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TDMS Study 89002-02 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/19/97       
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 11:11:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                       Control vs Stop Study                                                        
                                                                                                                                    

               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 002    0 PPM                                                                         
                                       INCLUDE 009    1000 PPM                                                                      
                                       INCLUDE 010    1000 PPM                                                                      
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/19/97      
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 11:11:38      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002      
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5        
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      396   396   420   435   535   561   564   576   579   593                 |
 |      600   600   603   617   619   643   645   646   647   660                 |
 |      663   675   681   684   684   690   695   698   698   702                 |
 |      703   715   715   722   724   729   733   733                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      265   360   460   502   536   550   565   592   613   614                 |
 |      661   675   677   680   684   698   698   702   702   708                 |
 |      711   715   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  94.0  92.0  90.0  74.0  58.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |   100.0 100.0  98.0  96.0  96.0  94.0  90.0  84.0  78.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0 PPM                     1000 PPM              |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       24.0%                     54.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.006N                  P=0.006N              |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       631.0                     612.7                 |
 |NATURAL DEATHS (C)      |       (15.2)                    (25.3)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       656.2                     679.3                 |
 |(STANDARD ERROR)        |       (13.2)                    (14.5)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 738 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      391   461   475   507   523   543   544   569   573   585                 |
 |      620   645   648   663   663   696   698   698   704   705                 |
 |      715   731                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      11    365   472   516   571   592   600   600   647   652                 |
 |      668   684   690   701   703   704   704   708   714   719                 |
 |      719   724                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 738 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   738 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  98.0  94.0  86.0  80.0  70.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |    98.0  98.0  98.0  96.0  96.0  94.0  92.0  84.0  80.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0 PPM                     1000 PPM              |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%                     56.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.964N                  P=0.964N              |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       607.1                     612.0                 |
 |NATURAL DEATHS (C)      |       (20.5)                    (34.8)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       680.4                     682.6                 |
 |(STANDARD ERROR)        |       (12.9)                    (17.5)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                         PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        1000 PPM         = 2

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                         2                    1
      |                                           2              2
      |                                                          2     1  1  1   2     2
      |                                                                      1         2     1
   90 +                                                                                      1 2 1
      |                                                                                        2 2
      |                                                                                          1 1  2  2
      |                                                                                            1  1
P  80 +                                                                                               11 2       2
E     |                                                                                                          2 2
R     |                                                                                                11 1        22
C     |
E  70 +                                                                                                   1  1      2 2
N     |                                                                                                      11
T     |                                                                                                               22
      |                                                                                                       1  1     22
S  60 +
U     |                                                                                                          1 1    22
R     |                                                                                                            11    22  2
V     |
I  50 +                                                                                                             11
V     |                                                                                                              11
A     |
L     |                                                                                                               11
   40 +
      |                                                                                                                1 1
      |                                                                                                                  11
      |
   30 +                                                                                                                   1 1
      |
      |                                                                                                                     11
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.
                                                         PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        1000 PPM         = 2

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1 2                                                           1
      |
      |   2                                                       2   1          1
      |
   96 +                                                           2              1 1
      |
      |                                                                            1    12
      |
   92 +                                                                                 12 1      2
      |
      |                                                                                    1  1   2   2
      |
   88 +                                                                                               22
      |
P     |                                                                                       1   1
E     |
R  84 +                                                                                                2      2
C     |
E     |                                                                                           1 1         22
N     |
T  80 +                                                                                             1     1    2  2
      |
S     |                                                                                                   1   1   2 2
U     |
R  76 +                                                                                                             22
V     |
I     |                                                                                                       1  1   2 2
V     |
A  72 +
L     |
      |                                                                                                          1    1
      |
   68 +
      |
      |                                                                                                                22
      |
   64 +                                                                                                               11
      |
      |                                                                                                                 22
      |
   60 +                                                                                                                1 1
      |
      |                                                                                                                  12 1
      |
   56 +                                                                                                                   2 11
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.