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TDMS Study 89002-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Skin                                   Keratoacanthoma
Testes                                 Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Mesothelioma: Benign, Malignant, NOS
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)        -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  14/50 (28%)              16/50 (32%)  |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  35.0%                    37.8%        |           0.0%                     2.4%            |
|TERMINAL (d)       |                  5/12 (42%)               10/27 (37%)  |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  579                      684          |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.142N     |                                    P=0.500         |
|POLY 3             |                                           P=0.484      |                                    P=0.500         |
|POLY 1.5           |                                           P=0.446      |                                    P=0.500         |
|POLY 6             |                                           P=0.548      |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.566N     |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.414      |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     7.2%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  736 (T)                  680          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.563      |                                    (e)             |
|POLY 3             |                                           P=0.337      |                                    (e)             |
|POLY 1.5           |                                           P=0.320      |                                    (e)             |
|POLY 6             |                                           P=0.366      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.424      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.309      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  16/50 (32%)              18/50 (36%)  |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  39.9%                    42.3%        |           0.0%                     2.4%            |
|TERMINAL (d)       |                  6/12 (50%)               11/27 (41%)  |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  579                      680          |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.106N     |                                    P=0.500         |
|POLY 3             |                                           P=0.499      |                                    P=0.500         |
|POLY 1.5           |                                           P=0.455      |                                    P=0.500         |
|POLY 6             |                                           P=0.575      |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.527N     |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.417      |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.6%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      265          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.242      |                                    (e)             |
|POLY 3             |                                           P=0.256      |                                    (e)             |
|POLY 1.5           |                                           P=0.247      |                                    (e)             |
|POLY 6             |                                           P=0.272      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.286      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  4/50 (8%)                4/49 (8%)    |           4/50 (8%)                5/49 (10%)      |
|POLY-3 ADJUSTED (b)|                  10.5%                    9.6%         |           9.7%                     11.7%           |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           3/28 (11%)               1/27 (4%)       |
|FIRST INCIDENCE    |                  647                      550          |           645                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.408N     |                                    P=0.510         |
|POLY 3             |                                           P=0.585N     |                                    P=0.519         |
|POLY 1.5           |                                           P=0.620N     |                                    P=0.503         |
|POLY 6             |                                           P=0.530N     |                                    P=0.534         |
|LOGISTIC REGRESSION|                                           P=0.634      |                                    P=0.488         |
|COCH-ARM / FISHERS |                                           P=0.631      |                                    P=0.487         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/49 (4%)    |           2/50 (4%)                1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.6%                     4.8%         |           4.9%                     2.4%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           1/28 (4%)                0/27 (0%)       |
|FIRST INCIDENCE    |                  396                      536          |           715                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.588      |                                    P=0.489N        |
|POLY 3             |                                           P=0.519      |                                    P=0.491N        |
|POLY 1.5           |                                           P=0.506      |                                    P=0.502N        |
|POLY 6             |                                           P=0.542      |                                    P=0.480N        |
|LOGISTIC REGRESSION|                                           P=0.481      |                                    P=0.507N        |
|COCH-ARM / FISHERS |                                           P=0.492      |                                    P=0.508N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               5/49 (10%)   |           6/50 (12%)               6/49 (12%)      |
|POLY-3 ADJUSTED (b)|                  12.8%                    11.8%        |           14.4%                    13.9%           |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           4/28 (14%)               1/27 (4%)       |
|FIRST INCIDENCE    |                  396                      536          |           645                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.420N     |                                    P=0.602N        |
|POLY 3             |                                           P=0.570N     |                                    P=0.590N        |
|POLY 1.5           |                                           P=0.608N     |                                    P=0.613N        |
|POLY 6             |                                           P=0.509N     |                                    P=0.566N        |
|LOGISTIC REGRESSION|                                           P=0.580      |                                    P=0.607         |
|COCH-ARM / FISHERS |                                           P=0.617      |                                    P=0.606         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      614          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.339      |                                    (e)             |
|POLY 3             |                                           P=0.252      |                                    (e)             |
|POLY 1.5           |                                           P=0.244      |                                    (e)             |
|POLY 6             |                                           P=0.267      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.240      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  695                      736 (T)      |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.722      |                                    (e)             |
|POLY 3             |                                           P=0.525      |                                    (e)             |
|POLY 1.5           |                                           P=0.512      |                                    (e)             |
|POLY 6             |                                           P=0.548      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.617      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  695                      736 (T)      |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.722      |                                    (e)             |
|POLY 3             |                                           P=0.525      |                                    (e)             |
|POLY 1.5           |                                           P=0.512      |                                    (e)             |
|POLY 6             |                                           P=0.548      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.617      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           4.8%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           645                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.232N        |
|POLY 3             |                                           (e)          |                                    P=0.228N        |
|POLY 1.5           |                                           (e)          |                                    P=0.234N        |
|POLY 6             |                                           (e)          |                                    P=0.223N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.236N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           3/50 (6%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           7.2%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           645                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.118N        |
|POLY 3             |                                           (e)          |                                    P=0.112N        |
|POLY 1.5           |                                           (e)          |                                    P=0.117N        |
|POLY 6             |                                           (e)          |                                    P=0.108N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.115N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.121N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               2/50 (4%)    |           25/50 (50%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  13.0%                    4.8%         |           56.7%                    34.6%           |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           16/28 (57%)              11/28 (39%)     |
|FIRST INCIDENCE    |                  619                      715          |           507                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.081N     |                                    P=0.036N*       |
|POLY 3             |                                           P=0.177N     |                                    P=0.027N*       |
|POLY 1.5           |                                           P=0.196N     |                                    P=0.030N*       |
|POLY 6             |                                           P=0.149N     |                                    P=0.025N*       |
|LOGISTIC REGRESSION|                                           P=0.175N     |                                    P=0.022N*       |
|COCH-ARM / FISHERS |                                           P=0.218N     |                                    P=0.033N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               2/50 (4%)    |           25/50 (50%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  13.0%                    4.8%         |           56.7%                    34.6%           |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           16/28 (57%)              11/28 (39%)     |
|FIRST INCIDENCE    |                  619                      715          |           507                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.081N     |                                    P=0.036N*       |
|POLY 3             |                                           P=0.177N     |                                    P=0.027N*       |
|POLY 1.5           |                                           P=0.196N     |                                    P=0.030N*       |
|POLY 6             |                                           P=0.149N     |                                    P=0.025N*       |
|LOGISTIC REGRESSION|                                           P=0.175N     |                                    P=0.022N*       |
|COCH-ARM / FISHERS |                                           P=0.218N     |                                    P=0.033N*       |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               2/50 (4%)    |           25/50 (50%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  13.0%                    4.8%         |           56.7%                    34.6%           |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           16/28 (57%)              11/28 (39%)     |
|FIRST INCIDENCE    |                  619                      715          |           507                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.081N     |                                    P=0.036N*       |
|POLY 3             |                                           P=0.177N     |                                    P=0.027N*       |
|POLY 1.5           |                                           P=0.196N     |                                    P=0.030N*       |
|POLY 6             |                                           P=0.149N     |                                    P=0.025N*       |
|LOGISTIC REGRESSION|                                           P=0.175N     |                                    P=0.022N*       |
|COCH-ARM / FISHERS |                                           P=0.218N     |                                    P=0.033N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                5/50 (10%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     11.6%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  643                      460          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.210      |                                    (e)             |
|POLY 3             |                                           P=0.128      |                                    (e)             |
|POLY 1.5           |                                           P=0.115      |                                    (e)             |
|POLY 6             |                                           P=0.153      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.093      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.102      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           2/50 (4%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     4.8%         |           4.9%                     2.3%            |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  702                      736 (T)      |           738 (T)                  724             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.419N     |                                    P=0.500N        |
|POLY 3             |                                           P=0.648N     |                                    P=0.484N        |
|POLY 1.5           |                                           P=0.671N     |                                    P=0.494N        |
|POLY 6             |                                           P=0.609N     |                                    P=0.473N        |
|LOGISTIC REGRESSION|                                           P=0.541N     |                                    P=0.482N        |
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           2/50 (4%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     4.8%         |           4.9%                     4.7%            |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  702                      736 (T)      |           738 (T)                  701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.419N     |                                    P=0.679N        |
|POLY 3             |                                           P=0.648N     |                                    P=0.677N        |
|POLY 1.5           |                                           P=0.671N     |                                    P=0.687N        |
|POLY 6             |                                           P=0.609N     |                                    P=0.666N        |
|LOGISTIC REGRESSION|                                           P=0.541N     |                                    P=0.675N        |
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.691N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     0.0%         |           0.0%                     2.4%            |
|TERMINAL (d)       |                  1/12 (8%)                0/27 (0%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  660                      ---          |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.132N     |                                    P=0.500         |
|POLY 3             |                                           P=0.206N     |                                    P=0.500         |
|POLY 1.5           |                                           P=0.221N     |                                    P=0.500         |
|POLY 6             |                                           P=0.183N     |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.209N     |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  18/50 (36%)              16/50 (32%)  |           22/50 (44%)              18/50 (36%)     |
|POLY-3 ADJUSTED (b)|                  41.5%                    36.6%        |           49.1%                    41.5%           |
|TERMINAL (d)       |                  4/12 (33%)               7/27 (26%)   |           11/28 (39%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  396                      565          |           507                      652             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.082N     |                                    P=0.262N        |
|POLY 3             |                                           P=0.400N     |                                    P=0.307N        |
|POLY 1.5           |                                           P=0.420N     |                                    P=0.299N        |
|POLY 6             |                                           P=0.347N     |                                    P=0.332N        |
|LOGISTIC REGRESSION|                                           P=0.438N     |                                    P=0.239N        |
|COCH-ARM / FISHERS |                                           P=0.417N     |                                    P=0.270N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  18/50 (36%)              16/50 (32%)  |           22/50 (44%)              18/50 (36%)     |
|POLY-3 ADJUSTED (b)|                  41.5%                    36.6%        |           49.1%                    41.5%           |
|TERMINAL (d)       |                  4/12 (33%)               7/27 (26%)   |           11/28 (39%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  396                      565          |           507                      652             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.082N     |                                    P=0.262N        |
|POLY 3             |                                           P=0.400N     |                                    P=0.307N        |
|POLY 1.5           |                                           P=0.420N     |                                    P=0.299N        |
|POLY 6             |                                           P=0.347N     |                                    P=0.332N        |
|LOGISTIC REGRESSION|                                           P=0.438N     |                                    P=0.239N        |
|COCH-ARM / FISHERS |                                           P=0.417N     |                                    P=0.270N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.7%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  684                      592          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.628      |                                    (e)             |
|POLY 3             |                                           P=0.528      |                                    (e)             |
|POLY 1.5           |                                           P=0.514      |                                    (e)             |
|POLY 6             |                                           P=0.552      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.503      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                4/50 (8%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     9.4%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  684                      592          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.312      |                                    (e)             |
|POLY 3             |                                           P=0.210      |                                    (e)             |
|POLY 1.5           |                                           P=0.194      |                                    (e)             |
|POLY 6             |                                           P=0.240      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.184      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.181      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                4/50 (8%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     9.4%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  684                      592          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.312      |                                    (e)             |
|POLY 3             |                                           P=0.210      |                                    (e)             |
|POLY 1.5           |                                           P=0.194      |                                    (e)             |
|POLY 6             |                                           P=0.240      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.184      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.181      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/50 (6%)                9/50 (18%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  8.0%                     21.1%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  2/12 (17%)               4/27 (15%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  684                      592          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.297      |                                    (e)             |
|POLY 3             |                                           P=0.087      |                                    (e)             |
|POLY 1.5           |                                           P=0.072      |                                    (e)             |
|POLY 6             |                                           P=0.119      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.102      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.061      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.2%                     2.4%         |           4.8%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  603                      614          |           523                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.447N     |                                    P=0.240N        |
|POLY 3             |                                           P=0.455N     |                                    P=0.231N        |
|POLY 1.5           |                                           P=0.478N     |                                    P=0.236N        |
|POLY 6             |                                           P=0.421N     |                                    P=0.226N        |
|LOGISTIC REGRESSION|                                           P=0.520N     |                                    P=0.226N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.247N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               2/50 (4%)    |           3/50 (6%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  13.1%                    4.7%         |           7.2%                     2.3%            |
|TERMINAL (d)       |                  2/12 (17%)               0/27 (0%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  603                      614          |           523                      516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.098N     |                                    P=0.306N        |
|POLY 3             |                                           P=0.171N     |                                    P=0.290N        |
|POLY 1.5           |                                           P=0.193N     |                                    P=0.300N        |
|POLY 6             |                                           P=0.140N     |                                    P=0.280N        |
|LOGISTIC REGRESSION|                                           P=0.207N     |                                    P=0.289N        |
|COCH-ARM / FISHERS |                                           P=0.218N     |                                    P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           1/50 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     2.4%         |           2.4%                     2.3%            |
|TERMINAL (d)       |                  2/12 (17%)               0/27 (0%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  736 (T)                  680          |           738 (T)                  516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.288N     |                                    P=0.758N        |
|POLY 3             |                                           P=0.449N     |                                    P=0.744N        |
|POLY 1.5           |                                           P=0.474N     |                                    P=0.754N        |
|POLY 6             |                                           P=0.408N     |                                    P=0.735N        |
|LOGISTIC REGRESSION|                                           P=0.405N     |                                    P=0.755N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.753N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)    |           1/50 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  8.0%                     2.4%         |           2.4%                     2.3%            |
|TERMINAL (d)       |                  2/12 (17%)               0/27 (0%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  695                      680          |           738 (T)                  516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.135N     |                                    P=0.758N        |
|POLY 3             |                                           P=0.259N     |                                    P=0.744N        |
|POLY 1.5           |                                           P=0.281N     |                                    P=0.754N        |
|POLY 6             |                                           P=0.224N     |                                    P=0.735N        |
|LOGISTIC REGRESSION|                                           P=0.228N     |                                    P=0.755N        |
|COCH-ARM / FISHERS |                                           P=0.309N     |                                    P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                7/50 (14%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     16.7%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                4/27 (15%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      708          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.061      |                                    (e)             |
|POLY 3             |                                           P=0.011 *    |                                    (e)             |
|POLY 1.5           |                                           P=0.009 **   |                                    (e)             |
|POLY 6             |                                           P=0.015 *    |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.025 *    |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.006 **   |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     0.0%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  2/12 (17%)               0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  736 (T)                  ---          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.085N     |                                    (e)             |
|POLY 3             |                                           P=0.204N     |                                    (e)             |
|POLY 1.5           |                                           P=0.220N     |                                    (e)             |
|POLY 6             |                                           P=0.179N     |                                    (e)             |
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                7/50 (14%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     16.7%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  2/12 (17%)               4/27 (15%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  736 (T)                  708          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.353      |                                    (e)             |
|POLY 3             |                                           P=0.103      |                                    (e)             |
|POLY 1.5           |                                           P=0.090      |                                    (e)             |
|POLY 6             |                                           P=0.130      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.208      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.080      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                7/50 (14%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     16.7%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  2/12 (17%)               4/27 (15%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  736 (T)                  708          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.353      |                                    (e)             |
|POLY 3             |                                           P=0.103      |                                    (e)             |
|POLY 1.5           |                                           P=0.090      |                                    (e)             |
|POLY 6             |                                           P=0.130      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.208      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.080      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      661          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.328      |                                    (e)             |
|POLY 3             |                                           P=0.252      |                                    (e)             |
|POLY 1.5           |                                           P=0.244      |                                    (e)             |
|POLY 6             |                                           P=0.267      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.246      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  42/50 (84%)              45/50 (90%)  |                                                    |
|POLY-3 ADJUSTED (b)|                  93.8%                    96.3%        |                                                    |
|TERMINAL (d)       |                  12/12 (100%)             27/27 (100%) |                                                    |
|FIRST INCIDENCE    |                  561                      502          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.004N**   |                                                    |
|POLY 3             |                                           P=0.448      |                                                    |
|POLY 1.5           |                                           P=0.320      |                                                    |
|POLY 6             |                                           P=0.744      |                                                    |
|LOGISTIC REGRESSION|                                           P=0.410      |                                                    |
|COCH-ARM / FISHERS |                                           P=0.277      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               4/50 (8%)    |           3/50 (6%)                7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  12.9%                    9.6%         |           7.2%                     16.3%           |
|TERMINAL (d)       |                  1/12 (8%)                3/27 (11%)   |           1/28 (4%)                4/28 (14%)      |
|FIRST INCIDENCE    |                  535                      675          |           585                      668             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.235N     |                                    P=0.186         |
|POLY 3             |                                           P=0.447N     |                                    P=0.167         |
|POLY 1.5           |                                           P=0.474N     |                                    P=0.160         |
|POLY 6             |                                           P=0.402N     |                                    P=0.174         |
|LOGISTIC REGRESSION|                                           P=0.471N     |                                    P=0.166         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.159         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           2/50 (4%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           4.9%                     2.4%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           2/28 (7%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           738 (T)                  738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.500N        |
|POLY 3             |                                           (e)          |                                    P=0.484N        |
|POLY 1.5           |                                           (e)          |                                    P=0.494N        |
|POLY 6             |                                           (e)          |                                    P=0.474N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.500N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               4/50 (8%)    |           5/50 (10%)               8/50 (16%)      |
|POLY-3 ADJUSTED (b)|                  12.9%                    9.6%         |           12.0%                    18.6%           |
|TERMINAL (d)       |                  1/12 (8%)                3/27 (11%)   |           3/28 (11%)               5/28 (18%)      |
|FIRST INCIDENCE    |                  535                      675          |           585                      668             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.235N     |                                    P=0.304         |
|POLY 3             |                                           P=0.447N     |                                    P=0.292         |
|POLY 1.5           |                                           P=0.474N     |                                    P=0.281         |
|POLY 6             |                                           P=0.402N     |                                    P=0.304         |
|LOGISTIC REGRESSION|                                           P=0.471N     |                                    P=0.298         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.277         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.8%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      711          |           738 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.385      |                                    P=0.500N        |
|POLY 3             |                                           P=0.251      |                                    P=0.487N        |
|POLY 1.5           |                                           P=0.243      |                                    P=0.495N        |
|POLY 6             |                                           P=0.265      |                                    P=0.478N        |
|LOGISTIC REGRESSION|                                           P=0.312      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     7.2%         |           4.9%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      711          |           738 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.267      |                                    P=0.238N        |
|POLY 3             |                                           P=0.132      |                                    P=0.226N        |
|POLY 1.5           |                                           P=0.125      |                                    P=0.233N        |
|POLY 6             |                                           P=0.147      |                                    P=0.219N        |
|LOGISTIC REGRESSION|                                           P=0.197      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.121      |                                    P=0.247N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           6/50 (12%)               6/50 (12%)      |
|POLY-3 ADJUSTED (b)|                                                        |           14.6%                    13.9%           |
|TERMINAL (d)       |                                                        |           6/28 (21%)               4/28 (14%)      |
|FIRST INCIDENCE    |                                                        |           738 (T)                  600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.611N        |
|POLY 3             |                                                        |                                    P=0.585N        |
|POLY 1.5           |                                                        |                                    P=0.606N        |
|POLY 6             |                                                        |                                    P=0.561N        |
|LOGISTIC REGRESSION|                                                        |                                    P=0.581N        |
|COCH-ARM / FISHERS |                                                        |                                    P=0.620N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           6/50 (12%)               7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                                                        |           14.6%                    16.2%           |
|TERMINAL (d)       |                                                        |           6/28 (21%)               4/28 (14%)      |
|FIRST INCIDENCE    |                                                        |           738 (T)                  600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.518         |
|POLY 3             |                                                        |                                    P=0.538         |
|POLY 1.5           |                                                        |                                    P=0.516         |
|POLY 6             |                                                        |                                    P=0.564         |
|LOGISTIC REGRESSION|                                                        |                                    P=0.541         |
|COCH-ARM / FISHERS |                                                        |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  25/50 (50%)              15/50 (30%)  |           15/50 (30%)              11/50 (22%)     |
|POLY-3 ADJUSTED (b)|                  58.8%                    34.5%        |           33.9%                    24.4%           |
|TERMINAL (d)       |                  5/12 (42%)               8/27 (30%)   |           5/28 (18%)               2/28 (7%)       |
|FIRST INCIDENCE    |                  561                      536          |           475                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.231N        |
|POLY 3             |                                           P=0.016N*    |                                    P=0.221N        |
|POLY 1.5           |                                           P=0.022N*    |                                    P=0.238N        |
|POLY 6             |                                           P=0.011N*    |                                    P=0.208N        |
|LOGISTIC REGRESSION|                                           P=0.018N*    |                                    P=0.247N        |
|COCH-ARM / FISHERS |                                           P=0.033N*    |                                    P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                9/50 (18%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.6%                     20.6%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                4/27 (15%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  617                      502          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.049 *    |                                    (e)             |
|POLY 3             |                                           P=0.014 *    |                                    (e)             |
|POLY 1.5           |                                           P=0.011 *    |                                    (e)             |
|POLY 6             |                                           P=0.021 *    |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.009 **   |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.008 **   |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  48/50 (96%)              47/50 (94%)  |           37/50 (74%)              35/50 (70%)     |
|POLY-3 ADJUSTED (b)|                  99.3%                    99.1%        |           80.3%                    76.9%           |
|TERMINAL (d)       |                  12/12 (100%)             27/27 (100%) |           23/28 (82%)              22/28 (79%)     |
|FIRST INCIDENCE    |                  396                      502          |           507                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.379N        |
|POLY 3             |                                           P=0.993N     |                                    P=0.443N        |
|POLY 1.5           |                                           P=0.812N     |                                    P=0.445N        |
|POLY 6             |                                           P=1.000N     |                                    P=0.466N        |
|LOGISTIC REGRESSION|                                           P=0.401N     |                                    P=0.352N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.412N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  32/50 (64%)              29/50 (58%)  |           20/50 (40%)              16/50 (32%)     |
|POLY-3 ADJUSTED (b)|                  71.3%                    61.8%        |           45.2%                    34.3%           |
|TERMINAL (d)       |                  7/12 (58%)               14/27 (52%)  |           10/28 (36%)              3/28 (11%)      |
|FIRST INCIDENCE    |                  396                      265          |           475                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.013N*    |                                    P=0.251N        |
|POLY 3             |                                           P=0.219N     |                                    P=0.195N        |
|POLY 1.5           |                                           P=0.268N     |                                    P=0.232N        |
|POLY 6             |                                           P=0.163N     |                                    P=0.160N        |
|LOGISTIC REGRESSION|                                           P=0.337N     |                                    P=0.267N        |
|COCH-ARM / FISHERS |                                           P=0.341N     |                                    P=0.266N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  50/50 (100%)             49/50 (98%)  |           45/50 (90%)              42/50 (84%)     |
|POLY-3 ADJUSTED (b)|                  100.0%                   99.8%        |           94.2%                    86.6%           |
|TERMINAL (d)       |                  12/12 (100%)             27/27 (100%) |           26/28 (93%)              22/28 (79%)     |
|FIRST INCIDENCE    |                  396                      265          |           475                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.002N**   |                                    P=0.315N        |
|POLY 3             |                                           P=1.000N     |                                    P=0.170N        |
|POLY 1.5           |                                           P=0.973N     |                                    P=0.226N        |
|POLY 6             |                                           P=1.000N     |                                    P=0.140N        |
|LOGISTIC REGRESSION|                                           P=0.680N     |                                    P=0.284N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.277N        |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).