TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/08/98
EXPERIMENT: 89029 TEST: 05 TIME: 09:18:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = SHAM CONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 57 |
| |
| UNCENSORED DEATHS |
| 303 406 476 502 527 549 573 579 581 583 |
| 605 614 617 619 627 628 641 645 647 649 |
| 649 649 658 659 661 670 670 674 677 689 |
| 690 693 695 696 699 701 704 710 710 714 |
| 722 725 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 GAUSS INTER. |
| ---------------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 365 470 489 527 535 552 554 555 557 558 |
| 559 561 570 576 577 579 582 586 591 600 |
| 600 621 636 645 645 666 675 677 687 688 |
| 698 707 714 715 716 720 720 725 726 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|SHAM | 100.0 100.0 100.0 99.0 98.0 97.0 95.0 89.0 75.0 57.0 |
|CONTROL | |
| | |
|10 | 100.0 100.0 100.0 99.0 99.0 98.0 94.9 78.8 74.7 59.6 |
|GAUSS INTER| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| SHAM 10 |
| CONTROL GAUSS INTER. |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.0% 59.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.923N P=0.923N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.9 616.3 |
|NATURAL DEATHS (C) | (13.3) (13.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 691.7 687.6 |
|(STANDARD ERROR) | ( 7.7) ( 8.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = SHAM CONTROL |
| ---------------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 462 494 495 533 543 543 547 553 561 565 |
| 591 597 598 602 608 610 613 616 617 620 |
| 622 625 646 655 660 667 673 673 674 680 |
| 690 690 691 697 704 722 723 723 729 736 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 GAUSS INTER. |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 58 |
| |
| UNCENSORED DEATHS |
| 430 434 434 440 448 462 480 505 511 526 |
| 535 550 575 585 591 594 602 608 624 624 |
| 627 628 632 641 641 645 652 653 668 689 |
| 701 702 710 711 713 715 715 718 727 729 |
| 730 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS (EMF)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|SHAM | 100.0 100.0 100.0 100.0 100.0 99.0 93.9 85.9 74.7 59.6 |
|CONTROL | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 93.0 89.0 83.0 72.0 58.0 |
|GAUSS INTER| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| SHAM 10 |
| CONTROL GAUSS INTER. |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.6% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.877 P=0.877 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.2 610.4 |
|NATURAL DEATHS (C) | (11.2) (14.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.2 683.8 |
|(STANDARD ERROR) | ( 7.1) ( 8.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS (EMF)
KAPLAN-MEIER SURVIVAL CURVES
SHAM CONTROL = 1
10 GAUSS INTER. = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 2 1 2
| 1 1 2 1 2
| 1 12
95 + 12 1
| 12 1
| 11
| 11
90 + 1 1
| 22 11
P | 22 11
E | 22 11
R 85 +
C | 22 1 1
E | 11
N | 2 22
T 80 +
| 2 2
S | 2 2 11 1
U | 2 2
R 75 + 2 11
V | 22
I | 11
V | 1 1
A 70 + 22
L | 22
| 1122
| 22
65 + 11
|
| 1122
|
60 + 1 1 2
|
| 1 11
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
MAGNETIC FIELDS (EMF)
KAPLAN-MEIER SURVIVAL CURVES
SHAM CONTROL = 1
10 GAUSS INTER. = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 1 1
| 22 1 1
| 22 11
95 + 2 2
| 2 2 11
| 2 2 1 1
| 2 2
90 + 22 1 1
| 2 2 11
P | 2 22
E | 2 211
R 85 + 11
C | 22
E | 22 2
N | 11
T 80 +
| 11
S | 1221
U | 11 1
R 75 + 22 11
V | 22 11
I | 2 2
V | 2112
A 70 + 11 2
L |
| 22
| 111
65 + 1221
|
| 22
| 1 1
60 + 11
|
| 22
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
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