National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5845

TDMS Study 89006-08 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                            INTERFERON A/INTERFERON AD                              DATE: 12/30/96       
EXPERIMENT: 89006 TEST: 08                                                                                     TIME: 17:14:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-85225                              ROUTE: SUBCUTANEOUS                                            NTP C#: C89001       
PATHOLOGIST: MISSING                                                                                           CAS: 76543-88-9      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Southern Research Inst                            INTERFERON A/INTERFERON AD                              DATE: 12/30/96      
EXPERIMENT: 89006 TEST: 08                                                                                     TIME: 17:14:54      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-85225                              ROUTE: SUBCUTANEOUS                                            NTP C#: C89001      
PATHOLOGIST: MISSING                                                                                           CAS: 76543-88-9     
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   469   503   566   582   586   596   603   605   626                 |
 |      626   626   653   664   671   673   673   673   682   689                 |
 |      700   707   717                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 U   A/D                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   489   507   538   540   547   552   558   564   573                 |
 |      580   580   590   615   622   637   653   654   661   664                 |
 |      667   720                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 U  A/D                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 1    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      435   486   524   556   563   571   572   583   585   587                 |
 |      588   615   619   633   649   656   689   689   694   699                 |
 |      721                                                                       |
 |  CENSORED DEATHS                                                               |
 |      113                                                                       |
 |                                                                                |
 ==================================================================================
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5000 U A                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      524   532   533   544   547   566   567   580   591   609                 |
 |      640   654   658   658   675   678   685   695   700   707                 |
 |      722   723   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  96.0  94.0  82.0  72.0  54.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |500 U   A/D|   100.0 100.0 100.0 100.0  98.0  98.0  90.0  74.0  60.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 U  A/D|   100.0 100.0 100.0 100.0 100.0  98.0  93.9  77.6  67.3  57.1      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 U A   |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  82.0  72.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      500 U   A/D  5000 U  A/D  5000 U A |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%        56.0%        57.1%        54.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000N     P=0.973      P=1.000N     P=1.000N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       621.5        587.1        605.4        631.0    |
 |NATURAL DEATHS (C)      |       (16.4)       (15.2)       (16.0)       (14.6)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       679.0        666.0        664.2        683.4    |
 |(STANDARD ERROR)        |       (10.6)       (12.0)       (15.6)       ( 9.6)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      365   409   533   567   597   601   638   649   651   654                 |
 |      655   671   671   673   673   675   678   681   685   689                 |
 |      699   708   708   721   727                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 U   A/D                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      483   553   577   610   623   645   654   658   685   685                 |
 |      686   687   698   701   704   715   720   722                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 U  A/D                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 1    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      22    293   506   564   567   581   583   604   624   632                 |
 |      652   652   654   659   659   660   667   672   678   683                 |
 |      685   691   715   727                                                     |
 |  CENSORED DEATHS                                                               |
 |      1                                                                         |
 |                                                                                |
 ==================================================================================
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5000 U A                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      149   426   449   483   563   563   567   575   601   612                 |
 |      615   636   642   682   702   707   708   708   720                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                            INTERFERON A/INTERFERON AD

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0  98.0  96.0  96.0  94.0  88.0  78.0  50.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |500 U   A/D|   100.0 100.0 100.0 100.0 100.0  98.0  98.0  94.0  84.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 U  A/D|    98.0  98.0  98.0  95.9  95.9  95.9  93.9  83.7  67.3  51.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 U A   |   100.0  98.0  98.0  98.0  98.0  92.0  92.0  82.0  74.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      500 U   A/D  5000 U  A/D  5000 U A |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.0%        64.0%        51.0%        62.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.631N     P=0.174N     P=1.000      P=0.417N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       639.1        655.9        601.3        584.6    |
 |NATURAL DEATHS (C)      |       (17.8)       (15.3)       (30.9)       (31.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       684.1        702.7        653.1        674.1    |
 |(STANDARD ERROR)        |       (10.9)       ( 7.4)       (21.8)       (15.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                     INTERFERON A/INTERFERON AD
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        500 U   A/D      = 2
                                                        5000 U  A/D      = 3
                                                        5000 U A         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                                               1    3             4
      |
      |                                                                 1    3    1  2     44
      |                                                                           1  2 12  344
   95 +
      |                                                                                12  3 24 31
      |                                                                                      224 1  1
      |                                                                                         33
   90 +                                                                                       22 33
      |
      |                                                                                             1  1
      |                                                                                        224343  11
P  85 +
E     |                                                                                         22 4  4
R     |                                                                                          22   4 1  1
C     |
E  80 +                                                                                           22    4    4
N     |
T     |                                                                                             3    3   4 4
      |                                                                                            2  2    1   1
S  75 +                                                                                                  33
U     |                                                                                               2  23 3  1 1
R     |                                                                                                  22    4 114
V     |                                                                                                     3 3
I  70 +                                                                                                   2 2 33  11
V     |
A     |                                                                                                     2  2   443
L     |                                                                                                             4 4
   65 +
      |                                                                                                        2 2 1133
      |                                                                                                             1144
      |
   60 +                                                                                                          22  114  4
      |                                                                                                               3  3
      |                                                                                                           2   11 23
      |                                                                                                                1 12
   55 +
      |                                                                                                                  11
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.
                                                     INTERFERON A/INTERFERON AD
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        500 U   A/D      = 2
                                                        5000 U  A/D      = 3
                                                        5000 U A         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1   3                   4                                 1                 2
      |
      |     3                   4                     3           1      1 4        2          2
      |                                               3                  1 4    4       3    1 2   2
   95 +
      |                                                                         4   4   3    1   1 2     2
      |                                                                             4            1     1 22
      |
   90 +                                                                                          3 3      2   2
      |
      |                                                                                            33  1     122
      |                                                                                          4 43   3    11
P  85 +
E     |                                                                                            4   43  3   2    2
R     |                                                                                                4 4    11
C     |                                                                                                    33
E  80 +                                                                                                     3  3
N     |
T     |                                                                                                  4  4  1  1 22
      |                                                                                                     44       22
S  75 +
U     |                                                                                                      4 3 3114 22
R     |                                                                                                             4  4
V     |
I  70 +                                                                                                                2 2
V     |
A     |                                                                                                          33    44
L     |                                                                                                            11    22
   65 +
      |                                                                                                           33    442 2
      |                                                                                                             11   4  4
      |                                                                                                            33
   60 +                                                                                                              11
      |
      |                                                                                                             331 1
      |
   55 +                                                                                                              3   3
      |                                                                                                                 11
      |                                                                                                                  11
      |                                                                                                                   3 3
   50 +                                                                                                                   1 1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.