TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/19/97
EXPERIMENT: 89002 TEST: 02 TIME: 11:11:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
------------------------------------------------------------------------------------------------------------------------------------
Control vs Stop Study
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 002 0 PPM
INCLUDE 009 1000 PPM
INCLUDE 010 1000 PPM
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/19/97
EXPERIMENT: 89002 TEST: 02 TIME: 11:11:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 396 396 420 435 535 561 564 576 579 593 |
| 600 600 603 617 619 643 645 646 647 660 |
| 663 675 681 684 684 690 695 698 698 702 |
| 703 715 715 722 724 729 733 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 265 360 460 502 536 550 565 592 613 614 |
| 661 675 677 680 684 698 698 702 702 708 |
| 711 715 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 94.0 92.0 90.0 74.0 58.0 24.0 |
| | |
| | |
|1000 PPM | 100.0 100.0 98.0 96.0 96.0 94.0 90.0 84.0 78.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.006N P=0.006N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.0 612.7 |
|NATURAL DEATHS (C) | (15.2) (25.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.2 679.3 |
|(STANDARD ERROR) | (13.2) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 391 461 475 507 523 543 544 569 573 585 |
| 620 645 648 663 663 696 698 698 704 705 |
| 715 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 11 365 472 516 571 592 600 600 647 652 |
| 668 684 690 701 703 704 704 708 714 719 |
| 719 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 738 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 86.0 80.0 70.0 56.0 |
| | |
| | |
|1000 PPM | 98.0 98.0 98.0 96.0 96.0 94.0 92.0 84.0 80.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.964N P=0.964N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.1 612.0 |
|NATURAL DEATHS (C) | (20.5) (34.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 680.4 682.6 |
|(STANDARD ERROR) | (12.9) (17.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1000 PPM = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 2
| 2 1 1 1 2 2
| 1 2 1
90 + 1 2 1
| 2 2
| 1 1 2 2
| 1 1
P 80 + 11 2 2
E | 2 2
R | 11 1 22
C |
E 70 + 1 1 2 2
N | 11
T | 22
| 1 1 22
S 60 +
U | 1 1 22
R | 11 22 2
V |
I 50 + 11
V | 11
A |
L | 11
40 +
| 1 1
| 11
|
30 + 1 1
|
| 11
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1000 PPM = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 2 1
|
| 2 2 1 1
|
96 + 2 1 1
|
| 1 12
|
92 + 12 1 2
|
| 1 1 2 2
|
88 + 22
|
P | 1 1
E |
R 84 + 2 2
C |
E | 1 1 22
N |
T 80 + 1 1 2 2
|
S | 1 1 2 2
U |
R 76 + 22
V |
I | 1 1 2 2
V |
A 72 +
L |
| 1 1
|
68 +
|
| 22
|
64 + 11
|
| 22
|
60 + 1 1
|
| 12 1
|
56 + 2 11
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.