TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98
EXPERIMENT: 89029 TEST: 05 TIME: 10:45:12
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98
EXPERIMENT: 89029 TEST: 05 TIME: 10:45:12
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF MAGNETIC FIELDS (EMF)
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Vacuolization Cytoplasmic Diffuse
Bone Marrow Hemorrhage
Harderian Gland Atrophy Focal
Intestine Small, Ileum: Peyer's Patch Hyperplasia Lymphoid
Islets, Pancreatic Hyperplasia Focal
Liver Basophilic Focus
Degeneration Cystic Focal
Liver: Bile Duct Hyperplasia
Lung Infiltration Cellular Histiocyte
Infiltration Cellular Lymphocyte
Metaplasia Focal Osseous
Lymph Node, Mandibular Hemorrhage
Infiltration Cellular Histiocyte
Lymph Node, Mesenteric Infiltration Cellular Histiocyte
Mammary Gland Galactocele
Mammary Gland: Epithelium Hyperplasia
Nose Inflammation Chronic
Nose: Olfactory Epithelium Cytoplasmic Alteration
Pancreas Infiltration Cellular Lymphocyte
Pineal Gland Mineralization
Pituitary Gland: Pars Distalis Cyst
Prostate Atrophy
Inflammation Acute
Inflammation Chronic
Spleen Congestion
Fibrosis
Stomach, Glandular Erosion Focal
Testes: Interstitial Cell Hyperplasia Focal
Thymus Atrophy
Thyroid Gland Ultimobranchial Cyst
Trachea Inflammation Chronic
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Hyperplasia Focal
Hypertrophy Focal
Bone Marrow Depletion Cellular
Bone: Cranium Hyperostosis
Bone: Femur Hyperostosis
Bone: Turbinate Hyperostosis
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98
EXPERIMENT: 89029 TEST: 05 TIME: 10:45:12
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG
Clitoral Gland Cyst
Harderian Gland Infiltration Cellular Lymphocyte
Heart Cardiomyopathy
Intestine Small, Ileum: Peyer's Patch Hyperplasia Lymphoid
Kidney Nephropathy
Kidney: Renal Tubule Pigmentation
Liver Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Infiltration Cellular Histiocyte
Lung Infiltration Cellular Histiocyte
Infiltration Cellular Lymphocyte
Lung: Interstitium Inflammation Chronic
Lymph Node, Mandibular Congestion
Degeneration Cystic
Hyperplasia Lymphoid
Mammary Gland Cyst
Mesentery: Fat Necrosis
Nose: Nasolacrimal Duct Inflammation Chronic
Nose: Olfactory Epithelium Cytoplasmic Alteration
Pancreas: Acinus Atrophy Focal
Pituitary Gland: Pars Distalis Angiectasis Focal
Stomach, Forestomach: Epithelium Hyperplasia
Stomach, Glandular: Glands Cyst
Thymus Hemorrhage
Thyroid Gland: C-Cell Hyperplasia
Hyperplasia Focal
Trachea Inflammation Chronic
===============================================================
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/99 (5%) 12/100 (12%) 2/100 (2%) 3/100 (3%) |58/100 (58%) 55/100 (55%) 50/100 (50%) 59/100 (59%) |
|POLY-3 ADJUSTED (b)| 5.8% 14.7% 2.4% 3.7% |65.8% 60.7% 55.7% 65.8% |
|TERMINAL (d) | 4/57 (7%) 10/46 (22%) 2/47 (4%) 3/48 (6%) |45/59 (76%) 47/68 (69%) 41/60 (68%) 43/61 (71%) |
|FIRST INCIDENCE | 670 624 736 (T) 736 (T) |613 641 617 522 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.081N P=0.024 * P=0.292N P=0.448N |P=0.232 P=0.081N P=0.108N P=0.498N |
|POLY 3 | P=0.077N P=0.049 * P=0.230N P=0.390N |P=0.295 P=0.281N P=0.098N P=0.563 |
|POLY 1.5 | P=0.072N P=0.055 P=0.225N P=0.376N |P=0.257 P=0.326N P=0.125N P=0.486 |
|POLY 6 | P=0.081N P=0.044 * P=0.234N P=0.403N |P=0.396 P=0.230N P=0.069N P=0.432N |
|LOGISTIC REGRESSION| P=0.075N P=0.042 * P=0.232N P=0.401N |P=0.233 P=0.129N P=0.064N P=0.508 |
|COCH-ARM / FISHERS | P=0.068N P=0.066 P=0.218N P=0.355N |P=0.313 P=0.388N P=0.160N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 7/100 (7%) 5/100 (5%) 2/100 (2%) |2/100 (2%) 4/100 (4%) 6/100 (6%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 3.5% 8.6% 6.0% 2.5% |2.3% 4.5% 6.8% 4.7% |
|TERMINAL (d) | 1/57 (2%) 6/46 (13%) 2/47 (4%) 2/48 (4%) |1/59 (2%) 3/68 (4%) 3/60 (5%) 4/61 (7%) |
|FIRST INCIDENCE | 674 624 672 736 (T) |673 674 639 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.176N P=0.104 P=0.322 P=0.562N |P=0.486 P=0.398 P=0.157 P=0.356 |
|POLY 3 | P=0.173N P=0.144 P=0.347 P=0.526N |P=0.479 P=0.360 P=0.148 P=0.335 |
|POLY 1.5 | P=0.164N P=0.153 P=0.354 P=0.514N |P=0.477 P=0.351 P=0.143 P=0.331 |
|POLY 6 | P=0.181N P=0.135 P=0.341 P=0.538N |P=0.489 P=0.372 P=0.154 P=0.347 |
|LOGISTIC REGRESSION| P=0.167N P=0.140 P=0.346 P=0.530N |P=0.485 P=0.362 P=0.143 P=0.356 |
|COCH-ARM / FISHERS | P=0.152N P=0.170 P=0.366 P=0.495N |P=0.500 P=0.341 P=0.140 P=0.341 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/99 (12%) 15/100 (15%) 9/100 (9%) 11/100 (11%)|11/100 (11%) 24/100 (24%) 12/100 (12%) 10/100 (10%) |
|POLY-3 ADJUSTED (b)| 13.8% 18.2% 10.8% 13.5% |12.7% 26.2% 13.7% 11.8% |
|TERMINAL (d) | 8/57 (14%) 10/46 (22%) 8/47 (17%) 8/48 (17%) |6/59 (10%) 18/68 (27%) 10/60 (17%) 10/61 (16%) |
|FIRST INCIDENCE | 573 619 726 565 |494 532 656 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.430N P=0.184 P=0.467N P=0.529 |P=0.082N P=0.037 * P=0.527 P=0.470N |
|POLY 3 | P=0.409N P=0.287 P=0.354N P=0.563N |P=0.081N P=0.017 * P=0.510 P=0.523N |
|POLY 1.5 | P=0.390N P=0.310 P=0.337N P=0.534N |P=0.081N P=0.014 * P=0.504 P=0.527N |
|POLY 6 | P=0.429N P=0.264 P=0.371N P=0.587 |P=0.076N P=0.020 * P=0.520 P=0.507N |
|LOGISTIC REGRESSION| P=0.411N P=0.286 P=0.346N P=0.562N |P=0.078N P=0.014 * P=0.521 P=0.500N |
|COCH-ARM / FISHERS | P=0.363N P=0.350 P=0.314N P=0.490N |P=0.069N P=0.012 * P=0.500 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 3/100 (3%) 6/100 (6%) 3/100 (3%) |3/100 (3%) 0/100 (0%) 1/100 (1%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 3.5% 3.7% 7.2% 3.7% |3.5% 0.0% 1.1% 5.9% |
|TERMINAL (d) | 2/57 (4%) 1/46 (2%) 6/47 (13%) 2/48 (4%) |1/59 (2%) 0/68 (0%) 1/60 (2%) 3/61 (5%) |
|FIRST INCIDENCE | 659 581 736 (T) 662 |674 --- 737 (T) 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.558N P=0.597 P=0.168 P=0.601 |P=0.043 * P=0.103N P=0.297N P=0.390 |
|POLY 3 | P=0.548N P=0.640 P=0.234 P=0.636 |P=0.038 * P=0.114N P=0.300N P=0.355 |
|POLY 1.5 | P=0.538N P=0.649 P=0.241 P=0.647 |P=0.038 * P=0.117N P=0.303N P=0.349 |
|POLY 6 | P=0.557N P=0.631 P=0.228 P=0.627 |P=0.038 * P=0.110N P=0.295N P=0.369 |
|LOGISTIC REGRESSION| P=0.549N P=0.655 P=0.231 P=0.634 |P=0.042 * P=0.114N P=0.294N P=0.376 |
|COCH-ARM / FISHERS | P=0.522N P=0.654N P=0.254 P=0.654N |P=0.043 * P=0.123N P=0.311N P=0.360 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |1/100 (1%) 3/100 (3%) 0/100 (0%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 0.0% |1.2% 3.3% 0.0% 1.2% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- --- |553 590 --- 673 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.607N P=0.457 (e) (e) |P=0.466N P=0.333 P=0.498N P=0.760 |
|POLY 3 | P=0.607N P=0.490 (e) (e) |P=0.460N P=0.324 P=0.497N P=0.758 |
|POLY 1.5 | P=0.603N P=0.495 (e) (e) |P=0.463N P=0.317 P=0.499N P=0.756 |
|POLY 6 | P=0.611N P=0.486 (e) (e) |P=0.453N P=0.335 P=0.494N P=0.757N |
|LOGISTIC REGRESSION| (e) P=0.457 (e) (e) |P=0.355N P=0.227 P=0.445N P=0.729N |
|COCH-ARM / FISHERS | P=0.597N P=0.503 (e) (e) |P=0.458N P=0.311 P=0.500N P=0.751N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |2/100 (2%) 0/100 (0%) 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 0.0% 1.2% 0.0% |2.3% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 2/60 (3%) 0/61 (0%) |
|FIRST INCIDENCE | 647 --- 736 (T) --- |655 --- 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.509N P=0.523N P=0.733 P=0.515N |P=0.320N P=0.215N P=0.684N P=0.232N |
|POLY 3 | P=0.500N P=0.511N P=0.755 P=0.511N |P=0.327N P=0.229N P=0.686N P=0.240N |
|POLY 1.5 | P=0.499N P=0.506N P=0.758 P=0.506N |P=0.325N P=0.233N P=0.689N P=0.243N |
|POLY 6 | P=0.501N P=0.516N P=0.752 P=0.516N |P=0.326N P=0.224N P=0.681N P=0.235N |
|LOGISTIC REGRESSION| P=0.501N P=0.479N P=0.760N P=0.479N |P=0.318N P=0.239N P=0.683N P=0.241N |
|COCH-ARM / FISHERS | P=0.498N P=0.497N P=0.749N P=0.497N |P=0.312N P=0.249N P=0.689N P=0.249N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/100 (1%) 2/100 (2%) 4/100 (4%) |0/100 (0%) 1/100 (1%) 1/100 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 2.4% 4.8% |0.0% 1.1% 1.1% 2.3% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | --- 680 568 442 |--- 669 737 (T) 676 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.036 * P=0.494 P=0.238 P=0.060 |P=0.234 P=0.523 P=0.503 P=0.258 |
|POLY 3 | P=0.037 * P=0.491 P=0.235 P=0.059 |P=0.228 P=0.510 P=0.505 P=0.238 |
|POLY 1.5 | P=0.038 * P=0.495 P=0.237 P=0.061 |P=0.226 P=0.505 P=0.502 P=0.235 |
|POLY 6 | P=0.036 * P=0.487 P=0.234 P=0.057 |P=0.234 P=0.515 P=0.508 P=0.246 |
|LOGISTIC REGRESSION| P=0.046 * P=0.504 P=0.254 P=0.089 |P=0.233 P=0.483 P=0.503 P=0.240 |
|COCH-ARM / FISHERS | P=0.040 * P=0.503 P=0.251 P=0.062 |P=0.232 P=0.500 P=0.500 P=0.249 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/99 (20%) 24/100 (24%) 23/100 (23%) 25/100 (25%)|29/100 (29%) 30/100 (30%) 26/100 (26%) 34/100 (34%) |
|POLY-3 ADJUSTED (b)| 22.7% 28.6% 27.1% 30.3% |33.0% 32.5% 29.0% 39.2% |
|TERMINAL (d) | 13/57 (23%) 11/46 (24%) 15/47 (32%) 15/48 (31%) |19/59 (32%) 19/68 (28%) 17/60 (28%) 27/61 (44%) |
|FIRST INCIDENCE | 303 533 621 662 |613 563 501 545 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.257 P=0.152 P=0.200 P=0.130 |P=0.184 P=0.408N P=0.334N P=0.339 |
|POLY 3 | P=0.247 P=0.239 P=0.309 P=0.169 |P=0.143 P=0.532N P=0.336N P=0.241 |
|POLY 1.5 | P=0.278 P=0.265 P=0.334 P=0.201 |P=0.151 P=0.554 P=0.355N P=0.233 |
|POLY 6 | P=0.223 P=0.220 P=0.287 P=0.145 |P=0.145 P=0.481N P=0.313N P=0.268 |
|LOGISTIC REGRESSION| P=0.264 P=0.270 P=0.336 P=0.186 |P=0.161 P=0.562N P=0.338N P=0.273 |
|COCH-ARM / FISHERS | P=0.329 P=0.318 P=0.380 P=0.261 |P=0.205 P=0.500 P=0.376N P=0.271 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/98 (17%) 16/93 (17%) 11/100 (11%) 18/100 (18%)|6/96 (6%) 6/94 (6%) 4/94 (4%) 7/98 (7%) |
|POLY-3 ADJUSTED (b)| 19.6% 20.8% 13.0% 21.6% |7.2% 7.1% 4.9% 8.4% |
|TERMINAL (d) | 10/57 (18%) 5/43 (12%) 3/47 (6%) 8/48 (17%) |1/56 (2%) 5/63 (8%) 2/56 (4%) 5/60 (8%) |
|FIRST INCIDENCE | 614 624 621 461 |610 631 685 701 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.310 P=0.439 P=0.247N P=0.354 |P=0.411 P=0.544N P=0.350N P=0.547 |
|POLY 3 | P=0.363 P=0.507 P=0.166N P=0.452 |P=0.400 P=0.612N P=0.382N P=0.502 |
|POLY 1.5 | P=0.378 P=0.536 P=0.155N P=0.481 |P=0.399 P=0.614 P=0.385N P=0.497 |
|POLY 6 | P=0.351 P=0.482 P=0.177N P=0.427 |P=0.410 P=0.602N P=0.377N P=0.518 |
|LOGISTIC REGRESSION| P=0.362 P=0.519 P=0.159N P=0.472 |P=0.406 P=0.600 P=0.386N P=0.508 |
|COCH-ARM / FISHERS | P=0.398 P=0.566N P=0.141N P=0.526 |P=0.424 P=0.602 P=0.387N P=0.516 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 1/93 (1%) 0/100 (0%) 2/100 (2%) |0/96 (0%) 1/94 (1%) 0/94 (0%) 1/98 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.3% 0.0% 2.4% |0.0% 1.2% 0.0% 1.2% |
|TERMINAL (d) | 0/57 (0%) 0/43 (0%) 0/47 (0%) 1/48 (2%) |0/56 (0%) 0/63 (0%) 0/56 (0%) 1/60 (2%) |
|FIRST INCIDENCE | --- 544 --- 505 |--- 589 --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.153 P=0.489 (e) P=0.214 |P=0.493 P=0.504 (e) P=0.514 |
|POLY 3 | P=0.163 P=0.477 (e) P=0.231 |P=0.505 P=0.505 (e) P=0.503 |
|POLY 1.5 | P=0.166 P=0.482 (e) P=0.235 |P=0.503 P=0.501 (e) P=0.501 |
|POLY 6 | P=0.160 P=0.473 (e) P=0.227 |P=0.512 P=0.511 (e) P=0.510 |
|LOGISTIC REGRESSION| P=0.179 P=0.563 (e) P=0.274 |P=0.534 P=0.437 (e) P=0.514 |
|COCH-ARM / FISHERS | P=0.171 P=0.487 (e) P=0.254 |P=0.507 P=0.495 (e) P=0.505 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone Marrow |
| Depletion Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 2/100 (2%) 3/100 (3%) 2/99 (2%) |9/100 (9%) 5/100 (5%) 6/100 (6%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 3.5% 2.4% 3.5% 2.4% |10.2% 5.5% 6.7% 4.6% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 0/68 (0%) 3/60 (5%) 0/61 (0%) |
|FIRST INCIDENCE | 583 267 405 516 |494 582 429 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.524N P=0.537N P=0.631 P=0.547N |P=0.230N P=0.174N P=0.280N P=0.132N |
|POLY 3 | P=0.517N P=0.519N P=0.656 P=0.524N |P=0.224N P=0.182N P=0.286N P=0.126N |
|POLY 1.5 | P=0.512N P=0.511N P=0.658 P=0.516N |P=0.222N P=0.191N P=0.291N P=0.130N |
|POLY 6 | P=0.519N P=0.529N P=0.654 P=0.532N |P=0.220N P=0.170N P=0.280N P=0.118N |
|LOGISTIC REGRESSION| P=0.528N P=0.370N P=0.625N P=0.455N |P=0.046N* P=0.300N P=0.299N P=0.045N* |
|COCH-ARM / FISHERS | P=0.505N P=0.500N P=0.659N P=0.505N |P=0.206N P=0.203N P=0.296N P=0.125N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 2/99 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- 736 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.039 * (e) (e) P=0.202 |(e) (e) (e) (e) |
|POLY 3 | P=0.040 * (e) (e) P=0.226 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.041 * (e) (e) P=0.230 |(e) (e) (e) (e) |
|POLY 6 | P=0.040 * (e) (e) P=0.222 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.202 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.042 * (e) (e) P=0.246 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/100 (14%) 18/100 (18%) 15/100 (15%) 12/99 (12%) |13/100 (13%) 19/100 (19%) 13/100 (13%) 12/100 (12%) |
|POLY-3 ADJUSTED (b)| 16.0% 20.9% 17.0% 14.0% |14.8% 20.5% 14.5% 13.6% |
|TERMINAL (d) | 6/57 (11%) 9/46 (20%) 4/47 (9%) 2/48 (4%) |7/59 (12%) 9/68 (13%) 5/60 (8%) 6/61 (10%) |
|FIRST INCIDENCE | 502 396 477 442 |462 522 508 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.276N P=0.174 P=0.407 P=0.520N |P=0.268N P=0.271 P=0.544N P=0.481N |
|POLY 3 | P=0.232N P=0.258 P=0.507 P=0.443N |P=0.253N P=0.205 P=0.562N P=0.500N |
|POLY 1.5 | P=0.228N P=0.266 P=0.503 P=0.436N |P=0.257N P=0.188 P=0.574N P=0.513N |
|POLY 6 | P=0.234N P=0.248 P=0.517 P=0.448N |P=0.241N P=0.233 P=0.543N P=0.474N |
|LOGISTIC REGRESSION| P=0.199N P=0.315 P=0.532 P=0.356N |P=0.165N P=0.127 P=0.570 P=0.443N |
|COCH-ARM / FISHERS | P=0.226N P=0.282 P=0.500 P=0.428N |P=0.234N P=0.167 P=0.583N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone Marrow |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 4/100 (4%) 0/99 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.7% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- 568 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.520N (e) P=0.061 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.513N (e) P=0.062 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.508N (e) P=0.063 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.516N (e) P=0.063 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.498N (e) P=0.071 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.502N (e) P=0.061 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone: Cranium |
| Hyperostosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/100 (1%) 1/100 (1%) 0/100 (0%) |7/100 (7%) 1/100 (1%) 5/100 (5%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 1.2% 0.0% |8.2% 1.1% 5.7% 5.9% |
|TERMINAL (d) | 1/57 (2%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |6/59 (10%) 1/68 (2%) 5/60 (8%) 5/61 (8%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 645 --- |617 737 (T) 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.349N P=0.713 P=0.733 P=0.534N |P=0.431 P=0.023N* P=0.366N P=0.360N |
|POLY 3 | P=0.345N P=0.749 P=0.756 P=0.511N |P=0.423 P=0.030N* P=0.370N P=0.390N |
|POLY 1.5 | P=0.342N P=0.753 P=0.757 P=0.507N |P=0.426 P=0.032N* P=0.377N P=0.397N |
|POLY 6 | P=0.348N P=0.744 P=0.755 P=0.515N |P=0.427 P=0.027N* P=0.361N P=0.372N |
|LOGISTIC REGRESSION| P=0.343N P=0.713 P=0.761 (e) |P=0.458 P=0.028N* P=0.350N P=0.355N |
|COCH-ARM / FISHERS | P=0.337N P=0.751N P=0.751N P=0.500N |P=0.455 P=0.032N* P=0.384N P=0.384N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone: Femur |
| Hyperostosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/100 (2%) 5/100 (5%) 2/100 (2%) |20/100 (20%) 10/100 (10%) 20/100 (20%) 18/100 (18%) |
|POLY-3 ADJUSTED (b)| 1.2% 2.4% 5.9% 2.5% |23.0% 11.1% 22.6% 21.1% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 1/48 (2%) |13/59 (22%) 8/68 (12%) 15/60 (25%) 14/61 (23%) |
|FIRST INCIDENCE | 649 612 645 733 |591 631 617 667 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.598 P=0.472 P=0.100 P=0.454 |P=0.323 P=0.018N* P=0.529N P=0.382N |
|POLY 3 | P=0.597 P=0.483 P=0.101 P=0.479 |P=0.290 P=0.027N* P=0.547N P=0.453N |
|POLY 1.5 | P=0.608 P=0.489 P=0.103 P=0.487 |P=0.296 P=0.031N* P=0.560N P=0.462N |
|POLY 6 | P=0.588 P=0.477 P=0.100 P=0.472 |P=0.299 P=0.023N* P=0.531N P=0.427N |
|LOGISTIC REGRESSION| P=0.620 P=0.528 P=0.108 P=0.482 |P=0.320 P=0.026N* P=0.529N P=0.408N |
|COCH-ARM / FISHERS | P=0.622N P=0.500 P=0.106 P=0.500 |P=0.351 P=0.037N* P=0.570N P=0.429N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Bone: Turbinate |
| Hyperostosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |7/100 (7%) 3/100 (3%) 9/100 (9%) 11/100 (11%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 0.0% |8.1% 3.4% 10.3% 12.9% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |4/59 (7%) 3/68 (4%) 8/60 (13%) 8/61 (13%) |
|FIRST INCIDENCE | --- 711 --- --- |591 737 (T) 647 690 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.605N P=0.500 (e) (e) |P=0.053 P=0.124N P=0.417 P=0.258 |
|POLY 3 | P=0.607N P=0.490 (e) (e) |P=0.048 * P=0.149N P=0.411 P=0.220 |
|POLY 1.5 | P=0.603N P=0.494 (e) (e) |P=0.048 * P=0.156N P=0.404 P=0.214 |
|POLY 6 | P=0.610N P=0.486 (e) (e) |P=0.051 P=0.141N P=0.422 P=0.236 |
|LOGISTIC REGRESSION| P=0.604N P=0.488 (e) (e) |P=0.054 P=0.144N P=0.424 P=0.239 |
|COCH-ARM / FISHERS | P=0.597N P=0.500 (e) (e) |P=0.059 P=0.166N P=0.398 P=0.230 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Brain: Cerebrum |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 2/100 (2%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 737 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.374N P=0.271 (e) (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.362N P=0.249 (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.366N P=0.244 (e) (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.355N P=0.255 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) P=0.271 (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.367N P=0.249 (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Brain: Hypothalamus |
| Compression |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 8/100 (8%) 1/100 (1%) 9/100 (9%) |16/100 (16%) 9/100 (9%) 16/100 (16%) 15/100 (15%) |
|POLY-3 ADJUSTED (b)| 5.8% 9.7% 1.2% 10.8% |18.2% 9.9% 17.7% 17.3% |
|TERMINAL (d) | 1/57 (2%) 2/46 (4%) 1/47 (2%) 2/48 (4%) |8/59 (14%) 3/68 (4%) 5/60 (8%) 9/61 (15%) |
|FIRST INCIDENCE | 583 613 736 (T) 516 |543 563 556 522 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.144 P=0.215 P=0.130N P=0.161 |P=0.345 P=0.068N P=0.533N P=0.473N |
|POLY 3 | P=0.147 P=0.250 P=0.115N P=0.177 |P=0.314 P=0.082N P=0.546N P=0.520N |
|POLY 1.5 | P=0.152 P=0.262 P=0.111N P=0.187 |P=0.318 P=0.089N P=0.562N P=0.528N |
|POLY 6 | P=0.145 P=0.238 P=0.119N P=0.170 |P=0.321 P=0.074N P=0.523N P=0.497N |
|LOGISTIC REGRESSION| P=0.162 P=0.282 P=0.104N P=0.225 |P=0.388 P=0.119N P=0.565 P=0.507N |
|COCH-ARM / FISHERS | P=0.160 P=0.284 P=0.106N P=0.203 |P=0.365 P=0.099N P=0.576N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |1/90 (1%) 0/96 (0%) 7/97 (7%) 1/96 (1%) |
|POLY-3 ADJUSTED (b)| |1.3% 0.0% 8.3% 1.2% |
|TERMINAL (d) | |1/56 (2%) 0/65 (0%) 6/58 (10%) 1/59 (2%) |
|FIRST INCIDENCE | |737 (T) --- 639 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.539N P=0.470N P=0.040 * P=0.750N |
|POLY 3 | |P=0.541N P=0.479N P=0.046 * P=0.748N |
|POLY 1.5 | |P=0.542N P=0.482N P=0.045 * P=0.750N |
|POLY 6 | |P=0.531N P=0.474N P=0.048 * P=0.742N |
|LOGISTIC REGRESSION| |P=0.522N (e) P=0.048 * P=0.750N |
|COCH-ARM / FISHERS | |P=0.518N P=0.484N P=0.041 * P=0.735N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |6/90 (7%) 4/96 (4%) 3/97 (3%) 5/96 (5%) |
|POLY-3 ADJUSTED (b)| |7.8% 4.7% 3.5% 6.1% |
|TERMINAL (d) | |5/56 (9%) 3/65 (5%) 1/58 (2%) 5/59 (9%) |
|FIRST INCIDENCE | |673 727 610 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.536 P=0.290N P=0.226N P=0.464N |
|POLY 3 | |P=0.541 P=0.310N P=0.201N P=0.462N |
|POLY 1.5 | |P=0.542 P=0.320N P=0.206N P=0.470N |
|POLY 6 | |P=0.548 P=0.298N P=0.193N P=0.446N |
|LOGISTIC REGRESSION| |P=0.556 P=0.286N P=0.205N P=0.424N |
|COCH-ARM / FISHERS | |P=0.565 P=0.334N P=0.213N P=0.455N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |25/90 (28%) 20/96 (21%) 19/97 (20%) 30/96 (31%) |
|POLY-3 ADJUSTED (b)| |32.1% 23.0% 22.0% 36.1% |
|TERMINAL (d) | |21/56 (38%) 14/65 (22%) 14/58 (24%) 24/59 (41%) |
|FIRST INCIDENCE | |591 522 358 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.060 P=0.116N P=0.159N P=0.337 |
|POLY 3 | |P=0.060 P=0.126N P=0.097N P=0.355 |
|POLY 1.5 | |P=0.061 P=0.145N P=0.109N P=0.335 |
|POLY 6 | |P=0.064 P=0.104N P=0.086N P=0.399 |
|LOGISTIC REGRESSION| |P=0.064 P=0.117N P=0.105N P=0.379 |
|COCH-ARM / FISHERS | |P=0.085 P=0.175N P=0.126N P=0.361 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/100 (0%) 0/100 (0%) 3/100 (3%) | |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 0.0% 3.7% | |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 1/48 (2%) | |
|FIRST INCIDENCE | 641 --- --- 703 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.109 P=0.279N P=0.268N P=0.448 | |
|POLY 3 | P=0.113 P=0.251N P=0.245N P=0.474 | |
|POLY 1.5 | P=0.114 P=0.246N P=0.242N P=0.484 | |
|POLY 6 | P=0.112 P=0.256N P=0.247N P=0.465 | |
|LOGISTIC REGRESSION| P=0.107 P=0.240N P=0.239N P=0.473 | |
|COCH-ARM / FISHERS | P=0.115 P=0.249N P=0.249N P=0.500 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 6/100 (6%) 5/100 (5%) 6/100 (6%) | |
|POLY-3 ADJUSTED (b)| 2.3% 7.2% 5.9% 7.3% | |
|TERMINAL (d) | 1/57 (2%) 2/46 (4%) 2/47 (4%) 4/48 (8%) | |
|FIRST INCIDENCE | 617 396 652 461 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.275 P=0.109 P=0.189 P=0.102 | |
|POLY 3 | P=0.280 P=0.126 P=0.211 P=0.124 | |
|POLY 1.5 | P=0.289 P=0.131 P=0.214 P=0.130 | |
|POLY 6 | P=0.272 P=0.121 P=0.208 P=0.119 | |
|LOGISTIC REGRESSION| P=0.309 P=0.156 P=0.216 P=0.149 | |
|COCH-ARM / FISHERS | P=0.303 P=0.140 P=0.222 P=0.140 | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Epididymis: Epithelium |
| Degeneration Mucoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 82/100 (82%) 76/100 (76%) 83/100 (83%) 72/100 (72%)| |
|POLY-3 ADJUSTED (b)| 87.1% 86.1% 89.9% 80.5% | |
|TERMINAL (d) | 49/57 (86%) 43/46 (94%) 44/47 (94%) 41/48 (85%) | |
|FIRST INCIDENCE | 527 589 496 442 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.329N P=0.258 P=0.133 P=0.538 | |
|POLY 3 | P=0.061N P=0.504N P=0.347 P=0.132N | |
|POLY 1.5 | P=0.059N P=0.347N P=0.416 P=0.091N | |
|POLY 6 | P=0.072N P=0.504 P=0.282 P=0.203N | |
|LOGISTIC REGRESSION| P=0.169N P=0.492N P=0.293 P=0.196N | |
|COCH-ARM / FISHERS | P=0.075N P=0.193N P=0.500 P=0.065N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Eye |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/3 (0%) 0/2 (0%) 0/7 (0%) |0/6 (0%) 0/4 (0%) 2/7 (29%) 1/6 (17%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 29.2% 19.3% |
|TERMINAL (d) | 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/4 (0%) |0/3 (0%) 0/4 (0%) 1/5 (20%) 1/5 (20%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- 652 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.507 (e) P=0.305 P=0.602 |
|POLY 3 | (e) (e) (e) (e) |P=0.472 (e) P=0.309 P=0.515 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.469 (e) P=0.285 P=0.504 |
|POLY 6 | (e) (e) (e) (e) |P=0.490 (e) P=0.342 P=0.537 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.473 (e) P=0.225 P=0.602 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.480 (e) P=0.269 P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Eye: Iris |
| Synechia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/3 (0%) 0/2 (0%) 1/7 (14%) |2/6 (33%) 0/4 (0%) 0/7 (0%) 0/6 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 17.0% |41.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/1 (0%) 0/0 (0%) 1/4 (25%) |2/3 (67%) 0/4 (0%) 0/5 (0%) 0/5 (0%) |
|FIRST INCIDENCE | --- --- --- 736 (T) |737 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.692 (e) (e) P=1.000N |P=0.299N P=0.157N P=0.118N P=0.118N |
|POLY 3 | P=1.000N (e) (e) P=1.000N |P=0.371N P=0.246N P=0.137N P=0.186N |
|POLY 1.5 | P=1.000N (e) (e) P=1.000N |P=0.350N P=0.278N P=0.154N P=0.203N |
|POLY 6 | P=1.000N (e) (e) P=1.000N |P=0.399N P=0.203N P=0.116N P=0.156N |
|LOGISTIC REGRESSION| (e) (e) (e) P=1.000N |P=0.299N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.516 (e) (e) P=1.000 |P=0.330N P=0.333N P=0.192N P=0.227N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Eye: Lens |
| Cataract |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 3/3 (100%) 1/2 (50%) 6/7 (86%) |6/6 (100%) 4/4 (100%) 5/7 (71%) 4/6 (67%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 69.3% 96.4% |100.0% 100.0% 74.7% 77.4% |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 4/4 (100%) |3/3 (100%) 4/4 (100%) 4/5 (80%) 4/5 (80%) |
|FIRST INCIDENCE | --- 652 539 668 |543 737 (T) 696 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.356 (e) P=0.491 P=0.214 |P=0.140N (e) P=0.203N P=0.079N |
|POLY 3 | P=1.000 (e) P=1.000N P=1.000N |P=0.321N (e) P=0.300N P=0.397N |
|POLY 1.5 | P=1.000 (e) P=1.000N P=1.000N |P=0.265N (e) P=0.277N P=0.317N |
|POLY 6 | P=1.000 (e) P=1.000N P=1.000N |P=0.352N (e) P=0.345N P=0.452N |
|LOGISTIC REGRESSION| P=0.976N (e) (e) (e) |P=0.237N (e) P=0.225N P=0.221N |
|COCH-ARM / FISHERS | P=0.732 (e) P=1.000 P=1.000 |P=0.171N (e) P=0.269N P=0.227N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 3/3 (100%) 2/2 (100%) 7/7 (100%) |6/6 (100%) 4/4 (100%) 5/7 (71%) 4/6 (67%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% |100.0% 100.0% 74.7% 77.4% |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 4/4 (100%) |3/3 (100%) 4/4 (100%) 4/5 (80%) 4/5 (80%) |
|FIRST INCIDENCE | --- 652 539 445 |543 737 (T) 696 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.140N (e) P=0.203N P=0.079N |
|POLY 3 | (e) (e) (e) (e) |P=0.321N (e) P=0.300N P=0.397N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.265N (e) P=0.277N P=0.317N |
|POLY 6 | (e) (e) (e) (e) |P=0.352N (e) P=0.345N P=0.452N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.237N (e) P=0.225N P=0.221N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.171N (e) P=0.269N P=0.227N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Atrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 1/100 (1%) 8/100 (8%) 2/100 (2%) |1/100 (1%) 2/100 (2%) 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 2.3% 1.2% 9.5% 2.5% |1.2% 2.2% 2.3% 3.5% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 3/47 (6%) 0/48 (0%) |1/59 (2%) 1/68 (2%) 2/60 (3%) 3/61 (5%) |
|FIRST INCIDENCE | 661 729 649 683 |737 (T) 682 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.547N P=0.549N P=0.041 * P=0.661 |P=0.290 P=0.545 P=0.506 P=0.318 |
|POLY 3 | P=0.548N P=0.519N P=0.047 * P=0.672 |P=0.291 P=0.517 P=0.508 P=0.305 |
|POLY 1.5 | P=0.539N P=0.512N P=0.049 * P=0.680 |P=0.289 P=0.509 P=0.504 P=0.301 |
|POLY 6 | P=0.553N P=0.527N P=0.046 * P=0.666 |P=0.297 P=0.527 P=0.514 P=0.315 |
|LOGISTIC REGRESSION| P=0.547N P=0.519N P=0.048 * P=0.679 |P=0.303 P=0.521 P=0.506 P=0.318 |
|COCH-ARM / FISHERS | P=0.526N P=0.500N P=0.050 P=0.689N |P=0.301 P=0.500 P=0.500 P=0.311 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/100 (2%) 4/100 (4%) 0/100 (0%) |0/100 (0%) 1/100 (1%) 0/100 (0%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 2.5% 4.8% 0.0% |0.0% 1.1% 0.0% 2.4% |
|TERMINAL (d) | 2/57 (4%) 1/46 (2%) 3/47 (6%) 0/48 (0%) |0/59 (0%) 1/68 (2%) 0/60 (0%) 2/61 (3%) |
|FIRST INCIDENCE | 736 (T) 720 726 --- |--- 737 (T) --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.161N P=0.624 P=0.266 P=0.277N |P=0.156 P=0.528 (e) P=0.246 |
|POLY 3 | P=0.159N P=0.674 P=0.328 P=0.251N |P=0.159 P=0.509 (e) P=0.237 |
|POLY 1.5 | P=0.155N P=0.681 P=0.332 P=0.246N |P=0.158 P=0.505 (e) P=0.235 |
|POLY 6 | P=0.162N P=0.668 P=0.325 P=0.255N |P=0.163 P=0.514 (e) P=0.243 |
|LOGISTIC REGRESSION| P=0.155N P=0.660 P=0.313 (e) |(e) P=0.528 (e) P=0.246 |
|COCH-ARM / FISHERS | P=0.149N P=0.689N P=0.341 P=0.249N |P=0.162 P=0.500 (e) P=0.249 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/100 (43%) 49/100 (49%) 44/100 (44%) 46/100 (46%)|69/100 (69%) 73/100 (73%) 65/100 (65%) 56/100 (56%) |
|POLY-3 ADJUSTED (b)| 48.0% 56.2% 51.5% 53.3% |72.5% 75.2% 68.5% 60.6% |
|TERMINAL (d) | 29/57 (51%) 29/46 (63%) 33/47 (70%) 32/48 (67%) |38/59 (64%) 48/68 (71%) 42/60 (70%) 35/61 (57%) |
|FIRST INCIDENCE | 573 267 635 442 |494 498 358 394 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.369 P=0.052 P=0.180 P=0.127 |P=0.051N P=0.363N P=0.291N P=0.062N |
|POLY 3 | P=0.450 P=0.163 P=0.370 P=0.281 |P=0.015N* P=0.392 P=0.324N P=0.053N |
|POLY 1.5 | P=0.482 P=0.195 P=0.425 P=0.327 |P=0.015N* P=0.362 P=0.322N P=0.055N |
|POLY 6 | P=0.412 P=0.129 P=0.310 P=0.231 |P=0.014N* P=0.426 P=0.341N P=0.050N |
|LOGISTIC REGRESSION| P=0.417 P=0.158 P=0.414 P=0.268 |P=0.011N* P=0.337 P=0.318N P=0.047N* |
|COCH-ARM / FISHERS | P=0.519 P=0.239 P=0.500 P=0.388 |P=0.008N** P=0.320 P=0.326N P=0.040N* |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/100 (10%) 12/100 (12%) 11/100 (11%) 5/100 (5%) |10/100 (10%) 9/100 (9%) 16/100 (16%) 15/100 (15%) |
|POLY-3 ADJUSTED (b)| 11.4% 14.5% 13.0% 6.1% |11.6% 10.0% 18.2% 17.4% |
|TERMINAL (d) | 4/57 (7%) 8/46 (17%) 6/47 (13%) 2/48 (4%) |7/59 (12%) 8/68 (12%) 13/60 (22%) 12/61 (20%) |
|FIRST INCIDENCE | 527 490 535 592 |591 582 617 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.079N P=0.282 P=0.401 P=0.207N |P=0.131 P=0.388N P=0.163 P=0.219 |
|POLY 3 | P=0.070N P=0.357 P=0.463 P=0.172N |P=0.133 P=0.465N P=0.153 P=0.192 |
|POLY 1.5 | P=0.065N P=0.377 P=0.478 P=0.159N |P=0.131 P=0.480N P=0.149 P=0.184 |
|POLY 6 | P=0.075N P=0.335 P=0.446 P=0.184N |P=0.142 P=0.446N P=0.158 P=0.209 |
|LOGISTIC REGRESSION| P=0.062N P=0.401 P=0.488 P=0.138N |P=0.132 P=0.463N P=0.168 P=0.188 |
|COCH-ARM / FISHERS | P=0.058N P=0.411 P=0.500 P=0.141N |P=0.153 P=0.500N P=0.147 P=0.196 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 88/100 (88%) 87/100 (87%) 88/100 (88%) 87/100 (87%)|53/100 (53%) 71/100 (71%) 64/100 (64%) 61/100 (61%) |
|POLY-3 ADJUSTED (b)| 92.0% 92.9% 93.7% 92.0% |59.8% 75.8% 70.5% 67.8% |
|TERMINAL (d) | 55/57 (97%) 46/46 (100%) 46/47 (98%) 48/48 (100%)|39/59 (66%) 55/68 (81%) 43/60 (72%) 42/61 (69%) |
|FIRST INCIDENCE | 476 329 393 410 |591 508 639 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.334 P=0.091 P=0.131 P=0.137 |P=0.530 P=0.109 P=0.143 P=0.262 |
|POLY 3 | P=0.507N P=0.523 P=0.425 P=0.616 |P=0.493N P=0.011 * P=0.078 P=0.160 |
|POLY 1.5 | P=0.478N P=0.585 P=0.507 P=0.551N |P=0.533N P=0.008 ** P=0.072 P=0.131 |
|POLY 6 | P=0.594N P=0.457 P=0.337 P=0.538 |P=0.389N P=0.017 * P=0.100 P=0.241 |
|LOGISTIC REGRESSION| P=0.445 P=0.424 P=0.409 P=0.454 |P=0.507 P=0.017 * P=0.117 P=0.131 |
|COCH-ARM / FISHERS | P=0.500N P=0.500N P=0.586N P=0.500N |P=0.452N P=0.007 ** P=0.076 P=0.159 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 6/100 (6%) 6/100 (6%) 9/100 (9%) |1/100 (1%) 0/100 (0%) 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 6.9% 7.3% 7.1% 10.8% |1.2% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 2/57 (4%) 1/46 (2%) 0/47 (0%) 3/48 (6%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 658 581 496 481 |729 --- 694 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.186 P=0.536 P=0.576 P=0.238 |P=0.437N P=0.475N P=0.517 P=0.484N |
|POLY 3 | P=0.195 P=0.585 P=0.604 P=0.269 |P=0.457N P=0.491N P=0.509 P=0.501N |
|POLY 1.5 | P=0.200 P=0.597 P=0.609 P=0.280 |P=0.456N P=0.495N P=0.504 P=0.504N |
|POLY 6 | P=0.192 P=0.574 P=0.601 P=0.261 |P=0.454N P=0.486N P=0.515 P=0.496N |
|LOGISTIC REGRESSION| P=0.218 P=0.616N P=0.609N P=0.326 |P=0.450N P=0.481N P=0.510 P=0.490N |
|COCH-ARM / FISHERS | P=0.206 P=0.616N P=0.616N P=0.296 |P=0.443N P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Heart: Valve |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 2.5% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- 668 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.152 P=0.457 (e) P=0.214 |(e) (e) (e) (e) |
|POLY 3 | P=0.155 P=0.490 (e) P=0.227 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.157 P=0.493 (e) P=0.231 |(e) (e) (e) (e) |
|POLY 6 | P=0.152 P=0.486 (e) P=0.223 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.154 P=0.457 (e) P=0.228 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.162 P=0.500 (e) P=0.249 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Intestine Small, Ileum: Peyer's Patch |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/94 (0%) 0/92 (0%) 0/97 (0%) 2/96 (2%) |0/94 (0%) 0/91 (0%) 0/93 (0%) 2/97 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% |0.0% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 2/61 (3%) |
|FIRST INCIDENCE | --- --- --- 488 |--- --- --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.040 * (e) (e) P=0.216 |P=0.041 * (e) (e) P=0.246 |
|POLY 3 | P=0.042 * (e) (e) P=0.228 |P=0.045 * (e) (e) P=0.244 |
|POLY 1.5 | P=0.043 * (e) (e) P=0.233 |P=0.045 * (e) (e) P=0.242 |
|POLY 6 | P=0.041 * (e) (e) P=0.223 |P=0.045 * (e) (e) P=0.249 |
|LOGISTIC REGRESSION| P=0.053 (e) (e) P=0.315 |(e) (e) (e) P=0.246 |
|COCH-ARM / FISHERS | P=0.045 * (e) (e) P=0.254 |P=0.047 * (e) (e) P=0.257 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/99 (1%) 9/99 (9%) 2/99 (2%) |0/100 (0%) 1/100 (1%) 0/99 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 10.7% 2.5% |0.0% 1.1% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 4/47 (9%) 1/48 (2%) |0/59 (0%) 1/68 (2%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) 734 635 551 |--- 737 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.605N P=0.714 P=0.007 ** P=0.451 |P=0.603N P=0.528 (e) (e) |
|POLY 3 | P=0.601N P=0.748 P=0.010 * P=0.482 |P=0.593N P=0.509 (e) (e) |
|POLY 1.5 | P=0.593N P=0.753 P=0.010 * P=0.489 |P=0.595N P=0.505 (e) (e) |
|POLY 6 | P=0.606N P=0.743 P=0.009 ** P=0.476 |P=0.589N P=0.514 (e) (e) |
|LOGISTIC REGRESSION| P=0.603N P=0.733 P=0.010 * P=0.508 |(e) P=0.528 (e) (e) |
|COCH-ARM / FISHERS | P=0.580N P=0.751N P=0.009 ** P=0.500 |P=0.597N P=0.500 (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 3/100 (3%) 1/100 (1%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 3.7% 1.2% 2.4% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 2/46 (4%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) 713 724 445 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.593 P=0.249 P=0.741 P=0.472 |(e) (e) (e) (e) |
|POLY 3 | P=0.595 P=0.289 P=0.755 P=0.485 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.600 P=0.295 P=0.757 P=0.490 |(e) (e) (e) (e) |
|POLY 6 | P=0.591 P=0.282 P=0.754 P=0.480 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.608 P=0.274 P=0.755 P=0.543 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.608 P=0.311 P=0.751N P=0.500 |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |3/100 (3%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |3.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |736 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.247N P=0.100N P=0.121N P=0.118N |
|POLY 3 | (e) (e) (e) (e) |P=0.252N P=0.113N P=0.117N P=0.122N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.248N P=0.117N P=0.119N P=0.125N |
|POLY 6 | (e) (e) (e) (e) |P=0.255N P=0.109N P=0.114N P=0.117N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.239N P=0.100N P=0.117N P=0.110N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.240N P=0.123N P=0.123N P=0.123N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 39/100 (39%) 28/100 (28%) 33/100 (33%) 31/100 (31%)|23/100 (23%) 24/100 (24%) 29/100 (29%) 17/100 (17%) |
|POLY-3 ADJUSTED (b)| 43.5% 32.9% 38.5% 37.0% |26.4% 26.6% 32.5% 19.8% |
|TERMINAL (d) | 23/57 (40%) 11/46 (24%) 16/47 (34%) 20/48 (42%) |16/59 (27%) 19/68 (28%) 20/60 (33%) 15/61 (25%) |
|FIRST INCIDENCE | 406 593 496 461 |617 641 501 557 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.477N P=0.253N P=0.454N P=0.368N |P=0.110N P=0.431N P=0.256 P=0.157N |
|POLY 3 | P=0.444N P=0.095N P=0.297N P=0.231N |P=0.111N P=0.555 P=0.232 P=0.198N |
|POLY 1.5 | P=0.409N P=0.085N P=0.268N P=0.195N |P=0.112N P=0.532 P=0.220 P=0.207N |
|POLY 6 | P=0.483N P=0.105N P=0.331N P=0.271N |P=0.101N P=0.555N P=0.249 P=0.179N |
|LOGISTIC REGRESSION| P=0.441N P=0.098N P=0.273N P=0.225N |P=0.099N P=0.530N P=0.245 P=0.178N |
|COCH-ARM / FISHERS | P=0.367N P=0.067N P=0.231N P=0.150N |P=0.089N P=0.500 P=0.210 P=0.188N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 92/100 (92%) 85/100 (85%) 89/100 (89%) 86/100 (86%)|54/100 (54%) 46/100 (46%) 69/100 (69%) 46/100 (46%) |
|POLY-3 ADJUSTED (b)| 94.9% 91.1% 93.9% 93.0% |58.4% 50.8% 73.6% 52.5% |
|TERMINAL (d) | 57/57 (100%) 45/46 (98%) 46/47 (98%) 48/48 (100%)|34/59 (58%) 40/68 (59%) 45/60 (75%) 35/61 (57%) |
|FIRST INCIDENCE | 303 466 463 442 |462 589 429 533 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.440 P=0.253 P=0.212 P=0.296 |P=0.223N P=0.040N* P=0.073 P=0.135N |
|POLY 3 | P=0.567N P=0.198N P=0.507N P=0.387N |P=0.247N P=0.180N P=0.017 * P=0.253N |
|POLY 1.5 | P=0.426N P=0.158N P=0.423N P=0.249N |P=0.236N P=0.170N P=0.017 * P=0.238N |
|POLY 6 | P=0.485 P=0.227N P=0.619N P=0.584N |P=0.226N P=0.200N P=0.020 * P=0.249N |
|LOGISTIC REGRESSION| P=0.476N P=0.192N P=0.418N P=0.318N |P=0.212N P=0.097N P=0.024 * P=0.182N |
|COCH-ARM / FISHERS | P=0.300N P=0.091N P=0.315N P=0.129N |P=0.147N P=0.161N P=0.021 * P=0.161N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 2/100 (2%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.4% 1.2% |0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- 736 (T) 565 |--- --- 557 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.428 (e) P=0.197 P=0.480 |P=0.639N (e) P=0.246 (e) |
|POLY 3 | P=0.434 (e) P=0.233 P=0.490 |P=0.643N (e) P=0.245 (e) |
|POLY 1.5 | P=0.439 (e) P=0.235 P=0.494 |P=0.644N (e) P=0.242 (e) |
|POLY 6 | P=0.432 (e) P=0.231 P=0.487 |P=0.639N (e) P=0.250 (e) |
|LOGISTIC REGRESSION| P=0.446 (e) P=0.197 P=0.531 |P=0.584N (e) P=0.239 (e) |
|COCH-ARM / FISHERS | P=0.445 (e) P=0.249 P=0.500 |P=0.634N (e) P=0.249 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Papilla |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/100 (2%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.4% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 267 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.367N P=0.240 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.377N P=0.232 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.373N P=0.235 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.382N P=0.228 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.998N P=0.333 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.367N P=0.249 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |2/100 (2%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |543 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.372N P=0.230N P=0.236N P=0.243N |
|POLY 3 | (e) (e) (e) (e) |P=0.375N P=0.231N P=0.236N P=0.242N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.372N P=0.234N P=0.237N P=0.244N |
|POLY 6 | (e) (e) (e) (e) |P=0.377N P=0.226N P=0.233N P=0.237N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.253N P=0.302N P=0.213N P=0.177N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.365N P=0.249N P=0.249N P=0.249N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |2/100 (2%) 5/100 (5%) 1/100 (1%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 2.3% 1.2% 0.0% 0.0% |2.3% 5.5% 1.1% 1.2% |
|TERMINAL (d) | 1/57 (2%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 3/68 (4%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 579 736 (T) --- --- |737 (T) 589 703 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.255N P=0.557N P=0.269N P=0.273N |P=0.197N P=0.266 P=0.491N P=0.488N |
|POLY 3 | P=0.242N P=0.520N P=0.245N P=0.252N |P=0.189N P=0.244 P=0.491N P=0.502N |
|POLY 1.5 | P=0.242N P=0.513N P=0.243N P=0.247N |P=0.191N P=0.234 P=0.496N P=0.506N |
|POLY 6 | P=0.242N P=0.528N P=0.248N P=0.258N |P=0.182N P=0.258 P=0.485N P=0.492N |
|LOGISTIC REGRESSION| P=0.241N P=0.500N P=0.231N P=0.225N |P=0.189N P=0.215 P=0.484N P=0.488N |
|COCH-ARM / FISHERS | P=0.241N P=0.500N P=0.249N P=0.249N |P=0.185N P=0.222 P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Pelvis, Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.3% 1.2% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |
|FIRST INCIDENCE | 605 616 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.255N P=0.548N P=0.269N P=0.272N |(e) (e) (e) (e) |
|POLY 3 | P=0.243N P=0.518N P=0.245N P=0.252N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.242N P=0.512N P=0.243N P=0.247N |(e) (e) (e) (e) |
|POLY 6 | P=0.243N P=0.525N P=0.247N P=0.257N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.236N P=0.476N P=0.234N P=0.231N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.241N P=0.500N P=0.249N P=0.249N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |5/100 (5%) 2/100 (2%) 3/100 (3%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |5.8% 2.2% 3.4% 3.5% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |4/59 (7%) 2/68 (3%) 2/60 (3%) 2/61 (3%) |
|FIRST INCIDENCE | --- --- --- --- |691 737 (T) 643 701 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.537N P=0.170N P=0.342N P=0.334N |
|POLY 3 | (e) (e) (e) (e) |P=0.549N P=0.203N P=0.346N P=0.362N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.547N P=0.211N P=0.353N P=0.369N |
|POLY 6 | (e) (e) (e) (e) |P=0.544N P=0.194N P=0.336N P=0.347N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.534N P=0.182N P=0.339N P=0.337N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.527N P=0.222N P=0.360N P=0.360N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/100 (2%) 2/100 (2%) 1/100 (1%) |2/100 (2%) 2/100 (2%) 1/100 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 2.4% 2.4% 1.2% |2.3% 2.2% 1.1% 2.3% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 659 267 621 703 |553 669 619 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.400N P=0.665 P=0.655 P=0.531N |P=0.593 P=0.665N P=0.488N P=0.680 |
|POLY 3 | P=0.408N P=0.681 P=0.684 P=0.520N |P=0.597 P=0.679N P=0.495N P=0.690 |
|POLY 1.5 | P=0.402N P=0.686 P=0.687 P=0.512N |P=0.597 P=0.685N P=0.498N P=0.686 |
|POLY 6 | P=0.413N P=0.675 P=0.683 P=0.527N |P=0.602 P=0.671N P=0.491N P=0.688N |
|LOGISTIC REGRESSION| P=0.374N P=0.554N P=0.693N P=0.513N |P=0.481N P=0.604 P=0.451N P=0.571N |
|COCH-ARM / FISHERS | P=0.391N P=0.689N P=0.689N P=0.500N |P=0.609 P=0.689N P=0.500N P=0.689N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/100 (29%) 20/100 (20%) 26/100 (26%) 23/100 (23%)|26/100 (26%) 11/100 (11%) 13/100 (13%) 30/100 (30%) |
|POLY-3 ADJUSTED (b)| 32.0% 23.1% 29.4% 26.1% |28.8% 12.1% 14.6% 34.3% |
|TERMINAL (d) | 9/57 (16%) 3/46 (7%) 3/47 (6%) 5/48 (10%) |13/59 (22%) 7/68 (10%) 7/60 (12%) 20/61 (33%) |
|FIRST INCIDENCE | 573 466 520 442 |462 498 488 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.492N P=0.229N P=0.487N P=0.370N |P=0.007 ** P=0.003N** P=0.018N* P=0.375 |
|POLY 3 | P=0.413N P=0.123N P=0.418N P=0.242N |P=0.003 ** P=0.004N** P=0.015N* P=0.264 |
|POLY 1.5 | P=0.407N P=0.111N P=0.401N P=0.226N |P=0.004 ** P=0.004N** P=0.015N* P=0.267 |
|POLY 6 | P=0.423N P=0.140N P=0.432N P=0.263N |P=0.003 ** P=0.004N** P=0.015N* P=0.276 |
|LOGISTIC REGRESSION| P=0.381N P=0.081N P=0.370N P=0.156N |P=0.006 ** P=0.008N** P=0.017N* P=0.306 |
|COCH-ARM / FISHERS | P=0.410N P=0.094N P=0.376N P=0.210N |P=0.007 ** P=0.005N** P=0.016N* P=0.318 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) 3/100 (3%) 0/100 (0%) |1/100 (1%) 1/100 (1%) 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 3.6% 0.0% |1.2% 1.1% 2.3% 3.5% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 1/68 (2%) 2/60 (3%) 2/61 (3%) |
|FIRST INCIDENCE | --- 736 (T) 701 --- |561 737 (T) 737 (T) 155 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.420N P=0.457 P=0.101 (e) |P=0.191 P=0.740N P=0.504 P=0.307 |
|POLY 3 | P=0.420N P=0.490 P=0.117 (e) |P=0.196 P=0.752N P=0.506 P=0.307 |
|POLY 1.5 | P=0.414N P=0.493 P=0.119 (e) |P=0.195 P=0.756N P=0.503 P=0.303 |
|POLY 6 | P=0.426N P=0.486 P=0.116 (e) |P=0.200 P=0.747N P=0.510 P=0.316 |
|LOGISTIC REGRESSION| P=0.415N P=0.457 P=0.116 (e) |P=0.306 P=0.731 P=0.497 P=0.457 |
|COCH-ARM / FISHERS | P=0.404N P=0.500 P=0.123 (e) |P=0.203 P=0.751N P=0.500 P=0.311 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 35/100 (35%) 35/100 (35%) 47/100 (47%) 37/100 (37%)|66/100 (66%) 82/100 (82%) 77/100 (77%) 66/100 (66%) |
|POLY-3 ADJUSTED (b)| 40.3% 40.7% 54.4% 44.3% |71.7% 85.0% 82.8% 72.1% |
|TERMINAL (d) | 31/57 (54%) 24/46 (52%) 39/47 (83%) 30/48 (63%) |46/59 (78%) 60/68 (88%) 57/60 (95%) 47/61 (77%) |
|FIRST INCIDENCE | 583 267 477 516 |533 508 429 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.365 P=0.197 P<0.001 ** P=0.139 |P=0.171N P=0.217 P=0.134 P=0.455N |
|POLY 3 | P=0.417 P=0.540 P=0.038 * P=0.348 |P=0.087N P=0.014 * P=0.040 * P=0.544 |
|POLY 1.5 | P=0.457 P=0.547 P=0.045 * P=0.384 |P=0.099N P=0.010 * P=0.044 * P=0.508 |
|POLY 6 | P=0.387 P=0.540 P=0.031 * P=0.323 |P=0.065N P=0.021 * P=0.038 * P=0.532N |
|LOGISTIC REGRESSION| P=0.416 P=0.446 P=0.028 * P=0.272 |P=0.144N P=0.016 * P=0.074 P=0.481 |
|COCH-ARM / FISHERS | P=0.521 P=0.559N P=0.057 P=0.441 |P=0.068N P=0.008 ** P=0.058 P=0.559N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 44/100 (44%) 37/100 (37%) 38/100 (38%) 35/100 (35%)|6/100 (6%) 13/100 (13%) 18/100 (18%) 13/100 (13%) |
|POLY-3 ADJUSTED (b)| 51.0% 44.4% 44.9% 42.9% |7.0% 14.5% 20.3% 15.2% |
|TERMINAL (d) | 41/57 (72%) 32/46 (70%) 35/47 (75%) 33/48 (69%) |6/59 (10%) 12/68 (18%) 15/60 (25%) 11/61 (18%) |
|FIRST INCIDENCE | 647 534 477 614 |737 (T) 669 429 485 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.287N P=0.493 P=0.473 P=0.386N |P=0.290 P=0.125 P=0.009 ** P=0.081 |
|POLY 3 | P=0.273N P=0.234N P=0.253N P=0.178N |P=0.307 P=0.088 P=0.009 ** P=0.072 |
|POLY 1.5 | P=0.245N P=0.221N P=0.246N P=0.154N |P=0.299 P=0.081 P=0.008 ** P=0.068 |
|POLY 6 | P=0.300N P=0.241N P=0.254N P=0.200N |P=0.333 P=0.098 P=0.011 * P=0.083 |
|LOGISTIC REGRESSION| P=0.263N P=0.331N P=0.246N P=0.179N |P=0.304 P=0.111 P=0.010 * P=0.077 |
|COCH-ARM / FISHERS | P=0.212N P=0.194N P=0.236N P=0.124N |P=0.330 P=0.073 P=0.008 ** P=0.073 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Degeneration Cystic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 2/100 (2%) 11/100 (11%) 13/100 (13%)|0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 9.2% 2.5% 13.1% 15.9% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 5/57 (9%) 1/46 (2%) 8/47 (17%) 10/48 (21%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 579 733 715 647 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.016 * P=0.089N P=0.209 P=0.103 |(e) (e) (e) (e) |
|POLY 3 | P=0.018 * P=0.062N P=0.286 P=0.141 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.020 * P=0.058N P=0.298 P=0.155 |(e) (e) (e) (e) |
|POLY 6 | P=0.018 * P=0.067N P=0.275 P=0.131 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.016 * P=0.063N P=0.288 P=0.137 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.023 * P=0.050N P=0.315 P=0.178 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/100 (21%) 19/100 (19%) 26/100 (26%) 17/100 (17%)|18/100 (18%) 24/100 (24%) 30/100 (30%) 24/100 (24%) |
|POLY-3 ADJUSTED (b)| 24.3% 23.2% 30.8% 20.9% |20.6% 26.5% 34.0% 27.7% |
|TERMINAL (d) | 17/57 (30%) 15/46 (33%) 21/47 (45%) 14/48 (29%) |11/59 (19%) 19/68 (28%) 26/60 (43%) 18/61 (30%) |
|FIRST INCIDENCE | 674 624 606 673 |547 590 639 549 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.316N P=0.443 P=0.087 P=0.489N |P=0.364 P=0.344 P=0.042 * P=0.234 |
|POLY 3 | P=0.285N P=0.504N P=0.213 P=0.362N |P=0.356 P=0.225 P=0.031 * P=0.176 |
|POLY 1.5 | P=0.268N P=0.476N P=0.228 P=0.335N |P=0.352 P=0.211 P=0.032 * P=0.169 |
|POLY 6 | P=0.298N P=0.535N P=0.199 P=0.388N |P=0.385 P=0.246 P=0.031 * P=0.199 |
|LOGISTIC REGRESSION| P=0.287N P=0.551N P=0.206 P=0.386N |P=0.369 P=0.237 P=0.044 * P=0.185 |
|COCH-ARM / FISHERS | P=0.245N P=0.430N P=0.252 P=0.295N |P=0.410 P=0.193 P=0.034 * P=0.193 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 4/100 (4%) 6/100 (6%) 3/100 (3%) |6/100 (6%) 3/100 (3%) 2/100 (2%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 5.8% 4.8% 7.0% 3.6% |6.9% 3.4% 2.3% 4.6% |
|TERMINAL (d) | 2/57 (4%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |1/59 (2%) 3/68 (4%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | 649 396 477 565 |462 737 (T) 652 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.348N P=0.565N P=0.458 P=0.418N |P=0.589N P=0.211N P=0.133N P=0.370N |
|POLY 3 | P=0.342N P=0.521N P=0.496 P=0.387N |P=0.588N P=0.236N P=0.137N P=0.377N |
|POLY 1.5 | P=0.334N P=0.513N P=0.497 P=0.376N |P=0.589N P=0.241N P=0.139N P=0.383N |
|POLY 6 | P=0.348N P=0.529N P=0.496 P=0.395N |P=0.581N P=0.230N P=0.135N P=0.364N |
|LOGISTIC REGRESSION| P=0.287N P=0.423N P=0.531 P=0.336N |P=0.417N P=0.292N P=0.138N P=0.233N |
|COCH-ARM / FISHERS | P=0.320N P=0.500N P=0.500 P=0.360N |P=0.576N P=0.249N P=0.140N P=0.374N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 5/100 (5%) 7/100 (7%) 0/100 (0%) |8/100 (8%) 4/100 (4%) 4/100 (4%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 2.3% 6.1% 8.3% 0.0% |9.3% 4.5% 4.6% 5.9% |
|TERMINAL (d) | 2/57 (4%) 2/46 (4%) 5/47 (11%) 0/48 (0%) |5/59 (9%) 4/68 (6%) 1/60 (2%) 4/61 (7%) |
|FIRST INCIDENCE | 736 (T) 596 393 --- |602 737 (T) 637 717 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.066N P=0.167 P=0.055 P=0.277N |P=0.493N P=0.133N P=0.172N P=0.262N |
|POLY 3 | P=0.064N P=0.203 P=0.081 P=0.251N |P=0.506N P=0.167N P=0.175N P=0.291N |
|POLY 1.5 | P=0.061N P=0.209 P=0.083 P=0.246N |P=0.504N P=0.175N P=0.180N P=0.297N |
|POLY 6 | P=0.067N P=0.198 P=0.081 P=0.255N |P=0.501N P=0.158N P=0.167N P=0.275N |
|LOGISTIC REGRESSION| P=0.058N P=0.204 P=0.086 (e) |P=0.494N P=0.156N P=0.178N P=0.274N |
|COCH-ARM / FISHERS | P=0.057N P=0.222 P=0.085 P=0.249N |P=0.478N P=0.186N P=0.186N P=0.284N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 2.3% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 683 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.045 * (e) (e) P=0.256 |
|POLY 3 | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.238 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.235 |
|POLY 6 | (e) (e) (e) (e) |P=0.042 * (e) (e) P=0.245 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.236 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.043 * (e) (e) P=0.249 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |1/100 (1%) 1/100 (1%) 4/100 (4%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 0.0% 0.0% 0.0% |1.2% 1.1% 4.6% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 3/60 (5%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) --- --- --- |737 (T) 582 686 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.606N P=0.543N P=0.538N P=0.534N |P=0.285N P=0.739N P=0.191 P=0.493N |
|POLY 3 | P=0.590N P=0.510N P=0.505N P=0.511N |P=0.288N P=0.749N P=0.190 P=0.501N |
|POLY 1.5 | P=0.592N P=0.507N P=0.503N P=0.507N |P=0.288N P=0.754N P=0.186 P=0.504N |
|POLY 6 | P=0.588N P=0.514N P=0.506N P=0.515N |P=0.282N P=0.742N P=0.195 P=0.495N |
|LOGISTIC REGRESSION| P=0.606N (e) (e) (e) |P=0.280N P=0.738 P=0.196 (e) |
|COCH-ARM / FISHERS | P=0.596N P=0.500N P=0.500N P=0.500N |P=0.274N P=0.751N P=0.184 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/100 (11%) 15/100 (15%) 9/100 (9%) 14/100 (14%)|32/100 (32%) 40/100 (40%) 37/100 (37%) 28/100 (28%) |
|POLY-3 ADJUSTED (b)| 12.8% 17.9% 10.6% 17.1% |35.7% 43.6% 41.2% 32.1% |
|TERMINAL (d) | 10/57 (18%) 10/46 (22%) 7/47 (15%) 13/48 (27%) |21/59 (36%) 31/68 (46%) 27/60 (45%) 17/61 (28%) |
|FIRST INCIDENCE | 583 466 463 516 |494 522 557 533 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.326 P=0.131 P=0.566N P=0.182 |P=0.125N P=0.356 P=0.329 P=0.285N |
|POLY 3 | P=0.346 P=0.237 P=0.422N P=0.280 |P=0.117N P=0.171 P=0.270 P=0.360N |
|POLY 1.5 | P=0.367 P=0.246 P=0.416N P=0.301 |P=0.119N P=0.162 P=0.269 P=0.368N |
|POLY 6 | P=0.327 P=0.228 P=0.424N P=0.261 |P=0.101N P=0.187 P=0.276 P=0.329N |
|LOGISTIC REGRESSION| P=0.365 P=0.237 P=0.428N P=0.260 |P=0.113N P=0.192 P=0.303 P=0.341N |
|COCH-ARM / FISHERS | P=0.397 P=0.264 P=0.407N P=0.335 |P=0.088N P=0.151 P=0.276 P=0.322N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/100 (2%) 0/100 (0%) 1/100 (1%) |1/100 (1%) 1/100 (1%) 3/100 (3%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 2.4% 0.0% 1.2% |1.2% 1.1% 3.3% 2.4% |
|TERMINAL (d) | 2/57 (4%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 0/60 (0%) 2/61 (3%) |
|FIRST INCIDENCE | 736 (T) 534 --- 485 |737 (T) 508 358 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.477N P=0.648 P=0.282N P=0.543N |P=0.444 P=0.742N P=0.307 P=0.512 |
|POLY 3 | P=0.464N P=0.677 P=0.244N P=0.517N |P=0.446 P=0.749N P=0.324 P=0.498 |
|POLY 1.5 | P=0.461N P=0.683 P=0.242N P=0.510N |P=0.446 P=0.754N P=0.317 P=0.494 |
|POLY 6 | P=0.466N P=0.672 P=0.245N P=0.522N |P=0.453 P=0.742N P=0.333 P=0.508 |
|LOGISTIC REGRESSION| P=0.444N P=0.690N (e) P=0.476N |P=0.578N P=0.714 P=0.403 P=0.512 |
|COCH-ARM / FISHERS | P=0.457N P=0.689N P=0.249N P=0.500N |P=0.464 P=0.751N P=0.311 P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/100 (25%) 28/100 (28%) 25/100 (25%) 23/100 (23%)|39/100 (39%) 45/100 (45%) 49/100 (49%) 42/100 (42%) |
|POLY-3 ADJUSTED (b)| 29.0% 33.5% 29.5% 28.3% |44.2% 48.6% 54.9% 48.6% |
|TERMINAL (d) | 23/57 (40%) 22/46 (48%) 22/47 (47%) 22/48 (46%) |31/59 (53%) 35/68 (52%) 40/60 (67%) 33/61 (54%) |
|FIRST INCIDENCE | 647 461 489 673 |533 522 557 606 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.385N P=0.109 P=0.271 P=0.430 |P=0.530 P=0.517 P=0.119 P=0.468 |
|POLY 3 | P=0.370N P=0.316 P=0.536 P=0.529N |P=0.477 P=0.324 P=0.094 P=0.330 |
|POLY 1.5 | P=0.339N P=0.336 P=0.547 P=0.491N |P=0.490 P=0.284 P=0.094 P=0.322 |
|POLY 6 | P=0.399N P=0.296 P=0.530 P=0.565N |P=0.503 P=0.382 P=0.098 P=0.375 |
|LOGISTIC REGRESSION| P=0.362N P=0.249 P=0.519 P=0.555N |P=0.531N P=0.333 P=0.139 P=0.418 |
|COCH-ARM / FISHERS | P=0.298N P=0.374 P=0.565N P=0.434N |P=0.471N P=0.237 P=0.100 P=0.387 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 6/100 (6%) 6/100 (6%) 4/100 (4%) |3/100 (3%) 4/100 (4%) 7/100 (7%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 9.1% 7.2% 7.0% 4.9% |3.5% 4.5% 8.0% 4.7% |
|TERMINAL (d) | 2/57 (4%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 3/68 (4%) 4/60 (7%) 2/61 (3%) |
|FIRST INCIDENCE | 406 490 561 445 |690 619 652 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.233N P=0.465N P=0.427N P=0.228N |P=0.585 P=0.562 P=0.185 P=0.526 |
|POLY 3 | P=0.229N P=0.428N P=0.411N P=0.218N |P=0.577 P=0.525 P=0.175 P=0.501 |
|POLY 1.5 | P=0.220N P=0.415N P=0.405N P=0.205N |P=0.576 P=0.514 P=0.170 P=0.495 |
|POLY 6 | P=0.238N P=0.439N P=0.413N P=0.229N |P=0.588 P=0.538 P=0.182 P=0.515 |
|LOGISTIC REGRESSION| P=0.180N P=0.302N P=0.350N P=0.136N |P=0.565N P=0.513 P=0.173 P=0.562 |
|COCH-ARM / FISHERS | P=0.207N P=0.391N P=0.391N P=0.186N |P=0.592N P=0.500 P=0.166 P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 79/100 (79%) 88/100 (88%) 88/100 (88%) 74/100 (74%)|28/100 (28%) 20/100 (20%) 31/100 (31%) 21/100 (21%) |
|POLY-3 ADJUSTED (b)| 83.9% 94.8% 93.9% 81.8% |32.2% 22.0% 34.4% 24.6% |
|TERMINAL (d) | 49/57 (86%) 46/46 (100%) 46/47 (98%) 44/48 (92%) |20/59 (34%) 12/68 (18%) 19/60 (32%) 14/61 (23%) |
|FIRST INCIDENCE | 406 461 393 442 |625 611 508 696 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.219N P=0.009 ** P=0.021 * P=0.312 |P=0.285N P=0.055N P=0.440 P=0.129N |
|POLY 3 | P=0.015N* P=0.007 ** P=0.014 * P=0.421N |P=0.324N P=0.084N P=0.435 P=0.172N |
|POLY 1.5 | P=0.012N* P=0.017 * P=0.029 * P=0.334N |P=0.314N P=0.099N P=0.406 P=0.182N |
|POLY 6 | P=0.024N* P=0.003 ** P=0.005 ** P=0.545N |P=0.318N P=0.066N P=0.477 P=0.150N |
|LOGISTIC REGRESSION| P=0.034N* P=0.008 ** P=0.019 * P=0.464N |P=0.282N P=0.082N P=0.429 P=0.128N |
|COCH-ARM / FISHERS | P=0.017N* P=0.063 P=0.063 P=0.252N |P=0.250N P=0.123N P=0.378 P=0.162N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/100 (14%) 13/100 (13%) 19/100 (19%) 19/100 (19%)|11/100 (11%) 12/100 (12%) 9/100 (9%) 11/100 (11%) |
|POLY-3 ADJUSTED (b)| 15.9% 15.1% 21.1% 21.5% |12.3% 13.2% 10.1% 12.5% |
|TERMINAL (d) | 8/57 (14%) 2/46 (4%) 5/47 (11%) 3/48 (6%) |1/59 (2%) 5/68 (7%) 0/60 (0%) 4/61 (7%) |
|FIRST INCIDENCE | 476 267 393 442 |533 619 508 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.150 P=0.533 P=0.160 P=0.158 |P=0.558 P=0.580N P=0.378N P=0.579N |
|POLY 3 | P=0.177 P=0.527N P=0.242 P=0.222 |P=0.549 P=0.515 P=0.411N P=0.570 |
|POLY 1.5 | P=0.174 P=0.516N P=0.234 P=0.221 |P=0.549 P=0.508 P=0.411N P=0.567 |
|POLY 6 | P=0.187 P=0.540N P=0.255 P=0.227 |P=0.557 P=0.526 P=0.409N P=0.582 |
|LOGISTIC REGRESSION| P=0.227 P=0.416N P=0.265 P=0.321 |P=0.384N P=0.378 P=0.421N P=0.461N |
|COCH-ARM / FISHERS | P=0.171 P=0.500N P=0.223 P=0.223 |P=0.547N P=0.500 P=0.407N P=0.589N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 5/100 (5%) 2/100 (2%) 4/100 (4%) |5/100 (5%) 7/100 (7%) 4/100 (4%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 5.8% 6.0% 2.4% 4.8% |5.7% 7.7% 4.5% 6.8% |
|TERMINAL (d) | 2/57 (4%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 4/68 (6%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | 693 329 489 442 |494 532 497 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.524N P=0.572 P=0.249N P=0.544N |P=0.513 P=0.441 P=0.489N P=0.485 |
|POLY 3 | P=0.511N P=0.609 P=0.228N P=0.520N |P=0.542 P=0.407 P=0.490N P=0.510 |
|POLY 1.5 | P=0.507N P=0.616 P=0.225N P=0.512N |P=0.537 P=0.396 P=0.495N P=0.501 |
|POLY 6 | P=0.513N P=0.602 P=0.230N P=0.526N |P=0.555 P=0.421 P=0.483N P=0.528 |
|LOGISTIC REGRESSION| P=0.464N P=0.568N P=0.216N P=0.434N |P=0.220N P=0.281 P=0.478N P=0.389N |
|COCH-ARM / FISHERS | P=0.500N P=0.626N P=0.222N P=0.500N |P=0.542 P=0.384 P=0.500N P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |1/100 (1%) 0/100 (0%) 2/100 (2%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 1.2% 0.0% 0.0% 0.0% |1.2% 0.0% 2.3% 1.2% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 2/60 (3%) 1/61 (2%) |
|FIRST INCIDENCE | 736 (T) --- --- --- |660 --- 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.606N P=0.543N P=0.538N P=0.534N |P=0.589 P=0.480N P=0.510 P=0.751N |
|POLY 3 | P=0.590N P=0.510N P=0.505N P=0.511N |P=0.581 P=0.492N P=0.507 P=0.759 |
|POLY 1.5 | P=0.592N P=0.507N P=0.503N P=0.507N |P=0.582 P=0.495N P=0.503 P=0.756 |
|POLY 6 | P=0.588N P=0.514N P=0.506N P=0.515N |P=0.585 P=0.487N P=0.512 P=0.757N |
|LOGISTIC REGRESSION| P=0.606N (e) (e) (e) |P=0.591 P=0.523N P=0.508 P=0.759 |
|COCH-ARM / FISHERS | P=0.596N P=0.500N P=0.500N P=0.500N |P=0.597 P=0.500N P=0.500 P=0.751N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 18/100 (18%) 12/100 (12%) 6/100 (6%) |31/100 (31%) 42/100 (42%) 34/100 (34%) 46/100 (46%) |
|POLY-3 ADJUSTED (b)| 9.3% 22.1% 14.2% 7.3% |35.8% 46.5% 38.2% 53.1% |
|TERMINAL (d) | 7/57 (12%) 15/46 (33%) 9/47 (19%) 4/48 (8%) |26/59 (44%) 35/68 (52%) 25/60 (42%) 39/61 (64%) |
|FIRST INCIDENCE | 722 719 557 442 |591 619 647 557 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.056N P=0.006 ** P=0.137 P=0.498N |P=0.033 * P=0.221 P=0.427 P=0.025 * |
|POLY 3 | P=0.050N P=0.018 * P=0.226 P=0.425N |P=0.030 * P=0.092 P=0.429 P=0.014 * |
|POLY 1.5 | P=0.047N* P=0.021 * P=0.231 P=0.412N |P=0.031 * P=0.082 P=0.403 P=0.013 * |
|POLY 6 | P=0.052N P=0.015 * P=0.224 P=0.436N |P=0.037 * P=0.111 P=0.471 P=0.019 * |
|LOGISTIC REGRESSION| P=0.052N P=0.011 * P=0.215 P=0.439N |P=0.038 * P=0.147 P=0.472 P=0.024 * |
|COCH-ARM / FISHERS | P=0.044N* P=0.028 * P=0.240 P=0.391N |P=0.052 P=0.071 P=0.381 P=0.021 * |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 11/100 (11%) 5/100 (5%) 2/100 (2%) |1/100 (1%) 6/100 (6%) 4/100 (4%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 0.0% 13.4% 5.9% 2.5% |1.2% 6.6% 4.5% 8.0% |
|TERMINAL (d) | 0/57 (0%) 8/46 (17%) 3/47 (6%) 1/48 (2%) |0/59 (0%) 2/68 (3%) 2/60 (3%) 3/61 (5%) |
|FIRST INCIDENCE | --- 534 477 715 |543 522 358 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.143N P<0.001 ** P=0.026 * P=0.219 |P=0.114 P=0.078 P=0.190 P=0.038 * |
|POLY 3 | P=0.140N P<0.001 ** P=0.033 * P=0.226 |P=0.120 P=0.071 P=0.191 P=0.036 * |
|POLY 1.5 | P=0.131N P<0.001 ** P=0.033 * P=0.231 |P=0.116 P=0.066 P=0.187 P=0.034 * |
|POLY 6 | P=0.146N P<0.001 ** P=0.032 * P=0.222 |P=0.129 P=0.077 P=0.196 P=0.040 * |
|LOGISTIC REGRESSION| P=0.126N P<0.001 ** P=0.038 * P=0.221 |P=0.301 P=0.032 * P=0.193 P=0.063 |
|COCH-ARM / FISHERS | P=0.122N P<0.001 ** P=0.030 * P=0.249 |P=0.120 P=0.059 P=0.184 P=0.032 * |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |2/100 (2%) 5/100 (5%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.3% 5.6% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 4/68 (6%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |737 (T) 682 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.061N P=0.279 P=0.235N P=0.232N |
|POLY 3 | (e) (e) (e) (e) |P=0.057N P=0.240 P=0.233N P=0.240N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.059N P=0.232 P=0.236N P=0.242N |
|POLY 6 | (e) (e) (e) (e) |P=0.055N P=0.252 P=0.229N P=0.233N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.058N P=0.259 (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.058N P=0.222 P=0.249N P=0.249N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia Focal Osseous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 4/100 (4%) |1/100 (1%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 4.9% |1.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 544 --- 442 |613 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010 * P=0.489 (e) P=0.055 |P=0.601N P=0.491N P=0.486N P=0.500N |
|POLY 3 | P=0.010 * P=0.491 (e) P=0.058 |P=0.603N P=0.492N P=0.496N P=0.502N |
|POLY 1.5 | P=0.010 * P=0.494 (e) P=0.060 |P=0.600N P=0.495N P=0.498N P=0.504N |
|POLY 6 | P=0.009 ** P=0.488 (e) P=0.056 |P=0.606N P=0.487N P=0.494N P=0.497N |
|LOGISTIC REGRESSION| P=0.013 * P=0.560 (e) P=0.075 |P=0.530N P=0.552N P=0.487N P=0.461N |
|COCH-ARM / FISHERS | P=0.011 * P=0.500 (e) P=0.061 |P=0.596N P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 3/100 (3%) 7/100 (7%) 5/100 (5%) |4/100 (4%) 3/100 (3%) 4/100 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 7.0% 3.7% 8.2% 6.1% |4.7% 3.4% 4.6% 1.2% |
|TERMINAL (d) | 5/57 (9%) 2/46 (4%) 5/47 (11%) 2/48 (4%) |4/59 (7%) 3/68 (4%) 3/60 (5%) 1/61 (2%) |
|FIRST INCIDENCE | 699 466 463 683 |737 (T) 737 (T) 603 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.528 P=0.339N P=0.388 P=0.591N |P=0.170N P=0.424N P=0.629N P=0.172N |
|POLY 3 | P=0.542 P=0.269N P=0.493 P=0.537N |P=0.172N P=0.476N P=0.626N P=0.184N |
|POLY 1.5 | P=0.552 P=0.261N P=0.495 P=0.523N |P=0.172N P=0.486N P=0.633N P=0.187N |
|POLY 6 | P=0.537 P=0.278N P=0.491 P=0.548N |P=0.167N P=0.461N P=0.615N P=0.175N |
|LOGISTIC REGRESSION| P=0.556 P=0.267N P=0.495 P=0.553N |P=0.161N P=0.424N P=0.621N P=0.172N |
|COCH-ARM / FISHERS | P=0.566 P=0.249N P=0.500 P=0.500N |P=0.160N P=0.500N P=0.640N P=0.184N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung: Interstitium |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 5/100 (5%) 3/100 (3%) 4/100 (4%) |10/100 (10%) 20/100 (20%) 13/100 (13%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 7.0% 6.0% 3.6% 4.8% |11.6% 22.0% 14.8% 4.7% |
|TERMINAL (d) | 4/57 (7%) 1/46 (2%) 1/47 (2%) 1/48 (2%) |7/59 (12%) 17/68 (25%) 9/60 (15%) 3/61 (5%) |
|FIRST INCIDENCE | 617 526 496 445 |462 508 673 726 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.442N P=0.584N P=0.319N P=0.446N |P=0.005N** P=0.079 P=0.356 P=0.075N |
|POLY 3 | P=0.416N P=0.529N P=0.258N P=0.395N |P=0.004N** P=0.047 * P=0.344 P=0.086N |
|POLY 1.5 | P=0.412N P=0.519N P=0.254N P=0.386N |P=0.004N** P=0.042 * P=0.335 P=0.089N |
|POLY 6 | P=0.419N P=0.539N P=0.261N P=0.403N |P=0.004N** P=0.055 P=0.359 P=0.078N |
|LOGISTIC REGRESSION| P=0.386N P=0.502N P=0.249N P=0.318N |P=0.004N** P=0.046 * P=0.353 P=0.083N |
|COCH-ARM / FISHERS | P=0.408N P=0.500N P=0.249N P=0.374N |P=0.004N** P=0.037 * P=0.329 P=0.082N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/99 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/99 (0%) 0/100 (0%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 2.3% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.233 |
|POLY 3 | (e) (e) (e) (e) |P=0.042 * (e) (e) P=0.242 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.042 * (e) (e) P=0.238 |
|POLY 6 | (e) (e) (e) (e) |P=0.043 * (e) (e) P=0.249 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.530 (e) (e) P=0.762 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.043 * (e) (e) P=0.249 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/99 (15%) 10/99 (10%) 11/100 (11%) 12/100 (12%)|11/100 (11%) 19/99 (19%) 4/100 (4%) 8/100 (8%) |
|POLY-3 ADJUSTED (b)| 17.6% 12.1% 13.0% 14.4% |12.9% 21.1% 4.5% 9.4% |
|TERMINAL (d) | 14/57 (25%) 6/46 (13%) 7/47 (15%) 7/48 (15%) |10/59 (17%) 16/68 (24%) 2/60 (3%) 7/61 (12%) |
|FIRST INCIDENCE | 658 544 583 445 |697 508 619 690 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.526 P=0.362N P=0.421N P=0.496N |P=0.101N P=0.157 P=0.048N* P=0.282N |
|POLY 3 | P=0.536N P=0.219N P=0.270N P=0.363N |P=0.093N P=0.104 P=0.045N* P=0.317N |
|POLY 1.5 | P=0.528N P=0.211N P=0.265N P=0.350N |P=0.095N P=0.092 P=0.049N* P=0.328N |
|POLY 6 | P=0.540N P=0.224N P=0.272N P=0.370N |P=0.085N P=0.122 P=0.041N* P=0.293N |
|LOGISTIC REGRESSION| P=0.557N P=0.244N P=0.285N P=0.384N |P=0.094N P=0.118 P=0.044N* P=0.261N |
|COCH-ARM / FISHERS | P=0.518N P=0.196N P=0.255N P=0.329N |P=0.088N P=0.078 P=0.052N P=0.315N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 1/99 (1%) 0/100 (0%) 7/100 (7%) |1/100 (1%) 2/99 (2%) 3/100 (3%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 1.2% 0.0% 8.5% |1.2% 2.2% 3.4% 2.4% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 4/48 (8%) |1/59 (2%) 1/68 (2%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | 704 682 --- 516 |737 (T) 590 656 729 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.002 ** P=0.535N P=0.261N P=0.061 |P=0.560 P=0.534 P=0.325 P=0.517 |
|POLY 3 | P=0.002 ** P=0.517N P=0.243N P=0.076 |P=0.555 P=0.516 P=0.317 P=0.498 |
|POLY 1.5 | P=0.002 ** P=0.511N P=0.240N P=0.081 |P=0.554 P=0.507 P=0.312 P=0.494 |
|POLY 6 | P=0.002 ** P=0.523N P=0.245N P=0.073 |P=0.563 P=0.527 P=0.325 P=0.508 |
|LOGISTIC REGRESSION| P=0.003 ** P=0.516N P=0.244N P=0.085 |P=0.564 P=0.484 P=0.310 P=0.524 |
|COCH-ARM / FISHERS | P=0.003 ** P=0.500N P=0.246N P=0.087 |P=0.571 P=0.496 P=0.311 P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/99 (17%) 15/99 (15%) 14/100 (14%) 13/100 (13%)|13/100 (13%) 21/99 (21%) 11/100 (11%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 19.3% 18.2% 16.3% 15.9% |15.0% 22.9% 12.3% 8.1% |
|TERMINAL (d) | 10/57 (18%) 7/46 (15%) 8/47 (17%) 9/48 (19%) |7/59 (12%) 12/68 (18%) 6/60 (10%) 2/61 (3%) |
|FIRST INCIDENCE | 406 544 477 607 |565 532 501 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.367N P=0.541 P=0.494N P=0.417N |P=0.022N* P=0.182 P=0.387N P=0.110N |
|POLY 3 | P=0.346N P=0.505N P=0.373N P=0.346N |P=0.017N* P=0.120 P=0.387N P=0.119N |
|POLY 1.5 | P=0.325N P=0.475N P=0.360N P=0.314N |P=0.017N* P=0.105 P=0.400N P=0.125N |
|POLY 6 | P=0.365N P=0.536N P=0.380N P=0.374N |P=0.015N* P=0.143 P=0.371N P=0.107N |
|LOGISTIC REGRESSION| P=0.317N P=0.448N P=0.329N P=0.293N |P=0.014N* P=0.089 P=0.414N P=0.120N |
|COCH-ARM / FISHERS | P=0.293N P=0.424N P=0.337N P=0.266N |P=0.015N* P=0.088 P=0.414N P=0.119N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 3/99 (3%) 4/100 (4%) 2/100 (2%) |3/100 (3%) 1/99 (1%) 2/100 (2%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.7% 4.8% 2.5% |3.5% 1.1% 2.3% 1.2% |
|TERMINAL (d) | 0/57 (0%) 3/46 (7%) 3/47 (6%) 1/48 (2%) |3/59 (5%) 1/68 (2%) 2/60 (3%) 1/61 (2%) |
|FIRST INCIDENCE | --- 736 (T) 604 703 |737 (T) 737 (T) 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.569 P=0.087 P=0.047 * P=0.216 |P=0.403N P=0.257N P=0.492N P=0.295N |
|POLY 3 | P=0.574 P=0.113 P=0.062 P=0.228 |P=0.407N P=0.293N P=0.490N P=0.309N |
|POLY 1.5 | P=0.585 P=0.116 P=0.063 P=0.233 |P=0.405N P=0.300N P=0.495N P=0.313N |
|POLY 6 | P=0.565 P=0.109 P=0.061 P=0.224 |P=0.404N P=0.283N P=0.482N P=0.298N |
|LOGISTIC REGRESSION| P=0.580 P=0.087 P=0.063 P=0.223 |P=0.403N P=0.257N P=0.492N P=0.295N |
|COCH-ARM / FISHERS | P=0.601 P=0.123 P=0.062 P=0.251 |P=0.388N P=0.314N P=0.500N P=0.311N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/99 (1%) 0/100 (0%) 1/100 (1%) |0/100 (0%) 0/99 (0%) 2/100 (2%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 0.0% 1.2% |0.0% 0.0% 2.3% 2.4% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 2/60 (3%) 1/61 (2%) |
|FIRST INCIDENCE | 736 (T) 619 --- 481 |--- --- 737 (T) 734 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.652 P=0.724 P=0.538N P=0.739 |P=0.161 (e) P=0.243 P=0.251 |
|POLY 3 | P=0.658 P=0.751 P=0.503N P=0.752 |P=0.157 (e) P=0.243 P=0.237 |
|POLY 1.5 | P=0.661 P=0.754 P=0.501N P=0.756 |P=0.157 (e) P=0.241 P=0.235 |
|POLY 6 | P=0.656 P=0.747 P=0.505N P=0.748 |P=0.161 (e) P=0.247 P=0.243 |
|LOGISTIC REGRESSION| P=0.676 P=0.759N (e) P=0.730N |P=0.168 (e) P=0.243 P=0.254 |
|COCH-ARM / FISHERS | P=0.665 P=0.751N P=0.497N P=0.749N |P=0.166 (e) P=0.249 P=0.249 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/99 (2%) 2/100 (2%) 2/100 (2%) |3/100 (3%) 3/99 (3%) 2/99 (2%) 4/99 (4%) |
|POLY-3 ADJUSTED (b)| 2.3% 2.5% 2.4% 2.5% |3.5% 3.4% 2.3% 4.7% |
|TERMINAL (d) | 1/57 (2%) 1/46 (2%) 1/47 (2%) 1/48 (2%) |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 704 490 561 716 |533 674 497 545 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.614 P=0.649 P=0.652 P=0.652 |P=0.376 P=0.625N P=0.486N P=0.505 |
|POLY 3 | P=0.620 P=0.674 P=0.686 P=0.672 |P=0.369 P=0.651N P=0.497N P=0.487 |
|POLY 1.5 | P=0.627 P=0.679 P=0.688 P=0.680 |P=0.368 P=0.657N P=0.501N P=0.482 |
|POLY 6 | P=0.614 P=0.668 P=0.684 P=0.666 |P=0.376 P=0.642N P=0.491N P=0.500 |
|LOGISTIC REGRESSION| P=0.631N P=0.685N P=0.692N P=0.666 |P=0.507 P=0.590 P=0.450N P=0.559 |
|COCH-ARM / FISHERS | P=0.634N P=0.686 P=0.689N P=0.689N |P=0.385 P=0.654 P=0.505N P=0.494 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/99 (1%) 1/100 (1%) 2/100 (2%) |1/100 (1%) 0/99 (0%) 2/99 (2%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 1.2% 2.5% |1.2% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 2/60 (3%) 0/61 (0%) |
|FIRST INCIDENCE | --- 736 (T) 659 736 (T) |494 --- 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.219 P=0.457 P=0.495 P=0.202 |P=0.456N P=0.498N P=0.502 P=0.515N |
|POLY 3 | P=0.222 P=0.488 P=0.496 P=0.226 |P=0.460N P=0.494N P=0.502 P=0.505N |
|POLY 1.5 | P=0.226 P=0.492 P=0.497 P=0.231 |P=0.458N P=0.498N P=0.499 P=0.507N |
|POLY 6 | P=0.217 P=0.484 P=0.495 P=0.222 |P=0.457N P=0.489N P=0.507 P=0.500N |
|LOGISTIC REGRESSION| P=0.221 P=0.457 P=0.506 P=0.202 |P=0.399N P=0.722N P=0.495 P=0.358N |
|COCH-ARM / FISHERS | P=0.233 P=0.497 P=0.500 P=0.249 |P=0.444N P=0.503N P=0.496 P=0.503N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 65/100 (65%) 70/99 (71%) 73/100 (73%) 70/100 (70%)|85/100 (85%) 92/99 (93%) 86/99 (87%) 87/99 (88%) |
|POLY-3 ADJUSTED (b)| 72.0% 76.9% 77.0% 74.5% |88.2% 94.3% 88.9% 90.9% |
|TERMINAL (d) | 48/57 (84%) 41/46 (89%) 38/47 (81%) 37/48 (77%) |55/59 (93%) 64/68 (94%) 56/60 (93%) 56/61 (92%) |
|FIRST INCIDENCE | 476 267 393 410 |462 498 358 233 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.261 P=0.024 * P=0.024 * P=0.056 |P=0.471 P=0.379N P=0.485N P=0.532N |
|POLY 3 | P=0.518N P=0.264 P=0.257 P=0.410 |P=0.563N P=0.090 P=0.529 P=0.347 |
|POLY 1.5 | P=0.518 P=0.259 P=0.200 P=0.349 |P=0.544 P=0.073 P=0.485 P=0.300 |
|POLY 6 | P=0.429N P=0.268 P=0.361 P=0.507 |P=0.517N P=0.126 P=0.585 P=0.426 |
|LOGISTIC REGRESSION| P=0.387 P=0.133 P=0.100 P=0.182 |P=0.474 P=0.087 P=0.446 P=0.251 |
|COCH-ARM / FISHERS | P=0.438 P=0.239 P=0.142 P=0.273 |P=0.481N P=0.059 P=0.431 P=0.350 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/99 (18%) 15/97 (15%) 10/100 (10%) 14/98 (14%) |47/100 (47%) 54/100 (54%) 56/100 (56%) 61/100 (61%) |
|POLY-3 ADJUSTED (b)| 20.4% 18.3% 11.8% 17.3% |51.9% 57.8% 59.9% 69.1% |
|TERMINAL (d) | 7/57 (12%) 4/46 (9%) 3/47 (6%) 5/46 (11%) |29/59 (49%) 41/68 (60%) 36/60 (60%) 44/61 (72%) |
|FIRST INCIDENCE | 581 613 583 516 |543 563 429 579 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.486N P=0.499N P=0.136N P=0.434N |P=0.059 P=0.510 P=0.216 P=0.085 |
|POLY 3 | P=0.461N P=0.438N P=0.090N P=0.373N |P=0.016 * P=0.251 P=0.164 P=0.011 * |
|POLY 1.5 | P=0.437N P=0.415N P=0.082N P=0.339N |P=0.021 * P=0.227 P=0.146 P=0.012 * |
|POLY 6 | P=0.486N P=0.459N P=0.101N P=0.411N |P=0.016 * P=0.284 P=0.188 P=0.013 * |
|LOGISTIC REGRESSION| P=0.438N P=0.390N P=0.076N P=0.315N |P=0.028 * P=0.266 P=0.142 P=0.022 * |
|COCH-ARM / FISHERS | P=0.408N P=0.376N P=0.072N P=0.292N |P=0.059 P=0.198 P=0.129 P=0.032 * |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 2/97 (2%) 1/100 (1%) 2/98 (2%) |0/100 (0%) 2/100 (2%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 1.2% 2.5% |0.0% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 2/46 (4%) |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 624 736 (T) 736 (T) |--- 737 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.341 P=0.217 P=0.462 P=0.193 |P=0.374N P=0.271 (e) (e) |
|POLY 3 | P=0.349 P=0.227 P=0.497 P=0.223 |P=0.362N P=0.249 (e) (e) |
|POLY 1.5 | P=0.357 P=0.229 P=0.499 P=0.228 |P=0.366N P=0.244 (e) (e) |
|POLY 6 | P=0.341 P=0.225 P=0.495 P=0.218 |P=0.355N P=0.255 (e) (e) |
|LOGISTIC REGRESSION| P=0.363 P=0.257 P=0.462 P=0.193 |(e) P=0.271 (e) (e) |
|COCH-ARM / FISHERS | P=0.370 P=0.244 P=0.503 P=0.246 |P=0.367N P=0.249 (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland |
| Galactocele |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 2/97 (2%) 5/100 (5%) 1/98 (1%) |10/100 (10%) 7/100 (7%) 14/100 (14%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 6.0% 1.3% |11.4% 7.8% 15.6% 8.2% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 4/47 (9%) 1/46 (2%) |4/59 (7%) 5/68 (7%) 6/60 (10%) 5/61 (8%) |
|FIRST INCIDENCE | --- 659 718 736 (T) |602 619 488 667 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.539N P=0.208 P=0.024 * P=0.457 |P=0.326N P=0.233N P=0.306 P=0.281N |
|POLY 3 | P=0.532N P=0.225 P=0.032 * P=0.486 |P=0.350N P=0.285N P=0.276 P=0.323N |
|POLY 1.5 | P=0.519N P=0.228 P=0.033 * P=0.491 |P=0.347N P=0.293N P=0.266 P=0.326N |
|POLY 6 | P=0.543N P=0.223 P=0.031 * P=0.481 |P=0.341N P=0.275N P=0.289 P=0.310N |
|LOGISTIC REGRESSION| P=0.531N P=0.229 P=0.031 * P=0.457 |P=0.319N P=0.311N P=0.251 P=0.313N |
|COCH-ARM / FISHERS | P=0.501N P=0.244 P=0.030 * P=0.497 |P=0.309N P=0.307N P=0.257 P=0.307N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/97 (0%) 3/100 (3%) 1/98 (1%) |0/100 (0%) 1/100 (1%) 2/100 (2%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 3.6% 1.3% |0.0% 1.1% 2.3% 2.4% |
|TERMINAL (d) | 2/57 (4%) 0/46 (0%) 1/47 (2%) 0/46 (0%) |0/59 (0%) 1/68 (2%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | 736 (T) --- 557 732 |--- 737 (T) 687 735 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.604N P=0.287N P=0.436 P=0.560N |P=0.289 P=0.528 P=0.248 P=0.249 |
|POLY 3 | P=0.594N P=0.252N P=0.496 P=0.525N |P=0.284 P=0.509 P=0.244 P=0.237 |
|POLY 1.5 | P=0.587N P=0.249N P=0.499 P=0.516N |P=0.282 P=0.505 P=0.241 P=0.235 |
|POLY 6 | P=0.600N P=0.255N P=0.495 P=0.533N |P=0.291 P=0.514 P=0.248 P=0.243 |
|LOGISTIC REGRESSION| P=0.595N (e) P=0.499 P=0.542N |P=0.290 P=0.528 P=0.243 P=0.254 |
|COCH-ARM / FISHERS | P=0.579N P=0.254N P=0.505 P=0.504N |P=0.293 P=0.500 P=0.249 P=0.249 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/97 (0%) 0/100 (0%) 0/98 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/46 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 303 --- --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.365N P=0.250N P=0.243N P=0.244N |(e) (e) (e) (e) |
|POLY 3 | P=0.359N P=0.256N P=0.245N P=0.258N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.361N P=0.251N P=0.242N P=0.251N |(e) (e) (e) (e) |
|POLY 6 | P=0.358N P=0.260N P=0.248N P=0.264N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.392N P=0.145N P=0.228N P=0.202N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.365N P=0.254N P=0.246N P=0.251N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mammary Gland: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/99 (9%) 1/97 (1%) 4/100 (4%) 3/98 (3%) |1/100 (1%) 4/100 (4%) 3/100 (3%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 10.6% 1.3% 4.8% 3.8% |1.2% 4.5% 3.4% 2.3% |
|TERMINAL (d) | 8/57 (14%) 1/46 (2%) 2/47 (4%) 3/46 (7%) |1/59 (2%) 3/68 (4%) 2/60 (3%) 1/61 (2%) |
|FIRST INCIDENCE | 722 736 (T) 694 736 (T) |737 (T) 631 656 522 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.344N P=0.024N* P=0.192N P=0.124N |P=0.515N P=0.226 P=0.318 P=0.502 |
|POLY 3 | P=0.306N P=0.013N* P=0.129N P=0.084N |P=0.507N P=0.197 P=0.316 P=0.501 |
|POLY 1.5 | P=0.300N P=0.013N* P=0.126N P=0.078N |P=0.512N P=0.191 P=0.312 P=0.495 |
|POLY 6 | P=0.312N P=0.014N* P=0.130N P=0.090N |P=0.495N P=0.207 P=0.323 P=0.512 |
|LOGISTIC REGRESSION| P=0.328N P=0.016N* P=0.132N P=0.096N |P=0.505N P=0.197 P=0.318 P=0.513 |
|COCH-ARM / FISHERS | P=0.294N P=0.010N* P=0.121N P=0.069N |P=0.501N P=0.184 P=0.311 P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/17 (82%) 15/22 (68%) 23/27 (85%) 15/21 (71%) |9/11 (82%) 4/6 (67%) 4/5 (80%) 10/13 (77%) |
|POLY-3 ADJUSTED (b)| 84.7% 77.1% 90.5% 79.3% |88.1% 66.7% 80.0% 78.5% |
|TERMINAL (d) | 5/6 (83%) 9/10 (90%) 11/12 (92%) 7/9 (78%) |6/6 (100%) 4/6 (67%) 2/3 (67%) 9/11 (82%) |
|FIRST INCIDENCE | 581 267 393 410 |598 737 (T) 648 485 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.476N P=0.422N P=0.265 P=0.527N |P=0.508N P=0.030N* P=0.272N P=0.150N |
|POLY 3 | P=0.487N P=0.436N P=0.463 P=0.510N |P=0.606N P=0.343N P=0.637N P=0.479N |
|POLY 1.5 | P=0.464N P=0.352N P=0.507 P=0.442N |P=0.609N P=0.385N P=0.671N P=0.513N |
|POLY 6 | P=0.482N P=0.570N P=0.427 P=0.570N |P=0.620N P=0.308N P=0.604N P=0.464N |
|LOGISTIC REGRESSION| P=0.465N P=0.310N P=0.535 P=0.396N |P=0.620N P=0.290N P=0.641N P=0.510N |
|COCH-ARM / FISHERS | P=0.416N P=0.265N P=0.559 P=0.346N |P=0.635N P=0.445N P=0.705N P=0.585N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/100 (27%) 28/98 (29%) 40/100 (40%) 29/100 (29%)|9/100 (9%) 10/100 (10%) 11/100 (11%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 30.2% 33.0% 44.8% 33.3% |10.2% 11.0% 12.5% 7.0% |
|TERMINAL (d) | 17/57 (30%) 11/45 (24%) 18/47 (38%) 11/48 (23%) |3/59 (5%) 6/68 (9%) 8/60 (13%) 3/61 (5%) |
|FIRST INCIDENCE | 502 461 393 442 |462 498 508 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.471 P=0.260 P=0.016 * P=0.260 |P=0.199N P=0.585 P=0.425 P=0.288N |
|POLY 3 | P=0.532N P=0.404 P=0.028 * P=0.388 |P=0.208N P=0.524 P=0.405 P=0.319N |
|POLY 1.5 | P=0.518N P=0.423 P=0.031 * P=0.406 |P=0.205N P=0.513 P=0.404 P=0.320N |
|POLY 6 | P=0.541N P=0.394 P=0.028 * P=0.378 |P=0.201N P=0.540 P=0.408 P=0.308N |
|LOGISTIC REGRESSION| P=0.509N P=0.448 P=0.033 * P=0.442 |P=0.158N P=0.399 P=0.395 P=0.263N |
|COCH-ARM / FISHERS | P=0.501N P=0.465 P=0.036 * P=0.437 |P=0.176N P=0.500 P=0.407 P=0.296N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Nose |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/98 (2%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/45 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 682 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.373N P=0.230 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.380N P=0.222 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.374N P=0.227 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.385N P=0.219 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.369N P=0.226 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.366N P=0.244 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/100 (7%) 8/98 (8%) 13/100 (13%) 10/100 (10%)|2/100 (2%) 9/100 (9%) 6/100 (6%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 8.1% 9.8% 15.4% 12.1% |2.3% 9.9% 6.8% 1.2% |
|TERMINAL (d) | 6/57 (11%) 3/45 (7%) 8/47 (17%) 5/48 (10%) |1/59 (2%) 4/68 (6%) 4/60 (7%) 1/61 (2%) |
|FIRST INCIDENCE | 647 466 583 494 |591 508 647 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.328 P=0.372 P=0.064 P=0.217 |P=0.057N P=0.048 * P=0.152 P=0.499N |
|POLY 3 | P=0.349 P=0.460 P=0.108 P=0.275 |P=0.054N P=0.038 * P=0.146 P=0.504N |
|POLY 1.5 | P=0.361 P=0.468 P=0.112 P=0.286 |P=0.055N P=0.034 * P=0.142 P=0.507N |
|POLY 6 | P=0.344 P=0.453 P=0.106 P=0.268 |P=0.050N P=0.043 * P=0.152 P=0.495N |
|LOGISTIC REGRESSION| P=0.368 P=0.496 P=0.104 P=0.277 |P=0.046N* P=0.020 * P=0.141 P=0.501N |
|COCH-ARM / FISHERS | P=0.380 P=0.484 P=0.119 P=0.307 |P=0.051N P=0.029 * P=0.140 P=0.500N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 36/100 (36%) 32/98 (33%) 48/100 (48%) 41/100 (41%)|69/100 (69%) 83/100 (83%) 87/100 (87%) 74/100 (74%) |
|POLY-3 ADJUSTED (b)| 40.2% 38.0% 55.3% 48.6% |73.9% 87.2% 90.8% 81.5% |
|TERMINAL (d) | 24/57 (42%) 17/45 (38%) 27/47 (57%) 24/48 (50%) |46/59 (78%) 62/68 (91%) 57/60 (95%) 50/61 (82%) |
|FIRST INCIDENCE | 406 329 586 410 |462 498 358 394 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.167 P=0.449 P=0.016 * P=0.112 |P=0.427N P=0.320 P=0.035 * P=0.419 |
|POLY 3 | P=0.143 P=0.442N P=0.027 * P=0.162 |P=0.512N P=0.010 * P<0.001 ** P=0.128 |
|POLY 1.5 | P=0.179 P=0.411N P=0.036 * P=0.206 |P=0.477N P=0.012 * P<0.001 ** P=0.142 |
|POLY 6 | P=0.112 P=0.477N P=0.022 * P=0.125 |P=0.491N P=0.011 * P<0.001 ** P=0.143 |
|LOGISTIC REGRESSION| P=0.173 P=0.420N P=0.035 * P=0.178 |P=0.500N P=0.032 * P=0.002 ** P=0.177 |
|COCH-ARM / FISHERS | P=0.239 P=0.365N P=0.057 P=0.281 |P=0.269N P=0.015 * P=0.002 ** P=0.266 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 1/98 (1%) 1/100 (1%) 0/100 (0%) |4/100 (4%) 1/100 (1%) 3/100 (3%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 3.5% 1.2% 1.2% 0.0% |4.6% 1.1% 3.4% 5.7% |
|TERMINAL (d) | 2/57 (4%) 0/45 (0%) 0/47 (0%) 0/48 (0%) |3/59 (5%) 0/68 (0%) 2/60 (3%) 2/61 (3%) |
|FIRST INCIDENCE | 710 329 496 --- |495 563 728 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.171N P=0.353N P=0.344N P=0.149N |P=0.172 P=0.156N P=0.491N P=0.495 |
|POLY 3 | P=0.164N P=0.331N P=0.313N P=0.132N |P=0.180 P=0.169N P=0.492N P=0.508 |
|POLY 1.5 | P=0.163N P=0.324N P=0.311N P=0.128N |P=0.178 P=0.175N P=0.497N P=0.497 |
|POLY 6 | P=0.165N P=0.338N P=0.315N P=0.135N |P=0.186 P=0.161N P=0.484N P=0.529 |
|LOGISTIC REGRESSION| P=0.154N P=0.267N P=0.299N P=0.136N |P=0.306 P=0.220N P=0.496N P=0.615 |
|COCH-ARM / FISHERS | P=0.161N P=0.318N P=0.311N P=0.123N |P=0.188 P=0.184N P=0.500N P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |4/100 (4%) 3/100 (3%) 4/100 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| |4.7% 3.4% 4.6% 1.2% |
|TERMINAL (d) | |4/59 (7%) 3/68 (4%) 4/60 (7%) 1/61 (2%) |
|FIRST INCIDENCE | |737 (T) 737 (T) 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.169N P=0.424N P=0.633N P=0.172N |
|POLY 3 | |P=0.171N P=0.476N P=0.628N P=0.184N |
|POLY 1.5 | |P=0.172N P=0.486N P=0.635N P=0.187N |
|POLY 6 | |P=0.166N P=0.461N P=0.619N P=0.175N |
|LOGISTIC REGRESSION| |P=0.169N P=0.424N P=0.633N P=0.172N |
|COCH-ARM / FISHERS | |P=0.160N P=0.500N P=0.640N P=0.184N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |0/100 (0%) 0/100 (0%) 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| |0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | |--- --- 681 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.635N (e) P=0.252 (e) |
|POLY 3 | |P=0.644N (e) P=0.244 (e) |
|POLY 1.5 | |P=0.644N (e) P=0.241 (e) |
|POLY 6 | |P=0.639N (e) P=0.248 (e) |
|LOGISTIC REGRESSION| |P=0.640N (e) P=0.242 (e) |
|COCH-ARM / FISHERS | |P=0.634N (e) P=0.249 (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary: Follicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |3/100 (3%) 5/100 (5%) 2/100 (2%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| |3.5% 5.6% 2.3% 4.7% |
|TERMINAL (d) | |2/59 (3%) 5/68 (7%) 2/60 (3%) 3/61 (5%) |
|FIRST INCIDENCE | |553 737 (T) 737 (T) 606 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.530 P=0.430 P=0.493N P=0.508 |
|POLY 3 | |P=0.539 P=0.380 P=0.493N P=0.496 |
|POLY 1.5 | |P=0.536 P=0.371 P=0.497N P=0.490 |
|POLY 6 | |P=0.550 P=0.393 P=0.487N P=0.511 |
|LOGISTIC REGRESSION| |P=0.537 P=0.383 P=0.497N P=0.497 |
|COCH-ARM / FISHERS | |P=0.552 P=0.360 P=0.500N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary: Periovarian Tissue |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |6/100 (6%) 8/100 (8%) 12/100 (12%) 8/100 (8%) |
|POLY-3 ADJUSTED (b)| |7.0% 8.9% 13.6% 9.3% |
|TERMINAL (d) | |6/59 (10%) 6/68 (9%) 5/60 (8%) 4/61 (7%) |
|FIRST INCIDENCE | |737 (T) 563 617 649 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.518 P=0.492 P=0.127 P=0.425 |
|POLY 3 | |P=0.510 P=0.432 P=0.122 P=0.393 |
|POLY 1.5 | |P=0.505 P=0.414 P=0.114 P=0.381 |
|POLY 6 | |P=0.533 P=0.456 P=0.134 P=0.421 |
|LOGISTIC REGRESSION| |P=0.509 P=0.439 P=0.122 P=0.402 |
|COCH-ARM / FISHERS | |P=0.535 P=0.391 P=0.108 P=0.391 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary: Rete Ovarii |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |8/100 (8%) 16/100 (16%) 8/100 (8%) 15/100 (15%) |
|POLY-3 ADJUSTED (b)| |9.3% 17.7% 9.1% 17.6% |
|TERMINAL (d) | |6/59 (10%) 12/68 (18%) 5/60 (8%) 12/61 (20%) |
|FIRST INCIDENCE | |673 631 686 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.199 P=0.121 P=0.578N P=0.111 |
|POLY 3 | |P=0.191 P=0.079 P=0.584N P=0.086 |
|POLY 1.5 | |P=0.189 P=0.071 P=0.593N P=0.082 |
|POLY 6 | |P=0.204 P=0.090 P=0.569N P=0.097 |
|LOGISTIC REGRESSION| |P=0.200 P=0.089 P=0.569N P=0.105 |
|COCH-ARM / FISHERS | |P=0.213 P=0.063 P=0.602N P=0.091 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/98 (3%) 0/99 (0%) 1/99 (1%) 1/99 (1%) |0/100 (0%) 0/100 (0%) 0/99 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 3.5% 0.0% 1.2% 1.2% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 647 --- 728 736 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.557N P=0.146N P=0.336N P=0.352N |(e) (e) (e) (e) |
|POLY 3 | P=0.541N P=0.132N P=0.314N P=0.329N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.540N P=0.127N P=0.309N P=0.318N |(e) (e) (e) (e) |
|POLY 6 | P=0.540N P=0.137N P=0.319N P=0.339N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.555N P=0.125N P=0.309N P=0.323N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.541N P=0.121N P=0.307N P=0.307N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/98 (5%) 14/99 (14%) 13/99 (13%) 9/99 (9%) |14/100 (14%) 10/100 (10%) 9/99 (9%) 9/100 (9%) |
|POLY-3 ADJUSTED (b)| 5.9% 17.2% 15.4% 11.1% |16.1% 11.0% 10.3% 10.5% |
|TERMINAL (d) | 5/57 (9%) 11/46 (24%) 11/47 (23%) 6/48 (13%) |10/59 (17%) 7/68 (10%) 8/60 (13%) 7/61 (12%) |
|FIRST INCIDENCE | 736 (T) 396 479 551 |533 532 617 427 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.514N P=0.008 ** P=0.015 * P=0.126 |P=0.320N P=0.175N P=0.176N P=0.173N |
|POLY 3 | P=0.494N P=0.019 * P=0.038 * P=0.178 |P=0.321N P=0.219N P=0.182N P=0.192N |
|POLY 1.5 | P=0.477N P=0.022 * P=0.040 * P=0.189 |P=0.320N P=0.235N P=0.189N P=0.200N |
|POLY 6 | P=0.505N P=0.016 * P=0.036 * P=0.169 |P=0.313N P=0.198N P=0.171N P=0.174N |
|LOGISTIC REGRESSION| P=0.495N P=0.017 * P=0.036 * P=0.165 |P=0.310N P=0.249N P=0.176N P=0.195N |
|COCH-ARM / FISHERS | P=0.448N P=0.027 * P=0.043 * P=0.209 |P=0.288N P=0.257N P=0.195N P=0.188N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas |
| Metaplasia Hepatocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 0/99 (0%) 0/99 (0%) 0/99 (0%) |0/100 (0%) 0/100 (0%) 2/99 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- 694 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.632N (e) P=0.251 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.643N (e) P=0.242 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.644N (e) P=0.239 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.638N (e) P=0.247 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.640N (e) P=0.243 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.634N (e) P=0.246 (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 3/99 (3%) 1/99 (1%) 1/99 (1%) |0/100 (0%) 3/100 (3%) 1/99 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.7% 1.2% 1.2% |0.0% 3.4% 1.2% 2.4% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 3/68 (4%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | --- 596 586 736 (T) |--- 737 (T) 665 735 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.570N P=0.102 P=0.491 P=0.466 |P=0.490 P=0.149 P=0.513 P=0.249 |
|POLY 3 | P=0.567N P=0.114 P=0.498 P=0.489 |P=0.495 P=0.130 P=0.504 P=0.237 |
|POLY 1.5 | P=0.558N P=0.117 P=0.500 P=0.494 |P=0.491 P=0.126 P=0.501 P=0.235 |
|POLY 6 | P=0.575N P=0.111 P=0.497 P=0.484 |P=0.505 P=0.135 P=0.508 P=0.243 |
|LOGISTIC REGRESSION| P=0.530N P=0.138 P=0.502 P=0.466 |P=0.495 P=0.149 P=0.496 P=0.254 |
|COCH-ARM / FISHERS | P=0.543N P=0.125 P=0.503 P=0.503 |P=0.499 P=0.123 P=0.497 P=0.249 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/98 (34%) 26/99 (26%) 40/99 (40%) 27/99 (27%) |15/100 (15%) 18/100 (18%) 26/99 (26%) 16/100 (16%) |
|POLY-3 ADJUSTED (b)| 36.7% 30.8% 44.8% 32.0% |17.2% 19.9% 29.1% 18.8% |
|TERMINAL (d) | 19/57 (33%) 11/46 (24%) 17/47 (36%) 17/48 (35%) |10/59 (17%) 15/68 (22%) 17/60 (28%) 11/61 (18%) |
|FIRST INCIDENCE | 303 396 393 442 |553 508 501 668 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.371N P=0.405N P=0.098 P=0.437N |P=0.428N P=0.505 P=0.056 P=0.545 |
|POLY 3 | P=0.325N P=0.252N P=0.165 P=0.310N |P=0.457N P=0.390 P=0.042 * P=0.471 |
|POLY 1.5 | P=0.294N P=0.218N P=0.178 P=0.267N |P=0.451N P=0.374 P=0.039 * P=0.466 |
|POLY 6 | P=0.361N P=0.286N P=0.162 P=0.356N |P=0.444N P=0.411 P=0.049 * P=0.491 |
|LOGISTIC REGRESSION| P=0.266N P=0.164N P=0.208 P=0.202N |P=0.428N P=0.387 P=0.039 * P=0.500 |
|COCH-ARM / FISHERS | P=0.256N P=0.164N P=0.203 P=0.206N |P=0.387N P=0.352 P=0.036 * P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/98 (1%) 1/99 (1%) 1/99 (1%) 0/99 (0%) |0/100 (0%) 0/100 (0%) 2/99 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 1.2% 0.0% |0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 2/60 (3%) 0/61 (0%) |
|FIRST INCIDENCE | 693 736 (T) 666 --- |--- --- 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.348N P=0.726 P=0.759 P=0.515N |P=0.642N (e) P=0.243 (e) |
|POLY 3 | P=0.345N P=0.748 P=0.757 P=0.511N |P=0.643N (e) P=0.242 (e) |
|POLY 1.5 | P=0.342N P=0.754 P=0.760 P=0.506N |P=0.644N (e) P=0.239 (e) |
|POLY 6 | P=0.349N P=0.742 P=0.756 P=0.516N |P=0.638N (e) P=0.246 (e) |
|LOGISTIC REGRESSION| P=0.341N P=0.747 P=0.757N P=0.503N |(e) (e) P=0.243 (e) |
|COCH-ARM / FISHERS | P=0.336N P=0.749N P=0.749N P=0.497N |P=0.634N (e) P=0.246 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/98 (20%) 21/99 (21%) 23/99 (23%) 20/99 (20%) |3/100 (3%) 5/100 (5%) 5/99 (5%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 23.5% 25.5% 27.2% 24.7% |3.5% 5.6% 5.8% 1.2% |
|TERMINAL (d) | 17/57 (30%) 15/46 (33%) 17/47 (36%) 17/48 (35%) |2/59 (3%) 5/68 (7%) 5/60 (8%) 0/61 (0%) |
|FIRST INCIDENCE | 670 526 489 656 |655 737 (T) 737 (T) 579 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.528 P=0.257 P=0.169 P=0.350 |P=0.127N P=0.434 P=0.370 P=0.303N |
|POLY 3 | P=0.545N P=0.451 P=0.347 P=0.495 |P=0.123N P=0.382 P=0.365 P=0.308N |
|POLY 1.5 | P=0.514N P=0.475 P=0.361 P=0.531 |P=0.126N P=0.372 P=0.359 P=0.313N |
|POLY 6 | P=0.528 P=0.426 P=0.333 P=0.464 |P=0.117N P=0.395 P=0.374 P=0.297N |
|LOGISTIC REGRESSION| P=0.547 P=0.394 P=0.324 P=0.451 |P=0.122N P=0.406 P=0.382 P=0.301N |
|COCH-ARM / FISHERS | P=0.469N P=0.515 P=0.379 P=0.556N |P=0.117N P=0.360 P=0.355 P=0.311N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/98 (1%) 2/99 (2%) 0/99 (0%) 2/99 (2%) |0/100 (0%) 0/100 (0%) 1/99 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 2.5% 0.0% 2.5% |0.0% 0.0% 1.2% 0.0% |
|TERMINAL (d) | 1/57 (2%) 1/46 (2%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) 490 --- 721 |--- --- 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.440 P=0.448 P=0.538N P=0.454 |P=0.771N (e) P=0.503 (e) |
|POLY 3 | P=0.441 P=0.485 P=0.503N P=0.481 |P=0.771N (e) P=0.503 (e) |
|POLY 1.5 | P=0.448 P=0.492 P=0.501N P=0.490 |P=0.771N (e) P=0.500 (e) |
|POLY 6 | P=0.436 P=0.477 P=0.505N P=0.473 |P=0.768N (e) P=0.507 (e) |
|LOGISTIC REGRESSION| P=0.457 P=0.530 (e) P=0.471 |(e) (e) P=0.503 (e) |
|COCH-ARM / FISHERS | P=0.458 P=0.504 P=0.497N P=0.504 |P=0.766N (e) P=0.497 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pineal Gland |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/81 (1%) 1/84 (1%) 2/81 (2%) 0/79 (0%) |0/85 (0%) 0/90 (0%) 0/85 (0%) 0/90 (0%) |
|POLY-3 ADJUSTED (b)| 1.5% 1.4% 2.9% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/43 (2%) 1/41 (2%) 2/37 (5%) 0/35 (0%) |0/51 (0%) 0/61 (0%) 0/52 (0%) 0/57 (0%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.358N P=0.751 P=0.448 P=0.541N |(e) (e) (e) (e) |
|POLY 3 | P=0.339N P=0.757N P=0.500 P=0.516N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.332N P=0.756N P=0.499 P=0.512N |(e) (e) (e) (e) |
|POLY 6 | P=0.344N P=0.756N P=0.503 P=0.519N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.358N P=0.751 P=0.448 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.324N P=0.742N P=0.500 P=0.506N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pineal Gland |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/81 (52%) 52/84 (62%) 54/81 (67%) 39/79 (49%) |56/85 (66%) 54/90 (60%) 57/85 (67%) 54/90 (60%) |
|POLY-3 ADJUSTED (b)| 56.2% 68.3% 73.0% 56.6% |69.9% 63.7% 71.7% 65.3% |
|TERMINAL (d) | 21/43 (49%) 25/41 (61%) 27/37 (73%) 23/35 (66%) |35/51 (69%) 40/61 (66%) 39/52 (75%) 38/57 (67%) |
|FIRST INCIDENCE | 502 505 520 445 |495 508 556 233 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.290N P=0.074 P=0.029 * P=0.403 |P=0.397N P=0.126N P=0.514N P=0.243N |
|POLY 3 | P=0.173N P=0.080 P=0.020 * P=0.552 |P=0.404N P=0.242N P=0.467 P=0.317N |
|POLY 1.5 | P=0.129N P=0.090 P=0.025 * P=0.516N |P=0.404N P=0.246N P=0.475 P=0.318N |
|POLY 6 | P=0.263N P=0.079 P=0.018 * P=0.464 |P=0.381N P=0.242N P=0.467 P=0.301N |
|LOGISTIC REGRESSION| P=0.142N P=0.107 P=0.035 * P=0.480N |P=0.404N P=0.221N P=0.566N P=0.286N |
|COCH-ARM / FISHERS | P=0.105N P=0.126 P=0.039 * P=0.438N |P=0.319N P=0.259N P=0.500 P=0.259N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Angiectasis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/98 (3%) 2/95 (2%) 4/97 (4%) 2/100 (2%) |1/99 (1%) 9/99 (9%) 5/98 (5%) 3/98 (3%) |
|POLY-3 ADJUSTED (b)| 3.6% 2.6% 5.0% 2.5% |1.2% 10.2% 5.7% 3.6% |
|TERMINAL (d) | 2/57 (4%) 1/45 (2%) 4/46 (9%) 1/48 (2%) |1/59 (2%) 9/67 (13%) 2/60 (3%) 3/61 (5%) |
|FIRST INCIDENCE | 701 715 736 (T) 733 |737 (T) 737 (T) 501 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.494N P=0.571N P=0.402 P=0.564N |P=0.295N P=0.018 * P=0.117 P=0.318 |
|POLY 3 | P=0.468N P=0.538N P=0.477 P=0.518N |P=0.293N P=0.012 * P=0.113 P=0.301 |
|POLY 1.5 | P=0.461N P=0.529N P=0.484 P=0.507N |P=0.299N P=0.012 * P=0.108 P=0.297 |
|POLY 6 | P=0.474N P=0.548N P=0.470 P=0.527N |P=0.278N P=0.013 * P=0.119 P=0.311 |
|LOGISTIC REGRESSION| P=0.472N P=0.552N P=0.467 P=0.529N |P=0.299N P=0.018 * P=0.101 P=0.318 |
|COCH-ARM / FISHERS | P=0.450N P=0.515N P=0.494 P=0.490N |P=0.286N P=0.009 ** P=0.103 P=0.307 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/98 (8%) 6/95 (6%) 6/97 (6%) 16/100 (16%)|21/99 (21%) 21/99 (21%) 19/98 (19%) 28/98 (29%) |
|POLY-3 ADJUSTED (b)| 9.4% 7.6% 7.4% 19.1% |24.2% 23.6% 22.0% 32.3% |
|TERMINAL (d) | 4/57 (7%) 2/45 (4%) 4/46 (9%) 8/48 (17%) |16/59 (27%) 19/67 (28%) 17/60 (28%) 20/61 (33%) |
|FIRST INCIDENCE | 627 544 606 461 |462 662 673 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.005 ** P=0.511N P=0.500N P=0.037 * |P=0.069 P=0.396N P=0.399N P=0.198 |
|POLY 3 | P=0.006 ** P=0.455N P=0.428N P=0.053 |P=0.071 P=0.534N P=0.432N P=0.152 |
|POLY 1.5 | P=0.006 ** P=0.440N P=0.416N P=0.059 |P=0.066 P=0.550N P=0.440N P=0.138 |
|POLY 6 | P=0.006 ** P=0.473N P=0.442N P=0.048 * |P=0.088 P=0.511N P=0.421N P=0.189 |
|LOGISTIC REGRESSION| P=0.007 ** P=0.415N P=0.409N P=0.068 |P=0.061 P=0.488N P=0.386N P=0.138 |
|COCH-ARM / FISHERS | P=0.007 ** P=0.415N P=0.399N P=0.070 |P=0.079 P=0.569N P=0.444N P=0.152 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/98 (11%) 15/95 (16%) 9/97 (9%) 14/100 (14%)|10/99 (10%) 9/99 (9%) 6/98 (6%) 6/98 (6%) |
|POLY-3 ADJUSTED (b)| 12.8% 18.9% 10.8% 16.8% |11.6% 10.2% 7.0% 7.2% |
|TERMINAL (d) | 6/57 (11%) 8/45 (18%) 3/46 (7%) 8/48 (17%) |6/59 (10%) 9/67 (13%) 6/60 (10%) 5/61 (8%) |
|FIRST INCIDENCE | 502 396 405 445 |597 737 (T) 737 (T) 696 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.355 P=0.153 P=0.501N P=0.231 |P=0.235N P=0.400N P=0.202N P=0.201N |
|POLY 3 | P=0.403 P=0.195 P=0.435N P=0.305 |P=0.248N P=0.479N P=0.217N P=0.235N |
|POLY 1.5 | P=0.419 P=0.211 P=0.427N P=0.325 |P=0.249N P=0.488N P=0.220N P=0.239N |
|POLY 6 | P=0.389 P=0.181 P=0.442N P=0.287 |P=0.237N P=0.469N P=0.213N P=0.221N |
|LOGISTIC REGRESSION| P=0.440 P=0.218 P=0.399N P=0.343 |P=0.232N P=0.460N P=0.209N P=0.228N |
|COCH-ARM / FISHERS | P=0.441 P=0.237 P=0.417N P=0.355 |P=0.226N P=0.500N P=0.224N P=0.224N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hypertrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/98 (2%) 2/95 (2%) 3/97 (3%) 0/100 (0%) |0/99 (0%) 0/99 (0%) 0/98 (0%) 1/98 (1%) |
|POLY-3 ADJUSTED (b)| 2.4% 2.6% 3.7% 0.0% |0.0% 0.0% 0.0% 1.2% |
|TERMINAL (d) | 1/57 (2%) 1/45 (2%) 1/46 (2%) 0/48 (0%) |0/59 (0%) 0/67 (0%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 696 581 682 --- |--- --- --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.167N P=0.639 P=0.462 P=0.264N |P=0.230 (e) (e) P=0.507 |
|POLY 3 | P=0.157N P=0.664 P=0.482 P=0.247N |P=0.228 (e) (e) P=0.497 |
|POLY 1.5 | P=0.153N P=0.670 P=0.487 P=0.242N |P=0.227 (e) (e) P=0.494 |
|POLY 6 | P=0.161N P=0.658 P=0.479 P=0.252N |P=0.231 (e) (e) P=0.503 |
|LOGISTIC REGRESSION| P=0.150N P=0.680 P=0.482 P=0.250N |(e) (e) (e) P=0.507 |
|COCH-ARM / FISHERS | P=0.147N P=0.678 P=0.495 P=0.244N |P=0.232 (e) (e) P=0.497 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 0/95 (0%) 0/97 (0%) 0/100 (0%) |0/99 (0%) 2/99 (2%) 0/98 (0%) 1/98 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.2% 0.0% 1.2% |
|TERMINAL (d) | 0/57 (0%) 0/45 (0%) 0/46 (0%) 0/48 (0%) |0/59 (0%) 1/67 (2%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | --- --- --- --- |--- 522 --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.653 P=0.255 (e) P=0.507 |
|POLY 3 | (e) (e) (e) (e) |P=0.659 P=0.249 (e) P=0.497 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.656 P=0.244 (e) P=0.494 |
|POLY 6 | (e) (e) (e) (e) |P=0.667 P=0.255 (e) P=0.503 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.692 P=0.196 (e) P=0.507 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.660 P=0.249 (e) P=0.497 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 58
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 0/95 (0%) 0/97 (0%) 0/100 (0%) |2/99 (2%) 1/99 (1%) 0/98 (0%) 2/98 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.3% 1.1% 0.0% 2.4% |
|TERMINAL (d) | 0/57 (0%) 0/45 (0%) 0/46 (0%) 0/48 (0%) |1/59 (2%) 1/67 (2%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | --- --- --- --- |680 737 (T) --- 485 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.447 P=0.460N P=0.229N P=0.685N |
|POLY 3 | (e) (e) (e) (e) |P=0.444 P=0.487N P=0.236N P=0.689 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.444 P=0.493N P=0.238N P=0.684 |
|POLY 6 | (e) (e) (e) (e) |P=0.449 P=0.480N P=0.232N P=0.686N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.479 P=0.483N P=0.237N P=0.680N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.453 P=0.500N P=0.251N P=0.686 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/98 (3%) 0/95 (0%) 1/97 (1%) 0/100 (0%) |0/99 (0%) 0/99 (0%) 0/98 (0%) 0/98 (0%) |
|POLY-3 ADJUSTED (b)| 3.5% 0.0% 1.2% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/57 (4%) 0/45 (0%) 0/46 (0%) 0/48 (0%) |0/59 (0%) 0/67 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 619 --- 724 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.242N P=0.160N P=0.351N P=0.152N |(e) (e) (e) (e) |
|POLY 3 | P=0.221N P=0.138N P=0.323N P=0.129N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.222N P=0.134N P=0.318N P=0.124N |(e) (e) (e) (e) |
|POLY 6 | P=0.220N P=0.142N P=0.328N P=0.133N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.229N P=0.132N P=0.319N P=0.124N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.224N P=0.129N P=0.314N P=0.119N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 59
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Rathke's Cleft |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 1/95 (1%) 1/97 (1%) 0/100 (0%) |2/99 (2%) 0/99 (0%) 0/98 (0%) 2/98 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.3% 1.2% 0.0% |2.3% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/57 (0%) 0/45 (0%) 0/46 (0%) 0/48 (0%) |1/59 (2%) 0/67 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 602 694 --- |565 --- --- 409 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.513N P=0.484 P=0.500 (e) |P=0.304 P=0.221N P=0.237N P=0.691N |
|POLY 3 | P=0.505N P=0.484 P=0.492 (e) |P=0.301 P=0.231N P=0.237N P=0.688 |
|POLY 1.5 | P=0.500N P=0.488 P=0.494 (e) |P=0.302 P=0.234N P=0.239N P=0.683 |
|POLY 6 | P=0.510N P=0.481 P=0.490 (e) |P=0.303 P=0.227N P=0.234N P=0.687N |
|LOGISTIC REGRESSION| P=0.485N P=0.529 P=0.496 (e) |P=0.445 P=0.264N P=0.241N P=0.630N |
|COCH-ARM / FISHERS | P=0.492N P=0.492 P=0.497 (e) |P=0.311 P=0.249N P=0.251N P=0.686 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Preputial Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/99 (1%) 0/100 (0%) 2/99 (2%) | |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 0.0% 2.5% | |
|TERMINAL (d) | 0/57 (0%) 0/45 (0%) 0/47 (0%) 1/47 (2%) | |
|FIRST INCIDENCE | 729 631 --- 724 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.301 P=0.733 P=0.518N P=0.461 | |
|POLY 3 | P=0.302 P=0.747 P=0.505N P=0.476 | |
|POLY 1.5 | P=0.306 P=0.751 P=0.503N P=0.484 | |
|POLY 6 | P=0.298 P=0.743 P=0.507N P=0.469 | |
|LOGISTIC REGRESSION| P=0.301 P=0.762 P=0.506N P=0.468 | |
|COCH-ARM / FISHERS | P=0.311 P=0.749 P=0.500N P=0.496 | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 60
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 8/99 (8%) 2/100 (2%) 4/99 (4%) | |
|POLY-3 ADJUSTED (b)| 4.6% 10.0% 2.4% 5.0% | |
|TERMINAL (d) | 2/57 (4%) 7/45 (16%) 1/47 (2%) 2/47 (4%) | |
|FIRST INCIDENCE | 647 734 687 505 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.408N P=0.102 P=0.390N P=0.565 | |
|POLY 3 | P=0.392N P=0.152 P=0.353N P=0.605 | |
|POLY 1.5 | P=0.382N P=0.163 P=0.348N P=0.617 | |
|POLY 6 | P=0.401N P=0.139 P=0.357N P=0.593 | |
|LOGISTIC REGRESSION| P=0.392N P=0.141 P=0.347N P=0.630 | |
|COCH-ARM / FISHERS | P=0.368N P=0.181 P=0.341N P=0.634 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 80/100 (80%) 76/99 (77%) 76/100 (76%) 75/99 (76%) | |
|POLY-3 ADJUSTED (b)| 84.4% 82.3% 81.7% 80.5% | |
|TERMINAL (d) | 51/57 (90%) 35/45 (78%) 40/47 (85%) 35/47 (75%) | |
|FIRST INCIDENCE | 476 329 393 442 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.453 P=0.195 P=0.290 P=0.300 | |
|POLY 3 | P=0.325N P=0.423N P=0.374N P=0.298N | |
|POLY 1.5 | P=0.331N P=0.403N P=0.337N P=0.290N | |
|POLY 6 | P=0.329N P=0.412N P=0.419N P=0.300N | |
|LOGISTIC REGRESSION| P=0.450N P=0.504N P=0.385N P=0.401N | |
|COCH-ARM / FISHERS | P=0.365N P=0.351N P=0.304N P=0.291N | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 61
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Prostate |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 48/100 (48%) 57/99 (58%) 34/100 (34%) 47/99 (47%) | |
|POLY-3 ADJUSTED (b)| 52.8% 64.2% 38.8% 56.0% | |
|TERMINAL (d) | 30/57 (53%) 28/45 (62%) 15/47 (32%) 28/47 (60%) | |
|FIRST INCIDENCE | 581 267 557 461 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.519N P=0.024 * P=0.156N P=0.265 | |
|POLY 3 | P=0.540N P=0.072 P=0.038N* P=0.388 | |
|POLY 1.5 | P=0.464N P=0.086 P=0.034N* P=0.472 | |
|POLY 6 | P=0.464 P=0.061 P=0.043N* P=0.303 | |
|LOGISTIC REGRESSION| P=0.446N P=0.072 P=0.038N* P=0.411 | |
|COCH-ARM / FISHERS | P=0.367N P=0.113 P=0.031N* P=0.527N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 7/99 (7%) 15/100 (15%) 7/99 (7%) | |
|POLY-3 ADJUSTED (b)| 4.6% 8.6% 17.2% 8.4% | |
|TERMINAL (d) | 2/57 (4%) 2/45 (4%) 5/47 (11%) 1/47 (2%) | |
|FIRST INCIDENCE | 527 647 405 410 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.507 P=0.205 P=0.006 ** P=0.221 | |
|POLY 3 | P=0.534 P=0.230 P=0.007 ** P=0.242 | |
|POLY 1.5 | P=0.541 P=0.242 P=0.007 ** P=0.250 | |
|POLY 6 | P=0.531 P=0.221 P=0.007 ** P=0.237 | |
|LOGISTIC REGRESSION| P=0.559N P=0.272 P=0.009 ** P=0.367 | |
|COCH-ARM / FISHERS | P=0.547 P=0.263 P=0.007 ** P=0.263 | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 62
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/100 (42%) 51/99 (52%) 49/100 (49%) 41/99 (41%) | |
|POLY-3 ADJUSTED (b)| 45.8% 58.6% 53.7% 46.1% | |
|TERMINAL (d) | 20/57 (35%) 30/45 (67%) 27/47 (57%) 15/47 (32%) | |
|FIRST INCIDENCE | 476 329 393 477 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.339N P=0.030 * P=0.091 P=0.355 | |
|POLY 3 | P=0.188N P=0.053 P=0.174 P=0.543 | |
|POLY 1.5 | P=0.195N P=0.075 P=0.187 P=0.559N | |
|POLY 6 | P=0.163N P=0.031 * P=0.153 P=0.538 | |
|LOGISTIC REGRESSION| P=0.208N P=0.084 P=0.193 P=0.522N | |
|COCH-ARM / FISHERS | P=0.196N P=0.114 P=0.197 P=0.524N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Prostate: Epithelium |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/100 (10%) 7/99 (7%) 5/100 (5%) 9/99 (9%) | |
|POLY-3 ADJUSTED (b)| 11.6% 8.7% 5.9% 11.2% | |
|TERMINAL (d) | 9/57 (16%) 6/45 (13%) 4/47 (9%) 7/47 (15%) | |
|FIRST INCIDENCE | 701 612 496 697 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.382 P=0.483N P=0.227N P=0.539 | |
|POLY 3 | P=0.412 P=0.352N P=0.147N P=0.563N | |
|POLY 1.5 | P=0.424 P=0.338N P=0.145N P=0.542N | |
|POLY 6 | P=0.403 P=0.367N P=0.148N P=0.580N | |
|LOGISTIC REGRESSION| P=0.398 P=0.383N P=0.154N P=0.586N | |
|COCH-ARM / FISHERS | P=0.440 P=0.314N P=0.141N P=0.509N | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 63
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Salivary Glands: Parotid Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 2/99 (2%) 0/100 (0%) 2/100 (2%) |3/100 (3%) 2/99 (2%) 3/100 (3%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 0.0% 2.5% |3.5% 2.2% 3.4% 2.4% |
|TERMINAL (d) | 0/57 (0%) 2/46 (4%) 0/47 (0%) 2/48 (4%) |2/59 (3%) 0/68 (0%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | --- 736 (T) --- 736 (T) |553 631 681 696 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.293 P=0.193 (e) P=0.202 |P=0.503N P=0.453N P=0.641N P=0.487N |
|POLY 3 | P=0.299 P=0.228 (e) P=0.228 |P=0.519N P=0.482N P=0.651N P=0.505N |
|POLY 1.5 | P=0.305 P=0.232 (e) P=0.233 |P=0.517N P=0.492N P=0.656N P=0.509N |
|POLY 6 | P=0.293 P=0.223 (e) P=0.223 |P=0.515N P=0.468N P=0.643N P=0.493N |
|LOGISTIC REGRESSION| (e) P=0.193 (e) P=0.202 |P=0.487N P=0.553N P=0.659 P=0.503N |
|COCH-ARM / FISHERS | P=0.315 P=0.249 (e) P=0.251 |P=0.497N P=0.505N P=0.659N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 84/100 (84%) 79/99 (80%) 86/100 (86%) 78/99 (79%) | |
|POLY-3 ADJUSTED (b)| 87.9% 84.9% 89.2% 85.5% | |
|TERMINAL (d) | 49/57 (86%) 37/45 (82%) 41/47 (87%) 40/47 (85%) | |
|FIRST INCIDENCE | 549 267 393 442 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.516 P=0.223 P=0.127 P=0.320 | |
|POLY 3 | P=0.428N P=0.340N P=0.479 P=0.386N | |
|POLY 1.5 | P=0.338N P=0.300N P=0.471 P=0.298N | |
|POLY 6 | P=0.528N P=0.415N P=0.465 P=0.505N | |
|LOGISTIC REGRESSION| P=0.326N P=0.417N P=0.348 P=0.427N | |
|COCH-ARM / FISHERS | P=0.244N P=0.279N P=0.422 P=0.223N | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 64
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 4/100 (4%) 3/100 (3%) 3/100 (3%) |0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.9% 3.6% 3.7% |0.0% 0.0% 1.1% 0.0% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 2/47 (4%) 3/48 (6%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 639 586 736 (T) |--- --- 647 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.409 P=0.050 P=0.099 P=0.093 |P=0.763N (e) P=0.517 (e) |
|POLY 3 | P=0.411 P=0.059 P=0.119 P=0.113 |P=0.771N (e) P=0.505 (e) |
|POLY 1.5 | P=0.422 P=0.061 P=0.121 P=0.117 |P=0.771N (e) P=0.503 (e) |
|POLY 6 | P=0.401 P=0.057 P=0.118 P=0.109 |P=0.769N (e) P=0.509 (e) |
|LOGISTIC REGRESSION| P=0.423 P=0.061 P=0.124 P=0.093 |P=0.743N (e) P=0.501 (e) |
|COCH-ARM / FISHERS | P=0.440 P=0.062 P=0.125 P=0.125 |P=0.767N (e) P=0.500 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |1/100 (1%) 0/100 (0%) 2/100 (2%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 1.2% 0.0% |1.2% 0.0% 2.3% 1.2% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 2/60 (3%) 1/61 (2%) |
|FIRST INCIDENCE | --- --- 736 (T) --- |737 (T) --- 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.775N (e) P=0.462 (e) |P=0.587 P=0.472N P=0.506 P=0.754N |
|POLY 3 | P=0.771N (e) P=0.497 (e) |P=0.582 P=0.491N P=0.508 P=0.759 |
|POLY 1.5 | P=0.769N (e) P=0.499 (e) |P=0.582 P=0.495N P=0.504 P=0.757 |
|POLY 6 | P=0.772N (e) P=0.495 (e) |P=0.586 P=0.486N P=0.514 P=0.756N |
|LOGISTIC REGRESSION| (e) (e) P=0.462 (e) |P=0.587 (e) P=0.506 P=0.754N |
|COCH-ARM / FISHERS | P=0.766N (e) P=0.503 (e) |P=0.597 P=0.500N P=0.500 P=0.751N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 65
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin: Dermis |
| Fibrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 2/100 (2%) 1/100 (1%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 1.2% 0.0% |0.0% 0.0% 0.0% 1.2% |
|TERMINAL (d) | 0/57 (0%) 2/46 (4%) 1/47 (2%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 736 (T) 736 (T) --- |--- --- --- 735 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.352N P=0.193 P=0.462 (e) |P=0.234 (e) (e) P=0.510 |
|POLY 3 | P=0.353N P=0.229 P=0.497 (e) |P=0.229 (e) (e) P=0.499 |
|POLY 1.5 | P=0.346N P=0.233 P=0.499 (e) |P=0.229 (e) (e) P=0.496 |
|POLY 6 | P=0.358N P=0.224 P=0.495 (e) |P=0.231 (e) (e) P=0.505 |
|LOGISTIC REGRESSION| (e) P=0.193 P=0.462 (e) |P=0.236 (e) (e) P=0.514 |
|COCH-ARM / FISHERS | P=0.337N P=0.251 P=0.503 (e) |P=0.233 (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 3/100 (3%) 5/100 (5%) 1/100 (1%) |0/100 (0%) 1/100 (1%) 1/100 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.7% 5.9% 1.2% |0.0% 1.1% 1.1% 0.0% |
|TERMINAL (d) | 0/57 (0%) 2/46 (4%) 3/47 (6%) 1/48 (2%) |0/59 (0%) 1/68 (2%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 729 583 736 (T) |--- 737 (T) 508 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.429N P=0.093 P=0.026 * P=0.466 |P=0.512N P=0.528 P=0.496 (e) |
|POLY 3 | P=0.429N P=0.112 P=0.032 * P=0.489 |P=0.503N P=0.509 P=0.506 (e) |
|POLY 1.5 | P=0.419N P=0.116 P=0.033 * P=0.493 |P=0.506N P=0.505 P=0.503 (e) |
|POLY 6 | P=0.438N P=0.109 P=0.032 * P=0.485 |P=0.497N P=0.514 P=0.510 (e) |
|LOGISTIC REGRESSION| P=0.419N P=0.104 P=0.035 * P=0.466 |P=0.418N P=0.528 P=0.609 (e) |
|COCH-ARM / FISHERS | P=0.403N P=0.123 P=0.030 * P=0.500 |P=0.501N P=0.500 P=0.500 (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 66
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 6/100 (6%) 4/100 (4%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 7.3% 4.8% 1.2% |0.0% 0.0% 1.1% 0.0% |
|TERMINAL (d) | 1/57 (2%) 2/46 (4%) 3/47 (6%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) 624 701 736 (T) |--- --- 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.182N P=0.042 * P=0.139 P=0.723 |P=0.771N (e) P=0.503 (e) |
|POLY 3 | P=0.178N P=0.053 P=0.175 P=0.748 |P=0.771N (e) P=0.505 (e) |
|POLY 1.5 | P=0.171N P=0.056 P=0.178 P=0.753 |P=0.771N (e) P=0.502 (e) |
|POLY 6 | P=0.184N P=0.051 P=0.173 P=0.744 |P=0.769N (e) P=0.508 (e) |
|LOGISTIC REGRESSION| P=0.171N P=0.054 P=0.172 P=0.723 |(e) (e) P=0.503 (e) |
|COCH-ARM / FISHERS | P=0.161N P=0.059 P=0.184 P=0.751N |P=0.767N (e) P=0.500 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/100 (14%) 12/100 (12%) 13/100 (13%) 15/100 (15%)|15/100 (15%) 15/100 (15%) 20/100 (20%) 13/100 (13%) |
|POLY-3 ADJUSTED (b)| 16.0% 13.9% 15.0% 17.5% |16.8% 16.5% 22.5% 14.7% |
|TERMINAL (d) | 7/57 (12%) 1/46 (2%) 3/47 (6%) 7/48 (15%) |5/59 (9%) 10/68 (15%) 14/60 (23%) 6/61 (10%) |
|FIRST INCIDENCE | 583 329 477 442 |462 589 557 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.319 P=0.529N P=0.562 P=0.373 |P=0.349N P=0.465N P=0.266 P=0.409N |
|POLY 3 | P=0.341 P=0.431N P=0.508N P=0.474 |P=0.334N P=0.555N P=0.220 P=0.431N |
|POLY 1.5 | P=0.350 P=0.425N P=0.505N P=0.485 |P=0.338N P=0.565N P=0.222 P=0.439N |
|POLY 6 | P=0.334 P=0.439N P=0.508N P=0.464 |P=0.319N P=0.541N P=0.219 P=0.413N |
|LOGISTIC REGRESSION| P=0.410 P=0.335N P=0.488N P=0.551 |P=0.264N P=0.509 P=0.223 P=0.340N |
|COCH-ARM / FISHERS | P=0.362 P=0.417N P=0.500N P=0.500 |P=0.308N P=0.578N P=0.229 P=0.419N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 67
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 11/100 (11%) 17/100 (17%) 15/100 (15%)|54/100 (54%) 48/100 (48%) 56/100 (56%) 57/100 (57%) |
|POLY-3 ADJUSTED (b)| 13.7% 13.1% 19.6% 17.8% |58.5% 50.9% 59.3% 59.8% |
|TERMINAL (d) | 7/57 (12%) 6/46 (13%) 8/47 (17%) 7/48 (15%) |36/59 (61%) 32/68 (47%) 35/60 (58%) 37/61 (61%) |
|FIRST INCIDENCE | 476 329 393 494 |494 508 429 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.252 P=0.525 P=0.137 P=0.234 |P=0.184 P=0.087N P=0.520 P=0.460 |
|POLY 3 | P=0.268 P=0.543N P=0.195 P=0.293 |P=0.252 P=0.180N P=0.517 P=0.485 |
|POLY 1.5 | P=0.279 P=0.526N P=0.201 P=0.310 |P=0.230 P=0.204N P=0.483 P=0.437 |
|POLY 6 | P=0.263 P=0.563N P=0.191 P=0.281 |P=0.286 P=0.150N P=0.562N P=0.551 |
|LOGISTIC REGRESSION| P=0.315 P=0.450N P=0.219 P=0.358 |P=0.233 P=0.220N P=0.450 P=0.408 |
|COCH-ARM / FISHERS | P=0.299 P=0.500N P=0.211 P=0.340 |P=0.212 P=0.240N P=0.444 P=0.388 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen: Capsule |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 3/100 (3%) 1/100 (1%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.6% 1.2% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- 526 736 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.247N P=0.117 P=0.462 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.248N P=0.115 P=0.495 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.242N P=0.117 P=0.497 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.252N P=0.113 P=0.494 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.226N P=0.149 P=0.462 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.234N P=0.123 P=0.500 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 68
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 4/100 (4%) 3/100 (3%) 3/100 (3%) |6/100 (6%) 3/100 (3%) 3/100 (3%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 1.2% 4.8% 3.6% 3.6% |6.8% 3.3% 3.4% 4.7% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 725 267 489 461 |543 582 617 557 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.514 P=0.168 P=0.297 P=0.293 |P=0.565N P=0.217N P=0.229N P=0.370N |
|POLY 3 | P=0.512 P=0.173 P=0.301 P=0.294 |P=0.573N P=0.237N P=0.246N P=0.389N |
|POLY 1.5 | P=0.518 P=0.177 P=0.303 P=0.299 |P=0.571N P=0.242N P=0.248N P=0.391N |
|POLY 6 | P=0.508 P=0.169 P=0.301 P=0.291 |P=0.568N P=0.232N P=0.243N P=0.379N |
|LOGISTIC REGRESSION| P=0.557 P=0.249 P=0.318 P=0.366 |P=0.410N P=0.347N P=0.231N P=0.294N |
|COCH-ARM / FISHERS | P=0.529 P=0.184 P=0.311 P=0.311 |P=0.549N P=0.249N P=0.249N P=0.374N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 3/100 (3%) 5/100 (5%) 3/100 (3%) |3/100 (3%) 0/99 (0%) 1/99 (1%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 3.5% 3.7% 5.9% 3.6% |3.5% 0.0% 1.2% 3.5% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 2/61 (3%) |
|FIRST INCIDENCE | 674 631 604 505 |495 --- 728 696 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.575N P=0.617 P=0.353 P=0.623 |P=0.258 P=0.112N P=0.298N P=0.643N |
|POLY 3 | P=0.567N P=0.639 P=0.348 P=0.641 |P=0.246 P=0.117N P=0.308N P=0.652 |
|POLY 1.5 | P=0.561N P=0.646 P=0.352 P=0.648 |P=0.248 P=0.120N P=0.310N P=0.649 |
|POLY 6 | P=0.571N P=0.631 P=0.347 P=0.635 |P=0.247 P=0.114N P=0.305N P=0.659N |
|LOGISTIC REGRESSION| P=0.537N P=0.656N P=0.359 P=0.616N |P=0.287 P=0.170N P=0.303N P=0.644N |
|COCH-ARM / FISHERS | P=0.552N P=0.659N P=0.360 P=0.659N |P=0.262 P=0.125N P=0.314N P=0.659N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 69
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 2/100 (2%) 4/100 (4%) 4/100 (4%) |1/100 (1%) 1/99 (1%) 1/99 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 3.5% 2.5% 4.7% 4.9% |1.2% 1.1% 1.2% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | 527 685 393 516 |598 674 737 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.348 P=0.531N P=0.473 P=0.460 |P=0.343N P=0.746N P=0.754N P=0.507N |
|POLY 3 | P=0.351 P=0.528N P=0.489 P=0.469 |P=0.344N P=0.753N P=0.759N P=0.502N |
|POLY 1.5 | P=0.358 P=0.518N P=0.494 P=0.481 |P=0.344N P=0.757N P=0.760 P=0.504N |
|POLY 6 | P=0.347 P=0.540N P=0.484 P=0.459 |P=0.341N P=0.747N P=0.756N P=0.497N |
|LOGISTIC REGRESSION| P=0.391 P=0.465N P=0.542 P=0.554 |P=0.312N P=0.721 P=0.758 P=0.451N |
|COCH-ARM / FISHERS | P=0.367 P=0.500N P=0.500 P=0.500 |P=0.335N P=0.749 P=0.749 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/100 (2%) 2/100 (2%) 3/100 (3%) |3/100 (3%) 1/99 (1%) 0/99 (0%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 1.2% 2.5% 2.4% 3.7% |3.5% 1.1% 0.0% 3.5% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 647 706 561 664 |553 632 --- 673 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.290 P=0.472 P=0.473 P=0.278 |P=0.320 P=0.283N P=0.115N P=0.644N |
|POLY 3 | P=0.286 P=0.481 P=0.492 P=0.287 |P=0.310 P=0.297N P=0.122N P=0.653 |
|POLY 1.5 | P=0.292 P=0.488 P=0.495 P=0.295 |P=0.311 P=0.303N P=0.123N P=0.650 |
|POLY 6 | P=0.281 P=0.474 P=0.490 P=0.280 |P=0.312 P=0.290N P=0.120N P=0.658N |
|LOGISTIC REGRESSION| P=0.298 P=0.493 P=0.515 P=0.298 |P=0.381 P=0.393N P=0.111N P=0.643N |
|COCH-ARM / FISHERS | P=0.301 P=0.500 P=0.500 P=0.311 |P=0.325 P=0.314N P=0.125N P=0.659N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 70
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 5/100 (5%) 9/100 (9%) 2/100 (2%) |7/100 (7%) 2/99 (2%) 0/99 (0%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 6.9% 6.0% 10.5% 2.5% |7.9% 2.3% 0.0% 3.5% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |0/59 (0%) 1/68 (2%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 527 526 393 704 |553 674 --- 522 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.120N P=0.560N P=0.269 P=0.177N |P=0.459N P=0.075N P=0.010N* P=0.171N |
|POLY 3 | P=0.118N P=0.536N P=0.285 P=0.163N |P=0.455N P=0.084N P=0.010N* P=0.176N |
|POLY 1.5 | P=0.110N P=0.523N P=0.290 P=0.153N |P=0.454N P=0.086N P=0.010N* P=0.177N |
|POLY 6 | P=0.126N P=0.550N P=0.281 P=0.173N |P=0.450N P=0.082N P=0.010N* P=0.170N |
|LOGISTIC REGRESSION| P=0.092N P=0.458N P=0.325 P=0.132N |P=0.272N P=0.141N P=0.007N** P=0.093N |
|COCH-ARM / FISHERS | P=0.101N P=0.500N P=0.296 P=0.140N |P=0.440N P=0.087N P=0.007N** P=0.166N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/99 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 3.5% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 649 --- --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.248N P=0.153N P=0.144N P=0.145N |(e) (e) (e) (e) |
|POLY 3 | P=0.232N P=0.132N P=0.127N P=0.132N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.235N P=0.128N P=0.125N P=0.128N |(e) (e) (e) (e) |
|POLY 6 | P=0.230N P=0.136N P=0.128N P=0.136N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.245N P=0.130N P=0.126N P=0.131N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.240N P=0.123N P=0.123N P=0.123N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 71
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 1/99 (1%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 1.2% 0.0% |0.0% 0.0% 1.2% 1.2% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 701 --- 718 --- |--- --- 728 673 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.345N P=0.269N P=0.517N P=0.264N |P=0.370 (e) P=0.506 P=0.511 |
|POLY 3 | P=0.335N P=0.251N P=0.509N P=0.251N |P=0.358 (e) P=0.502 P=0.499 |
|POLY 1.5 | P=0.335N P=0.246N P=0.506N P=0.246N |P=0.357 (e) P=0.500 P=0.497 |
|POLY 6 | P=0.335N P=0.255N P=0.512N P=0.256N |P=0.364 (e) P=0.506 P=0.506 |
|LOGISTIC REGRESSION| P=0.345N P=0.255N P=0.511N P=0.255N |P=0.363 (e) P=0.507 P=0.504 |
|COCH-ARM / FISHERS | P=0.336N P=0.249N P=0.500N P=0.249N |P=0.366 (e) P=0.497 P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/100 (9%) 3/100 (3%) 9/100 (9%) 8/100 (8%) |5/100 (5%) 2/100 (2%) 2/99 (2%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 10.2% 3.6% 10.5% 9.6% |5.7% 2.2% 2.3% 5.8% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 2/61 (3%) |
|FIRST INCIDENCE | 527 581 539 461 |553 611 681 579 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.348 P=0.097N P=0.570 P=0.560N |P=0.294 P=0.200N P=0.209N P=0.612N |
|POLY 3 | P=0.354 P=0.082N P=0.574 P=0.550N |P=0.280 P=0.209N P=0.224N P=0.615 |
|POLY 1.5 | P=0.363 P=0.076N P=0.583 P=0.530N |P=0.282 P=0.214N P=0.225N P=0.611 |
|POLY 6 | P=0.348 P=0.089N P=0.566 P=0.570N |P=0.284 P=0.202N P=0.221N P=0.627N |
|LOGISTIC REGRESSION| P=0.398 P=0.048N* P=0.575N P=0.451N |P=0.382 P=0.313N P=0.218N P=0.585N |
|COCH-ARM / FISHERS | P=0.373 P=0.067N P=0.597N P=0.500N |P=0.300 P=0.222N P=0.227N P=0.626N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 72
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Stomach, Glandular: Glands |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 6/100 (6%) 1/100 (1%) 3/100 (3%) |12/100 (12%) 20/100 (20%) 26/99 (26%) 12/100 (12%) |
|POLY-3 ADJUSTED (b)| 4.7% 7.4% 1.2% 3.7% |13.8% 22.2% 29.8% 13.8% |
|TERMINAL (d) | 2/57 (4%) 5/46 (11%) 1/47 (2%) 0/48 (0%) |7/59 (12%) 16/68 (24%) 22/60 (37%) 8/61 (13%) |
|FIRST INCIDENCE | 690 670 736 (T) 664 |597 632 656 485 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.375N P=0.273 P=0.218N P=0.545N |P=0.164N P=0.172 P=0.013 * P=0.563N |
|POLY 3 | P=0.364N P=0.340 P=0.190N P=0.529N |P=0.147N P=0.102 P=0.007 ** P=0.584 |
|POLY 1.5 | P=0.357N P=0.353 P=0.187N P=0.518N |P=0.155N P=0.096 P=0.007 ** P=0.571 |
|POLY 6 | P=0.368N P=0.328 P=0.193N P=0.538N |P=0.129N P=0.111 P=0.007 ** P=0.565N |
|LOGISTIC REGRESSION| P=0.368N P=0.324 P=0.191N P=0.531N |P=0.158N P=0.110 P=0.011 * P=0.584 |
|COCH-ARM / FISHERS | P=0.347N P=0.374 P=0.184N P=0.500N |P=0.138N P=0.088 P=0.008 ** P=0.586N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Testes |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 1/100 (1%) 4/100 (4%) 0/100 (0%) | |
|POLY-3 ADJUSTED (b)| 3.5% 1.2% 4.8% 0.0% | |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 1/47 (2%) 0/48 (0%) | |
|FIRST INCIDENCE | 647 267 604 --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.159N P=0.349N P=0.457 P=0.144N | |
|POLY 3 | P=0.158N P=0.324N P=0.486 P=0.133N | |
|POLY 1.5 | P=0.154N P=0.317N P=0.491 P=0.128N | |
|POLY 6 | P=0.161N P=0.333N P=0.482 P=0.138N | |
|LOGISTIC REGRESSION| P=0.140N P=0.221N P=0.500 P=0.119N | |
|COCH-ARM / FISHERS | P=0.149N P=0.311N P=0.500 P=0.123N | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 73
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/100 (10%) 14/100 (14%) 14/100 (14%) 12/100 (12%)| |
|POLY-3 ADJUSTED (b)| 11.6% 16.7% 16.5% 14.4% | |
|TERMINAL (d) | 8/57 (14%) 6/46 (13%) 6/47 (13%) 7/48 (15%) | |
|FIRST INCIDENCE | 647 267 405 461 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.530 P=0.150 P=0.170 P=0.286 | |
|POLY 3 | P=0.557N P=0.228 P=0.240 P=0.377 | |
|POLY 1.5 | P=0.547N P=0.239 P=0.247 P=0.390 | |
|POLY 6 | P=0.554 P=0.219 P=0.236 P=0.367 | |
|LOGISTIC REGRESSION| P=0.541N P=0.239 P=0.236 P=0.394 | |
|COCH-ARM / FISHERS | P=0.530N P=0.257 P=0.257 P=0.411 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/100 (11%) 9/100 (9%) 17/100 (17%) 22/100 (22%)| |
|POLY-3 ADJUSTED (b)| 12.5% 10.7% 18.9% 24.8% | |
|TERMINAL (d) | 6/57 (11%) 3/46 (7%) 3/47 (6%) 7/48 (15%) | |
|FIRST INCIDENCE | 502 466 393 442 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.006 ** P=0.524N P=0.119 P=0.018 * | |
|POLY 3 | P=0.007 ** P=0.449N P=0.167 P=0.027 * | |
|POLY 1.5 | P=0.007 ** P=0.434N P=0.162 P=0.027 * | |
|POLY 6 | P=0.008 ** P=0.466N P=0.176 P=0.029 * | |
|LOGISTIC REGRESSION| P=0.009 ** P=0.361N P=0.194 P=0.053 | |
|COCH-ARM / FISHERS | P=0.006 ** P=0.407N P=0.154 P=0.028 * | |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 74
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 58/97 (60%) 46/94 (49%) 63/95 (66%) 62/90 (69%) |51/95 (54%) 48/95 (51%) 47/92 (51%) 48/91 (53%) |
|POLY-3 ADJUSTED (b)| 65.2% 54.1% 69.8% 73.2% |57.1% 52.9% 53.1% 56.9% |
|TERMINAL (d) | 39/55 (71%) 25/44 (57%) 30/45 (67%) 36/46 (78%) |28/56 (50%) 29/64 (45%) 27/57 (47%) 29/56 (52%) |
|FIRST INCIDENCE | 406 267 393 442 |462 508 488 394 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.059 P=0.372N P=0.085 P=0.076 |P=0.480 P=0.195N P=0.302N P=0.397N |
|POLY 3 | P=0.026 * P=0.083N P=0.303 P=0.152 |P=0.404 P=0.339N P=0.353N P=0.555N |
|POLY 1.5 | P=0.022 * P=0.082N P=0.264 P=0.138 |P=0.401 P=0.360N P=0.382N P=0.551 |
|POLY 6 | P=0.034 * P=0.084N P=0.363 P=0.182 |P=0.426 P=0.311N P=0.319N P=0.517N |
|LOGISTIC REGRESSION| P=0.020 * P=0.110N P=0.196 P=0.095 |P=0.519 P=0.431N P=0.462N P=0.512N |
|COCH-ARM / FISHERS | P=0.021 * P=0.087N P=0.216 P=0.126 |P=0.490 P=0.386N P=0.417N P=0.508N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thymus |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/97 (1%) 2/94 (2%) 1/95 (1%) 0/90 (0%) |1/95 (1%) 3/95 (3%) 5/92 (5%) 2/91 (2%) |
|POLY-3 ADJUSTED (b)| 1.2% 2.6% 1.3% 0.0% |1.2% 3.5% 6.2% 2.6% |
|TERMINAL (d) | 1/55 (2%) 2/44 (5%) 1/45 (2%) 0/46 (0%) |0/56 (0%) 2/64 (3%) 4/57 (7%) 1/56 (2%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) --- |736 590 723 702 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.247N P=0.422 P=0.716 P=0.536N |P=0.554N P=0.344 P=0.113 P=0.514 |
|POLY 3 | P=0.254N P=0.471 P=0.750 P=0.525N |P=0.566N P=0.327 P=0.106 P=0.485 |
|POLY 1.5 | P=0.251N P=0.478 P=0.752 P=0.521N |P=0.570N P=0.318 P=0.102 P=0.479 |
|POLY 6 | P=0.256N P=0.464 P=0.748 P=0.527N |P=0.552N P=0.337 P=0.111 P=0.497 |
|LOGISTIC REGRESSION| P=0.247N P=0.422 P=0.716 (e) |P=0.562N P=0.307 P=0.112 P=0.499 |
|COCH-ARM / FISHERS | P=0.245N P=0.488 P=0.746 P=0.519N |P=0.552N P=0.310 P=0.098 P=0.484 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 75
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thymus |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/97 (2%) 3/94 (3%) 2/95 (2%) 2/90 (2%) |2/95 (2%) 1/95 (1%) 3/92 (3%) 6/91 (7%) |
|POLY-3 ADJUSTED (b)| 2.4% 3.8% 2.5% 2.7% |2.4% 1.2% 3.6% 7.3% |
|TERMINAL (d) | 0/55 (0%) 1/44 (2%) 0/45 (0%) 0/46 (0%) |0/56 (0%) 0/64 (0%) 0/57 (0%) 0/56 (0%) |
|FIRST INCIDENCE | 695 267 405 410 |494 563 358 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.545N P=0.464 P=0.689 P=0.677 |P=0.031 * P=0.481N P=0.510 P=0.141 |
|POLY 3 | P=0.576N P=0.470 P=0.681 P=0.651 |P=0.029 * P=0.484N P=0.505 P=0.139 |
|POLY 1.5 | P=0.571N P=0.477 P=0.683 P=0.657 |P=0.028 * P=0.491N P=0.497 P=0.131 |
|POLY 6 | P=0.578N P=0.461 P=0.679 P=0.648 |P=0.031 * P=0.476N P=0.516 P=0.152 |
|LOGISTIC REGRESSION| P=0.531N P=0.565 P=0.680N P=0.677N |P=0.575 P=0.647N P=0.504 P=0.588 |
|COCH-ARM / FISHERS | P=0.563N P=0.485 P=0.682 P=0.661 |P=0.028 * P=0.500N P=0.485 P=0.126 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thymus: Epithelial Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/97 (2%) 3/94 (3%) 3/95 (3%) 6/90 (7%) |3/95 (3%) 1/95 (1%) 3/92 (3%) 4/91 (4%) |
|POLY-3 ADJUSTED (b)| 2.4% 3.8% 3.7% 8.2% |3.7% 1.2% 3.7% 5.2% |
|TERMINAL (d) | 1/55 (2%) 0/44 (0%) 1/45 (2%) 6/46 (13%) |2/56 (4%) 1/64 (2%) 3/57 (5%) 3/56 (5%) |
|FIRST INCIDENCE | 725 505 617 736 (T) |602 737 (T) 737 (T) 702 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.079 P=0.454 P=0.451 P=0.091 |P=0.228 P=0.271N P=0.650N P=0.505 |
|POLY 3 | P=0.066 P=0.472 P=0.482 P=0.101 |P=0.218 P=0.291N P=0.659 P=0.474 |
|POLY 1.5 | P=0.070 P=0.477 P=0.485 P=0.106 |P=0.218 P=0.298N P=0.653 P=0.467 |
|POLY 6 | P=0.064 P=0.468 P=0.481 P=0.097 |P=0.224 P=0.283N P=0.655N P=0.490 |
|LOGISTIC REGRESSION| P=0.076 P=0.540 P=0.492 P=0.105 |P=0.227 P=0.300N P=0.659N P=0.478 |
|COCH-ARM / FISHERS | P=0.076 P=0.485 P=0.490 P=0.116 |P=0.234 P=0.310N P=0.643 P=0.476 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 76
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/100 (0%) 0/100 (0%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 0.0% 2.5% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 627 --- --- 673 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.299 P=0.278N P=0.269N P=0.655 |(e) (e) (e) (e) |
|POLY 3 | P=0.315 P=0.249N P=0.243N P=0.676 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.315 P=0.244N P=0.240N P=0.684 |(e) (e) (e) (e) |
|POLY 6 | P=0.316 P=0.255N P=0.246N P=0.669 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.316 P=0.234N P=0.234N P=0.687N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.315 P=0.246N P=0.246N P=0.686N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Ultimobranchial Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/100 (1%) 4/100 (4%) 7/100 (7%) |2/100 (2%) 4/100 (4%) 7/100 (7%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% 4.7% 8.6% |2.3% 4.5% 8.0% 3.5% |
|TERMINAL (d) | 0/57 (0%) 1/46 (2%) 1/47 (2%) 6/48 (13%) |2/59 (3%) 3/68 (4%) 6/60 (10%) 1/61 (2%) |
|FIRST INCIDENCE | 701 736 (T) 393 461 |737 (T) 672 652 522 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.007 ** P=0.731 P=0.171 P=0.023 * |P=0.521N P=0.402 P=0.091 P=0.498 |
|POLY 3 | P=0.007 ** P=0.750 P=0.181 P=0.029 * |P=0.509N P=0.361 P=0.091 P=0.504 |
|POLY 1.5 | P=0.008 ** P=0.755 P=0.183 P=0.032 * |P=0.516N P=0.352 P=0.088 P=0.496 |
|POLY 6 | P=0.007 ** P=0.745 P=0.179 P=0.027 * |P=0.491N P=0.375 P=0.096 P=0.520 |
|LOGISTIC REGRESSION| P=0.009 ** P=0.747 P=0.200 P=0.032 * |P=0.511N P=0.378 P=0.097 P=0.530 |
|COCH-ARM / FISHERS | P=0.009 ** P=0.749N P=0.187 P=0.033 * |P=0.500N P=0.341 P=0.085 P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 77
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/100 (1%) 3/100 (3%) 1/100 (1%) |18/100 (18%) 0/100 (0%) 0/100 (0%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% 3.6% 1.2% |20.7% 0.0% 0.0% 5.9% |
|TERMINAL (d) | 0/57 (0%) 0/46 (0%) 2/47 (4%) 0/48 (0%) |13/59 (22%) 0/68 (0%) 0/60 (0%) 3/61 (5%) |
|FIRST INCIDENCE | --- 680 621 613 |598 --- --- 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.608 P=0.494 P=0.098 P=0.476 |P=0.230N P<0.001N** P<0.001N** P=0.003N** |
|POLY 3 | P=0.613 P=0.492 P=0.119 P=0.491 |P=0.231N P<0.001N** P<0.001N** P=0.004N** |
|POLY 1.5 | P=0.620 P=0.495 P=0.121 P=0.495 |P=0.226N P<0.001N** P<0.001N** P=0.004N** |
|POLY 6 | P=0.609 P=0.488 P=0.118 P=0.488 |P=0.231N P<0.001N** P<0.001N** P=0.003N** |
|LOGISTIC REGRESSION| P=0.632 P=0.504 P=0.122 P=0.528 |P=0.227N P<0.001N** P<0.001N** P=0.003N** |
|COCH-ARM / FISHERS | P=0.630 P=0.503 P=0.125 P=0.503 |P=0.215N P<0.001N** P<0.001N** P=0.003N** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/99 (4%) 0/100 (0%) 0/100 (0%) 1/100 (1%) |2/100 (2%) 1/100 (1%) 0/100 (0%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 4.7% 0.0% 0.0% 1.2% |2.3% 1.1% 0.0% 3.5% |
|TERMINAL (d) | 3/57 (5%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 0/60 (0%) 3/61 (5%) |
|FIRST INCIDENCE | 661 --- --- 662 |655 631 --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.468N P=0.091N P=0.086N P=0.220N |P=0.206 P=0.461N P=0.232N P=0.515 |
|POLY 3 | P=0.446N P=0.070N P=0.066N P=0.197N |P=0.202 P=0.484N P=0.234N P=0.496 |
|POLY 1.5 | P=0.449N P=0.067N P=0.065N P=0.190N |P=0.203 P=0.491N P=0.236N P=0.491 |
|POLY 6 | P=0.443N P=0.073N P=0.067N P=0.203N |P=0.203 P=0.475N P=0.231N P=0.507 |
|LOGISTIC REGRESSION| P=0.465N P=0.073N P=0.068N P=0.195N |P=0.205 P=0.525N P=0.238N P=0.508 |
|COCH-ARM / FISHERS | P=0.454N P=0.059N P=0.059N P=0.181N |P=0.212 P=0.500N P=0.249N P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 78
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/99 (29%) 22/100 (22%) 24/100 (24%) 24/100 (24%)|20/100 (20%) 39/100 (39%) 52/100 (52%) 24/100 (24%) |
|POLY-3 ADJUSTED (b)| 33.4% 26.8% 28.1% 28.6% |23.1% 42.9% 57.4% 27.7% |
|TERMINAL (d) | 23/57 (40%) 17/46 (37%) 14/47 (30%) 16/48 (33%) |15/59 (25%) 34/68 (50%) 36/60 (60%) 17/61 (28%) |
|FIRST INCIDENCE | 579 602 557 505 |553 563 617 557 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.543N P=0.419N P=0.492N P=0.491N |P=0.097N P=0.013 * P<0.001 ** P=0.357 |
|POLY 3 | P=0.449N P=0.215N P=0.273N P=0.299N |P=0.077N P=0.003 ** P<0.001 ** P=0.297 |
|POLY 1.5 | P=0.444N P=0.190N P=0.262N P=0.278N |P=0.086N P=0.003 ** P<0.001 ** P=0.281 |
|POLY 6 | P=0.446N P=0.247N P=0.281N P=0.315N |P=0.056N P=0.004 ** P<0.001 ** P=0.339 |
|LOGISTIC REGRESSION| P=0.511N P=0.243N P=0.291N P=0.336N |P=0.083N P=0.005 ** P<0.001 ** P=0.308 |
|COCH-ARM / FISHERS | P=0.435N P=0.155N P=0.247N P=0.247N |P=0.072N P=0.003 ** P<0.001 ** P=0.304 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 2/100 (2%) 5/100 (5%) 2/100 (2%) |1/100 (1%) 0/100 (0%) 1/100 (1%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 3.5% 2.5% 5.9% 2.5% |1.2% 0.0% 1.1% 1.2% |
|TERMINAL (d) | 3/57 (5%) 1/46 (2%) 2/47 (4%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | 736 (T) 670 583 662 |737 (T) --- 737 (T) 579 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.468N P=0.583N P=0.294 P=0.553N |P=0.544 P=0.472N P=0.757N P=0.759 |
|POLY 3 | P=0.457N P=0.519N P=0.355 P=0.520N |P=0.545 P=0.491N P=0.755N P=0.760N |
|POLY 1.5 | P=0.450N P=0.510N P=0.358 P=0.510N |P=0.545 P=0.495N P=0.758N P=0.757 |
|POLY 6 | P=0.461N P=0.527N P=0.354 P=0.527N |P=0.549 P=0.486N P=0.752N P=0.753N |
|LOGISTIC REGRESSION| P=0.454N P=0.534N P=0.352 P=0.527N |P=0.565 (e) P=0.757N P=0.752N |
|COCH-ARM / FISHERS | P=0.440N P=0.495N P=0.366 P=0.495N |P=0.557 P=0.500N P=0.751N P=0.751N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 79
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/100 (0%) 2/100 (2%) 1/100 (1%) |1/100 (1%) 0/100 (0%) 0/100 (0%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 1.2% 0.0% 2.4% 1.2% |1.2% 0.0% 0.0% 1.2% |
|TERMINAL (d) | 1/57 (2%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 736 (T) --- 489 733 |737 (T) --- --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.582 P=0.543N P=0.475 P=0.724 |P=0.493 P=0.472N P=0.497N P=0.754N |
|POLY 3 | P=0.589 P=0.509N P=0.497 P=0.750 |P=0.489 P=0.491N P=0.495N P=0.759 |
|POLY 1.5 | P=0.593 P=0.505N P=0.500 P=0.755 |P=0.491 P=0.495N P=0.498N P=0.757 |
|POLY 6 | P=0.586 P=0.513N P=0.496 P=0.745 |P=0.490 P=0.486N P=0.492N P=0.756N |
|LOGISTIC REGRESSION| P=0.605 (e) P=0.520 P=0.744 |P=0.493 (e) (e) P=0.754N |
|COCH-ARM / FISHERS | P=0.599 P=0.497N P=0.504 P=0.749N |P=0.501 P=0.500N P=0.500N P=0.751N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Trachea |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/100 (11%) 13/100 (13%) 15/100 (15%) 3/100 (3%) |6/100 (6%) 1/100 (1%) 8/100 (8%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 12.7% 15.9% 17.8% 3.7% |7.0% 1.1% 9.1% 8.2% |
|TERMINAL (d) | 8/57 (14%) 10/46 (22%) 10/47 (21%) 3/48 (6%) |4/59 (7%) 0/68 (0%) 6/60 (10%) 5/61 (8%) |
|FIRST INCIDENCE | 617 670 652 736 (T) |646 727 694 667 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010N* P=0.246 P=0.154 P=0.050N |P=0.192 P=0.046N* P=0.413 P=0.532 |
|POLY 3 | P=0.009N** P=0.355 P=0.234 P=0.033N* |P=0.175 P=0.054N P=0.404 P=0.493 |
|POLY 1.5 | P=0.008N** P=0.377 P=0.246 P=0.029N* |P=0.176 P=0.057N P=0.397 P=0.486 |
|POLY 6 | P=0.009N** P=0.331 P=0.224 P=0.036N* |P=0.180 P=0.051N P=0.414 P=0.513 |
|LOGISTIC REGRESSION| P=0.008N** P=0.334 P=0.233 P=0.035N* |P=0.190 P=0.054N P=0.421 P=0.509 |
|COCH-ARM / FISHERS | P=0.007N** P=0.414 P=0.264 P=0.024N* |P=0.198 P=0.059N P=0.391 P=0.500 |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 80
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/96 (0%) 1/100 (1%) 0/100 (0%) |1/99 (1%) 0/97 (0%) 0/99 (0%) 1/99 (1%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 1.2% 0.0% |1.2% 0.0% 0.0% 1.2% |
|TERMINAL (d) | 1/57 (2%) 0/44 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/67 (0%) 0/60 (0%) 1/61 (2%) |
|FIRST INCIDENCE | 527 --- 729 --- |674 --- --- 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.348N P=0.273N P=0.537N P=0.270N |P=0.497 P=0.479N P=0.484N P=0.751N |
|POLY 3 | P=0.329N P=0.260N P=0.508N P=0.251N |P=0.491 P=0.496N P=0.496N P=0.758 |
|POLY 1.5 | P=0.329N P=0.255N P=0.503N P=0.245N |P=0.493 P=0.499N P=0.498N P=0.756 |
|POLY 6 | P=0.328N P=0.266N P=0.512N P=0.256N |P=0.491 P=0.491N P=0.494N P=0.758N |
|LOGISTIC REGRESSION| P=0.327N P=0.216N P=0.487N P=0.212N |P=0.497 P=0.519N P=0.501N P=0.759 |
|COCH-ARM / FISHERS | P=0.330N P=0.256N P=0.496N P=0.246N |P=0.503 P=0.505N P=0.500N P=0.751N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/99 (4%) 6/96 (6%) 3/100 (3%) 6/100 (6%) |10/99 (10%) 9/97 (9%) 9/99 (9%) 5/99 (5%) |
|POLY-3 ADJUSTED (b)| 4.7% 7.7% 3.6% 7.4% |11.8% 10.3% 10.3% 5.9% |
|TERMINAL (d) | 4/57 (7%) 4/44 (9%) 2/47 (4%) 6/48 (13%) |9/59 (15%) 7/67 (10%) 8/60 (13%) 3/61 (5%) |
|FIRST INCIDENCE | 736 (T) 624 653 736 (T) |710 641 652 557 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.356 P=0.246 P=0.590N P=0.269 |P=0.126N P=0.389N P=0.481N P=0.126N |
|POLY 3 | P=0.376 P=0.322 P=0.507N P=0.344 |P=0.125N P=0.474N P=0.479N P=0.140N |
|POLY 1.5 | P=0.387 P=0.334 P=0.502N P=0.358 |P=0.127N P=0.494N P=0.490N P=0.147N |
|POLY 6 | P=0.366 P=0.312 P=0.509N P=0.331 |P=0.117N P=0.447N P=0.462N P=0.125N |
|LOGISTIC REGRESSION| P=0.374 P=0.301 P=0.513N P=0.269 |P=0.119N P=0.439N P=0.455N P=0.135N |
|COCH-ARM / FISHERS | P=0.403 P=0.355 P=0.494N P=0.380 |P=0.113N P=0.519N P=0.500N P=0.141N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 81
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/96 (0%) 3/100 (3%) 0/100 (0%) |0/99 (0%) 0/97 (0%) 0/99 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 3.5% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/44 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 0/67 (0%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | --- --- 405 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.564N (e) P=0.120 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.560N (e) P=0.123 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.555N (e) P=0.123 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.564N (e) P=0.123 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.583N (e) P=0.110 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.549N (e) P=0.125 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 1/96 (1%) 0/100 (0%) 1/100 (1%) |1/99 (1%) 2/97 (2%) 1/99 (1%) 1/99 (1%) |
|POLY-3 ADJUSTED (b)| 2.3% 1.3% 0.0% 1.2% |1.2% 2.3% 1.2% 1.2% |
|TERMINAL (d) | 0/57 (0%) 1/44 (2%) 0/47 (0%) 1/48 (2%) |1/59 (2%) 1/67 (2%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | 579 736 (T) --- 736 (T) |737 (T) 722 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.612N P=0.551N P=0.253N P=0.543N |P=0.551N P=0.541 P=0.757N P=0.754N |
|POLY 3 | P=0.592N P=0.534N P=0.244N P=0.520N |P=0.548N P=0.508 P=0.756N P=0.758 |
|POLY 1.5 | P=0.591N P=0.525N P=0.241N P=0.510N |P=0.550N P=0.502 P=0.758N P=0.756 |
|POLY 6 | P=0.593N P=0.545N P=0.247N P=0.529N |P=0.542N P=0.518 P=0.752N P=0.757N |
|LOGISTIC REGRESSION| P=0.587N P=0.487N P=0.223N P=0.474N |P=0.536N P=0.529 P=0.757N P=0.754N |
|COCH-ARM / FISHERS | P=0.589N P=0.512N P=0.246N P=0.496N |P=0.541N P=0.492 P=0.751N P=0.751N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 82
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Urinary Bladder: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/96 (0%) 1/100 (1%) 0/100 (0%) |2/99 (2%) 1/97 (1%) 0/99 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 1.2% 0.0% 1.2% 0.0% |2.4% 1.2% 0.0% 0.0% |
|TERMINAL (d) | 0/57 (0%) 0/44 (0%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 1/67 (2%) 0/60 (0%) 0/61 (0%) |
|FIRST INCIDENCE | 579 --- 724 --- |737 (T) 737 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.511N P=0.513N P=0.755 P=0.525N |P=0.246N P=0.456N P=0.235N P=0.232N |
|POLY 3 | P=0.495N P=0.519N P=0.756 P=0.511N |P=0.247N P=0.492N P=0.234N P=0.241N |
|POLY 1.5 | P=0.495N P=0.514N P=0.758 P=0.506N |P=0.245N P=0.499N P=0.236N P=0.243N |
|POLY 6 | P=0.496N P=0.524N P=0.754 P=0.515N |P=0.247N P=0.483N P=0.230N P=0.234N |
|LOGISTIC REGRESSION| P=0.488N P=0.458N P=0.751N P=0.468N |P=0.246N P=0.456N (e) (e) |
|COCH-ARM / FISHERS | P=0.494N P=0.508N P=0.749N P=0.497N |P=0.239N P=0.508N P=0.249N P=0.249N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |9/100 (9%) 10/100 (10%) 8/100 (8%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| |10.4% 11.1% 9.0% 8.0% |
|TERMINAL (d) | |7/59 (12%) 8/68 (12%) 5/60 (8%) 3/61 (5%) |
|FIRST INCIDENCE | |462 508 358 129 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.327N P=0.579N P=0.479N P=0.382N |
|POLY 3 | |P=0.310N P=0.540 P=0.479N P=0.388N |
|POLY 1.5 | |P=0.313N P=0.523 P=0.489N P=0.399N |
|POLY 6 | |P=0.297N P=0.564 P=0.465N P=0.366N |
|LOGISTIC REGRESSION| |P=0.203N P=0.501 P=0.506N P=0.293N |
|COCH-ARM / FISHERS | |P=0.301N P=0.500 P=0.500N P=0.398N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 83
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Uterus |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |2/100 (2%) 0/100 (0%) 1/100 (1%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| |2.3% 0.0% 1.1% 1.2% |
|TERMINAL (d) | |1/59 (2%) 0/68 (0%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | |565 --- 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.676 P=0.220N P=0.495N P=0.499N |
|POLY 3 | |P=0.672 P=0.230N P=0.494N P=0.504N |
|POLY 1.5 | |P=0.674 P=0.234N P=0.497N P=0.507N |
|POLY 6 | |P=0.674 P=0.225N P=0.490N P=0.496N |
|LOGISTIC REGRESSION| |P=0.687N P=0.267N P=0.503N P=0.497N |
|COCH-ARM / FISHERS | |P=0.686N P=0.249N P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Uterus: Cervix |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |2/100 (2%) 0/100 (0%) 1/100 (1%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| |2.3% 0.0% 1.1% 1.2% |
|TERMINAL (d) | |2/59 (3%) 0/68 (0%) 1/60 (2%) 1/61 (2%) |
|FIRST INCIDENCE | |737 (T) --- 737 (T) 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.679 P=0.208N P=0.494N P=0.488N |
|POLY 3 | |P=0.672 P=0.228N P=0.492N P=0.502N |
|POLY 1.5 | |P=0.674 P=0.233N P=0.496N P=0.506N |
|POLY 6 | |P=0.674 P=0.223N P=0.486N P=0.492N |
|LOGISTIC REGRESSION| |P=0.679 (e) P=0.494N P=0.488N |
|COCH-ARM / FISHERS | |P=0.686N P=0.249N P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 84
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |3/100 (3%) 3/100 (3%) 4/100 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| |3.5% 3.4% 4.5% 1.2% |
|TERMINAL (d) | |3/59 (5%) 2/68 (3%) 3/60 (5%) 1/61 (2%) |
|FIRST INCIDENCE | |737 (T) 722 488 737 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.220N P=0.597N P=0.507 P=0.295N |
|POLY 3 | |P=0.220N P=0.639N P=0.517 P=0.309N |
|POLY 1.5 | |P=0.221N P=0.648N P=0.509 P=0.313N |
|POLY 6 | |P=0.214N P=0.627N P=0.528 P=0.298N |
|LOGISTIC REGRESSION| |P=0.216N P=0.608N P=0.504 P=0.295N |
|COCH-ARM / FISHERS | |P=0.207N P=0.659N P=0.500 P=0.311N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |1/100 (1%) 3/100 (3%) 3/100 (3%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| |1.2% 3.4% 3.4% 2.3% |
|TERMINAL (d) | |1/59 (2%) 3/68 (4%) 1/60 (2%) 0/61 (0%) |
|FIRST INCIDENCE | |737 (T) 737 (T) 728 366 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.607N P=0.358 P=0.317 P=0.496 |
|POLY 3 | |P=0.598N P=0.323 P=0.315 P=0.505 |
|POLY 1.5 | |P=0.603N P=0.316 P=0.311 P=0.499 |
|POLY 6 | |P=0.586N P=0.333 P=0.321 P=0.516 |
|LOGISTIC REGRESSION| |P=0.522N P=0.358 P=0.322 P=0.729 |
|COCH-ARM / FISHERS | |P=0.597N P=0.311 P=0.311 P=0.500 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).