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TDMS Study 89006-04 Pathology Tables

NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96
Route: GAVAGE                                                                                                     Time: 15:15:19

                                                           CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-871

       Lock Date:  11/01/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8            7            6            8                                     
    Natural Death                                      5            5            6            9                                     
    Dosing Accident                                                              2                                                  
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           36           32                                     
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (47)         (48)         (45)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Intestine Large, Colon                             (49)         (49)         (48)         (47)                                   
   Intestine Small, Jejunum                           (47)         (46)         (46)         (45)                                   
   Intestine Small, Ileum                             (47)         (46)         (46)         (45)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         9 (18%)     12 (24%)     11 (22%)     10 (20%)                               
      Hepatocellular Carcinoma, Multiple               5 (10%)      3 (6%)       3 (6%)       2 (4%)                                
      Hepatocellular Adenoma                          16 (32%)      6 (12%)     11 (22%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                 3 (6%)       4 (8%)       3 (6%)       6 (12%)                               
      Hepatocholangiocarcinoma                                                                1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
   Mesentery                                          (10)         (12)         (9)          (10)                                   
      Fibrous Histiocytoma                                          1 (8%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (10%)                               
      Histiocytic Sarcoma                                                                     1 (10%)                               
      Sarcoma                                                                    1 (11%)                                            
   Pancreas                                           (48)         (50)         (50)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)         (48)                                   
      Fat, Hemangioma                                  1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (50)         (48)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Tongue                                             (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (48)         (49)         (50)         (48)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (49)         (44)         (48)         (44)                                   
      Pars Distalis, Adenoma                           8 (16%)      7 (16%)      6 (13%)      2 (5%)                                
      Pars Intermedia, Adenoma                         2 (4%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       4 (8%)       6 (12%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (49)                                   
      Carcinoma                                                     1 (2%)       1 (2%)       1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Ovary                                              (50)         (49)         (49)         (50)                                   
      Cystadenoma                                      3 (6%)                    2 (4%)       1 (2%)                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Luteoma                                                       1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
      Endometrium, Carcinoma                           1 (2%)                                                                       
      Endometrium, Polyp Stromal                                    3 (6%)                    1 (2%)                                
   Vagina                                             (50)         (48)         (48)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma                                                    5 (10%)      4 (8%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (48)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
   Lymph Node                                         (8)          (7)          (4)          (6)                                    
      Fibrosarcoma, Metastatic, Skin                                             1 (25%)                                            
      Inguinal, Fibrosarcoma, Metastatic, Skin         1 (13%)                   1 (25%)                                            
      Mediastinal, Carcinoma, Metastatic,                                                                                           
          Uncertain Primary Site                                                              1 (17%)                               
      Renal, Hemangiosarcoma                                        1 (14%)                                                         
   Lymph Node, Mandibular                             (46)         (46)         (48)         (44)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (48)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
   Spleen                                             (49)         (49)         (49)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                  3 (6%)                    1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (47)         (46)         (48)         (48)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             3 (6%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Vulva, Squamous Cell Papilloma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (47)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       4 (8%)                    2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Carcinoma, Metastatic, Clitoral Gland                                      1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       3 (6%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma      1 (2%)                                                                       
      Mediastinum, Carcinoma, Metastatic,                                                                                           
          Uncertain Primary Site                                                              1 (2%)                                
      Mediastinum, Fibrous Histiocytoma                             1 (2%)                                                          
      Mediastinum, Osteosarcoma, Metastatic, Bone                                1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Carcinoma, Metastatic, Harderian Gland           1 (50%)                                                                      
   Harderian Gland                                    (5)          (2)          (2)          (1)                                    
      Adenoma                                          3 (60%)      2 (100%)     1 (50%)      1 (100%)                              
      Carcinoma                                        1 (20%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                               8 (16%)     12 (24%)      8 (16%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          40          41          39                                       
     Total Primary Neoplasms                           91          77          74          56                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          24          24          22                                       
     Total Benign Neoplasms                            47          33          34          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          28          33          28                                       
     Total Malignant Neoplasms                         44          44          40          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           6           3                                       
     Total Metastatic Neoplasm                          8           1          12          17                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10            3            5           10                                     
    Moribund Sacrifice                                 9           11            9            6                                     
    Dosing Accident                                                 1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           35           35           34                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (45)         (50)         (46)         (47)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Ileum                             (45)         (49)         (46)         (46)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        1 (2%)       3 (6%)       3 (6%)       4 (8%)                                
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                        15 (30%)     17 (34%)     17 (34%)     14 (28%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)       7 (14%)      1 (2%)       2 (4%)                                
      Hepatocellular Adenoma                           9 (18%)     13 (26%)     13 (26%)     13 (26%)                               
      Hepatocellular Adenoma, Multiple                10 (20%)      4 (8%)       2 (4%)       4 (8%)                                
      Hepatocholangiocarcinoma                                                   1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (3)          (5)          (1)          (1)                                    
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (20%)                                                         
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (100%)                              
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)         (47)                                   
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)         (47)                                   
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                                 2 (4%)                                
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Bilateral, Capsule, Adenoma                                   1 (2%)                                                          
      Capsule, Adenoma                                              5 (10%)      3 (6%)       2 (4%)                                
   Adrenal Medulla                                    (48)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                                 1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (47)         (43)         (48)         (43)                                   
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Bilateral, Follicular Cell, Adenoma              1 (2%)                                                                       
      Follicular Cell, Adenoma                         5 (10%)      2 (4%)       1 (2%)       5 (10%)                               
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               2 (4%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (2)          (4)          (5)          (2)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (50%)                                                                      
                                                             Page   9                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Histiocytic Sarcoma                 1 (50%)                                                                      
      Pancreatic, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                                                                   1 (50%)                               
   Lymph Node, Mesenteric                             (46)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (48)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)       2 (4%)       4 (8%)       4 (8%)                                
   Thymus                                             (42)         (45)         (46)         (42)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Hepatocellular                                                                                           
          Carcinoma, Metastatic, Liver                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      7 (14%)      5 (10%)      6 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       4 (8%)       3 (6%)                                             
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Fibrosarcoma                                                  1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      3 (6%)       1 (2%)       3 (6%)                                
                                                             Page  10                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)                                                 
      External Ear, Histiocytic Sarcoma                                          1 (100%)                                           
   Eye                                                (1)          (6)                       (2)                                    
      Retrobulbar, Fibrosarcoma                                     1 (17%)                                                         
   Harderian Gland                                    (4)          (9)          (4)          (4)                                    
      Adenoma                                          3 (75%)      9 (100%)     3 (75%)      4 (100%)                              
      Carcinoma                                                                  1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Carcinoma, Metastatic, Liver                                                            1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Lymphoma Malignant                               2 (4%)       3 (6%)       6 (12%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 89006-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 07/12/96  
Route: GAVAGE                                                                                                     Time: 15:15:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          44          40          43                                       
     Total Primary Neoplasms                           67          91          73          71                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          30          26          31                                       
     Total Benign Neoplasms                            37          45          31          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          34          29          26                                       
     Total Malignant Neoplasms                         30          46          42          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           5           2           5                                       
     Total Metastatic Neoplasm                          7          16           2           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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                             ----------              END OF REPORT             ----------                                           
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