Share This:
https://ntp.niehs.nih.gov/go/5839

TDMS Study 89006-08 Pathology Tables

NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41




       Facility:  Southern Research Institute

       Chemical CAS #:  76543-88-9

       Lock Date:  09/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           13            9           11                                     
    Natural Death                                     12            5           15            8                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           32           25           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (50)         (48)         (49)                                   
   Intestine Large, Colon                             (47)         (50)         (50)         (49)                                   
   Intestine Large, Cecum                             (48)         (50)         (50)         (49)                                   
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
   Intestine Small, Duodenum                          (47)         (50)         (49)         (45)                                   
   Intestine Small, Jejunum                           (47)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Liver                                              (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                                                     1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma                         9 (18%)     10 (20%)     10 (20%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple               7 (14%)      2 (4%)       3 (6%)       6 (12%)                               
      Hepatocellular Adenoma                          12 (24%)     16 (32%)     12 (24%)     13 (26%)                               
      Hepatocellular Adenoma, Multiple                12 (24%)      9 (18%)     10 (20%)      9 (18%)                               
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                                   1 (2%)                                                          
   Mesentery                                          (21)         (21)         (18)         (16)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (5%)                                                                       
      Fibrosarcoma                                                                            1 (6%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (5%)                                 1 (6%)                                
      Fibrosarcoma, Metastatic, Tissue NOS                          1 (5%)                                                          
      Hemangiosarcoma                                                                         1 (6%)                                

                                                             Page   2                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hepatocellular Carcinoma, Metastatic, Liver      1 (5%)                                                                       
      Histiocytic Sarcoma                              1 (5%)       1 (5%)                                                          
      Liposarcoma                                      1 (5%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (6%)                                             
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Tissue NOS                          1 (2%)                                                          
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (48)         (49)                                   
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
   Stomach, Forestomach                               (48)         (50)         (50)         (46)                                   
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Stomach, Glandular                                 (48)         (50)         (50)         (46)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Capsule, Adenoma                                 1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)                                             
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (46)         (47)         (44)         (43)                                   
      Pars Distalis, Adenoma                          11 (24%)      8 (17%)      7 (16%)      5 (12%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          

                                                             Page   3                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Follicular Cell, Adenoma                         5 (10%)      3 (6%)       2 (4%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)                       (1)                                                 
      Fibrosarcoma, Metastatic, Skin                   1 (50%)                                                                      
   Tissue NOS                                         (1)          (1)          (2)                                                 
      Abdominal, Fibrosarcoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (47)         (49)                                   
      Hemangioma                                                                 1 (2%)                                             
   Ovary                                              (46)         (48)         (49)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Cystadenoma                                      4 (9%)       2 (4%)                    1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Teratoma Benign                                  1 (2%)                    1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                              1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Endometrium, Polyp Stromal                       1 (2%)                    1 (2%)       2 (4%)                                
      Endometrium, Sarcoma Stromal                     1 (2%)                                                                       
   Vagina                                             (48)         (50)         (47)         (46)                                   
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                                   1 (2%)                                                          
   Lymph Node                                         (12)         (13)         (9)          (11)                                   
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                         1 (8%)                                                          
      Iliac, Histiocytic Sarcoma                       1 (8%)       1 (8%)                                                          
      Inguinal, Mast Cell Tumor Malignant,                                                                                          
          Metastatic, Uncertain Primary Site                                     1 (11%)                                            

                                                             Page   4                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                              1 (8%)                                                                       
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                                           1 (9%)                                
      Mediastinal, Fibrosarcoma, Metastatic, Skin      1 (8%)                                                                       
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Tissue NOS                                                1 (8%)                                                          
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (8%)                                                                       
      Mediastinal, Liposarcoma, Metastatic,                                                                                         
          Mesentery                                    1 (8%)                                                                       
      Pancreatic, Histiocytic Sarcoma                               1 (8%)                                                          
      Renal, Histiocytic Sarcoma                       1 (8%)                    1 (11%)                                            
      Renal, Liposarcoma, Metastatic, Mesentery        1 (8%)                                                                       
   Lymph Node, Mandibular                             (49)         (49)         (47)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
   Lymph Node, Mesenteric                             (45)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
   Spleen                                             (47)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Fibrosarcoma, Metastatic, Mesentery                                                     1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
   Thymus                                             (41)         (48)         (48)         (39)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (3%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       

                                                             Page   5                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Carcinoma, Metastatic,                                                                                   
           Harderian Gland                             1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                                            1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)       2 (4%)                    2 (4%)                                
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant, Metastatic, Uncertain Primary                                                                                  
          Site                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)       1 (2%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                                                     1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Tissue NOS                          1 (2%)                                                          
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
   Spinal Cord                                        (2)          (2)          (4)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  5 (10%)      4 (8%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       4 (8%)                    7 (14%)                               
      Basal Cell Carcinoma, Metastatic, Skin           1 (2%)                                                                       
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Liposarcoma, Metastatic, Mesentery               1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinum, Mast Cell Tumor Malignant,                                                                                       
          Metastatic, Uncertain Primary Site                                     1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       

                                                             Page   6                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (8)          (4)          (3)                                    
      Adenoma                                          2 (67%)      5 (63%)      3 (75%)      3 (100%)                              
      Carcinoma                                        1 (33%)      2 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (2%)                                             
   Ureter                                                                                    (1)                                    
      Fibrosarcoma, Metastatic, Skin                                                          1 (100%)                              
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Lymphoma Malignant                              11 (22%)     13 (26%)     11 (22%)      6 (12%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   7                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          44          44                                       
     Total Primary Neoplasms                           96          92          72          84                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          32          33          31                                       
     Total Benign Neoplasms                            53          52          42          43                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          33          27          30                                       
     Total Malignant Neoplasms                         43          40          30          41                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           6           4           7                                       
     Total Metastatic Neoplasm                         36          12          17          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   8                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10           15           11           13                                     
    Moribund Sacrifice                                13            7           10           10                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           28           28           27                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (45)         (48)         (43)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Intestine Small, Duodenum                          (49)         (47)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (47)         (49)         (50)                                   
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (47)         (49)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangioma, Multiple                                                       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hemangiosarcoma, Multiple                        3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
      Hepatoblastoma                                   2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Hepatocellular Carcinoma                        10 (20%)     17 (34%)     10 (20%)     13 (26%)                               
      Hepatocellular Carcinoma, Multiple               8 (16%)      6 (12%)      4 (8%)       6 (12%)                               
      Hepatocellular Adenoma                          11 (22%)     10 (20%)     11 (22%)     14 (28%)                               
      Hepatocellular Adenoma, Multiple                 3 (6%)       4 (8%)       5 (10%)      5 (10%)                               
      Hepatocholangiocarcinoma                         1 (2%)                    1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Mesentery                                          (7)          (5)          (6)          (9)                                    
      Fibrosarcoma                                                               1 (17%)                                            
      Fibrous Histiocytoma                                          1 (20%)      1 (17%)                                            
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (14%)                   1 (17%)      1 (11%)                               
      Histiocytic Sarcoma                                                                     1 (11%)                               
   Pancreas                                           (49)         (49)         (49)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             

                                                             Page   9                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrous Histiocytoma, Metastatic, Mesentery                                1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                    1 (2%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (48)         (49)         (50)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Tooth                                              (24)         (14)         (24)         (20)                                   
      Odontoma                                                                   1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Bilateral, Capsule, Adenoma                                                1 (2%)                                             
      Capsule, Adenoma                                 1 (2%)       1 (2%)       3 (6%)       3 (6%)                                
   Adrenal Medulla                                    (49)         (49)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Pheochromocytoma Benign                                       1 (2%)                    1 (2%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (48)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
   Tissue NOS                                         (1)          (2)          (1)          (1)                                    
      Hepatoblastoma, Metastatic, Liver                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Prostate                                           (49)         (49)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Sertoli Cell, Adenoma                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               2 (4%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (3)          (3)          (6)          (3)                                    
      Iliac, Fibrous Histiocytoma                                   1 (33%)                                                         
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                              1 (17%)                                            
      Mediastinal, Fibrous Histiocytoma                             1 (33%)                                                         
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                                  1 (17%)                                            
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (33%)                   1 (17%)      1 (33%)                               
      Mediastinal, Histiocytic Sarcoma                                                        1 (33%)                               
      Pancreatic, Hepatocholangiocarcinoma,                                                                                         
          Metastatic, Liver                                                                   1 (33%)                               
      Renal, Fibrous Histiocytoma                                   1 (33%)                                                         
   Lymph Node, Mandibular                             (47)         (46)         (45)         (45)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (48)         (46)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                                1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                               5 (10%)      2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Thymus                                             (38)         (38)         (35)         (39)                                   
      Fibrous Histiocytoma                                          1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  11                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Hepatoblastoma,                                                                                          
          Metastatic, Liver                            1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)     10 (20%)      8 (16%)      5 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       4 (8%)       3 (6%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                 2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)     10 (20%)      2 (4%)       7 (14%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                    1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Mediastinum, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                              1 (2%)                                             
      Mediastinum, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                                  1 (2%)                                             
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  12                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (8)          (4)                                    
      Adenoma                                          2 (50%)      5 (83%)      4 (50%)      3 (75%)                               
      Carcinoma                                        2 (50%)      1 (17%)      1 (13%)      1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (49)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (50)         (50)                                   
      Hemangioma                                                                              1 (2%)                                
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
      Lymphoma Malignant                               4 (8%)       2 (4%)       5 (10%)      2 (4%)                                
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  13                                                               
NTP Experiment-Test: 89006-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                     INTERFERON A/INTERFERON AD                                Date: 12/23/96    
Route: SUBCUTANEOUS                                                                                               Time: 17:05:41    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      500 U        5000 U       5000 U A                                  
                                                   CONTROL      A/D          A/D                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          40          41          47                                       
     Total Primary Neoplasms                           66          94          75          70                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22          26          28          29                                       
     Total Benign Neoplasms                            29          38          39          34                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          30          25          30                                       
     Total Malignant Neoplasms                         37          56          36          36                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             10          10           5          11                                       
     Total Metastatic Neoplasm                         26          10          24          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  14                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------