TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/08/98
EXPERIMENT: 89029 TEST: 05 TIME: 09:18:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = SHAM CONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 57 |
| |
| UNCENSORED DEATHS |
| 303 406 476 502 527 549 573 579 581 583 |
| 605 614 617 619 627 628 641 645 647 649 |
| 649 649 658 659 661 670 670 674 677 689 |
| 690 693 695 696 699 701 704 710 710 714 |
| 722 725 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.02 GAUSS |
| ---------------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 53 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 267 329 461 466 490 505 526 533 534 544 |
| 550 557 581 589 593 596 602 606 612 613 |
| 616 619 624 630 631 639 647 652 659 670 |
| 680 680 682 684 685 688 696 706 711 712 |
| 713 715 715 718 719 720 725 726 729 729 |
| 732 733 734 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 GAUSS |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 53 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 393 405 463 477 479 489 496 520 535 539 |
| 557 561 568 583 586 604 606 610 617 621 |
| 635 645 649 652 653 659 666 672 682 687 |
| 687 693 694 695 696 701 715 718 718 720 |
| 724 724 725 725 726 726 728 729 729 729 |
| 730 731 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 GAUSS |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 52 CENSORED DEATHS 0 TERMINAL 48 |
| |
| UNCENSORED DEATHS |
| 410 442 445 461 477 481 485 488 494 502 |
| 505 505 516 551 561 565 565 578 592 592 |
| 607 613 614 627 647 650 656 662 663 664 |
| 668 673 673 673 683 683 697 699 702 703 |
| 704 715 716 721 724 725 728 730 732 732 |
| 732 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|SHAM | 100.0 100.0 100.0 99.0 98.0 97.0 95.0 89.0 75.0 57.0 |
|CONTROL | |
| | |
|0.02 | 100.0 100.0 99.0 98.0 98.0 96.0 89.9 82.8 70.7 46.5 |
|GAUSS | |
| | |
|2 GAUSS | 100.0 100.0 100.0 100.0 98.0 95.0 90.0 84.0 74.0 47.0 |
| | |
| | |
|10 GAUSS | 100.0 100.0 100.0 100.0 99.0 93.0 87.0 80.0 70.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| SHAM 0.02 2 GAUSS 10 GAUSS |
| CONTROL GAUSS |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.0% 46.5% 47.0% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.583 P=0.197 P=0.282 P=0.244 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.9 627.8 637.8 618.5 |
|NATURAL DEATHS (C) | (13.3) (13.9) (12.9) (13.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 691.7 678.1 684.0 674.9 |
|(STANDARD ERROR) | ( 7.7) ( 9.2) ( 8.4) ( 9.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = SHAM CONTROL |
| ---------------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 462 494 495 533 543 543 547 553 561 565 |
| 591 597 598 602 608 610 613 616 617 620 |
| 622 625 646 655 660 667 673 673 674 680 |
| 690 690 691 697 704 722 723 723 729 736 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.02 GAUSS |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 68 |
| |
| UNCENSORED DEATHS |
| 498 508 522 532 563 582 583 588 589 590 |
| 598 611 619 631 632 641 662 669 669 672 |
| 674 679 682 683 685 692 711 715 721 722 |
| 727 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 GAUSS |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 60 |
| |
| UNCENSORED DEATHS |
| 358 429 488 497 501 508 556 557 603 610 |
| 617 617 619 637 639 643 647 648 652 656 |
| 665 673 678 681 685 686 687 694 696 700 |
| 701 703 710 711 723 725 728 728 731 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 GAUSS |
| --------------------- |
| |
| TOTAL 98 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 61 |
| |
| UNCENSORED DEATHS |
| 129 155 233 409 427 485 522 533 545 549 |
| 557 557 579 606 634 649 650 651 667 668 |
| 673 676 683 690 696 701 702 704 715 717 |
| 722 726 729 732 734 735 736 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|SHAM | 100.0 100.0 100.0 100.0 100.0 99.0 93.9 85.9 74.7 59.6 |
|CONTROL | |
| | |
|0.02 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 89.0 83.0 68.0 |
|GAUSS | |
| | |
|2 GAUSS | 100.0 100.0 100.0 99.0 99.0 98.0 94.0 91.0 79.0 60.0 |
| | |
| | |
|10 GAUSS | 100.0 98.0 96.9 96.9 95.9 93.9 90.8 86.7 81.6 62.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| SHAM 0.02 2 GAUSS 10 GAUSS |
| CONTROL GAUSS |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.6% 68.0% 60.0% 62.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.988 P=0.244N P=0.884N P=0.719N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.2 636.8 638.0 602.1 |
|NATURAL DEATHS (C) | (11.2) (11.9) (14.0) (25.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.2 705.0 697.4 686.1 |
|(STANDARD ERROR) | ( 7.1) ( 6.0) ( 7.4) (11.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS (EMF)
KAPLAN-MEIER SURVIVAL CURVES
SHAM CONTROL = 1
0.02 GAUSS = 2
2 GAUSS = 3
10 GAUSS = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 2 314 4
| 2 1 4 2213 1
| 42 32312 1 1 1
| 43 322 11
P 90 + 444 22223 11 11
E | 44 423323 2 11
R | 4 4 3 223 11 1
C | 4 4 42223 11
E 80 + 4 422 3 3
N | 422 11 1
T | 22243 11
| 222 2113
S 70 + 22121
U | 11
R | 42211 3
V | 2211
I 60 + 4131
V | 221 11
A | 44
L | 22 2
50 +
| 22
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 97 obs hidden.
MAGNETIC FIELDS (EMF)
KAPLAN-MEIER SURVIVAL CURVES
SHAM CONTROL = 1
0.02 GAUSS = 2
2 GAUSS = 3
10 GAUSS = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 4 3 3 1 122
| 4 4 4 3 31 2 221
| 4 4 33 211 2
95 + 4 4 33 2 2
| 4 3 4 113
| 4 4 131 2 2 3
| 444 33
P 90 + 441 12 33
E | 11 2
R | 4 4 22 2
C | 4 11 33
E 85 + 11 224
N | 23 2
T | 33 22
| 11 4 4
S 80 + 3 322
U | 11 3 3
R | 1 1 22
V | 11 1 44
I 75 + 11 2244
V | 1132 2
A | 33 22
L | 11 4 22
70 + 1133 44
| 2 2
| 33 4 22
| 1113 3
65 + 1 1
| 44
| 3 34
| 1 1
60 + 11
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 34 obs hidden.