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TDMS Study 89029-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 01/08/98      
EXPERIMENT: 89029 TEST: 05                                                                                     TIME: 09:18:50      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029      
PATHOLOGIST: KOVATCH, R.                                                                                       CAS: ELECTROMAG     
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 43     CENSORED DEATHS 0    TERMINAL 57        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   406   476   502   527   549   573   579   581   583                 |
 |      605   614   617   619   627   628   641   645   647   649                 |
 |      649   649   658   659   661   670   670   674   677   689                 |
 |      690   693   695   696   699   701   704   710   710   714                 |
 |      722   725   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 GAUSS INTER.                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 59        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      365   470   489   527   535   552   554   555   557   558                 |
 |      559   561   570   576   577   579   582   586   591   600                 |
 |      600   621   636   645   645   666   675   677   687   688                 |
 |      698   707   714   715   716   720   720   725   726   726                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0  99.0  98.0  97.0  95.0  89.0  75.0  57.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0  99.0  99.0  98.0  94.9  78.8  74.7  59.6      |
 |GAUSS INTER|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                SHAM                      10                    |
 |                                CONTROL                   GAUSS INTER.          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       57.0%                     59.6%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.923N                  P=0.923N              |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       632.9                     616.3                 |
 |NATURAL DEATHS (C)      |       (13.3)                    (13.2)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       691.7                     687.6                 |
 |(STANDARD ERROR)        |       ( 7.7)                    ( 8.0)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 59        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      462   494   495   533   543   543   547   553   561   565                 |
 |      591   597   598   602   608   610   613   616   617   620                 |
 |      622   625   646   655   660   667   673   673   674   680                 |
 |      690   690   691   697   704   722   723   723   729   736                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 GAUSS INTER.                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 58        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      430   434   434   440   448   462   480   505   511   526                 |
 |      535   550   575   585   591   594   602   608   624   624                 |
 |      627   628   632   641   641   645   652   653   668   689                 |
 |      701   702   710   711   713   715   715   718   727   729                 |
 |      730   732                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0 100.0 100.0  99.0  93.9  85.9  74.7  59.6      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0  93.0  89.0  83.0  72.0  58.0      |
 |GAUSS INTER|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                SHAM                      10                    |
 |                                CONTROL                   GAUSS INTER.          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       59.6%                     58.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.877                   P=0.877               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       626.2                     610.4                 |
 |NATURAL DEATHS (C)      |       (11.2)                    (14.9)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       692.2                     683.8                 |
 |(STANDARD ERROR)        |       ( 7.1)                    ( 8.8)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        10 GAUSS INTER.  = 2

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                               1         2
      |                                                 1         2     1          2
      |                                                                 1          1 2 1    2
      |                                                                                1    12
   95 +                                                                                     12 1
      |                                                                                        12 1
      |                                                                                           11
      |                                                                                            11
   90 +                                                                                             1   1
      |                                                                                         22      11
P     |                                                                                          22      11
E     |                                                                                           22      11
R  85 +
C     |                                                                                            22      1 1
E     |                                                                                                      11
N     |                                                                                             2 22
T  80 +
      |                                                                                                2  2
S     |                                                                                                   2 2 11 1
U     |                                                                                                     2 2
R  75 +                                                                                                       2  11
V     |                                                                                                           22
I     |                                                                                                           11
V     |                                                                                                            1 1
A  70 +                                                                                                              22
L     |                                                                                                               22
      |                                                                                                              1122
      |                                                                                                                 22
   65 +                                                                                                               11
      |
      |                                                                                                                1122
      |
   60 +                                                                                                                 1 1  2
      |
      |                                                                                                                   1 11
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        10 GAUSS INTER.  = 2

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                   2    1
      |                                                                          1    1
      |                                                                     22        1      1
      |                                                                      22              11
   95 +                                                                       2  2
      |                                                                          2  2         11
      |                                                                             2   2      1 1
      |                                                                                 2   2
   90 +                                                                                     22   1    1
      |                                                                                      2 2      11
P     |                                                                                        2   22
E     |                                                                                             2 211
R  85 +                                                                                                 11
C     |                                                                                               22
E     |                                                                                                22  2
N     |                                                                                                  11
T  80 +
      |                                                                                                   11
S     |                                                                                                    1221
U     |                                                                                                       11 1
R  75 +                                                                                                      22  11
V     |                                                                                                       22  11
I     |                                                                                                        2  2
V     |                                                                                                           2112
A  70 +                                                                                                             11 2
L     |
      |                                                                                                                22
      |                                                                                                              111
   65 +                                                                                                                1221
      |
      |                                                                                                                  22
      |                                                                                                                   1 1
   60 +                                                                                                                     11
      |
      |                                                                                                                     22
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.
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