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TDMS Study 89002-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Degeneration Fatty
                                       Hypertrophy
Adrenal Medulla                        Hyperplasia
Bone Marrow                            Hyperplasia
Heart                                  Cardiomyopathy Chronic
Heart: Atrium                          Thrombosis
Kidney                                 Nephropathy Chronic
Kidney: Renal Tubule                   Pigmentation
Liver                                  Basophilic Focus
                                       Clear Cell Focus
                                       Eosinophilic Focus
                                       Hepatodiaphragmatic Nodule
                                       Inflammation Chronic
Liver: Bile Duct                       Hyperplasia
Liver: Hepatocyte                      Degeneration Cystic
                                       Vacuolization Cytoplasmic
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lymph Node, Mediastinal                Pigmentation Hemosiderin
Mammary Gland                          Hyperplasia Cystic
Mesentery: Fat                         Necrosis
Nose                                   Fungus
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Hyperplasia
                                       Metaplasia
Pancreas: Acinus                       Atrophy
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Cyst
                                       Hyperplasia
Preputial Gland                        Hyperplasia
                                       Inflammation Chronic
Prostate                               Inflammation Chronic
Skin: Epidermis                        Hyperkeratosis
Spleen                                 Fibrosis
                                       Hematopoietic Cell Proliferation
Stomach, Forestomach                   Inflammation Chronic
Stomach, Forestomach: Epithelium       Hyperplasia
                                       Ulcer
Testes: Interstitial Cell              Hyperplasia
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       

-----                                  ----------
Adrenal Cortex                         Degeneration Fatty
                                       Hyperplasia
                                       Hypertrophy
Bone                                   Osteopetrosis
Bone Marrow                            Hyperplasia
Clitoral Gland                         Inflammation Chronic
Eye: Lens                              Cataract
Eye: Retina                            Atrophy
Heart                                  Cardiomyopathy Chronic
Intestine Large, Colon                 Parasite Metazoan
Intestine Large, Rectum                Parasite Metazoan
Liver                                  Clear Cell Focus
                                       Mixed Cell Focus
Liver: Hepatocyte                      Vacuolization Cytoplasmic
Lymph Node, Mediastinal                Pigmentation Hemosiderin
Nose                                   Fungus
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Hyperplasia
Pituitary Gland: Pars Distalis         Cyst
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         4.6%        |2.4%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    2/31 (7%)   |1/28 (4%)    2/33 (6%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          736 (T)      736 (T)     |738 (T)      738 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.161      (e)          P=0.612      P=0.463     |P=0.138N     P=0.558      P=0.461N     P=0.500N     |
|POLY 3             |     P=0.076      (e)          P=0.504      P=0.272     |P=0.148N     P=0.514      P=0.491N     P=0.502N     |
|POLY 1.5           |     P=0.068      (e)          P=0.502      P=0.256     |P=0.148N     P=0.505      P=0.495N     P=0.501N     |
|POLY 6             |     P=0.091      (e)          P=0.509      P=0.299     |P=0.150N     P=0.529      P=0.485N     P=0.505N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.612      P=0.463     |P=0.138N     P=0.558      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.059      (e)          P=0.500      P=0.247     |P=0.149N     P=0.500      P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    4/50 (8%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         2.8%         2.6%         0.0%        |0.0%         9.3%         7.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/16 (6%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    4/33 (12%)   3/34 (9%)    0/28 (0%)    |
|FIRST INCIDENCE    |     736 (T)      736 (T)      624          ---         |---          738 (T)      738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.168N     P=0.698N     P=0.704N     P=0.311N    |P=0.496N     P=0.085      P=0.157      (e)          |
|POLY 3             |     P=0.268N     P=0.754      P=0.755N     P=0.470N    |P=0.506N     P=0.065      P=0.126      (e)          |
|POLY 1.5           |     P=0.284N     P=0.756      P=0.757N     P=0.484N    |P=0.502N     P=0.062      P=0.123      (e)          |
|POLY 6             |     P=0.245N     P=0.753      P=0.748N     P=0.449N    |P=0.518N     P=0.071      P=0.132      (e)          |
|LOGISTIC REGRESSION|     P=0.259N     P=0.698N     P=0.759N     (e)         |(e)          P=0.085      P=0.157      (e)          |
|COCH-ARM / FISHERS |     P=0.301N     P=0.753N     P=0.753N     P=0.500N    |P=0.500N     P=0.059      P=0.121      (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  19/50 (38%)  16/50 (32%)  20/50 (40%) |9/50 (18%)   11/50 (22%)  17/50 (34%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     63.2%        46.9%        38.1%        43.5%       |21.2%        25.5%        37.7%        35.6%        |
|TERMINAL (d)       |     8/12 (67%)   6/16 (38%)   6/21 (29%)   12/31 (39%) |4/28 (14%)   10/33 (30%)  10/34 (29%)  11/28 (39%)  |
|FIRST INCIDENCE    |     396          507          443          518         |585          620          451          586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.064N     P=0.005N**   P<0.001N**  |P=0.049 *    P=0.545      P=0.139      P=0.122      |
|POLY 3             |     P=0.020N*    P=0.087N     P=0.012N*    P=0.041N*   |P=0.044 *    P=0.417      P=0.071      P=0.107      |
|POLY 1.5           |     P=0.030N*    P=0.072N     P=0.012N*    P=0.059N    |P=0.046 *    P=0.403      P=0.062      P=0.114      |
|POLY 6             |     P=0.011N*    P=0.100N     P=0.012N*    P=0.023N*   |P=0.038 *    P=0.441      P=0.084      P=0.096      |
|LOGISTIC REGRESSION|     P=0.037N*    P=0.058N     P=0.013N*    P=0.080N    |P=0.045 *    P=0.442      P=0.060      P=0.112      |
|COCH-ARM / FISHERS |     P=0.048N*    P=0.054N     P=0.013N*    P=0.080N    |P=0.049 *    P=0.402      P=0.055      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  13/50 (26%)  15/50 (30%) |7/50 (14%)   12/50 (24%)  23/50 (46%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     32.2%        29.3%        33.1%        34.0%       |17.0%        28.0%        51.6%        29.1%        |
|TERMINAL (d)       |     4/12 (33%)   7/16 (44%)   8/21 (38%)   12/31 (39%) |6/28 (21%)   12/33 (36%)  19/34 (56%)  10/28 (36%)  |
|FIRST INCIDENCE    |     564          524          605          619         |698          738 (T)      451          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.067N     P=0.313N     P=0.291N     P=0.088N    |P=0.027 *    P=0.255      P=0.003 **   P=0.141      |
|POLY 3             |     P=0.417      P=0.488N     P=0.562      P=0.521     |P=0.027 *    P=0.168      P<0.001 **   P=0.144      |
|POLY 1.5           |     P=0.363      P=0.450N     P=0.576      P=0.471     |P=0.031 *    P=0.156      P<0.001 **   P=0.149      |
|POLY 6             |     P=0.500      P=0.541N     P=0.544      P=0.590     |P=0.022 *    P=0.192      P<0.001 **   P=0.135      |
|LOGISTIC REGRESSION|     P=0.499N     P=0.441N     P=0.567N     P=0.582     |P=0.024 *    P=0.255      P<0.001 **   P=0.120      |
|COCH-ARM / FISHERS |     P=0.307      P=0.408N     P=0.590N     P=0.412     |P=0.037 *    P=0.154      P<0.001 **   P=0.154      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    6/50 (12%)   8/50 (16%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         5.1%         9.2%        |2.4%         14.0%        18.6%        17.2%        |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    4/31 (13%)  |1/28 (4%)    6/33 (18%)   8/34 (24%)   7/28 (25%)   |
|FIRST INCIDENCE    |     ---          619          443          736 (T)     |738 (T)      738 (T)      738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.068      P=0.489      P=0.244      P=0.238     |P=0.020 *    P=0.085      P=0.033 *    P=0.029 *    |
|POLY 3             |     P=0.028 *    P=0.495      P=0.249      P=0.082     |P=0.024 *    P=0.061      P=0.018 *    P=0.028 *    |
|POLY 1.5           |     P=0.024 *    P=0.497      P=0.244      P=0.071     |P=0.025 *    P=0.058      P=0.017 *    P=0.029 *    |
|POLY 6             |     P=0.038 *    P=0.496      P=0.258      P=0.100     |P=0.022 *    P=0.069      P=0.020 *    P=0.025 *    |
|LOGISTIC REGRESSION|     P=0.016 *    P=0.506      P=0.198      P=0.238     |P=0.020 *    P=0.085      P=0.033 *    P=0.029 *    |
|COCH-ARM / FISHERS |     P=0.019 *    P=0.500      P=0.247      P=0.059     |P=0.027 *    P=0.056      P=0.015 *    P=0.030 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  27/50 (54%)  22/50 (44%)  25/50 (50%) |3/50 (6%)    7/50 (14%)   6/50 (12%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     46.2%        65.0%        51.8%        53.9%       |7.3%         16.0%        13.6%        16.3%        |
|TERMINAL (d)       |     6/12 (50%)   9/16 (56%)   9/21 (43%)   17/31 (55%) |3/28 (11%)   5/33 (15%)   4/34 (12%)   2/28 (7%)    |
|FIRST INCIDENCE    |     647          563          521          544         |738 (T)      430          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.056N     P=0.167      P=0.477N     P=0.118N    |P=0.158      P=0.223      P=0.327      P=0.163      |
|POLY 3             |     P=0.456      P=0.056      P=0.383      P=0.307     |P=0.183      P=0.182      P=0.276      P=0.173      |
|POLY 1.5           |     P=0.303      P=0.050      P=0.325      P=0.199     |P=0.175      P=0.168      P=0.261      P=0.168      |
|POLY 6             |     P=0.386N     P=0.087      P=0.491      P=0.495     |P=0.191      P=0.205      P=0.296      P=0.180      |
|LOGISTIC REGRESSION|     P=0.377      P=0.024 *    P=0.288      P=0.334     |P=0.160      P=0.166      P=0.248      P=0.158      |
|COCH-ARM / FISHERS |     P=0.171      P=0.054      P=0.270      P=0.113     |P=0.161      P=0.159      P=0.243      P=0.159      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |6/50 (12%)   1/50 (2%)    4/50 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         0.0%         0.0%        |14.5%        2.3%         9.3%         4.9%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |3/28 (11%)   0/33 (0%)    4/34 (12%)   1/28 (4%)    |
|FIRST INCIDENCE    |     ---          614          ---          ---         |698          698          738 (T)      634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.474N     P=0.489      (e)          (e)         |P=0.157N     P=0.040N*    P=0.273N     P=0.154N     |
|POLY 3             |     P=0.497N     P=0.495      (e)          (e)         |P=0.157N     P=0.050N     P=0.347N     P=0.134N     |
|POLY 1.5           |     P=0.499N     P=0.497      (e)          (e)         |P=0.152N     P=0.054N     P=0.357N     P=0.133N     |
|POLY 6             |     P=0.490N     P=0.496      (e)          (e)         |P=0.168N     P=0.044N*    P=0.333N     P=0.139N     |
|LOGISTIC REGRESSION|     P=0.520N     P=0.507      (e)          (e)         |P=0.153N     P=0.049N*    P=0.312N     P=0.138N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.152N     P=0.056N     P=0.370N     P=0.134N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  33/50 (66%)  36/50 (72%)  32/50 (64%) |11/50 (22%)  14/50 (28%)  17/50 (34%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     67.6%        74.9%        77.7%        67.1%       |25.3%        31.4%        38.2%        45.1%        |
|TERMINAL (d)       |     5/12 (42%)   11/16 (69%)  16/21 (76%)  19/31 (61%) |3/28 (11%)   6/33 (18%)   12/34 (35%)  9/28 (32%)   |
|FIRST INCIDENCE    |     396          435          360          518         |475          535          535          444          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.013N*    P=0.477      P=0.505N     P=0.019N*   |P=0.023 *    P=0.474      P=0.273      P=0.046 *    |
|POLY 3             |     P=0.528N     P=0.291      P=0.188      P=0.569N    |P=0.020 *    P=0.346      P=0.140      P=0.037 *    |
|POLY 1.5           |     P=0.423      P=0.309      P=0.170      P=0.524     |P=0.018 *    P=0.326      P=0.135      P=0.032 *    |
|POLY 6             |     P=0.401N     P=0.280      P=0.206      P=0.475N    |P=0.022 *    P=0.383      P=0.146      P=0.042 *    |
|LOGISTIC REGRESSION|     P=0.385      P=0.304      P=0.151      P=0.504     |P=0.015 *    P=0.324      P=0.140      P=0.025 *    |
|COCH-ARM / FISHERS |     P=0.297      P=0.339      P=0.146      P=0.418     |P=0.015 *    P=0.322      P=0.133      P=0.026 *    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         5.5%         0.0%         2.3%        |2.4%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     684          698          ---          708         |705          698          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.516      P=0.500N     P=0.645N    |P=0.176N     P=0.722N     P=0.470N     P=0.513N     |
|POLY 3             |     P=0.390N     P=0.488      P=0.497N     P=0.726N    |P=0.174N     P=0.752N     P=0.492N     P=0.502N     |
|POLY 1.5           |     P=0.401N     P=0.493      P=0.498N     P=0.743N    |P=0.172N     P=0.757N     P=0.496N     P=0.501N     |
|POLY 6             |     P=0.371N     P=0.485      P=0.494N     P=0.701N    |P=0.177N     P=0.742N     P=0.486N     P=0.506N     |
|LOGISTIC REGRESSION|     P=0.346N     P=0.487      P=0.496N     P=0.742N    |P=0.169N     P=0.759N     P=0.494N     P=0.502N     |
|COCH-ARM / FISHERS |     P=0.411N     P=0.500      P=0.500N     P=0.753N    |P=0.170N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    6/50 (12%)   2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.3%        0.0%         14.7%        4.5%        |0.0%         2.3%         0.0%         4.7%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     564          ---          527          518         |---          392          ---          444          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.428N     P=0.080N     P=0.388      P=0.235N    |P=0.154      P=0.496      (e)          P=0.237      |
|POLY 3             |     P=0.447N     P=0.069N     P=0.397      P=0.278N    |P=0.156      P=0.512      (e)          P=0.243      |
|POLY 1.5           |     P=0.496N     P=0.065N     P=0.385      P=0.305N    |P=0.153      P=0.506      (e)          P=0.242      |
|POLY 6             |     P=0.377N     P=0.074N     P=0.419      P=0.244N    |P=0.160      P=0.521      (e)          P=0.242      |
|LOGISTIC REGRESSION|     P=0.470      P=0.059N     P=0.350      P=0.404N    |P=0.054      P=0.735      (e)          P=0.166      |
|COCH-ARM / FISHERS |     P=0.553N     P=0.059N     P=0.370      P=0.339N    |P=0.149      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |10/50 (20%)  12/50 (24%)  14/48 (29%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|                                                        |23.7%        27.4%        33.5%        25.7%        |
|TERMINAL (d)       |                                                        |6/28 (21%)   10/33 (30%)  13/34 (38%)  6/28 (21%)   |
|FIRST INCIDENCE    |                                                        |523          535          600          586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.381      P=0.554      P=0.409      P=0.487      |
|POLY 3             |                                                        |P=0.377      P=0.438      P=0.223      P=0.512      |
|POLY 1.5           |                                                        |P=0.377      P=0.415      P=0.214      P=0.508      |
|POLY 6             |                                                        |P=0.371      P=0.477      P=0.241      P=0.515      |
|LOGISTIC REGRESSION|                                                        |P=0.362      P=0.435      P=0.253      P=0.497      |
|COCH-ARM / FISHERS |                                                        |P=0.370      P=0.405      P=0.206      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/50 (8%)    11/50 (22%)  4/48 (8%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |9.4%         24.1%        9.3%         12.0%        |
|TERMINAL (d)       |                                                        |1/28 (4%)    6/33 (18%)   2/34 (6%)    3/28 (11%)   |
|FIRST INCIDENCE    |                                                        |544          337          417          572          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.383N     P=0.080      P=0.590N     P=0.502      |
|POLY 3             |                                                        |P=0.398N     P=0.059      P=0.638N     P=0.487      |
|POLY 1.5           |                                                        |P=0.394N     P=0.051      P=0.638      P=0.494      |
|POLY 6             |                                                        |P=0.410N     P=0.071      P=0.624N     P=0.474      |
|LOGISTIC REGRESSION|                                                        |P=0.408N     P=0.045 *    P=0.587      P=0.500      |
|COCH-ARM / FISHERS |                                                        |P=0.395N     P=0.045 *    P=0.619      P=0.500      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/2 (100%)   1/1 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     715          736 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          507          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.334N     P=0.229      (e)          (e)         |                                                    |
|POLY 3             |     P=0.352N     P=0.234      (e)          (e)         |                                                    |
|POLY 1.5           |     P=0.363N     P=0.235      (e)          (e)         |                                                    |
|POLY 6             |     P=0.331N     P=0.235      (e)          (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.403N     P=0.247      (e)          (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.375N     P=0.247      (e)          (e)         |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/4 (0%)     0/1 (0%)     0/3 (0%)    |2/3 (67%)    0/3 (0%)     0/2 (0%)     0/2 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |70.3%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/2 (0%)     0/1 (0%)     0/3 (0%)    |2/2 (100%)   0/2 (0%)     0/0 (0%)     0/1 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |738 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.132N     P=0.193N     P=1.000N     P=0.362N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.059N     P=0.146N     P=0.485N     P=0.350N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.050N     P=0.152N     P=0.404N     P=0.318N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.066N     P=0.134N     P=0.572N     P=0.393N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.132N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.066N     P=0.200N     P=0.300N     P=0.300N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   3/4 (75%)    0/1 (0%)     3/3 (100%)  |0/3 (0%)     2/3 (67%)    2/2 (100%)   2/2 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       77.1%        0.0%         100.0%      |0.0%         70.3%        100.0%       100.0%       |
|TERMINAL (d)       |     0/0 (0%)     2/2 (100%)   0/1 (0%)     3/3 (100%)  |0/2 (0%)     2/2 (100%)   0/0 (0%)     1/1 (100%)   |
|FIRST INCIDENCE    |     396          592          ---          736 (T)     |---          738 (T)      417          586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.186N     P=0.759N     P=0.510N     (e)         |P=0.041 *    P=0.193      P=0.262      P=0.161      |
|POLY 3             |     P=0.584      P=0.783N     P=1.000N     (e)         |P<0.001 **   P=0.146      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.569      P=0.766N     P=1.000N     (e)         |P<0.001 **   P=0.152      P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.615      P=0.817N     P=1.000N     (e)         |P<0.001 **   P=0.134      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.351      (e)          (e)          (e)         |P=0.028 *    P=0.193      (e)          P=0.174      |
|COCH-ARM / FISHERS |     P=0.550      P=0.800N     P=0.500N     (e)         |P=0.015 *    P=0.200      P=0.100      P=0.100      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Synechia                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/4 (0%)     0/1 (0%)     0/3 (0%)    |0/3 (0%)     2/3 (67%)    0/2 (0%)     0/2 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         66.7%        0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/2 (0%)     0/1 (0%)     0/3 (0%)    |0/2 (0%)     1/2 (50%)    0/0 (0%)     0/1 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          698          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.503N     P=0.257      (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.698N     P=0.172      (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.606N     P=0.165      (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.626      P=0.185      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.610N     P=0.186      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.471N     P=0.200      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   4/4 (100%)   0/1 (0%)     3/3 (100%)  |0/3 (0%)     3/3 (100%)   2/2 (100%)   2/2 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       0.0%         100.0%      |0.0%         100.0%       100.0%       100.0%       |
|TERMINAL (d)       |     0/0 (0%)     2/2 (100%)   0/1 (0%)     3/3 (100%)  |0/2 (0%)     2/2 (100%)   0/0 (0%)     1/1 (100%)   |
|FIRST INCIDENCE    |     396          592          ---          736 (T)     |---          698          417          586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.119N     (e)          P=0.510N     (e)         |P=0.083      P=0.104      P=0.262      P=0.161      |
|POLY 3             |     P=1.000N     (e)          P=1.000N     (e)         |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=1.000N     (e)          P=1.000N     (e)         |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=1.000      (e)          P=1.000N     (e)         |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.032 *    P=0.051      (e)          P=0.174      |
|COCH-ARM / FISHERS |     P=0.567N     (e)          P=0.500N     (e)         |P=0.016 *    P=0.050      P=0.100      P=0.100      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  41/50 (82%)  41/50 (82%)  44/50 (88%) |27/50 (54%)  31/50 (62%)  36/50 (72%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     87.8%        87.0%        89.0%        89.3%       |58.9%        66.8%        79.6%        77.2%        |
|TERMINAL (d)       |     12/12 (100%) 15/16 (94%)  21/21 (100%) 27/31 (87%) |15/28 (54%)  22/33 (67%)  29/34 (85%)  22/28 (79%)  |
|FIRST INCIDENCE    |     396          410          360          213         |461          284          535          459          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.391N     P=0.094N     P<0.001N**  |P=0.055      P=0.554      P=0.290      P=0.114      |
|POLY 3             |     P=0.411      P=0.588N     P=0.565      P=0.541     |P=0.011 *    P=0.280      P=0.021 *    P=0.041 *    |
|POLY 1.5           |     P=0.336      P=0.579N     P=0.600      P=0.433     |P=0.017 *    P=0.266      P=0.028 *    P=0.053      |
|POLY 6             |     P=0.531      P=0.633N     P=0.480      P=0.620N    |P=0.006 **   P=0.313      P=0.017 *    P=0.030 *    |
|LOGISTIC REGRESSION|     P=0.334      P=0.580      P=0.580N     P=0.356     |P=0.030 *    P=0.278      P=0.060      P=0.071      |
|COCH-ARM / FISHERS |     P=0.248      P=0.602N     P=0.602N     P=0.288     |P=0.032 *    P=0.272      P=0.048 *    P=0.074      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   4/50 (8%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     18.5%        18.4%        10.4%        4.6%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     3/12 (25%)   1/16 (6%)    2/21 (10%)   1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     684          507          640          708         |---          620          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003N**   P=0.532N     P=0.109N     P=0.004N**  |P=0.509N     P=0.514      (e)          (e)          |
|POLY 3             |     P=0.018N*    P=0.611N     P=0.242N     P=0.048N*   |P=0.502N     P=0.510      (e)          (e)          |
|POLY 1.5           |     P=0.025N*    P=0.613N     P=0.251N     P=0.061N    |P=0.501N     P=0.504      (e)          (e)          |
|POLY 6             |     P=0.011N*    P=0.596N     P=0.225N     P=0.033N*   |P=0.507N     P=0.520      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.019N*    P=0.588      P=0.210N     P=0.017N*   |P=0.507N     P=0.508      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.037N*    P=0.613N     P=0.262N     P=0.080N    |P=0.500N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    3/49 (6%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     2.7%         7.9%         2.6%         7.0%        |0.0%         4.7%         2.3%         12.3%        |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    1/21 (5%)    1/30 (3%)   |0/28 (0%)    2/33 (6%)    0/34 (0%)    5/28 (18%)   |
|FIRST INCIDENCE    |     736 (T)      410          736 (T)      708         |---          738 (T)      417          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.532      P=0.330      P=0.633N     P=0.596     |P=0.016 *    P=0.275      P=0.500      P=0.032 *    |
|POLY 3             |     P=0.365      P=0.310      P=0.757N     P=0.355     |P=0.018 *    P=0.246      P=0.513      P=0.029 *    |
|POLY 1.5           |     P=0.337      P=0.308      P=0.759N     P=0.328     |P=0.018 *    P=0.240      P=0.507      P=0.030 *    |
|POLY 6             |     P=0.414      P=0.317      P=0.753N     P=0.398     |P=0.019 *    P=0.256      P=0.520      P=0.027 *    |
|LOGISTIC REGRESSION|     P=0.279      P=0.325      P=0.633N     P=0.439     |P=0.018 *    P=0.275      P=0.541      P=0.032 *    |
|COCH-ARM / FISHERS |     P=0.307      P=0.309      P=0.753N     P=0.301     |P=0.018 *    P=0.247      P=0.500      P=0.028 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    3/49 (6%)   |2/50 (4%)    5/50 (10%)   8/50 (16%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     2.7%         13.1%        7.7%         7.0%        |4.9%         11.7%        18.3%        12.1%        |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    3/30 (10%)  |2/28 (7%)    5/33 (15%)   7/34 (21%)   2/28 (7%)    |
|FIRST INCIDENCE    |     643          507          583          736 (T)     |738 (T)      738 (T)      451          605          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.511N     P=0.098      P=0.373      P=0.577     |P=0.116      P=0.284      P=0.081      P=0.216      |
|POLY 3             |     P=0.424      P=0.102      P=0.313      P=0.349     |P=0.124      P=0.231      P=0.055      P=0.218      |
|POLY 1.5           |     P=0.381      P=0.101      P=0.310      P=0.325     |P=0.125      P=0.222      P=0.051      P=0.218      |
|POLY 6             |     P=0.491      P=0.105      P=0.322      P=0.387     |P=0.121      P=0.250      P=0.061      P=0.216      |
|LOGISTIC REGRESSION|     P=0.321      P=0.111      P=0.308      P=0.391     |P=0.116      P=0.284      P=0.054      P=0.210      |
|COCH-ARM / FISHERS |     P=0.336      P=0.102      P=0.309      P=0.301     |P=0.123      P=0.218      P=0.046 *    P=0.218      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/48 (2%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     2/12 (17%)   0/16 (0%)    0/21 (0%)    1/30 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     736 (T)      ---          ---          736 (T)     |---          ---          ---          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.175N     P=0.124N     P=0.200N    |P=0.178      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.309N     P=0.244N     P=0.232N     P=0.462N    |P=0.194      (e)          (e)          P=0.498      |
|POLY 1.5           |     P=0.310N     P=0.241N     P=0.234N     P=0.487N    |P=0.190      (e)          (e)          P=0.499      |
|POLY 6             |     P=0.305N     P=0.245N     P=0.226N     P=0.426N    |P=0.200      (e)          (e)          P=0.495      |
|LOGISTIC REGRESSION|     P=0.126N     (e)          (e)          P=0.200N    |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.309N     P=0.247N     P=0.247N     P=0.515N    |P=0.186      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         10.8%        2.6%         2.3%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    1/21 (5%)    1/31 (3%)   |1/28 (4%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     681          507          736 (T)      736 (T)     |738 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176N     P=0.198      P=0.704N     P=0.616N    |P=0.176N     P=0.467N     P=0.461N     P=0.500N     |
|POLY 3             |     P=0.312N     P=0.172      P=0.758N     P=0.727N    |P=0.192N     P=0.492N     P=0.491N     P=0.502N     |
|POLY 1.5           |     P=0.337N     P=0.175      P=0.759N     P=0.743N    |P=0.188N     P=0.497N     P=0.495N     P=0.501N     |
|POLY 6             |     P=0.273N     P=0.172      P=0.755N     P=0.702N    |P=0.199N     P=0.483N     P=0.485N     P=0.505N     |
|LOGISTIC REGRESSION|     P=0.330N     P=0.176      P=0.751N     P=0.719N    |P=0.176N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.365N     P=0.181      P=0.753N     P=0.753N    |P=0.185N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     50/50 (100%) 49/50 (98%)  50/50 (100%) 49/50 (98%) |44/50 (88%)  46/50 (92%)  44/50 (88%)  48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     100.0%       99.3%        100.0%       100.0%      |95.7%        96.2%        92.8%        97.9%        |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) |
|FIRST INCIDENCE    |     396          410          360          518         |507          284          451          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.359N     (e)          P<0.001N**  |P=0.293      P=0.267N     P=0.126N     P=0.279      |
|POLY 3             |     P=0.856      P=0.981N     (e)          P=1.000N    |P=0.442      P=0.705      P=0.420N     P=0.478      |
|POLY 1.5           |     P=0.757      P=0.774N     (e)          P=1.000N    |P=0.284      P=0.504      P=0.526N     P=0.256      |
|POLY 6             |     P=1.000      P=1.000N     (e)          P=1.000N    |P=0.544N     P=0.678N     P=0.292N     P=0.883      |
|LOGISTIC REGRESSION|     P=0.538N     P=0.506N     (e)          (e)         |P=0.182      P=0.259      P=0.522N     P=0.118      |
|COCH-ARM / FISHERS |     P=0.375N     P=0.500N     (e)          P=0.500N    |P=0.160      P=0.370      P=0.620N     P=0.134      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  48/50 (96%)  49/50 (98%)  50/50 (100%)|48/50 (96%)  48/50 (96%)  50/50 (100%) 50/50 (100%) |
|POLY-3 ADJUSTED (b)|     98.7%        98.4%        99.8%        100.0%      |98.4%        99.6%        100.0%       100.0%       |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) |
|FIRST INCIDENCE    |     396          410          443          213         |391          337          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.353N     P=0.114N     P<0.001N**  |P=0.350      P=0.179N     P=0.246N     P=0.408      |
|POLY 3             |     P=0.207      P=0.832N     P=0.748      P=0.690     |P=0.114      P=0.759      P=0.636      P=0.636      |
|POLY 1.5           |     P=0.204      P=0.685N     P=0.725      P=0.588     |P=0.063      P=0.649      P=0.384      P=0.384      |
|POLY 6             |     P=0.292      P=0.953      P=0.899      P=0.892     |P=0.508      P=0.998      P=0.997      P=0.997      |
|LOGISTIC REGRESSION|     P=0.261      P=0.522N     P=0.744N     P=0.520     |P=0.057      P=0.493      P=0.243      P=0.249      |
|COCH-ARM / FISHERS |     P=0.249      P=0.500N     P=0.753N     P=0.500     |P=0.057      P=0.691N     P=0.247      P=0.247      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         2.6%         2.3%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     647          ---          736 (T)      736 (T)     |---          ---          ---          613          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237N     P=0.241N     P=0.422N     P=0.312N    |P=0.179      (e)          (e)          P=0.495      |
|POLY 3             |     P=0.384N     P=0.246N     P=0.497N     P=0.451N    |P=0.192      (e)          (e)          P=0.500      |
|POLY 1.5           |     P=0.397N     P=0.243N     P=0.498N     P=0.473N    |P=0.189      (e)          (e)          P=0.501      |
|POLY 6             |     P=0.362N     P=0.250N     P=0.493N     P=0.418N    |P=0.197      (e)          (e)          P=0.499      |
|LOGISTIC REGRESSION|     P=0.334N     P=0.244N     P=0.487N     P=0.449N    |P=0.177      (e)          (e)          P=0.495      |
|COCH-ARM / FISHERS |     P=0.411N     P=0.247N     P=0.500N     P=0.500N    |P=0.185      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/50 (34%)  14/50 (28%)  20/50 (40%)  16/50 (32%) |41/50 (82%)  42/50 (84%)  44/50 (88%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     42.0%        37.9%        49.6%        36.2%       |86.2%        92.9%        93.8%        79.0%        |
|TERMINAL (d)       |     10/12 (83%)  12/16 (75%)  16/21 (76%)  14/31 (45%) |27/28 (96%)  33/33 (100%) 34/34 (100%) 25/28 (89%)  |
|FIRST INCIDENCE    |     396          563          360          544         |391          522          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.091N     P=0.197N     P=0.002N**  |P=0.159N     P=0.220N     P=0.302N     P=0.186N     |
|POLY 3             |     P=0.424N     P=0.442N     P=0.314      P=0.368N    |P=0.195N     P=0.213      P=0.154      P=0.237N     |
|POLY 1.5           |     P=0.517N     P=0.396N     P=0.325      P=0.436N    |P=0.138N     P=0.286      P=0.203      P=0.175N     |
|POLY 6             |     P=0.272N     P=0.488N     P=0.310      P=0.261N    |P=0.319N     P=0.191      P=0.119      P=0.345N     |
|LOGISTIC REGRESSION|     P=0.309N     P=0.381N     P=0.358      P=0.339N    |P=0.076N     P=0.501      P=0.332      P=0.107N     |
|COCH-ARM / FISHERS |     P=0.447      P=0.333N     P=0.339      P=0.500N    |P=0.113N     P=0.500      P=0.288      P=0.121N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    7/50 (14%)   5/50 (10%)  |11/50 (22%)  10/50 (20%)  8/50 (16%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     16.0%        5.5%         18.3%        11.5%       |26.8%        23.4%        18.6%        7.4%         |
|TERMINAL (d)       |     6/12 (50%)   2/16 (13%)   7/21 (33%)   5/31 (16%)  |11/28 (39%)  10/33 (30%)  8/34 (24%)   3/28 (11%)   |
|FIRST INCIDENCE    |     736 (T)      736 (T)      736 (T)      736 (T)     |738 (T)      738 (T)      738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.070N     P=0.043N*    P=0.287N     P=0.031N*   |P=0.008N**   P=0.322N     P=0.146N     P=0.016N*    |
|POLY 3             |     P=0.509N     P=0.139N     P=0.516      P=0.393N    |P=0.014N*    P=0.458N     P=0.262N     P=0.018N*    |
|POLY 1.5           |     P=0.527      P=0.137N     P=0.509      P=0.443N    |P=0.014N*    P=0.485N     P=0.282N     P=0.019N*    |
|POLY 6             |     P=0.420N     P=0.138N     P=0.535      P=0.320N    |P=0.015N*    P=0.411N     P=0.235N     P=0.018N*    |
|LOGISTIC REGRESSION|     P=0.070N     P=0.043N*    P=0.287N     P=0.031N*   |P=0.008N**   P=0.322N     P=0.146N     P=0.016N*    |
|COCH-ARM / FISHERS |     P=0.458      P=0.134N     P=0.500      P=0.500N    |P=0.016N*    P=0.500N     P=0.306N     P=0.020N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    9/50 (18%)  |2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     5.3%         5.5%         2.6%         20.4%       |4.8%         2.3%         2.3%         7.3%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    1/21 (5%)    7/31 (23%)  |1/28 (4%)    1/33 (3%)    1/34 (3%)    2/28 (7%)    |
|FIRST INCIDENCE    |     619          649          736 (T)      605         |620          738 (T)      738 (T)      634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.099      P=0.672N     P=0.393N     P=0.243     |P=0.359      P=0.454N     P=0.452N     P=0.491      |
|POLY 3             |     P=0.011 *    P=0.682      P=0.497N     P=0.045 *   |P=0.367      P=0.489N     P=0.488N     P=0.495      |
|POLY 1.5           |     P=0.009 **   P=0.687      P=0.498N     P=0.035 *   |P=0.368      P=0.497N     P=0.493N     P=0.499      |
|POLY 6             |     P=0.014 *    P=0.679      P=0.493N     P=0.065     |P=0.366      P=0.477N     P=0.480N     P=0.488      |
|LOGISTIC REGRESSION|     P=0.025 *    P=0.684      P=0.489N     P=0.057     |P=0.363      P=0.495N     P=0.493N     P=0.498      |
|COCH-ARM / FISHERS |     P=0.009 **   P=0.691N     P=0.500N     P=0.026 *   |P=0.365      P=0.500N     P=0.500N     P=0.500      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    7/50 (14%)   6/50 (12%)   8/50 (16%)  |9/50 (18%)   4/50 (8%)    7/50 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         18.6%        15.1%        17.7%       |21.1%        9.0%         15.8%        7.3%         |
|TERMINAL (d)       |     0/12 (0%)    3/16 (19%)   3/21 (14%)   5/31 (16%)  |6/28 (21%)   2/33 (6%)    5/34 (15%)   2/28 (7%)    |
|FIRST INCIDENCE    |     ---          505          521          213         |475          337          417          704          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.121      P=0.015 *    P=0.039 *    P=0.043 *   |P=0.080N     P=0.089N     P=0.285N     P=0.068N     |
|POLY 3             |     P=0.028 *    P=0.007 **   P=0.018 *    P=0.008 **  |P=0.096N     P=0.097N     P=0.360N     P=0.067N     |
|POLY 1.5           |     P=0.019 *    P=0.007 **   P=0.017 *    P=0.006 **  |P=0.089N     P=0.106N     P=0.374N     P=0.063N     |
|POLY 6             |     P=0.050      P=0.007 **   P=0.020 *    P=0.014 *   |P=0.108N     P=0.086N     P=0.341N     P=0.073N     |
|LOGISTIC REGRESSION|     P=0.009 **   P=0.008 **   P=0.017 *    P=0.003 **  |P=0.085N     P=0.112N     P=0.402N     P=0.062N     |
|COCH-ARM / FISHERS |     P=0.012 *    P=0.006 **   P=0.013 *    P=0.003 **  |P=0.083N     P=0.117N     P=0.393N     P=0.061N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  16/50 (32%)  22/50 (44%)  22/50 (44%) |31/50 (62%)  36/50 (72%)  33/50 (66%)  27/50 (54%)  |
|POLY-3 ADJUSTED (b)|     51.3%        40.0%        52.0%        48.9%       |69.4%        78.5%        73.5%        62.9%        |
|TERMINAL (d)       |     9/12 (75%)   9/16 (56%)   13/21 (62%)  19/31 (61%) |22/28 (79%)  29/33 (88%)  28/34 (82%)  19/28 (68%)  |
|FIRST INCIDENCE    |     396          428          360          544         |507          284          399          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.010N*    P=0.080N     P=0.156N     P=0.003N**  |P=0.180N     P=0.557      P=0.323N     P=0.306N     |
|POLY 3             |     P=0.485      P=0.197N     P=0.564      P=0.494N    |P=0.230N     P=0.217      P=0.421      P=0.329N     |
|POLY 1.5           |     P=0.423      P=0.178N     P=0.567      P=0.545N    |P=0.197N     P=0.197      P=0.420      P=0.298N     |
|POLY 6             |     P=0.468N     P=0.215N     P=0.579      P=0.401N    |P=0.290N     P=0.263      P=0.428      P=0.382N     |
|LOGISTIC REGRESSION|     P=0.457      P=0.152N     P=0.576N     P=0.507N    |P=0.164N     P=0.211      P=0.515      P=0.270N     |
|COCH-ARM / FISHERS |     P=0.374      P=0.151N     P=0.580N     P=0.580N    |P=0.179N     P=0.198      P=0.418      P=0.272N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |7/50 (14%)   7/50 (14%)   5/50 (10%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.7%         0.0%         2.6%         2.3%        |17.0%        16.4%        11.6%        4.9%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |7/28 (25%)   7/33 (21%)   5/34 (15%)   2/28 (7%)    |
|FIRST INCIDENCE    |     736 (T)      ---          645          736 (T)     |738 (T)      738 (T)      738 (T)      738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.532N     P=0.443N     P=0.711N     P=0.537N    |P=0.037N*    P=0.482N     P=0.244N     P=0.075N     |
|POLY 3             |     P=0.555      P=0.507N     P=0.755N     P=0.726N    |P=0.048N*    P=0.583N     P=0.346N     P=0.078N     |
|POLY 1.5           |     P=0.529      P=0.504N     P=0.758N     P=0.742N    |P=0.048N*    P=0.603N     P=0.362N     P=0.078N     |
|POLY 6             |     P=0.593      P=0.509N     P=0.749N     P=0.699N    |P=0.051N     P=0.549N     P=0.324N     P=0.080N     |
|LOGISTIC REGRESSION|     P=0.564      (e)          P=0.757N     P=0.537N    |P=0.037N*    P=0.482N     P=0.244N     P=0.075N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.500N     P=0.753N     P=0.753N    |P=0.049N*    P=0.613N     P=0.380N     P=0.080N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Bile                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         2.3%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    1/34 (3%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          620          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.508N     P=0.271      P=0.539      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.504N     P=0.249      P=0.509      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.501N     P=0.242      P=0.505      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.512N     P=0.261      P=0.515      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.500N     P=0.237      P=0.539      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.247      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.8%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |391          698          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.060N     P=0.462N     P=0.220N     P=0.243N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.061N     P=0.493N     P=0.232N     P=0.244N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.060N     P=0.499N     P=0.235N     P=0.241N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.063N     P=0.479N     P=0.227N     P=0.249N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.062N     P=0.476N     P=0.246N     P=0.248N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.059N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  47/50 (94%)  46/50 (92%)  48/50 (96%) |24/50 (48%)  18/50 (36%)  22/50 (44%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     99.1%        95.4%        94.6%        99.1%       |56.1%        39.5%        46.8%        44.3%        |
|TERMINAL (d)       |     12/12 (100%) 16/16 (100%) 20/21 (95%)  31/31 (100%)|16/28 (57%)  10/33 (30%)  13/34 (38%)  14/28 (50%)  |
|FIRST INCIDENCE    |     396          410          443          518         |585          430          535          586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.313N     P=0.062N     P<0.001N**  |P=0.280N     P=0.073N     P=0.218N     P=0.238N     |
|POLY 3             |     P=0.546N     P=0.286N     P=0.217N     P=0.949     |P=0.240N     P=0.083N     P=0.249N     P=0.183N     |
|POLY 1.5           |     P=0.498N     P=0.291N     P=0.205N     P=0.820N    |P=0.242N     P=0.113N     P=0.320N     P=0.190N     |
|POLY 6             |     P=0.565N     P=0.292N     P=0.227N     P=1.000     |P=0.250N     P=0.054N     P=0.175N     P=0.189N     |
|LOGISTIC REGRESSION|     P=0.229N     P=0.311N     P=0.165N     P=0.407N    |P=0.258N     P=0.131N     P=0.377N     P=0.214N     |
|COCH-ARM / FISHERS |     P=0.332N     P=0.309N     P=0.181N     P=0.500N    |P=0.261N     P=0.156N     P=0.421N     P=0.210N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  22/50 (44%)  28/50 (56%)  39/50 (78%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     40.1%        55.6%        65.2%        81.7%       |0.0%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     4/12 (33%)   11/16 (69%)  14/21 (67%)  24/31 (77%) |0/28 (0%)    0/33 (0%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     576          507          527          561         |---          ---          ---          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176      P=0.289      P=0.182      P=0.218     |P=0.178      (e)          (e)          P=0.500      |
|POLY 3             |     P<0.001 **   P=0.111      P=0.013 *    P<0.001 **  |P=0.193      (e)          (e)          P=0.498      |
|POLY 1.5           |     P<0.001 **   P=0.127      P=0.012 *    P<0.001 **  |P=0.189      (e)          (e)          P=0.499      |
|POLY 6             |     P<0.001 **   P=0.097      P=0.018 *    P<0.001 **  |P=0.199      (e)          (e)          P=0.495      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.102      P=0.013 *    P<0.001 **  |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.151      P=0.013 *    P<0.001 **  |P=0.185      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.8%         0.0%         5.2%         2.3%        |0.0%         2.3%         4.7%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    2/34 (6%)    0/28 (0%)    |
|FIRST INCIDENCE    |     535          ---          521          736 (T)     |---          337          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176N     P=0.139N     P=0.451N     P=0.188N    |P=0.502      P=0.496      P=0.282      (e)          |
|POLY 3             |     P=0.248N     P=0.130N     P=0.498N     P=0.263N    |P=0.496      P=0.512      P=0.247      (e)          |
|POLY 1.5           |     P=0.267N     P=0.125N     P=0.498N     P=0.282N    |P=0.499      P=0.506      P=0.242      (e)          |
|POLY 6             |     P=0.221N     P=0.135N     P=0.495N     P=0.236N    |P=0.488      P=0.521      P=0.254      (e)          |
|LOGISTIC REGRESSION|     P=0.315N     P=0.113N     P=0.511N     P=0.339N    |P=0.483      P=0.905      P=0.282      (e)          |
|COCH-ARM / FISHERS |     P=0.289N     P=0.121N     P=0.500N     P=0.309N    |P=0.500      P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  3/50 (6%)    5/50 (10%)   7/50 (14%)  |7/50 (14%)   2/50 (4%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     24.6%        8.0%         13.0%        15.7%       |16.8%        4.5%         2.3%         7.3%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    4/21 (19%)   6/31 (19%)  |3/28 (11%)   0/33 (0%)    1/34 (3%)    1/28 (4%)    |
|FIRST INCIDENCE    |     396          450          676          213         |645          337          738 (T)      613          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.053N     P=0.050N     P=0.071N     P=0.051N    |P=0.067N     P=0.065N     P=0.022N*    P=0.188N     |
|POLY 3             |     P=0.224N     P=0.044N*    P=0.149N     P=0.224N    |P=0.063N     P=0.064N     P=0.026N*    P=0.158N     |
|POLY 1.5           |     P=0.250N     P=0.040N*    P=0.141N     P=0.254N    |P=0.061N     P=0.071N     P=0.028N*    P=0.157N     |
|POLY 6             |     P=0.189N     P=0.050N     P=0.160N     P=0.187N    |P=0.066N     P=0.056N     P=0.024N*    P=0.163N     |
|LOGISTIC REGRESSION|     P=0.315N     P=0.031N*    P=0.130N     P=0.385N    |P=0.063N     P=0.080N     P=0.026N*    P=0.161N     |
|COCH-ARM / FISHERS |     P=0.283N     P=0.036N*    P=0.131N     P=0.298N    |P=0.062N     P=0.080N     P=0.030N*    P=0.159N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         2.8%         2.6%         2.3%        |0.0%         0.0%         2.3%         2.5%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     617          726          593          621         |---          ---          733          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.235N     P=0.488N     P=0.466N     P=0.387N    |P=0.164      (e)          P=0.545      P=0.500      |
|POLY 3             |     P=0.308N     P=0.516N     P=0.493N     P=0.448N    |P=0.171      (e)          P=0.509      P=0.498      |
|POLY 1.5           |     P=0.325N     P=0.509N     P=0.496N     P=0.472N    |P=0.172      (e)          P=0.505      P=0.499      |
|POLY 6             |     P=0.283N     P=0.522N     P=0.486N     P=0.413N    |P=0.170      (e)          P=0.515      P=0.495      |
|LOGISTIC REGRESSION|     P=0.351N     P=0.512N     P=0.503N     P=0.526N    |P=0.156      (e)          P=0.524      P=0.500      |
|COCH-ARM / FISHERS |     P=0.343N     P=0.500N     P=0.500N     P=0.500N    |P=0.170      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         10.7%        2.6%         4.6%        |4.7%         0.0%         4.6%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     729          410          640          708         |391          ---          399          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.181N     P=0.390      P=0.400N     P=0.381N    |P=0.241N     P=0.244N     P=0.668N     P=0.230N     |
|POLY 3             |     P=0.325N     P=0.335      P=0.490N     P=0.637N    |P=0.265N     P=0.235N     P=0.683N     P=0.246N     |
|POLY 1.5           |     P=0.351N     P=0.336      P=0.495N     P=0.664N    |P=0.256N     P=0.239N     P=0.688N     P=0.242N     |
|POLY 6             |     P=0.283N     P=0.340      P=0.480N     P=0.595N    |P=0.282N     P=0.229N     P=0.675N     P=0.253N     |
|LOGISTIC REGRESSION|     P=0.367N     P=0.333      P=0.485N     P=0.515N    |P=0.283N     P=0.125N     P=0.687      P=0.250N     |
|COCH-ARM / FISHERS |     P=0.380N     P=0.339      P=0.500N     P=0.691N    |P=0.249N     P=0.247N     P=0.691N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    5/50 (10%)   4/50 (8%)   |12/50 (24%)  12/50 (24%)  17/50 (34%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     7.7%         0.0%         13.0%        9.2%        |27.9%        27.4%        39.6%        36.1%        |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    4/21 (19%)   4/31 (13%)  |7/28 (25%)   10/33 (30%)  17/34 (50%)  13/28 (46%)  |
|FIRST INCIDENCE    |     396          ---          676          736 (T)     |523          522          738 (T)      605          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.510      P=0.126N     P=0.533      P=0.478N    |P=0.168      P=0.447N     P=0.362      P=0.315      |
|POLY 3             |     P=0.238      P=0.131N     P=0.348      P=0.563     |P=0.137      P=0.575N     P=0.176      P=0.279      |
|POLY 1.5           |     P=0.206      P=0.126N     P=0.351      P=0.533     |P=0.158      P=0.590N     P=0.181      P=0.303      |
|POLY 6             |     P=0.292      P=0.135N     P=0.351      P=0.610     |P=0.106      P=0.547N     P=0.170      P=0.241      |
|LOGISTIC REGRESSION|     P=0.221      P=0.106N     P=0.358      P=0.476     |P=0.160      P=0.577N     P=0.235      P=0.311      |
|COCH-ARM / FISHERS |     P=0.176      P=0.121N     P=0.357      P=0.500     |P=0.180      P=0.592N     P=0.189      P=0.326      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    2/50 (4%)   |5/50 (10%)   2/50 (4%)    5/50 (10%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.7%         13.5%        7.8%         4.6%        |12.1%        4.7%         11.6%        7.2%         |
|TERMINAL (d)       |     1/12 (8%)    3/16 (19%)   2/21 (10%)   2/31 (7%)   |4/28 (14%)   1/33 (3%)    4/34 (12%)   1/28 (4%)    |
|FIRST INCIDENCE    |     736 (T)      435          593          736 (T)     |645          731          690          588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.249N     P=0.153      P=0.459      P=0.672N    |P=0.404N     P=0.164N     P=0.525N     P=0.360N     |
|POLY 3             |     P=0.519N     P=0.096      P=0.316      P=0.553     |P=0.406N     P=0.202N     P=0.605N     P=0.352N     |
|POLY 1.5           |     P=0.557      P=0.099      P=0.311      P=0.528     |P=0.402N     P=0.211N     P=0.617N     P=0.353N     |
|POLY 6             |     P=0.449N     P=0.095      P=0.327      P=0.589     |P=0.418N     P=0.187N     P=0.587N     P=0.354N     |
|LOGISTIC REGRESSION|     P=0.536N     P=0.096      P=0.318      P=0.672N    |P=0.408N     P=0.182N     P=0.582N     P=0.357N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.102      P=0.309      P=0.500     |P=0.405N     P=0.218N     P=0.630N     P=0.357N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  37/50 (74%)  39/50 (78%)  40/50 (80%) |41/50 (82%)  42/50 (84%)  45/50 (90%)  46/50 (92%)  |
|POLY-3 ADJUSTED (b)|     84.4%        81.9%        84.1%        86.4%       |89.0%        90.5%        93.8%        96.0%        |
|TERMINAL (d)       |     10/12 (83%)  11/16 (69%)  18/21 (86%)  28/31 (90%) |28/28 (100%) 32/33 (97%)  33/34 (97%)  28/28 (100%) |
|FIRST INCIDENCE    |     396          435          443          544         |461          430          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.344N     P=0.143N     P<0.001N**  |P=0.150      P=0.221N     P=0.365N     P=0.218      |
|POLY 3             |     P=0.391      P=0.481N     P=0.608N     P=0.508     |P=0.071      P=0.548      P=0.301      P=0.138      |
|POLY 1.5           |     P=0.378      P=0.459N     P=0.604N     P=0.492     |P=0.065      P=0.489      P=0.248      P=0.128      |
|POLY 6             |     P=0.392      P=0.474N     P=0.616N     P=0.524     |P=0.072      P=0.668N     P=0.386      P=0.151      |
|LOGISTIC REGRESSION|     P=0.449N     P=0.452N     P=0.577N     P=0.427N    |P=0.055      P=0.510      P=0.228      P=0.106      |
|COCH-ARM / FISHERS |     P=0.381      P=0.408N     P=0.595N     P=0.500     |P=0.055      P=0.500      P=0.194      P=0.117      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.2%         2.3%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          666          736 (T)     |698          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.285      (e)          P=0.300      P=0.689     |P=0.191N     P=0.468N     P=0.489N     P=0.525N     |
|POLY 3             |     P=0.200      (e)          P=0.242      P=0.530     |P=0.191N     P=0.497N     P=0.492N     P=0.503N     |
|POLY 1.5           |     P=0.175      (e)          P=0.240      P=0.516     |P=0.187N     P=0.502N     P=0.496N     P=0.501N     |
|POLY 6             |     P=0.241      (e)          P=0.248      P=0.551     |P=0.198N     P=0.490N     P=0.486N     P=0.506N     |
|LOGISTIC REGRESSION|     P=0.202      (e)          P=0.246      P=0.689     |P=0.184N     P=0.502N     P=0.496N     P=0.501N     |
|COCH-ARM / FISHERS |     P=0.149      (e)          P=0.247      P=0.500     |P=0.185N     P=0.505N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         7.9%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    3/21 (14%)   0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      736 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491N     P=0.557      P=0.232      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.519      P=0.493      P=0.121      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.468      P=0.496      P=0.120      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.592      P=0.491      P=0.124      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.557      P=0.232      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.411      P=0.500      P=0.121      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  19/50 (38%)  23/50 (46%)  36/50 (72%) |30/50 (60%)  22/50 (44%)  21/50 (42%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     58.0%        46.6%        55.8%        77.6%       |66.1%        48.4%        43.9%        52.9%        |
|TERMINAL (d)       |     5/12 (42%)   7/16 (44%)   11/21 (52%)  25/31 (81%) |18/28 (64%)  14/33 (42%)  11/34 (32%)  13/28 (46%)  |
|FIRST INCIDENCE    |     396          507          593          605         |507          337          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.211N     P=0.156N     P=0.147N     P=0.127N    |P=0.172N     P=0.038N*    P=0.032N*    P=0.223N     |
|POLY 3             |     P=0.011 *    P=0.194N     P=0.507N     P=0.029 *   |P=0.096N     P=0.064N     P=0.022N*    P=0.137N     |
|POLY 1.5           |     P=0.009 **   P=0.177N     P=0.470N     P=0.021 *   |P=0.102N     P=0.071N     P=0.031N*    P=0.140N     |
|POLY 6             |     P=0.018 *    P=0.215N     P=0.545N     P=0.052     |P=0.097N     P=0.055N     P=0.017N*    P=0.146N     |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.169N     P=0.394N     P=0.057     |P=0.127N     P=0.073N     P=0.059N     P=0.158N     |
|COCH-ARM / FISHERS |     P=0.011 *    P=0.157N     P=0.421N     P=0.020 *   |P=0.127N     P=0.080N     P=0.055N     P=0.158N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         4.7%        |0.0%         0.0%         7.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    1/30 (3%)   |0/28 (0%)    0/33 (0%)    3/34 (9%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          666          684         |---          ---          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.118      (e)          P=0.500      P=0.385     |P=0.297      (e)          P=0.157      (e)          |
|POLY 3             |     P=0.074      (e)          P=0.505      P=0.268     |P=0.287      (e)          P=0.126      (e)          |
|POLY 1.5           |     P=0.066      (e)          P=0.503      P=0.251     |P=0.294      (e)          P=0.123      (e)          |
|POLY 6             |     P=0.088      (e)          P=0.511      P=0.295     |P=0.274      (e)          P=0.132      (e)          |
|LOGISTIC REGRESSION|     P=0.071      (e)          P=0.501      P=0.280     |(e)          (e)          P=0.157      (e)          |
|COCH-ARM / FISHERS |     P=0.058      (e)          P=0.500      P=0.242     |P=0.301      (e)          P=0.121      (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/47 (0%)    1/50 (2%)    1/49 (2%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         2.3%        |4.9%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |2/28 (7%)    1/33 (3%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722          736 (T)     |738 (T)      731          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.292      (e)          P=0.560      P=0.689     |P=0.051N     P=0.634N     P=0.196N     P=0.238N     |
|POLY 3             |     P=0.213      (e)          P=0.508      P=0.531     |P=0.057N     P=0.680N     P=0.227N     P=0.239N     |
|POLY 1.5           |     P=0.194      (e)          P=0.506      P=0.517     |P=0.056N     P=0.689N     P=0.232N     P=0.238N     |
|POLY 6             |     P=0.244      (e)          P=0.513      P=0.553     |P=0.057N     P=0.664N     P=0.220N     P=0.242N     |
|LOGISTIC REGRESSION|     P=0.253      (e)          P=0.527      P=0.689     |P=0.052N     P=0.635N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.173      (e)          P=0.505      P=0.500     |P=0.057N     P=0.691N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     36/49 (73%)  34/47 (72%)  24/50 (48%)  28/49 (57%) |43/50 (86%)  44/50 (88%)  45/50 (90%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     79.7%        79.9%        56.7%        62.6%       |88.2%        93.4%        94.3%        86.4%        |
|TERMINAL (d)       |     8/12 (67%)   11/16 (69%)  11/21 (52%)  20/31 (65%) |24/28 (86%)  32/33 (97%)  32/34 (94%)  24/28 (86%)  |
|FIRST INCIDENCE    |     396          524          443          561         |461          392          451          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.346N     P=0.005N**   P<0.001N**  |P=0.476N     P=0.267N     P=0.288N     P=0.513N     |
|POLY 3             |     P=0.006N**   P=0.602      P=0.011N*    P=0.049N*   |P=0.448N     P=0.292      P=0.232      P=0.516N     |
|POLY 1.5           |     P=0.007N**   P=0.592N     P=0.008N**   P=0.057N    |P=0.429N     P=0.342      P=0.276      P=0.495N     |
|POLY 6             |     P=0.006N**   P=0.610      P=0.020N*    P=0.043N*   |P=0.512N     P=0.272      P=0.213      P=0.574N     |
|LOGISTIC REGRESSION|     P=0.002N**   P=0.537N     P=0.007N**   P=0.029N*   |P=0.437N     P=0.481      P=0.420      P=0.500N     |
|COCH-ARM / FISHERS |     P=0.011N*    P=0.542N     P=0.008N**   P=0.068N    |P=0.463N     P=0.500      P=0.380      P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/15 (80%)  8/12 (67%)   8/15 (53%)   8/11 (73%)  |3/8 (38%)    0/1 (0%)     3/5 (60%)    1/5 (20%)    |
|POLY-3 ADJUSTED (b)|     83.4%        73.2%        60.3%        77.5%       |42.2%        0.0%         71.7%        25.2%        |
|TERMINAL (d)       |     3/3 (100%)   0/1 (0%)     3/6 (50%)    5/5 (100%)  |2/5 (40%)    0/1 (0%)     2/2 (100%)   1/2 (50%)    |
|FIRST INCIDENCE    |     593          534          563          610         |391          ---          684          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.016N*    P=0.393N     P=0.091N     P=0.025N*   |P=0.491      P=0.322N     P=0.358      P=0.575N     |
|POLY 3             |     P=0.285N     P=0.443N     P=0.158N     P=0.560N    |P=0.571N     P=0.611N     P=0.367      P=0.532N     |
|POLY 1.5           |     P=0.275N     P=0.408N     P=0.140N     P=0.542N    |P=0.525N     P=0.620N     P=0.396      P=0.503N     |
|POLY 6             |     P=0.293N     P=0.495N     P=0.188N     P=0.574N    |P=0.515      P=0.599N     P=0.308      P=0.591N     |
|LOGISTIC REGRESSION|     P=0.243N     P=0.302N     P=0.119N     P=0.497N    |P=0.479N     P=0.714N     P=0.419      P=0.495N     |
|COCH-ARM / FISHERS |     P=0.258N     P=0.364N     P=0.123N     P=0.509N    |P=0.488N     P=0.667N     P=0.413      P=0.490N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Fungus                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     21/50 (42%)  15/50 (30%)  10/50 (20%)  11/50 (22%) |6/50 (12%)   2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     49.1%        36.9%        24.9%        24.2%       |13.9%        4.6%         2.3%         0.0%         |
|TERMINAL (d)       |     6/12 (50%)   3/16 (19%)   5/21 (24%)   6/31 (19%)  |1/28 (4%)    0/33 (0%)    1/34 (3%)    0/28 (0%)    |
|FIRST INCIDENCE    |     396          450          557          544         |461          337          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.157N     P=0.004N**   P<0.001N**  |P=0.003N**   P=0.123N     P=0.051N     P=0.021N*    |
|POLY 3             |     P=0.003N**   P=0.174N     P=0.016N*    P=0.011N*   |P=0.003N**   P=0.127N     P=0.056N     P=0.018N*    |
|POLY 1.5           |     P=0.005N**   P=0.164N     P=0.015N*    P=0.016N*   |P=0.003N**   P=0.132N     P=0.056N     P=0.017N*    |
|POLY 6             |     P=0.002N**   P=0.175N     P=0.017N*    P=0.006N**  |P=0.003N**   P=0.119N     P=0.054N     P=0.020N*    |
|LOGISTIC REGRESSION|     P=0.009N**   P=0.146N     P=0.015N*    P=0.033N*   |P=0.003N**   P=0.109N     P=0.064N     P=0.017N*    |
|COCH-ARM / FISHERS |     P=0.009N**   P=0.149N     P=0.015N*    P=0.026N*   |P=0.003N**   P=0.134N     P=0.056N     P=0.013N*    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  19/50 (38%)  22/50 (44%)  18/50 (36%) |13/50 (26%)  13/50 (26%)  7/50 (14%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     57.5%        46.7%        52.8%        39.5%       |29.9%        28.9%        16.1%        14.4%        |
|TERMINAL (d)       |     7/12 (58%)   7/16 (44%)   13/21 (62%)  11/31 (36%) |7/28 (25%)   8/33 (24%)   6/34 (18%)   4/28 (14%)   |
|FIRST INCIDENCE    |     396          450          521          544         |461          337          544          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.142N     P=0.075N     P<0.001N**  |P=0.020N*    P=0.450N     P=0.062N     P=0.072N     |
|POLY 3             |     P=0.068N     P=0.208N     P=0.408N     P=0.061N    |P=0.021N*    P=0.555N     P=0.098N     P=0.069N     |
|POLY 1.5           |     P=0.097N     P=0.185N     P=0.379N     P=0.083N    |P=0.020N*    P=0.577N     P=0.101N     P=0.065N     |
|POLY 6             |     P=0.038N*    P=0.230N     P=0.443N     P=0.037N*   |P=0.025N*    P=0.517N     P=0.093N     P=0.077N     |
|LOGISTIC REGRESSION|     P=0.087N     P=0.166N     P=0.328N     P=0.097N    |P=0.019N*    P=0.588      P=0.103N     P=0.063N     |
|COCH-ARM / FISHERS |     P=0.138N     P=0.157N     P=0.344N     P=0.113N    |P=0.019N*    P=0.590N     P=0.105N     P=0.062N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   6/50 (12%)   5/50 (10%)  |9/50 (18%)   6/50 (12%)   10/50 (20%)  6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     15.7%        16.3%        14.9%        11.5%       |21.2%        13.9%        22.6%        14.2%        |
|TERMINAL (d)       |     1/12 (8%)    2/16 (13%)   2/21 (10%)   4/31 (13%)  |5/28 (18%)   4/33 (12%)   6/34 (18%)   3/28 (11%)   |
|FIRST INCIDENCE    |     617          631          482          712         |523          701          600          459          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.093N     P=0.544N     P=0.469N     P=0.118N    |P=0.368N     P=0.200N     P=0.554N     P=0.301N     |
|POLY 3             |     P=0.311N     P=0.595      P=0.586N     P=0.406N    |P=0.361N     P=0.276N     P=0.538      P=0.286N     |
|POLY 1.5           |     P=0.361N     P=0.606      P=0.600N     P=0.449N    |P=0.357N     P=0.287N     P=0.520      P=0.285N     |
|POLY 6             |     P=0.243N     P=0.588      P=0.563N     P=0.346N    |P=0.377N     P=0.255N     P=0.567      P=0.295N     |
|LOGISTIC REGRESSION|     P=0.328N     P=0.595      P=0.620N     P=0.308N    |P=0.363N     P=0.269N     P=0.516      P=0.287N     |
|COCH-ARM / FISHERS |     P=0.421N     P=0.620N     P=0.620N     P=0.500N    |P=0.363N     P=0.288N     P=0.500      P=0.288N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/50 (48%)  16/50 (32%)  17/50 (34%)  13/50 (26%) |10/50 (20%)  3/50 (6%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     56.1%        40.1%        41.9%        28.9%       |23.2%        7.0%         4.7%         9.7%         |
|TERMINAL (d)       |     7/12 (58%)   5/16 (31%)   10/21 (48%)  8/31 (26%)  |5/28 (18%)   2/33 (6%)    2/34 (6%)    2/28 (7%)    |
|FIRST INCIDENCE    |     396          507          527          610         |461          700          738 (T)      586          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.080N     P=0.019N*    P<0.001N**  |P=0.026N*    P=0.026N*    P=0.010N*    P=0.086N     |
|POLY 3             |     P=0.006N**   P=0.097N     P=0.128N     P=0.007N**  |P=0.025N*    P=0.034N*    P=0.013N*    P=0.082N     |
|POLY 1.5           |     P=0.011N*    P=0.088N     P=0.119N     P=0.010N*   |P=0.024N*    P=0.036N*    P=0.013N*    P=0.077N     |
|POLY 6             |     P=0.003N**   P=0.102N     P=0.139N     P=0.003N**  |P=0.027N*    P=0.030N*    P=0.012N*    P=0.089N     |
|LOGISTIC REGRESSION|     P=0.009N**   P=0.084N     P=0.100N     P=0.013N*   |P=0.026N*    P=0.037N*    P=0.016N*    P=0.075N     |
|COCH-ARM / FISHERS |     P=0.020N*    P=0.076N     P=0.111N     P=0.019N*   |P=0.026N*    P=0.036N*    P=0.014N*    P=0.074N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  9/50 (18%)   8/50 (16%)   7/50 (14%)  |3/50 (6%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     28.8%        23.0%        20.0%        15.6%       |7.2%         7.0%         0.0%         2.4%         |
|TERMINAL (d)       |     1/12 (8%)    2/16 (13%)   4/21 (19%)   3/31 (10%)  |1/28 (4%)    2/33 (6%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     396          450          527          544         |543          700          ---          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.017N*    P=0.338N     P=0.144N     P=0.032N*   |P=0.080N     P=0.598N     P=0.101N     P=0.298N     |
|POLY 3             |     P=0.071N     P=0.365N     P=0.249N     P=0.107N    |P=0.083N     P=0.650N     P=0.113N     P=0.309N     |
|POLY 1.5           |     P=0.088N     P=0.343N     P=0.239N     P=0.128N    |P=0.083N     P=0.659N     P=0.116N     P=0.306N     |
|POLY 6             |     P=0.050N     P=0.387N     P=0.259N     P=0.081N    |P=0.084N     P=0.632N     P=0.109N     P=0.314N     |
|LOGISTIC REGRESSION|     P=0.143N     P=0.286N     P=0.234N     P=0.224N    |P=0.085N     P=0.657N     P=0.123N     P=0.306N     |
|COCH-ARM / FISHERS |     P=0.108N     P=0.312N     P=0.227N     P=0.154N    |P=0.084N     P=0.661N     P=0.121N     P=0.309N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/50 (8%)    6/50 (12%)   4/50 (8%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|                                                        |9.6%         13.8%        9.2%         18.8%        |
|TERMINAL (d)       |                                                        |3/28 (11%)   5/33 (15%)   2/34 (6%)    5/28 (18%)   |
|FIRST INCIDENCE    |                                                        |573          535          647          444          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.188      P=0.456      P=0.551N     P=0.194      |
|POLY 3             |                                                        |P=0.190      P=0.395      P=0.622N     P=0.184      |
|POLY 1.5           |                                                        |P=0.188      P=0.379      P=0.632N     P=0.183      |
|POLY 6             |                                                        |P=0.190      P=0.422      P=0.606N     P=0.182      |
|LOGISTIC REGRESSION|                                                        |P=0.181      P=0.380      P=0.627N     P=0.178      |
|COCH-ARM / FISHERS |                                                        |P=0.182      P=0.370      P=0.643N     P=0.178      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  27/50 (54%)  16/50 (32%)  27/48 (56%) |10/50 (20%)  14/49 (29%)  14/50 (28%)  9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     30.6%        62.4%        41.5%        61.2%       |23.7%        32.8%        31.9%        21.6%        |
|TERMINAL (d)       |     4/12 (33%)   7/16 (44%)   13/21 (62%)  18/30 (60%) |6/28 (21%)   12/33 (36%)  12/34 (35%)  6/28 (21%)   |
|FIRST INCIDENCE    |     600          428          666          605         |585          535          544          605          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.322N     P=0.014 *    P=0.479N     P=0.390     |P=0.438N     P=0.391      P=0.412      P=0.512N     |
|POLY 3             |     P=0.021 *    P=0.002 **   P=0.217      P=0.003 **  |P=0.442N     P=0.245      P=0.270      P=0.509N     |
|POLY 1.5           |     P=0.013 *    P=0.002 **   P=0.235      P<0.001 **  |P=0.433N     P=0.228      P=0.257      P=0.503N     |
|POLY 6             |     P=0.046 *    P=0.004 **   P=0.192      P=0.010 *   |P=0.465N     P=0.277      P=0.290      P=0.524N     |
|LOGISTIC REGRESSION|     P=0.039 *    P=0.002 **   P=0.296      P=0.006 **  |P=0.445N     P=0.260      P=0.283      P=0.511N     |
|COCH-ARM / FISHERS |     P=0.011 *    P=0.002 **   P=0.252      P<0.001 **  |P=0.434N     P=0.224      P=0.241      P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/47 (19%)   3/45 (7%)    0/47 (0%)    0/46 (0%)   |1/46 (2%)    0/44 (0%)    0/41 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     24.8%        9.1%         0.0%         0.0%        |2.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/12 (25%)   1/14 (7%)    0/20 (0%)    0/28 (0%)   |0/25 (0%)    0/29 (0%)    0/26 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     681          544          ---          ---         |704          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.059N     P<0.001N**   P<0.001N**  |P=0.184N     P=0.471N     P=0.477N     P=0.513N     |
|POLY 3             |     P<0.001N**   P=0.076N     P<0.001N**   P<0.001N**  |P=0.199N     P=0.498N     P=0.518N     P=0.499N     |
|POLY 1.5           |     P<0.001N**   P=0.072N     P<0.001N**   P<0.001N**  |P=0.194N     P=0.504N     P=0.521N     P=0.498N     |
|POLY 6             |     P<0.001N**   P=0.082N     P<0.001N**   P<0.001N**  |P=0.206N     P=0.489N     P=0.514N     P=0.502N     |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.084N     P=0.002N**   P<0.001N**  |P=0.189N     P=0.503N     P=0.519N     P=0.498N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.070N     P<0.001N**   P<0.001N**  |P=0.189N     P=0.511N     P=0.529N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   8/50 (16%)   3/49 (6%)    6/50 (12%)  |35/50 (70%)  28/50 (56%)  34/50 (68%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     18.3%        21.7%        7.8%         13.5%       |76.0%        61.5%        75.4%        68.9%        |
|TERMINAL (d)       |     3/12 (25%)   6/16 (38%)   1/21 (5%)    3/31 (10%)  |23/28 (82%)  19/33 (58%)  27/34 (79%)  19/28 (68%)  |
|FIRST INCIDENCE    |     579          563          583          614         |475          392          563          444          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.027N*    P=0.587N     P=0.080N     P=0.117N    |P=0.456N     P=0.040N*    P=0.151N     P=0.385N     |
|POLY 3             |     P=0.171N     P=0.467      P=0.149N     P=0.384N    |P=0.425N     P=0.093N     P=0.576N     P=0.291N     |
|POLY 1.5           |     P=0.207N     P=0.481      P=0.157N     P=0.437N    |P=0.424N     P=0.104N     P=0.548N     P=0.304N     |
|POLY 6             |     P=0.122N     P=0.454      P=0.135N     P=0.308N    |P=0.443N     P=0.073N     P=0.594N     P=0.286N     |
|LOGISTIC REGRESSION|     P=0.155N     P=0.465      P=0.154N     P=0.403N    |P=0.440N     P=0.092N     P=0.410N     P=0.335N     |
|COCH-ARM / FISHERS |     P=0.252N     P=0.500      P=0.167N     P=0.500N    |P=0.447N     P=0.107N     P=0.500N     P=0.335N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  13/50 (26%)  15/49 (31%)  21/50 (42%) |24/50 (48%)  21/50 (42%)  26/50 (52%)  27/50 (54%)  |
|POLY-3 ADJUSTED (b)|     53.8%        33.2%        36.0%        45.9%       |53.9%        47.5%        56.8%        58.7%        |
|TERMINAL (d)       |     6/12 (50%)   3/16 (19%)   8/21 (38%)   13/31 (42%) |16/28 (57%)  15/33 (46%)  19/34 (56%)  16/28 (57%)  |
|FIRST INCIDENCE    |     593          534          360          544         |475          620          451          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.021N*    P=0.054N     P=0.029N*    P=0.010N*   |P=0.224      P=0.172N     P=0.442N     P=0.356      |
|POLY 3             |     P=0.321N     P=0.043N*    P=0.071N     P=0.299N    |P=0.251      P=0.348N     P=0.472      P=0.397      |
|POLY 1.5           |     P=0.402N     P=0.043N*    P=0.086N     P=0.386N    |P=0.240      P=0.362N     P=0.447      P=0.381      |
|POLY 6             |     P=0.227N     P=0.045N*    P=0.061N     P=0.203N    |P=0.251      P=0.305N     P=0.515      P=0.406      |
|LOGISTIC REGRESSION|     P=0.384N     P=0.054N     P=0.110N     P=0.278N    |P=0.205      P=0.309N     P=0.455      P=0.344      |
|COCH-ARM / FISHERS |     P=0.509N     P=0.046N*    P=0.121N     P=0.500N    |P=0.205      P=0.344N     P=0.421      P=0.345      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/49 (6%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         7.7%         2.3%        |2.4%         4.7%         0.0%         2.5%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    2/33 (6%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |     ---          708          572          736 (T)     |698          738 (T)      ---          738 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.339      P=0.520      P=0.127      P=0.689     |P=0.416N     P=0.557      P=0.489N     P=0.747      |
|POLY 3             |     P=0.284      P=0.494      P=0.124      P=0.530     |P=0.410N     P=0.513      P=0.492N     P=0.758      |
|POLY 1.5           |     P=0.247      P=0.496      P=0.120      P=0.516     |P=0.410N     P=0.504      P=0.496N     P=0.760      |
|POLY 6             |     P=0.344      P=0.493      P=0.133      P=0.551     |P=0.412N     P=0.527      P=0.486N     P=0.754      |
|LOGISTIC REGRESSION|     P=0.204      P=0.493      P=0.111      P=0.689     |P=0.418N     P=0.530      P=0.496N     P=0.758      |
|COCH-ARM / FISHERS |     P=0.208      P=0.500      P=0.117      P=0.500     |P=0.411N     P=0.500      P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   7/50 (14%)   4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     18.2%        18.5%        17.9%        9.1%        |                                                    |
|TERMINAL (d)       |     5/12 (42%)   3/16 (19%)   4/21 (19%)   3/31 (10%)  |                                                    |
|FIRST INCIDENCE    |     396          435          572          660         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.020N*    P=0.497N     P=0.337N     P=0.022N*   |                                                    |
|POLY 3             |     P=0.141N     P=0.606      P=0.602N     P=0.188N    |                                                    |
|POLY 1.5           |     P=0.178N     P=0.606      P=0.609N     P=0.222N    |                                                    |
|POLY 6             |     P=0.093N     P=0.617      P=0.580N     P=0.142N    |                                                    |
|LOGISTIC REGRESSION|     P=0.175N     P=0.603      P=0.599N     P=0.203N    |                                                    |
|COCH-ARM / FISHERS |     P=0.222N     P=0.613N     P=0.613N     P=0.262N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  40/50 (80%)  47/50 (94%)  47/50 (94%) |                                                    |
|POLY-3 ADJUSTED (b)|     92.0%        86.0%        96.8%        97.0%       |                                                    |
|TERMINAL (d)       |     12/12 (100%) 13/16 (81%)  20/21 (95%)  30/31 (97%) |                                                    |
|FIRST INCIDENCE    |     396          410          443          518         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004N**   P=0.306N     P=0.279N     P<0.001N**  |                                                    |
|POLY 3             |     P=0.045 *    P=0.245N     P=0.238      P=0.224     |                                                    |
|POLY 1.5           |     P=0.021 *    P=0.313N     P=0.140      P=0.122     |                                                    |
|POLY 6             |     P=0.144      P=0.155N     P=0.543      P=0.541     |                                                    |
|LOGISTIC REGRESSION|     P=0.048 *    P=0.456N     P=0.098      P=0.290     |                                                    |
|COCH-ARM / FISHERS |     P=0.020 *    P=0.398N     P=0.100      P=0.100     |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         5.2%         0.0%        |                                                    |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    1/21 (5%)    0/31 (0%)   |                                                    |
|FIRST INCIDENCE    |     561          ---          666          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.143N     P=0.238N     P=0.608N     P=0.152N    |                                                    |
|POLY 3             |     P=0.209N     P=0.247N     P=0.691N     P=0.208N    |                                                    |
|POLY 1.5           |     P=0.227N     P=0.243N     P=0.692N     P=0.221N    |                                                    |
|POLY 6             |     P=0.183N     P=0.251N     P=0.685N     P=0.189N    |                                                    |
|LOGISTIC REGRESSION|     P=0.237N     P=0.236N     P=0.692N     P=0.255N    |                                                    |
|COCH-ARM / FISHERS |     P=0.249N     P=0.247N     P=0.691N     P=0.247N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     38/50 (76%)  34/50 (68%)  32/50 (64%)  26/49 (53%) |                                                    |
|POLY-3 ADJUSTED (b)|     79.2%        73.1%        67.9%        54.9%       |                                                    |
|TERMINAL (d)       |     8/12 (67%)   10/16 (63%)  10/21 (48%)  15/30 (50%) |                                                    |
|FIRST INCIDENCE    |     396          410          360          213         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.260N     P=0.072N     P<0.001N**  |                                                    |
|POLY 3             |     P=0.004N**   P=0.316N     P=0.144N     P=0.008N**  |                                                    |
|POLY 1.5           |     P=0.006N**   P=0.288N     P=0.141N     P=0.010N*   |                                                    |
|POLY 6             |     P=0.002N**   P=0.351N     P=0.147N     P=0.005N**  |                                                    |
|LOGISTIC REGRESSION|     P=0.033N*    P=0.221N     P=0.146N     P=0.055N    |                                                    |
|COCH-ARM / FISHERS |     P=0.010N*    P=0.252N     P=0.138N     P=0.014N*   |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          736 (T)      ---          707         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.310      P=0.557      (e)          P=0.428     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.171      P=0.493      (e)          P=0.273     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.160      P=0.496      (e)          P=0.256     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.190      P=0.491      (e)          P=0.301     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.235      P=0.557      (e)          P=0.318     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.149      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.8%         7.9%         6.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    3/21 (14%)   3/31 (10%)  |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          726          736 (T)      736 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.201      P=0.525      P=0.232      P=0.328     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.065      P=0.493      P=0.121      P=0.148     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.054      P=0.496      P=0.120      P=0.134     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.088      P=0.492      P=0.124      P=0.172     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.155      P=0.506      P=0.232      P=0.328     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    P=0.500      P=0.121      P=0.121     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         0.0%         0.0%         0.0%        |2.4%         0.0%         4.6%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |1/28 (4%)    0/33 (0%)    1/34 (3%)    0/28 (0%)    |
|FIRST INCIDENCE    |     663          ---          ---          ---         |738 (T)      ---          600          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.168N     P=0.521N     P=0.507N     P=0.448N    |P=0.496N     P=0.467N     P=0.553      P=0.500N     |
|POLY 3             |     P=0.194N     P=0.508N     P=0.497N     P=0.471N    |P=0.518N     P=0.492N     P=0.519      P=0.502N     |
|POLY 1.5           |     P=0.191N     P=0.505N     P=0.499N     P=0.484N    |P=0.507N     P=0.497N     P=0.510      P=0.501N     |
|POLY 6             |     P=0.198N     P=0.511N     P=0.494N     P=0.451N    |P=0.539N     P=0.483N     P=0.532      P=0.505N     |
|LOGISTIC REGRESSION|     P=0.183N     P=0.502N     P=0.499N     P=0.509N    |P=0.500N     (e)          P=0.503      (e)          |
|COCH-ARM / FISHERS |     P=0.185N     P=0.500N     P=0.500N     P=0.500N    |P=0.500N     P=0.500N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     13.2%        8.3%         7.8%         2.3%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/12 (33%)   2/16 (13%)   2/21 (10%)   1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     603          723          645          736 (T)     |696          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005N**   P=0.231N     P=0.158N     P=0.007N**  |P=0.194N     P=0.473N     P=0.494N     P=0.531N     |
|POLY 3             |     P=0.046N*    P=0.379N     P=0.345N     P=0.071N    |P=0.192N     P=0.493N     P=0.492N     P=0.503N     |
|POLY 1.5           |     P=0.057N     P=0.370N     P=0.350N     P=0.084N    |P=0.188N     P=0.497N     P=0.496N     P=0.501N     |
|POLY 6             |     P=0.033N*    P=0.387N     P=0.331N     P=0.055N    |P=0.199N     P=0.485N     P=0.487N     P=0.506N     |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.361N     P=0.324N     P=0.046N*   |P=0.184N     P=0.498N     P=0.497N     P=0.501N     |
|COCH-ARM / FISHERS |     P=0.071N     P=0.357N     P=0.357N     P=0.102N    |P=0.185N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |9/50 (18%)   12/50 (24%)  6/50 (12%)   10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     10.3%        0.0%         2.6%         0.0%        |21.1%        27.6%        13.6%        23.3%        |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    0/31 (0%)   |5/28 (18%)   10/33 (30%)  3/34 (9%)    6/28 (21%)   |
|FIRST INCIDENCE    |     396          ---          593          ---         |391          535          399          417          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.010N*    P=0.058N     P=0.138N     P=0.023N*   |P=0.430N     P=0.450      P=0.200N     P=0.499      |
|POLY 3             |     P=0.016N*    P=0.068N     P=0.177N     P=0.046N*   |P=0.419N     P=0.328      P=0.261N     P=0.508      |
|POLY 1.5           |     P=0.018N*    P=0.065N     P=0.179N     P=0.053N    |P=0.422N     P=0.311      P=0.274N     P=0.507      |
|POLY 6             |     P=0.013N*    P=0.070N     P=0.171N     P=0.037N*   |P=0.422N     P=0.362      P=0.242N     P=0.502      |
|LOGISTIC REGRESSION|     P=0.025N*    P=0.058N     P=0.186N     P=0.080N    |P=0.435N     P=0.325      P=0.298N     P=0.500      |
|COCH-ARM / FISHERS |     P=0.021N*    P=0.059N     P=0.181N     P=0.059N    |P=0.435N     P=0.312      P=0.288N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         5.2%         4.6%        |2.4%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     690          ---          617          709         |573          ---          ---          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.504N     P=0.229N     P=0.631N     P=0.435N    |P=0.623N     P=0.495N     P=0.491N     P=0.759N     |
|POLY 3             |     P=0.495      P=0.245N     P=0.685N     P=0.639N    |P=0.627N     P=0.495N     P=0.494N     P=0.758      |
|POLY 1.5           |     P=0.462      P=0.242N     P=0.689N     P=0.665N    |P=0.625N     P=0.499N     P=0.497N     P=0.760      |
|POLY 6             |     P=0.544      P=0.248N     P=0.675N     P=0.599N    |P=0.632      P=0.487N     P=0.489N     P=0.755      |
|LOGISTIC REGRESSION|     P=0.499      P=0.243N     P=0.688N     P=0.581N    |P=0.613      P=0.472N     P=0.513N     P=0.758      |
|COCH-ARM / FISHERS |     P=0.426      P=0.247N     P=0.691N     P=0.691N    |P=0.625N     P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  4/50 (8%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     25.6%        10.7%        7.6%         4.5%        |2.4%         0.0%         6.8%         2.4%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     579          544          360          561         |731          ---          451          684          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.084N     P=0.028N*    P=0.002N**  |P=0.330      P=0.468N     P=0.335      P=0.750      |
|POLY 3             |     P=0.002N**   P=0.079N     P=0.029N*    P=0.006N**  |P=0.336      P=0.492N     P=0.332      P=0.760      |
|POLY 1.5           |     P=0.003N**   P=0.076N     P=0.031N*    P=0.009N**  |P=0.341      P=0.497N     P=0.320      P=0.761      |
|POLY 6             |     P<0.001N**   P=0.082N     P=0.026N*    P=0.004N**  |P=0.326      P=0.484N     P=0.350      P=0.758      |
|LOGISTIC REGRESSION|     P=0.006N**   P=0.081N     P=0.037N*    P=0.013N*   |P=0.333      P=0.475N     P=0.282      P=0.760      |
|COCH-ARM / FISHERS |     P=0.005N**   P=0.074N     P=0.036N*    P=0.014N*   |P=0.343      P=0.500N     P=0.309      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   8/50 (16%)   4/50 (8%)    3/50 (6%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     20.5%        21.1%        9.9%         6.8%        |7.2%         2.3%         6.8%         7.2%         |
|TERMINAL (d)       |     0/12 (0%)    2/16 (13%)   0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     579          544          360          561         |543          620          451          605          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.008N**   P=0.579N     P=0.156N     P=0.022N*   |P=0.427      P=0.280N     P=0.625N     P=0.644      |
|POLY 3             |     P=0.019N*    P=0.586      P=0.156N     P=0.062N    |P=0.444      P=0.294N     P=0.636N     P=0.662      |
|POLY 1.5           |     P=0.026N*    P=0.594      P=0.164N     P=0.077N    |P=0.445      P=0.302N     P=0.647N     P=0.662      |
|POLY 6             |     P=0.012N*    P=0.583      P=0.147N     P=0.045N*   |P=0.439      P=0.280N     P=0.619N     P=0.659      |
|LOGISTIC REGRESSION|     P=0.044N*    P=0.589      P=0.184N     P=0.097N    |P=0.426      P=0.302N     P=0.638      P=0.662      |
|COCH-ARM / FISHERS |     P=0.037N*    P=0.607N     P=0.178N     P=0.100N    |P=0.442      P=0.309N     P=0.661N     P=0.661N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia Basal Cell                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/16 (0%)    2/21 (10%)   0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          736 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.572      (e)          P=0.367      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.468      (e)          P=0.241      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.425      (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.531      (e)          P=0.245      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.367      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.375      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   3/50 (6%)    4/50 (8%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     20.8%        8.1%         10.0%        2.3%        |4.8%         0.0%         6.8%         2.4%         |
|TERMINAL (d)       |     0/12 (0%)    1/16 (6%)    0/21 (0%)    0/31 (0%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     600          544          527          561         |475          ---          451          684          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004N**   P=0.101N     P=0.138N     P=0.003N**  |P=0.562      P=0.227N     P=0.525      P=0.513N     |
|POLY 3             |     P=0.006N**   P=0.104N     P=0.153N     P=0.008N**  |P=0.563      P=0.232N     P=0.526      P=0.508N     |
|POLY 1.5           |     P=0.009N**   P=0.102N     P=0.164N     P=0.011N*   |P=0.570      P=0.236N     P=0.514      P=0.504N     |
|POLY 6             |     P=0.004N**   P=0.105N     P=0.137N     P=0.005N**  |P=0.551      P=0.224N     P=0.544      P=0.514N     |
|LOGISTIC REGRESSION|     P=0.015N*    P=0.109N     P=0.176N     P=0.013N*   |P=0.553      P=0.219N     P=0.466      P=0.504N     |
|COCH-ARM / FISHERS |     P=0.013N*    P=0.100N     P=0.178N     P=0.015N*   |P=0.574N     P=0.247N     P=0.500      P=0.500N     |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     5.3%         2.7%         0.0%         4.5%        |2.4%         4.6%         2.3%         4.8%         |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    0/21 (0%)    1/31 (3%)   |0/28 (0%)    0/33 (0%)    0/34 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     603          614          ---          518         |696          620          733          572          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.349N     P=0.480N     P=0.180N     P=0.498N    |P=0.405      P=0.542      P=0.733N     P=0.480      |
|POLY 3             |     P=0.486N     P=0.512N     P=0.234N     P=0.637N    |P=0.435      P=0.517      P=0.752N     P=0.503      |
|POLY 1.5           |     P=0.494N     P=0.507N     P=0.236N     P=0.663N    |P=0.432      P=0.507      P=0.756N     P=0.502      |
|POLY 6             |     P=0.471N     P=0.515N     P=0.231N     P=0.597N    |P=0.437      P=0.534      P=0.746N     P=0.502      |
|LOGISTIC REGRESSION|     P=0.528N     P=0.500N     P=0.236N     P=0.665     |P=0.423      P=0.499      P=0.752N     P=0.497      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.247N     P=0.691N    |P=0.426      P=0.500      P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     5.3%         5.3%         10.4%        9.1%        |                                                    |
|TERMINAL (d)       |     1/12 (8%)    0/16 (0%)    2/21 (10%)   2/31 (7%)   |                                                    |
|FIRST INCIDENCE    |     733          507          702          621         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.467      P=0.663N     P=0.537      P=0.655N    |                                                    |
|POLY 3             |     P=0.247      P=0.695      P=0.347      P=0.415     |                                                    |
|POLY 1.5           |     P=0.212      P=0.694      P=0.343      P=0.378     |                                                    |
|POLY 6             |     P=0.309      P=0.692N     P=0.360      P=0.473     |                                                    |
|LOGISTIC REGRESSION|     P=0.209      P=0.688N     P=0.406      P=0.455     |                                                    |
|COCH-ARM / FISHERS |     P=0.176      P=0.691N     P=0.339      P=0.339     |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  6/50 (12%)   5/50 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     24.7%        24.1%        14.6%        11.1%       |                                                    |
|TERMINAL (d)       |     2/12 (17%)   0/16 (0%)    0/21 (0%)    1/31 (3%)   |                                                    |
|FIRST INCIDENCE    |     435          435          360          518         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.024N*    P=0.571      P=0.166N     P=0.033N*   |                                                    |
|POLY 3             |     P=0.033N*    P=0.581N     P=0.192N     P=0.084N    |                                                    |
|POLY 1.5           |     P=0.043N*    P=0.590N     P=0.197N     P=0.104N    |                                                    |
|POLY 6             |     P=0.022N*    P=0.559N     P=0.183N     P=0.060N    |                                                    |
|LOGISTIC REGRESSION|     P=0.124N     P=0.545N     P=0.217N     P=0.192N    |                                                    |
|COCH-ARM / FISHERS |     P=0.058N     P=0.598N     P=0.207N     P=0.131N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/46 (0%)    0/49 (0%)    0/47 (0%)   |0/48 (0%)    1/44 (2%)    3/48 (6%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.5%         7.3%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/15 (0%)    0/20 (0%)    0/28 (0%)   |0/26 (0%)    0/31 (0%)    3/33 (9%)    0/27 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          392          738 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.422      P=0.496      P=0.165      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.413      P=0.501      P=0.128      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.414      P=0.492      P=0.124      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.407      P=0.514      P=0.136      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.406      P=0.710      P=0.165      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.413      P=0.478      P=0.121      (e)          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/46 (2%)    0/49 (0%)    0/47 (0%)   |0/48 (0%)    0/44 (0%)    0/48 (0%)    2/47 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         3.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/15 (0%)    0/20 (0%)    0/28 (0%)   |0/26 (0%)    0/31 (0%)    0/33 (0%)    0/27 (0%)    |
|FIRST INCIDENCE    |     ---          708          ---          ---         |---          ---          ---          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.406N     P=0.520      (e)          (e)         |P=0.050      (e)          (e)          P=0.222      |
|POLY 3             |     P=0.506N     P=0.477      (e)          (e)         |P=0.058      (e)          (e)          P=0.238      |
|POLY 1.5           |     P=0.505N     P=0.481      (e)          (e)         |P=0.058      (e)          (e)          P=0.236      |
|POLY 6             |     P=0.502N     P=0.474      (e)          (e)         |P=0.060      (e)          (e)          P=0.241      |
|LOGISTIC REGRESSION|     P=0.467N     P=0.475      (e)          (e)         |P=0.055      (e)          (e)          P=0.226      |
|COCH-ARM / FISHERS |     P=0.503N     P=0.484      (e)          (e)         |P=0.057      (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  8/50 (16%)   21/50 (42%)  19/50 (38%) |16/50 (32%)  23/50 (46%)  27/50 (54%)  20/50 (40%)  |
|POLY-3 ADJUSTED (b)|     39.8%        21.1%        50.5%        42.8%       |37.8%        51.6%        60.3%        47.1%        |
|TERMINAL (d)       |     5/12 (42%)   3/16 (19%)   11/21 (52%)  16/31 (52%) |9/28 (32%)   19/33 (58%)  21/34 (62%)  15/28 (54%)  |
|FIRST INCIDENCE    |     579          507          521          619         |620          430          544          572          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.213N     P=0.042N*    P=0.567N     P=0.049N*   |P=0.168      P=0.272      P=0.113      P=0.259      |
|POLY 3             |     P=0.147      P=0.055N     P=0.220      P=0.477     |P=0.151      P=0.135      P=0.025 *    P=0.254      |
|POLY 1.5           |     P=0.107      P=0.051N     P=0.213      P=0.411     |P=0.162      P=0.117      P=0.021 *    P=0.263      |
|POLY 6             |     P=0.223      P=0.061N     P=0.234      P=0.569     |P=0.130      P=0.163      P=0.031 *    P=0.233      |
|LOGISTIC REGRESSION|     P=0.196      P=0.057N     P=0.216      P=0.551N    |P=0.148      P=0.133      P=0.030 *    P=0.235      |
|COCH-ARM / FISHERS |     P=0.077      P=0.050N     P=0.204      P=0.338     |P=0.169      P=0.109      P=0.021 *    P=0.266      |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        200 PPM      400 PPM      600 PPM     |0 PPM        200 PPM      400 PPM      600 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.7%         0.0%         4.9%         |
|TERMINAL (d)       |                                                        |0/28 (0%)    2/33 (6%)    0/34 (0%)    1/28 (4%)    |
|FIRST INCIDENCE    |                                                        |---          738 (T)      ---          692          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.236      P=0.275      (e)          P=0.226      |
|POLY 3             |                                                        |P=0.259      P=0.246      (e)          P=0.236      |
|POLY 1.5           |                                                        |P=0.254      P=0.240      (e)          P=0.237      |
|POLY 6             |                                                        |P=0.266      P=0.256      (e)          P=0.233      |
|LOGISTIC REGRESSION|                                                        |P=0.236      P=0.275      (e)          P=0.233      |
|COCH-ARM / FISHERS |                                                        |P=0.249      P=0.247      (e)          P=0.247      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).