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TDMS Study 89002-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/20/97       
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 12:37:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                       Control vs Stop Study                                                        
                                                                                                                                    

               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 002    0 PPM                                                                         
                                       INCLUDE 009    1000 PPM                                                                      
                                       INCLUDE 010    1000 PPM                                                                      
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/20/97       
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 12:37:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5         




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF PENTACHLOROPHENOL

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------

                             Adrenal Cortex                Degeneration Fatty
                             Adrenal Medulla               Hyperplasia
                             Bone Marrow                   Hyperplasia
                             Heart                         Cardiomyopathy Chronic
                                                           Thrombosis
                             Kidney                        Nephropathy Chronic
                                                           Pigmentation
                             Liver                         Basophilic Focus
                                                           Degeneration Cystic
                                                           Hepatodiaphragmatic Nodule
                                                           Hyperplasia
                                                           Inflammation Chronic
                             Lung                          Infiltration Cellular Histiocyte
                             Lymph Node                    Pigmentation Hemosiderin
                             Lymph Node, Mesenteric        Ectasia
                             Mammary Gland                 Hyperplasia Cystic
                             Mesentery                     Necrosis
                             Nose                          Fungus
                                                           Hyperplasia
                                                           Inflammation Chronic
                                                           Metaplasia
                             Preputial Gland               Inflammation Chronic
                             Prostate                      Inflammation Chronic
                             Stomach, Forestomach          Inflammation Chronic
                                                           Ulcer

              ====================================================================================================
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/20/97       
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 12:37:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5         




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF PENTACHLOROPHENOL

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------

                             Adrenal Cortex                Hyperplasia
                             Kidney                        Nephropathy Chronic
                             Nose                          Hyperplasia
                             Pituitary Gland               Cyst

              ====================================================================================================
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   1
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)              |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%                4.9%                  |          3.6%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         1/28 (4%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 565                   |          738 (T)             ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.273                |                             P=0.500N               |
|INCIDENTAL TUMOR       |                             P=0.111                |                             P=0.500N               |
|LOGISTIC REGRESSION    |                             P=0.224                |                             P=0.500N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247                |                             P=0.500N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           1/50 (2%)              |         0/50 (0%)           2/50 (4%)              |
|ADJUSTED (b)           |          8.3%                3.7%                  |          0.0%                5.8%                  |
|TERMINAL (d)           |         1/12 (8%)           1/27 (4%)              |         0/28 (0%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          736 (T)             736 (T)               |          ---                 600                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.571N               |                             P=0.250                |
|INCIDENTAL TUMOR       |                             P=0.571N               |                             P=0.240                |
|LOGISTIC REGRESSION    |                             P=0.571N               |                             P=0.238                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.753N               |                             P=0.247                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   2
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        28/50 (56%)         25/50 (50%)             |         9/50 (18%)         14/50 (28%)             |
|ADJUSTED (b)           |         84.0%               60.5%                  |         25.5%               39.9%                  |
|TERMINAL (d)           |         8/12 (67%)         12/27 (44%)             |         4/28 (14%)          8/28 (29%)             |
|FIRST INCIDENCE (DAYS) |          396                 360                   |          585                 647                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.017N*              |                             P=0.219                |
|INCIDENTAL TUMOR       |                             P=0.362N               |                             P=0.247                |
|LOGISTIC REGRESSION    |                             P=0.354N               |                             P=0.192                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.344N               |                             P=0.171                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        13/50 (26%)         17/50 (34%)             |         7/50 (14%)         17/50 (34%)             |
|ADJUSTED (b)           |         50.3%               52.9%                  |         23.7%               54.1%                  |
|TERMINAL (d)           |         4/12 (33%)         13/27 (48%)             |         6/28 (21%)         14/28 (50%)             |
|FIRST INCIDENCE (DAYS) |          564                 460                   |          698                 600                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.280N               |                             P=0.016 *              |
|INCIDENTAL TUMOR       |                             P=0.464                |                             P=0.018 *              |
|LOGISTIC REGRESSION    |                             P=0.318                |                             P=0.022 *              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.257                |                             P=0.017 *              |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   3
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           3/50 (6%)              |         1/50 (2%)           3/50 (6%)              |
|ADJUSTED (b)           |          0.0%                9.8%                  |          3.6%               10.7%                  |
|TERMINAL (d)           |         0/12 (0%)           2/27 (7%)              |         1/28 (4%)           3/28 (11%)             |
|FIRST INCIDENCE (DAYS) |          ---                 677                   |          738 (T)             738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.253                |                             P=0.304                |
|INCIDENTAL TUMOR       |                             P=0.178                |                             P=0.304                |
|LOGISTIC REGRESSION    |                             P=0.163                |                             P=0.304                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.121                |                             P=0.309                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        18/50 (36%)         28/50 (56%)             |         3/50 (6%)           4/50 (8%)              |
|ADJUSTED (b)           |         73.1%               72.1%                  |         10.7%               11.2%                  |
|TERMINAL (d)           |         6/12 (50%)         17/27 (63%)             |         3/28 (11%)          2/28 (7%)              |
|FIRST INCIDENCE (DAYS) |          647                 460                   |          738 (T)             516                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.396N               |                             P=0.509                |
|INCIDENTAL TUMOR       |                             P=0.072                |                             P=0.413                |
|LOGISTIC REGRESSION    |                             P=0.080                |                             P=0.501                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.035 *              |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   4
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           2/50 (4%)              |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          5.3%                6.4%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          715                 684                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.670                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.468                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.575                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500                |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           3/50 (6%)              |         0/50 (0%)           0/49 (0%)              |
|ADJUSTED (b)           |          5.3%                9.6%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          715                 684                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.488                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.229                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.382                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.309                |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   5
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         6/50 (12%)          2/49 (4%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |         18.8%                6.2%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         3/28 (11%)          0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          698                 708                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.127N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.098N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.124N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.141N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        30/50 (60%)         38/50 (76%)             |        11/50 (22%)         16/49 (33%)             |
|ADJUSTED (b)           |         78.2%               85.9%                  |         28.6%               35.4%                  |
|TERMINAL (d)           |         5/12 (42%)         21/27 (78%)             |         3/28 (11%)          2/28 (7%)              |
|FIRST INCIDENCE (DAYS) |          396                 360                   |          475                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.181N               |                             P=0.263                |
|INCIDENTAL TUMOR       |                             P=0.038 *              |                             P=0.182                |
|LOGISTIC REGRESSION    |                             P=0.081                |                             P=0.075                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.066                |                             P=0.168                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   6
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         4/50 (8%)           1/50 (2%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |         11.3%                3.7%                  |          0.0%                2.4%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          564                 736 (T)               |          ---                 652                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.112N               |                             P=0.520                |
|INCIDENTAL TUMOR       |                             P=0.309N               |                             P=0.548                |
|LOGISTIC REGRESSION    |                             P=0.190N               |                             P=0.503                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.181N               |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/0 (0%)            0/0 (0%)               |        10/50 (20%)         10/49 (20%)             |
|ADJUSTED (b)           |          0.0%                0.0%                  |         29.8%               35.2%                  |
|TERMINAL (d)           |         0/0                 0/0                    |         6/28 (21%)          9/27 (33%)             |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          523                 703                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.587                |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.566                |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.577N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.579                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   7
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/0 (0%)            0/0 (0%)               |         4/50 (8%)           3/49 (6%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |         10.5%                9.7%                  |
|TERMINAL (d)           |         0/0                 0/0                    |         1/28 (4%)           2/27 (7%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          544                 668                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.482N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.558N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.510N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.511N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/2 (100%)          0/0 (0%)               |         0/0 (0%)            0/0 (0%)               |
|ADJUSTED (b)           |         12.8%                0.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/0                 0/0                    |         0/0                 0/0                    |
|FIRST INCIDENCE (DAYS) |          715                 ---                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.123N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=1.000N               |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   8
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/1 (0%)            0/3 (0%)               |         2/3 (67%)           1/2 (50%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |        100.0%                2.7%                  |
|TERMINAL (d)           |         0/0                 0/1 (0%)               |         2/2 (100%)          0/1 (0%)               |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          738 (T)             701                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.667N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.686N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.737N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.700N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/1 (100%)          3/3 (100%)             |         0/3 (0%)            0/2 (0%)               |
|ADJUSTED (b)           |          2.0%              100.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/0                 1/1 (100%)             |         0/2 (0%)            0/1 (0%)               |
|FIRST INCIDENCE (DAYS) |          396                 677                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.586                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=1.000N               |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE   9
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/1 (100%)          3/3 (100%)             |         0/3 (0%)            0/2 (0%)               |
|ADJUSTED (b)           |          2.0%              100.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/0                 1/1 (100%)             |         0/2 (0%)            0/1 (0%)               |
|FIRST INCIDENCE (DAYS) |          396                 677                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.586                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=1.000N               |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        42/50 (84%)         45/50 (90%)             |        27/50 (54%)         25/50 (50%)             |
|ADJUSTED (b)           |        100.0%               97.8%                  |         66.1%               68.7%                  |
|TERMINAL (d)           |        12/12 (100%)        26/27 (96%)             |        15/28 (54%)         17/28 (61%)             |
|FIRST INCIDENCE (DAYS) |          396                 265                   |          461                 600                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.009N**             |                             P=0.386N               |
|INCIDENTAL TUMOR       |                             P=0.471                |                             P=0.463N               |
|LOGISTIC REGRESSION    |                             P=0.338                |                             P=0.390N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.277                |                             P=0.421N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  10
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         7/50 (14%)          1/50 (2%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |         40.8%                3.2%                  |          0.0%                2.5%                  |
|TERMINAL (d)           |         3/12 (25%)          0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          684                 708                   |          ---                 668                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.003N**             |                             P=0.527                |
|INCIDENTAL TUMOR       |                             P=0.028N*              |                             P=0.548                |
|LOGISTIC REGRESSION    |                             P=0.008N**             |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.030N*              |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           3/49 (6%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |          8.3%                9.5%                  |          0.0%                3.6%                  |
|TERMINAL (d)           |         1/12 (8%)           2/27 (7%)              |         0/28 (0%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          736 (T)             565                   |          ---                 738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.536                |                             P=0.500                |
|INCIDENTAL TUMOR       |                             P=0.451                |                             P=0.500                |
|LOGISTIC REGRESSION    |                             P=0.327                |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.301                |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  11
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           5/50 (10%)             |         2/50 (4%)           4/50 (8%)              |
|ADJUSTED (b)           |          2.9%               18.5%                  |          7.1%               11.1%                  |
|TERMINAL (d)           |         0/12 (0%)           5/27 (19%)             |         2/28 (7%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          643                 736 (T)               |          738 (T)             516                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.322                |                             P=0.353                |
|INCIDENTAL TUMOR       |                             P=0.251                |                             P=0.287                |
|LOGISTIC REGRESSION    |                             P=0.177                |                             P=0.338                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.102                |                             P=0.339                |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |         16.7%                0.0%                  |          0.0%                3.6%                  |
|TERMINAL (d)           |         2/12 (17%)          0/27 (0%)              |         0/28 (0%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          736 (T)             ---                   |          ---                 738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.085N               |                             P=0.500                |
|INCIDENTAL TUMOR       |                             P=0.085N               |                             P=0.500                |
|LOGISTIC REGRESSION    |                             P=0.085N               |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247N               |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  12
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           3/50 (6%)              |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |          3.6%               10.0%                  |          3.6%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           2/27 (7%)              |         1/28 (4%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          681                 684                   |          738 (T)             ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.508                |                             P=0.500N               |
|INCIDENTAL TUMOR       |                             P=0.345                |                             P=0.500N               |
|LOGISTIC REGRESSION    |                             P=0.372                |                             P=0.500N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.309                |                             P=0.500N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        50/50 (100%)        49/50 (98%)             |        44/50 (88%)         49/50 (98%)             |
|ADJUSTED (b)           |        100.0%              100.0%                  |        100.0%              100.0%                  |
|TERMINAL (d)           |        12/12 (100%)        27/27 (100%)            |        28/28 (100%)        28/28 (100%)            |
|FIRST INCIDENCE (DAYS) |          396                 360                   |          507                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.002N**             |                             P=0.326                |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.067                |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.016 *              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.056                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  13
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           2/50 (4%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |          4.2%                6.8%                  |          0.0%                3.2%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          695                 708                   |          ---                 719                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.687                |                             P=0.513                |
|INCIDENTAL TUMOR       |                             P=0.468                |                             P=0.548                |
|LOGISTIC REGRESSION    |                             P=0.579                |                             P=0.510                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500                |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        49/50 (98%)         47/50 (94%)             |        48/50 (96%)         49/50 (98%)             |
|ADJUSTED (b)           |        100.0%               95.9%                  |        100.0%              100.0%                  |
|TERMINAL (d)           |        12/12 (100%)        25/27 (93%)             |        28/28 (100%)        28/28 (100%)            |
|FIRST INCIDENCE (DAYS) |          396                 265                   |          391                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.002N**             |                             P=0.546N               |
|INCIDENTAL TUMOR       |                             P=0.321N               |                             P=0.366                |
|LOGISTIC REGRESSION    |                             P=0.347N               |                             P=0.291                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.309N               |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  14
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)              |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          8.2%                7.4%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           2/27 (7%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          647                 736 (T)               |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.481N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.655N               |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.631N               |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.691N               |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        17/50 (34%)         31/50 (62%)             |        41/50 (82%)         34/50 (68%)             |
|ADJUSTED (b)           |         87.1%               93.7%                  |         97.5%               97.1%                  |
|TERMINAL (d)           |        10/12 (83%)         25/27 (93%)             |        27/28 (96%)         27/28 (96%)             |
|FIRST INCIDENCE (DAYS) |          396                 550                   |          391                 516                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.522N               |                             P=0.088N               |
|INCIDENTAL TUMOR       |                             P=0.175                |                             P=0.170N               |
|LOGISTIC REGRESSION    |                             P=0.051                |                             P=0.058N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.004 **             |                             P=0.083N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  15
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         6/50 (12%)          9/50 (18%)             |        11/50 (22%)         16/50 (32%)             |
|ADJUSTED (b)           |         50.0%               33.3%                  |         39.3%               54.8%                  |
|TERMINAL (d)           |         6/12 (50%)          9/27 (33%)             |        11/28 (39%)         15/28 (54%)             |
|FIRST INCIDENCE (DAYS) |          736 (T)             736 (T)               |          738 (T)             690                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.267N               |                             P=0.155                |
|INCIDENTAL TUMOR       |                             P=0.267N               |                             P=0.160                |
|LOGISTIC REGRESSION    |                             P=0.267N               |                             P=0.179                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.288                |                             P=0.184                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           7/50 (14%)             |         2/50 (4%)           2/50 (4%)              |
|ADJUSTED (b)           |          9.3%               25.9%                  |          6.0%                7.1%                  |
|TERMINAL (d)           |         0/12 (0%)           7/27 (26%)             |         1/28 (4%)           2/28 (7%)              |
|FIRST INCIDENCE (DAYS) |          619                 736 (T)               |          620                 738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.356                |                             P=0.690N               |
|INCIDENTAL TUMOR       |                             P=0.229                |                             P=0.694                |
|LOGISTIC REGRESSION    |                             P=0.173                |                             P=0.686N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.080                |                             P=0.691N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  16
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           5/50 (10%)             |         9/50 (18%)         10/50 (20%)             |
|ADJUSTED (b)           |          0.0%               17.2%                  |         26.9%               26.0%                  |
|TERMINAL (d)           |         0/12 (0%)           3/27 (11%)             |         6/28 (21%)          3/28 (11%)             |
|FIRST INCIDENCE (DAYS) |          ---                 715                   |          475                 472                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.130                |                             P=0.535                |
|INCIDENTAL TUMOR       |                             P=0.051                |                             P=0.460                |
|LOGISTIC REGRESSION    |                             P=0.080                |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.028 *              |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        22/50 (44%)         34/50 (68%)             |        31/50 (62%)         36/50 (72%)             |
|ADJUSTED (b)           |         84.1%               82.0%                  |         83.1%               97.2%                  |
|TERMINAL (d)           |         9/12 (75%)         20/27 (74%)             |        22/28 (79%)         27/28 (96%)             |
|FIRST INCIDENCE (DAYS) |          396                 265                   |          507                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.449N               |                             P=0.236                |
|INCIDENTAL TUMOR       |                             P=0.129                |                             P=0.170                |
|LOGISTIC REGRESSION    |                             P=0.040 *              |                             P=0.225                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.013 *              |                             P=0.198                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  17
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           5/50 (10%)             |         7/50 (14%)          5/50 (10%)             |
|ADJUSTED (b)           |          8.3%               18.5%                  |         25.0%               17.0%                  |
|TERMINAL (d)           |         1/12 (8%)           5/27 (19%)             |         7/28 (25%)          4/28 (14%)             |
|FIRST INCIDENCE (DAYS) |          736 (T)             736 (T)               |          738 (T)             714                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.371                |                             P=0.372N               |
|INCIDENTAL TUMOR       |                             P=0.371                |                             P=0.362N               |
|LOGISTIC REGRESSION    |                             P=0.371                |                             P=0.353N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.102                |                             P=0.380N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         1/50 (2%)           2/50 (4%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |          3.1%                4.5%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          704                 472                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.526                |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.422                |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.522                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  18
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         2/50 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |          5.3%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          391                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.241N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.331N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.186N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.247N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        49/50 (98%)         46/50 (92%)             |        24/50 (48%)         18/50 (36%)             |
|ADJUSTED (b)           |        100.0%              100.0%                  |         66.2%               54.0%                  |
|TERMINAL (d)           |        12/12 (100%)        27/27 (100%)            |        16/28 (57%)         13/28 (46%)             |
|FIRST INCIDENCE (DAYS) |          396                 265                   |          585                 647                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P=0.146N               |
|INCIDENTAL TUMOR       |                             P=0.113N               |                             P=0.083N               |
|LOGISTIC REGRESSION    |                             P=0.149N               |                             P=0.085N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.181N               |                             P=0.156N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  19
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        16/50 (32%)         28/50 (56%)             |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |         60.3%               70.9%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         4/12 (33%)         16/27 (59%)             |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          576                 550                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.532                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.012 *              |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.035 *              |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.013 *              |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           2/50 (4%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |          8.3%                5.3%                  |          0.0%                2.6%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          535                 536                   |          ---                 684                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.423N               |                             P=0.522                |
|INCIDENTAL TUMOR       |                             P=0.616                |                             P=0.548                |
|LOGISTIC REGRESSION    |                             P=0.530N               |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  20
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        10/50 (20%)         13/50 (26%)             |         7/50 (14%)          9/50 (18%)             |
|ADJUSTED (b)           |         33.1%               41.3%                  |         21.1%               28.0%                  |
|TERMINAL (d)           |         1/12 (8%)          10/27 (37%)             |         3/28 (11%)          6/28 (21%)             |
|FIRST INCIDENCE (DAYS) |          396                 536                   |          645                 684                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.384N               |                             P=0.417                |
|INCIDENTAL TUMOR       |                             P=0.383                |                             P=0.482                |
|LOGISTIC REGRESSION    |                             P=0.325                |                             P=0.436                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.318                |                             P=0.393                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte Centrilobular                                                                                                  |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)              |         0/50 (0%)           2/50 (4%)              |
|ADJUSTED (b)           |          8.8%                5.3%                  |          0.0%                5.9%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          617                 502                   |          ---                 704                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.588N               |                             P=0.257                |
|INCIDENTAL TUMOR       |                             P=0.471                |                             P=0.290                |
|LOGISTIC REGRESSION    |                             P=0.678                |                             P=0.243                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.691N               |                             P=0.247                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  21
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte Centrilobular                                                                                                  |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)              |         2/50 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |         14.4%                5.1%                  |          4.3%                0.0%                  |
|TERMINAL (d)           |         1/12 (8%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          729                 502                   |          391                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.520N               |                             P=0.237N               |
|INCIDENTAL TUMOR       |                             P=0.628                |                             P=0.366N               |
|LOGISTIC REGRESSION    |                             P=0.696                |                             P=0.142N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.691N               |                             P=0.247N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           6/50 (12%)             |        12/50 (24%)         15/50 (30%)             |
|ADJUSTED (b)           |         10.3%               20.8%                  |         34.1%               47.1%                  |
|TERMINAL (d)           |         0/12 (0%)           5/27 (19%)             |         7/28 (25%)         12/28 (43%)             |
|FIRST INCIDENCE (DAYS) |          396                 684                   |          523                 516                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.547                |                             P=0.352                |
|INCIDENTAL TUMOR       |                             P=0.328                |                             P=0.274                |
|LOGISTIC REGRESSION    |                             P=0.248                |                             P=0.343                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.243                |                             P=0.326                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  22
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           3/50 (6%)              |         5/50 (10%)          5/50 (10%)             |
|ADJUSTED (b)           |          8.3%                9.3%                  |         16.5%               16.5%                  |
|TERMINAL (d)           |         1/12 (8%)           2/27 (7%)              |         4/28 (14%)          4/28 (14%)             |
|FIRST INCIDENCE (DAYS) |          736 (T)             460                   |          645                 684                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.538                |                             P=0.619N               |
|INCIDENTAL TUMOR       |                             P=0.479                |                             P=0.601N               |
|LOGISTIC REGRESSION    |                             P=0.303                |                             P=0.596N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.309                |                             P=0.630N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        39/50 (78%)         44/50 (88%)             |        41/50 (82%)         46/50 (92%)             |
|ADJUSTED (b)           |         94.5%               93.5%                  |        100.0%              100.0%                  |
|TERMINAL (d)           |        10/12 (83%)         24/27 (89%)             |        28/28 (100%)        28/28 (100%)            |
|FIRST INCIDENCE (DAYS) |          396                 360                   |          461                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.034N*              |                             P=0.298                |
|INCIDENTAL TUMOR       |                             P=0.150                |                             P=0.152                |
|LOGISTIC REGRESSION    |                             P=0.176                |                             P=0.108                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.143                |                             P=0.117                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  23
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        25/34 (74%)         24/28 (86%)             |        30/35 (86%)         26/30 (87%)             |
|ADJUSTED (b)           |         87.4%               86.2%                  |         96.2%              100.0%                  |
|TERMINAL (d)           |         5/7 (71%)          13/16 (81%)             |        18/19 (95%)         13/13 (100%)            |
|FIRST INCIDENCE (DAYS) |          396                 502                   |          507                 571                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.025N*              |                             P=0.514                |
|INCIDENTAL TUMOR       |                             P=0.172                |                             P=0.592                |
|LOGISTIC REGRESSION    |                             P=0.137                |                             P=0.633N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.196                |                             P=0.600                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           6/50 (12%)             |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%               20.5%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           5/27 (19%)             |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 614                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.084                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.055                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.031 *              |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.013 *              |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  24
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           3/50 (6%)              |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%                8.5%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 360                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.201                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.257                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.108                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.121                |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/49 (0%)           2/49 (4%)              |         2/50 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%                7.4%                  |          7.1%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           2/27 (7%)              |         2/28 (7%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 736 (T)               |          738 (T)             ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.429                |                             P=0.238N               |
|INCIDENTAL TUMOR       |                             P=0.429                |                             P=0.238N               |
|LOGISTIC REGRESSION    |                             P=0.429                |                             P=0.238N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247                |                             P=0.247N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  25
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        36/49 (73%)         26/49 (53%)             |        43/50 (86%)         45/50 (90%)             |
|ADJUSTED (b)           |         88.9%               73.7%                  |         91.3%               97.8%                  |
|TERMINAL (d)           |         8/12 (67%)         18/27 (67%)             |        24/28 (86%)         27/28 (96%)             |
|FIRST INCIDENCE (DAYS) |          396                 613                   |          461                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P=0.509                |
|INCIDENTAL TUMOR       |                             P=0.024N*              |                             P=0.343                |
|LOGISTIC REGRESSION    |                             P=0.011N*              |                             P=0.353                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.029N*              |                             P=0.380                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        12/15 (80%)         11/15 (73%)             |         3/8 (38%)           3/6 (50%)              |
|ADJUSTED (b)           |        100.0%              100.0%                  |         41.2%              100.0%                  |
|TERMINAL (d)           |         3/3 (100%)          9/9 (100%)             |         2/5 (40%)           1/1 (100%)             |
|FIRST INCIDENCE (DAYS) |          593                 680                   |          391                 600                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.013N*              |                             P=0.314                |
|INCIDENTAL TUMOR       |                             P=0.407N               |                             P=0.541                |
|LOGISTIC REGRESSION    |                             P=0.542N               |                             P=0.531                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.529                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  26
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Fungus                                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        21/50 (42%)          7/50 (14%)             |         6/50 (12%)          2/50 (4%)              |
|ADJUSTED (b)           |         71.5%               20.2%                  |         15.5%                5.9%                  |
|TERMINAL (d)           |         6/12 (50%)          2/27 (7%)              |         1/28 (4%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          396                 565                   |          461                 652                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P=0.135N               |
|INCIDENTAL TUMOR       |                             P=0.009N**             |                             P=0.196N               |
|LOGISTIC REGRESSION    |                             P=0.002N**             |                             P=0.126N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.002N**             |                             P=0.134N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        25/50 (50%)         21/50 (42%)             |        13/50 (26%)          7/50 (14%)             |
|ADJUSTED (b)           |         79.1%               59.3%                  |         36.0%               19.7%                  |
|TERMINAL (d)           |         7/12 (58%)         13/27 (48%)             |         7/28 (25%)          3/28 (11%)             |
|FIRST INCIDENCE (DAYS) |          396                 565                   |          461                  11                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.007N**             |                             P=0.112N               |
|INCIDENTAL TUMOR       |                             P=0.264N               |                             P=0.075N               |
|LOGISTIC REGRESSION    |                             P=0.197N               |                             P=0.103N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.274N               |                             P=0.105N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  27
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         6/50 (12%)          4/50 (8%)              |         9/50 (18%)         10/50 (20%)             |
|ADJUSTED (b)           |         28.5%               11.0%                  |         26.4%               28.4%                  |
|TERMINAL (d)           |         1/12 (8%)           1/27 (4%)              |         5/28 (18%)          5/28 (18%)             |
|FIRST INCIDENCE (DAYS) |          617                 613                   |          523                  11                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.157N               |                             P=0.528                |
|INCIDENTAL TUMOR       |                             P=0.573N               |                             P=0.586N               |
|LOGISTIC REGRESSION    |                             P=0.321N               |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.370N               |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        24/50 (48%)         11/50 (22%)             |        10/50 (20%)          2/50 (4%)              |
|ADJUSTED (b)           |         78.8%               32.3%                  |         28.0%                5.9%                  |
|TERMINAL (d)           |         7/12 (58%)          5/27 (19%)             |         5/28 (18%)          1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          396                 565                   |          461                 652                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P=0.018N*              |
|INCIDENTAL TUMOR       |                             P=0.015N*              |                             P=0.026N*              |
|LOGISTIC REGRESSION    |                             P=0.004N**             |                             P=0.016N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.006N**             |                             P=0.014N*              |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  28
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        12/50 (24%)          5/50 (10%)             |         3/50 (6%)           0/50 (0%)              |
|ADJUSTED (b)           |         37.4%               14.5%                  |          9.0%                0.0%                  |
|TERMINAL (d)           |         1/12 (8%)           1/27 (4%)              |         1/28 (4%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          396                 565                   |          543                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.017N*              |                             P=0.125N               |
|INCIDENTAL TUMOR       |                             P=0.269N               |                             P=0.169N               |
|LOGISTIC REGRESSION    |                             P=0.067N               |                             P=0.120N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.054N               |                             P=0.121N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |         4/50 (8%)           7/50 (14%)             |
|ADJUSTED (b)           |                                                    |         12.8%               21.0%                  |
|TERMINAL (d)           |                                                    |         3/28 (11%)          4/28 (14%)             |
|FIRST INCIDENCE (DAYS) |                                                    |          573                 571                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |                             P=0.282                |
|INCIDENTAL TUMOR       |                                                    |                             P=0.287                |
|LOGISTIC REGRESSION    |                                                    |                             P=0.270                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                                                    |                             P=0.262                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  29
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        12/50 (24%)         19/50 (38%)             |        10/50 (20%)         13/50 (26%)             |
|ADJUSTED (b)           |         52.6%               54.0%                  |         30.2%               37.5%                  |
|TERMINAL (d)           |         4/12 (33%)         12/27 (44%)             |         6/28 (21%)          8/28 (29%)             |
|FIRST INCIDENCE (DAYS) |          600                 502                   |          585                 472                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.477N               |                             P=0.351                |
|INCIDENTAL TUMOR       |                             P=0.168                |                             P=0.341                |
|LOGISTIC REGRESSION    |                             P=0.163                |                             P=0.337                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.097                |                             P=0.318                |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         9/47 (19%)          7/47 (15%)             |         1/46 (2%)           1/45 (2%)              |
|ADJUSTED (b)           |         42.2%               20.3%                  |          3.1%                3.0%                  |
|TERMINAL (d)           |         3/12 (25%)          1/26 (4%)              |         0/25 (0%)           0/26 (0%)              |
|FIRST INCIDENCE (DAYS) |          681                 680                   |          704                 708                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.110N               |                             P=0.743N               |
|INCIDENTAL TUMOR       |                             P=0.565N               |                             P=0.746N               |
|LOGISTIC REGRESSION    |                             P=0.385N               |                             P=0.763N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.392N               |                             P=0.747                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  30
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         7/50 (14%)          6/50 (12%)             |        35/50 (70%)         24/50 (48%)             |
|ADJUSTED (b)           |         37.4%               19.4%                  |         86.9%               60.1%                  |
|TERMINAL (d)           |         3/12 (25%)          4/27 (15%)             |        23/28 (82%)         13/28 (46%)             |
|FIRST INCIDENCE (DAYS) |          579                 614                   |          475                 472                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.137N               |                             P=0.037N*              |
|INCIDENTAL TUMOR       |                             P=0.386N               |                             P=0.033N*              |
|LOGISTIC REGRESSION    |                             P=0.378N               |                             P=0.019N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.021N*              |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        22/50 (44%)         26/50 (52%)             |        24/50 (48%)         24/50 (48%)             |
|ADJUSTED (b)           |         74.7%               71.2%                  |         65.1%               60.3%                  |
|TERMINAL (d)           |         6/12 (50%)         17/27 (63%)             |        16/28 (57%)         13/28 (46%)             |
|FIRST INCIDENCE (DAYS) |          593                 565                   |          475                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.088N               |                             P=0.524N               |
|INCIDENTAL TUMOR       |                             P=0.387                |                             P=0.528N               |
|LOGISTIC REGRESSION    |                             P=0.483                |                             P=0.569N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.274                |                             P=0.579N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  31
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         1/50 (2%)           2/50 (4%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |          2.9%                7.1%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           2/28 (7%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          698                 738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.510                |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.528                |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.520                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.500                |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         7/50 (14%)          8/49 (16%)             |         0/0 (0%)            0/0 (0%)               |
|ADJUSTED (b)           |         44.8%               26.4%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         5/12 (42%)          6/27 (22%)             |         0/0                 0/0                    |
|FIRST INCIDENCE (DAYS) |          396                 613                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.211N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.377N               |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.580                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.483                |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  32
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        42/50 (84%)         44/49 (90%)             |         0/0 (0%)            0/0 (0%)               |
|ADJUSTED (b)           |        100.0%               97.7%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |        12/12 (100%)        26/27 (96%)             |         0/0                 0/0                    |
|FIRST INCIDENCE (DAYS) |          396                 360                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.004N**             |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.500                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.377                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.290                |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           0/49 (0%)              |         0/0 (0%)            0/0 (0%)               |
|ADJUSTED (b)           |          9.2%                0.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/0                 0/0                    |
|FIRST INCIDENCE (DAYS) |          561                 ---                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.172N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.402N               |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.249N               |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.253N               |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  33
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        38/50 (76%)         37/50 (74%)             |                                                    |
|ADJUSTED (b)           |         88.9%               92.1%                  |                                                    |
|TERMINAL (d)           |         8/12 (67%)         24/27 (89%)             |                                                    |
|FIRST INCIDENCE (DAYS) |          396                 360                   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.007N**             |                                                    |
|INCIDENTAL TUMOR       |                             P=0.401N               |                                                    |
|LOGISTIC REGRESSION    |                             P=0.486N               |                                                    |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)              |         0/50 (0%)           1/50 (2%)              |
|ADJUSTED (b)           |          0.0%                7.4%                  |          0.0%                3.6%                  |
|TERMINAL (d)           |         0/12 (0%)           2/27 (7%)              |         0/28 (0%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          ---                 736 (T)               |          ---                 738 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.429                |                             P=0.500                |
|INCIDENTAL TUMOR       |                             P=0.429                |                             P=0.500                |
|LOGISTIC REGRESSION    |                             P=0.429                |                             P=0.500                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247                |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  34
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           4/50 (8%)              |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%               14.2%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           3/27 (11%)             |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 715                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.186                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.125                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.132                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.059                |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         5/50 (10%)          6/50 (12%)             |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |         35.1%               22.2%                  |          2.9%                0.0%                  |
|TERMINAL (d)           |         4/12 (33%)          6/27 (22%)             |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          603                 736 (T)               |          696                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.244N               |                             P=0.489N               |
|INCIDENTAL TUMOR       |                             P=0.294N               |                             P=0.452N               |
|LOGISTIC REGRESSION    |                             P=0.515N               |                             P=0.498N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500                |                             P=0.500N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  35
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         4/50 (8%)           3/50 (6%)              |         9/50 (18%)          7/50 (14%)             |
|ADJUSTED (b)           |         18.1%                8.1%                  |         26.6%               16.3%                  |
|TERMINAL (d)           |         1/12 (8%)           0/27 (0%)              |         5/28 (18%)          0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          396                 614                   |          391                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.327N               |                             P=0.378N               |
|INCIDENTAL TUMOR       |                             P=0.599                |                             P=0.323N               |
|LOGISTIC REGRESSION    |                             P=0.526N               |                             P=0.385N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.393N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)              |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |         10.9%                0.0%                  |          2.4%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          690                 ---                   |          573                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.139N               |                             P=0.486N               |
|INCIDENTAL TUMOR       |                             P=0.359N               |                             P=0.500N               |
|LOGISTIC REGRESSION    |                             P=0.188N               |                             P=0.469N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247N               |                             P=0.500N               |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  36
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        10/50 (20%)          2/50 (4%)              |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |         39.7%                5.4%                  |          3.4%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          579                 265                   |          731                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.004N**             |                             P=0.507N               |
|INCIDENTAL TUMOR       |                             P=0.041N*              |                             P=0.452N               |
|LOGISTIC REGRESSION    |                             P=0.017N*              |                             P=0.489N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.014N*              |                             P=0.500N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         8/50 (16%)          4/50 (8%)              |         3/50 (6%)           4/50 (8%)              |
|ADJUSTED (b)           |         30.6%               10.7%                  |          8.5%               11.2%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           1/28 (4%)              |
|FIRST INCIDENCE (DAYS) |          579                 265                   |          543                 472                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.074N               |                             P=0.520                |
|INCIDENTAL TUMOR       |                             P=0.156N               |                             P=0.395                |
|LOGISTIC REGRESSION    |                             P=0.209N               |                             P=0.504                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.178N               |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  37
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         8/50 (16%)          1/50 (2%)              |         2/50 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |         35.1%                3.4%                  |          5.5%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          600                 715                   |          475                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.003N**             |                             P=0.246N               |
|INCIDENTAL TUMOR       |                             P=0.086N               |                             P=0.331N               |
|LOGISTIC REGRESSION    |                             P=0.009N**             |                             P=0.214N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.015N*              |                             P=0.247N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           2/50 (4%)              |         0/50 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          5.3%                6.4%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         0/12 (0%)           1/27 (4%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          715                 684                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.670                |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.468                |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.575                |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500                |                               (e)                  |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  38
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           1/50 (2%)              |         1/50 (2%)           0/50 (0%)              |
|ADJUSTED (b)           |         10.7%                3.2%                  |          2.9%                0.0%                  |
|TERMINAL (d)           |         1/12 (8%)           0/27 (0%)              |         0/28 (0%)           0/28 (0%)              |
|FIRST INCIDENCE (DAYS) |          603                 708                   |          696                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.343N               |                             P=0.489N               |
|INCIDENTAL TUMOR       |                             P=0.560N               |                             P=0.452N               |
|LOGISTIC REGRESSION    |                             P=0.485N               |                             P=0.498N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.500N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           4/50 (8%)              |                                                    |
|ADJUSTED (b)           |         14.9%               10.4%                  |                                                    |
|TERMINAL (d)           |         1/12 (8%)           0/27 (0%)              |                                                    |
|FIRST INCIDENCE (DAYS) |          733                 502                   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.550                |                                                    |
|INCIDENTAL TUMOR       |                             P=0.203                |                                                    |
|LOGISTIC REGRESSION    |                             P=0.342                |                                                    |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.339                |                                                    |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  39
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 PPM               1000 PPM              |          0 PPM               1000 PPM              |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        10/50 (20%)          8/50 (16%)             |                                                    |
|ADJUSTED (b)           |         37.0%               20.9%                  |                                                    |
|TERMINAL (d)           |         2/12 (17%)          3/27 (11%)             |                                                    |
|FIRST INCIDENCE (DAYS) |          435                 360                   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.166N               |                                                    |
|INCIDENTAL TUMOR       |                             P=0.442N               |                                                    |
|LOGISTIC REGRESSION    |                             P=0.474N               |                                                    |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.398N               |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES           |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        16/50 (32%)         17/50 (34%)             |        16/50 (32%)         17/50 (34%)             |
|ADJUSTED (b)           |         62.5%               49.0%                  |         45.2%               49.9%                  |
|TERMINAL (d)           |         5/12 (42%)         11/27 (41%)             |         9/28 (32%)         12/28 (43%)             |
|FIRST INCIDENCE (DAYS) |          579                 360                   |          620                 365                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.105N               |                             P=0.529                |
|INCIDENTAL TUMOR       |                             P=0.458N               |                             P=0.493N               |
|LOGISTIC REGRESSION    |                             P=0.580                |                             P=0.543                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500                |                             P=0.500                |
|=================================================================================================================================|
         DATE: 08/20/97                     EXPERIMENT: 89002 TEST: 02                                                 PAGE  40
                            STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL

                                                 TERMINAL SACRIFICE AT 106 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).