TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
Core Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 003 200 PPM
Include 004 200 PPM
Include 005 400 PPM
Include 006 400 PPM
Include 007 600 PPM
Include 008 600 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 50 50 50
Early Deaths
Moribund Sacrifice 15 12 12 17
Natural Death 7 5 4 5
Survivors
Terminal Sacrifice 28 33 34 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Rectum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (50) (50) (50)
Mesentery (8) (1) (5) (5)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (20%)
Schwannoma Malignant, Metastatic, Uterus 1 (13%)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (49) (50) (50)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Salivary Glands (50) (49) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Heart (50) (50) (50) (50)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 3 (6%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (49) (50) (50)
Adenoma 1 (2%)
Parathyroid Gland (46) (44) (41) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 22 (44%) 20 (40%) 14 (28%) 15 (30%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (6%) 3 (6%) 1 (2%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abdominal, Paraganglioma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (48) (50)
Adenoma 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Thecoma Malignant 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 6 (12%) 6 (12%) 3 (6%) 4 (8%)
Sarcoma Stromal 1 (2%) 1 (2%)
Schwannoma Malignant, Metastatic, Uterus 1 (2%)
Vagina (2) (1)
Schwannoma Malignant, Metastatic, Uterus 1 (50%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (35) (27) (26) (28)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (4%) 1 (4%)
Mediastinal, Carcinoma, Metastatic,
Intestine Small, Jejunum 1 (4%)
Pancreatic, Carcinoma, Metastatic, Intestine
Small, Jejunum 1 (4%)
Lymph Node, Mandibular (50) (49) (50) (50)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Thymus (48) (44) (48) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 2 (4%) 2 (4%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 16 (32%) 17 (34%) 18 (36%) 11 (22%)
Fibroadenoma, Multiple 9 (18%) 3 (6%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Vertebra, Fibrosarcoma 1 (2%)
Skeletal Muscle (2) (1)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Nose (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Ureter (1)
Carcinoma 1 (100%)
Urinary Bladder (50) (50) (49) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 15 (30%) 15 (30%) 15 (30%) 18 (36%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 43 42 43
Total Primary Neoplasms 93 77 69 69
Total Animals with Benign Neoplasms 37 37 27 30
Total Benign Neoplasms 70 56 42 45
Total Animals with Malignant Neoplasms 20 18 23 24
Total Malignant Neoplasms 23 21 27 24
Total Animals with Metastatic Neoplasms 1 1 2 1
Total Metastatic Neoplasm 3 1 9 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 50 50 50
Early Deaths
Moribund Sacrifice 28 28 24 11
Natural Death 10 6 5 8
Survivors
Natural Death 1 2
Terminal Sacrifice 11 16 21 29
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (49)
Intestine Large, Rectum (50) (50) (50) (49)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (49)
Intestine Small, Jejunum (49) (50) (50) (50)
Intestine Small, Ileum (49) (50) (50) (49)
Liver (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Mesentery (15) (12) (15) (11)
Lipoma 1 (8%)
Fat, Osteosarcoma, Metastatic, Spleen 1 (9%)
Fat, Sarcoma 1 (7%)
Oral Mucosa (1) (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (48)
Acinus, Adenoma 2 (4%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Tongue (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Heart (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 7 (14%) 17 (34%) 17 (34%) 12 (24%)
Bilateral, Pheochromocytoma Benign 7 (14%) 4 (8%) 3 (6%) 11 (22%)
Islets, Pancreatic (50) (50) (50) (48)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (47) (45) (47) (46)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (49) (50)
Pars Distalis, Adenoma 18 (36%) 16 (32%) 13 (27%) 13 (26%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 5 (10%) 8 (16%) 7 (14%) 6 (12%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Preputial Gland (50) (50) (50) (50)
Adenoma 4 (8%) 3 (6%) 1 (2%)
Carcinoma 1 (2%) 7 (14%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Prostate (50) (50) (50) (49)
Carcinoma 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Page 8
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 35 (70%) 42 (84%) 42 (84%)
Interstitial Cell, Adenoma 8 (16%) 12 (24%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Lymph Node (34) (34) (35) (41)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Liver 1 (3%)
Mediastinal, Osteosarcoma, Metastatic, Spleen 1 (2%)
Mediastinal, Sarcoma, Metastatic, Mesentery 1 (3%)
Renal, Pheochromocytoma Malignant,
Metastatic, Adrenal Medulla 1 (3%)
Lymph Node, Mandibular (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Spleen (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Osteosarcoma 1 (2%)
Thymus (49) (46) (49) (47)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (47) (50) (49)
Carcinoma 1 (2%)
Fibroadenoma 5 (10%) 5 (11%) 4 (8%) 2 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Keratoacanthoma 2 (4%) 1 (2%) 3 (6%)
Squamous Cell Papilloma 2 (4%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) 1 (2%)
Page 9
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Vertebra, Chordoma 1 (2%)
Vertebra, Hemangiosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Osteosarcoma, Metastatic, Spleen 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Hemangiosarcoma 1 (2%)
Mediastinum, Squamous Cell Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (48) (50) (50) (49)
Transitional Epithelium, Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 25 (50%) 26 (52%) 26 (52%) 23 (46%)
Mesothelioma Malignant 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:03:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 48
Total Primary Neoplasms 135 155 145 141
Total Animals with Benign Neoplasms 48 50 48 48
Total Benign Neoplasms 100 110 101 103
Total Animals with Malignant Neoplasms 32 37 36 32
Total Malignant Neoplasms 35 45 44 38
Total Animals with Metastatic Neoplasms 1 2 4 4
Total Metastatic Neoplasm 1 5 13 10
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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