TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
Control vs Stop Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 009 1000 PPM
Include 010 1000 PPM
Page 1
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 2 2 2 1 2 2 2 1 1 1 |
Mixed Cell Focus | X X X X |
Pigmentation, Hemosiderin | 2 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 2 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 1 2 2 1 |
Hepatocyte, Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 2 |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | 3 |
Degeneration, Fatty | 3 2 1 1 2 |
Hyperplasia | 2 3 2 1 1 |
Hypertrophy | 1 |
Pigmentation | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Pars Distalis, Cyst | 2 2 3 2 2 1 2 2 2 1 1 1 1 2 2|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 1 3 1 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 2 2 3 3 2 |
Inflammation, Chronic Active | 1 3 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3|
Bilateral, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + + |
Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 4 4 4 3 3 4|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemosiderin | 1 1 2 1 1 1 1 2 2 1 1 2 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 1 1 |
Necrosis | 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia, Cystic | 1 3 3 4 2 2 3 2 2 2 2 2 3 4 2 2 2 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 3 2 3 3 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X |
Inflammation, Chronic Active | 1 2 2 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 1 |
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 1 1 2 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 2 2 |
Renal Tubule, Pigmentation | 1 1 3 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X X X X | 11 |
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X X X X X | 9 |
Inflammation, Chronic | 1 2 1 1 1 2 1 1 1 1 1 1 1 3 1 1 1| 31 1.3|
Mixed Cell Focus | X X X | 7 |
Pigmentation, Hemosiderin | | 1 2.0|
Thrombosis | 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 | 24 1.2|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 | 7 1.9|
Hepatocyte, Centrilobular, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Accessory Spleen | X | 1 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 2 | 10 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 2 | 3 2.3|
Epithelium, Ulcer | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 1 2 2 1 1 1 2 1 1| 27 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Atrophy | | 1 3.0|
Degeneration, Fatty | 1 1 2 1 | 9 1.6|
Hyperplasia | 1 2 | 7 1.7|
Hypertrophy | | 1 1.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
Pars Distalis, Cyst | 2 3 2 1 2 1 1 1 2 2 2 2 2 3 3 2 2 2 2 2| 35 1.9|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 | 24 2.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1| 16 1.1|
Follicular Cell, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 | 10 2.6|
Inflammation, Chronic Active | 1 1| 4 1.5|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 3 3.0|
Bilateral, Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 | 11 3.7|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 35 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 1 2 2 1 2 1 1 1 1 2 2 2 1 1| 30 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 3 1 1 1 | 9 1.3|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 4.0|
Hyperplasia, Cystic | 2 2 2 2 4 2 1 2 3 2 2 2 2 1 2 2 2 3 3 3 2 1 2| 43 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 12 1.0|
Alveolar Epithelium, Hyperplasia | | 5 2.4|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 41 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X | 6 |
Inflammation, Chronic Active | 2 1 3 2 1 2 2 | 13 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 1 1 1 2 | 9 1.8|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 2 | 10 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Atrophy | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1| 44 1.3|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1| 48 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|
| 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Mixed Cell Focus | X X |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1|
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 3 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 2 |
Kupffer Cell, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Acinus, Atrophy | 2 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 1 2 1 2 2 2 1 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|
| 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Degeneration, Fatty | 1 2 1 1 4 2 |
Hyperplasia | 1 2 2 1 2|
Hypertrophy | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M + + + + + M + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 2 3 4 1 2 3 2 3|
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 3 3 2 3|
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Ectopic Tissue | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 2|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 4 4 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 2 1 2 1 2 2 1 1 1 1 1 1 |
Renal, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|
| 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 1 2 2 2 2 4 4 3 2 2 4 4 1 3 2 2 2 1 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + M + + + + + + + + +|
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X |
Inflammation, Chronic Active | 2 1 1 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 1 |
Respiratory Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Anterior Chamber, Cornea, | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4|
| 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Nephropathy, Chronic | 1 1 1 1 1 2 1 1 3 1 2 2 3 1 1 1 1 1 1 1 1 2 1 2 1|
Papilla, Necrosis | 4 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 1 1 1 2 1 2 1 1 1 1 1 2 1 1 2 3 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| |
| 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X X X X X X X X X| 16 |
Eosinophilic Focus | X X | 2 |
Hepatodiaphragmatic Nodule | X X X X X | 10 |
Inflammation, Chronic | 1 1 1 1 2 1 2 1 2 2 1 1 1 1 3 2 2 1 2| 36 1.3|
Mixed Cell Focus | X X X | 5 |
Pigmentation, Hemosiderin | 3 | 2 2.5|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1| 18 1.1|
Hepatocyte, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 1 | 9 1.4|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 2 2.5|
Kupffer Cell, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Pharyngeal, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Acinus, Atrophy | 1 1 1 4 2 1 1 1| 13 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 4 2 | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| |
| 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 2 2 1 1 2 2 2 2 2 1 1 1 1 | 25 1.6|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 2 2.5|
Degeneration, Fatty | 1 1 2 1 3 2 2 2 | 14 1.8|
Hyperplasia | 2 1 1 2 2 2 1 1 1 3 2 2 | 17 1.6|
Hypertrophy | 3 2 | 3 2.3|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2| 4 1.3|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 45 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 2 3 2 1 2 2 1 2 2 1 2 1| 24 2.1|
Pars Distalis, Hyperplasia | 2 2 2 2 3 3 2 2 2 2 1 3 2| 24 2.3|
Pars Intermedia, Cyst | 3 3 | 2 3.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
Pars Nervosa, Ectopic Tissue | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 2 2 | 17 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 2 | 10 2.2|
Inflammation, Chronic Active | 1 | 3 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 4 2 | 6 2.8|
Bilateral, Cyst | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| |
| 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 4 4 4 3 4 | 16 3.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 30 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 2 1 2 1 1 1 2 1 1| 26 1.3|
Renal, Ectasia | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 2 2 2 2 1 2 2 2 2 2 1 1 1 2 2 2 2 2 2 1 2| 45 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Osteopetrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 | 15 1.1|
Alveolar Epithelium, Hyperplasia | 2 2 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1| 46 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| |
| 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | | 2 |
Inflammation, Chronic Active | 2 1 1 | 7 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 1 2 1 1 | 10 1.3|
Respiratory Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | | 1 4.0|
Anterior Chamber, Cornea, | | |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Nephropathy, Chronic | 1 2 1 3 1 1 1 3 1 1 1 2 1 2 1 1 1 2 1 2 1 2 1 1| 49 1.4|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 49 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X|
Eosinophilic Focus | X |
Inflammation, Chronic | 2 1 1 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 3 1 1 3 2 1 2 1 2 3 1 3 1 2 2 1 3 3 1 2 1 2 1|
Hepatocyte, Degeneration, Cystic | 2 1 3 2 2 2 1 1 3 |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 1 |
Hepatocyte, Centrilobular, Necrosis | 4 |
Kupffer Cell, Hypertrophy | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 2 1 1 1 1 1 3 |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 3 3 2 |
Epithelium, Hyperplasia | 2 3 2 2 2 |
Epithelium, Ulcer | 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
Epithelium, Erosion | 2 |
Epithelium, Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
Pulmonary Artery, Thrombosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrium, Thrombosis | 4 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 1 1 2 1 1 1 1 1 2 1 3 1 1 |
Hyperplasia | 1 2 1 2 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 3 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | 3 2 2 1 2 |
Pars Distalis, Hyperplasia | 2 3 3 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 1 2 2 2 |
Follicular Cell, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Inflammation, Chronic Active | 4 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 3|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2|
Duct, Cyst | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 4 1 2 2 1 2 2 2 1 4 1 2 3 2 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Arteriole, Inflammation, Chronic | |
Germinal Epithelium, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 3 4 4 3 4 4 4 4 4 4 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 3 1 2 2 2 3 2 3 2 1 2 2 2 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 3 |
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X X X X X X X X X X|
Inflammation, Chronic Active | 2 3 2 2 2 2 2 1 2 3 4 3|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 |
Respiratory Epithelium, Hyperplasia | 3 2 2 2 2 2 1 2 3 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 2 2 2 4 2 3 1 2 2 4 3 3 3 3 2 3 4 4 2 4 3 2 4 2 3|
Renal Tubule, Hyperplasia | 3 |
Renal Tubule, Pigmentation | 1 1 3 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 2.0|
Basophilic Focus | X X X X X X X X | 17 |
Clear Cell Focus | X X X X | 6 |
Eosinophilic Focus | X | 2 |
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 | 22 1.2|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 2 3 3 2 2 1 3 2 2 2 1 2 2 2 3 3 2 3 1 1 1 3 2 2| 49 1.9|
Hepatocyte, Degeneration, Cystic | 2 1 2 2 1 1 2 | 16 1.8|
Hepatocyte, Necrosis | 2 2 | 3 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 2 1 2 | 10 1.4|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 2 2.0|
Hepatocyte, Centrilobular, Necrosis | 2 | 2 3.0|
Kupffer Cell, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + +| 15 |
Fat, Necrosis | 4 4 4 4 4 4 4 4 4| 12 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 1 2 1 1 1 | 12 1.3|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 1 3 3 | 10 2.6|
Epithelium, Hyperplasia | 2 1 3 | 8 2.1|
Epithelium, Ulcer | 4 4 1 4 4 | 8 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Epithelium, Erosion | 2| 2 2.0|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 3.0|
Pulmonary Artery, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 1 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 1 2 | 42 2.0|
Atrium, Thrombosis | 3 2 4 3 | 7 2.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 1 3 1 1 2 1 2 1 2 1 1 2 2 1 2| 28 1.4|
Hyperplasia | 2 2 1 1 1 1 1 | 13 1.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 2 1 1 1 1 2 2 | 18 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 47 |
Hyperplasia | 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Craniopharyngeal Duct, Cyst | 1 | 1 1.0|
Pars Distalis, Cyst | 2 1 | 7 1.9|
Pars Distalis, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 2 | 22 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 1 1 2 1 2| 16 1.6|
Follicular Cell, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 | 7 2.4|
Inflammation, Chronic Active | 2 2 1 2 2 2 3 1 2 2 1 3 2 2 2 2 2 2 2 2 2 | 42 1.9|
Duct, Cyst | 4 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 1 2 1 2 2 1 2 2 1 2 1 2 2 2 2 1| 38 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
Germinal Epithelium, Atrophy | 2 | 2 3.0|
Interstitial Cell, Hyperplasia | 2 2 1| 10 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 4 4 4 4 3 4 3 4 3 4 3 4 4| 30 3.8|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 34 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 1 1 1 2 1 1 1 1 2 1 1 1| 25 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 1 2| 5 2.0|
Hematopoietic Cell Proliferation | 2 2 | 4 2.8|
Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 2 3 2 3 3 2 2 1 2 1 2 3 2 3 2 2 2| 36 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia | | 1 3.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 2 4| 4 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic Active | 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X X X X X X X X | 21 |
Inflammation, Chronic Active | 2 2 2 2 4 2 2 4 2 2 3 3 2| 25 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 | 6 1.7|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 3 3 2 3 2 3 3 1| 24 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 3 2| 12 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Nephropathy, Chronic | 1 4 2 2 3 2 2 3 1 2 3 1 2 3 2 2 1 2 2 4 1 1 3 2 2| 50 2.4|
Renal Tubule, Hyperplasia | | 1 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| 49 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|
| 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 1 2 1 2 1 2 1 1 1 1 1 1 2 1 1 2 2 1|
Mixed Cell Focus | X X |
Pigmentation, Bile | |
Bile Duct, Hyperplasia | 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 1 2 2 1 1|
Hepatocyte, Degeneration, Cystic | 1 1 1 1 1 1 2 1 1 2 2 1 1|
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 4 |
Hepatocyte, Centrilobular, | |
Hypertrophy | |
Hepatocyte, Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Fat, Necrosis | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 1 1 2 1 1 2 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|
| 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 1 2 1 |
Epithelium, Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | |
Epithelium, Erosion | 2 |
Epithelium, Ulcer | 4 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2|
Mineralization | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Degeneration, Cystic | |
Degeneration, Fatty | 1 1 1 1 1 2 2 2 1 1 2 2 2 2 1 1|
Hyperplasia | 1 2 2 2 2 2 1 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 3 2 4 2 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + M +|
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | 2|
Pars Distalis, Cyst | 2 2 1 |
Pars Distalis, Hyperplasia | 2 2 3 2 1 2 1 1 2 3 2 2 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 2 1 1 2 2 2 1 |
Follicular Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|
| 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 |
Inflammation, Chronic Active | 2 3 2 2 2 1 2 2 3 2 4 2 2 2 2 2 2 3 1 1 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 1 2 2 2 2 2 2 1 1 1 2 2 2 1 2 2 3 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | |
Arteriole, Necrosis, Fibrinoid | |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 4 4 4 2 3 4 3 3 3 3 3 4 2 4 4|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Inguinal, Inflammation, Suppurative | |
Mediastinal, Ectasia | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Inflammation, | |
Granulomatous | |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 2 1 1 2 1 4 2 1 1|
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 |
Erythrophagocytosis | |
Hyperplasia, Lymphoid | 4 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 1 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia, Cystic | 2 1 1 2 2 1 2 1 1 2 2 2 2 2 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|
| 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | 2 |
Epidermis, Hyperkeratosis | 4 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Cranium, Inflammation, Chronic Active| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Interstitium, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X |
Inflammation, Chronic Active | 2 1 2 1 1 1 1 3 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Hyperplasia | 2 3 1 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 2 3 2 2 3 2 2 4 3 3 3 2 2 1 2 2 3 3 2 2 3 3 4 1 2|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7|
| 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| |
| 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | X X X| 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X X X X | 9 |
Eosinophilic Focus | X X X X| 7 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic | 2 1 1 2 1 1 1 1 1 2 1 1 1 1 1 | 34 1.3|
Mixed Cell Focus | X X X | 5 |
Pigmentation, Bile | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 2 2 2 2 1 2 1 2 3 2 2 3 3 1 1 2 2 3 2 1| 46 1.9|
Hepatocyte, Degeneration, Cystic | 3 1 2 2 2 2 2 1 2 1 1 3 1 1 2| 28 1.5|
Hepatocyte, Necrosis | 4 | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 3 1 1 2 2 2| 13 1.5|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 2 3.5|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 3 | 1 3.0|
Hepatocyte, Centrilobular, Necrosis | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 15 |
Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 4 4 4 4 | 11 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| |
| 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 2 1 2 1 | 19 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 2.0|
Epithelium, Hyperplasia | 1 | 4 1.3|
Epithelium, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 2 2 | 2 2.0|
Epithelium, Erosion | | 1 2.0|
Epithelium, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 2 2.0|
Degeneration, Cystic | 1 | 1 1.0|
Degeneration, Fatty | 1 2 1 2 2 2 1 1 1 | 25 1.4|
Hyperplasia | 2 2 2 2 1 2 1 1 2 | 17 1.7|
Hypertrophy | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 2 2 2 1 2 2 2 1 1 1 | 28 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Hyperplasia | 3 2 2 3 | 7 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Craniopharyngeal Duct, Cyst | | 1 2.0|
Pars Distalis, Cyst | 1 1 2 | 6 1.5|
Pars Distalis, Hyperplasia | 2 2 2 1 1 2 2 2 2 2 2| 26 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| |
| 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 2 1 2 1 1 1 1| 17 1.6|
Follicular Cell, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 2 2 2 2| 8 2.3|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 2 2 1 2 2 2 2 2 4 2 2 2| 44 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2 1 2 2 1 2 3 1 1 2 2 2 2| 37 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
Arteriole, Necrosis, Fibrinoid | 2 | 1 2.0|
Germinal Epithelium, Atrophy | 4 4 2 4 | 4 3.5|
Interstitial Cell, Hyperplasia | 1 1 1 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 3 4 4 4 4 3 3 3 4 4 3 4 4 3 3 4 4| 38 3.5|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 28 |
Inguinal, Inflammation, Suppurative | 3 | 1 3.0|
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Mediastinal, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 1 1 1 1 3 1 1 1 1 1 1 1 2 | 24 1.4|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| |
| 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 3 | 6 2.8|
Erythrophagocytosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 2 | 3 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 3 | 6 2.3|
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 2 4.0|
Hyperplasia, Cystic | 3 1 1 2 1 2 2 2 1 1 2| 26 1.6|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
Inflammation, Chronic Active | | 1 2.0|
Epidermis, Hyperkeratosis | 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 3 | 3 2.7|
Cranium, Inflammation, Chronic Active| 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 1 | 6 1.2|
Alveolar Epithelium, Hyperplasia | 2 3 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Interstitium, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:09:53
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| |
| 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 2 1 1 3 2 3 1 2 2 2| 21 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 4 2.3|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 3 2 2 3 3 3 | 11 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Lens, Cataract | 4 4 4 | 3 4.0|
Retina, Atrophy | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 2 | 3 2.7|
Nephropathy, Chronic | 4 3 4 2 2 3 3 4 2 2 2 2 2 2 3 4 2 3 1 3 3 2 3 3| 49 2.6|
Renal Tubule, Hyperplasia | 2| 2 3.0|
Renal Tubule, Pigmentation | 4 2 1 1 1 1 1 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1| 47 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------