National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6131

TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 11:32:01

                                                     Control vs Stop Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 009    1000 PPM
                               Include 010    1000 PPM






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           17                                                               
    Natural Death                                      7            5                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           28                                                               

  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)                                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)                                                             
      Parasite Metazoan                                2 (4%)       4 (8%)                                                          
   Intestine Small, Jejunum                           (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Basophilic Focus                                41 (82%)     34 (68%)                                                         
      Clear Cell Focus                                11 (22%)     16 (32%)                                                         
      Eosinophilic Focus                               2 (4%)       2 (4%)                                                          
      Hepatodiaphragmatic Nodule                       9 (18%)     10 (20%)                                                         
      Inflammation, Chronic                           31 (62%)     36 (72%)                                                         
      Mixed Cell Focus                                 7 (14%)      5 (10%)                                                         
      Pigmentation, Hemosiderin                        1 (2%)       2 (4%)                                                          
      Thrombosis                                       2 (4%)                                                                       
      Bile Duct, Hyperplasia                          24 (48%)     18 (36%)                                                         
      Hepatocyte, Necrosis                                          1 (2%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)      9 (18%)                                                         
      Hepatocyte, Centrilobular, Degeneration                       2 (4%)                                                          
      Hepatocyte, Centrilobular, Necrosis              2 (4%)                                                                       
      Kupffer Cell, Hypertrophy                                     1 (2%)                                                          
   Mesentery                                          (8)          (6)                                                              
      Accessory Spleen                                 1 (13%)                                                                      
      Artery, Inflammation, Chronic Active             1 (13%)                                                                      
      Fat, Necrosis                                    3 (38%)      3 (50%)                                                         
   Oral Mucosa                                        (1)          (2)                                                              
      Pharyngeal, Hyperplasia                                       1 (50%)                                                         
   Pancreas                                           (50)         (50)                                                             
      Cyst                                                          1 (2%)                                                          
      Acinus, Atrophy                                 10 (20%)     13 (26%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (50)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)                                                          
      Epithelium, Ulcer                                2 (4%)                                                                       
   Stomach, Glandular                                 (50)         (50)                                                             
      Epithelium, Erosion                              1 (2%)                                                                       
      Epithelium, Ulcer                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)                                                             
      Aorta, Inflammation, Chronic Active              1 (2%)                                                                       
   Heart                                              (50)         (50)                                                             
      Cardiomyopathy, Chronic                         27 (54%)     25 (50%)                                                         
      Atrium, Thrombosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                                          2 (4%)                                                          
      Degeneration, Fatty                              9 (18%)     14 (28%)                                                         
      Hyperplasia                                      7 (14%)     17 (34%)                                                         
      Hypertrophy                                      1 (2%)       3 (6%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                     1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)                                                             
      Hyperplasia                                      3 (6%)       4 (8%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (46)         (45)                                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)                                                             
      Necrosis                                         1 (2%)                                                                       
      Pars Distalis, Cyst                             35 (70%)     24 (48%)                                                         
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      24 (48%)     24 (48%)                                                         
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)                                                          
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
      Pars Nervosa, Ectopic Tissue                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)                                                             
      C-Cell, Hyperplasia                             16 (32%)     17 (34%)                                                         
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)                                                             
      Hyperplasia                                     10 (20%)     10 (20%)                                                         
      Inflammation, Chronic Active                     4 (8%)       3 (6%)                                                          
      Duct, Cyst                                       1 (2%)                                                                       
   Ovary                                              (50)         (50)                                                             
      Cyst                                             3 (6%)       6 (12%)                                                         
      Bilateral, Cyst                                  1 (2%)       1 (2%)                                                          
   Uterus                                             (50)         (50)                                                             
      Endometrium, Hyperplasia, Cystic                              1 (2%)                                                          
   Vagina                                             (2)                                                                           
      Hypertrophy                                      1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)                                                             
      Hyperplasia                                     11 (22%)     16 (33%)                                                         
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (35)         (30)                                                             
      Mediastinal, Pigmentation, Hemosiderin          30 (86%)     26 (87%)                                                         
      Renal, Ectasia                                                1 (3%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (3%)                                                          
   Lymph Node, Mandibular                             (50)         (50)                                                             
      Ectasia                                          1 (2%)                                                                       
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)      7 (14%)                                                         
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)                                                             
      Cyst                                             2 (4%)                                                                       
      Hyperplasia, Cystic                             43 (86%)     45 (90%)                                                         
   Skin                                               (50)         (50)                                                             
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Epidermis, Hyperplasia                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)                                                             
      Osteopetrosis                                    6 (12%)      2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Hemorrhage                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                    12 (24%)     15 (30%)                                                         
      Alveolar Epithelium, Hyperplasia                 5 (10%)      5 (10%)                                                         
      Alveolus, Infiltration Cellular, Histiocyte     41 (82%)     46 (92%)                                                         
   Nose                                               (50)         (50)                                                             
      Fungus                                           6 (12%)      2 (4%)                                                          
      Inflammation, Chronic Active                    13 (26%)      7 (14%)                                                         
      Nasolacrimal Duct, Inflammation, Suppurative     9 (18%)     10 (20%)                                                         
      Respiratory Epithelium, Hyperplasia             10 (20%)      2 (4%)                                                          
      Respiratory Epithelium, Metaplasia, Squamous     3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)                                                              
      Atrophy                                          2 (67%)      1 (50%)                                                         
      Anterior Chamber, Cornea, Inflammation,                                                                                       
          Chronic Active                                            1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Cyst                                             1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Nephropathy, Chronic                            44 (88%)     49 (98%)                                                         
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Pigmentation                      48 (96%)     49 (98%)                                                         
   Urinary Bladder                                    (50)         (49)                                                             
      Calculus Gross Observation                                    1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           17                                                               
    Natural Death                                     10            6                                                               
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                11           27                                                               

  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (49)                                                             
      Parasite Metazoan                                1 (2%)       3 (6%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       5 (10%)                                                         
   Intestine Small, Duodenum                          (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Erosion                              1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Intestine Small, Ileum                             (49)         (49)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
      Angiectasis                                      2 (4%)       2 (4%)                                                          
      Basophilic Focus                                17 (34%)     31 (62%)                                                         
      Clear Cell Focus                                 6 (12%)      9 (18%)                                                         
      Eosinophilic Focus                               2 (4%)       7 (14%)                                                         
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                                    5 (10%)                                                         
      Inflammation, Chronic                           22 (44%)     34 (68%)                                                         
      Mixed Cell Focus                                 1 (2%)       5 (10%)                                                         
      Pigmentation, Bile                                            1 (2%)                                                          
      Bile Duct, Hyperplasia                          49 (98%)     46 (92%)                                                         
      Hepatocyte, Degeneration, Cystic                16 (32%)     28 (56%)                                                         
      Hepatocyte, Necrosis                             3 (6%)       2 (4%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic           10 (20%)     13 (26%)                                                         
      Hepatocyte, Centrilobular, Degeneration          2 (4%)       2 (4%)                                                          
      Hepatocyte, Centrilobular, Hypertrophy                        1 (2%)                                                          
      Hepatocyte, Centrilobular, Necrosis              2 (4%)       2 (4%)                                                          
      Kupffer Cell, Hypertrophy                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (15)         (15)                                                             
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Fat, Necrosis                                   12 (80%)     11 (73%)                                                         
   Pancreas                                           (50)         (50)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                 12 (24%)     19 (38%)                                                         
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)                                                             
      Inflammation, Chronic Active                    10 (20%)      2 (4%)                                                          
      Epithelium, Hyperplasia                          8 (16%)      4 (8%)                                                          
      Epithelium, Ulcer                                8 (16%)      1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)                                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)                                                          
      Epithelium, Erosion                              2 (4%)       1 (2%)                                                          
      Epithelium, Ulcer                                1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)                                                             
      Aorta, Mineralization                            1 (2%)       2 (4%)                                                          
      Pulmonary Artery, Thrombosis                     1 (2%)                                                                       
   Heart                                              (50)         (50)                                                             
      Cardiomyopathy, Chronic                         42 (84%)     45 (90%)                                                         
      Mineralization                                                1 (2%)                                                          
      Atrium, Thrombosis                               7 (14%)      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
      Accessory Adrenal Cortical Nodule                             2 (4%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)       1 (2%)                                                          
      Degeneration, Fatty                             28 (56%)     25 (50%)                                                         
      Hyperplasia                                     13 (26%)     17 (34%)                                                         
      Hypertrophy                                                   3 (6%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)                                                             
      Hyperplasia                                     18 (36%)     28 (56%)                                                         
   Islets, Pancreatic                                 (50)         (50)                                                             
      Hyperplasia                                      2 (4%)                                                                       
   Parathyroid Gland                                  (47)         (47)                                                             
      Hyperplasia                                      9 (19%)      7 (15%)                                                         
   Pituitary Gland                                    (50)         (50)                                                             
      Craniopharyngeal Duct, Cyst                      1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              7 (14%)      6 (12%)                                                         
      Pars Distalis, Hyperplasia                      22 (44%)     26 (52%)                                                         
   Thyroid Gland                                      (50)         (50)                                                             
      C-Cell, Hyperplasia                             16 (32%)     17 (34%)                                                         
      Follicular Cell, Hyperplasia, Cystic             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)                                                                           
      Inflammation, Chronic Active                     2 (100%)                                                                     
   Epididymis                                         (50)         (50)                                                             
      Granuloma Sperm                                               1 (2%)                                                          
   Preputial Gland                                    (50)         (49)                                                             
      Hyperplasia                                      7 (14%)      8 (16%)                                                         
      Inflammation, Chronic Active                    42 (84%)     44 (90%)                                                         
      Duct, Cyst                                       2 (4%)                                                                       
   Prostate                                           (50)         (50)                                                             
      Inflammation, Chronic Active                    38 (76%)     37 (74%)                                                         
   Seminal Vesicle                                    (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Testes                                             (50)         (50)                                                             
      Arteriole, Inflammation, Chronic                 1 (2%)       1 (2%)                                                          
      Arteriole, Necrosis, Fibrinoid                                1 (2%)                                                          
      Germinal Epithelium, Atrophy                     2 (4%)       4 (8%)                                                          
      Interstitial Cell, Hyperplasia                  10 (20%)      8 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Hyperplasia                                     30 (60%)     38 (76%)                                                         
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (34)         (28)                                                             
      Inguinal, Inflammation, Suppurative                           1 (4%)                                                          
      Mediastinal, Ectasia                                          1 (4%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (4%)                                                          
      Mediastinal, Inflammation, Granulomatous                      1 (4%)                                                          
      Mediastinal, Pigmentation, Hemosiderin          25 (74%)     24 (86%)                                                         
      Renal, Hyperplasia, Lymphoid                                  1 (4%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (50)         (50)                                                             
      Ectasia                                                       1 (2%)                                                          
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)                                                             
      Ectasia                                                       6 (12%)                                                         
      Erythrophagocytosis                                           1 (2%)                                                          
      Hyperplasia, Lymphoid                                         3 (6%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         5 (10%)      6 (12%)                                                         
      Hematopoietic Cell Proliferation                 4 (8%)       3 (6%)                                                          
      Necrosis                                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)                                                             
      Cyst                                                          2 (4%)                                                          
      Hyperplasia, Cystic                             36 (73%)     26 (53%)                                                         
      Inflammation, Suppurative                                     1 (2%)                                                          
   Skin                                               (50)         (50)                                                             
      Cyst Epithelial Inclusion                                     2 (4%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Epidermis, Hyperkeratosis                                     4 (8%)                                                          
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Fibrous Osteodystrophy                           1 (2%)       3 (6%)                                                          
      Cranium, Inflammation, Chronic Active                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Hemorrhage                                       4 (8%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:32:01  
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         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)       6 (12%)                                                         
      Alveolar Epithelium, Hyperplasia                 1 (2%)       3 (6%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte     39 (78%)     44 (88%)                                                         
      Interstitium, Mineralization                                  1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
      Fungus                                          21 (42%)      7 (14%)                                                         
      Inflammation, Chronic Active                    25 (50%)     21 (42%)                                                         
      Nasolacrimal Duct, Inflammation, Suppurative     6 (12%)      4 (8%)                                                          
      Olfactory Epithelium, Metaplasia, Squamous                    1 (2%)                                                          
      Respiratory Epithelium, Hyperplasia             24 (48%)     11 (22%)                                                         
      Respiratory Epithelium, Metaplasia, Squamous    12 (24%)      5 (10%)                                                         
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)                                                              
      Lens, Cataract                                   1 (100%)     3 (100%)                                                        
      Retina, Atrophy                                  1 (100%)     3 (100%)                                                        
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Cyst                                             1 (2%)       3 (6%)                                                          
      Nephropathy, Chronic                            50 (100%)    49 (98%)                                                         
      Renal Tubule, Hyperplasia                        1 (2%)       2 (4%)                                                          
      Renal Tubule, Pigmentation                      49 (98%)     47 (94%)                                                         
   Urinary Bladder                                    (48)         (49)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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