 7 (14%) 6 (12%)
Pars Distalis, Hyperplasia 22 (44%) 26 (52%)
Thyroid Gland (50) (50)
C-Cell, Hyperplasia 16 (32%) 17 (34%)
Follicular Cell, Hyperplasia, Cystic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2)
Inflammation, Chronic Active 2 (100%)
Epididymis (50) (50)
Granuloma Sperm 1 (2%)
Preputial Gland (50) (49)
Hyperplasia 7 (14%) 8 (16%)
Inflammation, Chronic Active 42 (84%) 44 (90%)
Duct, Cyst 2 (4%)
Prostate (50) (50)
Inflammation, Chronic Active 38 (76%) 37 (74%)
Seminal Vesicle (50) (50)
Inflammation, Chronic Active 1 (2%)
Testes (50) (50)
Arteriole, Inflammation, Chronic 1 (2%) 1 (2%)
Arteriole, Necrosis, Fibrinoid 1 (2%)
Germinal Epithelium, Atrophy 2 (4%) 4 (8%)
Interstitial Cell, Hyperplasia 10 (20%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Hyperplasia 30 (60%) 38 (76%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (34) (28)
Inguinal, Inflammation, Suppurative 1 (4%)
Mediastinal, Ectasia 1 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (4%)
Mediastinal, Inflammation, Granulomatous 1 (4%)
Mediastinal, Pigmentation, Hemosiderin 25 (74%) 24 (86%)
Renal, Hyperplasia, Lymphoid 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (50) (50)
Ectasia 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (50) (50)
Ectasia 6 (12%)
Erythrophagocytosis 1 (2%)
Hyperplasia, Lymphoid 3 (6%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (50)
Fibrosis 5 (10%) 6 (12%)
Hematopoietic Cell Proliferation 4 (8%) 3 (6%)
Necrosis 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49)
Cyst 2 (4%)
Hyperplasia, Cystic 36 (73%) 26 (53%)
Inflammation, Suppurative 1 (2%)
Skin (50) (50)
Cyst Epithelial Inclusion 2 (4%)
Inflammation, Chronic Active 1 (2%)
Epidermis, Hyperkeratosis 4 (8%)
Epidermis, Hyperplasia 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Fibrous Osteodystrophy 1 (2%) 3 (6%)
Cranium, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Hemorrhage 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:32:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Foreign Body 1 (2%)
Inflammation, Chronic Active 3 (6%) 6 (12%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 39 (78%) 44 (88%)
Interstitium, Mineralization 1 (2%)
Nose (50) (50)
Fungus 21 (42%) 7 (14%)
Inflammation, Chronic Active 25 (50%) 21 (42%)
Nasolacrimal Duct, Inflammation, Suppurative 6 (12%) 4 (8%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 24 (48%) 11 (22%)
Respiratory Epithelium, Metaplasia, Squamous 12 (24%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3)
Lens, Cataract 1 (100%) 3 (100%)
Retina, Atrophy 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Cyst 1 (2%) 3 (6%)
Nephropathy, Chronic 50 (100%) 49 (98%)
Renal Tubule, Hyperplasia 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 49 (98%) 47 (94%)
Urinary Bladder (48) (49)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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