National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5827

TDMS Study 89006-06 Pathology Tables

NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96
Route: GAVAGE                                                                                                     Time: 12:48:52

                                                        TWO-YEAR CHRONIC




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-87-1

       Lock Date:  06/04/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            5            9            7                                     
    Natural Death                                     11            6            7           11                                     
    Dosing Accident                                                              2            1                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           38           31           31                                     
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (44)         (49)         (45)                                   
   Intestine Large, Rectum                            (46)         (48)         (46)         (45)                                   
      Squamous Cell Carcinoma, Metastatic, Vagina                                             1 (2%)                                
   Intestine Small, Jejunum                           (46)         (46)         (44)         (42)                                   
   Intestine Small, Ileum                             (46)         (44)         (45)         (42)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                               2 (4%)                                                          
      Hepatoblastoma                                   1 (2%)                                 2 (4%)                                
      Hepatocellular Carcinoma                        10 (20%)     14 (28%)     10 (20%)     11 (22%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       3 (6%)       1 (2%)       4 (8%)                                
      Hepatocellular Adenoma                          14 (28%)     11 (22%)      9 (18%)     19 (38%)                               
      Hepatocellular Adenoma, Multiple                 6 (12%)      7 (14%)      8 (16%)      9 (18%)                               
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Mesentery                                          (13)         (17)         (8)          (11)                                   
      Carcinoma, Metastatic, Pancreas                  1 (8%)                                                                       
      Carcinoma, Metastatic, Uterus                                 1 (6%)                                                          
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (8%)                                                                       
      Histiocytic Sarcoma                                           1 (6%)       1 (13%)                                            
      Sarcoma                                          2 (15%)                                                                      
      Sarcoma, Metastatic, Pancreas                                                           1 (9%)                                
   Pancreas                                           (50)         (49)         (49)         (48)                                   
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma                                                                                 1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (49)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          3 (6%)       3 (6%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (49)         (49)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Pancreas                                                           1 (2%)                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Capsule, Carcinoma, Metastatic, Uterus                        1 (2%)                                                          
      Capsule, Fibrosarcoma, Metastatic, Skeletal                                                                                   
          Muscle                                       1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (50)         (47)                                   
      Adenoma                                                       2 (4%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (46)         (49)         (46)         (46)                                   
      Pars Distalis, Adenoma                           2 (4%)       5 (10%)      1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         3 (6%)       2 (4%)       4 (8%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (1)                                                 
   Tissue NOS                                                                                (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (49)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
   Ovary                                              (50)         (50)         (47)         (48)                                   
      Cystadenoma                                      2 (4%)       2 (4%)       3 (6%)                                             
      Granulosa Cell Tumor Benign                                   2 (4%)                                                          
      Hemangioma                                                                              1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Teratoma Benign                                  1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
      Endometrium, Carcinoma                                        1 (2%)       1 (2%)                                             
      Endometrium, Polyp Stromal                       1 (2%)       2 (4%)                                                          
      Endometrium, Sarcoma Stromal                                                            1 (2%)                                
   Vagina                                             (50)         (49)         (45)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Carcinoma                                                    5 (11%)      9 (18%)                               
      Squamous Cell Papilloma                                                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (7)          (5)          (7)          (10)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (10%)                               
      Iliac, Histiocytic Sarcoma                                    1 (20%)                                                         
      Inguinal, Carcinoma, Metastatic, Clitoral                                                                                     
          Gland                                                                               1 (10%)                               
      Inguinal, Histiocytic Sarcoma                                 1 (20%)                                                         
      Mediastinal, Histiocytic Sarcoma                                           1 (14%)                                            
      Renal, Carcinoma, Metastatic, Clitoral Gland                                            1 (10%)                               
      Renal, Histiocytic Sarcoma                                                 1 (14%)                                            
   Lymph Node, Mandibular                             (50)         (46)         (48)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (47)         (48)         (47)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Spleen                                             (49)         (48)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Sarcoma, Metastatic, Pancreas                                                           1 (2%)                                
   Thymus                                             (48)         (46)         (49)         (46)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)         (50)                                   
      Trichoepithelioma                                1 (2%)                                                                       
      Pinna, Squamous Cell Carcinoma                                             1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Fibrosarcoma                                     1 (2%)                                                                       
      Hemangiosarcoma                                                                         1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Pancreas                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       3 (6%)       2 (4%)       7 (14%)                               
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       5 (10%)                   4 (8%)                                
      Carcinoma, Metastatic, Clitoral Gland                                                   1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                 1 (2%)                                
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                                          2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       4 (8%)       1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Vagina                                1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (2)          (2)          (2)                                    
      Adenoma                                          4 (80%)      2 (100%)                  1 (50%)                               
      Carcinoma                                        1 (20%)                   1 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Urethra                                                                      (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Vagina                                1 (100%)                                           
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Lymphoma Malignant                               5 (10%)     10 (20%)      7 (14%)      9 (18%)                               
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          42          41          43                                       
     Total Primary Neoplasms                           70          79          66          92                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          33          26          31                                       
     Total Benign Neoplasms                            40          41          31          42                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          30          28          35                                       
     Total Malignant Neoplasms                         30          38          35          50                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           4           3           9                                       
     Total Metastatic Neoplasm                          8          12           3          15                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     12            6            9            4                                     
    Moribund Sacrifice                                 6            9            9            4                                     
    Accidently Killed                                                            2                                                  
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           35           29           42                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Gallbladder                                        (41)         (42)         (46)         (44)                                   
   Intestine Large, Cecum                             (47)         (48)         (45)         (49)                                   
   Intestine Small, Duodenum                          (48)         (48)         (47)         (47)                                   
   Intestine Small, Jejunum                           (47)         (48)         (45)         (47)                                   
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)                                             
   Intestine Small, Ileum                             (47)         (48)         (45)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                       2 (4%)                    1 (2%)       1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        5 (10%)      2 (4%)       1 (2%)       2 (4%)                                
      Hepatoblastoma                                   1 (2%)       2 (4%)       5 (10%)      2 (4%)                                
      Hepatoblastoma, Multiple                                                   1 (2%)                                             
      Hepatocellular Carcinoma                        17 (34%)     15 (30%)     15 (30%)     15 (30%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)      11 (22%)      7 (14%)      4 (8%)                                
      Hepatocellular Adenoma                          17 (34%)     19 (38%)     14 (28%)     21 (42%)                               
      Hepatocellular Adenoma, Multiple                 8 (16%)      4 (8%)       9 (18%)      5 (10%)                               
      Hepatocholangiocarcinoma                                      1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Mesentery                                          (1)          (4)          (5)          (2)                                    
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (20%)                                            
      Sarcoma                                                                    1 (20%)                                            
   Pancreas                                           (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (50)         (48)         (49)         (50)                                   
   Stomach, Glandular                                 (50)         (48)         (49)         (50)                                   
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Capsule, Adenoma                                 5 (10%)      3 (6%)       1 (2%)       2 (4%)                                
   Adrenal Medulla                                    (50)         (49)         (48)         (49)                                   
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (48)         (50)                                   
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                                          
      Follicular Cell, Adenoma                         2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (100%)                                                        
   Tissue NOS                                         (1)                       (1)                                                 
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Preputial Gland                                    (48)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Prostate                                           (50)         (49)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Testes                                             (50)         (49)         (50)         (50)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node                                         (6)          (7)          (5)          (1)                                    
      Mediastinal, Sarcoma, Metastatic, Skin           1 (17%)                                                                      
      Popliteal, Hemangiosarcoma                       1 (17%)                                                                      
      Renal, Histiocytic Sarcoma                                    1 (14%)                                                         
   Lymph Node, Mandibular                             (49)         (48)         (49)         (50)                                   
   Lymph Node, Mesenteric                             (48)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Spleen                                             (50)         (49)         (48)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
   Thymus                                             (41)         (44)         (41)         (35)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Chondrosarcoma                           1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Rhabdomyosarcoma                                                                        1 (2%)                                
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Cranial Nerve, Schwannoma Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)      6 (12%)      9 (18%)      8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           4 (8%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                                2 (4%)                                
      Hepatoblastoma, Metastatic, Liver                                          2 (4%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      2 (4%)       4 (8%)       3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
   Nose                                               (50)         (50)         (49)         (50)                                   
      Schwannoma Malignant, Metastatic, Brain                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (7)          (2)          (10)                                   
      Adenoma                                          3 (100%)     2 (29%)      2 (100%)    10 (100%)                              
      Carcinoma                                                     3 (43%)                                                         
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Renal Tubule, Adenoma                                                                   3 (6%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Lymphoma Malignant                               1 (2%)       6 (12%)      7 (14%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 89006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                AZT                                            Date: 05/31/96  
Route: GAVAGE                                                                                                     Time: 12:48:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          49          45          50                                       
     Total Primary Neoplasms                           90          96          91          88                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          31          29          42                                       
     Total Benign Neoplasms                            49          42          42          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          40          39          29                                       
     Total Malignant Neoplasms                         41          54          49          37                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           3           9           3                                       
     Total Metastatic Neoplasm                         13           3          22           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.