National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5853

TDMS Study 89029-05 Pathology Tables

NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43

                                                    MERGED REPORTS FINAL #3




       Facility:  I. I. T. Research Institute

       Chemical CAS #:  ELECTROMAG

       Lock Date:  09/04/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     001   001,011                  SHAM     CONTROL
                               Merge     002   002,012                  SHAM     CONTROL
                               Merge     003   003,013                  .02      GAUSS
                               Merge     004   004,014                  .02      GAUSS
                               Merge     005   005,015                  2 GAUSS
                               Merge     006   006,016                  2 GAUSS
                               Merge     007   009,019                  10 GAUSS
                               Merge     008   010,020                  10 GAUSS
                               Merge     009   007,017                  10 GAUSS   INTER
                               Merge     010   008,018                  10 GAUSS   INTER

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                         100          100          100          100          100                        
  Early Deaths                                                                                                                      
    Natural Death                                     18           17           18           19           19                        
    Moribund Sacrifice                                22           15           22           18           23                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                58           66           60           59           58                        
    Natural Death                                                   1                         1                                     
    Moribund Sacrifice                                 1            1                         1                                     
  Other                                                1                                      2                                     

  Animals Examined Microscopically                   100          100          100          100          100                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (100)        (100)        (100)        (100)        (97)                      
      Polyp Adenomatous                                                          1 (1%)                                             
   Intestine Large, Rectum                            (99)         (100)        (100)        (99)         (100)                     
      Sarcoma                                          1 (1%)                                                                       
      Schwannoma Malignant, Metastatic, Uterus         1 (1%)                                                                       
   Intestine Large, Cecum                             (100)        (98)         (99)         (100)        (96)                      
   Intestine Small, Duodenum                          (97)         (97)         (96)         (100)        (96)                      
   Intestine Small, Ileum                             (94)         (91)         (93)         (97)         (91)                      
   Liver                                              (100)        (100)        (100)        (100)        (100)                     
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (1%)                   
      Hepatocellular Adenoma                                                                  1 (1%)       1 (1%)                   
      Schwannoma Malignant, Metastatic, Uterus         1 (1%)                                                                       
   Mesentery                                          (11)         (6)          (5)          (13)         (16)                      
      Histiocytic Sarcoma, Metastatic, Skin                         1 (17%)                                                         
      Leiomyoma                                                                               1 (8%)                                
      Schwannoma Malignant, Metastatic, Uterus         1 (9%)                                                                       
   Pancreas                                           (100)        (100)        (99)         (100)        (99)                      
      Acinus, Adenoma                                               1 (1%)                    1 (1%)                                
   Salivary Glands                                    (100)        (99)         (100)        (100)        (100)                     
   Stomach, Forestomach                               (100)        (99)         (99)         (100)        (100)                     
      Squamous Cell Papilloma                                                                 1 (1%)                                
   Stomach, Glandular                                 (100)        (100)        (99)         (100)        (100)                     
   Tooth                                              (2)          (1)          (1)          (1)          (1)                       
      Odontoma, Multiple                                            1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (100)        (100)        (100)        (100)        (100)                     
      Carcinosarcoma, Metastatic, Lung                 1 (1%)                                                                       
      Schwannoma Malignant                                          1 (1%)       2 (2%)                    2 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (100)        (100)        (100)        (100)        (100)                     
      Adenoma                                          6 (6%)       2 (2%)       3 (3%)       1 (1%)                                
      Carcinoma                                        1 (1%)                    1 (1%)                                             
   Adrenal Medulla                                    (96)         (94)         (94)         (98)         (97)                      
      Pheochromocytoma Malignant                                    1 (1%)       1 (1%)                                             
      Pheochromocytoma Complex                                                                             2 (2%)                   
      Pheochromocytoma Benign                          7 (7%)       8 (9%)       3 (3%)       2 (2%)       3 (3%)                   
      Bilateral, Pheochromocytoma Benign                                         1 (1%)                                             
   Islets, Pancreatic                                 (100)        (100)        (99)         (100)        (99)                      
      Adenoma                                          1 (1%)                    3 (3%)       1 (1%)       1 (1%)                   
      Carcinoma                                        1 (1%)       1 (1%)       1 (1%)       1 (1%)       1 (1%)                   
   Parathyroid Gland                                  (88)         (94)         (91)         (88)         (92)                      
      Adenoma                                          1 (1%)                    1 (1%)                                             
   Pituitary Gland                                    (99)         (99)         (98)         (98)         (98)                      
      Pars Distalis, Adenoma                          61 (62%)     59 (60%)     68 (69%)     51 (52%)     62 (63%)                  
      Pars Distalis, Carcinoma                         3 (3%)       1 (1%)       4 (4%)       2 (2%)       2 (2%)                   
      Pars Intermedia, Adenoma                                      3 (3%)       1 (1%)                                             
   Thyroid Gland                                      (100)        (100)        (100)        (100)        (100)                     
      Bilateral, C-Cell, Adenoma                       1 (1%)       1 (1%)       1 (1%)       1 (1%)       1 (1%)                   
      C-Cell, Adenoma                                 14 (14%)     19 (19%)     18 (18%)     19 (19%)     15 (15%)                  
      C-Cell, Carcinoma                                5 (5%)       3 (3%)       3 (3%)       3 (3%)       6 (6%)                   
      Follicular Cell, Adenoma                                      1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (2)                                    
      Abdominal, Chemodectoma Benign                                                          1 (50%)                               
      Nasal, Schwannoma Malignant                                                             1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (90)         (96)         (97)         (96)         (94)                      
      Adenoma                                          9 (10%)     13 (14%)     10 (10%)     15 (16%)     11 (12%)                  
      Hemangiosarcoma                                                            1 (1%)                                             
      Bilateral, Adenoma                               2 (2%)       2 (2%)       1 (1%)       1 (1%)                                
   Ovary                                              (100)        (100)        (100)        (100)        (99)                      
      Granulosa Cell Tumor Malignant                                                                       1 (1%)                   

                                                             Page   3                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Granulosa Cell Tumor Benign                                                1 (1%)                                             
      Granulosa-Theca Tumor Benign                                  1 (1%)                                                          
      Luteoma                                          1 (1%)                                                                       
      Tubulostromal Adenoma                            3 (3%)       1 (1%)       2 (2%)       1 (1%)       1 (1%)                   
      Bilateral, Granulosa Cell Tumor Benign                        1 (1%)                                 1 (1%)                   
      Bilateral, Tubulostromal Adenoma                              1 (1%)                                 1 (1%)                   
   Uterus                                             (100)        (100)        (100)        (100)        (99)                      
      Fibroma                                                       1 (1%)                                                          
      Leiomyosarcoma                                   2 (2%)       1 (1%)                                                          
      Schwannoma Malignant                             2 (2%)                                                                       
      Cervix, Polyp Stromal                                         1 (1%)                                                          
      Cervix, Schwannoma Malignant                     1 (1%)                                                                       
      Endometrium, Adenoma                                                                                 2 (2%)                   
      Endometrium, Deciduoma Malignant                              1 (1%)                                                          
      Endometrium, Polyp Stromal                      13 (13%)     10 (10%)     13 (13%)     13 (13%)     10 (10%)                  
      Endometrium, Polyp Stromal, Multiple                          1 (1%)                                 2 (2%)                   
      Endometrium, Sarcoma Stromal                                  2 (2%)                                                          
   Vagina                                                          (1)          (1)          (2)          (2)                       
      Leiomyoma                                                                               1 (50%)                               
      Polyp                                                                                                1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (100)        (100)        (100)        (100)        (100)                     
   Lymph Node                                         (16)         (5)          (5)          (10)         (18)                      
      Deep Cervical, Sarcoma, Metastatic, Skin         1 (6%)                                                                       
   Lymph Node, Mandibular                             (100)        (99)         (100)        (100)        (100)                     
   Lymph Node, Mesenteric                             (100)        (99)         (99)         (99)         (99)                      
      Hemangiosarcoma                                               1 (1%)                                                          
   Spleen                                             (100)        (100)        (100)        (100)        (99)                      
      Hemangiosarcoma                                                                                      1 (1%)                   
   Thymus                                             (95)         (95)         (92)         (91)         (92)                      
      Thymoma Benign                                                             1 (1%)       1 (1%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (100)        (100)        (100)        (100)        (100)                     
      Adenoma                                          1 (1%)       2 (2%)       1 (1%)       1 (1%)       2 (2%)                   
      Carcinoma                                        2 (2%)       7 (7%)       5 (5%)       1 (1%)       2 (2%)                   
      Carcinoma, Multiple                                                                     1 (1%)                                
      Fibroadenoma                                    36 (36%)     42 (42%)     32 (32%)     40 (40%)     27 (27%)                  
      Fibroadenoma, Multiple                          20 (20%)     20 (20%)     22 (22%)     24 (24%)     24 (24%)                  
   Skin                                               (100)        (100)        (100)        (100)        (100)                     
      Basal Cell Adenoma                                            1 (1%)                                 1 (1%)                   
      Hemangiopericytoma                                            1 (1%)                                                          

                                                             Page   4                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  1 (1%)       1 (1%)       2 (2%)       1 (1%)                                
      Squamous Cell Papilloma                                                                              1 (1%)                   
      Trichoepithelioma                                                          2 (2%)                                             
      Lip, Basal Cell Adenoma                                                    1 (1%)                                             
      Lip, Squamous Cell Papilloma                                               1 (1%)                                             
      Subcutaneous Tissue, Fibroma                     4 (4%)       5 (5%)       4 (4%)                    1 (1%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                 2 (2%)       1 (1%)                   
      Subcutaneous Tissue, Hemangiosarcoma                          1 (1%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (1%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (1%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (1%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (1%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (100)        (100)        (100)        (100)        (100)                     
      Vertebra, Osteosarcoma                                        1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (100)        (100)        (100)        (100)                     
      Cerebellum, Meningioma Malignant                                                        1 (1%)                                
      Cerebellum, Meninges, Granular Cell Tumor                                                                                     
          Malignant                                                              1 (1%)                                             
      Cerebrum, Astrocytoma Malignant                  1 (1%)                                 2 (2%)                                
      Cerebrum, Glioma Malignant                       1 (1%)                                                                       
      Meninges, Granular Cell Tumor Benign                          2 (2%)                                                          
   Spinal Cord                                        (3)          (4)          (4)          (1)          (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (100)        (100)        (100)        (100)                     
      Alveolar/Bronchiolar Adenoma                     3 (3%)       5 (5%)       5 (5%)       1 (1%)                                
      Alveolar/Bronchiolar Carcinoma                                                          1 (1%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (1%)                                
      Carcinosarcoma                                   1 (1%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site                               1 (1%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (1%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (1%)                                                          
   Nose                                               (100)        (100)        (100)        (100)        (100)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   5                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (100)        (100)        (100)        (100)        (100)                     
   Zymbal's Gland                                                                            (1)          (1)                       
      Carcinoma                                                                               1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (100)        (100)        (100)        (100)                     
      Nephroblastoma                                                                                       1 (1%)                   
      Schwannoma Malignant, Metastatic, Uterus         1 (1%)                                                                       
      Renal Tubule, Adenoma                                                                   1 (1%)                                
   Urinary Bladder                                    (99)         (97)         (99)         (99)         (96)                      
      Transitional Epithelium, Carcinoma                                         1 (1%)       1 (1%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(100)       *(100)       *(100)       *(100)       *(100)                     
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Leukemia Granulocytic                                                                   1 (1%)                                
      Leukemia Mononuclear                            20 (20%)     18 (18%)     24 (24%)     25 (25%)     22 (22%)                  
      Lymphoma Malignant                                                                                   1 (1%)                   
      Mesothelioma Malignant                                                     1 (1%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            98          97          95          91          94                           
     Total Primary Neoplasms                          227         247         244         224         212                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 92          94          87          85          86                           
     Total Benign Neoplasms                           184         206         199         180         169                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              40          41          38          39          40                           
     Total Malignant Neoplasms                         43          41          45          44          43                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           2           1           1                           
     Total Metastatic Neoplasm                          6           3           2           1           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                         100          100          100          100          100                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                29           32           32           36           33                        
    Natural Death                                     14           21           21           16            7                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                57           46           47           48           59                        
  Other                                                             1                                      1                        

  Animals Examined Microscopically                   100          100          100          100          100                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (100)        (99)         (99)         (100)        (99)                      
   Intestine Large, Rectum                            (99)         (100)        (100)        (99)         (100)                     
      Polyp Adenomatous                                                          1 (1%)                                             
   Intestine Large, Cecum                             (98)         (99)         (97)         (100)        (99)                      
      Sarcoma                                                                                 1 (1%)                                
   Intestine Small, Duodenum                          (99)         (94)         (100)        (100)        (98)                      
   Intestine Small, Jejunum                           (91)         (90)         (95)         (98)         (98)                      
   Intestine Small, Ileum                             (94)         (92)         (97)         (96)         (97)                      
      Sarcoma                                                                                              1 (1%)                   
   Liver                                              (100)        (100)        (100)        (100)        (100)                     
      Hepatocellular Adenoma                           1 (1%)       1 (1%)       2 (2%)                    2 (2%)                   
      Hepatocellular Adenoma, Multiple                              1 (1%)       1 (1%)                                             
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
   Mesentery                                          (17)         (22)         (27)         (21)         (16)                      
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (5%)                                
      Lipoma                                                                                  1 (5%)                                
      Osteosarcoma, Metastatic, Kidney                                           1 (4%)                                             
   Oral Mucosa                                                                                            (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
   Pancreas                                           (98)         (99)         (99)         (99)         (100)                     
      Mixed Tumor Benign                                            1 (1%)                                                          
      Acinus, Adenoma                                  3 (3%)       5 (5%)       6 (6%)       5 (5%)       2 (2%)                   
   Salivary Glands                                    (99)         (99)         (100)        (100)        (100)                     
      Schwannoma Malignant, Metastatic, Skin                                                               1 (1%)                   
   Stomach, Forestomach                               (100)        (100)        (100)        (100)        (100)                     
      Squamous Cell Papilloma                          1 (1%)                                                                       
   Stomach, Glandular                                 (100)        (100)        (100)        (100)        (100)                     
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
   Tooth                                              (2)          (1)          (1)          (1)          (6)                       
      Odontoma                                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________

                                                             Page   8                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (100)        (100)        (100)        (100)        (100)                     
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
      Schwannoma Malignant                             2 (2%)       1 (1%)       1 (1%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (99)         (100)        (100)        (100)        (100)                     
      Adenoma                                                       3 (3%)       1 (1%)       1 (1%)       1 (1%)                   
   Adrenal Medulla                                    (98)         (93)         (100)        (100)        (95)                      
      Pheochromocytoma Malignant                       2 (2%)       2 (2%)                                 2 (2%)                   
      Pheochromocytoma Complex                                                   1 (1%)                                             
      Pheochromocytoma Benign                         19 (19%)     19 (20%)     15 (15%)     17 (17%)     25 (26%)                  
      Bilateral, Pheochromocytoma Benign               5 (5%)       3 (3%)       6 (6%)       6 (6%)       8 (8%)                   
   Islets, Pancreatic                                 (99)         (99)         (99)         (99)         (100)                     
      Adenoma                                          3 (3%)       2 (2%)       5 (5%)       3 (3%)       2 (2%)                   
      Adenoma, Multiple                                             1 (1%)       1 (1%)                                             
      Carcinoma                                        1 (1%)       2 (2%)                    1 (1%)       3 (3%)                   
   Parathyroid Gland                                  (85)         (87)         (93)         (81)         (89)                      
      Adenoma                                                       1 (1%)       2 (2%)       2 (2%)                                
      Carcinoma, Metastatic, Skin                                   1 (1%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (1%)                                                          
   Pineal Gland                                       (81)         (84)         (81)         (79)         (91)                      
   Pituitary Gland                                    (98)         (95)         (97)         (100)        (98)                      
      Pars Distalis, Adenoma                          34 (35%)     34 (36%)     28 (29%)     35 (35%)     40 (41%)                  
      Pars Distalis, Adenoma, Multiple                              1 (1%)                                                          
      Pars Distalis, Carcinoma                                      1 (1%)       2 (2%)                    3 (3%)                   
      Pars Intermedia, Adenoma                                      1 (1%)       1 (1%)       1 (1%)                                
      Pars Nervosa, Schwannoma Malignant                                                      1 (1%)                                
   Thyroid Gland                                      (99)         (100)        (100)        (100)        (100)                     
      Bilateral, C-Cell, Adenoma                                    2 (2%)       4 (4%)       1 (1%)       3 (3%)                   
      Bilateral, C-Cell, Carcinoma                                  1 (1%)                                                          
      C-Cell, Adenoma                                 15 (15%)     23 (23%)     22 (22%)     22 (22%)     15 (15%)                  
      C-Cell, Carcinoma                                1 (1%)       6 (6%)       4 (4%)       2 (2%)       5 (5%)                   
      Follicular Cell, Adenoma                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)                       (1)                                    
   Tissue NOS                                         (3)          (2)                       (1)          (2)                       
      Abdominal, Carcinoma                                          1 (50%)                                                         
      Abdominal, Sarcoma                               1 (33%)                                                                      
      Mediastinum, Schwannoma Malignant                1 (33%)                                                                      
      Thoracic, Squamous Cell Carcinoma,                                                                                            

                                                             Page   9                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENERAL BODY SYSTEM - cont                                                                                                          
          Metastatic, Lung                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (100)        (100)        (100)        (100)        (100)                     
      Fibrosarcoma                                                  1 (1%)                                                          
   Preputial Gland                                    (100)        (99)         (100)        (99)         (100)                     
      Adenoma                                         10 (10%)      8 (8%)      10 (10%)     12 (12%)      9 (9%)                   
      Carcinoma                                                                  5 (5%)                    2 (2%)                   
      Fibroma                                                                    1 (1%)                                             
      Bilateral, Adenoma                               3 (3%)       1 (1%)                    1 (1%)       1 (1%)                   
   Prostate                                           (100)        (99)         (100)        (99)         (100)                     
      Adenoma                                                                                 1 (1%)                                
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
   Seminal Vesicle                                    (100)        (99)         (100)        (99)         (100)                     
      Adenoma                                                                    2 (2%)                    1 (1%)                   
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
   Testes                                             (100)        (100)        (100)        (100)        (100)                     
      Bilateral, Interstitial Cell, Adenoma           82 (82%)     73 (73%)     72 (72%)     71 (71%)     67 (67%)                  
      Interstitial Cell, Adenoma                      11 (11%)     17 (17%)     19 (19%)     20 (20%)     22 (22%)                  
      Interstitial Cell, Carcinoma                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (100)        (100)        (100)        (99)         (100)                     
   Lymph Node                                         (15)         (7)          (7)          (13)         (8)                       
   Lymph Node, Mandibular                             (99)         (99)         (100)        (100)        (100)                     
      Schwannoma Malignant, Metastatic, Skin                                                               1 (1%)                   
   Lymph Node, Mesenteric                             (100)        (99)         (100)        (100)        (100)                     
   Spleen                                             (100)        (100)        (100)        (100)        (100)                     
      Fibroma                                                                    1 (1%)                    1 (1%)                   
      Hemangiosarcoma                                                            1 (1%)                    1 (1%)                   
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
      Sarcoma                                                                    1 (1%)                                             
   Thymus                                             (97)         (94)         (95)         (90)         (95)                      
      Thymoma Benign                                   2 (2%)       1 (1%)       1 (1%)                                             
      Thymoma Malignant                                             2 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (99)         (97)         (100)        (98)         (95)                      
      Carcinoma                                                     1 (1%)                                                          
      Fibroadenoma                                     6 (6%)       5 (5%)      11 (11%)      8 (8%)       8 (8%)                   
      Fibroadenoma, Multiple                                        1 (1%)                    1 (1%)                                

                                                             Page  10                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
   Skin                                               (99)         (100)        (100)        (100)        (100)                     
      Basal Cell Adenoma                               3 (3%)                    3 (3%)       3 (3%)       2 (2%)                   
      Keratoacanthoma                                 10 (10%)      4 (4%)      11 (11%)     10 (10%)      8 (8%)                   
      Keratoacanthoma, Multiple                                     1 (1%)                    1 (1%)                                
      Melanoma Malignant                                                                                   1 (1%)                   
      Squamous Cell Carcinoma                                                                              1 (1%)                   
      Squamous Cell Papilloma                          1 (1%)       2 (2%)       1 (1%)                                             
      Trichoepithelioma                                             1 (1%)                    5 (5%)                                
      Dermis, Fibroma                                  3 (3%)       2 (2%)       4 (4%)       5 (5%)       4 (4%)                   
      Dermis, Fibroma, Multiple                                     1 (1%)                                                          
      Lip, Basal Cell Adenoma                                                                              1 (1%)                   
      Lip, Squamous Cell Papilloma                                                            1 (1%)                                
      Pinna, Melanoma Malignant                                                               1 (1%)       1 (1%)                   
      Prepuce, Keratoacanthoma                                                                1 (1%)       1 (1%)                   
      Prepuce, Squamous Cell Carcinoma                                                                     1 (1%)                   
      Sebaceous Gland, Adenoma                                      1 (1%)       2 (2%)       1 (1%)       1 (1%)                   
      Sebaceous Gland, Carcinoma                       1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                     9 (9%)       6 (6%)       6 (6%)      10 (10%)      8 (8%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)       1 (1%)       1 (1%)                    1 (1%)                   
      Subcutaneous Tissue, Leiomyosarcoma,                                                                                          
          Metastatic, Spleen                                                                  1 (1%)                                
      Subcutaneous Tissue, Lipoma                      1 (1%)                                 2 (2%)       1 (1%)                   
      Subcutaneous Tissue, Melanoma Malignant                       1 (1%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (1%)       1 (1%)       3 (3%)       1 (1%)                   
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (1%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (100)        (100)        (100)        (100)        (100)                     
      Osteosarcoma                                                                            1 (1%)                                
      Femur, Osteosarcoma, Metastatic, Bone                                      1 (1%)                                             
      Maxilla, Osteosarcoma                                                      1 (1%)                                             
   Skeletal Muscle                                    (10)         (6)          (11)         (4)          (7)                       
      Sarcoma                                                                    1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (100)        (100)        (100)        (100)                     
      Cerebellum, Schwannoma Malignant, Metastatic,                                                                                 
           Skin                                                                                            1 (1%)                   
      Cerebrum, Astrocytoma Malignant                  1 (1%)                                                                       
      Cerebrum, Oligodendroglioma Malignant            1 (1%)                                              1 (1%)                   
      Cranial Nerve, Schwannoma Malignant                                                     1 (1%)                                
   Spinal Cord                                        (11)         (6)          (9)          (4)          (6)                       
____________________________________________________________________________________________________________________________________

                                                             Page  11                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (100)        (100)        (100)        (100)                     
      Alveolar/Bronchiolar Adenoma                     3 (3%)       5 (5%)       5 (5%)       4 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                2 (2%)                                                          
      Carcinoma                                                                               1 (1%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (1%)                                                          
      Chordoma, Metastatic, Uncertain Primary Site                                                         1 (1%)                   
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
      Melanoma Malignant, Metastatic, Skin                          1 (1%)                    1 (1%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (1%)       1 (1%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (1%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (1%)                                                          
      Bronchus, Adenoma                                1 (1%)                                                                       
      Bronchus, Squamous Cell Carcinoma                                                       1 (1%)                                
   Nose                                               (100)        (98)         (100)        (100)        (100)                     
      Squamous Cell Carcinoma                                                                              1 (1%)                   
   Trachea                                            (100)        (100)        (100)        (100)        (100)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (100)        (100)        (100)        (100)        (100)                     
      Adenoma                                                       1 (1%)       1 (1%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (1%)                                
   Zymbal's Gland                                     (1)          (2)          (1)          (1)          (1)                       
      Adenoma                                                       1 (50%)                                                         
      Carcinoma                                        1 (100%)     1 (50%)                   1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (100)        (100)        (100)        (100)                     
      Fibroma                                          1 (1%)                                                                       
      Leiomyosarcoma, Metastatic, Spleen                                                      1 (1%)                                
      Nephroblastoma                                                                                       1 (1%)                   
      Osteosarcoma, Metastatic, Bone                                             1 (1%)                                             
      Sarcoma                                                                    1 (1%)                                             
      Capsule, Sarcoma                                 1 (1%)                                                                       
      Pelvis, Transitional Epithelium, Carcinoma                                              1 (1%)                                
      Renal Tubule, Adenoma                                                                   1 (1%)                                
      Renal Tubule, Carcinoma                                                                 1 (1%)                                
   Urinary Bladder                                    (99)         (96)         (100)        (100)        (99)                      

                                                             Page  12                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma               1 (1%)                                 1 (1%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(100)       *(100)       *(100)       *(100)       *(100)                     
      Leukemia Mononuclear                            50 (50%)     44 (44%)     47 (47%)     50 (50%)     36 (36%)                  
      Lymphoma Malignant                                                                                   1 (1%)                   
      Mesothelioma Malignant                           4 (4%)       6 (6%)       5 (5%)       6 (6%)       4 (4%)                   
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  13                                                               
NTP Experiment-Test: 89029-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MAGNETIC FIELDS (EMF)                                   Date: 01/27/98  
Route: MAGNETIC FIELDS                                                                                            Time: 16:28:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     SHAM         .02          2 GAUSS      10 GAUSS     10 GAUSS                     
                                                    CONTROL      GAUSS                                    INTER                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)           100          98          98         100          98                           
     Total Primary Neoplasms                          298         304         317         327         303                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 99          97          97          98          94                           
     Total Benign Neoplasms                           229         230         245         253         233                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              65          59          61          65          58                           
     Total Malignant Neoplasms                         69          74          72          74          70                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           5           2           4           2                           
     Total Metastatic Neoplasm                          1           5           4          15           4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                               1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  14                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.