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TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 11:09:53

                                                     Control vs Stop Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 009    1000 PPM
                               Include 010    1000 PPM
































                                                              Page   1


NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|             
                             DAY ON TEST   | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|             
                                           | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X  X  X  X  X  X  X  X  X  X  X     X  X  X     X  X  X  X  X   |             
      Clear Cell Focus                     |          X  X     X           X                 X  X           X         |             
      Eosinophilic Focus                   |                                                    X                     |             
      Hepatodiaphragmatic Nodule           |             X           X                                      X         |             
      Inflammation, Chronic                |          1  1     1  1     2  2     2  1     2  2  2        1  1     1   |             
      Mixed Cell Focus                     |             X        X                          X              X         |             
      Pigmentation, Hemosiderin            | 2                                                                        |             
      Thrombosis                           |                                  2                                       |             
      Bile Duct, Hyperplasia               | 2     2  1  1     1  1  1        1        1        1  2     1  1     1   |             
      Hepatocyte, Vacuolization Cytoplasmic|       3              1           2        2                    1         |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +  +                                                |             
      Accessory Spleen                     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                      4  4                                                |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   2     1     1  1           1        2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              | 2                                                                        |             
      Epithelium, Ulcer                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Erosion                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1        1  1     1     1  1  1  1  1  1  1           1  2     1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|             
                             DAY ON TEST   | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|             
                                           | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atrophy                              |                                                       3                  |             
      Degeneration, Fatty                  |       3     2           1                 1                          2   |             
      Hyperplasia                          |             2     3                                2     1           1   |             
      Hypertrophy                          |                         1                                                |             
      Pigmentation                         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                       3                  |             
      Pars Distalis, Cyst                  | 2  2     3  2     2  1        2     2  2  1        1     1  1  2        2|             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2     3  2  2  2  2           1     3              1     2              2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1     1                    1     1        1     1                  |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2              4     2  2  2  3                          3        2   |             
      Inflammation, Chronic Active         |                1                                            3            |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                              3|             
      Bilateral, Cyst                      |                                     4                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |       +           +                                                      |             
      Hypertrophy                          |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4  4                 4        4        4              3  3           4|             
      Myelofibrosis                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +     +  +  +  +  +  +  +     +     +  +        +|             
      Mediastinal, Pigmentation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|             
                             DAY ON TEST   | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|             
                                           | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      | 1  1  2  1  1     1           1  2  2  1  1  2  2           2  1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2                                                                  |             
      Hematopoietic Cell Proliferation     |                                  2                       1  1            |             
      Necrosis                             |                                                                         1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          4                                                               |             
      Hyperplasia, Cystic                  | 1     3  3  4  2  2  3  2  2  2  2  2  3  4     2        2     2  1  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        | 2           3                       3                 3              3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1     1              1  1     1                 1   |             
      Alveolar Epithelium, Hyperplasia     |          3                             2  3        3        1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     1  2  1  1  2  2  1  1     1  1  1  1  1  1  1  1  1  1  1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                      X                                            X  X   |             
      Inflammation, Chronic Active         |          1  2        2              2                             3  3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2                    3     1                                       |             
      Respiratory Epithelium, Hyperplasia  |          2           3              3                             2  3   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|             
                             DAY ON TEST   | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|             
                                           | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 1  1  1  2  2  1  1  2  1  1  2  1  1  1  1  1  1  1  1  1  2  2     2   |             
      Renal Tubule, Pigmentation           | 1  1  3  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6|            |
                                           | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X     X  X  X  X  X   |     41     |
      Clear Cell Focus                     |             X                             X        X                 X   |     11     |
      Eosinophilic Focus                   |                                                 X                        |      2     |
      Hepatodiaphragmatic Nodule           |       X           X     X                             X  X     X         |      9     |
      Inflammation, Chronic                |    1  2     1  1     1  2  1  1        1  1  1  1  1        3  1     1  1|     31  1.3|
      Mixed Cell Focus                     |                                        X           X     X               |      7     |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Thrombosis                           | 2                                                                        |      2  2.0|
      Bile Duct, Hyperplasia               |          1  1           1  1  1  1  2  1  1              1               |     24  1.2|
      Hepatocyte, Vacuolization Cytoplasmic|                                                    1        3            |      7  1.9|
      Hepatocyte, Centrilobular, Necrosis  | 2              2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +              +                 +                    +               |   8        |
      Accessory Spleen                     |                                                          X               |      1     |
      Artery, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
      Fat, Necrosis                        | 4                                                                        |      3  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       1                 1                             1        2         |     10  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
      Epithelium, Hyperplasia              |                                                             3     2      |      3  2.3|
      Epithelium, Ulcer                    |                   4                                         4            |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Erosion                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6|            |
                                           | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |       1     1        1  2  2  1  1           1     2                 1  1|     27  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                      2   |      1  2.0|
      Atrophy                              |                                                                          |      1  3.0|
      Degeneration, Fatty                  |          1              1           2                          1         |      9  1.6|
      Hyperplasia                          |                                              1                 2         |      7  1.7|
      Hypertrophy                          |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                 2                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |    2  3  2  1  2  1  1  1  2  2  2     2  2  3     3        2  2  2  2  2|     35  1.9|
      Pars Distalis, Hemorrhage            |                                                       4                  |      1  4.0|
      Pars Distalis, Hyperplasia           |    2     1     2  2        2  2  2  2     2        2     2     2  2      |     24  2.0|
      Pars Intermedia, Cyst                |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1     1  1              1        2           1  1        1        1  1|     16  1.1|
      Follicular Cell, Hyperplasia, Cystic |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2  4                                          |     10  2.6|
      Inflammation, Chronic Active         |                         1                                               1|      4  1.5|
      Duct, Cyst                           |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            3                                             |      3  3.0|
      Bilateral, Cyst                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6|            |
                                           | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Hypertrophy                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   4                 4                                    |     11  3.7|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +        +  +     +  +     +        +  +     +|  35        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    2  1  2  2  1     2  1  1           1     1  2     2        2  1     1|     30  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  1           3                       1                 1  1            |      9  1.3|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                      4   |      2  4.0|
      Hyperplasia, Cystic                  |    2  2  2  2  4  2  1  2  3  2  2  2  2  1  2  2  2  3  3  3  2  1     2|     43  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                          3               |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       1                 1  1  1                    1     1               |     12  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  2.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6|            |
                                           | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |    1  1  1  1  1        1  1  1  1     1  1  1  1  2  1  1  1  1     1  1|     41  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |                X                                            X     X      |      6     |
      Inflammation, Chronic Active         |    2  1        3           2  1                             2     2      |     13  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         3  2     1     1     1                 2         |      9  1.8|
      Respiratory Epithelium, Hyperplasia  |    2           3           3                                2     2      |     10  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    2                                                        3     3      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +           +                              |   3        |
      Atrophy                              |                               4           4                              |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            3                                             |      1  3.0|
      Nephropathy, Chronic                 |    1  1  2  2        1  2  1  1  1  1  1  1  1  1  2  1  1  2  1     1  1|     44  1.3|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  2  1|     48  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|             
                                           | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              3                           |             
      Ulcer                                |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X     X     X  X        X        X  X        X|             
      Clear Cell Focus                     |    X     X              X  X           X  X                 X            |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X              X           X  X  X                  |             
      Inflammation, Chronic                | 1  1  1  1  1  1  1  1  1  1  1  1     2  1                 1  1        1|             
      Mixed Cell Focus                     |                         X     X                                          |             
      Pigmentation, Hemosiderin            |                                                                   2      |             
      Bile Duct, Hyperplasia               |                1              1  1                       2              1|             
      Hepatocyte, Necrosis                 |                                     1                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|          1              1     1     3                          1         |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                               2                                          |             
      Kupffer Cell, Hypertrophy            |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +                  |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
      Pharyngeal, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Atrophy                      |                            2              1     1        1              2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                       2     1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Ulcer                    |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |          1           2  1     2           1        2  2     2     1     2|             
      Atrium, Thrombosis                   |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|             
                                           | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                            3                                             |             
      Degeneration, Fatty                  |       1                 2                 1  1        4  2               |             
      Hyperplasia                          |       1              2                          2           1           2|             
      Hypertrophy                          |                         2                                                |             
      Necrosis                             |                               4                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
      Necrosis                             |                               4                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 2        2     2  2           3           4        1  2  3        2     3|             
      Pars Distalis, Hyperplasia           | 2        2  2                    3        2  2     2  3  3     2        3|             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Ectopic Tissue         |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1  1        1  1     1           2  1              1        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2                    2                             2     2           2|             
      Inflammation, Chronic Active         |                            2                                      2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           4                              |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             4     4  4        4     4     4     4     4  4           4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +     +  +     +     +        +  +  +  +  +  +  +  +  +   |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1  1  1     2     1  2     1     2        2     1     1  1  1  1  1   |             
      Renal, Ectasia                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|             
                                           | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2     3           2     3     3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  1  2  1  2  2     2  2     4  4  3  2  2  4  4  1  3  2  2  2  1  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |    1     1        1     1                                      1        1|             
      Alveolar Epithelium, Hyperplasia     |                                     2  2                                2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |    X                                                                 X   |             
      Inflammation, Chronic Active         |    2                             1  1                                3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                  1                 2  1           1      |             
      Respiratory Epithelium, Hyperplasia  |    2                                                                 3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Atrophy                              |                                              4                           |             
      Anterior Chamber, Cornea,            |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|             
                                           | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               3                                          |             
      Nephropathy, Chronic                 | 1  1  1  1  1  2  1  1  3  1  2  2  3  1  1  1  1  1  1  1  1  2  1  2  1|             
      Papilla, Necrosis                    |                               4                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           | 1  1  1  1  2  1  2  1  1  1  1  1  2  1  1  2  3  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                               X                                          |             
      Transitional Epithelium, Hyperplasia |                               3                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4|            |
                                           | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  X                                      X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X        X  X  X  X  X     X  X  X  X  X     X  X  X        X     X  X  X|     34     |
      Clear Cell Focus                     |                X  X           X                 X  X  X     X        X  X|     16     |
      Eosinophilic Focus                   |                                                                   X  X   |      2     |
      Hepatodiaphragmatic Nodule           |          X     X                          X     X        X               |     10     |
      Inflammation, Chronic                | 1        1  1  1  2  1  2  1  2     2  1     1     1  1     3  2  2  1  2|     36  1.3|
      Mixed Cell Focus                     | X                                                           X     X      |      5     |
      Pigmentation, Hemosiderin            |                                           3                              |      2  2.5|
      Bile Duct, Hyperplasia               | 1           1     1  1           1  1        1     1  1  1        1  1  1|     18  1.1|
      Hepatocyte, Necrosis                 |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|             2                                         1  2  1            |      9  1.4|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                                          3               |      2  2.5|
      Kupffer Cell, Hypertrophy            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +  +  +                 +            |   6        |
      Fat, Necrosis                        |                                     4  4                    4            |      3  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |   2        |
      Pharyngeal, Hyperplasia              | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    2                                                                     |      1  2.0|
      Acinus, Atrophy                      |                            1  1  1        4  2  1                 1     1|     13  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                     4     2                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Ulcer                    |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4|            |
                                           | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |          2  2  2  2  1        1     2        2  2  2  2  1  1     1  1   |     25  1.6|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                        2                                 |      2  2.5|
      Degeneration, Fatty                  |             1     1        2  1  3  2                       2     2      |     14  1.8|
      Hyperplasia                          | 2        1     1  2           2  2           1     1  1     3     2  2   |     17  1.6|
      Hypertrophy                          |                   3        2                                             |      3  2.3|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1                          1                                2|      4  1.3|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |       3        2  3     2  1              2     2  1  2  2        1  2  1|     24  2.1|
      Pars Distalis, Hyperplasia           | 2              2  2     2     3  3     2        2     2  2     1     3  2|     24  2.3|
      Pars Intermedia, Cyst                |                               3              3                           |      2  3.0|
      Pars Intermedia, Hyperplasia         |                               2                                          |      1  2.0|
      Pars Nervosa, Ectopic Tissue         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1              1                    1        1     2  1        2     2   |     17  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          3  2                                   2           2            |     10  2.2|
      Inflammation, Chronic Active         |                            1                                             |      3  1.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2     3                 2                    4              2      |      6  2.8|
      Bilateral, Cyst                      |                                     4                                    |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4|            |
                                           | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             4                    4     4  4     3        4               |     16  3.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +              +           +  +  +  +     +     +  +     +  +     +|  30        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 2     2              2           1  2           1     1  1     2  1     1|     26  1.3|
      Renal, Ectasia                       |                                        2                                 |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                        3                 3               |      7  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 1     2  2  2  2  1  2  2  2  2     2  1  1  1  2  2  2  2  2     2  1  2|     45  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Osteopetrosis                        |                                  2                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           2                              |      1  2.0|
      Inflammation, Chronic Active         |             1  1  1           1     2           1     1        1  1      |     15  1.1|
      Alveolar Epithelium, Hyperplasia     |                                              2                    2      |      5  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1     1  1  1  2  1  1  1  1  1  1  2  1     1  2  1  1  1  1     1  1  1|     46  1.1|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4|            |
                                           | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |                                                                          |      2     |
      Inflammation, Chronic Active         |    2              1     1                                                |      7  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2  1                 1        2     1                                1   |     10  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
      Atrophy                              |                                                                          |      1  4.0|
      Anterior Chamber, Cornea,            |                                                                          |            |
          Inflammation, Chronic Active     | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1     2  1  3  1  1  1  3  1  1  1  2  1  2  1  1  1  2  1  2  1  2  1  1|     49  1.4|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Hyperplasia            |                                  2                                       |      1  2.0|
      Renal Tubule, Pigmentation           | 1     1  1  1  1  1  1  2  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|     49  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Gross Observation           |                                                                          |      1     |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  17                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|             
                                           | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Erosion                  |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Basophilic Focus                     |    X                       X        X     X  X              X  X     X  X|             
      Clear Cell Focus                     |                                                                      X  X|             
      Eosinophilic Focus                   |                   X                                                      |             
      Inflammation, Chronic                | 2        1              1  1        2     1  1  1  1        1     1  1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 1  3     1  1  3  2  1  2  1  2  3  1  3  1  2  2  1  3  3  1  2  1  2  1|             
      Hepatocyte, Degeneration, Cystic     |                2     1     3  2  2     2     1  1        3               |             
      Hepatocyte, Necrosis                 |                                     1                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|                         1  1        1           1              1         |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                                                1         |             
      Hepatocyte, Centrilobular, Necrosis  |                               4                                          |             
      Kupffer Cell, Hypertrophy            |          1                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +                          +               |             
      Fat, Necrosis                        |    4                          4                          4               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
      Acinus, Atrophy                      |    2              1                    1              1  1  1  3         |             
      Artery, Inflammation, Chronic Active | 3                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                3                                3  3           3  2      |             
      Epithelium, Hyperplasia              |                2                                3  2           2  2      |             
      Epithelium, Ulcer                    |                4                                4              2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |          2                                                               |             
      Epithelium, Erosion                  |                               2                                          |             
      Epithelium, Ulcer                    |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|             
                                           | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |          3                                                               |             
      Pulmonary Artery, Thrombosis         |                                                          4               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1     2  2  2  2  2  2  2  2  2  2  2        2  2  2  2  2  2     2  2  2|             
      Atrium, Thrombosis                   |                4           2  2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Degeneration, Cystic                 |                            2                                             |             
      Degeneration, Fatty                  |                         1  1  2     1  1  1  1  1  2  1        3  1  1   |             
      Hyperplasia                          | 1           2                          1     2     2              2      |             
      Necrosis                             |                2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1     2              2              1              3     3     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                 2  2        2                 2        3     2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |          3                                         2     2  1  2         |             
      Pars Distalis, Hyperplasia           |    2           3  3              2           2        2  2  1  2  2  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                 2              2              1  1           2  2  2   |             
      Follicular Cell, Hyperplasia, Cystic |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                +                                +                        |             
      Inflammation, Chronic Active         |                4                                4                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                             1           3|             
      Inflammation, Chronic Active         |    2     2     2  2     2  2  2  2  2  2  1  2  2  2  2  2  2  1  2  2  2|             
      Duct, Cyst                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  1     2  2  4  1  2  2        1  2  2  2  1  4  1  2  3        2  1  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|             
                                           | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Germinal Epithelium, Atrophy         |                4                                                         |             
      Interstitial Cell, Hyperplasia       | 1              1     1  1     1  1  1                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4  4  4  3     4     4  3  4  4     4              4  4     4     3   |             
      Myelofibrosis                        |                                                          1               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +     +        +     +  +  +  +     +  +  +     +      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                1  1     1        1        1  1  1     2  1  1     2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          3                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     |                               3                                4         |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  1  2        3     1  2  2     2  3  2  3  2     1  2  2     2  2  1  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                                       3                  |             
      Sebaceous Gland, Hyperplasia         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      X                                                   |             
      Inflammation, Chronic Active         |                                                    1           1         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1           1  1     1  1        1  1  1  1  1  1  1  1     1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|             
                                           | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               |    X  X     X        X              X     X        X        X  X        X|             
      Inflammation, Chronic Active         |    2  3     2        2     2        2     2     1  2        3  4        3|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2     3                                2                        |             
      Respiratory Epithelium, Hyperplasia  |    3        2        2     2        2     2     1  2        3  3        3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2        2        2                    2        2           2        2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Lens, Cataract                       |                                           4                              |             
      Retina, Atrophy                      |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 2  2  2  4  2  3  1  2  2  4  3  3  3  3  2  3  4  4  2  4  3  2  4  2  3|             
      Renal Tubule, Hyperplasia            |                                        3                                 |             
      Renal Tubule, Pigmentation           | 1  1  3  1  1  2  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6|            |
                             DAY ON TEST   | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0|            |
                                           | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Erosion                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              3                           |      2  2.0|
      Basophilic Focus                     |             X              X  X     X     X        X           X     X   |     17     |
      Clear Cell Focus                     |             X                       X     X        X                     |      6     |
      Eosinophilic Focus                   |                               X                                          |      2     |
      Inflammation, Chronic                |             1     2           1     1     1        1     1  2  1         |     22  1.2|
      Mixed Cell Focus                     |                                           X                              |      1     |
      Bile Duct, Hyperplasia               | 2  2  3  3  2  2  1  3  2  2  2  1  2  2  2  3  3  2  3  1  1  1  3  2  2|     49  1.9|
      Hepatocyte, Degeneration, Cystic     |          2              1              2     2        1  1        2      |     16  1.8|
      Hepatocyte, Necrosis                 |       2                                                     2            |      3  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|    1                                                     3  2  1     2   |     10  1.4|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                                             3            |      2  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                               2                                          |      2  3.0|
      Kupffer Cell, Hypertrophy            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +              +  +  +              +  +     +     +     +  +  +|  15        |
      Fat, Necrosis                        | 4        4              4  4  4              4        4     4           4|     12  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |       1     2                 1           1        1                     |     12  1.3|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    3  2              1                                   3        3      |     10  2.6|
      Epithelium, Hyperplasia              |    2  1                                                  3               |      8  2.1|
      Epithelium, Ulcer                    |    4  4              1                                   4        4      |      8  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  22                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6|            |
                             DAY ON TEST   | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0|            |
                                           | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Epithelium, Erosion                  |                                                                         2|      2  2.0|
      Epithelium, Ulcer                    |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
      Pulmonary Artery, Thrombosis         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 1  2  1  2  2  2     3  2  3  2  2  2  2  2  2  2  2     2  2  1     2   |     42  2.0|
      Atrium, Thrombosis                   |       3  2           4                 3                                 |      7  2.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration, Fatty                  | 1  3  1  1     2  1        2  1        2  1        1  2  2     1        2|     28  1.4|
      Hyperplasia                          | 2  2  1     1              1                       1     1               |     13  1.5|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2     1  1  1     2  1     1        1     1        2           2      |     18  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                             3                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  47        |
      Hyperplasia                          |    2                                                  2                  |      9  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Craniopharyngeal Duct, Cyst          |             1                                                            |      1  1.0|
      Pars Distalis, Cyst                  |                                           2        1                     |      7  1.9|
      Pars Distalis, Hyperplasia           | 1     1     1           1     2     1  1     1     1  2              2   |     22  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1     2  2  1           1                 2     1                    2|     16  1.6|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  23                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6|            |
                             DAY ON TEST   | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0|            |
                                           | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                          3                          2     2   |      7  2.4|
      Inflammation, Chronic Active         | 2  2  1  2  2  2     3  1  2  2  1  3  2  2     2  2  2  2  2     2  2   |     42  1.9|
      Duct, Cyst                           |                      4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1  2  1  2  1  2  2  1     2     2  1     2     1     2  2     2  2     1|     38  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |          2                                                               |      1  2.0|
      Germinal Epithelium, Atrophy         |          2                                                               |      2  3.0|
      Interstitial Cell, Hyperplasia       |          2        2                                                     1|     10  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4     4  4     4     4  4     4        3     4     3  4     3  4  3  4  4|     30  3.8|
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +     +  +  +|  34        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    1  2     1     1  1  2     1     1  1     1     2     1  1           1|     25  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |             2              3        1                                   2|      5  2.0|
      Hematopoietic Cell Proliferation     |                                                             2  2         |      4  2.8|
      Necrosis                             |                                                       4                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  | 2  3  2  3     3     2     2  1  2  1  2  3           2  3        2  2  2|     36  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Hyperplasia               |                                                                          |      1  3.0|
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  24                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6|            |
                             DAY ON TEST   | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0|            |
                                           | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 4     2                 4|      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                1         |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1  1  1  1        1  1  1     1  1  1  1  1  1  1     1  1  1  1  1|     39  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |             X  X     X     X  X     X           X  X     X        X  X   |     21     |
      Inflammation, Chronic Active         |             2  2     2     2  4     2  2        4  2     2        3  3  2|     25  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    1     1                                                  1            |      6  1.7|
      Respiratory Epithelium, Hyperplasia  |    2        3  3     2     3  3     3  2           3     2        3  3  1|     24  2.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                               2        2                 2           3  2|     12  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    2                                                                     |      1  2.0|
      Nephropathy, Chronic                 | 1  4  2  2  3  2  2  3  1  2  3  1  2  3  2  2  1  2  2  4  1  1  3  2  2|     50  2.4|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  3  1  1  1  1|     49  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  25                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|             
                                           | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X           X                                         X                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      3   |             
      Parasite Metazoan                    |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |                                                                4         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  1                                                               |             
      Basophilic Focus                     |    X     X  X     X  X  X  X     X  X  X  X  X  X  X  X     X     X      |             
      Clear Cell Focus                     |    X  X     X                             X                       X      |             
      Eosinophilic Focus                   |       X                 X                                         X      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X           X                                                   |             
      Inflammation, Chronic                | 1  1     2  1     2  1           2  1  1  1  1  1  1  2  1     1  2  2  1|             
      Mixed Cell Focus                     |       X                 X                                                |             
      Pigmentation, Bile                   |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  3  2     2  2  3  2  2     2  2  2  2  2  1  2  2  1     1|             
      Hepatocyte, Degeneration, Cystic     |          1     1  1  1  1        1  2        1  1     2     2     1     1|             
      Hepatocyte, Necrosis                 |                                                                1         |             
      Hepatocyte, Vacuolization Cytoplasmic| 1  1     1  2                                      1  1           1      |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                                                4         |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                 +     +  +  +           +              +  +   |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Fat, Necrosis                        |       4  4                 4     4  4              4              4      |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1        1  1  1        1                 1  1  1  2  1  1        2     1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|             
                                           | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                      1        2                                      1   |             
      Epithelium, Ulcer                    |                      4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               3                                          |             
      Mineralization                       |                                                                          |             
      Epithelium, Erosion                  |                                                                2         |             
      Epithelium, Ulcer                    |                               4                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  3  2  2  2  2  1  2  2  2  2  3  2  2     2  2     2     2|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 2                                                                        |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  | 1     1     1     1  1  2     2  2           1  1  2     2  2  2     1  1|             
      Hyperplasia                          | 1           2           2  2  2  2                    1     2            |             
      Hypertrophy                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1  1  1     1        1  3  2     4        2     2  1     1        1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                2     3                                         2         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                         2|             
      Pars Distalis, Cyst                  |                         2  2           1                                 |             
      Pars Distalis, Hyperplasia           | 2  2  3  2           1  2  1           1  2        3  2     2  2  2     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  4  2                 1           1                 2     2     2  1   |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                           1                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|             
                                           | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2     2                                               2               |             
      Inflammation, Chronic Active         | 2  3  2  2  2  1  2     2  3  2  4  2  2  2  2  2  2  3  1  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2  2  2  1     2  2  2  2  2  2  1  1  1  2  2  2  1  2  2        3  1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Arteriole, Necrosis, Fibrinoid       |                                                                          |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1                                               2           1        1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     4        4  4        4  4  2  3  4  3     3  3  3     3  4  2  4  4|             
      Myelofibrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +        +           +  +  +  +  +           +     +  +           +|             
      Inguinal, Inflammation, Suppurative  |                                                                          |             
      Mediastinal, Ectasia                 |                                  2                                       |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                    2                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1  2        1              1  2  1  4           2     1              1|             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          3                             3              3                  |             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      4   |             
      Inflammation, Granulomatous          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2        3                             1                              |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    4                     |             
      Hyperplasia, Cystic                  |    2  1  1           2  2  1  2  1        1  2  2  2     2  2     1      |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|             
                                           | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                  X                                       |             
      Inflammation, Chronic Active         |                                                                   2      |             
      Epidermis, Hyperkeratosis            |                      4        4                                   4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2                                                   |             
      Cranium, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                                     1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1        1  1|             
      Interstitium, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               | X                                            X              X            |             
      Inflammation, Chronic Active         | 2  1     2  1        1        1           1  3              2           2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               3                          2               |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2        3           1                          2           3            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1                                            4                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    M                                                                     |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 2  3  2  2  3  2  2  4  3  3  3  2  2  1  2  2  3  3  2  2  3  3  4  1  2|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|             
                                           | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                4         |             
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  1  1  4  1  1  1  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1000 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      3     |
      Ulcer                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                              X                       X  X|      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | X  X     X  X     X  X  X  X        X        X              X  X     X  X|     31     |
      Clear Cell Focus                     |          X                 X                                   X     X   |      9     |
      Eosinophilic Focus                   |          X           X     X                                            X|      7     |
      Fibrosis                             |                                                                   3      |      1  3.0|
      Hematopoietic Cell Proliferation     |                1                                                         |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X  X                                      X                     |      5     |
      Inflammation, Chronic                | 2     1  1  2  1     1  1  1     1  2        1        1     1  1     1   |     34  1.3|
      Mixed Cell Focus                     |             X              X                                   X         |      5     |
      Pigmentation, Bile                   |                                                    2                     |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1  1  2  2  2  2  2  1  2  1     2  3  2  2  3  3  1  1  2  2  3  2  1|     46  1.9|
      Hepatocyte, Degeneration, Cystic     | 3  1     2     2  2  2  2  1           2  1  1  3     1     1           2|     28  1.5|
      Hepatocyte, Necrosis                 |                                                                   4      |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic| 3           1                                1        2           2     2|     13  1.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                                          3               |      2  3.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |       3                                                                  |      1  3.0|
      Hepatocyte, Centrilobular, Necrosis  |                               4                          2               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +              +           +                 +        +  +            |  15        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Fat, Necrosis                        |                   4           4                 4           4            |     11  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +                 +                                                      |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  31                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1000 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1                          1           2     1           2  1            |     19  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       1                                                                  |      2  2.0|
      Epithelium, Hyperplasia              |       1                                                                  |      4  1.3|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       | 2                       2                                                |      2  2.0|
      Epithelium, Erosion                  |                                                                          |      1  2.0|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                | 2                       2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 3     1  2  2  2  2  2  3  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2|     45  2.0|
      Mineralization                       |                         3                                                |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                 2                        |      2  2.0|
      Degeneration, Cystic                 |                                                                      1   |      1  1.0|
      Degeneration, Fatty                  | 1        2        1     2           2     2     1     1  1               |     25  1.4|
      Hyperplasia                          | 2        2        2        2     1        2           1     1  2         |     17  1.7|
      Hypertrophy                          |                                           2                 1            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  1        1     1  2  2  2     1  2  2  2  1              1        1   |     28  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 3                       2              2        3                        |      7  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Craniopharyngeal Duct, Cyst          |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                            1           1                    2            |      6  1.5|
      Pars Distalis, Hyperplasia           |    2        2  2  1     1  2           2                    2  2     2  2|     26  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  32                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1000 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |    1           2  1                       2  1  1              1        1|     17  1.6|
      Follicular Cell, Hyperplasia, Cystic |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          4           2                 2                    2           2|      8  2.3|
      Inflammation, Chronic Active         | 2  2        2  2  3  2  2  2  2  2  1  2  2  2     2  2     4  2     2  2|     44  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1        2        2  1  2  2     1  2     3  1     1  2     2        2  2|     37  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |                                                       2                  |      1  2.0|
      Arteriole, Necrosis, Fibrinoid       |                                                       2                  |      1  2.0|
      Germinal Epithelium, Atrophy         |                               4        4              2  4               |      4  3.5|
      Interstitial Cell, Hyperplasia       |                                  1  1  1                 1               |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  4     3  3  4  4  4  4  3  3  3     4  4  3     4     4  3  3  4     4|     38  3.5|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +  +  +  +        +        +     +  +  +  +  +  +  +     +   |  28        |
      Inguinal, Inflammation, Suppurative  |                                                 3                        |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                               3                                          |      1  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |    3                                                                     |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    2        1  1  1  1        3              1  1  1  1  1  1  1     2   |     24  1.4|
      Renal, Hyperplasia, Lymphoid         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  33                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1000 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                     3                          2     3   |      6  2.8|
      Erythrophagocytosis                  |                               2                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                               3                                2         |      3  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2        3                                                           3   |      6  2.3|
      Hematopoietic Cell Proliferation     |                3              3                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            4                                             |      2  4.0|
      Hyperplasia, Cystic                  |          3     1     1  2     1     2  2  2                 1  1        2|     26  1.6|
      Inflammation, Suppurative            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                   X                                                      |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epidermis, Hyperkeratosis            |                                     4                                    |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 3                       3                                                |      3  2.7|
      Cranium, Inflammation, Chronic Active|                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 2                 1     1                                      1         |      6  1.2|
      Alveolar Epithelium, Hyperplasia     |          2                       3                                       |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|     44  1.0|
      Interstitium, Mineralization         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |                X           X           X           X                     |      7     |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  34                                                               
NTP Experiment-Test: 89002-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 11:09:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1000 PPM                               | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                3           2  1     1  3     2     3        1  2     2  2|     21  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                2                                      2                  |      4  2.3|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                2                                                         |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                3           2  2        3     3     3                     |     11  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                        2     2     1                     |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                    +  +                              |   3        |
      Lens, Cataract                       |                   4                    4  4                              |      3  4.0|
      Retina, Atrophy                      |                   4                    4  4                              |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 4                       2                                            2   |      3  2.7|
      Nephropathy, Chronic                 | 4  3     4  2  2  3  3  4  2  2  2  2  2  2  3  4  2  3  1  3  3  2  3  3|     49  2.6|
      Renal Tubule, Hyperplasia            |                                                                         2|      2  3.0|
      Renal Tubule, Pigmentation           |    4  2     1  1  1  1     1  2  1  2  2  1  1  1  1  1  1  1  1  1  1  1|     47  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  35                                                               
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