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TDMS Study 89029-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 01/08/98      
EXPERIMENT: 89029 TEST: 05                                                                                     TIME: 09:18:50      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029      
PATHOLOGIST: KOVATCH, R.                                                                                       CAS: ELECTROMAG     
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 43     CENSORED DEATHS 0    TERMINAL 57        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   406   476   502   527   549   573   579   581   583                 |
 |      605   614   617   619   627   628   641   645   647   649                 |
 |      649   649   658   659   661   670   670   674   677   689                 |
 |      690   693   695   696   699   701   704   710   710   714                 |
 |      722   725   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.02    GAUSS                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 53     CENSORED DEATHS 0    TERMINAL 46        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      267   329   461   466   490   505   526   533   534   544                 |
 |      550   557   581   589   593   596   602   606   612   613                 |
 |      616   619   624   630   631   639   647   652   659   670                 |
 |      680   680   682   684   685   688   696   706   711   712                 |
 |      713   715   715   718   719   720   725   726   729   729                 |
 |      732   733   734                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 GAUSS                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 53     CENSORED DEATHS 0    TERMINAL 47        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      393   405   463   477   479   489   496   520   535   539                 |
 |      557   561   568   583   586   604   606   610   617   621                 |
 |      635   645   649   652   653   659   666   672   682   687                 |
 |      687   693   694   695   696   701   715   718   718   720                 |
 |      724   724   725   725   726   726   728   729   729   729                 |
 |      730   731   733                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 10 GAUSS                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 52     CENSORED DEATHS 0    TERMINAL 48        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      410   442   445   461   477   481   485   488   494   502                 |
 |      505   505   516   551   561   565   565   578   592   592                 |
 |      607   613   614   627   647   650   656   662   663   664                 |
 |      668   673   673   673   683   683   697   699   702   703                 |
 |      704   715   716   721   724   725   728   730   732   732                 |
 |      732   733                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0  99.0  98.0  97.0  95.0  89.0  75.0  57.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.02       |   100.0 100.0  99.0  98.0  98.0  96.0  89.9  82.8  70.7  46.5      |
 |GAUSS      |                                                                    |
 |           |                                                                    |
 |2 GAUSS    |   100.0 100.0 100.0 100.0  98.0  95.0  90.0  84.0  74.0  47.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 GAUSS   |   100.0 100.0 100.0 100.0  99.0  93.0  87.0  80.0  70.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                SHAM         0.02         2 GAUSS      10 GAUSS |
 |                                CONTROL      GAUSS                              |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       57.0%        46.5%        47.0%        48.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.583      P=0.197      P=0.282      P=0.244  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       632.9        627.8        637.8        618.5    |
 |NATURAL DEATHS (C)      |       (13.3)       (13.9)       (12.9)       (13.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       691.7        678.1        684.0        674.9    |
 |(STANDARD ERROR)        |       ( 7.7)       ( 9.2)       ( 8.4)       ( 9.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 59        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      462   494   495   533   543   543   547   553   561   565                 |
 |      591   597   598   602   608   610   613   616   617   620                 |
 |      622   625   646   655   660   667   673   673   674   680                 |
 |      690   690   691   697   704   722   723   723   729   736                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.02    GAUSS                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 68        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      498   508   522   532   563   582   583   588   589   590                 |
 |      598   611   619   631   632   641   662   669   669   672                 |
 |      674   679   682   683   685   692   711   715   721   722                 |
 |      727   729                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 GAUSS                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 60        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      358   429   488   497   501   508   556   557   603   610                 |
 |      617   617   619   637   639   643   647   648   652   656                 |
 |      665   673   678   681   685   686   687   694   696   700                 |
 |      701   703   710   711   723   725   728   728   731   732                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 10 GAUSS                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 98     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 61        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      129   155   233   409   427   485   522   533   545   549                 |
 |      557   557   579   606   634   649   650   651   667   668                 |
 |      673   676   683   690   696   701   702   704   715   717                 |
 |      722   726   729   732   734   735   736                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0 100.0 100.0  99.0  93.9  85.9  74.7  59.6      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.02       |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  89.0  83.0  68.0      |
 |GAUSS      |                                                                    |
 |           |                                                                    |
 |2 GAUSS    |   100.0 100.0 100.0  99.0  99.0  98.0  94.0  91.0  79.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 GAUSS   |   100.0  98.0  96.9  96.9  95.9  93.9  90.8  86.7  81.6  62.2      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                SHAM         0.02         2 GAUSS      10 GAUSS |
 |                                CONTROL      GAUSS                              |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       59.6%        68.0%        60.0%        62.2%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.988      P=0.244N     P=0.884N     P=0.719N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       626.2        636.8        638.0        602.1    |
 |NATURAL DEATHS (C)      |       (11.2)       (11.9)       (14.0)       (25.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       692.2        705.0        697.4        686.1    |
 |(STANDARD ERROR)        |       ( 7.1)       ( 6.0)       ( 7.4)       (11.7)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        0.02    GAUSS    = 2
                                                        2 GAUSS          = 3
                                                        10 GAUSS         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                          2    1   2          314    4
      |                                                     2           1     4  2213  1
      |                                                                          42 32312   1  1  1
      |                                                                              43    322    11
P  90 +                                                                               444    22223 11   11
E     |                                                                                 44     423323 2  11
R     |                                                                                        4 4  3 223 11 1
C     |                                                                                          4 4  42223  11
E  80 +                                                                                               4 422 3 3
N     |                                                                                                  422  11 1
T     |                                                                                                    22243 11
      |                                                                                                      222 2113
S  70 +                                                                                                          22121
U     |                                                                                                              11
R     |                                                                                                            42211 3
V     |                                                                                                              2211
I  60 +                                                                                                                4131
V     |                                                                                                                 221 11
A     |                                                                                                                  44
L     |                                                                                                                  22 2
   50 +
      |                                                                                                                     22
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 97 obs hidden.
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        0.02    GAUSS    = 2
                                                        2 GAUSS          = 3
                                                        10 GAUSS         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                    4                                   3               1     2
      |                      4   4                               3          3    1    122
      |                          4           4                           4  3        31 2  221
      |                                                                  4 4          33    211  2
   95 +                                                                    4         4 33        2  2
      |                                                                              4  3  4  113
      |                                                                                    4 4 131  2 2 3
      |                                                                                      444        33
P  90 +                                                                                        441    12 33
E     |                                                                                               11 2
R     |                                                                                         4  4     22 2
C     |                                                                                            4   11   33
E  85 +                                                                                                 11  224
N     |                                                                                                      23  2
T     |                                                                                                       33 22
      |                                                                                                  11   4   4
S  80 +                                                                                                        3 322
U     |                                                                                                   11     3 3
R     |                                                                                                    1  1    22
V     |                                                                                                       11 1  44
I  75 +                                                                                                          11 2244
V     |                                                                                                           1132  2
A     |                                                                                                              33 22
L     |                                                                                                            11  4 22
   70 +                                                                                                             1133 44
      |                                                                                                                   2 2
      |                                                                                                                33 4 22
      |                                                                                                              1113 3
   65 +                                                                                                                1  1
      |                                                                                                                     44
      |                                                                                                                   3 34
      |                                                                                                                   1 1
   60 +                                                                                                                     11
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 34 obs hidden.