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TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 11:03:46

                                                           Core Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 003    200 PPM
                               Include 004    200 PPM
                               Include 005    400 PPM
                               Include 006    400 PPM
                               Include 007    600 PPM
                               Include 008    600 PPM


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           12           12           17                                     
    Natural Death                                      7            5            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           34           28                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
   Mesentery                                          (8)          (1)          (5)          (5)                                    
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (20%)                                            
      Schwannoma Malignant, Metastatic, Uterus         1 (13%)                                                                      
   Oral Mucosa                                        (1)                                    (1)                                    
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (2%)                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                                       3 (6%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (44)         (41)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          22 (44%)     20 (40%)     14 (28%)     15 (30%)                               
      Pars Distalis, Adenoma, Multiple                                                        1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
      C-Cell, Adenoma                                  3 (6%)       3 (6%)       1 (2%)       3 (6%)                                
      C-Cell, Carcinoma                                2 (4%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Abdominal, Paraganglioma                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (50)                                   
      Adenoma                                          4 (8%)       1 (2%)       1 (2%)       2 (4%)                                
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)                                             
      Bilateral, Adenoma                                                                      1 (2%)                                
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Benign                                                1 (2%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
      Thecoma Malignant                                                          1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
      Polyp Stromal                                    6 (12%)      6 (12%)      3 (6%)       4 (8%)                                
      Sarcoma Stromal                                                            1 (2%)       1 (2%)                                
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
   Vagina                                             (2)                       (1)                                                 
      Schwannoma Malignant, Metastatic, Uterus         1 (50%)                                                                      
____________________________________________________________________________________________________________________________________

                                                             Page   3                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (35)         (27)         (26)         (28)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (4%)       1 (4%)                                             
      Mediastinal, Carcinoma, Metastatic,                                                                                           
          Intestine Small, Jejunum                                               1 (4%)                                             
      Pancreatic, Carcinoma, Metastatic, Intestine                                                                                  
          Small, Jejunum                                                         1 (4%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (50)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (48)         (44)         (48)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)       2 (4%)       2 (4%)                                             
      Carcinoma, Multiple                                           1 (2%)                                                          
      Fibroadenoma                                    16 (32%)     17 (34%)     18 (36%)     11 (22%)                               
      Fibroadenoma, Multiple                           9 (18%)      3 (6%)       1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Keratoacanthoma                                                                         1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Vertebra, Fibrosarcoma                                                     1 (2%)                                             
   Skeletal Muscle                                                              (2)          (1)                                    
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Ureter                                                                                    (1)                                    
      Carcinoma                                                                               1 (100%)                              
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            15 (30%)     15 (30%)     15 (30%)     18 (36%)                               
      Lymphoma Malignant                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          43          42          43                                       
     Total Primary Neoplasms                           93          77          69          69                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          37          27          30                                       
     Total Benign Neoplasms                            70          56          42          45                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          18          23          24                                       
     Total Malignant Neoplasms                         23          21          27          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           2           1                                       
     Total Metastatic Neoplasm                          3           1           9           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           28           24           11                                     
    Natural Death                                     10            6            5            8                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                      2                                     
    Terminal Sacrifice                                11           16           21           29                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
   Intestine Small, Jejunum                           (49)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (49)         (50)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Mesentery                                          (15)         (12)         (15)         (11)                                   
      Lipoma                                                        1 (8%)                                                          
      Fat, Osteosarcoma, Metastatic, Spleen                                                   1 (9%)                                
      Fat, Sarcoma                                     1 (7%)                                                                       
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (48)                                   
      Acinus, Adenoma                                  2 (4%)                    1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Tongue                                             (1)                       (1)          (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Pheochromocytoma Complex                         1 (2%)       1 (2%)                                                          
      Pheochromocytoma Benign                          7 (14%)     17 (34%)     17 (34%)     12 (24%)                               
      Bilateral, Pheochromocytoma Benign               7 (14%)      4 (8%)       3 (6%)      11 (22%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (48)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                                                               1 (2%)                                
   Parathyroid Gland                                  (47)         (45)         (47)         (46)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Pars Distalis, Adenoma                          18 (36%)     16 (32%)     13 (27%)     13 (26%)                               
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
      Pars Distalis, Carcinoma                                                                1 (2%)                                
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  5 (10%)      8 (16%)      7 (14%)      6 (12%)                               
      C-Cell, Carcinoma                                             2 (4%)       2 (4%)       2 (4%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          4 (8%)                    3 (6%)       1 (2%)                                
      Carcinoma                                        1 (2%)       7 (14%)      1 (2%)                                             
      Bilateral, Adenoma                                            1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Carcinoma                                                                  1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   

                                                             Page   8                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     35 (70%)     42 (84%)     42 (84%)                               
      Interstitial Cell, Adenoma                       8 (16%)     12 (24%)      3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
   Lymph Node                                         (34)         (34)         (35)         (41)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                       1 (2%)                                
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Liver                                                      1 (3%)                                             
      Mediastinal, Osteosarcoma, Metastatic, Spleen                                           1 (2%)                                
      Mediastinal, Sarcoma, Metastatic, Mesentery      1 (3%)                                                                       
      Renal, Pheochromocytoma Malignant,                                                                                            
          Metastatic, Adrenal Medulla                                            1 (3%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Osteosarcoma                                                                            1 (2%)                                
   Thymus                                             (49)         (46)         (49)         (47)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (50)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
      Fibroadenoma                                     5 (10%)      5 (11%)      4 (8%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Keratoacanthoma                                               2 (4%)       1 (2%)       3 (6%)                                
      Squamous Cell Papilloma                          2 (4%)       1 (2%)                    3 (6%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                 2 (4%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)       1 (2%)                                                          

                                                             Page   9                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Vertebra, Chordoma                                                         1 (2%)                                             
      Vertebra, Hemangiosarcoma                        1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                       (1)                                    
      Osteosarcoma, Metastatic, Spleen                                                        1 (100%)                              
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Chordoma, Metastatic, Bone                                                 1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Mediastinum, Hemangiosarcoma                                  1 (2%)                                                          
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                                                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)       3 (6%)       1 (2%)                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)          (2)                                    
      Adenoma                                                                                 1 (50%)                               
      Carcinoma                                                                  1 (100%)     1 (50%)                               
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                                                             Page  10                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
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         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Liver                                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
      Renal Tubule, Carcinoma                                                                 2 (4%)                                
   Urinary Bladder                                    (48)         (50)         (50)         (49)                                   
      Transitional Epithelium, Papilloma               1 (2%)                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            25 (50%)     26 (52%)     26 (52%)     23 (46%)                               
      Mesothelioma Malignant                           1 (2%)                    2 (4%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:03:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          48                                       
     Total Primary Neoplasms                          135         155         145         141                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          50          48          48                                       
     Total Benign Neoplasms                           100         110         101         103                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          37          36          32                                       
     Total Malignant Neoplasms                         35          45          44          38                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           4           4                                       
     Total Metastatic Neoplasm                          1           5          13          10                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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