TDMS Study 89029-05 Pathology Tables
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 MERGED REPORTS FINAL #3 Facility: I. I. T. Research Institute Chemical CAS #: ELECTROMAG Lock Date: 09/04/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Merge 001 001,011 SHAM CONTROL Merge 002 002,012 SHAM CONTROL Merge 003 003,013 .02 GAUSS Merge 004 004,014 .02 GAUSS Merge 005 005,015 2 GAUSS Merge 006 006,016 2 GAUSS Merge 007 009,019 10 GAUSS Merge 008 010,020 10 GAUSS Merge 009 007,017 10 GAUSS INTER Merge 010 008,018 10 GAUSS INTER a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 100 100 100 100 100 Early Deaths Natural Death 18 17 18 19 19 Moribund Sacrifice 22 15 22 18 23 Survivors Terminal Sacrifice 58 66 60 59 58 Natural Death 1 1 Moribund Sacrifice 1 1 1 Other 1 2 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (100) (100) (100) (100) (97) Polyp Adenomatous 1 (1%) Intestine Large, Rectum (99) (100) (100) (99) (100) Sarcoma 1 (1%) Schwannoma Malignant, Metastatic, Uterus 1 (1%) Intestine Large, Cecum (100) (98) (99) (100) (96) Intestine Small, Duodenum (97) (97) (96) (100) (96) Intestine Small, Ileum (94) (91) (93) (97) (91) Liver (100) (100) (100) (100) (100) Hemangiosarcoma, Metastatic, Spleen 1 (1%) Hepatocellular Adenoma 1 (1%) 1 (1%) Schwannoma Malignant, Metastatic, Uterus 1 (1%) Mesentery (11) (6) (5) (13) (16) Histiocytic Sarcoma, Metastatic, Skin 1 (17%) Leiomyoma 1 (8%) Schwannoma Malignant, Metastatic, Uterus 1 (9%) Pancreas (100) (100) (99) (100) (99) Acinus, Adenoma 1 (1%) 1 (1%) Salivary Glands (100) (99) (100) (100) (100) Stomach, Forestomach (100) (99) (99) (100) (100) Squamous Cell Papilloma 1 (1%) Stomach, Glandular (100) (100) (99) (100) (100) Tooth (2) (1) (1) (1) (1) Odontoma, Multiple 1 (100%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (100) (100) (100) (100) (100) Carcinosarcoma, Metastatic, Lung 1 (1%) Schwannoma Malignant 1 (1%) 2 (2%) 2 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (100) (100) (100) (100) (100) Adenoma 6 (6%) 2 (2%) 3 (3%) 1 (1%) Carcinoma 1 (1%) 1 (1%) Adrenal Medulla (96) (94) (94) (98) (97) Pheochromocytoma Malignant 1 (1%) 1 (1%) Pheochromocytoma Complex 2 (2%) Pheochromocytoma Benign 7 (7%) 8 (9%) 3 (3%) 2 (2%) 3 (3%) Bilateral, Pheochromocytoma Benign 1 (1%) Islets, Pancreatic (100) (100) (99) (100) (99) Adenoma 1 (1%) 3 (3%) 1 (1%) 1 (1%) Carcinoma 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%) Parathyroid Gland (88) (94) (91) (88) (92) Adenoma 1 (1%) 1 (1%) Pituitary Gland (99) (99) (98) (98) (98) Pars Distalis, Adenoma 61 (62%) 59 (60%) 68 (69%) 51 (52%) 62 (63%) Pars Distalis, Carcinoma 3 (3%) 1 (1%) 4 (4%) 2 (2%) 2 (2%) Pars Intermedia, Adenoma 3 (3%) 1 (1%) Thyroid Gland (100) (100) (100) (100) (100) Bilateral, C-Cell, Adenoma 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%) C-Cell, Adenoma 14 (14%) 19 (19%) 18 (18%) 19 (19%) 15 (15%) C-Cell, Carcinoma 5 (5%) 3 (3%) 3 (3%) 3 (3%) 6 (6%) Follicular Cell, Adenoma 1 (1%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (2) Abdominal, Chemodectoma Benign 1 (50%) Nasal, Schwannoma Malignant 1 (50%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (90) (96) (97) (96) (94) Adenoma 9 (10%) 13 (14%) 10 (10%) 15 (16%) 11 (12%) Hemangiosarcoma 1 (1%) Bilateral, Adenoma 2 (2%) 2 (2%) 1 (1%) 1 (1%) Ovary (100) (100) (100) (100) (99) Granulosa Cell Tumor Malignant 1 (1%) Page 3 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Granulosa Cell Tumor Benign 1 (1%) Granulosa-Theca Tumor Benign 1 (1%) Luteoma 1 (1%) Tubulostromal Adenoma 3 (3%) 1 (1%) 2 (2%) 1 (1%) 1 (1%) Bilateral, Granulosa Cell Tumor Benign 1 (1%) 1 (1%) Bilateral, Tubulostromal Adenoma 1 (1%) 1 (1%) Uterus (100) (100) (100) (100) (99) Fibroma 1 (1%) Leiomyosarcoma 2 (2%) 1 (1%) Schwannoma Malignant 2 (2%) Cervix, Polyp Stromal 1 (1%) Cervix, Schwannoma Malignant 1 (1%) Endometrium, Adenoma 2 (2%) Endometrium, Deciduoma Malignant 1 (1%) Endometrium, Polyp Stromal 13 (13%) 10 (10%) 13 (13%) 13 (13%) 10 (10%) Endometrium, Polyp Stromal, Multiple 1 (1%) 2 (2%) Endometrium, Sarcoma Stromal 2 (2%) Vagina (1) (1) (2) (2) Leiomyoma 1 (50%) Polyp 1 (50%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (100) (100) (100) (100) Lymph Node (16) (5) (5) (10) (18) Deep Cervical, Sarcoma, Metastatic, Skin 1 (6%) Lymph Node, Mandibular (100) (99) (100) (100) (100) Lymph Node, Mesenteric (100) (99) (99) (99) (99) Hemangiosarcoma 1 (1%) Spleen (100) (100) (100) (100) (99) Hemangiosarcoma 1 (1%) Thymus (95) (95) (92) (91) (92) Thymoma Benign 1 (1%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (100) (100) (100) (100) (100) Adenoma 1 (1%) 2 (2%) 1 (1%) 1 (1%) 2 (2%) Carcinoma 2 (2%) 7 (7%) 5 (5%) 1 (1%) 2 (2%) Carcinoma, Multiple 1 (1%) Fibroadenoma 36 (36%) 42 (42%) 32 (32%) 40 (40%) 27 (27%) Fibroadenoma, Multiple 20 (20%) 20 (20%) 22 (22%) 24 (24%) 24 (24%) Skin (100) (100) (100) (100) (100) Basal Cell Adenoma 1 (1%) 1 (1%) Hemangiopericytoma 1 (1%) Page 4 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Keratoacanthoma 1 (1%) 1 (1%) 2 (2%) 1 (1%) Squamous Cell Papilloma 1 (1%) Trichoepithelioma 2 (2%) Lip, Basal Cell Adenoma 1 (1%) Lip, Squamous Cell Papilloma 1 (1%) Subcutaneous Tissue, Fibroma 4 (4%) 5 (5%) 4 (4%) 1 (1%) Subcutaneous Tissue, Fibrosarcoma 1 (1%) 2 (2%) 1 (1%) Subcutaneous Tissue, Hemangiosarcoma 1 (1%) Subcutaneous Tissue, Histiocytic Sarcoma 1 (1%) Subcutaneous Tissue, Lipoma 1 (1%) Subcutaneous Tissue, Sarcoma 1 (1%) Subcutaneous Tissue, Schwannoma Malignant 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) (100) (100) Vertebra, Osteosarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (100) (100) (100) (100) Cerebellum, Meningioma Malignant 1 (1%) Cerebellum, Meninges, Granular Cell Tumor Malignant 1 (1%) Cerebrum, Astrocytoma Malignant 1 (1%) 2 (2%) Cerebrum, Glioma Malignant 1 (1%) Meninges, Granular Cell Tumor Benign 2 (2%) Spinal Cord (3) (4) (4) (1) (2) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (100) (100) (100) (100) Alveolar/Bronchiolar Adenoma 3 (3%) 5 (5%) 5 (5%) 1 (1%) Alveolar/Bronchiolar Carcinoma 1 (1%) Carcinoma, Metastatic, Zymbal's Gland 1 (1%) Carcinosarcoma 1 (1%) Chordoma, Metastatic, Uncertain Primary Site 1 (1%) Osteosarcoma, Metastatic, Bone 1 (1%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (1%) Nose (100) (100) (100) (100) (100) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (100) (100) (100) (100) (100) Zymbal's Gland (1) (1) Carcinoma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (100) (100) (100) (100) Nephroblastoma 1 (1%) Schwannoma Malignant, Metastatic, Uterus 1 (1%) Renal Tubule, Adenoma 1 (1%) Urinary Bladder (99) (97) (99) (99) (96) Transitional Epithelium, Carcinoma 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(100) *(100) *(100) *(100) *(100) Histiocytic Sarcoma 1 (1%) Leukemia Granulocytic 1 (1%) Leukemia Mononuclear 20 (20%) 18 (18%) 24 (24%) 25 (25%) 22 (22%) Lymphoma Malignant 1 (1%) Mesothelioma Malignant 1 (1%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 98 97 95 91 94 Total Primary Neoplasms 227 247 244 224 212 Total Animals with Benign Neoplasms 92 94 87 85 86 Total Benign Neoplasms 184 206 199 180 169 Total Animals with Malignant Neoplasms 40 41 38 39 40 Total Malignant Neoplasms 43 41 45 44 43 Total Animals with Metastatic Neoplasms 3 3 2 1 1 Total Metastatic Neoplasm 6 3 2 1 1 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 100 100 100 100 100 Early Deaths Moribund Sacrifice 29 32 32 36 33 Natural Death 14 21 21 16 7 Survivors Terminal Sacrifice 57 46 47 48 59 Other 1 1 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (100) (99) (99) (100) (99) Intestine Large, Rectum (99) (100) (100) (99) (100) Polyp Adenomatous 1 (1%) Intestine Large, Cecum (98) (99) (97) (100) (99) Sarcoma 1 (1%) Intestine Small, Duodenum (99) (94) (100) (100) (98) Intestine Small, Jejunum (91) (90) (95) (98) (98) Intestine Small, Ileum (94) (92) (97) (96) (97) Sarcoma 1 (1%) Liver (100) (100) (100) (100) (100) Hepatocellular Adenoma 1 (1%) 1 (1%) 2 (2%) 2 (2%) Hepatocellular Adenoma, Multiple 1 (1%) 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Osteosarcoma, Metastatic, Bone 1 (1%) Mesentery (17) (22) (27) (21) (16) Leiomyosarcoma, Metastatic, Spleen 1 (5%) Lipoma 1 (5%) Osteosarcoma, Metastatic, Kidney 1 (4%) Oral Mucosa (1) Squamous Cell Carcinoma 1 (100%) Pancreas (98) (99) (99) (99) (100) Mixed Tumor Benign 1 (1%) Acinus, Adenoma 3 (3%) 5 (5%) 6 (6%) 5 (5%) 2 (2%) Salivary Glands (99) (99) (100) (100) (100) Schwannoma Malignant, Metastatic, Skin 1 (1%) Stomach, Forestomach (100) (100) (100) (100) (100) Squamous Cell Papilloma 1 (1%) Stomach, Glandular (100) (100) (100) (100) (100) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Tooth (2) (1) (1) (1) (6) Odontoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (100) (100) (100) (100) (100) Osteosarcoma, Metastatic, Bone 1 (1%) Schwannoma Malignant 2 (2%) 1 (1%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (99) (100) (100) (100) (100) Adenoma 3 (3%) 1 (1%) 1 (1%) 1 (1%) Adrenal Medulla (98) (93) (100) (100) (95) Pheochromocytoma Malignant 2 (2%) 2 (2%) 2 (2%) Pheochromocytoma Complex 1 (1%) Pheochromocytoma Benign 19 (19%) 19 (20%) 15 (15%) 17 (17%) 25 (26%) Bilateral, Pheochromocytoma Benign 5 (5%) 3 (3%) 6 (6%) 6 (6%) 8 (8%) Islets, Pancreatic (99) (99) (99) (99) (100) Adenoma 3 (3%) 2 (2%) 5 (5%) 3 (3%) 2 (2%) Adenoma, Multiple 1 (1%) 1 (1%) Carcinoma 1 (1%) 2 (2%) 1 (1%) 3 (3%) Parathyroid Gland (85) (87) (93) (81) (89) Adenoma 1 (1%) 2 (2%) 2 (2%) Carcinoma, Metastatic, Skin 1 (1%) Carcinoma, Metastatic, Thyroid Gland 1 (1%) Pineal Gland (81) (84) (81) (79) (91) Pituitary Gland (98) (95) (97) (100) (98) Pars Distalis, Adenoma 34 (35%) 34 (36%) 28 (29%) 35 (35%) 40 (41%) Pars Distalis, Adenoma, Multiple 1 (1%) Pars Distalis, Carcinoma 1 (1%) 2 (2%) 3 (3%) Pars Intermedia, Adenoma 1 (1%) 1 (1%) 1 (1%) Pars Nervosa, Schwannoma Malignant 1 (1%) Thyroid Gland (99) (100) (100) (100) (100) Bilateral, C-Cell, Adenoma 2 (2%) 4 (4%) 1 (1%) 3 (3%) Bilateral, C-Cell, Carcinoma 1 (1%) C-Cell, Adenoma 15 (15%) 23 (23%) 22 (22%) 22 (22%) 15 (15%) C-Cell, Carcinoma 1 (1%) 6 (6%) 4 (4%) 2 (2%) 5 (5%) Follicular Cell, Adenoma 1 (1%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (1) (1) (1) Tissue NOS (3) (2) (1) (2) Abdominal, Carcinoma 1 (50%) Abdominal, Sarcoma 1 (33%) Mediastinum, Schwannoma Malignant 1 (33%) Thoracic, Squamous Cell Carcinoma, Page 9 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont Metastatic, Lung 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (100) (100) (100) (100) (100) Fibrosarcoma 1 (1%) Preputial Gland (100) (99) (100) (99) (100) Adenoma 10 (10%) 8 (8%) 10 (10%) 12 (12%) 9 (9%) Carcinoma 5 (5%) 2 (2%) Fibroma 1 (1%) Bilateral, Adenoma 3 (3%) 1 (1%) 1 (1%) 1 (1%) Prostate (100) (99) (100) (99) (100) Adenoma 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Seminal Vesicle (100) (99) (100) (99) (100) Adenoma 2 (2%) 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Testes (100) (100) (100) (100) (100) Bilateral, Interstitial Cell, Adenoma 82 (82%) 73 (73%) 72 (72%) 71 (71%) 67 (67%) Interstitial Cell, Adenoma 11 (11%) 17 (17%) 19 (19%) 20 (20%) 22 (22%) Interstitial Cell, Carcinoma 1 (1%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (100) (100) (99) (100) Lymph Node (15) (7) (7) (13) (8) Lymph Node, Mandibular (99) (99) (100) (100) (100) Schwannoma Malignant, Metastatic, Skin 1 (1%) Lymph Node, Mesenteric (100) (99) (100) (100) (100) Spleen (100) (100) (100) (100) (100) Fibroma 1 (1%) 1 (1%) Hemangiosarcoma 1 (1%) 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Sarcoma 1 (1%) Thymus (97) (94) (95) (90) (95) Thymoma Benign 2 (2%) 1 (1%) 1 (1%) Thymoma Malignant 2 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (99) (97) (100) (98) (95) Carcinoma 1 (1%) Fibroadenoma 6 (6%) 5 (5%) 11 (11%) 8 (8%) 8 (8%) Fibroadenoma, Multiple 1 (1%) 1 (1%) Page 10 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Skin (99) (100) (100) (100) (100) Basal Cell Adenoma 3 (3%) 3 (3%) 3 (3%) 2 (2%) Keratoacanthoma 10 (10%) 4 (4%) 11 (11%) 10 (10%) 8 (8%) Keratoacanthoma, Multiple 1 (1%) 1 (1%) Melanoma Malignant 1 (1%) Squamous Cell Carcinoma 1 (1%) Squamous Cell Papilloma 1 (1%) 2 (2%) 1 (1%) Trichoepithelioma 1 (1%) 5 (5%) Dermis, Fibroma 3 (3%) 2 (2%) 4 (4%) 5 (5%) 4 (4%) Dermis, Fibroma, Multiple 1 (1%) Lip, Basal Cell Adenoma 1 (1%) Lip, Squamous Cell Papilloma 1 (1%) Pinna, Melanoma Malignant 1 (1%) 1 (1%) Prepuce, Keratoacanthoma 1 (1%) 1 (1%) Prepuce, Squamous Cell Carcinoma 1 (1%) Sebaceous Gland, Adenoma 1 (1%) 2 (2%) 1 (1%) 1 (1%) Sebaceous Gland, Carcinoma 1 (1%) Subcutaneous Tissue, Fibroma 9 (9%) 6 (6%) 6 (6%) 10 (10%) 8 (8%) Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%) 1 (1%) 1 (1%) Subcutaneous Tissue, Leiomyosarcoma, Metastatic, Spleen 1 (1%) Subcutaneous Tissue, Lipoma 1 (1%) 2 (2%) 1 (1%) Subcutaneous Tissue, Melanoma Malignant 1 (1%) Subcutaneous Tissue, Sarcoma 1 (1%) 1 (1%) 3 (3%) 1 (1%) Subcutaneous Tissue, Schwannoma Malignant 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) (100) (100) Osteosarcoma 1 (1%) Femur, Osteosarcoma, Metastatic, Bone 1 (1%) Maxilla, Osteosarcoma 1 (1%) Skeletal Muscle (10) (6) (11) (4) (7) Sarcoma 1 (9%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (100) (100) (100) (100) Cerebellum, Schwannoma Malignant, Metastatic, Skin 1 (1%) Cerebrum, Astrocytoma Malignant 1 (1%) Cerebrum, Oligodendroglioma Malignant 1 (1%) 1 (1%) Cranial Nerve, Schwannoma Malignant 1 (1%) Spinal Cord (11) (6) (9) (4) (6) ____________________________________________________________________________________________________________________________________ Page 11 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (100) (100) (100) (100) Alveolar/Bronchiolar Adenoma 3 (3%) 5 (5%) 5 (5%) 4 (4%) Alveolar/Bronchiolar Carcinoma 2 (2%) Carcinoma 1 (1%) Carcinoma, Metastatic, Thyroid Gland 1 (1%) Chordoma, Metastatic, Uncertain Primary Site 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Melanoma Malignant, Metastatic, Skin 1 (1%) 1 (1%) Osteosarcoma, Metastatic, Bone 1 (1%) 1 (1%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (1%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (1%) Bronchus, Adenoma 1 (1%) Bronchus, Squamous Cell Carcinoma 1 (1%) Nose (100) (98) (100) (100) (100) Squamous Cell Carcinoma 1 (1%) Trachea (100) (100) (100) (100) (100) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (100) (100) (100) (100) (100) Adenoma 1 (1%) 1 (1%) Squamous Cell Carcinoma, Metastatic, Skin 1 (1%) Zymbal's Gland (1) (2) (1) (1) (1) Adenoma 1 (50%) Carcinoma 1 (100%) 1 (50%) 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (100) (100) (100) (100) Fibroma 1 (1%) Leiomyosarcoma, Metastatic, Spleen 1 (1%) Nephroblastoma 1 (1%) Osteosarcoma, Metastatic, Bone 1 (1%) Sarcoma 1 (1%) Capsule, Sarcoma 1 (1%) Pelvis, Transitional Epithelium, Carcinoma 1 (1%) Renal Tubule, Adenoma 1 (1%) Renal Tubule, Carcinoma 1 (1%) Urinary Bladder (99) (96) (100) (100) (99) Page 12 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont Transitional Epithelium, Papilloma 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(100) *(100) *(100) *(100) *(100) Leukemia Mononuclear 50 (50%) 44 (44%) 47 (47%) 50 (50%) 36 (36%) Lymphoma Malignant 1 (1%) Mesothelioma Malignant 4 (4%) 6 (6%) 5 (5%) 6 (6%) 4 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 13 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:28:43 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 100 98 98 100 98 Total Primary Neoplasms 298 304 317 327 303 Total Animals with Benign Neoplasms 99 97 97 98 94 Total Benign Neoplasms 229 230 245 253 233 Total Animals with Malignant Neoplasms 65 59 61 65 58 Total Malignant Neoplasms 69 74 72 74 70 Total Animals with Metastatic Neoplasms 1 5 2 4 2 Total Metastatic Neoplasm 1 5 4 15 4 Total Animals with Malignant Neoplasms 1 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 14 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------