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TDMS Study 89006-02 Pathology Tables

NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96
Route: GAVAGE                                                                                                     Time: 08:14:07

                                                           CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-871

       Lock Date:  11/01/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6            5            9                                     
    Moribund Sacrifice                                 7            8           11           12                                     
    Dosing Accident                                    3            2            2            4                                     
    Accidently Killed                                               2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           32           24                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    50           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (48)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Perforation                                      2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
   Intestine Large, Colon                             (50)         (48)         (50)         (49)                                   
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (49)         (50)         (48)                                   
      Edema                                            1 (2%)       2 (4%)                    1 (2%)                                
      Parasite Metazoan                                                          1 (2%)       2 (4%)                                
   Intestine Small, Duodenum                          (48)         (49)         (48)         (48)                                   
      Erosion                                          1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (49)         (49)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Intestine Small, Ileum                             (49)         (49)         (46)         (47)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                                           1 (2%)       3 (6%)                                
      Clear Cell Focus                                                                        2 (4%)                                
      Eosinophilic Focus                               5 (10%)      1 (2%)       5 (10%)      3 (6%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       3 (6%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic                            6 (12%)      6 (12%)      5 (10%)      7 (14%)                               
      Mixed Cell Focus                                 2 (4%)                    1 (2%)       1 (2%)                                
      Necrosis, Focal                                  4 (8%)                    6 (12%)      8 (16%)                               
      Pigmentation, Focal                                           1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                                                  1 (2%)       2 (4%)                                
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Centrilobular, Necrosis                                                                 1 (2%)                                
      Centrilobular, Necrosis, Focal                                1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Karyomegaly                                       1 (2%)       1 (2%)                                             
      Hepatocyte, Mixed Cell Focus                                               1 (2%)                                             
   Mesentery                                          (10)         (11)         (9)          (6)                                    
      Fat, Necrosis                                    8 (80%)      9 (82%)      7 (78%)      3 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Cyst                                             3 (6%)                                 1 (2%)                                
      Acinus, Atrophy, Diffuse                                                                3 (6%)                                
   Salivary Glands                                    (50)         (49)         (49)         (48)                                   
      Inflammation, Chronic                            2 (4%)       5 (10%)      2 (4%)       3 (6%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Edema                                                         1 (2%)                                                          
      Epithelium, Hyperplasia                          2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Edema                                                         2 (4%)                    1 (2%)                                
      Erosion                                                                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
      Hypertrophy                                                                             1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Heart                                              (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Mineralization                                                3 (6%)                                                          
      Thrombosis                                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                7 (14%)      5 (10%)      6 (12%)      5 (10%)                               
      Hyperplasia, Focal                               1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Hypertrophy, Focal                                                                      2 (4%)                                
      Capsule, Hyperplasia, Focal                      2 (4%)       1 (2%)                    2 (4%)                                
   Adrenal Medulla                                    (49)         (49)         (49)         (48)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
   Parathyroid Gland                                  (45)         (43)         (46)         (44)                                   
      Cyst                                                                       3 (7%)       1 (2%)                                
   Pituitary Gland                                    (50)         (47)         (48)         (47)                                   
      Pars Distalis, Angiectasis                                    3 (6%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                3 (6%)       9 (19%)      5 (10%)      4 (9%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic, Focal                     12 (24%)     15 (30%)     13 (26%)      9 (18%)                               
      Follicle, Cyst                                   8 (16%)      4 (8%)       7 (14%)      9 (18%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                    27 (54%)     16 (32%)     22 (44%)     13 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (49)         (49)                                   
      Angiectasis                                      5 (10%)     10 (20%)      7 (14%)      6 (12%)                               
      Cyst                                             9 (18%)      6 (12%)     13 (27%)      7 (14%)                               
      Hyperplasia, Tubular                                                                    1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Angiectasis                                      1 (2%)                    1 (2%)       2 (4%)                                
      Hydrometra                                      14 (28%)     17 (34%)     19 (38%)     25 (51%)                               
      Inflammation, Suppurative                        2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Endometrium, Hyperplasia, Cystic                35 (70%)     41 (82%)     36 (72%)     31 (63%)                               
   Vagina                                             (49)         (44)         (48)         (48)                                   
      Epithelium, Hyperplasia                                       4 (9%)       6 (13%)     11 (23%)                               
      Epithelium, Hyperplasia, Atypical                                          2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Hyperplasia                                     10 (20%)     14 (28%)     16 (32%)     14 (29%)                               
      Myelofibrosis                                    2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
   Lymph Node                                         (4)          (8)          (10)         (10)                                   
      Iliac, Hemorrhage                                                          1 (10%)                                            
      Iliac, Hyperplasia, Lymphoid                                               2 (20%)                                            
      Inguinal, Hyperplasia, Lymphoid                                            1 (10%)      1 (10%)                               
      Mediastinal, Hematopoietic Cell Proliferation                              1 (10%)                                            
      Mediastinal, Hyperplasia, Lymphoid               1 (25%)                   1 (10%)      1 (10%)                               
      Renal, Hemorrhage                                                          1 (10%)                                            
      Renal, Hyperplasia, Lymphoid                                               1 (10%)                                            
   Lymph Node, Mandibular                             (49)         (45)         (46)         (48)                                   
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)       5 (11%)      4 (9%)       2 (4%)                                
      Pigmentation                                     7 (14%)      8 (18%)     12 (26%)     14 (29%)                               
   Lymph Node, Mesenteric                             (50)         (47)         (49)         (49)                                   
      Hematopoietic Cell Proliferation                              3 (6%)       1 (2%)       3 (6%)                                
      Hemorrhage                                       5 (10%)      5 (11%)      2 (4%)       2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)       6 (13%)      8 (16%)      2 (4%)                                
   Spleen                                             (50)         (50)         (50)         (49)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                25 (50%)     28 (56%)     26 (52%)     30 (61%)                               
      Hyperplasia, Lymphoid                            6 (12%)     17 (34%)     10 (20%)      3 (6%)                                
      Pigmentation                                     1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
   Thymus                                             (47)         (46)         (46)         (45)                                   
      Atrophy                                          1 (2%)                    3 (7%)       2 (4%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (49)                                   
      Hyperplasia                                      5 (10%)                   7 (14%)      2 (4%)                                
   Skin                                               (49)         (50)         (50)         (49)                                   
      Ulcer                                                                      1 (2%)                                             
      Epidermis, Hyperplasia, Focal                                 1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Edema                       1 (2%)       3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage, Focal                                                  1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                       1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (49)                                   
      Hyperostosis                                    40 (82%)     39 (78%)     41 (82%)     34 (69%)                               
      Femur, Osteopetrosis                                          1 (2%)       3 (6%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (49)                                   
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Atrophy, Focal                                   4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Developmental Malformation                                                              1 (2%)                                
      Hydrocephalus                                                              1 (2%)       1 (2%)                                
      Necrosis                                         1 (2%)       1 (2%)                    1 (2%)                                
   Peripheral Nerve                                   (2)          (1)          (6)          (3)                                    
      Atrophy                                                       1 (100%)     1 (17%)      1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Hemorrhage                                       5 (10%)      2 (4%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                2 (4%)       2 (4%)                    1 (2%)                                
      Inflammation, Chronic                            3 (6%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Suppurative                        2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        1 (2%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Congestion                                                                              1 (2%)                                
      Metaplasia, Focal, Osseous                                    2 (4%)       2 (4%)       1 (2%)                                
      Nephropathy                                     36 (72%)     34 (68%)     30 (60%)     30 (61%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)                    1 (2%)       1 (2%)                                
      Renal Tubule, Dilatation                         1 (2%)                    1 (2%)       1 (2%)                                
      Renal Tubule, Hyaline Droplet                                 1 (2%)                                                          
      Renal Tubule, Necrosis                           1 (2%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Pigmentation                                    2 (4%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14            5            9                                     
    Natural Death                                      1            7            4            6                                     
    Dosing Accident                                                 2            2                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           38           35                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Perforation                                                   2 (4%)       1 (2%)                                             
   Gallbladder                                        (50)         (47)         (50)         (46)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Edema                                            2 (4%)                                                                       
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Edema                                            1 (2%)       2 (4%)       1 (2%)                                             
      Parasite Metazoan                                3 (6%)       7 (14%)      3 (6%)       5 (10%)                               
   Intestine Small, Ileum                             (50)         (48)         (49)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                 1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)       1 (2%)                                             
      Basophilic Focus                                 4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Clear Cell Focus                                 1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       6 (12%)      1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                           39 (78%)     38 (76%)     38 (76%)     44 (88%)                               
      Metaplasia, Osseous                              2 (4%)       1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)                    2 (4%)       1 (2%)                                
      Necrosis, Focal                                  1 (2%)       7 (14%)                   4 (8%)                                
      Pigmentation, Focal                              2 (4%)                    1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                        3 (6%)       2 (4%)       1 (2%)                                             
      Bile Duct, Hyperplasia                          26 (52%)     26 (52%)     26 (52%)     23 (46%)                               
      Hepatocyte, Karyomegaly                         33 (66%)     31 (62%)     35 (70%)     40 (80%)                               
   Mesentery                                          (1)          (2)          (1)                                                 
      Fat, Necrosis                                    1 (100%)                  1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                    2 (4%)                                             
      Acinus, Atrophy, Diffuse                         2 (4%)       1 (2%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)                    2 (4%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Edema                                                                                   2 (4%)                                
      Erosion                                                       1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Hypertrophy                                                   1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       2 (4%)       2 (4%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                                         5 (10%)      1 (2%)                                             
      Mineralization                                                2 (4%)                    1 (2%)                                
      Thrombosis                                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                7 (14%)      6 (12%)      1 (2%)       1 (2%)                                
      Cytoplasmic Alteration, Focal                    9 (18%)      7 (14%)     10 (20%)     12 (24%)                               
      Hyperplasia, Focal                               7 (14%)      3 (6%)       8 (16%)     16 (32%)                               
      Hypertrophy, Diffuse                                          1 (2%)                                                          
      Hypertrophy, Focal                              11 (22%)      5 (10%)     14 (28%)     13 (26%)                               
      Capsule, Hyperplasia, Focal                      4 (8%)       2 (4%)       3 (6%)       4 (8%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       4 (8%)       5 (10%)      7 (14%)                               
   Parathyroid Gland                                  (48)         (47)         (48)         (47)                                   
      Cyst                                                          1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (48)         (43)         (48)         (47)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)                                                          
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                                          1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic, Focal                     12 (24%)     14 (28%)     11 (22%)     14 (29%)                               
      Follicle, Cyst                                   3 (6%)       4 (8%)       7 (14%)      5 (10%)                               
      Follicular Cell, Hyperplasia                    12 (24%)     15 (30%)     19 (38%)     10 (20%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            2 (4%)                                             
   Preputial Gland                                    (48)         (48)         (50)         (50)                                   
      Cyst                                            10 (21%)      7 (15%)      4 (8%)       4 (8%)                                
      Inflammation, Chronic                            7 (15%)     13 (27%)      6 (12%)      4 (8%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
      Cyst                                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     14 (28%)     23 (46%)     16 (32%)     21 (42%)                               
   Lymph Node                                         (5)          (8)          (5)          (5)                                    
      Bronchial, Hyperplasia, Lymphoid                                           1 (20%)      1 (20%)                               
      Mediastinal, Hemorrhage                                       1 (13%)                                                         
      Mediastinal, Hyperplasia, Lymphoid               1 (20%)                   1 (20%)                                            
      Pancreatic, Hyperplasia, Lymphoid                                          1 (20%)                                            
      Renal, Hemorrhage                                             1 (13%)                                                         
   Lymph Node, Mandibular                             (46)         (47)         (49)         (46)                                   
      Hyperplasia, Lymphoid                            2 (4%)       4 (9%)       2 (4%)       2 (4%)                                
      Pigmentation                                     4 (9%)      10 (21%)     13 (27%)      8 (17%)                               
   Lymph Node, Mesenteric                             (50)         (48)         (50)         (47)                                   
      Hematopoietic Cell Proliferation                 7 (14%)      6 (13%)      1 (2%)       7 (15%)                               
      Hemorrhage                                      19 (38%)     15 (31%)     17 (34%)     18 (38%)                               
      Hyperplasia, Lymphoid                            6 (12%)      5 (10%)     12 (24%)      8 (17%)                               
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                20 (40%)     29 (59%)     17 (35%)     23 (46%)                               
      Hyperplasia, Lymphoid                            6 (12%)      4 (8%)       4 (8%)       1 (2%)                                
      Necrosis, Focal                                                                         1 (2%)                                
      Pigmentation                                     1 (2%)       1 (2%)                                                          
   Thymus                                             (45)         (40)         (42)         (43)                                   
      Atrophy                                          1 (2%)       3 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                                         2 (4%)                    2 (4%)                                
      Subcutaneous Tissue, Edema                       4 (8%)       4 (8%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                    42 (84%)     31 (62%)     39 (78%)     39 (78%)                               
      Femur, Osteopetrosis                                                                    1 (2%)                                
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                                1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)       1 (2%)       5 (10%)      1 (2%)                                
      Infiltration Cellular, Histiocyte                6 (12%)      6 (12%)      8 (16%)      4 (8%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    2 (4%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)       2 (4%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                       (1)                                    
      Atrophy                                          1 (100%)                               1 (100%)                              
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 89006-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 08:14:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                                       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Metaplasia, Focal, Osseous                       2 (4%)       1 (2%)                                                          
      Nephropathy                                     47 (94%)     46 (92%)     44 (88%)     49 (98%)                               
      Pelvis, Dilatation                                            1 (2%)       1 (2%)                                             
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)                                                                       
      Renal Tubule, Hyaline Droplet                                 1 (2%)                                                          
      Renal Tubule, Necrosis                                                                  1 (2%)                                
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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                             ----------              END OF REPORT             ----------                                           
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