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TDMS Study 89006-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                       AZT                                          DATE: 06/03/96       
EXPERIMENT: 89006 TEST: 06                                                                                     TIME: 19:43:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-85225                              ROUTE: GAVAGE                                                  NTP C#: C88072       
PATHOLOGIST: R.B. THOMPSON                                                                                     CAS: 30516-87-1      
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                                                          TWO-YEAR CHRONIC                                                          
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                       AZT                                          DATE: 06/03/96       
EXPERIMENT: 89006 TEST: 06                                                                                     TIME: 19:43:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85225                              ROUTE: GAVAGE                                                  NTP C#: C88072       
PATHOLOGIST: R.B. THOMPSON                                                                                     CAS: 30516-87-1      


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                       AZT                                          DATE: 06/03/96       
EXPERIMENT: 89006 TEST: 06                                                                                     TIME: 19:43:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85225                              ROUTE: GAVAGE                                                  NTP C#: C88072       
PATHOLOGIST: R.B. THOMPSON                                                                                     CAS: 30516-87-1      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                             IN THE ANALYSIS OF THE STUDY OF 1  AZT
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatoblastoma
              All Organs                    Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
                                             Cell Type
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Thyroid Gland: Follicular Cell
                                            Carcinoma or Adenoma
              Vagina                        Squamous Cell Carcinoma
                                            Squamous Cell Papilloma
              All Organs                    Malignant Tumors
              ====================================================================================================
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   1
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   4/49 (8%)    1/49 (2%)    2/49 (4%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  14.9%        11.8%         3.4%         4.9%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  4/32 (13%)   4/34 (12%)   1/29 (3%)    2/41 (5%)  |  0/34 (0%)    0/38 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   698          729 (T)      729 (T)      729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073N     P=0.464N     P=0.131N     P=0.136N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.082N     P=0.477N     P=0.123N     P=0.176N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.083N     P=0.479N     P=0.126N     P=0.161N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.118N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.513N     P=0.107N     P=0.226N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)   10/50 (20%) |  4/50 (8%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   9.4%         5.7%         6.3%        23.1%      |  11.8%         5.1%         0.0%         3.2%      |
|TERMINAL (d)           |  3/32 (9%)    2/35 (6%)    1/29 (3%)    9/42 (21%) |  4/34 (12%)   2/39 (5%)    0/31 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      667          612       |   731 (T)      731 (T)      ---          731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.016 *    P=0.459N     P=0.546N     P=0.096    |  P=0.107N     P=0.275N     P=0.074N     P=0.207N   |
|INCIDENTAL TUMOR       |  P=0.010 **   P=0.459N     P=0.536N     P=0.071    |  P=0.107N     P=0.275N     P=0.074N     P=0.207N   |
|LOGISTIC REGRESSION    |  P=0.009 **   P=0.459N     P=0.546N     P=0.059    |  P=0.107N     P=0.275N     P=0.074N     P=0.207N   |
|COCHRAN-ARMITAGE       |  P=0.004 **                                        |  P=0.086N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.036 *  |               P=0.339N     P=0.059N     P=0.181N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   2
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         7.7%         0.0%         0.0%      |   2.9%         0.0%         2.8%         3.2%      |
|TERMINAL (d)           |  0/32 (0%)    2/35 (6%)    0/29 (0%)    0/42 (0%)  |  1/34 (3%)    0/39 (0%)    0/31 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          458          ---          ---       |   731 (T)      ---          689          731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278N     P=0.132        (e)          (e)      |  P=0.516      P=0.473N     P=0.744      P=0.741    |
|INCIDENTAL TUMOR       |  P=0.262N     P=0.134        (e)          (e)      |  P=0.556      P=0.473N     P=0.735      P=0.741    |
|LOGISTIC REGRESSION    |  P=0.321N     P=0.126        (e)          (e)      |  P=0.534      P=0.473N     P=0.747      P=0.741    |
|COCHRAN-ARMITAGE       |  P=0.311N                                          |  P=0.539                                           |
|FISHER EXACT           |               P=0.121        (e)          (e)      |               P=0.500N     P=0.753N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   2/50 (4%)   10/50 (20%) |  5/50 (10%)   2/50 (4%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   9.4%        13.3%         6.3%        23.1%      |  14.7%         5.1%         2.8%         6.5%      |
|TERMINAL (d)           |  3/32 (9%)    4/35 (11%)   1/29 (3%)    9/42 (21%) |  5/34 (15%)   2/39 (5%)    0/31 (0%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      458          667          612       |   731 (T)      731 (T)      689          731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055      P=0.399      P=0.546N     P=0.096    |  P=0.200N     P=0.163N     P=0.125N     P=0.253N   |
|INCIDENTAL TUMOR       |  P=0.039 *    P=0.400      P=0.536N     P=0.071    |  P=0.186N     P=0.163N     P=0.128N     P=0.253N   |
|LOGISTIC REGRESSION    |  P=0.027 *    P=0.355      P=0.546N     P=0.059    |  P=0.173N     P=0.163N     P=0.121N     P=0.253N   |
|COCHRAN-ARMITAGE       |  P=0.019 *                                         |  P=0.162N                                          |
|FISHER EXACT           |               P=0.357      P=0.500N     P=0.036 *  |               P=0.218N     P=0.102N     P=0.218N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   3
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.1%         5.5%         3.4%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/32 (3%)    1/35 (3%)    1/29 (3%)    0/42 (0%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      722          729 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.204N     P=0.534      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.242N     P=0.503      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.213N     P=0.524      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.247N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.753N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.1%         5.5%         3.4%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/32 (3%)    1/35 (3%)    1/29 (3%)    0/42 (0%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      722          729 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.204N     P=0.534      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.242N     P=0.503      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.213N     P=0.524      P=0.740      P=0.446N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.247N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.753N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   4
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/49 (2%)    1/49 (2%)    0/50 (0%)  |  0/49 (0%)    2/49 (4%)    1/50 (2%)    1/47 (2%)  |
|ADJUSTED (b)           |   0.0%         2.9%         3.4%         0.0%      |   0.0%         5.1%         2.7%         3.0%      |
|TERMINAL (d)           |  0/32 (0%)    1/35 (3%)    1/29 (3%)    0/42 (0%)  |  0/34 (0%)    2/39 (5%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      729 (T)      ---       |   ---          731 (T)      674          721       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.540N     P=0.518      P=0.480        (e)      |  P=0.469      P=0.269      P=0.490      P=0.483    |
|INCIDENTAL TUMOR       |  P=0.540N     P=0.518      P=0.480        (e)      |  P=0.525      P=0.269      P=0.473      P=0.523    |
|LOGISTIC REGRESSION    |  P=0.540N     P=0.518      P=0.480        (e)      |  P=0.483      P=0.269      P=0.503      P=0.494    |
|COCHRAN-ARMITAGE       |  P=0.594N                                          |  P=0.488                                           |
|FISHER EXACT           |               P=0.495      P=0.495        (e)      |               P=0.247      P=0.505      P=0.490    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/48 (0%)    0/49 (0%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         7.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    0/29 (0%)    3/42 (7%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.022 *      (e)          (e)        P=0.173    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.022 *      (e)          (e)        P=0.173    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.022 *      (e)          (e)        P=0.173    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.013 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.121    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   5
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/48 (0%)    0/49 (0%)    4/50 (8%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         9.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    0/29 (0%)    4/42 (10%) |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **     (e)          (e)        P=0.103    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.007 **     (e)          (e)        P=0.103    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.007 **     (e)          (e)        P=0.103    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.003 **                                        |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.059    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   6.3%         0.0%         3.4%         2.4%      |   0.0%         0.0%         0.0%         3.0%      |
|TERMINAL (d)           |  2/32 (6%)    0/35 (0%)    1/29 (3%)    1/42 (2%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          729 (T)      729 (T)   |   ---          ---          ---          721       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.427N     P=0.219N     P=0.535N     P=0.405N   |  P=0.184        (e)          (e)        P=0.483    |
|INCIDENTAL TUMOR       |  P=0.427N     P=0.219N     P=0.535N     P=0.405N   |  P=0.275        (e)          (e)        P=0.564    |
|LOGISTIC REGRESSION    |  P=0.427N     P=0.219N     P=0.535N     P=0.405N   |  P=0.197        (e)          (e)        P=0.502    |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.198                                           |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.500N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   6
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   4/50 (8%)    4/50 (8%)    3/50 (6%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.5%        11.0%        12.8%         6.4%      |   0.0%         5.1%         0.0%         0.0%      |
|TERMINAL (d)           |  0/32 (0%)    3/35 (9%)    3/29 (10%)   1/42 (2%)  |  0/34 (0%)    2/39 (5%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   570          711          639          513       |   ---          731 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.160N     P=0.350N     P=0.440N     P=0.209N   |  P=0.435N     P=0.269        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.345N     P=0.599N     P=0.501N     P=0.668N   |  P=0.435N     P=0.269        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.301N     P=0.359N     P=0.435N     P=0.536N   |  P=0.435N     P=0.269        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.208N                                          |  P=0.405N                                          |
|FISHER EXACT           |               P=0.370N     P=0.370N     P=0.243N   |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    6/50 (12%)   2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   3.1%         5.7%        18.1%         4.8%      |   2.9%         0.0%         0.0%         6.2%      |
|TERMINAL (d)           |  1/32 (3%)    2/35 (6%)    3/29 (10%)   2/42 (5%)  |  1/34 (3%)    0/39 (0%)    0/31 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      638          729 (T)   |   731 (T)      ---          ---          721       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.472      P=0.531      P=0.048 *    P=0.595    |  P=0.215      P=0.473N     P=0.518N     P=0.469    |
|INCIDENTAL TUMOR       |  P=0.358      P=0.531      P=0.046 *    P=0.595    |  P=0.265      P=0.473N     P=0.518N     P=0.515    |
|LOGISTIC REGRESSION    |  P=0.407      P=0.531      P=0.044 *    P=0.595    |  P=0.236      P=0.473N     P=0.518N     P=0.495    |
|COCHRAN-ARMITAGE       |  P=0.357                                           |  P=0.246                                           |
|FISHER EXACT           |               P=0.500      P=0.056      P=0.500    |               P=0.500N     P=0.500N     P=0.500    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   7
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/50 (50%)  23/50 (46%)  23/50 (46%)  26/50 (52%) | 20/50 (40%)  18/50 (36%)  17/50 (34%)  28/50 (56%) |
|ADJUSTED (b)           |  65.2%        58.3%        66.8%        57.5%      |  53.6%        44.9%        53.1%        67.5%      |
|TERMINAL (d)           | 19/32 (59%)  19/35 (54%)  18/29 (62%)  23/42 (55%) | 17/34 (50%)  17/39 (44%)  16/31 (52%)  18/31 (58%) |
|FIRST INCIDENCE (DAYS) |   576          458          473          540       |   607          648          722          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.239N     P=0.292N     P=0.550      P=0.215N   |  P=0.010 *    P=0.234N     P=0.475N     P=0.058    |
|INCIDENTAL TUMOR       |  P=0.433N     P=0.414N     P=0.575      P=0.483N   |  P=0.022 *    P=0.275N     P=0.453N     P=0.081    |
|LOGISTIC REGRESSION    |  P=0.537N     P=0.422N     P=0.574      P=0.528N   |  P=0.032 *    P=0.317N     P=0.457N     P=0.082    |
|COCHRAN-ARMITAGE       |  P=0.415                                           |  P=0.043 *                                         |
|FISHER EXACT           |               P=0.421N     P=0.421N     P=0.500    |               P=0.418N     P=0.339N     P=0.080    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/50 (42%)  26/50 (52%)  22/50 (44%)  19/50 (38%) | 12/50 (24%)  17/50 (34%)  11/50 (22%)  15/50 (30%) |
|ADJUSTED (b)           |  46.1%        61.6%        57.0%        40.4%      |  30.3%        37.6%        30.7%        40.4%      |
|TERMINAL (d)           |  8/32 (25%)  19/35 (54%)  13/29 (45%)  14/42 (33%) |  8/34 (24%)  11/39 (28%)   7/31 (23%)  10/31 (32%) |
|FIRST INCIDENCE (DAYS) |   425          350          505          584       |   470          527          556          556       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.091N     P=0.345      P=0.358      P=0.192N   |  P=0.309      P=0.314      P=0.588N     P=0.273    |
|INCIDENTAL TUMOR       |  P=0.385N     P=0.134      P=0.424      P=0.428    |  P=0.394      P=0.112      P=0.501      P=0.243    |
|LOGISTIC REGRESSION    |  P=0.256N     P=0.211      P=0.422      P=0.521N   |  P=0.411      P=0.159      P=0.544N     P=0.325    |
|COCHRAN-ARMITAGE       |  P=0.250N                                          |  P=0.426                                           |
|FISHER EXACT           |               P=0.212      P=0.500      P=0.419N   |               P=0.189      P=0.500N     P=0.326    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   8
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/50 (42%)  27/50 (54%)  26/50 (52%)  19/50 (38%) | 13/50 (26%)  17/50 (34%)  11/50 (22%)  16/50 (32%) |
|ADJUSTED (b)           |  46.1%        64.0%        64.6%        40.4%      |  33.0%        37.6%        30.7%        43.2%      |
|TERMINAL (d)           |  8/32 (25%)  20/35 (57%)  15/29 (52%)  14/42 (33%) |  9/34 (26%)  11/39 (28%)   7/31 (23%)  11/31 (35%) |
|FIRST INCIDENCE (DAYS) |   425          350          505          584       |   470          527          556          556       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.091N     P=0.289      P=0.153      P=0.192N   |  P=0.288      P=0.396      P=0.503N     P=0.271    |
|INCIDENTAL TUMOR       |  P=0.409N     P=0.097      P=0.134      P=0.428    |  P=0.368      P=0.168      P=0.590      P=0.241    |
|LOGISTIC REGRESSION    |  P=0.260N     P=0.157      P=0.140      P=0.521N   |  P=0.390      P=0.225      P=0.455N     P=0.329    |
|COCHRAN-ARMITAGE       |  P=0.259N                                          |  P=0.406                                           |
|FISHER EXACT           |               P=0.158      P=0.212      P=0.419N   |               P=0.257      P=0.408N     P=0.330    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/50 (72%)  39/50 (78%)  34/50 (68%)  39/50 (78%) | 27/50 (54%)  29/50 (58%)  23/50 (46%)  36/50 (72%) |
|ADJUSTED (b)           |  76.5%        88.5%        84.7%        79.6%      |  65.2%        63.0%        63.6%        85.3%      |
|TERMINAL (d)           | 21/32 (66%)  30/35 (86%)  23/29 (79%)  32/42 (76%) | 20/34 (59%)  22/39 (56%)  18/31 (58%)  25/31 (81%) |
|FIRST INCIDENCE (DAYS) |   425          350          473          540       |   470          527          556          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.160N     P=0.543      P=0.469      P=0.236N   |  P=0.018 *    P=0.478N     P=0.443N     P=0.038 *  |
|INCIDENTAL TUMOR       |  P=0.452      P=0.257      P=0.580N     P=0.241    |  P=0.028 *    P=0.389      P=0.501N     P=0.027 *  |
|LOGISTIC REGRESSION    |  P=0.487      P=0.301      P=0.580N     P=0.341    |  P=0.040 *    P=0.463      P=0.394N     P=0.046 *  |
|COCHRAN-ARMITAGE       |  P=0.372                                           |  P=0.053                                           |
|FISHER EXACT           |               P=0.322      P=0.414N     P=0.322    |               P=0.420      P=0.274N     P=0.048 *  |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE   9
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/50 (72%)  39/50 (78%)  36/50 (72%)  39/50 (78%) | 27/50 (54%)  29/50 (58%)  23/50 (46%)  36/50 (72%) |
|ADJUSTED (b)           |  76.5%        88.5%        87.6%        79.6%      |  65.2%        63.0%        63.6%        85.3%      |
|TERMINAL (d)           | 21/32 (66%)  30/35 (86%)  24/29 (83%)  32/42 (76%) | 20/34 (59%)  22/39 (56%)  18/31 (58%)  25/31 (81%) |
|FIRST INCIDENCE (DAYS) |   425          350          473          540       |   470          527          556          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.165N     P=0.543      P=0.341      P=0.236N   |  P=0.018 *    P=0.478N     P=0.443N     P=0.038 *  |
|INCIDENTAL TUMOR       |  P=0.418      P=0.257      P=0.413      P=0.241    |  P=0.028 *    P=0.389      P=0.501N     P=0.027 *  |
|LOGISTIC REGRESSION    |  P=0.468      P=0.301      P=0.404      P=0.341    |  P=0.040 *    P=0.463      P=0.394N     P=0.046 *  |
|COCHRAN-ARMITAGE       |  P=0.350                                           |  P=0.053                                           |
|FISHER EXACT           |               P=0.322      P=0.588N     P=0.322    |               P=0.420      P=0.274N     P=0.048 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/50 (24%)   7/50 (14%)  11/50 (22%)   8/50 (16%) |  3/49 (6%)    3/50 (6%)    2/50 (4%)    7/50 (14%) |
|ADJUSTED (b)           |  33.2%        19.1%        32.8%        18.6%      |   7.6%         7.7%         5.3%        21.5%      |
|TERMINAL (d)           |  9/32 (28%)   6/35 (17%)   7/29 (24%)   7/42 (17%) |  1/34 (3%)    3/39 (8%)    1/31 (3%)    6/31 (19%) |
|FIRST INCIDENCE (DAYS) |   565          624          584          694       |   647          731 (T)      288          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.146N     P=0.118N     P=0.572      P=0.093N   |  P=0.057      P=0.611N     P=0.538N     P=0.140    |
|INCIDENTAL TUMOR       |  P=0.267N     P=0.176N     P=0.574      P=0.189N   |  P=0.091      P=0.635      P=0.346N     P=0.170    |
|LOGISTIC REGRESSION    |  P=0.228N     P=0.150N     P=0.592N     P=0.172N   |  P=0.082      P=0.649N     P=0.415N     P=0.164    |
|COCHRAN-ARMITAGE       |  P=0.292N                                          |  P=0.083                                           |
|FISHER EXACT           |               P=0.154N     P=0.500N     P=0.227N   |               P=0.651N     P=0.490N     P=0.167    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  10
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    3/50 (6%)    4/50 (8%)  |  3/49 (6%)    5/50 (10%)   0/50 (0%)    4/50 (8%)  |
|ADJUSTED (b)           |  11.2%         5.7%        10.3%         9.3%      |   8.8%        11.6%         0.0%        10.4%      |
|TERMINAL (d)           |  2/32 (6%)    2/35 (6%)    3/29 (10%)   3/42 (7%)  |  3/34 (9%)    3/39 (8%)    0/31 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   596          729 (T)      729 (T)      695       |   731 (T)      589          ---          625       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.545N     P=0.304N     P=0.550N     P=0.514N   |  P=0.532      P=0.426      P=0.137N     P=0.480    |
|INCIDENTAL TUMOR       |  P=0.502      P=0.374N     P=0.560N     P=0.564    |  P=0.522N     P=0.455      P=0.137N     P=0.559    |
|LOGISTIC REGRESSION    |  P=0.536      P=0.335N     P=0.550N     P=0.616N   |  P=0.578N     P=0.365      P=0.137N     P=0.509    |
|COCHRAN-ARMITAGE       |  P=0.481                                           |  P=0.572N                                          |
|FISHER EXACT           |               P=0.339N     P=0.500N     P=0.643N   |               P=0.369      P=0.117N     P=0.511    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/50 (28%)   9/50 (18%)  14/50 (28%)  11/50 (22%) |  6/49 (12%)   8/50 (16%)   2/50 (4%)   11/50 (22%) |
|ADJUSTED (b)           |  38.0%        24.7%        41.9%        25.0%      |  16.0%        18.9%         5.3%        30.3%      |
|TERMINAL (d)           | 10/32 (31%)   8/35 (23%)  10/29 (34%)   9/42 (21%) |  4/34 (12%)   6/39 (15%)   1/31 (3%)    7/31 (23%) |
|FIRST INCIDENCE (DAYS) |   565          624          584          694       |   647          589          288          625       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.201N     P=0.127N     P=0.462      P=0.134N   |  P=0.101      P=0.479      P=0.169N     P=0.128    |
|INCIDENTAL TUMOR       |  P=0.366N     P=0.190N     P=0.463      P=0.312N   |  P=0.180      P=0.444      P=0.077N     P=0.177    |
|LOGISTIC REGRESSION    |  P=0.312N     P=0.163N     P=0.476      P=0.238N   |  P=0.142      P=0.405      P=0.112N     P=0.151    |
|COCHRAN-ARMITAGE       |  P=0.411N                                          |  P=0.146                                           |
|FISHER EXACT           |               P=0.171N     P=0.588N     P=0.322N   |               P=0.403      P=0.128N     P=0.154    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  11
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.4%         0.0%      |   4.7%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    1/29 (3%)    0/42 (0%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      ---       |   610          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.718        (e)        P=0.480        (e)      |  P=0.119N     P=0.227N     P=0.256N     P=0.237N   |
|INCIDENTAL TUMOR       |  P=0.718        (e)        P=0.480        (e)      |  P=0.082N     P=0.256N     P=0.197N     P=0.154N   |
|LOGISTIC REGRESSION    |  P=0.718        (e)        P=0.480        (e)      |  P=0.102N     P=0.300N     P=0.209N     P=0.220N   |
|COCHRAN-ARMITAGE       |  P=0.694                                           |  P=0.115N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    2/50 (4%)    3/47 (6%)    0/48 (0%)  |
|ADJUSTED (b)           |                                                    |   5.9%         4.7%        10.0%         0.0%      |
|TERMINAL (d)           |                                                    |  2/34 (6%)    1/39 (3%)    2/28 (7%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   731 (T)      617          713          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.251N     P=0.648N     P=0.422      P=0.274N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.207N     P=0.630N     P=0.418      P=0.274N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.221N     P=0.691N     P=0.417      P=0.274N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.213N                                          |
|FISHER EXACT           |                                                    |               P=0.691N     P=0.470      P=0.258N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  12
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor Benign                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    2/50 (4%)    0/47 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         5.0%         0.0%         0.0%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    1/39 (3%)    0/28 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          690          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.426N     P=0.261        (e)          (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.381N     P=0.202        (e)          (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.420N     P=0.246        (e)          (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.415N                                          |
|FISHER EXACT           |                                                    |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/40 (0%)    0/46 (0%)    0/42 (0%)    0/47 (0%)  |  2/46 (4%)    5/49 (10%)   1/46 (2%)    0/46 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   6.3%        12.1%         3.4%         0.0%      |
|TERMINAL (d)           |  0/25 (0%)    0/34 (0%)    0/26 (0%)    0/39 (0%)  |  2/32 (6%)    4/39 (10%)   1/29 (3%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   731 (T)      589          731 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.093N     P=0.295      P=0.535N     P=0.260N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.074N     P=0.317      P=0.535N     P=0.260N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.077N     P=0.257      P=0.535N     P=0.260N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.073N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.245      P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  13
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |
|ADJUSTED (b)           |   5.0%         2.2%         8.3%         2.4%      |   0.0%         2.6%         6.5%         5.1%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    1/29 (3%)    1/42 (2%)  |  0/34 (0%)    1/39 (3%)    2/31 (6%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   325          568          422          729 (T)   |   ---          731 (T)      731 (T)      695       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.425N     P=0.492N     P=0.465      P=0.441N   |  P=0.144      P=0.527      P=0.218      P=0.251    |
|INCIDENTAL TUMOR       |  P=0.614N     P=0.478N     P=0.662      P=0.707    |  P=0.191      P=0.527      P=0.218      P=0.307    |
|LOGISTIC REGRESSION    |  P=0.524N     P=0.421N     P=0.616      P=0.695N   |  P=0.157      P=0.527      P=0.218      P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.160                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.500      P=0.247      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |
|ADJUSTED (b)           |   2.0%         0.0%         5.5%         2.4%      |   0.0%         2.6%         6.5%         5.1%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    1/29 (3%)    1/42 (2%)  |  0/34 (0%)    1/39 (3%)    2/31 (6%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   325          ---          422          729 (T)   |   ---          731 (T)      731 (T)      695       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.539      P=0.504N     P=0.474      P=0.731N   |  P=0.144      P=0.527      P=0.218      P=0.251    |
|INCIDENTAL TUMOR       |  P=0.483      P=0.282N     P=0.709      P=0.554    |  P=0.191      P=0.527      P=0.218      P=0.307    |
|LOGISTIC REGRESSION    |  P=0.449      P=0.267N     P=0.680      P=0.553    |  P=0.157      P=0.527      P=0.218      P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.160                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.753N   |               P=0.500      P=0.247      P=0.247    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  14
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |
|ADJUSTED (b)           |   5.0%         2.2%         8.3%         2.4%      |   0.0%         2.6%         6.5%         5.1%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    1/29 (3%)    1/42 (2%)  |  0/34 (0%)    1/39 (3%)    2/31 (6%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   325          568          422          729 (T)   |   ---          731 (T)      731 (T)      695       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.425N     P=0.492N     P=0.465      P=0.441N   |  P=0.144      P=0.527      P=0.218      P=0.251    |
|INCIDENTAL TUMOR       |  P=0.614N     P=0.478N     P=0.662      P=0.707    |  P=0.191      P=0.527      P=0.218      P=0.307    |
|LOGISTIC REGRESSION    |  P=0.524N     P=0.421N     P=0.616      P=0.695N   |  P=0.157      P=0.527      P=0.218      P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.160                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.500      P=0.247      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/49 (2%)    0/48 (0%)    0/50 (0%)  |  1/49 (2%)    0/48 (0%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.7%         2.9%         0.0%         0.0%      |   2.2%         0.0%         2.4%         0.0%      |
|TERMINAL (d)           |  1/32 (3%)    1/35 (3%)    0/28 (0%)    0/42 (0%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   698          729 (T)      ---          ---       |   523          ---          612          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.089N     P=0.476N     P=0.274N     P=0.197N   |  P=0.406N     P=0.483N     P=0.753      P=0.496N   |
|INCIDENTAL TUMOR       |  P=0.105N     P=0.497N     P=0.254N     P=0.293N   |  P=0.413N     P=0.638N     P=0.751      P=0.638N   |
|LOGISTIC REGRESSION    |  P=0.095N     P=0.494N     P=0.266N     P=0.217N   |  P=0.350N     P=0.728N     P=0.709N     P=0.428N   |
|COCHRAN-ARMITAGE       |  P=0.102N                                          |  P=0.400N                                          |
|FISHER EXACT           |               P=0.508N     P=0.258N     P=0.247N   |               P=0.505N     P=0.753N     P=0.495N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  15
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    3/50 (6%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.8%         7.7%         3.2%         5.4%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    0/29 (0%)    0/42 (0%)  |  3/34 (9%)    3/39 (8%)    1/31 (3%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   731 (T)      731 (T)      731 (T)      612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.399N     P=0.599N     P=0.338N     P=0.529N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.377N     P=0.599N     P=0.338N     P=0.488N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.351N     P=0.599N     P=0.338N     P=0.498N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.343N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.661N     P=0.309N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    3/50 (6%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.8%         7.7%         3.2%         3.2%      |
|TERMINAL (d)           |  0/32 (0%)    0/35 (0%)    0/29 (0%)    0/42 (0%)  |  3/34 (9%)    3/39 (8%)    1/31 (3%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   731 (T)      731 (T)      731 (T)      731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.202N     P=0.599N     P=0.338N     P=0.338N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.202N     P=0.599N     P=0.338N     P=0.338N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.202N     P=0.599N     P=0.338N     P=0.338N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.165N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.661N     P=0.309N     P=0.309N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  16
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/49 (8%)    2/48 (4%)    1/50 (2%)  |  3/49 (6%)    2/50 (4%)    4/50 (8%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.5%        11.4%         6.5%         2.4%      |   8.1%         5.1%        12.9%         0.0%      |
|TERMINAL (d)           |  1/32 (3%)    4/35 (11%)   1/29 (3%)    1/42 (2%)  |  2/34 (6%)    2/39 (5%)    4/31 (13%)   0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   638          729 (T)      691          729 (T)   |   647          731 (T)      731 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.196N     P=0.374      P=0.657      P=0.424N   |  P=0.170N     P=0.446N     P=0.449      P=0.134N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.300      P=0.614      P=0.544N   |  P=0.155N     P=0.492N     P=0.446      P=0.114N   |
|LOGISTIC REGRESSION    |  P=0.233N     P=0.337      P=0.661      P=0.496N   |  P=0.142N     P=0.475N     P=0.460      P=0.118N   |
|COCHRAN-ARMITAGE       |  P=0.263N                                          |  P=0.132N                                          |
|FISHER EXACT           |               P=0.329      P=0.676      P=0.500N   |               P=0.490N     P=0.511      P=0.117N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/49 (8%)    2/48 (4%)    1/50 (2%)  |  4/49 (8%)    3/50 (6%)    4/50 (8%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.5%        11.4%         6.5%         2.4%      |  10.7%         7.7%        12.9%         0.0%      |
|TERMINAL (d)           |  1/32 (3%)    4/35 (11%)   1/29 (3%)    1/42 (2%)  |  2/34 (6%)    3/39 (8%)    4/31 (13%)   0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   638          729 (T)      691          729 (T)   |   647          731 (T)      731 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.196N     P=0.374      P=0.657      P=0.424N   |  P=0.088N     P=0.438N     P=0.586      P=0.077N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.300      P=0.614      P=0.544N   |  P=0.070N     P=0.519N     P=0.586      P=0.049N*  |
|LOGISTIC REGRESSION    |  P=0.233N     P=0.337      P=0.661      P=0.496N   |  P=0.068N     P=0.467N     P=0.603      P=0.061N   |
|COCHRAN-ARMITAGE       |  P=0.263N                                          |  P=0.061N                                          |
|FISHER EXACT           |               P=0.329      P=0.676      P=0.500N   |               P=0.489N     P=0.631N     P=0.056N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  17
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   2.6%         5.1%         0.0%         0.0%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    2/39 (5%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   691          731 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.204N     P=0.535      P=0.522N     P=0.490N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.182N     P=0.478      P=0.527N     P=0.436N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.192N     P=0.519      P=0.509N     P=0.500N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.188N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   2.6%         5.1%         0.0%         3.2%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    2/39 (5%)    0/31 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   691          731 (T)      ---          731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.532N     P=0.535      P=0.522N     P=0.756    |
|INCIDENTAL TUMOR       |                                                    |  P=0.496N     P=0.478      P=0.527N     P=0.736N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.507N     P=0.519      P=0.509N     P=0.761N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.500N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.500N     P=0.753N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  18
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Vagina                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    0/50 (0%)    5/50 (10%)   9/50 (18%) |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%        12.7%        26.8%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    0/39 (0%)    1/31 (3%)    7/31 (23%) |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          493          695       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P<0.001 **     (e)        P=0.031 *    P=0.002 ** |
|INCIDENTAL TUMOR       |                                                    |  P<0.001 **     (e)        P=0.027 *    P=0.003 ** |
|LOGISTIC REGRESSION    |                                                    |  P<0.001 **     (e)        P=0.037 *    P=0.002 ** |
|COCHRAN-ARMITAGE       |                                                    |  P<0.001 **                                        |
|FISHER EXACT           |                                                    |                 (e)        P=0.028 *    P=0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Vagina                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         0.0%         6.5%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    0/39 (0%)    0/31 (0%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          ---          731 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.036 *      (e)          (e)        P=0.218    |
|INCIDENTAL TUMOR       |                                                    |  P=0.036 *      (e)          (e)        P=0.218    |
|LOGISTIC REGRESSION    |                                                    |  P=0.036 *      (e)          (e)        P=0.218    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.046 *                                         |
|FISHER EXACT           |                                                    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  19
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   6.3%         2.9%         6.9%         2.4%      |   0.0%         0.0%         2.3%         5.3%      |
|TERMINAL (d)           |  2/32 (6%)    1/35 (3%)    2/29 (7%)    1/42 (2%)  |  0/34 (0%)    0/39 (0%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      729 (T)   |   ---          ---          556          666       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.358N     P=0.469N     P=0.660      P=0.405N   |  P=0.070        (e)        P=0.491      P=0.238    |
|INCIDENTAL TUMOR       |  P=0.358N     P=0.469N     P=0.660      P=0.405N   |  P=0.136        (e)        P=0.602      P=0.307    |
|LOGISTIC REGRESSION    |  P=0.358N     P=0.469N     P=0.660      P=0.405N   |  P=0.072        (e)        P=0.565      P=0.237    |
|COCHRAN-ARMITAGE       |  P=0.444N                                          |  P=0.070                                           |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500N   |                 (e)        P=0.500      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)   6/50 (12%)   4/50 (8%)    3/50 (6%)  |  1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |  16.2%        16.1%        12.8%         6.4%      |   2.2%         5.1%         2.4%         4.7%      |
|TERMINAL (d)           |  1/32 (3%)    4/35 (11%)   3/29 (10%)   1/42 (2%)  |  0/34 (0%)    2/39 (5%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   570          711          639          513       |   523          731 (T)      612          601       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.072N     P=0.460N     P=0.332N     P=0.129N   |  P=0.426      P=0.541      P=0.753      P=0.508    |
|INCIDENTAL TUMOR       |  P=0.184N     P=0.541      P=0.372N     P=0.477N   |  P=0.460      P=0.431      P=0.732      P=0.495    |
|LOGISTIC REGRESSION    |  P=0.146N     P=0.497N     P=0.250N     P=0.357N   |  P=0.459      P=0.445      P=0.714N     P=0.533    |
|COCHRAN-ARMITAGE       |  P=0.101N                                          |  P=0.444                                           |
|FISHER EXACT           |               P=0.500N     P=0.262N     P=0.159N   |               P=0.500      P=0.753N     P=0.500    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  20
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   6/50 (12%)   6/50 (12%)   4/50 (8%)  |  1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)  |
|ADJUSTED (b)           |  21.6%        16.1%        19.5%         8.7%      |   2.2%         5.1%         4.7%         9.8%      |
|TERMINAL (d)           |  3/32 (9%)    4/35 (11%)   5/29 (17%)   2/42 (5%)  |  0/34 (0%)    2/39 (5%)    0/31 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   570          711          639          513       |   523          731 (T)      556          601       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.064N     P=0.259N     P=0.372N     P=0.081N   |  P=0.109      P=0.541      P=0.487      P=0.189    |
|INCIDENTAL TUMOR       |  P=0.156N     P=0.452N     P=0.413N     P=0.301N   |  P=0.164      P=0.431      P=0.518      P=0.207    |
|LOGISTIC REGRESSION    |  P=0.101N     P=0.288N     P=0.307N     P=0.239N   |  P=0.119      P=0.445      P=0.603      P=0.189    |
|COCHRAN-ARMITAGE       |  P=0.103N                                          |  P=0.113                                           |
|FISHER EXACT           |               P=0.288N     P=0.288N     P=0.117N   |               P=0.500      P=0.500      P=0.181    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         5.3%         0.0%         0.0%      |   4.0%         2.0%         8.3%         2.7%      |
|TERMINAL (d)           |  0/32 (0%)    1/35 (3%)    0/29 (0%)    0/42 (0%)  |  0/34 (0%)    0/39 (0%)    1/31 (3%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          665          ---          ---       |   379          527          582          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.369N     P=0.255        (e)          (e)      |  P=0.486N     P=0.488N     P=0.461      P=0.499N   |
|INCIDENTAL TUMOR       |  P=0.444N     P=0.232        (e)          (e)      |  P=0.547N     P=0.712      P=0.364      P=0.676N   |
|LOGISTIC REGRESSION    |  P=0.398N     P=0.237        (e)          (e)      |  P=0.404N     P=0.319      P=0.637      P=0.396N   |
|COCHRAN-ARMITAGE       |  P=0.405N                                          |  P=0.474N                                          |
|FISHER EXACT           |               P=0.247        (e)          (e)      |               P=0.500N     P=0.500      P=0.500N   |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  21
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    6/50 (12%)   7/50 (14%)   5/50 (10%) |  5/50 (10%)  10/50 (20%)   7/50 (14%)   9/50 (18%) |
|ADJUSTED (b)           |   2.5%        13.3%        22.0%        11.5%      |  12.6%        24.0%        18.4%        25.3%      |
|TERMINAL (d)           |  0/32 (0%)    1/35 (3%)    5/29 (17%)   4/42 (10%) |  2/34 (6%)    8/39 (21%)   3/31 (10%)   6/31 (19%) |
|FIRST INCIDENCE (DAYS) |   638          257          596          612       |   603          636          219          625       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277      P=0.070      P=0.027 *    P=0.164    |  P=0.203      P=0.195      P=0.328      P=0.180    |
|INCIDENTAL TUMOR       |  P=0.097      P=0.059      P=0.021 *    P=0.070    |  P=0.372      P=0.148      P=0.600      P=0.259    |
|LOGISTIC REGRESSION    |  P=0.141      P=0.073      P=0.025 *    P=0.097    |  P=0.268      P=0.139      P=0.450      P=0.194    |
|COCHRAN-ARMITAGE       |  P=0.174                                           |  P=0.265                                           |
|FISHER EXACT           |               P=0.056      P=0.030 *    P=0.102    |               P=0.131      P=0.380      P=0.194    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  31/50 (62%)  29/50 (58%)  42/50 (84%) | 30/50 (60%)  33/50 (66%)  26/50 (52%)  31/50 (62%) |
|ADJUSTED (b)           |  78.2%        77.1%        78.0%        89.3%      |  76.7%        76.6%        69.8%        73.3%      |
|TERMINAL (d)           | 23/32 (72%)  26/35 (74%)  21/29 (72%)  37/42 (88%) | 25/34 (74%)  29/39 (74%)  20/31 (65%)  20/31 (65%) |
|FIRST INCIDENCE (DAYS) |   565          458          473          540       |   607          589          288          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.392      P=0.264N     P=0.507N     P=0.566    |  P=0.288      P=0.504N     P=0.462N     P=0.362    |
|INCIDENTAL TUMOR       |  P=0.064      P=0.487N     P=0.489N     P=0.068    |  P=0.534      P=0.567      P=0.311N     P=0.512    |
|LOGISTIC REGRESSION    |  P=0.048 *    P=0.431N     P=0.464N     P=0.075    |  P=0.535N     P=0.490      P=0.414N     P=0.534    |
|COCHRAN-ARMITAGE       |  P=0.022 *                                         |  P=0.500N                                          |
|FISHER EXACT           |               P=0.418N     P=0.268N     P=0.032 *  |               P=0.339      P=0.273N     P=0.500    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  22
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      30 MG/KG     60 MG/KG     120       |   VEHICLE      30 MG/KG     60 MG/KG     120       |
|                       |   CONTROL                                MG/KG     |   CONTROL                                MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 28/50 (56%)  40/50 (80%)  39/50 (78%)  29/50 (58%) | 26/50 (52%)  30/50 (60%)  28/50 (56%)  35/50 (70%) |
|ADJUSTED (b)           |  58.0%        80.0%        84.8%        60.4%      |  55.8%        62.5%        60.8%        77.4%      |
|TERMINAL (d)           | 12/32 (38%)  25/35 (71%)  22/29 (76%)  23/42 (55%) | 14/34 (41%)  21/39 (54%)  13/31 (42%)  21/31 (68%) |
|FIRST INCIDENCE (DAYS) |   325          257          422          513       |   379          527          219          556       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.109N     P=0.098      P=0.028 *    P=0.270N   |  P=0.044 *    P=0.500      P=0.309      P=0.071    |
|INCIDENTAL TUMOR       |  P=0.480      P=0.003 **   P=0.008 **   P=0.197    |  P=0.080      P=0.161      P=0.339      P=0.050 *  |
|LOGISTIC REGRESSION    |  P=0.512N     P=0.004 **   P=0.006 **   P=0.335    |  P=0.031 *    P=0.190      P=0.335      P=0.051    |
|COCHRAN-ARMITAGE       |  P=0.379N                                          |  P=0.051                                           |
|FISHER EXACT           |               P=0.009 **   P=0.016 *    P=0.500    |               P=0.273      P=0.421      P=0.050    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 43/50 (86%)  49/50 (98%)  45/50 (90%)  50/50 (100%)| 41/50 (82%)  42/50 (84%)  41/50 (82%)  43/50 (86%) |
|ADJUSTED (b)           |  86.0%        98.0%        97.8%       100.0%      |  85.3%        87.5%        87.2%        91.4%      |
|TERMINAL (d)           | 25/32 (78%)  34/35 (97%)  28/29 (97%)  42/42 (100%)| 27/34 (79%)  33/39 (85%)  25/31 (81%)  27/31 (87%) |
|FIRST INCIDENCE (DAYS) |   325          257          422          513       |   379          527          219          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.244N     P=0.379      P=0.206      P=0.341N   |  P=0.161      P=0.318N     P=0.345      P=0.293    |
|INCIDENTAL TUMOR       |  P=0.013 *    P=0.022 *    P=0.194      P=0.003 ** |  P=0.382      P=0.485      P=0.518      P=0.333    |
|LOGISTIC REGRESSION    |  P=0.010 *    P=0.022 *    P=0.151      P=0.003 ** |  P=0.317      P=0.480      P=0.535      P=0.382    |
|COCHRAN-ARMITAGE       |  P=0.019 *                                         |  P=0.362                                           |
|FISHER EXACT           |               P=0.030 *    P=0.380      P=0.006 ** |               P=0.500      P=0.602N     P=0.393    |
|=================================================================================================================================|
         DATE: 06/04/96                     EXPERIMENT: 89006 TEST: 06                                                 PAGE  23
                                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  AZT
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).