National Toxicology Program

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TDMS Study 89006-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                            INTERFERON A/INTERFERON AD                              DATE: 12/30/96       
EXPERIMENT: 89006 TEST: 08                                                                                     TIME: 17:10:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-85225                              ROUTE: SUBCUTANEOUS                                            NTP C#: C89001       
PATHOLOGIST: MISSING                                                                                           CAS: 76543-88-9      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                            INTERFERON A/INTERFERON AD                              DATE: 12/30/96       
EXPERIMENT: 89006 TEST: 08                                                                                     TIME: 17:10:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85225                              ROUTE: SUBCUTANEOUS                                            NTP C#: C89001       
PATHOLOGIST: MISSING                                                                                           CAS: 76543-88-9      




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                            INTERFERON A/INTERFERON AD                              DATE: 12/30/96       
EXPERIMENT: 89006 TEST: 08                                                                                     TIME: 17:10:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85225                              ROUTE: SUBCUTANEOUS                                            NTP C#: C89001       
PATHOLOGIST: MISSING                                                                                           CAS: 76543-88-9      




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                 IN THE ANALYSIS OF THE STUDY OF 9  INTERFERON A/INTERFERON AD

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Spleen                        Hemangiosarcoma
              All Organs                    Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma

              ====================================================================================================
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   1
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/49 (2%)    4/50 (8%)    3/49 (6%)  |  1/50 (2%)    1/49 (2%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   3.7%         3.6%        12.8%        10.9%      |   3.3%         2.4%         0.0%         0.0%      |
|TERMINAL (d)           |  1/27 (4%)    1/28 (4%)    3/28 (11%)   2/26 (8%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      728 (T)      572          723       |   699          685          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.381      P=0.754N     P=0.185      P=0.302    |  P=0.462N     P=0.706N     P=0.521N     P=0.464N   |
|INCIDENTAL TUMOR       |  P=0.385      P=0.754N     P=0.201      P=0.304    |  P=0.698N     P=0.670      P=0.550N     P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.419      P=0.754N     P=0.170      P=0.312    |  P=0.489N     P=0.759      P=0.511N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.397                                           |  P=0.487N                                          |
|FISHER EXACT           |               P=0.747      P=0.181      P=0.301    |               P=0.747      P=0.500N     P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    2/49 (4%)    0/50 (0%)    1/49 (2%)  |  0/50 (0%)    0/49 (0%)    1/50 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |   2.9%         6.8%         0.0%         3.8%      |   0.0%         0.0%         4.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/28 (4%)    0/28 (0%)    1/26 (4%)  |  0/25 (0%)    0/32 (0%)    1/25 (4%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   673          667          ---          728 (T)   |   ---          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.699N     P=0.462      P=0.512N     P=0.759    |  P=0.707N       (e)        P=0.500        (e)      |
|INCIDENTAL TUMOR       |  P=0.634N     P=0.386      P=0.571N     P=0.745N   |  P=0.707N       (e)        P=0.500        (e)      |
|LOGISTIC REGRESSION    |  P=0.698N     P=0.491      P=0.496N     P=0.761N   |  P=0.707N       (e)        P=0.500        (e)      |
|COCHRAN-ARMITAGE       |  P=0.709N                                          |  P=0.728N                                          |
|FISHER EXACT           |               P=0.500      P=0.495N     P=0.753N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   2
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    2/49 (4%)    0/50 (0%)    1/49 (2%)  |  1/50 (2%)    0/49 (0%)    2/50 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |   2.9%         6.8%         0.0%         3.8%      |   2.0%         0.0%         6.7%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/28 (4%)    0/28 (0%)    1/26 (4%)  |  0/25 (0%)    0/32 (0%)    1/25 (4%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   673          667          ---          728 (T)   |   409          ---          659          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.699N     P=0.462      P=0.512N     P=0.759    |  P=0.374N     P=0.496N     P=0.486      P=0.500N   |
|INCIDENTAL TUMOR       |  P=0.634N     P=0.386      P=0.571N     P=0.745N   |  P=0.343N     P=0.638N     P=0.393      P=0.419N   |
|LOGISTIC REGRESSION    |  P=0.698N     P=0.491      P=0.496N     P=0.761N   |  P=0.374N     P=0.946N     P=0.561      P=0.335N   |
|COCHRAN-ARMITAGE       |  P=0.709N                                          |  P=0.380N                                          |
|FISHER EXACT           |               P=0.500      P=0.495N     P=0.753N   |               P=0.505N     P=0.500      P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         5.4%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    0/27 (0%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          615          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.474N     P=0.215        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.579N     P=0.280        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.514N     P=0.259        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.485N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   3
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   4/50 (8%)    3/50 (6%)  |  2/50 (4%)    5/50 (10%)   3/50 (6%)    3/50 (6%)  |
|ADJUSTED (b)           |   7.4%        17.0%        12.8%         9.5%      |   8.0%        15.6%        10.9%         8.9%      |
|TERMINAL (d)           |  2/27 (7%)    4/28 (14%)   3/28 (11%)   2/27 (7%)  |  2/25 (8%)    5/32 (16%)   2/25 (8%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      661          583          567       |   729 (T)      729 (T)      672          642       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.510N     P=0.220      P=0.345      P=0.496    |  P=0.499N     P=0.323      P=0.487      P=0.567    |
|INCIDENTAL TUMOR       |  P=0.526N     P=0.193      P=0.366      P=0.477    |  P=0.495N     P=0.323      P=0.477      P=0.648    |
|LOGISTIC REGRESSION    |  P=0.471N     P=0.190      P=0.321      P=0.505    |  P=0.556N     P=0.323      P=0.467      P=0.503    |
|COCHRAN-ARMITAGE       |  P=0.501N                                          |  P=0.562N                                          |
|FISHER EXACT           |               P=0.218      P=0.339      P=0.500    |               P=0.218      P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.6%         3.6%         3.6%         2.5%      |   3.0%         5.2%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/28 (4%)    1/28 (4%)    0/27 (0%)  |  0/25 (0%)    1/32 (3%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   671          728 (T)      728 (T)      640       |   681          610          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.573N     P=0.542N     P=0.513N     P=0.491N   |  P=0.345N     P=0.564      P=0.519N     P=0.477N   |
|INCIDENTAL TUMOR       |  P=0.558N     P=0.635N     P=0.601N     P=0.509N   |  P=0.341N     P=0.491      P=0.550N     P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.586N     P=0.513N     P=0.509N     P=0.508N   |  P=0.352N     P=0.469      P=0.505N     P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.596N                                          |  P=0.352N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   4
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    6/50 (12%)   5/50 (10%)   4/50 (8%)  |  3/50 (6%)    7/50 (14%)   3/50 (6%)    3/50 (6%)  |
|ADJUSTED (b)           |  12.6%        20.4%        16.3%        11.8%      |  10.8%        20.5%        10.9%         8.9%      |
|TERMINAL (d)           |  2/27 (7%)    5/28 (18%)   4/28 (14%)   2/27 (7%)  |  2/25 (8%)    6/32 (19%)   2/25 (8%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |   671          661          583          567       |   681          610          672          642       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.440N     P=0.353      P=0.500      P=0.638N   |  P=0.319N     P=0.266      P=0.643      P=0.595N   |
|INCIDENTAL TUMOR       |  P=0.445N     P=0.275      P=0.467      P=0.620    |  P=0.314N     P=0.232      P=0.624      P=0.617N   |
|LOGISTIC REGRESSION    |  P=0.413N     P=0.328      P=0.480      P=0.643N   |  P=0.381N     P=0.195      P=0.632      P=0.661    |
|COCHRAN-ARMITAGE       |  P=0.443N                                          |  P=0.373N                                          |
|FISHER EXACT           |               P=0.370      P=0.500      P=0.643N   |               P=0.159      P=0.661N     P=0.661N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/50 (8%)    4/50 (8%)    4/50 (8%)  |  0/49 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.5%        11.6%        11.5%        11.7%      |   0.0%         2.7%         3.0%         3.2%      |
|TERMINAL (d)           |  1/27 (4%)    1/28 (4%)    2/28 (7%)    2/27 (7%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   503          615          571          532       |   ---          701          667          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.598N     P=0.609      P=0.630      P=0.629N   |  P=0.642      P=0.549      P=0.467      P=0.543    |
|INCIDENTAL TUMOR       |  P=0.599N     P=0.589      P=0.616      P=0.586N   |  P=0.497      P=0.446      P=0.461      P=0.543    |
|LOGISTIC REGRESSION    |  P=0.595      P=0.624N     P=0.625N     P=0.630    |  P=0.621      P=0.510      P=0.505      P=0.543    |
|COCHRAN-ARMITAGE       |  P=0.616                                           |  P=0.624                                           |
|FISHER EXACT           |               P=0.643N     P=0.643N     P=0.643N   |               P=0.505      P=0.505      P=0.505    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   5
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.8%         3.4%         3.6%        10.6%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/27 (4%)    0/28 (0%)    1/28 (4%)    2/27 (7%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   566          720          728 (T)      723       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.257      P=0.503N     P=0.499N     P=0.503    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.280      P=0.541N     P=0.468N     P=0.485    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.272      P=0.499N     P=0.501N     P=0.505    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.253                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/50 (28%)  14/50 (28%)  16/50 (32%)  19/50 (38%) | 24/49 (49%)  25/50 (50%)  22/50 (44%)  22/50 (44%) |
|ADJUSTED (b)           |  43.3%        45.5%        48.3%        55.6%      |  73.8%        65.1%        63.0%        59.2%      |
|TERMINAL (d)           | 10/27 (37%)  12/28 (43%)  12/28 (43%)  13/27 (48%) | 17/25 (68%)  19/32 (59%)  13/25 (52%)  16/31 (52%) |
|FIRST INCIDENCE (DAYS) |   503          540          556          547       |   597          553          506          575       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.157      P=0.579N     P=0.430      P=0.208    |  P=0.227N     P=0.249N     P=0.476N     P=0.168N   |
|INCIDENTAL TUMOR       |  P=0.137      P=0.545N     P=0.424      P=0.187    |  P=0.423N     P=0.409N     P=0.443N     P=0.420N   |
|LOGISTIC REGRESSION    |  P=0.203      P=0.521      P=0.374      P=0.205    |  P=0.429N     P=0.456N     P=0.492N     P=0.394N   |
|COCHRAN-ARMITAGE       |  P=0.163                                           |  P=0.382N                                          |
|FISHER EXACT           |               P=0.588N     P=0.414      P=0.198    |               P=0.540      P=0.384N     P=0.384N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   6
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/50 (36%)  23/50 (46%)  14/50 (28%)  19/50 (38%) | 16/49 (33%)  12/50 (24%)  13/50 (26%)  18/50 (36%) |
|ADJUSTED (b)           |  45.4%        57.3%        40.8%        47.2%      |  42.9%        34.8%        43.8%        47.5%      |
|TERMINAL (d)           |  7/27 (26%)  12/28 (43%)   9/28 (32%)   8/27 (30%) |  7/25 (28%)  10/32 (31%)   9/25 (36%)  12/31 (39%) |
|FIRST INCIDENCE (DAYS) |   586          405          585          524       |   533          645          581          563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.545      P=0.200      P=0.308N     P=0.519    |  P=0.262      P=0.121N     P=0.384N     P=0.564    |
|INCIDENTAL TUMOR       |  P=0.532N     P=0.135      P=0.331N     P=0.520    |  P=0.186      P=0.208N     P=0.362N     P=0.475    |
|LOGISTIC REGRESSION    |  P=0.510      P=0.218      P=0.453N     P=0.469    |  P=0.152      P=0.212N     P=0.360N     P=0.431    |
|COCHRAN-ARMITAGE       |  P=0.513                                           |  P=0.171                                           |
|FISHER EXACT           |               P=0.208      P=0.260N     P=0.500    |               P=0.232N     P=0.306N     P=0.445    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/50 (40%)  24/50 (48%)  15/50 (30%)  21/50 (42%) | 16/49 (33%)  12/50 (24%)  13/50 (26%)  18/50 (36%) |
|ADJUSTED (b)           |  49.2%        58.7%        43.9%        51.7%      |  42.9%        34.8%        43.8%        47.5%      |
|TERMINAL (d)           |  8/27 (30%)  12/28 (43%)  10/28 (36%)   9/27 (33%) |  7/25 (28%)  10/32 (31%)   9/25 (36%)  12/31 (39%) |
|FIRST INCIDENCE (DAYS) |   566          405          585          524       |   533          645          581          563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490      P=0.257      P=0.251N     P=0.519    |  P=0.262      P=0.121N     P=0.384N     P=0.564    |
|INCIDENTAL TUMOR       |  P=0.546      P=0.176      P=0.252N     P=0.513    |  P=0.186      P=0.208N     P=0.362N     P=0.475    |
|LOGISTIC REGRESSION    |  P=0.451      P=0.284      P=0.329N     P=0.486    |  P=0.152      P=0.212N     P=0.360N     P=0.431    |
|COCHRAN-ARMITAGE       |  P=0.448                                           |  P=0.171                                           |
|FISHER EXACT           |               P=0.273      P=0.201N     P=0.500    |               P=0.232N     P=0.306N     P=0.445    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   7
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 28/50 (56%)  30/50 (60%)  26/50 (52%)  33/50 (66%) | 33/49 (67%)  31/50 (62%)  29/50 (58%)  34/50 (68%) |
|ADJUSTED (b)           |  67.1%        73.9%        70.9%        79.4%      |  86.1%        77.1%        75.7%        82.8%      |
|TERMINAL (d)           | 14/27 (52%)  18/28 (64%)  18/28 (64%)  19/27 (70%) | 20/25 (80%)  23/32 (72%)  16/25 (64%)  24/31 (77%) |
|FIRST INCIDENCE (DAYS) |   503          405          556          524       |   533          553          506          563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.212      P=0.386      P=0.447N     P=0.282    |  P=0.542      P=0.082N     P=0.376N     P=0.293N   |
|INCIDENTAL TUMOR       |  P=0.168      P=0.357      P=0.463N     P=0.216    |  P=0.204      P=0.212N     P=0.344N     P=0.459    |
|LOGISTIC REGRESSION    |  P=0.166      P=0.404      P=0.469N     P=0.209    |  P=0.213      P=0.221N     P=0.328N     P=0.478    |
|COCHRAN-ARMITAGE       |  P=0.144                                           |  P=0.300                                           |
|FISHER EXACT           |               P=0.420      P=0.421N     P=0.206    |               P=0.365N     P=0.226N     P=0.558    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  31/50 (62%)  26/50 (52%)  34/50 (68%) | 33/49 (67%)  31/50 (62%)  29/50 (58%)  34/50 (68%) |
|ADJUSTED (b)           |  70.3%        74.8%        70.9%        80.1%      |  86.1%        77.1%        75.7%        82.8%      |
|TERMINAL (d)           | 15/27 (56%)  18/28 (64%)  18/28 (64%)  19/27 (70%) | 20/25 (80%)  23/32 (72%)  16/25 (64%)  24/31 (77%) |
|FIRST INCIDENCE (DAYS) |   503          405          556          524       |   533          553          506          563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.220      P=0.448      P=0.322N     P=0.341    |  P=0.542      P=0.082N     P=0.376N     P=0.293N   |
|INCIDENTAL TUMOR       |  P=0.176      P=0.421      P=0.299N     P=0.270    |  P=0.204      P=0.212N     P=0.344N     P=0.459    |
|LOGISTIC REGRESSION    |  P=0.167      P=0.484      P=0.311N     P=0.269    |  P=0.213      P=0.221N     P=0.328N     P=0.478    |
|COCHRAN-ARMITAGE       |  P=0.144                                           |  P=0.300                                           |
|FISHER EXACT           |               P=0.500      P=0.273N     P=0.266    |               P=0.365N     P=0.226N     P=0.558    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   8
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.3%         0.0%         2.0%         6.1%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    1/27 (4%)  |  1/25 (4%)    0/32 (0%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   700          ---          435          609       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.288      P=0.507N     P=0.757      P=0.507    |  P=0.679N     P=0.451N     P=0.500N     P=0.457N   |
|INCIDENTAL TUMOR       |  P=0.287      P=0.621N     P=0.711      P=0.481    |  P=0.679N     P=0.451N     P=0.500N     P=0.457N   |
|LOGISTIC REGRESSION    |  P=0.231      P=0.510N     P=0.713N     P=0.499    |  P=0.679N     P=0.451N     P=0.500N     P=0.457N   |
|COCHRAN-ARMITAGE       |  P=0.274                                           |  P=0.703N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500    |               P=0.495N     P=0.495N     P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)  11/50 (22%)   9/50 (18%)   6/50 (12%) |  0/50 (0%)    5/50 (10%)   4/50 (8%)    3/50 (6%)  |
|ADJUSTED (b)           |  30.1%        31.6%        29.6%        20.5%      |   0.0%        14.4%        14.0%         7.8%      |
|TERMINAL (d)           |  7/27 (26%)   6/28 (21%)   7/28 (25%)   5/27 (19%) |  0/25 (0%)    3/32 (9%)    3/25 (12%)   1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   603          540          656          591       |   ---          698          581          601       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.166N     P=0.391      P=0.590N     P=0.287N   |  P=0.593N     P=0.061      P=0.062      P=0.128    |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.392      P=0.573      P=0.305N   |  P=0.565N     P=0.035 *    P=0.081      P=0.241    |
|LOGISTIC REGRESSION    |  P=0.135N     P=0.364      P=0.577      P=0.270N   |  P=0.619      P=0.047 *    P=0.057      P=0.127    |
|COCHRAN-ARMITAGE       |  P=0.164N                                          |  P=0.624                                           |
|FISHER EXACT           |               P=0.402      P=0.602N     P=0.288N   |               P=0.028 *    P=0.059      P=0.121    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE   9
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   4/50 (8%)    3/50 (6%)    3/50 (6%)  |  2/50 (4%)    4/50 (8%)    0/50 (0%)    7/50 (14%) |
|ADJUSTED (b)           |  15.4%        12.5%        10.0%         9.5%      |   7.3%        10.3%         0.0%        19.2%      |
|TERMINAL (d)           |  3/27 (11%)   2/28 (7%)    2/28 (7%)    2/27 (7%)  |  1/25 (4%)    2/32 (6%)    0/25 (0%)    3/31 (10%) |
|FIRST INCIDENCE (DAYS) |   469          622          689          567       |   708          483          ---          612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.423N     P=0.517N     P=0.348N     P=0.358N   |  P=0.029 *    P=0.437      P=0.248N     P=0.133    |
|INCIDENTAL TUMOR       |  P=0.409N     P=0.520N     P=0.406N     P=0.350N   |  P=0.009 **   P=0.294      P=0.267N     P=0.027 *  |
|LOGISTIC REGRESSION    |  P=0.420N     P=0.501N     P=0.366N     P=0.363N   |  P=0.016 *    P=0.302      P=0.253N     P=0.078    |
|COCHRAN-ARMITAGE       |  P=0.430N                                          |  P=0.017 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.357N     P=0.357N   |               P=0.339      P=0.247N     P=0.080    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  12/50 (24%)  11/50 (22%)   9/50 (18%) |  2/50 (4%)    9/50 (18%)   4/50 (8%)    9/50 (18%) |
|ADJUSTED (b)           |  40.1%        34.7%        35.0%        29.3%      |   7.3%        23.8%        14.0%        23.9%      |
|TERMINAL (d)           |  9/27 (33%)   7/28 (25%)   8/28 (29%)   7/27 (26%) |  1/25 (4%)    5/32 (16%)   3/25 (12%)   4/31 (13%) |
|FIRST INCIDENCE (DAYS) |   469          540          656          567       |   708          483          581          601       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245N     P=0.516N     P=0.393N     P=0.237N   |  P=0.159      P=0.069      P=0.330      P=0.054    |
|INCIDENTAL TUMOR       |  P=0.224N     P=0.508N     P=0.472N     P=0.244N   |  P=0.096      P=0.023 *    P=0.360      P=0.012 *  |
|LOGISTIC REGRESSION    |  P=0.206N     P=0.532N     P=0.445N     P=0.226N   |  P=0.100      P=0.028 *    P=0.311      P=0.026 *  |
|COCHRAN-ARMITAGE       |  P=0.243N                                          |  P=0.105                                           |
|FISHER EXACT           |               P=0.500N     P=0.408N     P=0.235N   |               P=0.026 *    P=0.339      P=0.026 *  |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  10
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/46 (9%)    2/48 (4%)    0/49 (0%)    1/48 (2%)  |
|ADJUSTED (b)           |                                                    |  16.1%         4.8%         0.0%         3.4%      |
|TERMINAL (d)           |                                                    |  3/22 (14%)   0/32 (0%)    0/25 (0%)    1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   675          685          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.361N     P=0.213N     P=0.055N     P=0.117N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.497N     P=0.360N     P=0.061N     P=0.165N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.397N     P=0.290N     P=0.060N     P=0.153N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.387N                                          |
|FISHER EXACT           |                                                    |               P=0.318N     P=0.051N     P=0.168N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/45 (0%)    0/47 (0%)    0/47 (0%)    0/41 (0%)  | 11/46 (24%)   8/47 (17%)   7/44 (16%)   5/43 (12%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  38.9%        23.9%        31.8%        16.7%      |
|TERMINAL (d)           |  0/25 (0%)    0/28 (0%)    0/27 (0%)    0/20 (0%)  |  9/25 (36%)   5/29 (17%)   7/22 (32%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   638          687          729 (T)      563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.118N     P=0.193N     P=0.300N     P=0.069N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.157N     P=0.239N     P=0.270N     P=0.053N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.207N     P=0.226N     P=0.338N     P=0.131N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.183N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.286N     P=0.247N     P=0.108N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  11
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.9%         0.0%      |   5.1%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    0/27 (0%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          656          ---       |   655          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.705N       (e)        P=0.483        (e)      |  P=0.490N     P=0.218N     P=0.271N     P=0.248N   |
|INCIDENTAL TUMOR       |  P=0.645N       (e)        P=0.410        (e)      |  P=0.701N     P=0.311N     P=0.293N     P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.733N       (e)        P=0.506        (e)      |  P=0.480N     P=0.261N     P=0.233N     P=0.232N   |
|COCHRAN-ARMITAGE       |  P=0.725N                                          |  P=0.482N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.6%         0.0%      |   6.1%         0.0%         0.0%         6.3%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    1/28 (4%)    0/27 (0%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          728 (T)      ---       |   675          ---          ---          720       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.729N       (e)        P=0.507        (e)      |  P=0.320      P=0.198N     P=0.265N     P=0.635N   |
|INCIDENTAL TUMOR       |  P=0.729N       (e)        P=0.507        (e)      |  P=0.111      P=0.311N     P=0.293N     P=0.411    |
|LOGISTIC REGRESSION    |  P=0.729N       (e)        P=0.507        (e)      |  P=0.279      P=0.241N     P=0.245N     P=0.693    |
|COCHRAN-ARMITAGE       |  P=0.725N                                          |  P=0.284                                           |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.247N     P=0.247N     P=0.691N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  12
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   6.1%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    0/27 (0%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   675          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.659      P=0.198N     P=0.265N     P=0.448N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.512      P=0.311N     P=0.293N     P=0.717N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.634      P=0.241N     P=0.245N     P=0.504N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.637                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.247N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.6%         0.0%      |   6.1%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    1/28 (4%)    0/27 (0%)  |  0/25 (0%)    0/32 (0%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          728 (T)      ---       |   675          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.729N       (e)        P=0.507        (e)      |  P=0.659      P=0.198N     P=0.265N     P=0.448N   |
|INCIDENTAL TUMOR       |  P=0.729N       (e)        P=0.507        (e)      |  P=0.512      P=0.311N     P=0.293N     P=0.717N   |
|LOGISTIC REGRESSION    |  P=0.729N       (e)        P=0.507        (e)      |  P=0.634      P=0.241N     P=0.245N     P=0.504N   |
|COCHRAN-ARMITAGE       |  P=0.725N                                          |  P=0.637                                           |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.247N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  13
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         2.7%         0.0%         0.0%      |   6.5%         6.3%         0.0%         5.6%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    0/27 (0%)  |  1/25 (4%)    2/32 (6%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          615          ---          ---       |   671          729 (T)      ---          612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.699N     P=0.480        (e)          (e)      |  P=0.539      P=0.619N     P=0.261N     P=0.665N   |
|INCIDENTAL TUMOR       |  P=0.780N     P=0.540        (e)          (e)      |  P=0.543      P=0.657N     P=0.267N     P=0.684N   |
|LOGISTIC REGRESSION    |  P=0.734N     P=0.522        (e)          (e)      |  P=0.504      P=0.658N     P=0.249N     P=0.693    |
|COCHRAN-ARMITAGE       |  P=0.706N                                          |  P=0.510                                           |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.691N     P=0.247N     P=0.691N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    5/49 (10%)   2/49 (4%)    0/50 (0%)  |  1/47 (2%)    1/50 (2%)    0/50 (0%)    2/49 (4%)  |
|ADJUSTED (b)           |   0.0%        15.5%         6.0%         0.0%      |   4.0%         2.7%         0.0%         5.6%      |
|TERMINAL (d)           |  0/27 (0%)    3/28 (11%)   1/28 (4%)    0/27 (0%)  |  1/25 (4%)    0/32 (0%)    0/25 (0%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          615          587          ---       |   729 (T)      701          ---          612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.133N     P=0.033 *    P=0.233        (e)      |  P=0.314      P=0.705N     P=0.500N     P=0.542    |
|INCIDENTAL TUMOR       |  P=0.162N     P=0.039 *    P=0.266        (e)      |  P=0.304      P=0.750N     P=0.500N     P=0.640    |
|LOGISTIC REGRESSION    |  P=0.127N     P=0.031 *    P=0.242        (e)      |  P=0.282      P=0.727N     P=0.500N     P=0.513    |
|COCHRAN-ARMITAGE       |  P=0.128N                                          |  P=0.283                                           |
|FISHER EXACT           |               P=0.028 *    P=0.247        (e)      |               P=0.737N     P=0.485N     P=0.516    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  14
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         3.0%         0.0%         0.0%      |   0.0%         6.3%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    0/27 (0%)  |  0/25 (0%)    2/32 (6%)    0/25 (0%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          654          ---          ---       |   ---          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.683N     P=0.477        (e)          (e)      |  P=0.455N     P=0.294        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.626N     P=0.379        (e)          (e)      |  P=0.455N     P=0.294        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.715N     P=0.508        (e)          (e)      |  P=0.455N     P=0.294        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.706N                                          |  P=0.485N                                          |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/49 (0%)    1/50 (2%)    0/50 (0%)  |  5/50 (10%)   3/50 (6%)    2/49 (4%)    4/50 (8%)  |
|ADJUSTED (b)           |   3.4%         0.0%         3.6%         0.0%      |  18.0%         9.4%         8.0%        12.9%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    1/28 (4%)    0/27 (0%)  |  4/25 (16%)   3/32 (9%)    2/25 (8%)    4/31 (13%) |
|FIRST INCIDENCE (DAYS) |   707          ---          728 (T)      ---       |   654          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.494N     P=0.500N     P=0.756N     P=0.487N   |  P=0.580      P=0.239N     P=0.220N     P=0.387N   |
|INCIDENTAL TUMOR       |  P=0.451N     P=0.621N     P=0.716      P=0.483N   |  P=0.553      P=0.262N     P=0.233N     P=0.449N   |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.513N     P=0.759      P=0.496N   |  P=0.542      P=0.278N     P=0.247N     P=0.463N   |
|COCHRAN-ARMITAGE       |  P=0.497N                                          |  P=0.511                                           |
|FISHER EXACT           |               P=0.505N     P=0.753N     P=0.500N   |               P=0.357N     P=0.226N     P=0.500N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  15
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |                                                    |   2.5%         0.0%         2.4%         6.5%      |
|TERMINAL (d)           |                                                    |  0/25 (0%)    0/32 (0%)    0/25 (0%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   655          ---          624          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.282      P=0.486N     P=0.741      P=0.541    |
|INCIDENTAL TUMOR       |                                                    |  P=0.290      P=0.565N     P=0.731N     P=0.431    |
|LOGISTIC REGRESSION    |                                                    |  P=0.273      P=0.535N     P=0.752N     P=0.497    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.274                                           |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.753N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |                                                    |   5.5%         0.0%         2.4%         6.5%      |
|TERMINAL (d)           |                                                    |  0/25 (0%)    0/32 (0%)    0/25 (0%)    2/31 (6%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   655          ---          624          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.405      P=0.203N     P=0.532N     P=0.650N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.352      P=0.311N     P=0.495N     P=0.546    |
|LOGISTIC REGRESSION    |                                                    |  P=0.393      P=0.255N     P=0.489N     P=0.691    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.395                                           |
|FISHER EXACT           |                                                    |               P=0.247N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  16
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         3.6%         3.6%         5.8%      |   4.0%         0.0%         4.0%         3.2%      |
|TERMINAL (d)           |  0/27 (0%)    1/28 (4%)    1/28 (4%)    1/27 (4%)  |  1/25 (4%)    0/32 (0%)    1/25 (4%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      728 (T)      566       |   729 (T)      ---          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.269      P=0.507      P=0.507      P=0.235    |  P=0.655      P=0.451N     P=0.763      P=0.714N   |
|INCIDENTAL TUMOR       |  P=0.237      P=0.507      P=0.507      P=0.212    |  P=0.655      P=0.451N     P=0.763      P=0.714N   |
|LOGISTIC REGRESSION    |  P=0.281      P=0.507      P=0.507      P=0.226    |  P=0.655      P=0.451N     P=0.763      P=0.714N   |
|COCHRAN-ARMITAGE       |  P=0.273                                           |  P=0.624                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.247    |               P=0.500N     P=0.753N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    6/50 (12%)   4/50 (8%)    4/50 (8%)  |  2/50 (4%)    3/50 (6%)    1/50 (2%)    5/50 (10%) |
|ADJUSTED (b)           |  11.5%        18.2%        11.5%        11.7%      |   6.5%         8.8%         3.0%        15.0%      |
|TERMINAL (d)           |  1/27 (4%)    3/28 (11%)   2/28 (7%)    2/27 (7%)  |  1/25 (4%)    2/32 (6%)    0/25 (0%)    4/31 (13%) |
|FIRST INCIDENCE (DAYS) |   503          615          571          532       |   671          701          667          612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.483N     P=0.352      P=0.630      P=0.629N   |  P=0.139      P=0.595      P=0.542N     P=0.276    |
|INCIDENTAL TUMOR       |  P=0.480N     P=0.325      P=0.616      P=0.586N   |  P=0.088      P=0.508      P=0.558N     P=0.263    |
|LOGISTIC REGRESSION    |  P=0.508N     P=0.373      P=0.625N     P=0.630    |  P=0.102      P=0.540      P=0.514N     P=0.212    |
|COCHRAN-ARMITAGE       |  P=0.495N                                          |  P=0.107                                           |
|FISHER EXACT           |               P=0.370      P=0.643N     P=0.643N   |               P=0.500      P=0.500N     P=0.218    |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  17
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    7/50 (14%)   5/50 (10%)   5/50 (10%) |  3/50 (6%)    3/50 (6%)    2/50 (4%)    6/50 (12%) |
|ADJUSTED (b)           |  11.5%        21.5%        14.9%        13.6%      |  10.4%         8.8%         6.9%        18.2%      |
|TERMINAL (d)           |  1/27 (4%)    4/28 (14%)   3/28 (11%)   2/27 (7%)  |  2/25 (8%)    2/32 (6%)    1/25 (4%)    5/31 (16%) |
|FIRST INCIDENCE (DAYS) |   503          615          571          532       |   671          701          667          612       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.538N     P=0.253      P=0.494      P=0.507    |  P=0.139      P=0.558N     P=0.533N     P=0.323    |
|INCIDENTAL TUMOR       |  P=0.552N     P=0.228      P=0.476      P=0.540    |  P=0.094      P=0.637N     P=0.546N     P=0.312    |
|LOGISTIC REGRESSION    |  P=0.563N     P=0.258      P=0.512      P=0.475    |  P=0.096      P=0.615N     P=0.528N     P=0.240    |
|COCHRAN-ARMITAGE       |  P=0.550N                                          |  P=0.101                                           |
|FISHER EXACT           |               P=0.262      P=0.500      P=0.500    |               P=0.661N     P=0.500N     P=0.243    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.2%         6.5%      |   4.7%         2.1%         6.1%         2.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/28 (0%)    0/28 (0%)    1/27 (4%)  |  0/25 (0%)    0/32 (0%)    1/25 (4%)    0/31 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          563          685       |   649          577          564          426       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.157        (e)        P=0.491      P=0.250    |  P=0.516N     P=0.484N     P=0.672      P=0.527N   |
|INCIDENTAL TUMOR       |  P=0.154        (e)        P=0.540      P=0.249    |  P=0.428N     P=0.575N     P=0.691N     P=0.697N   |
|LOGISTIC REGRESSION    |  P=0.141        (e)        P=0.560      P=0.242    |  P=0.491N     P=0.608N     P=0.682N     P=0.425N   |
|COCHRAN-ARMITAGE       |  P=0.149                                           |  P=0.499N                                          |
|FISHER EXACT           |                 (e)        P=0.500      P=0.247    |               P=0.500N     P=0.691N     P=0.500N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  18
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    5/50 (10%)   2/50 (4%)  | 11/50 (22%)  13/50 (26%)  11/50 (22%)   6/50 (12%) |
|ADJUSTED (b)           |  11.8%         7.1%        16.3%         7.1%      |  32.8%        33.3%        33.9%        15.5%      |
|TERMINAL (d)           |  2/27 (7%)    2/28 (7%)    3/28 (11%)   1/27 (4%)  |  5/25 (20%)   8/32 (25%)   6/25 (24%)   3/31 (10%) |
|FIRST INCIDENCE (DAYS) |   603          728 (T)      656          725       |   597          623          567          449       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.313N     P=0.351N     P=0.494      P=0.343N   |  P=0.056N     P=0.552N     P=0.547      P=0.108N   |
|INCIDENTAL TUMOR       |  P=0.297N     P=0.296N     P=0.479      P=0.370N   |  P=0.055N     P=0.435      P=0.576N     P=0.101N   |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.353N     P=0.482      P=0.334N   |  P=0.065N     P=0.428      P=0.555      P=0.138N   |
|COCHRAN-ARMITAGE       |  P=0.315N                                          |  P=0.064N                                          |
|FISHER EXACT           |               P=0.339N     P=0.500      P=0.339N   |               P=0.408      P=0.595N     P=0.143N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/50 (44%)  26/50 (52%)  28/50 (56%)  29/50 (58%) | 34/50 (68%)  32/50 (64%)  33/50 (66%)  31/50 (62%) |
|ADJUSTED (b)           |  63.7%        73.8%        76.8%        79.5%      |  94.1%        77.7%        88.5%        73.7%      |
|TERMINAL (d)           | 15/27 (56%)  19/28 (68%)  20/28 (71%)  20/27 (74%) | 23/25 (92%)  23/32 (72%)  21/25 (84%)  20/31 (65%) |
|FIRST INCIDENCE (DAYS) |   503          540          556          547       |   597          553          293          563       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.233      P=0.273      P=0.184      P=0.136    |  P=0.183N     P=0.064N     P=0.572N     P=0.111N   |
|INCIDENTAL TUMOR       |  P=0.211      P=0.181      P=0.138      P=0.098    |  P=0.370N     P=0.184N     P=0.507N     P=0.333N   |
|LOGISTIC REGRESSION    |  P=0.300      P=0.166      P=0.110      P=0.119    |  P=0.437N     P=0.211N     P=0.530      P=0.394N   |
|COCHRAN-ARMITAGE       |  P=0.223                                           |  P=0.365N                                          |
|FISHER EXACT           |               P=0.274      P=0.159      P=0.115    |               P=0.417N     P=0.500N     P=0.338N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  19
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      500 U        5000 U       5000 U A  |   VEHICLE      500 U        5000 U       5000 U A  |
|                       |   CONTROL      A/D          A/D                    |   CONTROL      A/D          A/D                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/50 (64%)  30/50 (60%)  25/50 (50%)  30/50 (60%) | 35/50 (70%)  33/50 (66%)  28/50 (56%)  30/50 (60%) |
|ADJUSTED (b)           |  69.1%        69.2%        62.7%        65.8%      |  73.6%        71.2%        72.1%        66.0%      |
|TERMINAL (d)           | 13/27 (48%)  15/28 (54%)  14/28 (50%)  12/27 (44%) | 13/25 (52%)  19/32 (59%)  15/25 (60%)  16/31 (52%) |
|FIRST INCIDENCE (DAYS) |   469          405          435          524       |   409          483          506          426       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.528      P=0.514N     P=0.199N     P=0.420N   |  P=0.275N     P=0.153N     P=0.260N     P=0.155N   |
|INCIDENTAL TUMOR       |  P=0.534N     P=0.555N     P=0.168N     P=0.384N   |  P=0.320N     P=0.524N     P=0.158N     P=0.279N   |
|LOGISTIC REGRESSION    |  P=0.461      P=0.391N     P=0.114N     P=0.390N   |  P=0.396N     P=0.546N     P=0.133N     P=0.299N   |
|COCHRAN-ARMITAGE       |  P=0.480                                           |  P=0.353N                                          |
|FISHER EXACT           |               P=0.418N     P=0.113N     P=0.418N   |               P=0.415N     P=0.107N     P=0.201N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 42/50 (84%)  40/50 (80%)  41/50 (82%)  47/50 (94%) | 48/50 (96%)  48/50 (96%)  44/50 (88%)  44/50 (88%) |
|ADJUSTED (b)           |  89.3%        90.7%        93.0%        95.9%      |  98.0%        96.0%        97.7%        93.6%      |
|TERMINAL (d)           | 22/27 (81%)  24/28 (86%)  25/28 (89%)  25/27 (93%) | 24/25 (96%)  30/32 (94%)  24/25 (96%)  28/31 (90%) |
|FIRST INCIDENCE (DAYS) |   469          405          435          524       |   409          483          293          426       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.183      P=0.497N     P=0.509N     P=0.304    |  P=0.152N     P=0.101N     P=0.433N     P=0.086N   |
|INCIDENTAL TUMOR       |  P=0.050 *    P=0.539N     P=0.608      P=0.107    |  P=0.133N     P=0.586N     P=0.211N     P=0.200N   |
|LOGISTIC REGRESSION    |  P=0.045 *    P=0.456N     P=0.588N     P=0.103    |  P=0.196N     P=0.610N     P=0.296N     P=0.185N   |
|COCHRAN-ARMITAGE       |  P=0.034 *                                         |  P=0.172N                                          |
|FISHER EXACT           |               P=0.398N     P=0.500N     P=0.100    |               P=0.691N     P=0.134N     P=0.134N   |
|=================================================================================================================================|
         DATE: 12/30/96                     EXPERIMENT: 89006 TEST: 08                                                 PAGE  20
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9  INTERFERON A/INTERFERON AD

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.