National Toxicology Program

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TDMS Study 89002-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Degeneration Fatty
                                       Hypertrophy
Adrenal Medulla                        Hyperplasia
Bone Marrow                            Hyperplasia
Heart                                  Cardiomyopathy Chronic
Heart: Atrium                          Thrombosis
Kidney                                 Mineralization
                                       Nephropathy Chronic
Kidney: Renal Tubule                   Pigmentation
Liver                                  Basophilic Focus
                                       Clear Cell Focus
                                       Eosinophilic Focus
                                       Hepatodiaphragmatic Nodule
                                       Inflammation Chronic
                                       Mixed Cell Focus
Liver: Artery                          Inflammation Chronic
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Hypertrophy
Liver: Hepatocyte                      Degeneration Cystic
                                       Vacuolization Cytoplasmic
Liver: Hepatocyte, Centrilobular       Hypertrophy
Lung                                   Inflammation Chronic
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lymph Node, Mediastinal                Pigmentation Hemosiderin
Lymph Node, Mesenteric                 Ectasia
                                       Hyperplasia Lymphoid
Mammary Gland                          Hyperplasia Cystic
Mesentery: Fat                         Necrosis
Nose                                   Fungus
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Hyperplasia
                                       Metaplasia
Pancreas: Acinus                       Atrophy
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Hyperplasia
Preputial Gland                        Hyperplasia
                                       Inflammation Chronic
Prostate                               Inflammation Chronic
Skin: Epidermis                        Hyperkeratosis
Spleen                                 Fibrosis
                                       Hematopoietic Cell Proliferation
Stomach, Forestomach                   Inflammation Chronic
Stomach, Forestomach: Epithelium       Hyperplasia
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       

                                       Ulcer
Testes: Interstitial Cell              Hyperplasia
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Degeneration Cystic
                                       Degeneration Fatty
                                       Hyperplasia
                                       Hypertrophy
Bone                                   Osteopetrosis
Bone Marrow                            Hyperplasia
Brain                                  Hemorrhage
Clitoral Gland                         Inflammation Chronic
Eye: Lens                              Cataract
Eye: Retina                            Atrophy
Heart                                  Cardiomyopathy Chronic
Intestine Large, Colon                 Parasite Metazoan
Intestine Large, Rectum                Parasite Metazoan
Kidney                                 Mineralization
                                       Nephropathy Chronic
Kidney: Renal Tubule                   Pigmentation
Liver                                  Basophilic Focus
                                       Clear Cell Focus
Liver: Centrilobular                   Hypertrophy
Liver: Hepatocyte                      Necrosis
                                       Vacuolization Cytoplasmic
Liver: Hepatocyte, Centrilobular       Hypertrophy
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lymph Node, Mediastinal                Pigmentation Hemosiderin
Mammary Gland                          Cyst
                                       Hyperplasia Cystic
Nose                                   Fungus
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Hyperplasia
                                       Metaplasia
Pituitary Gland: Pars Distalis         Cyst
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             4.6%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              736 (T)          736 (T)          565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.126          (e)              P=0.612          P=0.463          P=0.273                          |
|POLY 3             |        P=0.078          (e)              P=0.503          P=0.273          P=0.266                          |
|POLY 1.5           |        P=0.068          (e)              P=0.496          P=0.249          P=0.251                          |
|POLY 6             |        P=0.100          (e)              P=0.508          P=0.301          P=0.291                          |
|LOGISTIC REGRESSION|        P=0.072          (e)              P=0.612          P=0.463          P=0.242                          |
|COCH-ARM / FISHERS |        P=0.069          (e)              P=0.455          P=0.204          P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             4.7%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        2/33 (6%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          738 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.115N         P=0.558          P=0.461N         P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.098N         P=0.513          P=0.492N         P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.101N         P=0.495          P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.098N         P=0.529          P=0.485N         P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.115N         P=0.558          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.117N         P=0.431          P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             2.8%             2.6%             0.0%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        736 (T)          736 (T)          624              ---              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.343N         P=0.698N         P=0.704N         P=0.311N         P=0.571N                         |
|POLY 3             |        P=0.459N         P=0.753          P=0.755N         P=0.471N         P=0.737N                         |
|POLY 1.5           |        P=0.477N         P=0.751          P=0.758          P=0.490N         P=0.750N                         |
|POLY 6             |        P=0.440N         P=0.753          P=0.748N         P=0.449N         P=0.715N                         |
|LOGISTIC REGRESSION|        P=0.453N         P=0.698N         P=0.763          (e)              P=0.571N                         |
|COCH-ARM / FISHERS |        P=0.512N         P=0.705          P=0.705          P=0.545N         P=0.752N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        4/50 (8%)        3/50 (6%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             9.3%             7.0%             0.0%             4.6%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        4/33 (12%)       3/34 (9%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          738 (T)          ---              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.537          P=0.085          P=0.157          (e)              P=0.250                          |
|POLY 3             |        P=0.510N         P=0.065          P=0.126          (e)              P=0.247                          |
|POLY 1.5           |        P=0.524N         P=0.058          P=0.118          (e)              P=0.241                          |
|POLY 6             |        P=0.505N         P=0.072          P=0.133          (e)              P=0.253                          |
|LOGISTIC REGRESSION|        P=0.565          P=0.085          P=0.157          (e)              P=0.241                          |
|COCH-ARM / FISHERS |        P=0.575N         P=0.040 *        P=0.091          (e)              P=0.248                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        28/60 (47%)      19/50 (38%)      16/50 (32%)      20/50 (40%)      25/60 (42%)                      |
|POLY-3 ADJUSTED (b)|        63.0%            46.9%            38.1%            43.5%            53.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        8/12 (67%)       6/16 (38%)       6/21 (29%)       12/31 (39%)      12/27 (44%)                      |
|FIRST INCIDENCE    |        396              507              443              518              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.020N*        P=0.064N         P=0.005N**       P<0.001N**       P=0.017N*                        |
|POLY 3             |        P=0.316N         P=0.089N         P=0.013N*        P=0.043N*        P=0.246N                         |
|POLY 1.5           |        P=0.391N         P=0.093N         P=0.017N*        P=0.077N         P=0.301N                         |
|POLY 6             |        P=0.211N         P=0.099N         P=0.012N*        P=0.024N*        P=0.166N                         |
|LOGISTIC REGRESSION|        P=0.342N         P=0.096N         P=0.024N*        P=0.071N         P=0.259N                         |
|COCH-ARM / FISHERS |        P=0.418N         P=0.236N         P=0.085N         P=0.306N         P=0.357N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/60 (15%)       11/50 (22%)      17/50 (34%)      15/50 (30%)      14/60 (23%)                      |
|POLY-3 ADJUSTED (b)|        21.1%            25.5%            37.7%            35.6%            32.1%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/28 (14%)       10/33 (30%)      10/34 (29%)      11/28 (39%)      8/28 (29%)                       |
|FIRST INCIDENCE    |        585              620              451              586              647                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.103          P=0.545          P=0.139          P=0.122          P=0.219                          |
|POLY 3             |        P=0.128          P=0.414          P=0.070          P=0.105          P=0.180                          |
|POLY 1.5           |        P=0.130          P=0.377          P=0.053          P=0.099          P=0.171                          |
|POLY 6             |        P=0.124          P=0.441          P=0.084          P=0.095          P=0.189                          |
|LOGISTIC REGRESSION|        P=0.131          P=0.440          P=0.053          P=0.106          P=0.197                          |
|COCH-ARM / FISHERS |        P=0.165          P=0.242          P=0.017 *        P=0.048 *        P=0.177                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/60 (22%)      11/50 (22%)      13/50 (26%)      15/50 (30%)      17/60 (28%)                      |
|POLY-3 ADJUSTED (b)|        32.0%            29.3%            33.1%            34.0%            39.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       7/16 (44%)       8/21 (38%)       12/31 (39%)      13/27 (48%)                      |
|FIRST INCIDENCE    |        564              524              605              619              460                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.218N         P=0.313N         P=0.291N         P=0.088N         P=0.280N                         |
|POLY 3             |        P=0.217          P=0.493N         P=0.557          P=0.516          P=0.328                          |
|POLY 1.5           |        P=0.172          P=0.483N         P=0.542          P=0.435          P=0.290                          |
|POLY 6             |        P=0.305          P=0.541N         P=0.544          P=0.590          P=0.389                          |
|LOGISTIC REGRESSION|        P=0.299          P=0.460N         P=0.575N         P=0.590N         P=0.362                          |
|COCH-ARM / FISHERS |        P=0.162          P=0.574          P=0.378          P=0.218          P=0.264                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       12/50 (24%)      23/50 (46%)      12/50 (24%)      17/60 (28%)                      |
|POLY-3 ADJUSTED (b)|        16.9%            28.0%            51.6%            29.1%            39.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/28 (21%)       12/33 (36%)      19/34 (56%)      10/28 (36%)      14/28 (50%)                      |
|FIRST INCIDENCE    |        698              738 (T)          451              634              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.016 *        P=0.255          P=0.003 **       P=0.141          P=0.016 *                        |
|POLY 3             |        P=0.047 *        P=0.166          P<0.001 **       P=0.142          P=0.018 *                        |
|POLY 1.5           |        P=0.046 *        P=0.140          P<0.001 **       P=0.134          P=0.016 *                        |
|POLY 6             |        P=0.046 *        P=0.192          P<0.001 **       P=0.135          P=0.020 *                        |
|LOGISTIC REGRESSION|        P=0.033 *        P=0.255          P<0.001 **       P=0.120          P=0.021 *                        |
|COCH-ARM / FISHERS |        P=0.059          P=0.074          P<0.001 **       P=0.074          P=0.019 *                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        2/50 (4%)        4/50 (8%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             5.1%             9.2%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        4/31 (13%)       2/27 (7%)                        |
|FIRST INCIDENCE    |        ---              619              443              736 (T)          677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.136          P=0.489          P=0.244          P=0.238          P=0.253                          |
|POLY 3             |        P=0.068          P=0.494          P=0.248          P=0.082          P=0.139                          |
|POLY 1.5           |        P=0.057          P=0.491          P=0.237          P=0.068          P=0.129                          |
|POLY 6             |        P=0.092          P=0.496          P=0.259          P=0.103          P=0.160                          |
|LOGISTIC REGRESSION|        P=0.058          P=0.468          P=0.095          P=0.238          P=0.164                          |
|COCH-ARM / FISHERS |        P=0.057          P=0.455          P=0.204          P=0.040 *        P=0.122                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        6/50 (12%)       8/50 (16%)       7/50 (14%)       3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             14.0%            18.6%            17.2%            7.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        6/33 (18%)       8/34 (24%)       7/28 (25%)       3/28 (11%)                       |
|FIRST INCIDENCE    |        738 (T)          738 (T)          738 (T)          738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.338          P=0.085          P=0.033 *        P=0.029 *        P=0.304                          |
|POLY 3             |        P=0.428          P=0.061          P=0.018 *        P=0.027 *        P=0.317                          |
|POLY 1.5           |        P=0.418          P=0.053          P=0.015 *        P=0.026 *        P=0.309                          |
|POLY 6             |        P=0.434          P=0.070          P=0.020 *        P=0.025 *        P=0.324                          |
|LOGISTIC REGRESSION|        P=0.338          P=0.085          P=0.033 *        P=0.029 *        P=0.304                          |
|COCH-ARM / FISHERS |        P=0.433          P=0.033 *        P=0.007 **       P=0.016 *        P=0.309                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        18/60 (30%)      27/50 (54%)      22/50 (44%)      25/50 (50%)      28/60 (47%)                      |
|POLY-3 ADJUSTED (b)|        46.0%            65.0%            51.8%            53.9%            61.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/12 (50%)       9/16 (56%)       9/21 (43%)       17/31 (55%)      17/27 (63%)                      |
|FIRST INCIDENCE    |        647              563              521              544              460                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.145N         P=0.167          P=0.477N         P=0.118N         P=0.396N                         |
|POLY 3             |        P=0.268          P=0.054          P=0.376          P=0.301          P=0.111                          |
|POLY 1.5           |        P=0.161          P=0.037 *        P=0.282          P=0.165          P=0.062                          |
|POLY 6             |        P=0.467          P=0.088          P=0.491          P=0.495          P=0.235                          |
|LOGISTIC REGRESSION|        P=0.183          P=0.023 *        P=0.283          P=0.337          P=0.088                          |
|COCH-ARM / FISHERS |        P=0.105          P=0.009 **       P=0.093          P=0.026 *        P=0.045 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        7/50 (14%)       6/50 (12%)       7/50 (14%)       4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             16.0%            13.6%            16.3%            9.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       5/33 (15%)       4/34 (12%)       2/28 (7%)        2/28 (7%)                        |
|FIRST INCIDENCE    |        738 (T)          430              399              417              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.488          P=0.223          P=0.327          P=0.163          P=0.509                          |
|POLY 3             |        P=0.521N         P=0.181          P=0.274          P=0.172          P=0.533                          |
|POLY 1.5           |        P=0.539N         P=0.157          P=0.247          P=0.156          P=0.515                          |
|POLY 6             |        P=0.506N         P=0.206          P=0.297          P=0.180          P=0.552                          |
|LOGISTIC REGRESSION|        P=0.535          P=0.159          P=0.236          P=0.120          P=0.512                          |
|COCH-ARM / FISHERS |        P=0.545          P=0.097          P=0.163          P=0.097          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             0.0%             0.0%             2.3%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        715              ---              ---              736 (T)          684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.305          P=0.490N         P=0.462N         P=0.591N         P=0.670                          |
|POLY 3             |        P=0.191          P=0.508N         P=0.497N         P=0.726N         P=0.538                          |
|POLY 1.5           |        P=0.182          P=0.510N         P=0.504N         P=0.749N         P=0.518                          |
|POLY 6             |        P=0.210          P=0.510N         P=0.493N         P=0.699N         P=0.570                          |
|LOGISTIC REGRESSION|        P=0.240          P=0.504N         P=0.483N         P=0.666N         P=0.577                          |
|COCH-ARM / FISHERS |        P=0.191          P=0.545N         P=0.545N         P=0.705          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             0.0%             0.0%             0.0%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        715              ---              ---              ---              684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.126          P=0.490N         P=0.462N         P=0.396N         P=0.488                          |
|POLY 3             |        P=0.078          P=0.508N         P=0.497N         P=0.471N         P=0.345                          |
|POLY 1.5           |        P=0.075          P=0.510N         P=0.504N         P=0.490N         P=0.324                          |
|POLY 6             |        P=0.083          P=0.510N         P=0.493N         P=0.450N         P=0.382                          |
|LOGISTIC REGRESSION|        P=0.091          P=0.504N         P=0.483N         P=0.440N         P=0.384                          |
|COCH-ARM / FISHERS |        P=0.075          P=0.545N         P=0.545N         P=0.545N         P=0.309                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/59 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              614              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.431N         P=0.489          (e)              (e)              (e)                              |
|POLY 3             |        P=0.388N         P=0.495          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.398N         P=0.491          (e)              (e)              (e)                              |
|POLY 6             |        P=0.384N         P=0.496          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.452N         P=0.465          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.451N         P=0.455          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       1/50 (2%)        4/50 (8%)        2/50 (4%)        2/59 (3%)                        |
|POLY-3 ADJUSTED (b)|        14.4%            2.3%             9.3%             4.9%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       0/33 (0%)        4/34 (12%)       1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        698              698              738 (T)          634              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.156N         P=0.040N*        P=0.273N         P=0.154N         P=0.127N                         |
|POLY 3             |        P=0.169N         P=0.051N         P=0.349N         P=0.135N         P=0.128N                         |
|POLY 1.5           |        P=0.163N         P=0.058N         P=0.374N         P=0.142N         P=0.136N                         |
|POLY 6             |        P=0.179N         P=0.045N*        P=0.334N         P=0.138N         P=0.122N                         |
|LOGISTIC REGRESSION|        P=0.141N         P=0.048N*        P=0.312N         P=0.140N         P=0.123N                         |
|COCH-ARM / FISHERS |        P=0.143N         P=0.091N         P=0.491N         P=0.203N         P=0.142N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        30/60 (50%)      33/50 (66%)      36/50 (72%)      32/50 (64%)      38/60 (63%)                      |
|POLY-3 ADJUSTED (b)|        67.4%            74.9%            77.7%            67.1%            79.1%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       11/16 (69%)      16/21 (76%)      19/31 (61%)      21/27 (78%)                      |
|FIRST INCIDENCE    |        396              435              360              518              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.048N*        P=0.477          P=0.505N         P=0.019N*        P=0.181N                         |
|POLY 3             |        P=0.242          P=0.281          P=0.180          P=0.579N         P=0.138                          |
|POLY 1.5           |        P=0.169          P=0.244          P=0.124          P=0.452          P=0.098                          |
|POLY 6             |        P=0.356          P=0.279          P=0.207          P=0.475N         P=0.199                          |
|LOGISTIC REGRESSION|        P=0.193          P=0.221          P=0.101          P=0.523          P=0.125                          |
|COCH-ARM / FISHERS |        P=0.155          P=0.067          P=0.015 *        P=0.100          P=0.099                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        11/60 (18%)      14/50 (28%)      17/50 (34%)      21/50 (42%)      16/59 (27%)                      |
|POLY-3 ADJUSTED (b)|        25.2%            31.4%            38.2%            45.1%            34.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       6/33 (18%)       12/34 (35%)      9/28 (32%)       2/28 (7%)                        |
|FIRST INCIDENCE    |        475              535              535              444              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.114          P=0.474          P=0.273          P=0.046 *        P=0.263                          |
|POLY 3             |        P=0.149          P=0.342          P=0.137          P=0.036 *        P=0.236                          |
|POLY 1.5           |        P=0.123          P=0.298          P=0.117          P=0.026 *        P=0.200                          |
|POLY 6             |        P=0.180          P=0.383          P=0.146          P=0.043 *        P=0.279                          |
|LOGISTIC REGRESSION|        P=0.110          P=0.279          P=0.123          P=0.010 *        P=0.179                          |
|COCH-ARM / FISHERS |        P=0.126          P=0.164          P=0.049 *        P=0.006 **       P=0.178                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             5.5%             0.0%             2.3%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        684              698              ---              708              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.340N         P=0.516          P=0.500N         P=0.645N         P=0.672N                         |
|POLY 3             |        P=0.442N         P=0.486          P=0.498N         P=0.726N         P=0.738N                         |
|POLY 1.5           |        P=0.459N         P=0.483          P=0.504N         P=0.749N         P=0.750N                         |
|POLY 6             |        P=0.420N         P=0.485          P=0.494N         P=0.699N         P=0.717N                         |
|LOGISTIC REGRESSION|        P=0.430N         P=0.486          P=0.499N         P=0.739N         P=0.735N                         |
|COCH-ARM / FISHERS |        P=0.489N         P=0.431          P=0.545N         P=0.705          P=0.752N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/59 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        705              698              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.166N         P=0.722N         P=0.470N         P=0.513N         P=0.488N                         |
|POLY 3             |        P=0.156N         P=0.752N         P=0.492N         P=0.503N         P=0.498N                         |
|POLY 1.5           |        P=0.156N         P=0.758          P=0.501N         P=0.506N         P=0.502N                         |
|POLY 6             |        P=0.159N         P=0.741N         P=0.486N         P=0.506N         P=0.494N                         |
|LOGISTIC REGRESSION|        P=0.163N         P=0.764N         P=0.496N         P=0.505N         P=0.497N                         |
|COCH-ARM / FISHERS |        P=0.168N         P=0.705          P=0.545N         P=0.545N         P=0.504N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/60 (7%)        0/50 (0%)        6/50 (12%)       2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        10.2%            0.0%             14.7%            4.5%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        564              ---              527              518              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.141N         P=0.080N         P=0.388          P=0.235N         P=0.112N                         |
|POLY 3             |        P=0.177N         P=0.069N         P=0.395          P=0.281N         P=0.157N                         |
|POLY 1.5           |        P=0.206N         P=0.068N         P=0.367          P=0.318N         P=0.169N                         |
|POLY 6             |        P=0.137N         P=0.073N         P=0.419          P=0.246N         P=0.141N                         |
|LOGISTIC REGRESSION|        P=0.222N         P=0.079N         P=0.248          P=0.439N         P=0.167N                         |
|COCH-ARM / FISHERS |        P=0.219N         P=0.084N         P=0.262          P=0.430N         P=0.182N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             4.7%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              392              ---              444              652                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.264          P=0.496          (e)              P=0.237          P=0.520                          |
|POLY 3             |        P=0.261          P=0.511          (e)              P=0.242          P=0.508                          |
|POLY 1.5           |        P=0.257          P=0.500          (e)              P=0.235          P=0.503                          |
|POLY 6             |        P=0.267          P=0.521          (e)              P=0.243          P=0.514                          |
|LOGISTIC REGRESSION|        P=0.335          P=0.268          (e)              P=0.048 *        P=0.502                          |
|COCH-ARM / FISHERS |        P=0.276          P=0.455          (e)              P=0.204          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      12/50 (24%)      14/48 (29%)      11/50 (22%)      10/59 (17%)                      |
|POLY-3 ADJUSTED (b)|        23.6%            27.4%            33.5%            25.7%            23.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/28 (21%)       10/33 (30%)      13/34 (38%)      6/28 (21%)       9/27 (33%)                       |
|FIRST INCIDENCE    |        523              535              600              586              703                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.523          P=0.554          P=0.410          P=0.487          P=0.587                          |
|POLY 3             |        P=0.467N         P=0.434          P=0.220          P=0.509          P=0.587                          |
|POLY 1.5           |        P=0.462N         P=0.387          P=0.191          P=0.480          P=0.578                          |
|POLY 6             |        P=0.485N         P=0.477          P=0.241          P=0.514          P=0.592                          |
|LOGISTIC REGRESSION|        P=0.461N         P=0.429          P=0.251          P=0.463          P=0.575N                         |
|COCH-ARM / FISHERS |        P=0.428N         P=0.236          P=0.094          P=0.320          P=0.580                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      11/50 (22%)      4/48 (8%)        5/50 (10%)       5/59 (8%)                        |
|POLY-3 ADJUSTED (b)|        20.6%            24.1%            9.3%             12.0%            11.4%                            |
|INT SACRIFICE 1 (c)|        6/10 (60%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)                       |
|TERMINAL (d)       |        1/28 (4%)        6/33 (18%)       2/34 (6%)        3/28 (11%)       2/27 (7%)                        |
|FIRST INCIDENCE    |        184 (I)          337              417              572              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.034N*        P=0.080          P=0.590N         P=0.502          P=0.116N                         |
|POLY 3             |        P=0.054N         P=0.437          P=0.111N         P=0.208N         P=0.179N                         |
|POLY 1.5           |        P=0.051N         P=0.401          P=0.121N         P=0.204N         P=0.177N                         |
|POLY 6             |        P=0.059N         P=0.478          P=0.104N         P=0.225N         P=0.179N                         |
|LOGISTIC REGRESSION|        P=0.026N*        P=0.055          P=0.557          P=0.564          P=0.112N                         |
|COCH-ARM / FISHERS |        P=0.039N*        P=0.320          P=0.161N         P=0.232N         P=0.142N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/2 (100%)       1/1 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|FIRST INCIDENCE    |        715              736 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             5.4%             0.0%             0.0%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              507              ---              ---              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.590N         P=0.229          (e)              (e)              P=0.662                          |
|POLY 3             |        P=0.594N         P=0.233          (e)              (e)              P=0.521                          |
|POLY 1.5           |        P=0.611N         P=0.228          (e)              (e)              P=0.510                          |
|POLY 6             |        P=0.578N         P=0.235          (e)              (e)              P=0.539                          |
|LOGISTIC REGRESSION|        P=0.588          P=0.184          (e)              (e)              P=0.662                          |
|COCH-ARM / FISHERS |        P=0.586          P=0.204          (e)              (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/1 (0%)         0/4 (0%)         0/1 (0%)         0/3 (0%)         0/3 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         0/2 (0%)         0/1 (0%)         0/3 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/3 (67%)        0/3 (0%)         0/2 (0%)         0/2 (0%)         1/2 (50%)                        |
|POLY-3 ADJUSTED (b)|        70.3%            0.0%             0.0%             0.0%             50.0%                            |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        2/2 (100%)       0/2 (0%)         0/0 (0%)         0/1 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        738 (T)          ---              ---              ---              701                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.570N         P=0.193N         P=1.000N         P=0.362N         P=0.682N                         |
|POLY 3             |        P=0.612N         P=0.146N         P=0.485N         P=0.350N         P=0.657N                         |
|POLY 1.5           |        P=0.585N         P=0.152N         P=0.404N         P=0.318N         P=0.664N                         |
|POLY 6             |        P=0.639N         P=0.134N         P=0.572N         P=0.393N         P=0.644N                         |
|LOGISTIC REGRESSION|        P=0.601N         (e)              (e)              (e)              P=0.737N                         |
|COCH-ARM / FISHERS |        P=0.539N         P=0.200N         P=0.300N         P=0.300N         P=0.700N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/1 (100%)       3/4 (75%)        0/1 (0%)         3/3 (100%)       3/3 (100%)                       |
|POLY-3 ADJUSTED (b)|        100.0%           77.1%            0.0%             100.0%           100.0%                           |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         2/2 (100%)       0/1 (0%)         3/3 (100%)       1/1 (100%)                       |
|FIRST INCIDENCE    |        396              592              ---              736 (T)          677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.418          P=0.738          P=0.510N         (e)              (e)                              |
|POLY 3             |        P=0.313          P=0.783N         P=1.000          (e)              (e)                              |
|POLY 1.5           |        P=0.308          P=0.766N         P=1.000          (e)              (e)                              |
|POLY 6             |        P=0.324          P=0.817N         P=1.000          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.228          (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.325          P=0.800N         P=0.500N         (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/3 (0%)         2/3 (67%)        2/2 (100%)       2/2 (100%)       0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             70.3%            100.0%           100.0%           0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/2 (0%)         2/2 (100%)       0/0 (0%)         1/1 (100%)       0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              738 (T)          417              586              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.567          P=0.193          P=0.262          P=0.161          (e)                              |
|POLY 3             |        P=0.574          P=0.146          P<0.001 **       P<0.001 **       (e)                              |
|POLY 1.5           |        P=0.592          P=0.152          P<0.001 **       P<0.001 **       (e)                              |
|POLY 6             |        P=0.535          P=0.134          P<0.001 **       P<0.001 **       (e)                              |
|LOGISTIC REGRESSION|        P=0.630N         P=0.193          (e)              P=0.174          (e)                              |
|COCH-ARM / FISHERS |        P=0.567          P=0.200          P=0.100          P=0.100          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Synechia                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/1 (0%)         0/4 (0%)         0/1 (0%)         0/3 (0%)         0/3 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         0/2 (0%)         0/1 (0%)         0/3 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Synechia                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/3 (0%)         2/3 (67%)        0/2 (0%)         0/2 (0%)         0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             66.7%            0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/2 (0%)         1/2 (50%)        0/0 (0%)         0/1 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              698              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.363N         P=0.258          (e)              (e)              (e)                              |
|POLY 3             |        P=0.385N         P=0.172          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.358N         P=0.165          (e)              (e)              (e)                              |
|POLY 6             |        P=0.422N         P=0.185          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.389N         P=0.186          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.353N         P=0.200          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/1 (100%)       4/4 (100%)       0/1 (0%)         3/3 (100%)       3/3 (100%)                       |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           0.0%             100.0%           100.0%                           |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/0 (0%)         2/2 (100%)       0/1 (0%)         3/3 (100%)       1/1 (100%)                       |
|FIRST INCIDENCE    |        396              592              ---              736 (T)          677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.587          (e)              P=0.510N         (e)              (e)                              |
|POLY 3             |        P=1.000N         (e)              P=1.000          (e)              (e)                              |
|POLY 1.5           |        P=1.000N         (e)              P=1.000          (e)              (e)                              |
|POLY 6             |        P=1.000N         (e)              P=1.000          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.620          (e)              P=0.500N         (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/3 (0%)         3/3 (100%)       2/2 (100%)       2/2 (100%)       0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           100.0%           100.0%           0.0%                             |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        0/2 (0%)         2/2 (100%)       0/0 (0%)         1/1 (100%)       0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              698              417              586              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.514N         P=0.104          P=0.262          P=0.161          (e)                              |
|POLY 3             |        P=0.999N         P<0.001 **       P<0.001 **       P<0.001 **       (e)                              |
|POLY 1.5           |        P=1.000N         P<0.001 **       P<0.001 **       P<0.001 **       (e)                              |
|POLY 6             |        P=0.970N         P<0.001 **       P<0.001 **       P<0.001 **       (e)                              |
|LOGISTIC REGRESSION|        P=0.499N         P=0.051          (e)              P=0.174          (e)                              |
|COCH-ARM / FISHERS |        P=0.579N         P=0.050          P=0.100          P=0.100          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        50/60 (83%)      41/50 (82%)      41/50 (82%)      44/50 (88%)      55/60 (92%)                      |
|POLY-3 ADJUSTED (b)|        89.8%            87.0%            89.0%            89.3%            95.2%                            |
|INT SACRIFICE 1 (c)|        9/10 (90%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        12/12 (100%)     15/16 (94%)      21/21 (100%)     27/31 (87%)      26/27 (96%)                      |
|FIRST INCIDENCE    |        184 (I)          410              360              213              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.004N**       P=0.391N         P=0.094N         P<0.001N**       P=0.019N*                        |
|POLY 3             |        P=0.111          P=0.446N         P=0.595N         P=0.601N         P=0.199                          |
|POLY 1.5           |        P=0.087          P=0.442N         P=0.518N         P=0.555          P=0.170                          |
|POLY 6             |        P=0.181          P=0.504N         P=0.606          P=0.496N         P=0.266                          |
|LOGISTIC REGRESSION|        P=0.069          P=0.513N         P=0.427N         P=0.364          P=0.138                          |
|COCH-ARM / FISHERS |        P=0.065          P=0.525N         P=0.525N         P=0.340          P=0.135                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        29/60 (48%)      31/50 (62%)      36/50 (72%)      35/50 (70%)      26/60 (43%)                      |
|POLY-3 ADJUSTED (b)|        60.4%            66.8%            79.6%            77.2%            57.6%                            |
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        15/28 (54%)      22/33 (67%)      29/34 (85%)      22/28 (79%)      17/28 (61%)                      |
|FIRST INCIDENCE    |        184 (I)          284              535              459              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.437N         P=0.554          P=0.290          P=0.114          P=0.328N                         |
|POLY 3             |        P=0.500N         P=0.331          P=0.029 *        P=0.055          P=0.473N                         |
|POLY 1.5           |        P=0.434N         P=0.279          P=0.029 *        P=0.055          P=0.445N                         |
|POLY 6             |        P=0.475          P=0.371          P=0.024 *        P=0.042 *        P=0.509N                         |
|LOGISTIC REGRESSION|        P=0.284N         P=0.248          P=0.072          P=0.073          P=0.329N                         |
|COCH-ARM / FISHERS |        P=0.248N         P=0.107          P=0.010 *        P=0.017 *        P=0.357N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       7/50 (14%)       4/50 (8%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        18.5%            18.4%            10.4%            4.6%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/12 (25%)       1/16 (6%)        2/21 (10%)       1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        684              507              640              708              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.532N         P=0.109N         P=0.004N**       P=0.003N**                       |
|POLY 3             |        P=0.003N**       P=0.614N         P=0.245N         P=0.049N*        P=0.020N*                        |
|POLY 1.5           |        P=0.004N**       P=0.594          P=0.268N         P=0.067N         P=0.025N*                        |
|POLY 6             |        P=0.002N**       P=0.596N         P=0.226N         P=0.034N*        P=0.014N*                        |
|LOGISTIC REGRESSION|        P=0.002N**       P=0.578          P=0.210N         P=0.017N*        P=0.008N**                       |
|COCH-ARM / FISHERS |        P=0.006N**       P=0.466          P=0.378N         P=0.133N         P=0.031N*                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              620              ---              ---              668                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.408          P=0.514          (e)              (e)              P=0.527                          |
|POLY 3             |        P=0.433          P=0.509          (e)              (e)              P=0.508                          |
|POLY 1.5           |        P=0.426          P=0.498          (e)              (e)              P=0.503                          |
|POLY 6             |        P=0.438          P=0.520          (e)              (e)              P=0.513                          |
|LOGISTIC REGRESSION|        P=0.413          P=0.451          (e)              (e)              P=0.503                          |
|COCH-ARM / FISHERS |        P=0.413          P=0.455          (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        3/50 (6%)        1/50 (2%)        3/49 (6%)        3/59 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             7.9%             2.6%             7.0%             7.2%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        1/21 (5%)        1/30 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        736 (T)          410              736 (T)          708              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.454          P=0.330          P=0.633N         P=0.596          P=0.536                          |
|POLY 3             |        P=0.309          P=0.308          P=0.758N         P=0.354          P=0.342                          |
|POLY 1.5           |        P=0.280          P=0.297          P=0.757          P=0.317          P=0.319                          |
|POLY 6             |        P=0.363          P=0.317          P=0.752N         P=0.399          P=0.381                          |
|LOGISTIC REGRESSION|        P=0.267          P=0.194          P=0.633N         P=0.439          P=0.342                          |
|COCH-ARM / FISHERS |        P=0.262          P=0.244          P=0.705          P=0.237          P=0.303                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        1/50 (2%)        5/50 (10%)       1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             2.3%             12.3%            2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        2/33 (6%)        0/34 (0%)        5/28 (18%)       1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          417              738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.234          P=0.275          P=0.500          P=0.032 *        P=0.500                          |
|POLY 3             |        P=0.256          P=0.245          P=0.512          P=0.029 *        P=0.507                          |
|POLY 1.5           |        P=0.252          P=0.234          P=0.502          P=0.028 *        P=0.502                          |
|POLY 6             |        P=0.263          P=0.257          P=0.520          P=0.027 *        P=0.511                          |
|LOGISTIC REGRESSION|        P=0.269          P=0.275          P=0.250          P=0.032 *        P=0.500                          |
|COCH-ARM / FISHERS |        P=0.285          P=0.204          P=0.455          P=0.017 *        P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        5/50 (10%)       3/50 (6%)        3/49 (6%)        5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             13.1%            7.7%             7.0%             12.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        3/30 (10%)       5/27 (19%)                       |
|FIRST INCIDENCE    |        643              507              583              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.432          P=0.098          P=0.373          P=0.577          P=0.322                          |
|POLY 3             |        P=0.251          P=0.101          P=0.312          P=0.348          P=0.124                          |
|POLY 1.5           |        P=0.221          P=0.095          P=0.299          P=0.315          P=0.112                          |
|POLY 6             |        P=0.301          P=0.106          P=0.322          P=0.388          P=0.146                          |
|LOGISTIC REGRESSION|        P=0.212          P=0.062          P=0.295          P=0.392          P=0.178                          |
|COCH-ARM / FISHERS |        P=0.191          P=0.067          P=0.244          P=0.237          P=0.103                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        5/50 (10%)       8/50 (16%)       5/50 (10%)       4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             11.7%            18.3%            12.1%            9.2%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        5/33 (15%)       7/34 (21%)       2/28 (7%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        738 (T)          738 (T)          451              605              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.349          P=0.284          P=0.081          P=0.216          P=0.353                          |
|POLY 3             |        P=0.437          P=0.230          P=0.055          P=0.216          P=0.362                          |
|POLY 1.5           |        P=0.421          P=0.210          P=0.046 *        P=0.207          P=0.348                          |
|POLY 6             |        P=0.452          P=0.250          P=0.062          P=0.216          P=0.378                          |
|LOGISTIC REGRESSION|        P=0.400          P=0.284          P=0.052          P=0.206          P=0.348                          |
|COCH-ARM / FISHERS |        P=0.421          P=0.151          P=0.024 *        P=0.151          P=0.340                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        1/48 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             0.0%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       0/16 (0%)        0/21 (0%)        1/30 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        736 (T)          ---              ---              736 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.079N         P=0.175N         P=0.124N         P=0.200N         P=0.085N                         |
|POLY 3             |        P=0.204N         P=0.245N         P=0.233N         P=0.464N         P=0.214N                         |
|POLY 1.5           |        P=0.208N         P=0.248N         P=0.241N         P=0.497N         P=0.226N                         |
|POLY 6             |        P=0.195N         P=0.245N         P=0.227N         P=0.426N         P=0.195N                         |
|LOGISTIC REGRESSION|        P=0.079N         (e)              (e)              P=0.200N         (e)                              |
|COCH-ARM / FISHERS |        P=0.196N         P=0.295N         P=0.295N         P=0.584N         P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/49 (0%)        0/50 (0%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.5%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        1/28 (4%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.126          (e)              (e)              P=0.500          P=0.500                          |
|POLY 3             |        P=0.138          (e)              (e)              P=0.497          P=0.507                          |
|POLY 1.5           |        P=0.139          (e)              (e)              P=0.494          P=0.502                          |
|POLY 6             |        P=0.139          (e)              (e)              P=0.495          P=0.511                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.500          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.157          (e)              (e)              P=0.455          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        4/50 (8%)        1/50 (2%)        1/50 (2%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             10.8%            2.6%             2.3%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        1/21 (5%)        1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        681              507              736 (T)          736 (T)          684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.468N         P=0.198          P=0.704N         P=0.616N         P=0.508                          |
|POLY 3             |        P=0.525          P=0.171          P=0.759N         P=0.727N         P=0.343                          |
|POLY 1.5           |        P=0.492          P=0.166          P=0.757          P=0.749N         P=0.323                          |
|POLY 6             |        P=0.570          P=0.172          P=0.755N         P=0.701N         P=0.378                          |
|LOGISTIC REGRESSION|        P=0.498          P=0.158          P=0.751N         P=0.717N         P=0.375                          |
|COCH-ARM / FISHERS |        P=0.444          P=0.130          P=0.705          P=0.705          P=0.309                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.245N         P=0.467N         P=0.461N         P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.259N         P=0.493N         P=0.492N         P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.251N         P=0.503N         P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.271N         P=0.483N         P=0.485N         P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.245N         (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.247N         P=0.545N         P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/60 (13%)       0/50 (0%)        0/50 (0%)        0/50 (0%)        9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        17.6%            0.0%             0.0%             0.0%             17.8%                            |
|INT SACRIFICE 1 (c)|        8/10 (80%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         9/10 (90%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        184 (I)          ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.357          P=1.000          P=1.000          P=1.000          P=0.500                          |
|POLY 3             |        P=0.225          P=0.009N**       P=0.007N**       P=0.004N**       P=0.598                          |
|POLY 1.5           |        P=0.203          P=0.009N**       P=0.008N**       P=0.006N**       P=0.555                          |
|POLY 6             |        P=0.258          P=0.010N*        P=0.007N**       P=0.003N**       P=0.549N                         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.192          P=0.006N**       P=0.006N**       P=0.006N**       P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      1/50 (2%)        0/50 (0%)        0/50 (0%)        10/60 (17%)                      |
|POLY-3 ADJUSTED (b)|        19.6%            2.3%             0.0%             0.0%             19.0%                            |
|INT SACRIFICE 1 (c)|        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        184 (I)          650              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.451N         P=0.520          P=1.000          P=1.000          P=1.000                          |
|POLY 3             |        P=0.314          P=0.010N*        P=0.002N**       P=0.003N**       P=0.571N                         |
|POLY 1.5           |        P=0.324          P=0.011N*        P=0.002N**       P=0.003N**       P=0.588N                         |
|POLY 6             |        P=0.295          P=0.008N**       P=0.002N**       P=0.003N**       P=0.556N                         |
|LOGISTIC REGRESSION|        P=0.412N         P=0.479N         (e)              (e)              P=0.503N                         |
|COCH-ARM / FISHERS |        P=0.336          P=0.010N*        P=0.002N**       P=0.002N**       P=0.596N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        60/60 (100%)     49/50 (98%)      50/50 (100%)     49/50 (98%)      58/60 (97%)                      |
|POLY-3 ADJUSTED (b)|        100.0%           99.3%            100.0%           100.0%           99.9%                            |
|INT SACRIFICE 1 (c)|        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         9/10 (90%)                       |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     21/21 (100%)     31/31 (100%)     27/27 (100%)                     |
|FIRST INCIDENCE    |        184 (I)          410              360              518              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.359N         (e)              P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.910          P=0.977N         (e)              P=1.000N         P=1.000N                         |
|POLY 1.5           |        P=0.695N         P=0.747N         (e)              P=1.000N         P=0.995N                         |
|POLY 6             |        P=1.000          P=1.000N         (e)              P=1.000N         P=1.000N                         |
|LOGISTIC REGRESSION|        P=0.217N         P=0.386N         (e)              P=0.053N         P=0.234N                         |
|COCH-ARM / FISHERS |        P=0.124N         P=0.455N         (e)              P=0.455N         P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        47/60 (78%)      46/50 (92%)      44/50 (88%)      48/50 (96%)      52/60 (87%)                      |
|POLY-3 ADJUSTED (b)|        95.7%            96.2%            92.8%            97.9%            99.8%                            |
|INT SACRIFICE 1 (c)|        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)                       |
|TERMINAL (d)       |        28/28 (100%)     33/33 (100%)     34/34 (100%)     28/28 (100%)     28/28 (100%)                     |
|FIRST INCIDENCE    |        184 (I)          284              451              417              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.105          P=0.267N         P=0.126N         P=0.279          P=0.335                          |
|POLY 3             |        P=0.075          P=0.709          P=0.405N         P=0.475          P=0.111                          |
|POLY 1.5           |        P=0.038 *        P=0.381          P=0.617N         P=0.152          P=0.047 *                        |
|POLY 6             |        P=0.201          P=0.655N         P=0.267N         P=0.895          P=0.738                          |
|LOGISTIC REGRESSION|        P=0.029 *        P=0.479          P=0.357N         P=0.267          P=0.054                          |
|COCH-ARM / FISHERS |        P=0.142          P=0.042 *        P=0.139          P=0.006 **       P=0.168                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             0.0%             0.0%             0.0%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        695              ---              ---              ---              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.327          P=0.500N         P=0.484N         P=0.408N         P=0.687                          |
|POLY 3             |        P=0.228          P=0.509N         P=0.498N         P=0.471N         P=0.537                          |
|POLY 1.5           |        P=0.222          P=0.510N         P=0.504N         P=0.490N         P=0.518                          |
|POLY 6             |        P=0.239          P=0.510N         P=0.493N         P=0.451N         P=0.568                          |
|LOGISTIC REGRESSION|        P=0.262          P=0.508N         P=0.495N         P=0.474N         P=0.580                          |
|COCH-ARM / FISHERS |        P=0.225          P=0.545N         P=0.545N         P=0.545N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              719                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.140          (e)              (e)              (e)              P=0.513                          |
|POLY 3             |        P=0.151          (e)              (e)              (e)              P=0.507                          |
|POLY 1.5           |        P=0.152          (e)              (e)              (e)              P=0.503                          |
|POLY 6             |        P=0.151          (e)              (e)              (e)              P=0.512                          |
|LOGISTIC REGRESSION|        P=0.148          (e)              (e)              (e)              P=0.510                          |
|COCH-ARM / FISHERS |        P=0.160          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        49/60 (82%)      48/50 (96%)      49/50 (98%)      50/50 (100%)     57/60 (95%)                      |
|POLY-3 ADJUSTED (b)|        98.3%            98.4%            99.8%            100.0%           95.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     21/21 (100%)     31/31 (100%)     25/27 (93%)                      |
|FIRST INCIDENCE    |        396              410              443              213              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.008N**       P=0.353N         P=0.114N         P<0.001N**       P=0.064N                         |
|POLY 3             |        P=0.128N         P=0.860          P=0.670          P=0.603          P=0.355N                         |
|POLY 1.5           |        P=0.430N         P=0.568          P=0.241          P=0.122          P=0.617N                         |
|POLY 6             |        P=0.051N         P=0.953          P=0.898          P=0.891          P=0.286N                         |
|LOGISTIC REGRESSION|        P=0.003 **       P=0.679N         P=0.740          P=0.142          P=0.014 *                        |
|COCH-ARM / FISHERS |        P=0.006 **       P=0.019 *        P=0.005 **       P<0.001 **       P=0.022 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        48/60 (80%)      48/50 (96%)      50/50 (100%)     50/50 (100%)     59/60 (98%)                      |
|POLY-3 ADJUSTED (b)|        98.1%            99.6%            100.0%           100.0%           100.0%                           |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        28/28 (100%)     33/33 (100%)     34/34 (100%)     28/28 (100%)     28/28 (100%)                     |
|FIRST INCIDENCE    |        391              337              399              417              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.025 *        P=0.179N         P=0.246N         P=0.408          P=0.099                          |
|POLY 3             |        P=0.119          P=0.673          P=0.530          P=0.530          P=0.475                          |
|POLY 1.5           |        P=0.003 **       P=0.226          P=0.061          P=0.061          P=0.039 *                        |
|POLY 6             |        P=0.779          P=0.998          P=0.997          P=0.997          P=0.996                          |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.366          P=0.162          P=0.197          P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.011 *        P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             2.6%             2.3%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        647              ---              736 (T)          736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.542N         P=0.241N         P=0.422N         P=0.312N         P=0.481N                         |
|POLY 3             |        P=0.449          P=0.247N         P=0.498N         P=0.452N         P=0.660N                         |
|POLY 1.5           |        P=0.431          P=0.249N         P=0.508N         P=0.483N         P=0.678N                         |
|POLY 6             |        P=0.483          P=0.250N         P=0.493N         P=0.418N         P=0.630N                         |
|LOGISTIC REGRESSION|        P=0.541          P=0.248N         P=0.488N         P=0.444N         P=0.627N                         |
|COCH-ARM / FISHERS |        P=0.439          P=0.295N         P=0.569N         P=0.569N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              613              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.547          (e)              (e)              P=0.495          (e)                              |
|POLY 3             |        P=0.500          (e)              (e)              P=0.500          (e)                              |
|POLY 1.5           |        P=0.500          (e)              (e)              P=0.495          (e)                              |
|POLY 6             |        P=0.506          (e)              (e)              P=0.499          (e)                              |
|LOGISTIC REGRESSION|        P=0.552          (e)              (e)              P=0.447          (e)                              |
|COCH-ARM / FISHERS |        P=0.549          (e)              (e)              P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        18/60 (30%)      14/50 (28%)      20/50 (40%)      16/50 (32%)      32/60 (53%)                      |
|POLY-3 ADJUSTED (b)|        43.3%            37.9%            49.6%            36.2%            71.6%                            |
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        10/12 (83%)      12/16 (75%)      16/21 (76%)      14/31 (45%)      25/27 (93%)                      |
|FIRST INCIDENCE    |        184 (I)          563              360              544              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.468          P=0.091N         P=0.197N         P=0.002N**       P=0.520N                         |
|POLY 3             |        P=0.003 **       P=0.394N         P=0.355          P=0.322N         P=0.004 **                       |
|POLY 1.5           |        P=0.002 **       P=0.377N         P=0.335          P=0.417N         P=0.003 **                       |
|POLY 6             |        P=0.008 **       P=0.437N         P=0.354          P=0.218N         P=0.007 **                       |
|LOGISTIC REGRESSION|        P=0.006 **       P=0.315N         P=0.388          P=0.352N         P=0.011 *                        |
|COCH-ARM / FISHERS |        P=0.003 **       P=0.493N         P=0.185          P=0.492          P=0.008 **                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        45/60 (75%)      42/50 (84%)      44/50 (88%)      35/50 (70%)      34/60 (57%)                      |
|POLY-3 ADJUSTED (b)|        87.1%            92.9%            93.8%            79.0%            76.0%                            |
|INT SACRIFICE 1 (c)|        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        27/28 (96%)      33/33 (100%)     34/34 (100%)     25/28 (89%)      27/28 (96%)                      |
|FIRST INCIDENCE    |        184 (I)          522              399              417              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.018N*        P=0.220N         P=0.302N         P=0.186N         P=0.020N*                        |
|POLY 3             |        P=0.008N**       P=0.250          P=0.184          P=0.186N         P=0.103N                         |
|POLY 1.5           |        P=0.006N**       P=0.273          P=0.189          P=0.163N         P=0.073N                         |
|POLY 6             |        P=0.012N*        P=0.231          P=0.149          P=0.281N         P=0.130N                         |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.575N         P=0.394          P=0.074N         P=0.011N*                        |
|COCH-ARM / FISHERS |        P<0.001N**       P=0.179          P=0.068          P=0.354N         P=0.027N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       2/50 (4%)        7/50 (14%)       5/50 (10%)       9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        16.0%            5.5%             18.3%            11.5%            21.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/12 (50%)       2/16 (13%)       7/21 (33%)       5/31 (16%)       9/27 (33%)                       |
|FIRST INCIDENCE    |        736 (T)          736 (T)          736 (T)          736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.473N         P=0.043N*        P=0.287N         P=0.031N*        P=0.267N                         |
|POLY 3             |        P=0.159          P=0.140N         P=0.513          P=0.397N         P=0.365                          |
|POLY 1.5           |        P=0.130          P=0.147N         P=0.486          P=0.463N         P=0.323                          |
|POLY 6             |        P=0.217          P=0.137N         P=0.535          P=0.322N         P=0.440                          |
|LOGISTIC REGRESSION|        P=0.473N         P=0.043N*        P=0.287N         P=0.031N*        P=0.267N                         |
|COCH-ARM / FISHERS |        P=0.123          P=0.203N         P=0.361          P=0.622          P=0.291                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        11/60 (18%)      10/50 (20%)      8/50 (16%)       3/50 (6%)        16/60 (27%)                      |
|POLY-3 ADJUSTED (b)|        26.7%            23.4%            18.6%            7.4%             37.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        11/28 (39%)      10/33 (30%)      8/34 (24%)       3/28 (11%)       15/28 (54%)                      |
|FIRST INCIDENCE    |        738 (T)          738 (T)          738 (T)          738 (T)          690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.136          P=0.322N         P=0.146N         P=0.016N*        P=0.155                          |
|POLY 3             |        P=0.244          P=0.462N         P=0.266N         P=0.018N*        P=0.204                          |
|POLY 1.5           |        P=0.250          P=0.514N         P=0.305N         P=0.021N*        P=0.188                          |
|POLY 6             |        P=0.228          P=0.411N         P=0.236N         P=0.018N*        P=0.222                          |
|LOGISTIC REGRESSION|        P=0.145          P=0.322N         P=0.146N         P=0.016N*        P=0.179                          |
|COCH-ARM / FISHERS |        P=0.257          P=0.507          P=0.475N         P=0.047N*        P=0.191                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        2/50 (4%)        1/50 (2%)        9/50 (18%)       7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        5.3%             5.5%             2.6%             20.4%            16.8%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        1/21 (5%)        7/31 (23%)       7/27 (26%)                       |
|FIRST INCIDENCE    |        619              649              736 (T)          605              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.081          P=0.672N         P=0.393N         P=0.243          P=0.356                          |
|POLY 3             |        P=0.009 **       P=0.681          P=0.498N         P=0.045 *        P=0.101                          |
|POLY 1.5           |        P=0.007 **       P=0.676          P=0.508N         P=0.031 *        P=0.089                          |
|POLY 6             |        P=0.015 *        P=0.680          P=0.493N         P=0.068          P=0.124                          |
|LOGISTIC REGRESSION|        P=0.025 *        P=0.678          P=0.491N         P=0.058          P=0.173                          |
|COCH-ARM / FISHERS |        P=0.010 *        P=0.619          P=0.569N         P=0.012 *        P=0.081                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        1/50 (2%)        3/50 (6%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             2.3%             7.3%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        1/33 (3%)        1/34 (3%)        2/28 (7%)        2/28 (7%)                        |
|FIRST INCIDENCE    |        620              738 (T)          738 (T)          634              738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.381          P=0.454N         P=0.452N         P=0.491          P=0.690N                         |
|POLY 3             |        P=0.381          P=0.491N         P=0.489N         P=0.494          P=0.686N                         |
|POLY 1.5           |        P=0.385          P=0.506N         P=0.503N         P=0.486          P=0.692N                         |
|POLY 6             |        P=0.376          P=0.477N         P=0.480N         P=0.488          P=0.681N                         |
|LOGISTIC REGRESSION|        P=0.410          P=0.502N         P=0.499N         P=0.483          P=0.682N                         |
|COCH-ARM / FISHERS |        P=0.425          P=0.569N         P=0.569N         P=0.414          P=0.691N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        7/50 (14%)       6/50 (12%)       8/50 (16%)       5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             18.6%            15.1%            17.7%            11.9%                            |
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        3/16 (19%)       3/21 (14%)       5/31 (16%)       3/27 (11%)                       |
|FIRST INCIDENCE    |        184 (I)          505              521              213              715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.531N         P=0.015 *        P=0.039 *        P=0.043 *        P=0.281                          |
|POLY 3             |        P=0.279          P=0.025 *        P=0.059          P=0.030 *        P=0.120                          |
|POLY 1.5           |        P=0.232          P=0.024 *        P=0.052          P=0.020 *        P=0.109                          |
|POLY 6             |        P=0.368          P=0.026 *        P=0.066          P=0.045 *        P=0.144                          |
|LOGISTIC REGRESSION|        P=0.221          P=0.016 *        P=0.019 *        P=0.002 **       P=0.111                          |
|COCH-ARM / FISHERS |        P=0.214          P=0.016 *        P=0.033 *        P=0.007 **       P=0.103                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/60 (15%)       4/50 (8%)        7/50 (14%)       3/50 (6%)        13/60 (22%)                      |
|POLY-3 ADJUSTED (b)|        21.0%            9.0%             15.8%            7.3%             27.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)                       |
|TERMINAL (d)       |        6/28 (21%)       2/33 (6%)        5/34 (15%)       2/28 (7%)        3/28 (11%)                       |
|FIRST INCIDENCE    |        475              337              417              704              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.129          P=0.089N         P=0.285N         P=0.068N         P=0.280                          |
|POLY 3             |        P=0.120          P=0.099N         P=0.363N         P=0.067N         P=0.325                          |
|POLY 1.5           |        P=0.125          P=0.116N         P=0.397N         P=0.070N         P=0.293                          |
|POLY 6             |        P=0.113          P=0.087N         P=0.342N         P=0.073N         P=0.357                          |
|LOGISTIC REGRESSION|        P=0.145          P=0.188N         P=0.444N         P=0.070N         P=0.240                          |
|COCH-ARM / FISHERS |        P=0.136          P=0.203N         P=0.551N         P=0.114N         P=0.240                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        29/60 (48%)      16/50 (32%)      22/50 (44%)      22/50 (44%)      39/60 (65%)                      |
|POLY-3 ADJUSTED (b)|        58.1%            40.0%            52.0%            48.9%            74.3%                            |
|INT SACRIFICE 1 (c)|        7/10 (70%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         5/10 (50%)                       |
|TERMINAL (d)       |        9/12 (75%)       9/16 (56%)       13/21 (62%)      19/31 (61%)      20/27 (74%)                      |
|FIRST INCIDENCE    |        184 (I)          428              360              544              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.441N         P=0.080N         P=0.156N         P=0.003N**       P=0.329N                         |
|POLY 3             |        P=0.010 *        P=0.057N         P=0.346N         P=0.236N         P=0.052                          |
|POLY 1.5           |        P=0.006 **       P=0.050N         P=0.341N         P=0.287N         P=0.037 *                        |
|POLY 6             |        P=0.027 *        P=0.068N         P=0.354N         P=0.170N         P=0.101                          |
|LOGISTIC REGRESSION|        P=0.008 **       P=0.107N         P=0.511N         P=0.517N         P=0.047 *                        |
|COCH-ARM / FISHERS |        P=0.008 **       P=0.061N         P=0.397N         P=0.397N         P=0.048 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        41/60 (68%)      36/50 (72%)      33/50 (66%)      27/50 (54%)      46/60 (77%)                      |
|POLY-3 ADJUSTED (b)|        75.0%            78.5%            73.5%            62.9%            82.3%                            |
|INT SACRIFICE 1 (c)|        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        22/28 (79%)      29/33 (88%)      28/34 (82%)      19/28 (68%)      27/28 (96%)                      |
|FIRST INCIDENCE    |        184 (I)          284              399              592              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.242          P=0.557          P=0.323N         P=0.306N         P=0.236                          |
|POLY 3             |        P=0.334          P=0.429          P=0.523N         P=0.127N         P=0.226                          |
|POLY 1.5           |        P=0.331          P=0.410          P=0.501N         P=0.105N         P=0.204                          |
|POLY 6             |        P=0.305          P=0.475          P=0.547N         P=0.173N         P=0.229                          |
|LOGISTIC REGRESSION|        P=0.338          P=0.412          P=0.485N         P=0.095N         P=0.202                          |
|COCH-ARM / FISHERS |        P=0.349          P=0.418          P=0.477N         P=0.090N         P=0.207                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             0.0%             2.6%             2.3%             12.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        5/27 (19%)                       |
|FIRST INCIDENCE    |        736 (T)          ---              645              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.042 *        P=0.443N         P=0.711N         P=0.537N         P=0.371                          |
|POLY 3             |        P=0.014 *        P=0.508N         P=0.756N         P=0.726N         P=0.126                          |
|POLY 1.5           |        P=0.012 *        P=0.510N         P=0.758          P=0.749N         P=0.113                          |
|POLY 6             |        P=0.017 *        P=0.509N         P=0.748N         P=0.697N         P=0.151                          |
|LOGISTIC REGRESSION|        P=0.023 *        (e)              P=0.760N         P=0.537N         P=0.371                          |
|COCH-ARM / FISHERS |        P=0.012 *        P=0.545N         P=0.705          P=0.705          P=0.103                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       7/50 (14%)       5/50 (10%)       2/50 (4%)        5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        17.0%            16.4%            11.6%            4.9%             11.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        7/28 (25%)       7/33 (21%)       5/34 (15%)       2/28 (7%)        4/28 (14%)                       |
|FIRST INCIDENCE    |        738 (T)          738 (T)          738 (T)          738 (T)          714                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.187N         P=0.482N         P=0.244N         P=0.075N         P=0.372N                         |
|POLY 3             |        P=0.147N         P=0.586N         P=0.349N         P=0.079N         P=0.352N                         |
|POLY 1.5           |        P=0.148N         P=0.604          P=0.381N         P=0.085N         P=0.369N                         |
|POLY 6             |        P=0.151N         P=0.549N         P=0.325N         P=0.080N         P=0.334N                         |
|LOGISTIC REGRESSION|        P=0.183N         P=0.482N         P=0.244N         P=0.075N         P=0.353N                         |
|COCH-ARM / FISHERS |        P=0.156N         P=0.466          P=0.514N         P=0.133N         P=0.381N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Bile                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              725                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.202          (e)              (e)              (e)              P=0.624                          |
|POLY 3             |        P=0.163          (e)              (e)              (e)              P=0.522                          |
|POLY 1.5           |        P=0.158          (e)              (e)              (e)              P=0.510                          |
|POLY 6             |        P=0.173          (e)              (e)              (e)              P=0.540                          |
|LOGISTIC REGRESSION|        P=0.182          (e)              (e)              (e)              P=0.575                          |
|COCH-ARM / FISHERS |        P=0.160          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Bile                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.6%             2.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        1/34 (3%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              620              738 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.304N         P=0.271          P=0.539          (e)              (e)                              |
|POLY 3             |        P=0.245N         P=0.248          P=0.508          (e)              (e)                              |
|POLY 1.5           |        P=0.255N         P=0.235          P=0.499          (e)              (e)                              |
|POLY 6             |        P=0.241N         P=0.262          P=0.515          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.294N         P=0.212          P=0.539          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.295N         P=0.204          P=0.455          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             4.6%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        704              ---              ---              ---              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.215          P=0.471N         P=0.477N         P=0.513N         P=0.526                          |
|POLY 3             |        P=0.206          P=0.493N         P=0.492N         P=0.503N         P=0.519                          |
|POLY 1.5           |        P=0.211          P=0.503N         P=0.501N         P=0.506N         P=0.508                          |
|POLY 6             |        P=0.200          P=0.485N         P=0.486N         P=0.506N         P=0.529                          |
|LOGISTIC REGRESSION|        P=0.234          P=0.498N         P=0.496N         P=0.505N         P=0.500                          |
|COCH-ARM / FISHERS |        P=0.225          P=0.545N         P=0.545N         P=0.545N         P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.7%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        391              698              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.063N         P=0.462N         P=0.220N         P=0.243N         P=0.241N                         |
|POLY 3             |        P=0.065N         P=0.494N         P=0.233N         P=0.244N         P=0.234N                         |
|POLY 1.5           |        P=0.064N         P=0.509N         P=0.241N         P=0.247N         P=0.238N                         |
|POLY 6             |        P=0.068N         P=0.479N         P=0.227N         P=0.248N         P=0.231N                         |
|LOGISTIC REGRESSION|        P=0.068N         P=0.606N         P=0.339N         P=0.331N         P=0.238N                         |
|COCH-ARM / FISHERS |        P=0.065N         P=0.569N         P=0.295N         P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Artery                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.6%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.123          (e)              (e)              (e)              P=0.234                          |
|POLY 3             |        P=0.038 *        (e)              (e)              (e)              P=0.273                          |
|POLY 1.5           |        P=0.036 *        (e)              (e)              (e)              P=0.257                          |
|POLY 6             |        P=0.042 *        (e)              (e)              (e)              P=0.296                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.036 *        (e)              (e)              (e)              P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Artery                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        49/60 (82%)      47/50 (94%)      46/50 (92%)      48/50 (96%)      48/60 (80%)                      |
|POLY-3 ADJUSTED (b)|        98.8%            95.4%            94.6%            99.1%            96.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)                       |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     20/21 (95%)      31/31 (100%)     27/27 (100%)                     |
|FIRST INCIDENCE    |        396              410              443              518              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.313N         P=0.062N         P<0.001N**       P=0.002N**                       |
|POLY 3             |        P=0.494N         P=0.323N         P=0.247N         P=0.916          P=0.378N                         |
|POLY 1.5           |        P=0.390N         P=0.571N         P=0.447N         P=0.474          P=0.354N                         |
|POLY 6             |        P=0.577N         P=0.293N         P=0.227N         P=1.000          P=0.477N                         |
|LOGISTIC REGRESSION|        P=0.382N         P=0.592N         P=0.274N         P=0.409N         P=0.477N                         |
|COCH-ARM / FISHERS |        P=0.304N         P=0.047 *        P=0.097          P=0.019 *        P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/60 (40%)      18/50 (36%)      22/50 (44%)      19/50 (38%)      18/60 (30%)                      |
|POLY-3 ADJUSTED (b)|        55.9%            39.5%            46.8%            44.3%            41.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        16/28 (57%)      10/33 (30%)      13/34 (38%)      14/28 (50%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        585              430              535              586              647                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.262N         P=0.073N         P=0.218N         P=0.238N         P=0.146N                         |
|POLY 3             |        P=0.224N         P=0.086N         P=0.255N         P=0.187N         P=0.122N                         |
|POLY 1.5           |        P=0.205N         P=0.139N         P=0.368N         P=0.226N         P=0.141N                         |
|POLY 6             |        P=0.262N         P=0.055N         P=0.176N         P=0.189N         P=0.111N                         |
|LOGISTIC REGRESSION|        P=0.163N         P=0.138N         P=0.398N         P=0.218N         P=0.085N                         |
|COCH-ARM / FISHERS |        P=0.155N         P=0.409N         P=0.409          P=0.493N         P=0.169N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             6.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.056          (e)              (e)              (e)              P=0.111                          |
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              P=0.153                          |
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              P=0.139                          |
|POLY 6             |        P=0.011 *        (e)              (e)              (e)              P=0.175                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.009 **       (e)              (e)              (e)              P=0.122                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.5%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)                       |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.123          (e)              (e)              (e)              P=0.234                          |
|POLY 3             |        P=0.033 *        (e)              (e)              (e)              P=0.255                          |
|POLY 1.5           |        P=0.034 *        (e)              (e)              (e)              P=0.248                          |
|POLY 6             |        P=0.033 *        (e)              (e)              (e)              P=0.261                          |
|LOGISTIC REGRESSION|        P=0.148          (e)              (e)              (e)              P=0.291                          |
|COCH-ARM / FISHERS |        P=0.036 *        (e)              (e)              (e)              P=0.248                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        16/60 (27%)      22/50 (44%)      28/50 (56%)      39/50 (78%)      28/60 (47%)                      |
|POLY-3 ADJUSTED (b)|        39.9%            55.6%            65.2%            81.7%            62.8%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       11/16 (69%)      14/21 (67%)      24/31 (77%)      16/27 (59%)                      |
|FIRST INCIDENCE    |        576              507              527              561              550                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.431N         P=0.289          P=0.182          P=0.218          P=0.532                          |
|POLY 3             |        P=0.005 **       P=0.107          P=0.013 *        P<0.001 **       P=0.023 *                        |
|POLY 1.5           |        P=0.002 **       P=0.103          P=0.008 **       P<0.001 **       P=0.015 *                        |
|POLY 6             |        P=0.026 *        P=0.097          P=0.018 *        P<0.001 **       P=0.049 *                        |
|LOGISTIC REGRESSION|        P=0.010 *        P=0.099          P=0.011 *        P<0.001 **       P=0.039 *                        |
|COCH-ARM / FISHERS |        P=0.004 **       P=0.044 *        P=0.002 **       P<0.001 **       P=0.018 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.536          (e)              (e)              P=0.500          (e)                              |
|POLY 3             |        P=0.502          (e)              (e)              P=0.497          (e)                              |
|POLY 1.5           |        P=0.501          (e)              (e)              P=0.494          (e)                              |
|POLY 6             |        P=0.510          (e)              (e)              P=0.495          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.500          (e)                              |
|COCH-ARM / FISHERS |        P=0.549          (e)              (e)              P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        0/50 (0%)        2/50 (4%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        7.7%             0.0%             5.2%             2.3%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        535              ---              521              736 (T)          536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.394N         P=0.139N         P=0.451N         P=0.188N         P=0.423N                         |
|POLY 3             |        P=0.487N         P=0.130N         P=0.500N         P=0.265N         P=0.458N                         |
|POLY 1.5           |        P=0.510N         P=0.130N         P=0.511N         P=0.292N         P=0.480N                         |
|POLY 6             |        P=0.450N         P=0.134N         P=0.495N         P=0.238N         P=0.423N                         |
|LOGISTIC REGRESSION|        P=0.517N         P=0.148N         P=0.581N         P=0.344N         P=0.493N                         |
|COCH-ARM / FISHERS |        P=0.518N         P=0.159N         P=0.586N         P=0.381N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        2/50 (4%)        0/50 (0%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             4.7%             0.0%             8.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)                       |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        2/34 (6%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              337              738 (T)          ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.072          P=0.496          P=0.282          (e)              P=0.062                          |
|POLY 3             |        P=0.039 *        P=0.511          P=0.246          (e)              P=0.075                          |
|POLY 1.5           |        P=0.039 *        P=0.500          P=0.236          (e)              P=0.070                          |
|POLY 6             |        P=0.039 *        P=0.521          P=0.255          (e)              P=0.080                          |
|LOGISTIC REGRESSION|        P=0.078          P=0.207          P=0.282          (e)              P=0.068                          |
|COCH-ARM / FISHERS |        P=0.036 *        P=0.455          P=0.204          (e)              P=0.059                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      3/50 (6%)        5/50 (10%)       7/50 (14%)       21/60 (35%)                      |
|POLY-3 ADJUSTED (b)|        24.5%            8.0%             13.0%            15.7%            41.1%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         8/10 (80%)                       |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        4/21 (19%)       6/31 (19%)       10/27 (37%)                      |
|FIRST INCIDENCE    |        396              450              676              213              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.026 *        P=0.050N         P=0.071N         P=0.051N         P=0.166                          |
|POLY 3             |        P<0.001 **       P=0.044N*        P=0.150N         P=0.228N         P=0.071                          |
|POLY 1.5           |        P<0.001 **       P=0.045N*        P=0.154N         P=0.275N         P=0.050                          |
|POLY 6             |        P=0.003 **       P=0.049N*        P=0.159N         P=0.188N         P=0.102                          |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.066N         P=0.149N         P=0.394N         P=0.015 *                        |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.074N         P=0.232N         P=0.455N         P=0.018 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       2/50 (4%)        1/50 (2%)        3/50 (6%)        9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        16.7%            4.5%             2.3%             7.3%             20.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       0/33 (0%)        1/34 (3%)        1/28 (4%)        6/28 (21%)                       |
|FIRST INCIDENCE    |        645              337              738 (T)          613              684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.118          P=0.065N         P=0.022N*        P=0.188N         P=0.417                          |
|POLY 3             |        P=0.116          P=0.065N         P=0.027N*        P=0.160N         P=0.416                          |
|POLY 1.5           |        P=0.126          P=0.078N         P=0.031N*        P=0.168N         P=0.400                          |
|POLY 6             |        P=0.106          P=0.057N         P=0.024N*        P=0.163N         P=0.430                          |
|LOGISTIC REGRESSION|        P=0.141          P=0.113N         P=0.026N*        P=0.168N         P=0.437                          |
|COCH-ARM / FISHERS |        P=0.157          P=0.133N         P=0.053N         P=0.246N         P=0.395                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        1/50 (2%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             2.8%             2.6%             2.3%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        617              726              593              621              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.518N         P=0.488N         P=0.466N         P=0.387N         P=0.588N                         |
|POLY 3             |        P=0.579          P=0.518N         P=0.494N         P=0.450N         P=0.653N                         |
|POLY 1.5           |        P=0.556          P=0.519N         P=0.506N         P=0.482N         P=0.674N                         |
|POLY 6             |        P=0.553N         P=0.523N         P=0.486N         P=0.414N         P=0.619N                         |
|LOGISTIC REGRESSION|        P=0.550          P=0.516N         P=0.534N         P=0.529N         P=0.683N                         |
|COCH-ARM / FISHERS |        P=0.547          P=0.569N         P=0.569N         P=0.569N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             2.5%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              733              738 (T)          704                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.057          (e)              P=0.545          P=0.500          P=0.257                          |
|POLY 3             |        P=0.068          (e)              P=0.508          P=0.497          P=0.246                          |
|POLY 1.5           |        P=0.068          (e)              P=0.499          P=0.494          P=0.240                          |
|POLY 6             |        P=0.068          (e)              P=0.515          P=0.495          P=0.252                          |
|LOGISTIC REGRESSION|        P=0.064          (e)              P=0.524          P=0.500          P=0.246                          |
|COCH-ARM / FISHERS |        P=0.075          (e)              P=0.455          P=0.455          P=0.248                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             14.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         6/10 (60%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.005 **                       |
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.021 *                        |
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.016 *                        |
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.030 *                        |
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.003 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.006 **                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        6/60 (10%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             12.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         6/10 (60%)                       |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              P=0.009 **                       |
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.027 *                        |
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.023 *                        |
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.029 *                        |
|LOGISTIC REGRESSION|        P=0.006 **       (e)              (e)              (e)              P=0.017 *                        |
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.014 *                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        4/50 (8%)        1/50 (2%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             10.7%            2.6%             4.6%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        729              410              640              708              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.230N         P=0.390          P=0.400N         P=0.381N         P=0.520N                         |
|POLY 3             |        P=0.328N         P=0.333          P=0.491N         P=0.638N         P=0.649N                         |
|POLY 1.5           |        P=0.359N         P=0.322          P=0.505N         P=0.675N         P=0.672N                         |
|POLY 6             |        P=0.286N         P=0.340          P=0.480N         P=0.594N         P=0.610N                         |
|LOGISTIC REGRESSION|        P=0.388N         P=0.302          P=0.486N         P=0.515N         P=0.671N                         |
|COCH-ARM / FISHERS |        P=0.402N         P=0.257          P=0.569N         P=0.619          P=0.691N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.7%             0.0%             4.6%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        391              ---              399              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.133N         P=0.244N         P=0.668N         P=0.230N         P=0.237N                         |
|POLY 3             |        P=0.149N         P=0.236N         P=0.684N         P=0.247N         P=0.237N                         |
|POLY 1.5           |        P=0.145N         P=0.244N         P=0.690          P=0.248N         P=0.239N                         |
|POLY 6             |        P=0.157N         P=0.229N         P=0.675N         P=0.252N         P=0.235N                         |
|LOGISTIC REGRESSION|        P=0.138N         P=0.390N         P=0.457          P=0.404N         P=0.234N                         |
|COCH-ARM / FISHERS |        P=0.137N         P=0.295N         P=0.619          P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      0/50 (0%)        5/50 (10%)       4/50 (8%)        12/60 (20%)                      |
|POLY-3 ADJUSTED (b)|        21.8%            0.0%             13.0%            9.2%             25.1%                            |
|INT SACRIFICE 1 (c)|        7/10 (70%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         6/10 (60%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        4/21 (19%)       4/31 (13%)       5/27 (19%)                       |
|FIRST INCIDENCE    |        184 (I)          ---              676              736 (T)          184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.416          P=0.126N         P=0.533          P=0.478N         P=0.575N                         |
|POLY 3             |        P=0.132          P=0.003N**       P=0.220N         P=0.085N         P=0.449                          |
|POLY 1.5           |        P=0.108          P=0.002N**       P=0.216N         P=0.103N         P=0.417                          |
|POLY 6             |        P=0.177          P=0.003N**       P=0.226N         P=0.064N         P=0.514                          |
|LOGISTIC REGRESSION|        P=0.107          P=0.094N         P=0.502          P=0.540          P=0.350                          |
|COCH-ARM / FISHERS |        P=0.098          P=0.002N**       P=0.232N         P=0.142N         P=0.407                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        19/60 (32%)      12/50 (24%)      17/50 (34%)      15/50 (30%)      20/60 (33%)                      |
|POLY-3 ADJUSTED (b)|        37.9%            27.4%            39.6%            36.1%            41.0%                            |
|INT SACRIFICE 1 (c)|        7/10 (70%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         5/10 (50%)                       |
|TERMINAL (d)       |        7/28 (25%)       10/33 (30%)      17/34 (50%)      13/28 (46%)      12/28 (43%)                      |
|FIRST INCIDENCE    |        184 (I)          522              738 (T)          605              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.309          P=0.447N         P=0.362          P=0.315          P=0.521                          |
|POLY 3             |        P=0.263          P=0.191N         P=0.521          P=0.515N         P=0.458                          |
|POLY 1.5           |        P=0.276          P=0.206N         P=0.524          P=0.486N         P=0.452                          |
|POLY 6             |        P=0.239          P=0.173N         P=0.506          P=0.577N         P=0.460                          |
|LOGISTIC REGRESSION|        P=0.349          P=0.435N         P=0.344          P=0.506          P=0.499                          |
|COCH-ARM / FISHERS |        P=0.341          P=0.250N         P=0.477          P=0.508N         P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 51
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        5/50 (10%)       3/50 (6%)        2/50 (4%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             13.5%            7.8%             4.6%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        3/16 (19%)       2/21 (10%)       2/31 (7%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        736 (T)          435              593              736 (T)          460                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.314N         P=0.153          P=0.459          P=0.672N         P=0.538                          |
|POLY 3             |        P=0.501N         P=0.095          P=0.314          P=0.551          P=0.351                          |
|POLY 1.5           |        P=0.547N         P=0.092          P=0.300          P=0.518          P=0.328                          |
|POLY 6             |        P=0.438N         P=0.095          P=0.327          P=0.589          P=0.388                          |
|LOGISTIC REGRESSION|        P=0.549          P=0.091          P=0.317          P=0.672N         P=0.329                          |
|COCH-ARM / FISHERS |        P=0.507          P=0.067          P=0.244          P=0.431          P=0.309                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        2/50 (4%)        5/50 (10%)       3/50 (6%)        5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        12.0%            4.7%             11.6%            7.2%             11.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/28 (14%)       1/33 (3%)        4/34 (12%)       1/28 (4%)        4/28 (14%)                       |
|FIRST INCIDENCE    |        645              731              690              588              684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.413          P=0.164N         P=0.525N         P=0.360N         P=0.619N                         |
|POLY 3             |        P=0.435          P=0.203N         P=0.607N         P=0.354N         P=0.612N                         |
|POLY 1.5           |        P=0.440          P=0.222N         P=0.627          P=0.368N         P=0.624N                         |
|POLY 6             |        P=0.425          P=0.187N         P=0.587N         P=0.354N         P=0.600N                         |
|LOGISTIC REGRESSION|        P=0.452          P=0.182N         P=0.582N         P=0.380N         P=0.596N                         |
|COCH-ARM / FISHERS |        P=0.471          P=0.301N         P=0.509          P=0.464N         P=0.628N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 52
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        39/60 (65%)      37/50 (74%)      39/50 (78%)      40/50 (80%)      44/60 (73%)                      |
|POLY-3 ADJUSTED (b)|        84.1%            81.9%            84.1%            86.4%            90.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        10/12 (83%)      11/16 (69%)      18/21 (86%)      28/31 (90%)      24/27 (89%)                      |
|FIRST INCIDENCE    |        396              435              443              544              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.344N         P=0.143N         P<0.001N**       P=0.034N*                        |
|POLY 3             |        P=0.147          P=0.497N         P=0.621          P=0.490          P=0.274                          |
|POLY 1.5           |        P=0.112          P=0.566N         P=0.506          P=0.375          P=0.196                          |
|POLY 6             |        P=0.223          P=0.474N         P=0.616N         P=0.524          P=0.406                          |
|LOGISTIC REGRESSION|        P=0.201          P=0.565N         P=0.538          P=0.413N         P=0.236                          |
|COCH-ARM / FISHERS |        P=0.182          P=0.209          P=0.099          P=0.062          P=0.215                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        41/60 (68%)      42/50 (84%)      45/50 (90%)      46/50 (92%)      46/60 (77%)                      |
|POLY-3 ADJUSTED (b)|        88.7%            90.5%            93.8%            96.0%            96.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        28/28 (100%)     32/33 (97%)      33/34 (97%)      28/28 (100%)     28/28 (100%)                     |
|FIRST INCIDENCE    |        461              430              399              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.071          P=0.221N         P=0.365N         P=0.218          P=0.298                          |
|POLY 3             |        P=0.041 *        P=0.527          P=0.280          P=0.124          P=0.117                          |
|POLY 1.5           |        P=0.043 *        P=0.349          P=0.140          P=0.058          P=0.093                          |
|POLY 6             |        P=0.046 *        P=0.668N         P=0.385          P=0.152          P=0.181                          |
|LOGISTIC REGRESSION|        P=0.045 *        P=0.492          P=0.206          P=0.095          P=0.124                          |
|COCH-ARM / FISHERS |        P=0.188          P=0.045 *        P=0.005 **       P=0.002 **       P=0.207                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 53
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        2/50 (4%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.2%             2.3%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        1/31 (3%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              666              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.437          (e)              P=0.300          P=0.689          P=0.662                          |
|POLY 3             |        P=0.308          (e)              P=0.242          P=0.529          P=0.521                          |
|POLY 1.5           |        P=0.282          (e)              P=0.233          P=0.510          P=0.510                          |
|POLY 6             |        P=0.356          (e)              P=0.249          P=0.551          P=0.539                          |
|LOGISTIC REGRESSION|        P=0.343          (e)              P=0.245          P=0.689          P=0.662                          |
|COCH-ARM / FISHERS |        P=0.276          (e)              P=0.204          P=0.455          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/49 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        698              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.247N         P=0.468N         P=0.489N         P=0.525N         P=0.483N                         |
|POLY 3             |        P=0.258N         P=0.498N         P=0.493N         P=0.503N         P=0.494N                         |
|POLY 1.5           |        P=0.250N         P=0.507N         P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.268N         P=0.490N         P=0.487N         P=0.506N         P=0.490N                         |
|LOGISTIC REGRESSION|        P=0.242N         P=0.506N         P=0.500N         P=0.507N         P=0.494N                         |
|COCH-ARM / FISHERS |        P=0.247N         P=0.550N         P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 54
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        3/50 (6%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             7.9%             0.0%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        3/21 (14%)       0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          736 (T)          ---              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.460N         P=0.557          P=0.232          (e)              P=0.662                          |
|POLY 3             |        P=0.589          P=0.492          P=0.120          (e)              P=0.521                          |
|POLY 1.5           |        P=0.552          P=0.490          P=0.115          (e)              P=0.510                          |
|POLY 6             |        P=0.557N         P=0.491          P=0.124          (e)              P=0.539                          |
|LOGISTIC REGRESSION|        (e)              P=0.557          P=0.232          (e)              P=0.662                          |
|COCH-ARM / FISHERS |        P=0.511          P=0.455          P=0.091          (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 55
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/60 (42%)      19/50 (38%)      23/50 (46%)      36/50 (72%)      24/60 (40%)                      |
|POLY-3 ADJUSTED (b)|        57.8%            46.6%            55.8%            77.6%            53.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       7/16 (44%)       11/21 (52%)      25/31 (81%)      13/27 (48%)                      |
|FIRST INCIDENCE    |        396              507              593              605              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.044N*        P=0.156N         P=0.147N         P=0.127N         P=0.035N*                        |
|POLY 3             |        P=0.242          P=0.198N         P=0.515N         P=0.028 *        P=0.418N                         |
|POLY 1.5           |        P=0.188          P=0.213N         P=0.526N         P=0.013 *        P=0.468N                         |
|POLY 6             |        P=0.379          P=0.214N         P=0.546N         P=0.053          P=0.337N                         |
|LOGISTIC REGRESSION|        P=0.399          P=0.228N         P=0.418N         P=0.060          P=0.364N                         |
|COCH-ARM / FISHERS |        P=0.253          P=0.423N         P=0.396          P<0.001 **       P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        30/60 (50%)      22/50 (44%)      21/50 (42%)      24/50 (48%)      26/60 (43%)                      |
|POLY-3 ADJUSTED (b)|        65.8%            48.4%            43.9%            52.9%            56.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        18/28 (64%)      14/33 (42%)      11/34 (32%)      13/28 (46%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        507              337              399              417              571                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.480N         P=0.038N*        P=0.032N*        P=0.223N         P=0.261N                         |
|POLY 3             |        P=0.407N         P=0.066N         P=0.024N*        P=0.141N         P=0.241N                         |
|POLY 1.5           |        P=0.406N         P=0.093N         P=0.043N*        P=0.176N         P=0.268N                         |
|POLY 6             |        P=0.409N         P=0.055N         P=0.017N*        P=0.146N         P=0.217N                         |
|LOGISTIC REGRESSION|        P=0.368N         P=0.089N         P=0.090N         P=0.209N         P=0.225N                         |
|COCH-ARM / FISHERS |        P=0.333N         P=0.332N         P=0.259N         P=0.493N         P=0.292N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 56
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        2/49 (4%)        6/60 (10%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             4.7%             14.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/30 (3%)        5/27 (19%)                       |
|FIRST INCIDENCE    |        ---              ---              666              684              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.003 **       (e)              P=0.500          P=0.385          P=0.084                          |
|POLY 3             |        P<0.001 **       (e)              P=0.505          P=0.268          P=0.022 *                        |
|POLY 1.5           |        P<0.001 **       (e)              P=0.497          P=0.245          P=0.019 *                        |
|POLY 6             |        P<0.001 **       (e)              P=0.511          P=0.297          P=0.030 *                        |
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.493          P=0.281          P=0.031 *                        |
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.455          P=0.200          P=0.014 *                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        3/50 (6%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             7.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        3/34 (9%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              738 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.575N         (e)              P=0.157          (e)              (e)                              |
|POLY 3             |        P=0.534N         (e)              P=0.126          (e)              (e)                              |
|POLY 1.5           |        P=0.535N         (e)              P=0.118          (e)              (e)                              |
|POLY 6             |        P=0.540N         (e)              P=0.133          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.157          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.543N         (e)              P=0.091          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 57
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             7.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/30 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.012 *        (e)              (e)              (e)              P=0.201                          |
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              P=0.143                          |
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              P=0.131                          |
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              P=0.165                          |
|LOGISTIC REGRESSION|        P=0.010 *        (e)              (e)              (e)              P=0.122                          |
|COCH-ARM / FISHERS |        P=0.009 **       (e)              (e)              (e)              P=0.122                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 58
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/59 (0%)        0/47 (0%)        1/50 (2%)        1/49 (2%)        2/58 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             2.3%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)                         |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        ---              ---              722              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.146          (e)              P=0.560          P=0.689          P=0.429                          |
|POLY 3             |        P=0.085          (e)              P=0.507          P=0.530          P=0.263                          |
|POLY 1.5           |        P=0.077          (e)              P=0.500          P=0.511          P=0.249                          |
|POLY 6             |        P=0.101          (e)              P=0.513          P=0.552          P=0.286                          |
|LOGISTIC REGRESSION|        P=0.124          (e)              P=0.527          P=0.689          P=0.429                          |
|COCH-ARM / FISHERS |        P=0.075          (e)              P=0.459          P=0.454          P=0.244                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             4.7%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          731              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.046N*        P=0.634N         P=0.196N         P=0.238N         P=0.238N                         |
|POLY 3             |        P=0.043N*        P=0.681N         P=0.228N         P=0.239N         P=0.229N                         |
|POLY 1.5           |        P=0.044N*        P=0.690          P=0.238N         P=0.243N         P=0.234N                         |
|POLY 6             |        P=0.044N*        P=0.663N         P=0.221N         P=0.242N         P=0.224N                         |
|LOGISTIC REGRESSION|        P=0.045N*        P=0.635N         (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.049N*        P=0.619          P=0.295N         P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 59
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        36/59 (61%)      34/47 (72%)      24/50 (48%)      28/49 (57%)      26/58 (45%)                      |
|POLY-3 ADJUSTED (b)|        79.4%            79.9%            56.7%            62.6%            60.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)                         |
|TERMINAL (d)       |        8/12 (67%)       11/16 (69%)      11/21 (52%)      20/31 (65%)      18/27 (67%)                      |
|FIRST INCIDENCE    |        396              524              443              561              613                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.346N         P=0.005N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.009N**       P=0.589          P=0.012N*        P=0.052N         P=0.036N*                        |
|POLY 1.5           |        P=0.010N*        P=0.520          P=0.014N*        P=0.085N         P=0.035N*                        |
|POLY 6             |        P=0.008N**       P=0.610          P=0.020N*        P=0.043N*        P=0.038N*                        |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.565          P=0.010N*        P=0.023N*        P=0.007N**                       |
|COCH-ARM / FISHERS |        P=0.014N*        P=0.155          P=0.121N         P=0.416N         P=0.058N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        43/60 (72%)      44/50 (88%)      45/50 (90%)      42/50 (84%)      45/60 (75%)                      |
|POLY-3 ADJUSTED (b)|        87.9%            93.4%            94.3%            86.4%            93.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        24/28 (86%)      32/33 (97%)      32/34 (94%)      24/28 (86%)      27/28 (96%)                      |
|FIRST INCIDENCE    |        461              392              451              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.306          P=0.267N         P=0.288N         P=0.513N         P=0.509                          |
|POLY 3             |        P=0.387          P=0.275          P=0.216          P=0.533N         P=0.240                          |
|POLY 1.5           |        P=0.413          P=0.216          P=0.163          P=0.616          P=0.265                          |
|POLY 6             |        P=0.342          P=0.271          P=0.212          P=0.574N         P=0.213                          |
|LOGISTIC REGRESSION|        P=0.457          P=0.358          P=0.343          P=0.537          P=0.408                          |
|COCH-ARM / FISHERS |        P=0.477N         P=0.030 *        P=0.014 *        P=0.095          P=0.418                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 60
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        12/15 (80%)      8/12 (67%)       8/15 (53%)       8/11 (73%)       11/15 (73%)                      |
|POLY-3 ADJUSTED (b)|        83.4%            73.2%            60.3%            77.5%            87.8%                            |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        3/3 (100%)       0/1 (0%)         3/6 (50%)        5/5 (100%)       9/9 (100%)                       |
|FIRST INCIDENCE    |        593              534              563              610              680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.012N*        P=0.393N         P=0.091N         P=0.025N*        P=0.012N*                        |
|POLY 3             |        P=0.397          P=0.443N         P=0.158N         P=0.560N         P=0.603                          |
|POLY 1.5           |        P=0.470          P=0.408N         P=0.140N         P=0.542N         P=0.691                          |
|POLY 6             |        P=0.335          P=0.495N         P=0.188N         P=0.574N         P=0.506                          |
|LOGISTIC REGRESSION|        P=0.462N         P=0.302N         P=0.119N         P=0.497N         P=0.542N                         |
|COCH-ARM / FISHERS |        P=0.519N         P=0.364N         P=0.123N         P=0.509N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/8 (38%)        0/1 (0%)         3/5 (60%)        1/5 (20%)        3/6 (50%)                        |
|POLY-3 ADJUSTED (b)|        42.2%            0.0%             71.7%            25.2%            60.9%                            |
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         |
|TERMINAL (d)       |        2/5 (40%)        0/1 (0%)         2/2 (100%)       1/2 (50%)        1/1 (100%)                       |
|FIRST INCIDENCE    |        391              ---              684              738 (T)          600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.108          P=0.322N         P=0.358          P=0.575N         P=0.316                          |
|POLY 3             |        P=0.368          P=0.611N         P=0.367          P=0.532N         P=0.479                          |
|POLY 1.5           |        P=0.408          P=0.620N         P=0.396          P=0.503N         P=0.503                          |
|POLY 6             |        P=0.299          P=0.599N         P=0.308          P=0.591N         P=0.441                          |
|LOGISTIC REGRESSION|        P=0.438          P=0.714N         P=0.419          P=0.495N         P=0.531                          |
|COCH-ARM / FISHERS |        P=0.449          P=0.667N         P=0.413          P=0.490N         P=0.529                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 61
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Fungus                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        21/60 (35%)      15/50 (30%)      10/50 (20%)      11/50 (22%)      7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        48.9%            36.9%            24.9%            24.2%            16.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/12 (50%)       3/16 (19%)       5/21 (24%)       6/31 (19%)       2/27 (7%)                        |
|FIRST INCIDENCE    |        396              450              557              544              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.157N         P=0.004N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P<0.001N**       P=0.178N         P=0.016N*        P=0.012N*        P<0.001N**                       |
|POLY 1.5           |        P<0.001N**       P=0.192N         P=0.019N*        P=0.021N*        P<0.001N**                       |
|POLY 6             |        P<0.001N**       P=0.174N         P=0.017N*        P=0.006N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.237N         P=0.021N*        P=0.028N*        P<0.001N**                       |
|COCH-ARM / FISHERS |        P<0.001N**       P=0.363N         P=0.062N         P=0.099N         P=0.002N**                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Fungus                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       2/50 (4%)        1/50 (2%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        13.8%            4.6%             2.3%             0.0%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        1/34 (3%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        461              337              738 (T)          ---              652                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.054N         P=0.123N         P=0.051N         P=0.021N*        P=0.135N                         |
|POLY 3             |        P=0.057N         P=0.128N         P=0.056N         P=0.018N*        P=0.134N                         |
|POLY 1.5           |        P=0.055N         P=0.140N         P=0.061N         P=0.018N*        P=0.137N                         |
|POLY 6             |        P=0.062N         P=0.119N         P=0.055N         P=0.020N*        P=0.133N                         |
|LOGISTIC REGRESSION|        P=0.053N         P=0.242N         P=0.085N         P=0.028N*        P=0.134N                         |
|COCH-ARM / FISHERS |        P=0.052N         P=0.203N         P=0.091N         P=0.023N*        P=0.136N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 62
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        28/60 (47%)      19/50 (38%)      22/50 (44%)      18/50 (36%)      22/60 (37%)                      |
|POLY-3 ADJUSTED (b)|        60.1%            46.7%            52.8%            39.5%            49.7%                            |
|INT SACRIFICE 1 (c)|        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        7/12 (58%)       7/16 (44%)       13/21 (62%)      11/31 (36%)      13/27 (48%)                      |
|FIRST INCIDENCE    |        184 (I)          450              521              544              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.142N         P=0.075N         P<0.001N**       P=0.004N**                       |
|POLY 3             |        P=0.152N         P=0.136N         P=0.306N         P=0.032N*        P=0.207N                         |
|POLY 1.5           |        P=0.183N         P=0.133N         P=0.306N         P=0.053N         P=0.210N                         |
|POLY 6             |        P=0.102N         P=0.153N         P=0.339N         P=0.018N*        P=0.176N                         |
|LOGISTIC REGRESSION|        P=0.121N         P=0.161N         P=0.300N         P=0.096N         P=0.132N                         |
|COCH-ARM / FISHERS |        P=0.162N         P=0.236N         P=0.465N         P=0.175N         P=0.177N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        17/60 (28%)      13/50 (26%)      7/50 (14%)       6/50 (12%)       8/60 (13%)                       |
|POLY-3 ADJUSTED (b)|        35.7%            28.9%            16.1%            14.4%            17.7%                            |
|INT SACRIFICE 1 (c)|        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        7/28 (25%)       8/33 (24%)       6/34 (18%)       4/28 (14%)       3/28 (11%)                       |
|FIRST INCIDENCE    |        184 (I)          337              544              571              11                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.013N*        P=0.450N         P=0.062N         P=0.072N         P=0.041N*                        |
|POLY 3             |        P=0.011N*        P=0.317N         P=0.026N*        P=0.017N*        P=0.039N*                        |
|POLY 1.5           |        P=0.010N*        P=0.352N         P=0.030N*        P=0.017N*        P=0.040N*                        |
|POLY 6             |        P=0.013N*        P=0.283N         P=0.024N*        P=0.020N*        P=0.038N*                        |
|LOGISTIC REGRESSION|        P=0.008N**       P=0.573N         P=0.091N         P=0.054N         P=0.035N*                        |
|COCH-ARM / FISHERS |        P=0.009N**       P=0.478N         P=0.056N         P=0.030N*        P=0.035N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 63
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       6/50 (12%)       6/50 (12%)       5/50 (10%)       4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        15.6%            16.3%            14.9%            11.5%            9.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        2/16 (13%)       2/21 (10%)       4/31 (13%)       1/27 (4%)                        |
|FIRST INCIDENCE    |        617              631              482              712              613                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.053N         P=0.544N         P=0.469N         P=0.118N         P=0.157N                         |
|POLY 3             |        P=0.176N         P=0.592          P=0.589N         P=0.409N         P=0.302N                         |
|POLY 1.5           |        P=0.214N         P=0.585          P=0.621N         P=0.469N         P=0.336N                         |
|POLY 6             |        P=0.127N         P=0.588          P=0.563N         P=0.347N         P=0.252N                         |
|LOGISTIC REGRESSION|        P=0.186N         P=0.595          P=0.588          P=0.307N         P=0.299N                         |
|COCH-ARM / FISHERS |        P=0.248N         P=0.486          P=0.486          P=0.622          P=0.372N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/60 (15%)       6/50 (12%)       10/50 (20%)      6/50 (12%)       10/60 (17%)                      |
|POLY-3 ADJUSTED (b)|        21.1%            13.9%            22.6%            14.2%            22.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/28 (18%)       4/33 (12%)       6/34 (18%)       3/28 (11%)       5/28 (18%)                       |
|FIRST INCIDENCE    |        523              701              600              459              11                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.356          P=0.200N         P=0.554N         P=0.301N         P=0.528                          |
|POLY 3             |        P=0.409          P=0.279N         P=0.535          P=0.289N         P=0.537                          |
|POLY 1.5           |        P=0.413          P=0.307N         P=0.493          P=0.304N         P=0.521                          |
|POLY 6             |        P=0.398          P=0.255N         P=0.567          P=0.295N         P=0.552                          |
|LOGISTIC REGRESSION|        P=0.409          P=0.275N         P=0.498          P=0.344N         P=0.512                          |
|COCH-ARM / FISHERS |        P=0.429          P=0.432N         P=0.330          P=0.432N         P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 64
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/60 (40%)      16/50 (32%)      17/50 (34%)      13/50 (26%)      11/60 (18%)                      |
|POLY-3 ADJUSTED (b)|        55.9%            40.1%            41.9%            28.9%            25.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        7/12 (58%)       5/16 (31%)       10/21 (48%)      8/31 (26%)       5/27 (19%)                       |
|FIRST INCIDENCE    |        396              507              527              610              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.080N         P=0.019N*        P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.002N**       P=0.100N         P=0.132N         P=0.007N**       P=0.003N**                       |
|POLY 1.5           |        P=0.003N**       P=0.109N         P=0.145N         P=0.014N*        P=0.004N**                       |
|POLY 6             |        P<0.001N**       P=0.101N         P=0.138N         P=0.003N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.115N         P=0.113N         P=0.011N*        P=0.002N**                       |
|COCH-ARM / FISHERS |        P=0.005N**       P=0.252N         P=0.327N         P=0.089N         P=0.008N**                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      3/50 (6%)        2/50 (4%)        4/50 (8%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        23.1%            7.0%             4.7%             9.7%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/28 (18%)       2/33 (6%)        2/34 (6%)        2/28 (7%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        461              700              738 (T)          586              652                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.019N*        P=0.026N*        P=0.010N*        P=0.086N         P=0.018N*                        |
|POLY 3             |        P=0.022N*        P=0.034N*        P=0.013N*        P=0.082N         P=0.013N*                        |
|POLY 1.5           |        P=0.021N*        P=0.040N*        P=0.015N*        P=0.086N         P=0.014N*                        |
|POLY 6             |        P=0.024N*        P=0.030N*        P=0.012N*        P=0.088N         P=0.013N*                        |
|LOGISTIC REGRESSION|        P=0.016N*        P=0.044N*        P=0.018N*        P=0.096N         P=0.015N*                        |
|COCH-ARM / FISHERS |        P=0.017N*        P=0.074N         P=0.032N*        P=0.142N         P=0.015N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 65
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        12/60 (20%)      9/50 (18%)       8/50 (16%)       7/50 (14%)       5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        28.7%            23.0%            20.0%            15.6%            11.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        2/16 (13%)       4/21 (19%)       3/31 (10%)       1/27 (4%)                        |
|FIRST INCIDENCE    |        396              450              527              544              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.004N**       P=0.338N         P=0.144N         P=0.032N*        P=0.017N*                        |
|POLY 3             |        P=0.024N*        P=0.369N         P=0.252N         P=0.110N         P=0.044N*                        |
|POLY 1.5           |        P=0.031N*        P=0.369N         P=0.261N         P=0.143N         P=0.049N*                        |
|POLY 6             |        P=0.016N*        P=0.387N         P=0.259N         P=0.082N         P=0.035N*                        |
|LOGISTIC REGRESSION|        P=0.031N*        P=0.446N         P=0.312N         P=0.229N         P=0.048N*                        |
|COCH-ARM / FISHERS |        P=0.035N*        P=0.493N         P=0.387N         P=0.284N         P=0.057N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        3/50 (6%)        0/50 (0%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        7.2%             7.0%             0.0%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        2/33 (6%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        543              700              ---              571              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.032N*        P=0.598N         P=0.101N         P=0.298N         P=0.125N                         |
|POLY 3             |        P=0.032N*        P=0.651N         P=0.114N         P=0.310N         P=0.115N                         |
|POLY 1.5           |        P=0.032N*        P=0.654          P=0.121N         P=0.316N         P=0.118N                         |
|POLY 6             |        P=0.032N*        P=0.632N         P=0.110N         P=0.313N         P=0.112N                         |
|LOGISTIC REGRESSION|        P=0.032N*        P=0.662          P=0.130N         P=0.357N         P=0.118N                         |
|COCH-ARM / FISHERS |        P=0.034N*        P=0.570          P=0.159N         P=0.381N         P=0.122N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 66
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        6/50 (12%)       4/50 (8%)        8/50 (16%)       9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        11.7%            13.8%            9.2%             18.8%            19.8%                            |
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)                       |
|TERMINAL (d)       |        3/28 (11%)       5/33 (15%)       2/34 (6%)        5/28 (18%)       4/28 (14%)                       |
|FIRST INCIDENCE    |        184 (I)          535              647              444              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.118          P=0.456          P=0.551N         P=0.194          P=0.214                          |
|POLY 3             |        P=0.123          P=0.510          P=0.492N         P=0.269          P=0.226                          |
|POLY 1.5           |        P=0.120          P=0.479          P=0.516N         P=0.255          P=0.211                          |
|POLY 6             |        P=0.123          P=0.541          P=0.473N         P=0.268          P=0.242                          |
|LOGISTIC REGRESSION|        P=0.127          P=0.405          P=0.602N         P=0.166          P=0.197                          |
|COCH-ARM / FISHERS |        P=0.126          P=0.373          P=0.615N         P=0.173          P=0.197                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 67
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        14/60 (23%)      27/50 (54%)      16/50 (32%)      27/48 (56%)      19/60 (32%)                      |
|POLY-3 ADJUSTED (b)|        33.9%            62.4%            41.5%            61.2%            43.1%                            |
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       7/16 (44%)       13/21 (62%)      18/30 (60%)      12/27 (44%)                      |
|FIRST INCIDENCE    |        184 (I)          428              666              605              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.040N*        P=0.014 *        P=0.479N         P=0.390          P=0.323N                         |
|POLY 3             |        P=0.424          P=0.005 **       P=0.315          P=0.007 **       P=0.252                          |
|POLY 1.5           |        P=0.334          P=0.003 **       P=0.315          P=0.003 **       P=0.208                          |
|POLY 6             |        P=0.470N         P=0.009 **       P=0.285          P=0.022 *        P=0.342                          |
|LOGISTIC REGRESSION|        P=0.458          P=0.002 **       P=0.405          P=0.005 **       P=0.260                          |
|COCH-ARM / FISHERS |        P=0.345          P<0.001 **       P=0.211          P<0.001 **       P=0.207                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        11/60 (18%)      14/49 (29%)      14/50 (28%)      9/50 (18%)       13/60 (22%)                      |
|POLY-3 ADJUSTED (b)|        25.4%            32.8%            31.9%            21.6%            29.4%                            |
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/28 (21%)       12/33 (36%)      12/34 (35%)      6/28 (21%)       8/28 (29%)                       |
|FIRST INCIDENCE    |        184 (I)          535              544              605              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.483          P=0.391          P=0.412          P=0.512N         P=0.439                          |
|POLY 3             |        P=0.480N         P=0.302          P=0.330          P=0.435N         P=0.427                          |
|POLY 1.5           |        P=0.486N         P=0.263          P=0.294          P=0.448N         P=0.405                          |
|POLY 6             |        P=0.485N         P=0.340          P=0.355          P=0.448N         P=0.449                          |
|LOGISTIC REGRESSION|        P=0.502N         P=0.279          P=0.306          P=0.459N         P=0.428                          |
|COCH-ARM / FISHERS |        P=0.473N         P=0.150          P=0.164          P=0.582N         P=0.410                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 68
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        0/48 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.1%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/30 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        184 (I)          ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.123N         P=1.000N         P=1.000N         P=1.000N         P=0.234N                         |
|POLY 3             |        P=0.083N         P=0.256N         P=0.244N         P=0.226N         P=0.224N                         |
|POLY 1.5           |        P=0.085N         P=0.256N         P=0.249N         P=0.243N         P=0.234N                         |
|POLY 6             |        P=0.083N         P=0.259N         P=0.240N         P=0.206N         P=0.207N                         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.088N         P=0.295N         P=0.295N         P=0.306N         P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/49 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 69
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/50 (18%)       3/45 (7%)        0/47 (0%)        0/46 (0%)        7/56 (13%)                       |
|POLY-3 ADJUSTED (b)|        24.7%            9.1%             0.0%             0.0%             17.2%                            |
|INT SACRIFICE 1 (c)|        0/3 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)                         |
|TERMINAL (d)       |        3/12 (25%)       1/14 (7%)        0/20 (0%)        0/28 (0%)        1/26 (4%)                        |
|FIRST INCIDENCE    |        681              544              ---              ---              680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.112N         P=0.059N         P<0.001N**       P<0.001N**       P=0.110N                         |
|POLY 3             |        P=0.231N         P=0.076N         P<0.001N**       P<0.001N**       P=0.295N                         |
|POLY 1.5           |        P=0.250N         P=0.074N         P=0.002N**       P<0.001N**       P=0.327N                         |
|POLY 6             |        P=0.207N         P=0.082N         P<0.001N**       P<0.001N**       P=0.237N                         |
|LOGISTIC REGRESSION|        P=0.233N         P=0.084N         P=0.002N**       P<0.001N**       P=0.252N                         |
|COCH-ARM / FISHERS |        P=0.279N         P=0.087N         P=0.002N**       P=0.002N**       P=0.302N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/54 (2%)        0/44 (0%)        0/41 (0%)        0/47 (0%)        1/53 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%             0.0%             2.6%                             |
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/8 (0%)                         |
|TERMINAL (d)       |        0/25 (0%)        0/29 (0%)        0/26 (0%)        0/26 (0%)        0/26 (0%)                        |
|FIRST INCIDENCE    |        704              ---              ---              ---              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.561          P=0.471N         P=0.477N         P=0.513N         P=0.743N                         |
|POLY 3             |        P=0.541          P=0.499N         P=0.519N         P=0.500N         P=0.758N                         |
|POLY 1.5           |        P=0.547          P=0.509N         P=0.525N         P=0.502N         P=0.759                          |
|POLY 6             |        P=0.535          P=0.489N         P=0.514N         P=0.502N         P=0.751N                         |
|LOGISTIC REGRESSION|        P=0.568          P=0.504N         P=0.521N         P=0.501N         P=0.759N                         |
|COCH-ARM / FISHERS |        P=0.571          P=0.551N         P=0.568N         P=0.535N         P=0.748                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 70
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       8/50 (16%)       3/49 (6%)        6/50 (12%)       6/60 (10%)                       |
|POLY-3 ADJUSTED (b)|        18.2%            21.7%            7.8%             13.5%            14.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/12 (25%)       6/16 (38%)       1/21 (5%)        3/31 (10%)       4/27 (15%)                       |
|FIRST INCIDENCE    |        579              563              583              614              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.062N         P=0.587N         P=0.080N         P=0.117N         P=0.137N                         |
|POLY 3             |        P=0.262N         P=0.463          P=0.150N         P=0.387N         P=0.423N                         |
|POLY 1.5           |        P=0.305N         P=0.456          P=0.169N         P=0.459N         P=0.463N                         |
|POLY 6             |        P=0.204N         P=0.454          P=0.136N         P=0.310N         P=0.360N                         |
|LOGISTIC REGRESSION|        P=0.236N         P=0.465          P=0.157N         P=0.392N         P=0.369N                         |
|COCH-ARM / FISHERS |        P=0.345N         P=0.350          P=0.256N         P=0.593          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        36/60 (60%)      28/50 (56%)      34/50 (68%)      32/50 (64%)      24/60 (40%)                      |
|POLY-3 ADJUSTED (b)|        76.3%            61.5%            75.4%            68.9%            52.3%                            |
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        23/28 (82%)      19/33 (58%)      27/34 (79%)      19/28 (68%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        184 (I)          392              563              444              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.086N         P=0.040N*        P=0.151N         P=0.385N         P=0.027N*                        |
|POLY 3             |        P=0.027N*        P=0.085N         P=0.562N         P=0.277N         P=0.010N*                        |
|POLY 1.5           |        P=0.030N*        P=0.122N         P=0.592          P=0.344N         P=0.013N*                        |
|POLY 6             |        P=0.026N*        P=0.064N         P=0.572N         P=0.265N         P=0.008N**                       |
|LOGISTIC REGRESSION|        P=0.021N*        P=0.101N         P=0.393N         P=0.382N         P=0.011N*                        |
|COCH-ARM / FISHERS |        P=0.022N*        P=0.409N         P=0.252          P=0.409          P=0.022N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 71
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        22/60 (37%)      13/50 (26%)      15/49 (31%)      21/50 (42%)      27/60 (45%)                      |
|POLY-3 ADJUSTED (b)|        53.6%            33.2%            36.0%            45.9%            59.8%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        6/12 (50%)       3/16 (19%)       8/21 (38%)       13/31 (42%)      17/27 (63%)                      |
|FIRST INCIDENCE    |        593              534              360              544              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.337N         P=0.054N         P=0.029N*        P=0.010N*        P=0.124N                         |
|POLY 3             |        P=0.075          P=0.044N*        P=0.074N         P=0.306N         P=0.351                          |
|POLY 1.5           |        P=0.055          P=0.054N         P=0.106N         P=0.435N         P=0.284                          |
|POLY 6             |        P=0.125          P=0.044N*        P=0.061N         P=0.205N         P=0.454                          |
|LOGISTIC REGRESSION|        P=0.086          P=0.060N         P=0.127N         P=0.266N         P=0.353                          |
|COCH-ARM / FISHERS |        P=0.059          P=0.161N         P=0.323N         P=0.354          P=0.229                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/60 (40%)      21/50 (42%)      26/50 (52%)      27/50 (54%)      24/60 (40%)                      |
|POLY-3 ADJUSTED (b)|        53.7%            47.5%            56.8%            58.7%            52.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        16/28 (57%)      15/33 (46%)      19/34 (56%)      16/28 (57%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        475              620              451              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.299          P=0.172N         P=0.442N         P=0.356          P=0.524N                         |
|POLY 3             |        P=0.403          P=0.354N         P=0.465          P=0.390          P=0.541N                         |
|POLY 1.5           |        P=0.389          P=0.410N         P=0.393          P=0.329          P=0.571N                         |
|POLY 6             |        P=0.410          P=0.305N         P=0.515          P=0.406          P=0.506N                         |
|LOGISTIC REGRESSION|        P=0.395          P=0.323N         P=0.422          P=0.257          P=0.536N                         |
|COCH-ARM / FISHERS |        P=0.449          P=0.493          P=0.143          P=0.101          P=0.574N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 72
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        3/49 (6%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             7.7%             2.3%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              708              572              736 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.376N         P=0.520          P=0.127          P=0.689          (e)                              |
|POLY 3             |        P=0.410N         P=0.493          P=0.124          P=0.529          (e)                              |
|POLY 1.5           |        P=0.447N         P=0.490          P=0.115          P=0.510          (e)                              |
|POLY 6             |        P=0.356N         P=0.493          P=0.134          P=0.551          (e)                              |
|LOGISTIC REGRESSION|        P=0.477N         P=0.493          P=0.086          P=0.689          (e)                              |
|COCH-ARM / FISHERS |        P=0.488N         P=0.455          P=0.088          P=0.455          (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             4.7%             0.0%             2.5%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        2/33 (6%)        0/34 (0%)        1/28 (4%)        2/28 (7%)                        |
|FIRST INCIDENCE    |        698              738 (T)          ---              738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.398          P=0.557          P=0.489N         P=0.747          P=0.510                          |
|POLY 3             |        P=0.441          P=0.511          P=0.493N         P=0.758          P=0.511                          |
|POLY 1.5           |        P=0.438          P=0.495          P=0.501N         P=0.754          P=0.504                          |
|POLY 6             |        P=0.441          P=0.526          P=0.487N         P=0.755          P=0.517                          |
|LOGISTIC REGRESSION|        P=0.417          P=0.531          P=0.500N         P=0.757          P=0.520                          |
|COCH-ARM / FISHERS |        P=0.439          P=0.431          P=0.545N         P=0.705          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 73
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/60 (12%)       7/50 (14%)       7/50 (14%)       4/50 (8%)        8/59 (14%)                       |
|POLY-3 ADJUSTED (b)|        18.1%            18.5%            17.9%            9.1%             19.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       3/16 (19%)       4/21 (19%)       3/31 (10%)       6/27 (22%)                       |
|FIRST INCIDENCE    |        396              435              572              660              613                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.123N         P=0.497N         P=0.337N         P=0.022N*        P=0.211N                         |
|POLY 3             |        P=0.444N         P=0.603          P=0.605N         P=0.192N         P=0.560                          |
|POLY 1.5           |        P=0.495N         P=0.584          P=0.598          P=0.238N         P=0.518                          |
|POLY 6             |        P=0.367N         P=0.617          P=0.580N         P=0.145N         P=0.595N                         |
|LOGISTIC REGRESSION|        P=0.457N         P=0.563          P=0.608N         P=0.193N         P=0.598                          |
|COCH-ARM / FISHERS |        P=0.541          P=0.466          P=0.466          P=0.378N         P=0.486                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 74
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        52/60 (87%)      40/50 (80%)      47/50 (94%)      47/50 (94%)      54/59 (92%)                      |
|POLY-3 ADJUSTED (b)|        93.5%            86.0%            96.8%            97.0%            95.5%                            |
|INT SACRIFICE 1 (c)|        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)                     |
|TERMINAL (d)       |        12/12 (100%)     13/16 (81%)      20/21 (95%)      30/31 (97%)      26/27 (96%)                      |
|FIRST INCIDENCE    |        184 (I)          410              443              518              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.306N         P=0.279N         P<0.001N**       P=0.004N**                       |
|POLY 3             |        P=0.104          P=0.139N         P=0.337          P=0.319          P=0.469                          |
|POLY 1.5           |        P=0.068          P=0.184N         P=0.222          P=0.197          P=0.344                          |
|POLY 6             |        P=0.211          P=0.087N         P=0.638          P=0.637          P=0.731                          |
|LOGISTIC REGRESSION|        P=0.081          P=0.204N         P=0.262          P=0.350          P=0.297                          |
|COCH-ARM / FISHERS |        P=0.074          P=0.247N         P=0.170          P=0.170          P=0.290                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 75
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/59 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.2%             0.0%             5.2%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        561              ---              666              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.072N         P=0.238N         P=0.608N         P=0.152N         P=0.172N                         |
|POLY 3             |        P=0.119N         P=0.248N         P=0.692N         P=0.210N         P=0.221N                         |
|POLY 1.5           |        P=0.130N         P=0.249N         P=0.687          P=0.228N         P=0.232N                         |
|POLY 6             |        P=0.105N         P=0.250N         P=0.685N         P=0.191N         P=0.205N                         |
|LOGISTIC REGRESSION|        P=0.124N         P=0.257N         P=0.690          P=0.251N         P=0.232N                         |
|COCH-ARM / FISHERS |        P=0.139N         P=0.295N         P=0.619          P=0.295N         P=0.252N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 76
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        43/60 (72%)      34/50 (68%)      32/50 (64%)      26/49 (53%)      44/60 (73%)                      |
|POLY-3 ADJUSTED (b)|        81.0%            73.1%            67.9%            54.9%            82.3%                            |
|INT SACRIFICE 1 (c)|        5/10 (50%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         7/10 (70%)                       |
|TERMINAL (d)       |        8/12 (67%)       10/16 (63%)      10/21 (48%)      15/30 (50%)      24/27 (89%)                      |
|FIRST INCIDENCE    |        184 (I)          410              360              213              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.260N         P=0.072N         P<0.001N**       P=0.019N*                        |
|POLY 3             |        P=0.455N         P=0.227N         P=0.088N         P=0.003N**       P=0.537                          |
|POLY 1.5           |        P=0.468N         P=0.230N         P=0.101N         P=0.005N**       P=0.545                          |
|POLY 6             |        P=0.432N         P=0.257N         P=0.090N         P=0.002N**       P=0.527                          |
|LOGISTIC REGRESSION|        P=0.502N         P=0.393N         P=0.253N         P=0.043N*        P=0.523                          |
|COCH-ARM / FISHERS |        P=0.493N         P=0.416N         P=0.256N         P=0.036N*        P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 77
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             0.0%             4.6%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          ---              707              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.224          P=0.557          (e)              P=0.428          P=0.429                          |
|POLY 3             |        P=0.119          P=0.492          (e)              P=0.273          P=0.261                          |
|POLY 1.5           |        P=0.109          P=0.490          (e)              P=0.250          P=0.249                          |
|POLY 6             |        P=0.140          P=0.491          (e)              P=0.303          P=0.283                          |
|LOGISTIC REGRESSION|        P=0.177          P=0.557          (e)              P=0.318          P=0.429                          |
|COCH-ARM / FISHERS |        P=0.109          P=0.455          (e)              P=0.204          P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.134          (e)              (e)              (e)              P=0.500                          |
|POLY 3             |        P=0.151          (e)              (e)              (e)              P=0.507                          |
|POLY 1.5           |        P=0.152          (e)              (e)              (e)              P=0.502                          |
|POLY 6             |        P=0.151          (e)              (e)              (e)              P=0.511                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500                          |
|COCH-ARM / FISHERS |        P=0.160          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 78
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        3/50 (6%)        3/50 (6%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             7.9%             6.9%             9.6%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        3/21 (14%)       3/31 (10%)       3/27 (11%)                       |
|FIRST INCIDENCE    |        ---              726              736 (T)          736 (T)          715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.135          P=0.525          P=0.232          P=0.328          P=0.186                          |
|POLY 3             |        P=0.046 *        P=0.492          P=0.120          P=0.149          P=0.075                          |
|POLY 1.5           |        P=0.038 *        P=0.490          P=0.115          P=0.129          P=0.067                          |
|POLY 6             |        P=0.065          P=0.492          P=0.124          P=0.175          P=0.089                          |
|LOGISTIC REGRESSION|        P=0.097          P=0.506          P=0.232          P=0.328          P=0.132                          |
|COCH-ARM / FISHERS |        P=0.035 *        P=0.455          P=0.091          P=0.091          P=0.059                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 79
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        663              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.210N         P=0.521N         P=0.507N         P=0.448N         P=0.448N                         |
|POLY 3             |        P=0.245N         P=0.509N         P=0.498N         P=0.472N         P=0.480N                         |
|POLY 1.5           |        P=0.244N         P=0.511N         P=0.504N         P=0.490N         P=0.490N                         |
|POLY 6             |        P=0.250N         P=0.512N         P=0.494N         P=0.452N         P=0.463N                         |
|LOGISTIC REGRESSION|        P=0.238N         P=0.514N         P=0.509N         P=0.508N         P=0.487N                         |
|COCH-ARM / FISHERS |        P=0.247N         P=0.545N         P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             4.6%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        1/34 (3%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              600              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.299N         P=0.467N         P=0.553          P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.301N         P=0.493N         P=0.518          P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.297N         P=0.503N         P=0.501          P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.310N         P=0.483N         P=0.532          P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.294N         (e)              P=0.494          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.295N         P=0.545N         P=0.431          P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 80
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        3/50 (6%)        3/50 (6%)        1/50 (2%)        6/60 (10%)                       |
|POLY-3 ADJUSTED (b)|        13.2%            8.3%             7.8%             2.3%             14.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       2/16 (13%)       2/21 (10%)       1/31 (3%)        6/27 (22%)                       |
|FIRST INCIDENCE    |        603              723              645              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.259N         P=0.231N         P=0.158N         P=0.007N**       P=0.244N                         |
|POLY 3             |        P=0.511          P=0.381N         P=0.347N         P=0.073N         P=0.567                          |
|POLY 1.5           |        P=0.477          P=0.386N         P=0.366N         P=0.091N         P=0.532                          |
|POLY 6             |        P=0.548N         P=0.386N         P=0.332N         P=0.057N         P=0.625                          |
|LOGISTIC REGRESSION|        P=0.447N         P=0.361N         P=0.324N         P=0.046N*        P=0.515N                         |
|COCH-ARM / FISHERS |        P=0.446          P=0.464N         P=0.464N         P=0.151N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        696              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.250N         P=0.473N         P=0.494N         P=0.531N         P=0.489N                         |
|POLY 3             |        P=0.258N         P=0.494N         P=0.493N         P=0.503N         P=0.494N                         |
|POLY 1.5           |        P=0.251N         P=0.503N         P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.269N         P=0.485N         P=0.487N         P=0.506N         P=0.490N                         |
|LOGISTIC REGRESSION|        P=0.243N         P=0.502N         P=0.501N         P=0.507N         P=0.494N                         |
|COCH-ARM / FISHERS |        P=0.247N         P=0.545N         P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 81
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/60 (7%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        10.3%            0.0%             2.6%             0.0%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        396              ---              593              ---              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.393N         P=0.058N         P=0.138N         P=0.023N*        P=0.327N                         |
|POLY 3             |        P=0.493N         P=0.068N         P=0.178N         P=0.047N*        P=0.451N                         |
|POLY 1.5           |        P=0.509N         P=0.068N         P=0.187N         P=0.056N         P=0.478N                         |
|POLY 6             |        P=0.474N         P=0.070N         P=0.171N         P=0.039N*        P=0.404N                         |
|LOGISTIC REGRESSION|        P=0.517N         P=0.081N         P=0.233N         P=0.081N         P=0.480N                         |
|COCH-ARM / FISHERS |        P=0.518N         P=0.084N         P=0.244N         P=0.084N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/60 (15%)       12/50 (24%)      6/50 (12%)       10/50 (20%)      7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        21.0%            27.6%            13.6%            23.3%            15.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/28 (18%)       10/33 (30%)      3/34 (9%)        6/28 (21%)       0/28 (0%)                        |
|FIRST INCIDENCE    |        391              535              399              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.300N         P=0.450          P=0.200N         P=0.499          P=0.378N                         |
|POLY 3             |        P=0.214N         P=0.324          P=0.263N         P=0.505          P=0.343N                         |
|POLY 1.5           |        P=0.230N         P=0.287          P=0.293N         P=0.481          P=0.370N                         |
|POLY 6             |        P=0.200N         P=0.362          P=0.243N         P=0.502          P=0.313N                         |
|LOGISTIC REGRESSION|        P=0.245N         P=0.309          P=0.339N         P=0.412          P=0.388N                         |
|COCH-ARM / FISHERS |        P=0.237N         P=0.170          P=0.432N         P=0.330          P=0.395N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 82
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        2/50 (4%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             5.2%             4.6%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        690              ---              617              709              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.163N         P=0.229N         P=0.631N         P=0.435N         P=0.139N                         |
|POLY 3             |        P=0.278N         P=0.246N         P=0.686N         P=0.640N         P=0.215N                         |
|POLY 1.5           |        P=0.299N         P=0.248N         P=0.690          P=0.675N         P=0.226N                         |
|POLY 6             |        P=0.241N         P=0.247N         P=0.675N         P=0.598N         P=0.197N                         |
|LOGISTIC REGRESSION|        P=0.243N         P=0.243N         P=0.692N         P=0.581N         P=0.187N                         |
|COCH-ARM / FISHERS |        P=0.295N         P=0.295N         P=0.619          P=0.619          P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        573              ---              ---              634              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.425N         P=0.495N         P=0.491N         P=0.759N         P=0.486N                         |
|POLY 3             |        P=0.461N         P=0.495N         P=0.494N         P=0.758          P=0.496N                         |
|POLY 1.5           |        P=0.455N         P=0.504N         P=0.502N         P=0.754          P=0.499N                         |
|POLY 6             |        P=0.468N         P=0.488N         P=0.489N         P=0.755          P=0.493N                         |
|LOGISTIC REGRESSION|        P=0.426N         P=0.580N         P=0.591N         P=0.707          P=0.500N                         |
|COCH-ARM / FISHERS |        P=0.430N         P=0.545N         P=0.545N         P=0.705          P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 83
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      4/50 (8%)        3/50 (6%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        25.5%            10.7%            7.6%             4.5%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        579              544              360              561              265                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.084N         P=0.028N*        P=0.002N**       P=0.004N**                       |
|POLY 3             |        P=0.004N**       P=0.080N         P=0.029N*        P=0.007N**       P=0.008N**                       |
|POLY 1.5           |        P=0.005N**       P=0.085N         P=0.035N*        P=0.011N*        P=0.010N*                        |
|POLY 6             |        P=0.002N**       P=0.081N         P=0.026N*        P=0.004N**       P=0.005N**                       |
|LOGISTIC REGRESSION|        P=0.006N**       P=0.090N         P=0.046N*        P=0.011N*        P=0.012N*                        |
|COCH-ARM / FISHERS |        P=0.006N**       P=0.142N         P=0.074N         P=0.032N*        P=0.015N*                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        3/50 (6%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             6.8%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        731              ---              451              684              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.399N         P=0.468N         P=0.335          P=0.750          P=0.507N                         |
|POLY 3             |        P=0.408N         P=0.493N         P=0.331          P=0.759          P=0.493N                         |
|POLY 1.5           |        P=0.406N         P=0.503N         P=0.310          P=0.755          P=0.498N                         |
|POLY 6             |        P=0.414N         P=0.484N         P=0.350          P=0.758          P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.388N         P=0.475N         P=0.212          P=0.757          P=0.489N                         |
|COCH-ARM / FISHERS |        P=0.390N         P=0.545N         P=0.244          P=0.705          P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 84
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/60 (13%)       8/50 (16%)       4/50 (8%)        3/50 (6%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        20.4%            21.1%            9.9%             6.8%             9.2%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        2/16 (13%)       0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        579              544              360              561              265                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.014N*        P=0.579N         P=0.156N         P=0.022N*        P=0.074N                         |
|POLY 3             |        P=0.031N*        P=0.583          P=0.158N         P=0.064N         P=0.125N                         |
|POLY 1.5           |        P=0.040N*        P=0.570          P=0.178N         P=0.086N         P=0.147N                         |
|POLY 6             |        P=0.022N*        P=0.584          P=0.147N         P=0.047N*        P=0.100N                         |
|LOGISTIC REGRESSION|        P=0.057N         P=0.561          P=0.241N         P=0.087N         P=0.169N                         |
|COCH-ARM / FISHERS |        P=0.056N         P=0.449          P=0.281N         P=0.170N         P=0.181N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        1/50 (2%)        3/50 (6%)        3/50 (6%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        7.1%             2.3%             6.8%             7.2%             9.2%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        543              620              451              605              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.257          P=0.280N         P=0.625N         P=0.644          P=0.520                          |
|POLY 3             |        P=0.244          P=0.295N         P=0.637N         P=0.660          P=0.521                          |
|POLY 1.5           |        P=0.248          P=0.311N         P=0.660N         P=0.650          P=0.508                          |
|POLY 6             |        P=0.238          P=0.281N         P=0.619N         P=0.659          P=0.532                          |
|LOGISTIC REGRESSION|        P=0.280          P=0.355N         P=0.550          P=0.602          P=0.505                          |
|COCH-ARM / FISHERS |        P=0.276          P=0.381N         P=0.570          P=0.570          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 85
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia Basal Cell                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.2%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        2/21 (10%)       0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              736 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.441N         (e)              P=0.367          (e)              (e)                              |
|POLY 3             |        P=0.522N         (e)              P=0.240          (e)              (e)                              |
|POLY 1.5           |        P=0.549N         (e)              P=0.233          (e)              (e)                              |
|POLY 6             |        P=0.487N         (e)              P=0.246          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.367          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.587N         (e)              P=0.204          (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia Basal Cell                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 86
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/60 (13%)       3/50 (6%)        4/50 (8%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        20.7%            8.1%             10.0%            2.3%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        600              544              527              561              715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.101N         P=0.138N         P=0.003N**       P=0.003N**                       |
|POLY 3             |        P=0.004N**       P=0.105N         P=0.155N         P=0.009N**       P=0.010N*                        |
|POLY 1.5           |        P=0.005N**       P=0.111N         P=0.177N         P=0.013N*        P=0.013N*                        |
|POLY 6             |        P=0.002N**       P=0.104N         P=0.137N         P=0.005N**       P=0.007N**                       |
|LOGISTIC REGRESSION|        P=0.005N**       P=0.115N         P=0.196N         P=0.011N*        P=0.009N**                       |
|COCH-ARM / FISHERS |        P=0.006N**       P=0.170N         P=0.281N         P=0.031N*        P=0.016N*                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        3/50 (6%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             6.8%             2.4%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        475              ---              451              684              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.225N         P=0.227N         P=0.525          P=0.513N         P=0.246N                         |
|POLY 3             |        P=0.245N         P=0.233N         P=0.525          P=0.509N         P=0.233N                         |
|POLY 1.5           |        P=0.240N         P=0.242N         P=0.502          P=0.513N         P=0.237N                         |
|POLY 6             |        P=0.254N         P=0.225N         P=0.544          P=0.514N         P=0.230N                         |
|LOGISTIC REGRESSION|        P=0.219N         P=0.294N         P=0.336          P=0.571N         P=0.238N                         |
|COCH-ARM / FISHERS |        P=0.221N         P=0.295N         P=0.414          P=0.569N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 87
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             0.0%             0.0%             2.3%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        715              ---              ---              736 (T)          684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.305          P=0.490N         P=0.462N         P=0.591N         P=0.670                          |
|POLY 3             |        P=0.191          P=0.508N         P=0.497N         P=0.726N         P=0.538                          |
|POLY 1.5           |        P=0.182          P=0.510N         P=0.504N         P=0.749N         P=0.518                          |
|POLY 6             |        P=0.210          P=0.510N         P=0.493N         P=0.699N         P=0.570                          |
|LOGISTIC REGRESSION|        P=0.240          P=0.504N         P=0.483N         P=0.666N         P=0.577                          |
|COCH-ARM / FISHERS |        P=0.191          P=0.545N         P=0.545N         P=0.705          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 88
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             2.7%             0.0%             4.5%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        603              614              ---              518              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.341N         P=0.480N         P=0.180N         P=0.498N         P=0.343N                         |
|POLY 3             |        P=0.456N         P=0.514N         P=0.235N         P=0.638N         P=0.466N                         |
|POLY 1.5           |        P=0.471N         P=0.517N         P=0.242N         P=0.674N         P=0.484N                         |
|POLY 6             |        P=0.429N         P=0.515N         P=0.231N         P=0.596N         P=0.437N                         |
|LOGISTIC REGRESSION|        P=0.462N         P=0.531N         P=0.242N         P=0.665          P=0.466N                         |
|COCH-ARM / FISHERS |        P=0.469N         P=0.569N         P=0.295N         P=0.619          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        2/50 (4%)        1/50 (2%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             4.6%             2.3%             4.8%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        696              620              733              572              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.303N         P=0.542          P=0.733N         P=0.480          P=0.489N                         |
|POLY 3             |        P=0.294N         P=0.516          P=0.752N         P=0.502          P=0.494N                         |
|POLY 1.5           |        P=0.298N         P=0.497          P=0.760          P=0.493          P=0.498N                         |
|POLY 6             |        P=0.294N         P=0.534          P=0.745N         P=0.502          P=0.490N                         |
|LOGISTIC REGRESSION|        P=0.296N         P=0.470          P=0.753N         P=0.436          P=0.494N                         |
|COCH-ARM / FISHERS |        P=0.295N         P=0.431          P=0.705          P=0.431          P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 89
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        2/50 (4%)        4/50 (8%)        4/50 (8%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             5.3%             10.4%            9.1%             9.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        2/21 (10%)       2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        733              507              702              621              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.443          P=0.663N         P=0.537          P=0.655N         P=0.550                          |
|POLY 3             |        P=0.272          P=0.694          P=0.346          P=0.414          P=0.401                          |
|POLY 1.5           |        P=0.234          P=0.684          P=0.329          P=0.365          P=0.368                          |
|POLY 6             |        P=0.345          P=0.692N         P=0.360          P=0.473          P=0.455                          |
|LOGISTIC REGRESSION|        P=0.233          P=0.649          P=0.406          P=0.456          P=0.372                          |
|COCH-ARM / FISHERS |        P=0.217          P=0.619          P=0.257          P=0.257          P=0.340                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 90
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/60 (17%)      10/50 (20%)      6/50 (12%)       5/50 (10%)       8/60 (13%)                       |
|POLY-3 ADJUSTED (b)|        24.6%            24.1%            14.6%            11.1%            17.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       0/16 (0%)        0/21 (0%)        1/31 (3%)        3/27 (11%)                       |
|FIRST INCIDENCE    |        435              435              360              518              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.090N         P=0.571          P=0.166N         P=0.033N*        P=0.166N                         |
|POLY 3             |        P=0.140N         P=0.585N         P=0.194N         P=0.086N         P=0.310N                         |
|POLY 1.5           |        P=0.167N         P=0.583          P=0.215N         P=0.115N         P=0.350N                         |
|POLY 6             |        P=0.108N         P=0.559N         P=0.183N         P=0.061N         P=0.257N                         |
|LOGISTIC REGRESSION|        P=0.212N         P=0.392          P=0.346N         P=0.201N         P=0.383N                         |
|COCH-ARM / FISHERS |        P=0.201N         P=0.418          P=0.340N         P=0.232N         P=0.399N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 91
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/59 (0%)        0/46 (0%)        0/49 (0%)        0/47 (0%)        0/58 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/15 (0%)        0/20 (0%)        0/28 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/58 (0%)        1/44 (2%)        3/48 (6%)        0/47 (0%)        0/59 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.5%             7.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/26 (0%)        0/31 (0%)        3/33 (9%)        0/27 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              392              738 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.409N         P=0.496          P=0.165          (e)              (e)                              |
|POLY 3             |        P=0.354N         P=0.500          P=0.128          (e)              (e)                              |
|POLY 1.5           |        P=0.362N         P=0.486          P=0.119          (e)              (e)                              |
|POLY 6             |        P=0.351N         P=0.514          P=0.137          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.391N         P=0.248          P=0.165          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.390N         P=0.431          P=0.090          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 92
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/59 (0%)        1/46 (2%)        0/49 (0%)        0/47 (0%)        0/58 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             3.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/15 (0%)        0/20 (0%)        0/28 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              708              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.376N         P=0.520          (e)              (e)              (e)                              |
|POLY 3             |        P=0.393N         P=0.476          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.401N         P=0.475          (e)              (e)              (e)                              |
|POLY 6             |        P=0.393N         P=0.474          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.421N         P=0.475          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.451N         P=0.438          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/58 (0%)        0/44 (0%)        0/48 (0%)        2/47 (4%)        0/59 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             5.1%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/26 (0%)        0/31 (0%)        0/33 (0%)        0/27 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              634              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.409          (e)              (e)              P=0.222          (e)                              |
|POLY 3             |        P=0.366          (e)              (e)              P=0.237          (e)                              |
|POLY 1.5           |        P=0.367          (e)              (e)              P=0.229          (e)                              |
|POLY 6             |        P=0.371          (e)              (e)              P=0.241          (e)                              |
|LOGISTIC REGRESSION|        P=0.423          (e)              (e)              P=0.188          (e)                              |
|COCH-ARM / FISHERS |        P=0.422          (e)              (e)              P=0.198          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 93
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        16/60 (27%)      8/50 (16%)       21/50 (42%)      19/50 (38%)      17/60 (28%)                      |
|POLY-3 ADJUSTED (b)|        39.7%            21.1%            50.5%            42.8%            38.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       3/16 (19%)       11/21 (52%)      16/31 (52%)      11/27 (41%)                      |
|FIRST INCIDENCE    |        579              507              521              619              360                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.152N         P=0.042N*        P=0.567N         P=0.049N*        P=0.105N                         |
|POLY 3             |        P=0.290          P=0.056N         P=0.215          P=0.471          P=0.541N                         |
|POLY 1.5           |        P=0.216          P=0.061N         P=0.181          P=0.370          P=0.573                          |
|POLY 6             |        P=0.431          P=0.060N         P=0.234          P=0.569          P=0.454N                         |
|LOGISTIC REGRESSION|        P=0.325          P=0.063N         P=0.206          P=0.547N         P=0.543N                         |
|COCH-ARM / FISHERS |        P=0.207          P=0.132N         P=0.068          P=0.143          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        16/60 (27%)      23/50 (46%)      27/50 (54%)      20/50 (40%)      17/60 (28%)                      |
|POLY-3 ADJUSTED (b)|        37.6%            51.6%            60.3%            47.1%            38.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        9/28 (32%)       19/33 (58%)      21/34 (62%)      15/28 (54%)      12/28 (43%)                      |
|FIRST INCIDENCE    |        620              430              544              572              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.501N         P=0.272          P=0.113          P=0.259          P=0.529                          |
|POLY 3             |        P=0.324N         P=0.132          P=0.024 *        P=0.249          P=0.564                          |
|POLY 1.5           |        P=0.339N         P=0.096          P=0.016 *        P=0.229          P=0.531                          |
|POLY 6             |        P=0.333N         P=0.164          P=0.032 *        P=0.233          P=0.586                          |
|LOGISTIC REGRESSION|        P=0.366N         P=0.130          P=0.029 *        P=0.232          P=0.555                          |
|COCH-ARM / FISHERS |        P=0.340N         P=0.028 *        P=0.003 **       P=0.100          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 94
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        0/50 (0%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%             4.9%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        2/33 (6%)        0/34 (0%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          ---              692              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.543N         P=0.275          (e)              P=0.226          (e)                              |
|POLY 3             |        P=0.494N         P=0.245          (e)              P=0.235          (e)                              |
|POLY 1.5           |        P=0.503N         P=0.234          (e)              P=0.231          (e)                              |
|POLY 6             |        P=0.486N         P=0.257          (e)              P=0.233          (e)                              |
|LOGISTIC REGRESSION|        P=0.524N         P=0.275          (e)              P=0.232          (e)                              |
|COCH-ARM / FISHERS |        P=0.512N         P=0.204          (e)              P=0.204          (e)                              |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.