National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5803

TDMS Study 89006-02 Pathology Tables

NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96
Route: GAVAGE                                                                                                     Time: 09:09:50

                                                           CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-871

       Lock Date:  11/01/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6            5            9                                     
    Moribund Sacrifice                                 7            8           11           12                                     
    Dosing Accident                                    3            2            2            4                                     
    Accidently Killed                                               2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           32           24                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (47)         (49)         (48)                                   
      Fibrosarcoma, Metastatic, Uterus                                           1 (2%)                                             
   Intestine Large, Colon                             (50)         (48)         (50)         (49)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (49)         (49)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Small, Ileum                             (49)         (49)         (46)         (47)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                            1 (2%)                                             
      Hemangiosarcoma                                                                         1 (2%)                                
      Hemangiosarcoma, Multiple                                                               1 (2%)                                
      Hepatocellular Carcinoma                        12 (24%)      2 (4%)       3 (6%)       6 (12%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Hepatocellular Adenoma                           8 (16%)     14 (28%)     11 (22%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                 3 (6%)       3 (6%)       3 (6%)       3 (6%)                                
      Histiocytic Sarcoma                              2 (4%)       3 (6%)       1 (2%)                                             
   Mesentery                                          (10)         (11)         (9)          (6)                                    
      Carcinoma, Metastatic, Uterus                                              1 (11%)                                            
      Fibrosarcoma                                                               1 (11%)                                            
      Hemangioma                                       1 (10%)                                                                      
      Squamous Cell Carcinoma, Metastatic, Vagina                                             1 (17%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (49)         (48)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
   Heart                                              (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Capsule, Adenoma                                 1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (49)         (49)         (48)                                   
      Pheochromocytoma Malignant                                                 2 (4%)                                             
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (47)         (48)         (47)                                   
      Pars Distalis, Adenoma                           7 (14%)      3 (6%)       4 (8%)       5 (11%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   2 (4%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Bilateral, Follicular Cell, Carcinoma                                                   1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (49)         (49)                                   
      Cystadenoma                                                   4 (8%)                    2 (4%)                                
      Fibrosarcoma, Metastatic, Uterus                                           1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       1 (2%)                                             
      Luteoma                                                       1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (49)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Fibrosarcoma                                                               1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       3 (6%)       1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
      Endometrium, Carcinoma                                                     1 (2%)       1 (2%)                                
      Endometrium, Polyp Stromal                       4 (8%)                    3 (6%)       2 (4%)                                
      Endometrium, Sarcoma Stromal                                                            1 (2%)                                
   Vagina                                             (49)         (44)         (48)         (48)                                   
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
      Squamous Cell Carcinoma                                                    5 (10%)      6 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (4)          (8)          (10)         (10)                                   
      Histiocytic Sarcoma                                           1 (13%)                                                         
      Iliac, Histiocytic Sarcoma                                    1 (13%)      1 (10%)                                            
      Inguinal, Histiocytic Sarcoma                                 1 (13%)                                                         
      Inguinal, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Vagina                                                                  1 (10%)                               
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                              1 (10%)                                            
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Lymph Node, Mesenteric                                     1 (10%)                                            
      Mediastinal, Histiocytic Sarcoma                              1 (13%)                                                         
      Renal, Histiocytic Sarcoma                                    1 (13%)      1 (10%)                                            
   Lymph Node, Mandibular                             (49)         (45)         (46)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (47)         (49)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                                                          
   Thymus                                             (47)         (46)         (46)         (45)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Histiocytic Sarcoma                                           2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
   Skin                                               (49)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma, Metastatic, Vagina                                             1 (2%)                                
                                                             Page   4                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       4 (8%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (49)                                   
      Osteosarcoma                                                  1 (2%)                    1 (2%)                                
   Skeletal Muscle                                    (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Fibrosarcoma, Metastatic, Uterus                                           1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
   Spinal Cord                                        (2)          (2)          (7)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                2 (4%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)          (1)                                                 
      Adenoma                                                       2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Vagina                                             1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (49)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Histiocytic Sarcoma                              3 (6%)       3 (6%)       1 (2%)                                             
      Lymphoma Malignant                              13 (26%)      8 (16%)     12 (24%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          39          38          36                                       
     Total Primary Neoplasms                           60          58          61          62                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          25          23          20                                       
     Total Benign Neoplasms                            28          33          26          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          23          28          28                                       
     Total Malignant Neoplasms                         32          25          35          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           5           1                                       
     Total Metastatic Neoplasm                          2           1          19           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14            5            9                                     
    Natural Death                                      1            7            4            6                                     
    Dosing Accident                                                 2            2                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           38           35                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (48)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                                         1 (2%)                                
   Intestine Small, Ileum                             (50)         (48)         (49)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoid Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                    1 (2%)                                                          
      Cholangiocarcinoma                                            1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                                         1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        2 (4%)       3 (6%)       3 (6%)       3 (6%)                                
      Hepatoblastoma                                   1 (2%)       1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                        12 (24%)     13 (26%)     15 (30%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       7 (14%)      2 (4%)       5 (10%)                               
      Hepatocellular Adenoma                          10 (20%)     12 (24%)     14 (28%)     14 (28%)                               
      Hepatocellular Adenoma, Multiple                 6 (12%)      4 (8%)       5 (10%)      4 (8%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Ito Cell Tumor Benign                                                      1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Mesentery                                          (1)          (2)          (1)                                                 
      Cholangiocarcinoma, Metastatic, Liver                         1 (50%)                                                         
      Sarcoma                                                       1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                 2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoid Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                    1 (2%)                                                          
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
      Bilateral, Capsule, Adenoma                                                             1 (2%)                                
      Capsule, Adenoma                                                                        2 (4%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (48)         (43)         (48)         (47)                                   
      Pars Distalis, Adenoma                                                                  1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
      Pars Intermedia, Carcinoma                                    1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Bilateral, Follicular Cell, Adenoma              1 (2%)                                                                       
      Follicular Cell, Adenoma                         3 (6%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Preputial Gland                                    (48)         (48)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Prostate                                           (50)         (50)         (48)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
   Lymph Node                                         (5)          (8)          (5)          (5)                                    
      Iliac, Histiocytic Sarcoma                       1 (20%)                                                                      
      Inguinal, Histiocytic Sarcoma                    1 (20%)                                                                      
      Pancreatic, Fibrous Histiocytoma, Metastatic,                                                                                 
           Lymph Node, Mesenteric                                   1 (13%)                                                         
      Pancreatic, Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (13%)                                                         
      Renal, Fibrous Histiocytoma, Metastatic,                                                                                      
           Lymph Node, Mesenteric                                                             1 (20%)                               
      Renal, Histiocytic Sarcoma                       1 (20%)      1 (13%)                                                         
   Lymph Node, Mandibular                             (46)         (47)         (49)         (46)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (48)         (50)         (47)                                   
      Fibrous Histiocytoma                                          1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                                         1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (45)         (40)         (42)         (43)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                                         1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
   Skeletal Muscle                                    (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     7 (14%)      3 (6%)       7 (14%)      7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       2 (4%)       6 (12%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)                    1 (2%)                                             
      Carcinoid Tumor Malignant, Metastatic,                                                                                        
          Uncertain Primary Site                                    1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Lymph Node,                                                                                 
           Mesenteric                                                                         1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       3 (6%)       2 (4%)       3 (6%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (1)          (5)                                    
      Adenoma                                          3 (100%)     3 (100%)     1 (100%)     2 (40%)                               
      Carcinoma                                                                               2 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       2 (4%)                                                          
      Lymphoma Malignant                               7 (14%)      8 (16%)      5 (10%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 89006-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/21/96  
Route: GAVAGE                                                                                                     Time: 09:09:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       500 U        500 U        500 U                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          41          42          47                                       
     Total Primary Neoplasms                           72          72          69          75                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          20          26          30                                       
     Total Benign Neoplasms                            36          25          33          36                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          32          29          33                                       
     Total Malignant Neoplasms                         36          47          36          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           8           2           5                                       
     Total Metastatic Neoplasm                          4          23           2          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.