National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6143

TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 10:54:39

                                                     Control vs Stop Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 009    1000 PPM
                               Include 010    1000 PPM






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           17                                                               
    Natural Death                                      7            5                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           28                                                               

  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)                                                             
   Intestine Small, Duodenum                          (50)         (50)                                                             
   Intestine Small, Jejunum                           (50)         (50)                                                             
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)                                                             
   Liver                                              (50)         (50)                                                             
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Mesentery                                          (8)          (6)                                                              
      Schwannoma Malignant, Metastatic, Uterus         1 (13%)                                                                      
      Fat, Sarcoma Stromal, Metastatic, Uterus                      1 (17%)                                                         
   Oral Mucosa                                        (1)          (2)                                                              
      Pharyngeal, Squamous Cell Carcinoma                           1 (50%)                                                         
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)                                                             
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Acinus, Adenoma                                               1 (2%)                                                          
   Salivary Glands                                    (50)         (50)                                                             
   Stomach, Forestomach                               (50)         (50)                                                             
   Stomach, Glandular                                 (50)         (50)                                                             
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
   Adrenal Medulla                                    (50)         (50)                                                             
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                          1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (45)                                                             
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Adenoma                          22 (44%)     18 (36%)                                                         
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)                                                             
      Bilateral, C-Cell, Adenoma                                    2 (4%)                                                          
      C-Cell, Adenoma                                  3 (6%)       5 (10%)                                                         
      C-Cell, Carcinoma                                2 (4%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)                                                             
      Adenoma                                          4 (8%)       5 (10%)                                                         
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Ovary                                              (50)         (50)                                                             
   Uterus                                             (50)         (50)                                                             
      Polyp Stromal                                    6 (12%)      6 (12%)                                                         
      Sarcoma Stromal                                               1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
   Vagina                                             (2)                                                                           
      Schwannoma Malignant, Metastatic, Uterus         1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)                                                             
   Lymph Node                                         (35)         (30)                                                             
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (3%)                                                          
   Lymph Node, Mandibular                             (50)         (50)                                                             
   Lymph Node, Mesenteric                             (50)         (50)                                                             

                                                             Page   3                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (48)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)                                                             
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                    16 (32%)     10 (20%)                                                         
      Fibroadenoma, Multiple                           9 (18%)      5 (10%)                                                         
   Skin                                               (50)         (50)                                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Cranial Nerve, Squamous Cell Carcinoma,                                                                                       
          Metastatic, Oral Mucosa                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Clitoral Gland                         1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
   Urinary Bladder                                    (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            15 (30%)     11 (22%)                                                         
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          42                                                               
     Total Primary Neoplasms                           93          71                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          35                                                               
     Total Benign Neoplasms                            70          55                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          16                                                               
     Total Malignant Neoplasms                         23          16                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                                                               
     Total Metastatic Neoplasm                          3           8                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           17                                                               
    Natural Death                                     10            6                                                               
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                11           27                                                               

  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (49)                                                             
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (49)                                                             
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (50)                                                             
   Intestine Small, Jejunum                           (49)         (50)                                                             
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (49)         (49)                                                             
      Carcinoma                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                   1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
   Mesentery                                          (15)         (15)                                                             
      Fat, Sarcoma                                     1 (7%)                                                                       
   Oral Mucosa                                        (1)          (2)                                                              
      Squamous Cell Papilloma                                       1 (50%)                                                         
      Gingival, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Nose                                          1 (50%)                                                         
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)                                                             
      Acinus, Adenoma                                  2 (4%)                                                                       
   Salivary Glands                                    (50)         (50)                                                             
   Stomach, Glandular                                 (50)         (50)                                                             
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)                                                             
      Pheochromocytoma Malignant                       1 (2%)       3 (6%)                                                          
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          7 (14%)     12 (24%)                                                         
      Bilateral, Pheochromocytoma Benign               7 (14%)      4 (8%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
   Parathyroid Gland                                  (47)         (47)                                                             
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Adenoma                          18 (36%)     16 (32%)                                                         
   Thyroid Gland                                      (50)         (50)                                                             
      C-Cell, Adenoma                                  5 (10%)      4 (8%)                                                          
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
   Preputial Gland                                    (50)         (49)                                                             
      Adenoma                                          4 (8%)       4 (8%)                                                          
      Carcinoma                                        1 (2%)       2 (4%)                                                          
   Prostate                                           (50)         (50)                                                             
   Seminal Vesicle                                    (50)         (50)                                                             
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     38 (76%)                                                         
      Interstitial Cell, Adenoma                       8 (16%)      7 (14%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
   Lymph Node                                         (34)         (28)                                                             
      Mediastinal, Sarcoma, Metastatic, Mesentery      1 (3%)                                                                       
   Lymph Node, Mandibular                             (50)         (50)                                                             
   Lymph Node, Mesenteric                             (50)         (50)                                                             
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (49)         (48)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)                                                             
      Fibroadenoma                                     5 (10%)      2 (4%)                                                          
   Skin                                               (50)         (50)                                                             
      Basal Cell Adenoma                               1 (2%)       2 (4%)                                                          
      Keratoacanthoma                                               6 (12%)                                                         
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Papilloma                          2 (4%)                                                                       
      Trichoepithelioma                                             2 (4%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Vertebra, Hemangiosarcoma                        1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Astrocytoma Malignant                                         1 (2%)                                                          
      Oligodendroglioma Malignant                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
      Squamous Cell Carcinoma                          1 (2%)       5 (10%)                                                         

                                                             Page   9                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenoma                            1 (2%)       2 (4%)                                                          
      Renal Tubule, Oncocytoma Benign                               1 (2%)                                                          
   Urinary Bladder                                    (48)         (49)                                                             
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            25 (50%)     15 (30%)                                                         
      Mesothelioma Malignant                           1 (2%)       9 (18%)                                                         
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 89002-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:54:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49                                                               
     Total Primary Neoplasms                          135         152                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47                                                               
     Total Benign Neoplasms                           100         110                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          29                                                               
     Total Malignant Neoplasms                         35          42                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3                                                               
     Total Metastatic Neoplasm                          1           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.