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TDMS Study 89002-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Pheochromocytoma Benign
Clitoral/Preputial Gland               Carcinoma
                                       Carcinoma or Adenoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
                                       Carcinoma or Adenoma
Testes                                 Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                       Papilloma Squamous or Papilloma
                                       Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
                                       Carcinoma or Adenoma
All Organs                             Benign Tumors
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)        -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  21/50 (42%)  20/50 (40%)  23/50 (46%) |0/50 (0%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     35.0%        53.7%        50.0%        52.3%       |0.0%         7.0%         2.3%         2.5%         |
|TERMINAL (d)       |     5/12 (42%)   11/16 (69%)  13/21 (62%)  19/31 (61%) |0/28 (0%)    3/33 (9%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     579          507          583          702         |---          738 (T)      690          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.105N     P=0.214      P=0.507      P=0.252N    |P=0.496      P=0.151      P=0.511      P=0.500      |
|POLY 3             |     P=0.087      P=0.064      P=0.120      P=0.078     |P=0.508      P=0.126      P=0.510      P=0.498      |
|POLY 1.5           |     P=0.067      P=0.080      P=0.131      P=0.061     |P=0.505      P=0.121      P=0.505      P=0.499      |
|POLY 6             |     P=0.128      P=0.049 *    P=0.107      P=0.108     |P=0.513      P=0.134      P=0.517      P=0.495      |
|LOGISTIC REGRESSION|     P=0.252      P=0.070      P=0.154      P=0.220     |P=0.488      P=0.151      P=0.501      P=0.500      |
|COCH-ARM / FISHERS |     P=0.053      P=0.104      P=0.146      P=0.048 *   |P=0.500      P=0.121      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         2.8%         7.9%         2.3%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/16 (6%)    3/21 (14%)   1/31 (3%)   |0/28 (0%)    1/33 (3%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     736 (T)      736 (T)      736 (T)      736 (T)     |---          738 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.374N     P=0.698N     P=0.520      P=0.537N    |P=0.498N     P=0.533      (e)          (e)          |
|POLY 3             |     P=0.522      P=0.754      P=0.311      P=0.726N    |P=0.502N     P=0.508      (e)          (e)          |
|POLY 1.5           |     P=0.477      P=0.756      P=0.309      P=0.742N    |P=0.501N     P=0.503      (e)          (e)          |
|POLY 6             |     P=0.588      P=0.753      P=0.318      P=0.699N    |P=0.506N     P=0.517      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.374N     P=0.698N     P=0.520      P=0.537N    |(e)          P=0.533      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.426      P=0.753N     P=0.309      P=0.753N    |P=0.500N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  22/50 (44%)  21/50 (42%)  24/50 (48%) |0/50 (0%)    4/50 (8%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     39.9%        55.1%        52.5%        54.5%       |0.0%         9.3%         2.3%         2.5%         |
|TERMINAL (d)       |     6/12 (50%)   11/16 (69%)  14/21 (67%)  20/31 (65%) |0/28 (0%)    4/33 (12%)   0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     579          450          583          702         |---          738 (T)      690          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054N     P=0.294      P=0.522N     P=0.132N    |P=0.573      P=0.085      P=0.511      P=0.500      |
|POLY 3             |     P=0.125      P=0.115      P=0.173      P=0.122     |P=0.571N     P=0.065      P=0.510      P=0.498      |
|POLY 1.5           |     P=0.099      P=0.131      P=0.187      P=0.097     |P=0.572N     P=0.062      P=0.505      P=0.499      |
|POLY 6             |     P=0.177      P=0.098      P=0.155      P=0.167     |P=0.572N     P=0.071      P=0.517      P=0.495      |
|LOGISTIC REGRESSION|     P=0.321      P=0.110      P=0.217      P=0.339     |P=0.562      P=0.085      P=0.501      P=0.500      |
|COCH-ARM / FISHERS |     P=0.079      P=0.151      P=0.204      P=0.076     |P=0.574N     P=0.059      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |4/50 (8%)    1/50 (2%)    1/48 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     10.5%        2.7%         7.7%         2.3%        |9.7%         2.3%         2.4%         7.1%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    2/21 (10%)   0/31 (0%)   |3/28 (11%)   0/33 (0%)    1/34 (3%)    1/28 (4%)    |
|FIRST INCIDENCE    |     647          450          521          544         |645          701          738 (T)      417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.081N     P=0.177N     P=0.372N     P=0.085N    |P=0.384N     P=0.143N     P=0.136N     P=0.507N     |
|POLY 3             |     P=0.136N     P=0.186N     P=0.490N     P=0.136N    |P=0.385N     P=0.167N     P=0.178N     P=0.493N     |
|POLY 1.5           |     P=0.156N     P=0.183N     P=0.494N     P=0.155N    |P=0.383N     P=0.175N     P=0.184N     P=0.494N     |
|POLY 6             |     P=0.109N     P=0.189N     P=0.483N     P=0.113N    |P=0.391N     P=0.155N     P=0.169N     P=0.497N     |
|LOGISTIC REGRESSION|     P=0.204N     P=0.176N     P=0.493N     P=0.193N    |P=0.387N     P=0.166N     P=0.169N     P=0.501N     |
|COCH-ARM / FISHERS |     P=0.180N     P=0.181N     P=0.500N     P=0.181N    |P=0.386N     P=0.181N     P=0.194N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    7/50 (14%)   1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    2/48 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         18.8%        2.6%         0.0%        |4.9%         2.3%         4.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    3/16 (19%)   0/21 (0%)    0/31 (0%)   |1/28 (4%)    0/33 (0%)    1/34 (3%)    0/28 (0%)    |
|FIRST INCIDENCE    |     396          544          360          ---         |715          700          670          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.038N*    P=0.054      P=0.758      P=0.504N    |P=0.211N     P=0.434N     P=0.633N     P=0.243N     |
|POLY 3             |     P=0.074N     P=0.025 *    P=0.757N     P=0.474N    |P=0.223N     P=0.486N     P=0.691N     P=0.239N     |
|POLY 1.5           |     P=0.088N     P=0.027 *    P=0.758N     P=0.487N    |P=0.217N     P=0.495N     P=0.689      P=0.238N     |
|POLY 6             |     P=0.054N     P=0.024 *    P=0.753N     P=0.455N    |P=0.236N     P=0.470N     P=0.677N     P=0.243N     |
|LOGISTIC REGRESSION|     P=0.137N     P=0.033 *    (e)          P=0.435N    |P=0.212N     P=0.480N     P=0.690N     P=0.245N     |
|COCH-ARM / FISHERS |     P=0.111N     P=0.030 *    P=0.753N     P=0.500N    |P=0.213N     P=0.500N     P=0.676      P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   4/50 (8%)    1/50 (2%)   |6/50 (12%)   2/50 (4%)    3/48 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     12.8%        21.0%        10.1%        2.3%        |14.4%        4.6%         7.2%         7.1%         |
|TERMINAL (d)       |     1/12 (8%)    3/16 (19%)   2/21 (10%)   0/31 (0%)   |4/28 (14%)   0/33 (0%)    2/34 (6%)    1/28 (4%)    |
|FIRST INCIDENCE    |     396          450          360          544         |645          700          670          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009N**   P=0.346      P=0.389N     P=0.048N*   |P=0.199N     P=0.095N     P=0.174N     P=0.255N     |
|POLY 3             |     P=0.026N*    P=0.254      P=0.488N     P=0.074N    |P=0.196N     P=0.120N     P=0.239N     P=0.234N     |
|POLY 1.5           |     P=0.034N*    P=0.263      P=0.492N     P=0.086N    |P=0.195N     P=0.128N     P=0.250N     P=0.236N     |
|POLY 6             |     P=0.016N*    P=0.248      P=0.481N     P=0.059N    |P=0.204N     P=0.107N     P=0.223N     P=0.238N     |
|LOGISTIC REGRESSION|     P=0.067N     P=0.279      P=0.518N     P=0.137N    |P=0.198N     P=0.118N     P=0.229N     P=0.242N     |
|COCH-ARM / FISHERS |     P=0.049N*    P=0.277      P=0.500N     P=0.102N    |P=0.199N     P=0.134N     P=0.264N     P=0.243N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/48 (4%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.8%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    2/30 (7%)   |1/28 (4%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          736 (T)     |738 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.125      (e)          (e)          P=0.455     |P=0.176N     P=0.467N     P=0.461N     P=0.500N     |
|POLY 3             |     P=0.058      (e)          (e)          P=0.262     |P=0.192N     P=0.496N     P=0.491N     P=0.502N     |
|POLY 1.5           |     P=0.055      (e)          (e)          P=0.246     |P=0.188N     P=0.501N     P=0.495N     P=0.501N     |
|POLY 6             |     P=0.064      (e)          (e)          P=0.288     |P=0.200N     P=0.487N     P=0.485N     P=0.505N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.455     |P=0.176N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.053      (e)          (e)          P=0.237     |P=0.185N     P=0.505N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    2/31 (7%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          736 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129      (e)          (e)          P=0.463     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.062      (e)          (e)          P=0.272     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.058      (e)          (e)          P=0.256     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.069      (e)          (e)          P=0.299     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.463     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.056      (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         2.8%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    2/31 (7%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     695          736 (T)      ---          736 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.526N     P=0.729N     P=0.484N     P=0.713N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.446      P=0.753      P=0.497N     P=0.551     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.429      P=0.756      P=0.498N     P=0.528     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.473      P=0.751      P=0.493N     P=0.586     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.553      P=0.760      P=0.494N     P=0.638     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.411      P=0.753N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.5%         0.0%         0.0%        |4.8%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/16 (13%)   0/21 (0%)    0/31 (0%)   |1/28 (4%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      ---          ---         |645          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.201N     P=0.302      (e)          (e)         |P=0.055N     P=0.216N     P=0.216N     P=0.255N     |
|POLY 3             |     P=0.355N     P=0.228      (e)          (e)         |P=0.057N     P=0.230N     P=0.229N     P=0.241N     |
|POLY 1.5           |     P=0.364N     P=0.232      (e)          (e)         |P=0.056N     P=0.235N     P=0.233N     P=0.238N     |
|POLY 6             |     P=0.338N     P=0.226      (e)          (e)         |P=0.060N     P=0.222N     P=0.223N     P=0.245N     |
|LOGISTIC REGRESSION|     (e)          P=0.302      (e)          (e)         |P=0.056N     P=0.236N     P=0.235N     P=0.238N     |
|COCH-ARM / FISHERS |     P=0.375N     P=0.247      (e)          (e)         |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.5%         2.6%         0.0%        |7.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/16 (13%)   0/21 (0%)    0/31 (0%)   |2/28 (7%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      688          ---         |645          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.308N     P=0.302      P=0.515      (e)         |P=0.017N*    P=0.101N     P=0.099N     P=0.131N     |
|POLY 3             |     P=0.451N     P=0.228      P=0.505      (e)         |P=0.018N*    P=0.113N     P=0.112N     P=0.121N     |
|POLY 1.5           |     P=0.474N     P=0.232      P=0.503      (e)         |P=0.018N*    P=0.117N     P=0.115N     P=0.120N     |
|POLY 6             |     P=0.415N     P=0.226      P=0.511      (e)         |P=0.019N*    P=0.106N     P=0.107N     P=0.125N     |
|LOGISTIC REGRESSION|     P=0.400N     P=0.302      P=0.504      (e)         |P=0.018N*    P=0.115N     P=0.114N     P=0.122N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.247      P=0.500      (e)         |P=0.019N*    P=0.121N     P=0.121N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         0.0%         0.0%        |2.4%         6.9%         4.7%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    0/31 (0%)   |1/28 (4%)    2/33 (6%)    2/34 (6%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      ---          ---         |738 (T)      430          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.360N     P=0.557      (e)          (e)         |P=0.281N     P=0.347      P=0.568      P=0.500N     |
|POLY 3             |     P=0.498N     P=0.493      (e)          (e)         |P=0.295N     P=0.326      P=0.516      P=0.502N     |
|POLY 1.5           |     P=0.500N     P=0.496      (e)          (e)         |P=0.291N     P=0.315      P=0.508      P=0.501N     |
|POLY 6             |     P=0.492N     P=0.491      (e)          (e)         |P=0.303N     P=0.344      P=0.526      P=0.505N     |
|LOGISTIC REGRESSION|     (e)          P=0.557      (e)          (e)         |P=0.289N     P=0.304      P=0.568      (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.289N     P=0.309      P=0.500      P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         0.0%         0.0%        |2.4%         6.9%         7.0%         2.5%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    0/31 (0%)   |1/28 (4%)    2/33 (6%)    3/34 (9%)    1/28 (4%)    |
|FIRST INCIDENCE    |     ---          736 (T)      ---          ---         |738 (T)      430          738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.360N     P=0.557      (e)          (e)         |P=0.562N     P=0.347      P=0.376      P=0.762      |
|POLY 3             |     P=0.498N     P=0.493      (e)          (e)         |P=0.561      P=0.326      P=0.321      P=0.759      |
|POLY 1.5           |     P=0.500N     P=0.496      (e)          (e)         |P=0.564      P=0.315      P=0.314      P=0.760      |
|POLY 6             |     P=0.492N     P=0.491      (e)          (e)         |P=0.554      P=0.344      P=0.332      P=0.756      |
|LOGISTIC REGRESSION|     (e)          P=0.557      (e)          (e)         |P=0.564      P=0.304      P=0.376      P=0.762      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.564N     P=0.309      P=0.309      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   4/50 (8%)    2/50 (4%)   |25/50 (50%)  20/50 (40%)  19/50 (38%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     13.0%        13.8%        10.4%        4.6%        |56.7%        45.7%        41.9%        28.6%        |
|TERMINAL (d)       |     1/12 (8%)    3/16 (19%)   3/21 (14%)   2/31 (7%)   |16/28 (57%)  16/33 (49%)  14/34 (41%)  7/28 (25%)   |
|FIRST INCIDENCE    |     619          698          698          736 (T)     |507          620          417          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.015N*    P=0.544N     P=0.329N     P=0.052N    |P=0.007N**   P=0.087N     P=0.063N     P=0.013N*    |
|POLY 3             |     P=0.099N     P=0.598      P=0.501N     P=0.166N    |P=0.005N**   P=0.202N     P=0.111N     P=0.005N**   |
|POLY 1.5           |     P=0.120N     P=0.612      P=0.500N     P=0.188N    |P=0.004N**   P=0.215N     P=0.128N     P=0.005N**   |
|POLY 6             |     P=0.074N     P=0.582      P=0.500N     P=0.138N    |P=0.006N**   P=0.178N     P=0.095N     P=0.007N**   |
|LOGISTIC REGRESSION|     P=0.060N     P=0.608      P=0.474N     P=0.159N    |P=0.005N**   P=0.160N     P=0.134N     P=0.006N**   |
|COCH-ARM / FISHERS |     P=0.147N     P=0.630N     P=0.500N     P=0.218N    |P=0.006N**   P=0.211N     P=0.157N     P=0.006N**   |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   4/50 (8%)    2/50 (4%)   |25/50 (50%)  20/50 (40%)  19/50 (38%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     13.0%        13.8%        10.4%        4.6%        |56.7%        45.7%        41.9%        31.0%        |
|TERMINAL (d)       |     1/12 (8%)    3/16 (19%)   3/21 (14%)   2/31 (7%)   |16/28 (57%)  16/33 (49%)  14/34 (41%)  8/28 (29%)   |
|FIRST INCIDENCE    |     619          698          698          736 (T)     |507          620          417          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.015N*    P=0.544N     P=0.329N     P=0.052N    |P=0.012N*    P=0.087N     P=0.063N     P=0.022N*    |
|POLY 3             |     P=0.099N     P=0.598      P=0.501N     P=0.166N    |P=0.009N**   P=0.202N     P=0.111N     P=0.011N*    |
|POLY 1.5           |     P=0.120N     P=0.612      P=0.500N     P=0.188N    |P=0.008N**   P=0.215N     P=0.128N     P=0.010N*    |
|POLY 6             |     P=0.074N     P=0.582      P=0.500N     P=0.138N    |P=0.011N*    P=0.178N     P=0.095N     P=0.013N*    |
|LOGISTIC REGRESSION|     P=0.060N     P=0.608      P=0.474N     P=0.159N    |P=0.009N**   P=0.160N     P=0.134N     P=0.011N*    |
|COCH-ARM / FISHERS |     P=0.147N     P=0.630N     P=0.500N     P=0.218N    |P=0.010N*    P=0.211N     P=0.157N     P=0.011N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   4/50 (8%)    2/50 (4%)   |25/50 (50%)  22/50 (44%)  21/50 (42%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     13.0%        13.8%        10.4%        4.6%        |56.7%        49.4%        46.3%        31.0%        |
|TERMINAL (d)       |     1/12 (8%)    3/16 (19%)   3/21 (14%)   2/31 (7%)   |16/28 (57%)  17/33 (52%)  16/34 (47%)  8/28 (29%)   |
|FIRST INCIDENCE    |     619          698          698          736 (T)     |507          430          417          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.015N*    P=0.544N     P=0.329N     P=0.052N    |P=0.013N*    P=0.164N     P=0.115N     P=0.022N*    |
|POLY 3             |     P=0.099N     P=0.598      P=0.501N     P=0.166N    |P=0.010N*    P=0.314N     P=0.215N     P=0.011N*    |
|POLY 1.5           |     P=0.120N     P=0.612      P=0.500N     P=0.188N    |P=0.009N**   P=0.337N     P=0.238N     P=0.010N*    |
|POLY 6             |     P=0.074N     P=0.582      P=0.500N     P=0.138N    |P=0.013N*    P=0.276N     P=0.191N     P=0.013N*    |
|LOGISTIC REGRESSION|     P=0.060N     P=0.608      P=0.474N     P=0.159N    |P=0.009N**   P=0.303N     P=0.237N     P=0.011N*    |
|COCH-ARM / FISHERS |     P=0.147N     P=0.630N     P=0.500N     P=0.218N    |P=0.010N*    P=0.344N     P=0.274N     P=0.011N*    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         8.1%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     643          505          593          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.167N     P=0.301      P=0.744      P=0.473N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.171N     P=0.299      P=0.756N     P=0.471N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.188N     P=0.301      P=0.758N     P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.147N     P=0.300      P=0.752N     P=0.452N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.237N     P=0.314      P=0.758      P=0.520N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.209N     P=0.309      P=0.753N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         2.6%         0.0%        |4.9%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |2/28 (7%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     702          ---          640          ---         |738 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.083N     P=0.204N     P=0.423N     P=0.094N    |P=0.049N*    P=0.202N     P=0.196N     P=0.238N     |
|POLY 3             |     P=0.131N     P=0.245N     P=0.491N     P=0.205N    |P=0.057N     P=0.228N     P=0.227N     P=0.239N     |
|POLY 1.5           |     P=0.140N     P=0.242N     P=0.495N     P=0.220N    |P=0.056N     P=0.234N     P=0.232N     P=0.238N     |
|POLY 6             |     P=0.120N     P=0.247N     P=0.482N     P=0.185N    |P=0.060N     P=0.219N     P=0.220N     P=0.242N     |
|LOGISTIC REGRESSION|     P=0.127N     P=0.237N     P=0.490N     P=0.159N    |P=0.049N*    (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.149N     P=0.247N     P=0.500N     P=0.247N    |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         2.6%         2.3%        |4.9%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |2/28 (7%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     702          ---          640          605         |738 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.283N     P=0.204N     P=0.423N     P=0.305N    |P=0.049N*    P=0.202N     P=0.196N     P=0.238N     |
|POLY 3             |     P=0.381N     P=0.245N     P=0.491N     P=0.445N    |P=0.057N     P=0.228N     P=0.227N     P=0.239N     |
|POLY 1.5           |     P=0.396N     P=0.242N     P=0.495N     P=0.470N    |P=0.056N     P=0.234N     P=0.232N     P=0.238N     |
|POLY 6             |     P=0.358N     P=0.247N     P=0.482N     P=0.407N    |P=0.060N     P=0.219N     P=0.220N     P=0.242N     |
|LOGISTIC REGRESSION|     P=0.401N     P=0.237N     P=0.490N     P=0.490N    |P=0.049N*    (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.411N     P=0.247N     P=0.500N     P=0.500N    |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/48 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    1/21 (5%)    0/30 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     660          ---          736 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.068N     P=0.219N     P=0.380N     P=0.123N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.137N     P=0.246N     P=0.495N     P=0.215N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.145N     P=0.242N     P=0.497N     P=0.229N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.125N     P=0.249N     P=0.490N     P=0.195N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.115N     P=0.245N     P=0.477N     P=0.211N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.154N     P=0.247N     P=0.500N     P=0.258N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  16/50 (32%)  14/49 (29%)  13/50 (26%) |22/50 (44%)  20/50 (40%)  14/50 (28%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     41.5%        40.1%        34.4%        29.5%       |49.1%        44.9%        31.5%        38.1%        |
|TERMINAL (d)       |     4/12 (33%)   6/16 (38%)   5/21 (24%)   11/31 (36%) |11/28 (39%)  15/33 (46%)  10/34 (29%)  11/28 (39%)  |
|FIRST INCIDENCE    |     396          524          443          620         |507          522          544          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004N**   P=0.372N     P=0.142N     P=0.006N**  |P=0.078N     P=0.247N     P=0.039N*    P=0.197N     |
|POLY 3             |     P=0.108N     P=0.540N     P=0.327N     P=0.168N    |P=0.083N     P=0.425N     P=0.066N     P=0.201N     |
|POLY 1.5           |     P=0.124N     P=0.490N     P=0.309N     P=0.183N    |P=0.071N     P=0.433N     P=0.067N     P=0.174N     |
|POLY 6             |     P=0.086N     P=0.587N     P=0.343N     P=0.144N    |P=0.107N     P=0.409N     P=0.065N     P=0.256N     |
|LOGISTIC REGRESSION|     P=0.128N     P=0.406N     P=0.294N     P=0.215N    |P=0.063N     P=0.401N     P=0.065N     P=0.152N     |
|COCH-ARM / FISHERS |     P=0.141N     P=0.417N     P=0.283N     P=0.194N    |P=0.065N     P=0.420N     P=0.072N     P=0.151N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  16/50 (32%)  14/49 (29%)  14/50 (28%) |22/50 (44%)  20/50 (40%)  14/50 (28%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     41.5%        40.1%        34.4%        31.8%       |49.1%        44.9%        31.5%        38.1%        |
|TERMINAL (d)       |     4/12 (33%)   6/16 (38%)   5/21 (24%)   12/31 (39%) |11/28 (39%)  15/33 (46%)  10/34 (29%)  11/28 (39%)  |
|FIRST INCIDENCE    |     396          524          443          620         |507          522          544          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006N**   P=0.372N     P=0.142N     P=0.008N**  |P=0.078N     P=0.247N     P=0.039N*    P=0.197N     |
|POLY 3             |     P=0.156N     P=0.540N     P=0.327N     P=0.232N    |P=0.083N     P=0.425N     P=0.066N     P=0.201N     |
|POLY 1.5           |     P=0.175N     P=0.490N     P=0.309N     P=0.249N    |P=0.071N     P=0.433N     P=0.067N     P=0.174N     |
|POLY 6             |     P=0.129N     P=0.587N     P=0.343N     P=0.204N    |P=0.107N     P=0.409N     P=0.065N     P=0.256N     |
|LOGISTIC REGRESSION|     P=0.173N     P=0.406N     P=0.294N     P=0.277N    |P=0.063N     P=0.401N     P=0.065N     P=0.152N     |
|COCH-ARM / FISHERS |     P=0.193N     P=0.417N     P=0.283N     P=0.260N    |P=0.065N     P=0.420N     P=0.072N     P=0.151N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     8.0%         8.3%         5.2%         11.3%       |0.0%         0.0%         2.3%         2.5%         |
|TERMINAL (d)       |     2/12 (17%)   1/16 (6%)    2/21 (10%)   4/31 (13%)  |0/28 (0%)    0/33 (0%)    1/34 (3%)    1/28 (4%)    |
|FIRST INCIDENCE    |     684          722          736 (T)      518         |---          ---          738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.374N     P=0.574N     P=0.301N     P=0.522N    |P=0.163      (e)          P=0.539      P=0.500      |
|POLY 3             |     P=0.378      P=0.647      P=0.493N     P=0.448     |P=0.171      (e)          P=0.509      P=0.498      |
|POLY 1.5           |     P=0.342      P=0.653      P=0.496N     P=0.406     |P=0.172      (e)          P=0.505      P=0.499      |
|POLY 6             |     P=0.438      P=0.644      P=0.486N     P=0.511     |P=0.170      (e)          P=0.515      P=0.495      |
|LOGISTIC REGRESSION|     P=0.469      P=0.665N     P=0.428N     P=0.447     |(e)          (e)          P=0.539      P=0.500      |
|COCH-ARM / FISHERS |     P=0.304      P=0.661N     P=0.500N     P=0.357     |P=0.170      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         5.4%         5.2%         4.5%        |4.8%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    1/21 (5%)    1/31 (3%)   |1/28 (4%)    1/33 (3%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     603          505          666          614         |523          738 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.365N     P=0.680N     P=0.649N     P=0.551N    |P=0.055N     P=0.465N     P=0.216N     P=0.237N     |
|POLY 3             |     P=0.508N     P=0.683      P=0.692N     P=0.642N    |P=0.061N     P=0.491N     P=0.230N     P=0.242N     |
|POLY 1.5           |     P=0.535N     P=0.687      P=0.693N     P=0.666N    |P=0.060N     P=0.498N     P=0.234N     P=0.240N     |
|POLY 6             |     P=0.466N     P=0.678      P=0.689N     P=0.604N    |P=0.063N     P=0.479N     P=0.225N     P=0.247N     |
|LOGISTIC REGRESSION|     P=0.552      P=0.686N     P=0.694N     P=0.670     |P=0.060N     P=0.501N     P=0.248N     P=0.239N     |
|COCH-ARM / FISHERS |     P=0.564N     P=0.691N     P=0.691N     P=0.691N    |P=0.059N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    2/50 (4%)    4/50 (8%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     13.1%        8.0%         5.2%         9.1%        |7.2%         2.3%         2.3%         2.4%         |
|TERMINAL (d)       |     2/12 (17%)   1/16 (6%)    1/21 (5%)    3/31 (10%)  |2/28 (7%)    1/33 (3%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     603          505          666          614         |523          738 (T)      733          646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117N     P=0.315N     P=0.136N     P=0.159N    |P=0.174N     P=0.265N     P=0.254N     P=0.316N     |
|POLY 3             |     P=0.304N     P=0.366N     P=0.211N     P=0.413N    |P=0.181N     P=0.296N     P=0.294N     P=0.311N     |
|POLY 1.5           |     P=0.329N     P=0.362N     P=0.214N     P=0.453N    |P=0.179N     P=0.303N     P=0.300N     P=0.308N     |
|POLY 6             |     P=0.265N     P=0.369N     P=0.206N     P=0.357N    |P=0.187N     P=0.283N     P=0.286N     P=0.316N     |
|LOGISTIC REGRESSION|     P=0.336N     P=0.354N     P=0.206N     P=0.431N    |P=0.177N     P=0.305N     P=0.306N     P=0.305N     |
|COCH-ARM / FISHERS |     P=0.355N     P=0.357N     P=0.218N     P=0.500N    |P=0.177N     P=0.309N     P=0.309N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         0.0%         4.6%        |2.4%         0.0%         2.3%         2.4%         |
|TERMINAL (d)       |     2/12 (17%)   0/16 (0%)    0/21 (0%)    2/31 (7%)   |1/28 (4%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     736 (T)      ---          ---          736 (T)     |738 (T)      ---          733          646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311N     P=0.175N     P=0.124N     P=0.329N    |P=0.494      P=0.467N     P=0.713N     P=0.748      |
|POLY 3             |     P=0.586N     P=0.244N     P=0.232N     P=0.638N    |P=0.500      P=0.492N     P=0.751N     P=0.761      |
|POLY 1.5           |     P=0.589N     P=0.241N     P=0.234N     P=0.664N    |P=0.501      P=0.497N     P=0.755N     P=0.760N     |
|POLY 6             |     P=0.578N     P=0.245N     P=0.226N     P=0.596N    |P=0.498      P=0.483N     P=0.744N     P=0.759      |
|LOGISTIC REGRESSION|     P=0.311N     (e)          (e)          P=0.329N    |P=0.499      (e)          P=0.731N     P=0.762      |
|COCH-ARM / FISHERS |     P=0.589N     P=0.247N     P=0.247N     P=0.691N    |P=0.500      P=0.500N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     8.0%         2.7%         0.0%         4.6%        |2.4%         0.0%         2.3%         2.4%         |
|TERMINAL (d)       |     2/12 (17%)   0/16 (0%)    0/21 (0%)    2/31 (7%)   |1/28 (4%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     695          507          ---          736 (T)     |738 (T)      ---          733          646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.110N     P=0.259N     P=0.061N     P=0.158N    |P=0.494      P=0.467N     P=0.713N     P=0.748      |
|POLY 3             |     P=0.275N     P=0.311N     P=0.114N     P=0.433N    |P=0.500      P=0.492N     P=0.751N     P=0.761      |
|POLY 1.5           |     P=0.283N     P=0.309N     P=0.116N     P=0.464N    |P=0.501      P=0.497N     P=0.755N     P=0.760N     |
|POLY 6             |     P=0.262N     P=0.310N     P=0.110N     P=0.387N    |P=0.498      P=0.483N     P=0.744N     P=0.759      |
|LOGISTIC REGRESSION|     P=0.246N     P=0.311N     P=0.095N     P=0.279N    |P=0.499      (e)          P=0.731N     P=0.762      |
|COCH-ARM / FISHERS |     P=0.289N     P=0.309N     P=0.121N     P=0.500N    |P=0.500      P=0.500N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.5%         2.6%         6.8%        |0.0%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    1/21 (5%)    2/31 (7%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     ---          722          736 (T)      518         |---          ---          ---          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.266      P=0.290      P=0.612      P=0.249     |P=0.178      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.128      P=0.229      P=0.504      P=0.151     |P=0.193      (e)          (e)          P=0.498      |
|POLY 1.5           |     P=0.113      P=0.232      P=0.502      P=0.136     |P=0.189      (e)          (e)          P=0.499      |
|POLY 6             |     P=0.157      P=0.227      P=0.509      P=0.177     |P=0.199      (e)          (e)          P=0.495      |
|LOGISTIC REGRESSION|     P=0.130      P=0.246      P=0.612      P=0.109     |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.097      P=0.247      P=0.500      P=0.121     |P=0.185      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         2.8%         0.0%         6.9%        |0.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     2/12 (17%)   0/16 (0%)    0/21 (0%)    3/31 (10%)  |0/28 (0%)    0/33 (0%)    1/34 (3%)    0/28 (0%)    |
|FIRST INCIDENCE    |     736 (T)      723          ---          736 (T)     |---          ---          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.391N     P=0.413N     P=0.124N     P=0.456N    |P=0.502      (e)          P=0.539      (e)          |
|POLY 3             |     P=0.462      P=0.512N     P=0.232N     P=0.569     |P=0.498      (e)          P=0.509      (e)          |
|POLY 1.5           |     P=0.444      P=0.507N     P=0.234N     P=0.537     |P=0.499      (e)          P=0.505      (e)          |
|POLY 6             |     P=0.492      P=0.514N     P=0.226N     P=0.617     |P=0.494      (e)          P=0.515      (e)          |
|LOGISTIC REGRESSION|     P=0.465N     P=0.468N     (e)          P=0.456N    |(e)          (e)          P=0.539      (e)          |
|COCH-ARM / FISHERS |     P=0.426      P=0.500N     P=0.247N     P=0.500     |P=0.500      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         8.3%         2.6%         11.3%       |0.0%         0.0%         2.3%         2.5%         |
|TERMINAL (d)       |     2/12 (17%)   1/16 (6%)    1/21 (5%)    4/31 (13%)  |0/28 (0%)    0/33 (0%)    1/34 (3%)    1/28 (4%)    |
|FIRST INCIDENCE    |     736 (T)      722          736 (T)      518         |---          ---          738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.536N     P=0.608      P=0.306N     P=0.617     |P=0.163      (e)          P=0.539      P=0.500      |
|POLY 3             |     P=0.253      P=0.485      P=0.493N     P=0.289     |P=0.171      (e)          P=0.509      P=0.498      |
|POLY 1.5           |     P=0.228      P=0.491      P=0.496N     P=0.254     |P=0.172      (e)          P=0.505      P=0.499      |
|POLY 6             |     P=0.298      P=0.483      P=0.485N     P=0.344     |P=0.170      (e)          P=0.515      P=0.495      |
|LOGISTIC REGRESSION|     P=0.335      P=0.535      P=0.306N     P=0.291     |(e)          (e)          P=0.539      P=0.500      |
|COCH-ARM / FISHERS |     P=0.203      P=0.500      P=0.500N     P=0.218     |P=0.170      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         8.3%         2.6%         11.3%       |0.0%         0.0%         2.3%         2.5%         |
|TERMINAL (d)       |     2/12 (17%)   1/16 (6%)    1/21 (5%)    4/31 (13%)  |0/28 (0%)    0/33 (0%)    1/34 (3%)    1/28 (4%)    |
|FIRST INCIDENCE    |     736 (T)      722          736 (T)      518         |---          ---          738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.536N     P=0.608      P=0.306N     P=0.617     |P=0.163      (e)          P=0.539      P=0.500      |
|POLY 3             |     P=0.253      P=0.485      P=0.493N     P=0.289     |P=0.171      (e)          P=0.509      P=0.498      |
|POLY 1.5           |     P=0.228      P=0.491      P=0.496N     P=0.254     |P=0.172      (e)          P=0.505      P=0.499      |
|POLY 6             |     P=0.298      P=0.483      P=0.485N     P=0.344     |P=0.170      (e)          P=0.515      P=0.495      |
|LOGISTIC REGRESSION|     P=0.335      P=0.535      P=0.306N     P=0.291     |(e)          (e)          P=0.539      P=0.500      |
|COCH-ARM / FISHERS |     P=0.203      P=0.500      P=0.500N     P=0.218     |P=0.170      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  47/50 (94%)  45/50 (90%)  46/50 (92%) |                                                    |
|POLY-3 ADJUSTED (b)|     93.8%        97.5%        95.8%        95.6%       |                                                    |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|                                                    |
|FIRST INCIDENCE    |     561          410          521          518         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.465      P=0.181N     P<0.001N**  |                                                    |
|POLY 3             |     P=0.458      P=0.293      P=0.514      P=0.535     |                                                    |
|POLY 1.5           |     P=0.271      P=0.180      P=0.375      P=0.313     |                                                    |
|POLY 6             |     P=0.489N     P=0.589      P=0.784      P=0.782N    |                                                    |
|LOGISTIC REGRESSION|     P=0.468      P=0.031 *    P=0.242      P=0.621     |                                                    |
|COCH-ARM / FISHERS |     P=0.171      P=0.100      P=0.277      P=0.178     |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   7/50 (14%)   6/50 (12%)  |3/50 (6%)    3/50 (6%)    1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     12.9%        21.5%        17.7%        13.6%       |7.2%         7.0%         2.3%         9.7%         |
|TERMINAL (d)       |     1/12 (8%)    5/16 (31%)   3/21 (14%)   5/31 (16%)  |1/28 (4%)    3/33 (9%)    1/34 (3%)    2/28 (7%)    |
|FIRST INCIDENCE    |     535          450          593          544         |585          738 (T)      738 (T)      586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.165N     P=0.354      P=0.528      P=0.348N    |P=0.506      P=0.593N     P=0.263N     P=0.507      |
|POLY 3             |     P=0.494N     P=0.243      P=0.390      P=0.591     |P=0.503      P=0.652N     P=0.295N     P=0.494      |
|POLY 1.5           |     P=0.531      P=0.258      P=0.385      P=0.549     |P=0.503      P=0.660N     P=0.300N     P=0.498      |
|POLY 6             |     P=0.411N     P=0.226      P=0.403      P=0.606N    |P=0.501      P=0.637N     P=0.287N     P=0.485      |
|LOGISTIC REGRESSION|     P=0.537      P=0.259      P=0.383      P=0.520     |P=0.498      P=0.652N     P=0.303N     P=0.499      |
|COCH-ARM / FISHERS |     P=0.463      P=0.277      P=0.380      P=0.500     |P=0.500      P=0.661N     P=0.309N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.5%         5.2%         4.6%        |4.9%         2.3%         4.7%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    2/21 (10%)   2/31 (7%)   |2/28 (7%)    1/33 (3%)    2/34 (6%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          663          736 (T)      736 (T)     |738 (T)      738 (T)      738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.433      P=0.259      P=0.367      P=0.463     |P=0.197N     P=0.442N     P=0.624N     P=0.238N     |
|POLY 3             |     P=0.234      P=0.230      P=0.241      P=0.272     |P=0.218N     P=0.486N     P=0.678N     P=0.239N     |
|POLY 1.5           |     P=0.207      P=0.233      P=0.239      P=0.256     |P=0.212N     P=0.495N     P=0.685N     P=0.238N     |
|POLY 6             |     P=0.282      P=0.229      P=0.245      P=0.299     |P=0.229N     P=0.471N     P=0.667N     P=0.242N     |
|LOGISTIC REGRESSION|     P=0.304      P=0.229      P=0.367      P=0.463     |P=0.197N     P=0.442N     P=0.624N     (e)          |
|COCH-ARM / FISHERS |     P=0.177      P=0.247      P=0.247      P=0.247     |P=0.209N     P=0.500N     P=0.691N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   10/50 (20%)  9/50 (18%)   8/50 (16%)  |5/50 (10%)   4/50 (8%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     12.9%        26.7%        22.8%        18.1%       |12.0%        9.3%         7.0%         9.7%         |
|TERMINAL (d)       |     1/12 (8%)    6/16 (38%)   5/21 (24%)   7/31 (23%)  |3/28 (11%)   4/33 (12%)   3/34 (9%)    2/28 (7%)    |
|FIRST INCIDENCE    |     535          450          593          544         |585          738 (T)      738 (T)      586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.230N     P=0.191      P=0.366      P=0.492N    |P=0.353N     P=0.407N     P=0.273N     P=0.494N     |
|POLY 3             |     P=0.400      P=0.106      P=0.196      P=0.363     |P=0.367N     P=0.485N     P=0.340N     P=0.507N     |
|POLY 1.5           |     P=0.338      P=0.116      P=0.195      P=0.322     |P=0.363N     P=0.496N     P=0.348N     P=0.502N     |
|POLY 6             |     P=0.499      P=0.095      P=0.203      P=0.426     |P=0.377N     P=0.465N     P=0.329N     P=0.518N     |
|LOGISTIC REGRESSION|     P=0.385      P=0.117      P=0.200      P=0.320     |P=0.369N     P=0.466N     P=0.328N     P=0.503N     |
|COCH-ARM / FISHERS |     P=0.273      P=0.131      P=0.194      P=0.277     |P=0.363N     P=0.500N     P=0.357N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         2.6%         2.3%        |4.9%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    1/31 (3%)   |2/28 (7%)    1/33 (3%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      688          736 (T)     |738 (T)      738 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491      P=0.557      P=0.515      P=0.689     |P=0.052N     P=0.442N     P=0.196N     P=0.238N     |
|POLY 3             |     P=0.360      P=0.493      P=0.505      P=0.530     |P=0.060N     P=0.486N     P=0.227N     P=0.239N     |
|POLY 1.5           |     P=0.333      P=0.496      P=0.503      P=0.516     |P=0.059N     P=0.495N     P=0.232N     P=0.238N     |
|POLY 6             |     P=0.404      P=0.491      P=0.511      P=0.551     |P=0.062N     P=0.471N     P=0.220N     P=0.242N     |
|LOGISTIC REGRESSION|     P=0.396      P=0.557      P=0.504      P=0.689     |P=0.052N     P=0.442N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.301      P=0.500      P=0.500      P=0.500     |P=0.059N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |6/50 (12%)   6/50 (12%)   3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|                                                        |14.6%        14.0%        7.0%         9.7%         |
|TERMINAL (d)       |                                                        |6/28 (21%)   4/33 (12%)   3/34 (9%)    3/28 (11%)   |
|FIRST INCIDENCE    |                                                        |738 (T)      715          738 (T)      592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.181N     P=0.498N     P=0.151N     P=0.364N     |
|POLY 3             |                                                        |P=0.189N     P=0.591N     P=0.219N     P=0.366N     |
|POLY 1.5           |                                                        |P=0.190N     P=0.610N     P=0.230N     P=0.367N     |
|POLY 6             |                                                        |P=0.191N     P=0.557N     P=0.203N     P=0.370N     |
|LOGISTIC REGRESSION|                                                        |P=0.202N     P=0.508N     P=0.151N     P=0.388N     |
|COCH-ARM / FISHERS |                                                        |P=0.194N     P=0.620N     P=0.243N     P=0.370N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |6/50 (12%)   6/50 (12%)   4/50 (8%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |14.6%        14.0%        9.3%         12.1%        |
|TERMINAL (d)       |                                                        |6/28 (21%)   4/33 (12%)   4/34 (12%)   4/28 (14%)   |
|FIRST INCIDENCE    |                                                        |738 (T)      715          738 (T)      592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.328N     P=0.498N     P=0.249N     P=0.497N     |
|POLY 3             |                                                        |P=0.336N     P=0.591N     P=0.340N     P=0.498N     |
|POLY 1.5           |                                                        |P=0.335N     P=0.610N     P=0.354N     P=0.497N     |
|POLY 6             |                                                        |P=0.341N     P=0.557N     P=0.321N     P=0.503N     |
|LOGISTIC REGRESSION|                                                        |P=0.359N     P=0.508N     P=0.249N     P=0.525N     |
|COCH-ARM / FISHERS |                                                        |P=0.340N     P=0.620N     P=0.370N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          698          708         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.136      (e)          P=0.524      P=0.424     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.076      (e)          P=0.505      P=0.273     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.068      (e)          P=0.503      P=0.256     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.091      (e)          P=0.510      P=0.301     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.090      (e)          P=0.507      P=0.320     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.059      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  26/50 (52%)  26/50 (52%)  23/50 (46%) |15/50 (30%)  15/50 (30%)  15/50 (30%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     58.8%        61.5%        57.8%        48.9%       |33.9%        32.6%        32.0%        39.7%        |
|TERMINAL (d)       |     5/12 (42%)   8/16 (50%)   8/21 (38%)   11/31 (36%) |5/28 (18%)   6/33 (18%)   7/34 (21%)   8/28 (29%)   |
|FIRST INCIDENCE    |     561          507          482          518         |475          392          451          459          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.011N*    P=0.544N     P=0.351N     P=0.013N*   |P=0.311      P=0.436N     P=0.442N     P=0.345      |
|POLY 3             |     P=0.158N     P=0.485      P=0.552N     P=0.231N    |P=0.323      P=0.537N     P=0.511N     P=0.361      |
|POLY 1.5           |     P=0.242N     P=0.490      P=0.572      P=0.308N    |P=0.314      P=0.564N     P=0.543N     P=0.353      |
|POLY 6             |     P=0.086N     P=0.495      P=0.488N     P=0.153N    |P=0.325      P=0.501N     P=0.476N     P=0.364      |
|LOGISTIC REGRESSION|     P=0.306N     P=0.454      P=0.510      P=0.338N    |P=0.286      P=0.581      P=0.550      P=0.335      |
|COCH-ARM / FISHERS |     P=0.376N     P=0.500      P=0.500      P=0.421N    |P=0.293      P=0.586N     P=0.586N     P=0.335      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.9%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          613          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.052      (e)          (e)          P=0.237      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.057      (e)          (e)          P=0.237      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.056      (e)          (e)          P=0.238      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.059      (e)          (e)          P=0.235      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.056      (e)          (e)          P=0.238      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.056      (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         5.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     617          ---          593          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.461N     P=0.517N     P=0.490      P=0.470N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.447N     P=0.509N     P=0.511      P=0.472N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.472N     P=0.505N     P=0.506      P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.410N     P=0.513N     P=0.521      P=0.453N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.535N     P=0.493N     P=0.491      P=0.527N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  50/50 (100%) 48/50 (96%)  48/50 (96%) |37/50 (74%)  37/50 (74%)  27/50 (54%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     99.3%        100.0%       99.2%        98.7%       |80.3%        81.7%        58.0%        67.5%        |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|23/28 (82%)  28/33 (85%)  19/34 (56%)  20/28 (71%)  |
|FIRST INCIDENCE    |     396          410          443          518         |507          522          417          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.499N     P=0.113N     P<0.001N**  |P=0.045N*    P=0.224N     P=0.011N*    P=0.168N     |
|POLY 3             |     P=0.453N     P=0.992      P=0.991N     P=0.868N    |P=0.015N*    P=0.536      P=0.014N*    P=0.111N     |
|POLY 1.5           |     P=0.480N     P=0.593      P=0.866N     P=0.821N    |P=0.015N*    P=0.537      P=0.018N*    P=0.098N     |
|POLY 6             |     P=0.515N     P=1.000      P=1.000N     P=0.973N    |P=0.021N*    P=0.557      P=0.011N*    P=0.153N     |
|LOGISTIC REGRESSION|     P=0.189N     P=0.313      P=0.553N     P=0.481N    |P=0.019N*    P=0.555N     P=0.023N*    P=0.092N     |
|COCH-ARM / FISHERS |     P=0.426N     P=0.247      P=0.691N     P=0.691N    |P=0.023N*    P=0.590N     P=0.030N*    P=0.101N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/50 (64%)  37/50 (74%)  36/50 (72%)  32/50 (64%) |20/50 (40%)  18/50 (36%)  23/50 (46%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     71.3%        81.3%        75.3%        67.3%       |45.2%        39.1%        48.6%        51.4%        |
|TERMINAL (d)       |     7/12 (58%)   11/16 (69%)  12/21 (57%)  18/31 (58%) |10/28 (36%)  9/33 (27%)   12/34 (35%)  10/28 (36%)  |
|FIRST INCIDENCE    |     396          450          360          518         |475          392          451          459          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005N**   P=0.392      P=0.429N     P=0.007N**  |P=0.188      P=0.268N     P=0.562      P=0.296      |
|POLY 3             |     P=0.274N     P=0.174      P=0.416      P=0.424N    |P=0.210      P=0.355N     P=0.455      P=0.352      |
|POLY 1.5           |     P=0.374N     P=0.173      P=0.343      P=0.503N    |P=0.186      P=0.388N     P=0.405      P=0.318      |
|POLY 6             |     P=0.170N     P=0.206      P=0.526      P=0.322N    |P=0.236      P=0.312N     P=0.517      P=0.392      |
|LOGISTIC REGRESSION|     P=0.456N     P=0.171      P=0.259      P=0.506N    |P=0.151      P=0.418N     P=0.337      P=0.273      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.194      P=0.260      P=0.582N    |P=0.153      P=0.418N     P=0.343      P=0.273      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 48/50 (96%) |45/50 (90%)  43/50 (86%)  42/50 (84%)  43/50 (86%)  |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       98.7%       |94.2%        89.9%        85.4%        87.4%        |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|26/28 (93%)  29/33 (88%)  27/34 (79%)  22/28 (79%)  |
|FIRST INCIDENCE    |     396          410          360          518         |475          392          417          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   (e)          (e)          P<0.001N**  |P=0.389N     P=0.131N     P=0.100N     P=0.469N     |
|POLY 3             |     P=0.262N     (e)          (e)          P=0.728N    |P=0.124N     P=0.340N     P=0.132N     P=0.203N     |
|POLY 1.5           |     P=0.157N     (e)          (e)          P=0.530N    |P=0.167N     P=0.372N     P=0.176N     P=0.259N     |
|POLY 6             |     P=0.467N     (e)          (e)          P=0.959N    |P=0.096N     P=0.308N     P=0.103N     P=0.164N     |
|LOGISTIC REGRESSION|     P=0.051N     (e)          (e)          P=0.192N    |P=0.278N     P=0.401N     P=0.246N     P=0.375N     |
|COCH-ARM / FISHERS |     P=0.056N     (e)          (e)          P=0.247N    |P=0.289N     P=0.380N     P=0.277N     P=0.380N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).