TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF MAGNETIC FIELDS (EMF) =============================================================== Male Mice ------------ Organ Morphology ----- ---------- Adrenal Medulla Hyperplasia Intestine Small, Ileum: Muscularis Hypertrophy Islets, Pancreatic Hyperplasia Kidney: Cortex Infiltration Cellular Lymphocyte Liver: Hepatocyte Vacuolization Cytoplasmic Nose Inflammation Pancreas Vacuolization Cytoplasmic Preputial Gland Atrophy Inflammation Seminal Vesicle Cyst Thymus Atrophy =============================================================== Female Mice ------------ Organ Morphology ----- ---------- Bone Marrow Myelofibrosis Brain: Thalamus Mineralization Clitoral Gland Cyst Lymph Node, Mesenteric Hyperplasia Reticulum Cell Infiltration Cellular Histiocyte Spleen Hematopoietic Cell Proliferation Stomach, Glandular: Epithelium Atrophy Thyroid Gland: Follicle Cyst =============================================================== Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 1 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.2% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | --- --- | --- 607 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.237 | |POLY 3 | (e) | P=0.243 | |POLY 1.5 | (e) | P=0.244 | |POLY 6 | (e) | P=0.241 | |LOGISTIC REGRESSION| (e) | P=0.279 | |COCH-ARM / FISHERS | (e) | P=0.267 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Capsule | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 86/99 (87%) 85/97 (88%) | 91/92 (99%) 99/99 (100%) | |POLY-3 ADJUSTED (b)| 88.5% 90.4% | 99.0% 100.0% | |TERMINAL (d) | 69/76 (91%) 67/73 (92%) | 70/70 (100%) 77/77 (100%) | |FIRST INCIDENCE | 386 420 | 334 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.418 | P=0.498 | |POLY 3 | P=0.422 | P=0.497 | |POLY 1.5 | P=0.455 | P=0.484 | |POLY 6 | P=0.402 | P=0.524 | |LOGISTIC REGRESSION| P=0.441 | P=0.491 | |COCH-ARM / FISHERS | P=0.522 | P=0.482 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 2 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 5/97 (5%) | 0/92 (0%) 3/99 (3%) | |POLY-3 ADJUSTED (b)| 4.3% 5.7% | 0.0% 3.4% | |TERMINAL (d) | 3/76 (4%) 5/73 (7%) | 0/70 (0%) 3/77 (4%) | |FIRST INCIDENCE | 717 734 (T) | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.475 | P=0.140 | |POLY 3 | P=0.474 | P=0.125 | |POLY 1.5 | P=0.479 | P=0.127 | |POLY 6 | P=0.468 | P=0.123 | |LOGISTIC REGRESSION| P=0.463 | P=0.140 | |COCH-ARM / FISHERS | P=0.487 | P=0.137 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/99 (9%) 5/97 (5%) | 0/92 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 9.8% 5.7% | 0.0% 0.0% | |TERMINAL (d) | 9/76 (12%) 5/73 (7%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.223N | (e) | |POLY 3 | P=0.231N | (e) | |POLY 1.5 | P=0.225N | (e) | |POLY 6 | P=0.237N | (e) | |LOGISTIC REGRESSION| P=0.223N | (e) | |COCH-ARM / FISHERS | P=0.215N | (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 3 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/99 (15%) 19/97 (20%) | 2/92 (2%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 16.3% 21.7% | 2.3% 0.0% | |TERMINAL (d) | 14/76 (18%) 18/73 (25%) | 2/70 (3%) 0/77 (0%) | |FIRST INCIDENCE | 683 716 | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.239 | P=0.218N | |POLY 3 | P=0.234 | P=0.227N | |POLY 1.5 | P=0.245 | P=0.222N | |POLY 6 | P=0.222 | P=0.233N | |LOGISTIC REGRESSION| P=0.219 | (e) | |COCH-ARM / FISHERS | P=0.264 | P=0.231N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) --- | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.248N | (e) | |POLY 3 | P=0.255N | (e) | |POLY 1.5 | P=0.251N | (e) | |POLY 6 | P=0.258N | (e) | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | P=0.254N | (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 4 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Glomerulosa | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 7/97 (7%) | 0/92 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 3.2% 7.9% | 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 5/73 (7%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 579 553 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.156 | (e) | |POLY 3 | P=0.148 | (e) | |POLY 1.5 | P=0.152 | (e) | |POLY 6 | P=0.144 | (e) | |LOGISTIC REGRESSION| P=0.164 | (e) | |COCH-ARM / FISHERS | P=0.157 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex: Zona Reticularis | | Degeneration Fatty | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 0/97 (0%) | 4/92 (4%) 3/99 (3%) | |POLY-3 ADJUSTED (b)| 1.1% 0.0% | 4.6% 3.4% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 4/70 (6%) 3/77 (4%) | |FIRST INCIDENCE | 683 --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.519N | P=0.449N | |POLY 3 | P=0.520N | P=0.480N | |POLY 1.5 | P=0.516N | P=0.470N | |POLY 6 | P=0.525N | P=0.490N | |LOGISTIC REGRESSION| P=0.494N | P=0.449N | |COCH-ARM / FISHERS | P=0.505N | P=0.459N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 5 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 5/96 (5%) | 3/90 (3%) 3/98 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 5.7% | 3.5% 3.4% | |TERMINAL (d) | 0/76 (0%) 5/73 (7%) | 3/70 (4%) 3/76 (4%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.031 * | P=0.623N | |POLY 3 | P=0.031 * | P=0.638N | |POLY 1.5 | P=0.031 * | P=0.628N | |POLY 6 | P=0.030 * | P=0.648N | |LOGISTIC REGRESSION| P=0.031 * | P=0.623N | |COCH-ARM / FISHERS | P=0.028 * | P=0.618N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Blood Vessel: Aorta | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/97 (0%) 0/98 (0%) | 2/98 (2%) 0/96 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.2% 0.0% | |TERMINAL (d) | 0/75 (0%) 0/72 (0%) | 0/70 (0%) 0/75 (0%) | |FIRST INCIDENCE | --- --- | 625 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.242N | |POLY 3 | (e) | P=0.245N | |POLY 1.5 | (e) | P=0.244N | |POLY 6 | (e) | P=0.248N | |LOGISTIC REGRESSION| (e) | P=0.252N | |COCH-ARM / FISHERS | (e) | P=0.254N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 6 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 3/100 (3%) | 0/96 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.3% | 0.0% 1.1% | |TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 0/70 (0%) 1/77 (1%) | |FIRST INCIDENCE | --- 729 | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.119 | P=0.519 | |POLY 3 | P=0.119 | P=0.500 | |POLY 1.5 | P=0.121 | P=0.500 | |POLY 6 | P=0.118 | P=0.500 | |LOGISTIC REGRESSION| P=0.114 | P=0.519 | |COCH-ARM / FISHERS | P=0.125 | P=0.510 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 33/99 (33%) 25/100 (25%) | 23/96 (24%) 19/100 (19%) | |POLY-3 ADJUSTED (b)| 34.9% 26.7% | 25.3% 20.5% | |TERMINAL (d) | 23/76 (30%) 15/74 (20%) | 12/70 (17%) 12/77 (16%) | |FIRST INCIDENCE | 497 533 | 552 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.189N | P=0.256N | |POLY 3 | P=0.145N | P=0.271N | |POLY 1.5 | P=0.138N | P=0.259N | |POLY 6 | P=0.153N | P=0.289N | |LOGISTIC REGRESSION| P=0.116N | P=0.248N | |COCH-ARM / FISHERS | P=0.128N | P=0.251N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 7 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Infiltration Cellular Focal Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 2/100 (2%) | 0/96 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.3% 2.2% | 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 2/74 (3%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 715 734 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.515N | (e) | |POLY 3 | P=0.511N | (e) | |POLY 1.5 | P=0.505N | (e) | |POLY 6 | P=0.519N | (e) | |LOGISTIC REGRESSION| P=0.519N | (e) | |COCH-ARM / FISHERS | P=0.495N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Myelofibrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 2/100 (2%) | 10/96 (10%) 21/100 (21%) | |POLY-3 ADJUSTED (b)| 0.0% 2.2% | 11.3% 23.0% | |TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 10/70 (14%) 18/77 (23%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 576 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.233 | P=0.043 * | |POLY 3 | P=0.236 | P=0.029 * | |POLY 1.5 | P=0.238 | P=0.031 * | |POLY 6 | P=0.235 | P=0.028 * | |LOGISTIC REGRESSION| P=0.233 | P=0.027 * | |COCH-ARM / FISHERS | P=0.251 | P=0.033 * | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 8 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow: Myeloid Cell | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/100 (0%) | 3/96 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | 3.4% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/74 (0%) | 1/70 (1%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) --- | 666 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.245N | P=0.116N | |POLY 3 | P=0.245N | P=0.116N | |POLY 1.5 | P=0.241N | P=0.114N | |POLY 6 | P=0.250N | P=0.120N | |LOGISTIC REGRESSION| (e) | P=0.116N | |COCH-ARM / FISHERS | P=0.246N | P=0.116N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Brain: Thalamus | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 70/100 (70%) 63/100 (63%) | 47/99 (47%) 72/100 (72%) | |POLY-3 ADJUSTED (b)| 71.8% 65.6% | 50.4% 73.9% | |TERMINAL (d) | 55/76 (72%) 47/74 (64%) | 35/70 (50%) 55/77 (71%) | |FIRST INCIDENCE | 386 415 | 461 449 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.306N | P=0.007 ** | |POLY 3 | P=0.215N | P<0.001 ** | |POLY 1.5 | P=0.203N | P<0.001 ** | |POLY 6 | P=0.226N | P<0.001 ** | |LOGISTIC REGRESSION| P=0.187N | P<0.001 ** | |COCH-ARM / FISHERS | P=0.184N | P<0.001 ** | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 9 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral Gland | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 80/89 (90%) 74/82 (90%) | |POLY-3 ADJUSTED (b)| | 92.1% 90.7% | |TERMINAL (d) | | 64/69 (93%) 63/69 (91%) | |FIRST INCIDENCE | | 397 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.207N | |POLY 3 | | P=0.486N | |POLY 1.5 | | P=0.527N | |POLY 6 | | P=0.465N | |LOGISTIC REGRESSION| | P=0.602 | |COCH-ARM / FISHERS | | P=0.571 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 84/89 (94%) 71/82 (87%) | |POLY-3 ADJUSTED (b)| | 96.0% 89.1% | |TERMINAL (d) | | 67/69 (97%) 64/69 (93%) | |FIRST INCIDENCE | | 397 534 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.015N* | |POLY 3 | | P=0.069N | |POLY 1.5 | | P=0.064N | |POLY 6 | | P=0.081N | |LOGISTIC REGRESSION| | P=0.041N* | |COCH-ARM / FISHERS | | P=0.068N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 10 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Granuloma Sperm | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 0/98 (0%) | | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | | |TERMINAL (d) | 1/76 (1%) 0/73 (0%) | | |FIRST INCIDENCE | 684 --- | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.254N | | |POLY 3 | P=0.250N | | |POLY 1.5 | P=0.245N | | |POLY 6 | P=0.255N | | |LOGISTIC REGRESSION| P=0.239N | | |COCH-ARM / FISHERS | P=0.249N | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 24/98 (24%) 24/98 (24%) | | |POLY-3 ADJUSTED (b)| 26.1% 26.9% | | |TERMINAL (d) | 21/76 (28%) 20/73 (27%) | | |FIRST INCIDENCE | 624 605 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.498 | | |POLY 3 | P=0.522 | | |POLY 1.5 | P=0.539 | | |POLY 6 | P=0.504 | | |LOGISTIC REGRESSION| P=0.504 | | |COCH-ARM / FISHERS | P=0.566N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 11 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 2/98 (2%) | | |POLY-3 ADJUSTED (b)| 0.0% 2.3% | | |TERMINAL (d) | 0/76 (0%) 2/73 (3%) | | |FIRST INCIDENCE | --- 734 (T) | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.230 | | |POLY 3 | P=0.235 | | |POLY 1.5 | P=0.236 | | |POLY 6 | P=0.234 | | |LOGISTIC REGRESSION| P=0.230 | | |COCH-ARM / FISHERS | P=0.249 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Spermatocele | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 6/98 (6%) | | |POLY-3 ADJUSTED (b)| 2.2% 6.7% | | |TERMINAL (d) | 2/76 (3%) 5/73 (7%) | | |FIRST INCIDENCE | 734 (T) 547 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.129 | | |POLY 3 | P=0.132 | | |POLY 1.5 | P=0.135 | | |POLY 6 | P=0.129 | | |LOGISTIC REGRESSION| P=0.137 | | |COCH-ARM / FISHERS | P=0.139 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 12 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Eye: Cornea | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/0 (0%) 0/1 (0%) | 2/2 (100%) 0/2 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 100.0% 0.0% | |TERMINAL (d) | 0/0 (0%) 0/1 (0%) | 2/2 (100%) 0/0 (0%) | |FIRST INCIDENCE | --- --- | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=1.000N | |POLY 3 | (e) | P=1.000N | |POLY 1.5 | (e) | P=0.887N | |POLY 6 | (e) | P=1.000N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.167N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Gallbladder: Epithelium | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/84 (0%) 2/82 (2%) | 5/70 (7%) 11/91 (12%) | |POLY-3 ADJUSTED (b)| 0.0% 2.5% | 7.5% 12.8% | |TERMINAL (d) | 0/69 (0%) 1/72 (1%) | 4/62 (7%) 9/76 (12%) | |FIRST INCIDENCE | --- 686 | 725 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.239 | P=0.170 | |POLY 3 | P=0.239 | P=0.200 | |POLY 1.5 | P=0.238 | P=0.205 | |POLY 6 | P=0.240 | P=0.192 | |LOGISTIC REGRESSION| P=0.225 | P=0.234 | |COCH-ARM / FISHERS | P=0.242 | P=0.221 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 13 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Harderian Gland | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/99 (11%) 14/99 (14%) | 27/98 (28%) 36/97 (37%) | |POLY-3 ADJUSTED (b)| 12.0% 15.5% | 30.2% 40.3% | |TERMINAL (d) | 11/76 (15%) 12/74 (16%) | 25/70 (36%) 33/77 (43%) | |FIRST INCIDENCE | 734 (T) 581 | 551 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.308 | P=0.205 | |POLY 3 | P=0.314 | P=0.102 | |POLY 1.5 | P=0.322 | P=0.103 | |POLY 6 | P=0.308 | P=0.101 | |LOGISTIC REGRESSION| P=0.296 | P=0.097 | |COCH-ARM / FISHERS | P=0.335 | P=0.101 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Heart | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 2/100 (2%) | 0/98 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.1% 2.2% | 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 386 420 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.686 | (e) | |POLY 3 | P=0.687 | (e) | |POLY 1.5 | P=0.689 | (e) | |POLY 6 | P=0.685 | (e) | |LOGISTIC REGRESSION| P=0.588N | (e) | |COCH-ARM / FISHERS | P=0.689N | (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 14 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Heart: Valve | | Thrombosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/98 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.2% | 0.0% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | --- 420 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.236 | (e) | |POLY 3 | P=0.237 | (e) | |POLY 1.5 | P=0.238 | (e) | |POLY 6 | P=0.237 | (e) | |LOGISTIC REGRESSION| P=0.293 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Large, Cecum: Lymphoid Tissue | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 41/90 (46%) 46/85 (54%) | 25/78 (32%) 32/92 (35%) | |POLY-3 ADJUSTED (b)| 47.4% 56.0% | 32.7% 36.2% | |TERMINAL (d) | 37/76 (49%) 42/73 (58%) | 22/69 (32%) 26/77 (34%) | |FIRST INCIDENCE | 624 547 | 397 449 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.196 | P=0.305 | |POLY 3 | P=0.169 | P=0.373 | |POLY 1.5 | P=0.169 | P=0.389 | |POLY 6 | P=0.165 | P=0.354 | |LOGISTIC REGRESSION| P=0.154 | P=0.450 | |COCH-ARM / FISHERS | P=0.163 | P=0.416 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 15 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Small, Ileum | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/91 (0%) 0/84 (0%) | 1/78 (1%) 2/93 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.3% 2.3% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 1/69 (1%) 2/77 (3%) | |FIRST INCIDENCE | --- --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.538 | |POLY 3 | (e) | P=0.533 | |POLY 1.5 | (e) | P=0.536 | |POLY 6 | (e) | P=0.528 | |LOGISTIC REGRESSION| (e) | P=0.538 | |COCH-ARM / FISHERS | (e) | P=0.566 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Small, Ileum: Muscularis | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/91 (0%) 7/84 (8%) | 17/78 (22%) 15/93 (16%) | |POLY-3 ADJUSTED (b)| 0.0% 8.6% | 22.8% 17.2% | |TERMINAL (d) | 0/76 (0%) 4/72 (6%) | 16/69 (23%) 12/77 (16%) | |FIRST INCIDENCE | --- 533 | 608 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.010 * | P=0.312N | |POLY 3 | P=0.008 ** | P=0.242N | |POLY 1.5 | P=0.007 ** | P=0.232N | |POLY 6 | P=0.008 ** | P=0.257N | |LOGISTIC REGRESSION| P=0.004 ** | P=0.235N | |COCH-ARM / FISHERS | P=0.005 ** | P=0.227N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 16 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Small, Ileum: Peyer's Patch | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/91 (0%) 0/84 (0%) | 4/78 (5%) 5/93 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 5.3% 5.8% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 3/69 (4%) 5/77 (7%) | |FIRST INCIDENCE | --- --- | 334 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.559 | |POLY 3 | (e) | P=0.571 | |POLY 1.5 | (e) | P=0.581 | |POLY 6 | (e) | P=0.560 | |LOGISTIC REGRESSION| (e) | P=0.623 | |COCH-ARM / FISHERS | (e) | P=0.609 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Small, Jejunum: Muscularis | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/89 (0%) 2/85 (2%) | 6/79 (8%) 7/92 (8%) | |POLY-3 ADJUSTED (b)| 0.0% 2.5% | 7.9% 8.1% | |TERMINAL (d) | 0/76 (0%) 1/73 (1%) | 6/69 (9%) 6/77 (8%) | |FIRST INCIDENCE | --- 579 | 735 (T) 704 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.233 | P=0.575 | |POLY 3 | P=0.233 | P=0.587 | |POLY 1.5 | P=0.233 | P=0.595 | |POLY 6 | P=0.232 | P=0.577 | |LOGISTIC REGRESSION| P=0.207 | P=0.572 | |COCH-ARM / FISHERS | P=0.237 | P=0.612N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 17 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Intestine Small, Jejunum: Peyer's Patch | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/89 (1%) 1/85 (1%) | 3/79 (4%) 7/92 (8%) | |POLY-3 ADJUSTED (b)| 1.2% 1.2% | 4.0% 8.1% | |TERMINAL (d) | 1/76 (1%) 1/73 (1%) | 3/69 (4%) 7/77 (9%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.752 | P=0.211 | |POLY 3 | P=0.754 | P=0.213 | |POLY 1.5 | P=0.755 | P=0.219 | |POLY 6 | P=0.753 | P=0.206 | |LOGISTIC REGRESSION| P=0.752 | P=0.211 | |COCH-ARM / FISHERS | P=0.740 | P=0.234 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Islets, Pancreatic | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 97/99 (98%) 89/98 (91%) | 40/87 (46%) 47/94 (50%) | |POLY-3 ADJUSTED (b)| 98.2% 93.3% | 47.7% 50.9% | |TERMINAL (d) | 75/76 (99%) 70/74 (95%) | 35/70 (50%) 36/76 (47%) | |FIRST INCIDENCE | 386 415 | 334 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.264N | P=0.333 | |POLY 3 | P=0.076N | P=0.390 | |POLY 1.5 | P=0.051N | P=0.376 | |POLY 6 | P=0.114N | P=0.398 | |LOGISTIC REGRESSION| P=0.040N* | P=0.366 | |COCH-ARM / FISHERS | P=0.028N* | P=0.347 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 18 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex | | Congestion | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) --- | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.248N | (e) | |POLY 3 | P=0.256N | (e) | |POLY 1.5 | P=0.252N | (e) | |POLY 6 | P=0.261N | (e) | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | P=0.254N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 23/99 (23%) 22/97 (23%) | 0/92 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 24.7% 25.0% | 0.0% 0.0% | |TERMINAL (d) | 19/76 (25%) 20/73 (27%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 579 579 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.563N | (e) | |POLY 3 | P=0.553 | (e) | |POLY 1.5 | P=0.565N | (e) | |POLY 6 | P=0.528 | (e) | |LOGISTIC REGRESSION| P=0.547 | (e) | |COCH-ARM / FISHERS | P=0.531N | (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 19 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 19/99 (19%) 37/97 (38%) | 24/92 (26%) 16/99 (16%) | |POLY-3 ADJUSTED (b)| 20.4% 41.6% | 27.5% 17.7% | |TERMINAL (d) | 16/76 (21%) 32/73 (44%) | 20/70 (29%) 14/77 (18%) | |FIRST INCIDENCE | 579 553 | 542 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.002 ** | P=0.066N | |POLY 3 | P<0.001 ** | P=0.080N | |POLY 1.5 | P=0.002 ** | P=0.073N | |POLY 6 | P<0.001 ** | P=0.090N | |LOGISTIC REGRESSION| P=0.002 ** | P=0.079N | |COCH-ARM / FISHERS | P=0.003 ** | P=0.066N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex | | Metaplasia Focal Osseous | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 4/97 (4%) | 4/92 (4%) 3/99 (3%) | |POLY-3 ADJUSTED (b)| 4.3% 4.6% | 4.6% 3.3% | |TERMINAL (d) | 3/76 (4%) 4/73 (6%) | 1/70 (1%) 3/77 (4%) | |FIRST INCIDENCE | 666 734 (T) | 397 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.619 | P=0.467N | |POLY 3 | P=0.614 | P=0.481N | |POLY 1.5 | P=0.621 | P=0.470N | |POLY 6 | P=0.607 | P=0.493N | |LOGISTIC REGRESSION| P=0.606 | P=0.439N | |COCH-ARM / FISHERS | P=0.628 | P=0.459N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 20 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 79/99 (80%) 77/97 (79%) | 1/92 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 83.6% 83.8% | 1.2% 0.0% | |TERMINAL (d) | 66/76 (87%) 63/73 (86%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 579 505 | 625 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.489 | P=0.502N | |POLY 3 | P=0.568 | P=0.483N | |POLY 1.5 | P=0.579 | P=0.478N | |POLY 6 | P=0.561 | P=0.490N | |LOGISTIC REGRESSION| P=0.409 | P=0.474N | |COCH-ARM / FISHERS | P=0.542N | P=0.482N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Accumulation, Hyaline Droplet | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 3/99 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 3.3% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 1/77 (1%) | |FIRST INCIDENCE | --- --- | --- 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.132 | |POLY 3 | (e) | P=0.128 | |POLY 1.5 | (e) | P=0.129 | |POLY 6 | (e) | P=0.127 | |LOGISTIC REGRESSION| (e) | P=0.143 | |COCH-ARM / FISHERS | (e) | P=0.137 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 21 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Degeneration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 72/99 (73%) 71/97 (73%) | 4/99 (4%) 1/97 (1%) | |POLY-3 ADJUSTED (b)| 77.0% 77.5% | 4.4% 1.1% | |TERMINAL (d) | 62/76 (82%) 59/73 (81%) | 4/76 (5%) 1/73 (1%) | |FIRST INCIDENCE | 603 533 | 734 (T) 734 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.446 | P=0.195N | |POLY 3 | P=0.539 | P=0.202N | |POLY 1.5 | P=0.533 | P=0.197N | |POLY 6 | P=0.557 | P=0.207N | |LOGISTIC REGRESSION| P=0.363 | P=0.195N | |COCH-ARM / FISHERS | P=0.535 | P=0.191N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Dilatation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 2/97 (2%) | 1/92 (1%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 2.2% 2.3% | 1.2% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 520 505 | 608 623 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.680 | P=0.759 | |POLY 3 | P=0.679 | P=0.745N | |POLY 1.5 | P=0.682 | P=0.741N | |POLY 6 | P=0.675 | P=0.750N | |LOGISTIC REGRESSION| P=0.619N | P=0.734N | |COCH-ARM / FISHERS | P=0.682 | P=0.733N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 22 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.2% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | --- --- | --- 580 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.240 | |POLY 3 | (e) | P=0.244 | |POLY 1.5 | (e) | P=0.245 | |POLY 6 | (e) | P=0.243 | |LOGISTIC REGRESSION| (e) | P=0.265 | |COCH-ARM / FISHERS | (e) | P=0.267 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Medulla | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 54/99 (55%) 47/97 (48%) | 47/92 (51%) 57/99 (58%) | |POLY-3 ADJUSTED (b)| 57.2% 53.4% | 52.8% 61.9% | |TERMINAL (d) | 44/76 (58%) 45/73 (62%) | 41/70 (59%) 53/77 (69%) | |FIRST INCIDENCE | 520 553 | 334 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.287N | P=0.246 | |POLY 3 | P=0.353N | P=0.132 | |POLY 1.5 | P=0.302N | P=0.164 | |POLY 6 | P=0.425N | P=0.100 | |LOGISTIC REGRESSION| P=0.337N | P=0.191 | |COCH-ARM / FISHERS | P=0.239N | P=0.225 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 23 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Medulla | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/97 (2%) | 3/92 (3%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 1.1% 2.3% | 3.5% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 666 582 | 625 534 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.490 | P=0.301N | |POLY 3 | P=0.489 | P=0.286N | |POLY 1.5 | P=0.492 | P=0.281N | |POLY 6 | P=0.487 | P=0.293N | |LOGISTIC REGRESSION| P=0.547 | P=0.262N | |COCH-ARM / FISHERS | P=0.492 | P=0.283N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Pelvis | | Calculus Micro Observation Only | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/97 (0%) | 3/92 (3%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 2.2% | |TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 3/70 (4%) 2/77 (3%) | |FIRST INCIDENCE | --- --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.457N | |POLY 3 | (e) | P=0.475N | |POLY 1.5 | (e) | P=0.469N | |POLY 6 | (e) | P=0.483N | |LOGISTIC REGRESSION| (e) | P=0.457N | |COCH-ARM / FISHERS | (e) | P=0.465N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 24 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/99 (0%) | 1/98 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.1% 3.3% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 3/77 (4%) | |FIRST INCIDENCE | --- --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.341 | |POLY 3 | (e) | P=0.310 | |POLY 1.5 | (e) | P=0.312 | |POLY 6 | (e) | P=0.307 | |LOGISTIC REGRESSION| (e) | P=0.341 | |COCH-ARM / FISHERS | (e) | P=0.318 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Basophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/99 (2%) | 2/98 (2%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 2.2% | 2.2% 1.1% | |TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 2/70 (3%) 1/77 (1%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.233 | P=0.467N | |POLY 3 | P=0.235 | P=0.495N | |POLY 1.5 | P=0.236 | P=0.492N | |POLY 6 | P=0.234 | P=0.500N | |LOGISTIC REGRESSION| P=0.233 | P=0.467N | |COCH-ARM / FISHERS | P=0.246 | P=0.492N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 25 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Clear Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/100 (14%) 14/99 (14%) | 4/98 (4%) 5/100 (5%) | |POLY-3 ADJUSTED (b)| 15.0% 15.6% | 4.5% 5.5% | |TERMINAL (d) | 13/76 (17%) 13/74 (18%) | 3/70 (4%) 3/77 (4%) | |FIRST INCIDENCE | 520 582 | 608 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.551 | P=0.540 | |POLY 3 | P=0.543 | P=0.507 | |POLY 1.5 | P=0.553 | P=0.510 | |POLY 6 | P=0.534 | P=0.503 | |LOGISTIC REGRESSION| P=0.542 | P=0.512 | |COCH-ARM / FISHERS | P=0.569 | P=0.513 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Eosinophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 12/100 (12%) 16/99 (16%) | 6/98 (6%) 9/100 (9%) | |POLY-3 ADJUSTED (b)| 12.9% 17.7% | 6.6% 10.0% | |TERMINAL (d) | 10/76 (13%) 14/74 (19%) | 5/70 (7%) 9/77 (12%) | |FIRST INCIDENCE | 520 505 | 397 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247 | P=0.360 | |POLY 3 | P=0.243 | P=0.296 | |POLY 1.5 | P=0.250 | P=0.303 | |POLY 6 | P=0.236 | P=0.288 | |LOGISTIC REGRESSION| P=0.250 | P=0.308 | |COCH-ARM / FISHERS | P=0.261 | P=0.311 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 26 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Infiltration Cellular Focal Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 11/99 (11%) | 53/98 (54%) 51/100 (51%) | |POLY-3 ADJUSTED (b)| 6.5% 12.3% | 58.9% 55.2% | |TERMINAL (d) | 6/76 (8%) 11/74 (15%) | 47/70 (67%) 46/77 (60%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 666 534 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.139 | P=0.210N | |POLY 3 | P=0.138 | P=0.362N | |POLY 1.5 | P=0.143 | P=0.363N | |POLY 6 | P=0.134 | P=0.369N | |LOGISTIC REGRESSION| P=0.139 | P=0.447N | |COCH-ARM / FISHERS | P=0.150 | P=0.385N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Mixed Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/100 (4%) 3/99 (3%) | 0/98 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 4.3% 3.4% | 0.0% 0.0% | |TERMINAL (d) | 4/76 (5%) 3/74 (4%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.514N | (e) | |POLY 3 | P=0.521N | (e) | |POLY 1.5 | P=0.515N | (e) | |POLY 6 | P=0.526N | (e) | |LOGISTIC REGRESSION| P=0.514N | (e) | |COCH-ARM / FISHERS | P=0.506N | (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 27 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/100 (7%) 3/99 (3%) | 4/98 (4%) 5/100 (5%) | |POLY-3 ADJUSTED (b)| 7.4% 3.3% | 4.4% 5.4% | |TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 0/70 (0%) 2/77 (3%) | |FIRST INCIDENCE | 520 582 | 432 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.187N | P=0.508 | |POLY 3 | P=0.187N | P=0.508 | |POLY 1.5 | P=0.180N | P=0.511 | |POLY 6 | P=0.195N | P=0.501 | |LOGISTIC REGRESSION| P=0.115N | P=0.459 | |COCH-ARM / FISHERS | P=0.170N | P=0.513 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver: Hepatocyte | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 5/99 (5%) | 14/98 (14%) 14/100 (14%) | |POLY-3 ADJUSTED (b)| 13.7% 5.5% | 14.9% 15.2% | |TERMINAL (d) | 8/76 (11%) 2/74 (3%) | 6/70 (9%) 10/77 (13%) | |FIRST INCIDENCE | 386 415 | 288 534 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.052N | P=0.518N | |POLY 3 | P=0.050N | P=0.563 | |POLY 1.5 | P=0.048N* | P=0.578 | |POLY 6 | P=0.053N | P=0.547 | |LOGISTIC REGRESSION| P=0.020N* | P=0.572N | |COCH-ARM / FISHERS | P=0.043N* | P=0.558N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 28 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 20/100 (20%) 16/99 (16%) | 32/95 (34%) 30/100 (30%) | |POLY-3 ADJUSTED (b)| 21.5% 17.8% | 36.5% 32.1% | |TERMINAL (d) | 19/76 (25%) 15/74 (20%) | 30/70 (43%) 23/77 (30%) | |FIRST INCIDENCE | 497 620 | 667 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.318N | P=0.296N | |POLY 3 | P=0.333N | P=0.318N | |POLY 1.5 | P=0.321N | P=0.326N | |POLY 6 | P=0.342N | P=0.314N | |LOGISTIC REGRESSION| P=0.335N | P=0.363N | |COCH-ARM / FISHERS | P=0.302N | P=0.345N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Alveolar Epithelium | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 2/99 (2%) | 4/95 (4%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 2.2% 2.2% | 4.5% 1.1% | |TERMINAL (d) | 2/76 (3%) 2/74 (3%) | 3/70 (4%) 1/77 (1%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 432 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.684 | P=0.160N | |POLY 3 | P=0.684 | P=0.173N | |POLY 1.5 | P=0.686 | P=0.169N | |POLY 6 | P=0.682 | P=0.178N | |LOGISTIC REGRESSION| P=0.684 | P=0.163N | |COCH-ARM / FISHERS | P=0.686 | P=0.169N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 29 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Alveolus | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 9/99 (9%) | 1/95 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.2% 10.0% | 1.1% 0.0% | |TERMINAL (d) | 2/76 (3%) 8/74 (11%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 715 668 | 723 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.062 | P=0.500N | |POLY 3 | P=0.060 | P=0.486N | |POLY 1.5 | P=0.062 | P=0.483N | |POLY 6 | P=0.058 | P=0.491N | |LOGISTIC REGRESSION| P=0.058 | P=0.494N | |COCH-ARM / FISHERS | P=0.065 | P=0.487N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Artery | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/99 (0%) | 2/95 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | --- --- | 625 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.241N | |POLY 3 | (e) | P=0.229N | |POLY 1.5 | (e) | P=0.225N | |POLY 6 | (e) | P=0.234N | |LOGISTIC REGRESSION| (e) | P=0.224N | |COCH-ARM / FISHERS | (e) | P=0.236N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 30 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/92 (4%) 1/90 (1%) | 3/84 (4%) 3/92 (3%) | |POLY-3 ADJUSTED (b)| 4.6% 1.2% | 3.8% 3.6% | |TERMINAL (d) | 1/72 (1%) 1/69 (1%) | 0/66 (0%) 2/70 (3%) | |FIRST INCIDENCE | 582 734 (T) | 707 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.196N | P=0.643N | |POLY 3 | P=0.205N | P=0.630N | |POLY 1.5 | P=0.199N | P=0.622N | |POLY 6 | P=0.212N | P=0.641N | |LOGISTIC REGRESSION| P=0.170N | P=0.627N | |COCH-ARM / FISHERS | P=0.191N | P=0.615N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 1/90 (1%) | 2/84 (2%) 3/92 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% | 2.6% 3.6% | |TERMINAL (d) | 0/72 (0%) 1/69 (1%) | 2/66 (3%) 1/70 (1%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.492 | P=0.514 | |POLY 3 | P=0.500 | P=0.522 | |POLY 1.5 | P=0.500 | P=0.527 | |POLY 6 | P=0.500 | P=0.517 | |LOGISTIC REGRESSION| P=0.492 | P=0.545 | |COCH-ARM / FISHERS | P=0.495 | P=0.543 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 31 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/92 (1%) 3/90 (3%) | 8/84 (10%) 4/92 (4%) | |POLY-3 ADJUSTED (b)| 1.2% 3.7% | 10.2% 4.8% | |TERMINAL (d) | 1/72 (1%) 3/69 (4%) | 8/66 (12%) 4/70 (6%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.292 | P=0.156N | |POLY 3 | P=0.293 | P=0.157N | |POLY 1.5 | P=0.296 | P=0.150N | |POLY 6 | P=0.291 | P=0.166N | |LOGISTIC REGRESSION| P=0.292 | P=0.156N | |COCH-ARM / FISHERS | P=0.302 | P=0.144N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hyperplasia Reticulum Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 0/90 (0%) | 0/84 (0%) 2/92 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.4% | |TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 0/66 (0%) 2/70 (3%) | |FIRST INCIDENCE | --- --- | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.252 | |POLY 3 | (e) | P=0.244 | |POLY 1.5 | (e) | P=0.246 | |POLY 6 | (e) | P=0.242 | |LOGISTIC REGRESSION| (e) | P=0.252 | |COCH-ARM / FISHERS | (e) | P=0.272 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 32 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 3/90 (3%) | 0/84 (0%) 0/92 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 3.6% | 0.0% 0.0% | |TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 0/66 (0%) 0/70 (0%) | |FIRST INCIDENCE | --- 547 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.121 | (e) | |POLY 3 | P=0.118 | (e) | |POLY 1.5 | P=0.118 | (e) | |POLY 6 | P=0.118 | (e) | |LOGISTIC REGRESSION| P=0.161 | (e) | |COCH-ARM / FISHERS | P=0.119 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/92 (4%) 1/90 (1%) | 2/84 (2%) 1/92 (1%) | |POLY-3 ADJUSTED (b)| 4.7% 1.2% | 2.6% 1.2% | |TERMINAL (d) | 2/72 (3%) 0/69 (0%) | 2/66 (3%) 0/70 (0%) | |FIRST INCIDENCE | 705 729 | 735 (T) 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.198N | P=0.488N | |POLY 3 | P=0.202N | P=0.473N | |POLY 1.5 | P=0.197N | P=0.466N | |POLY 6 | P=0.206N | P=0.481N | |LOGISTIC REGRESSION| P=0.200N | P=0.468N | |COCH-ARM / FISHERS | P=0.191N | P=0.466N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 33 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Plasma Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 1/90 (1%) | 2/84 (2%) 1/92 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% | 2.6% 1.2% | |TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 2/66 (3%) 1/70 (1%) | |FIRST INCIDENCE | --- 581 | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.496 | P=0.480N | |POLY 3 | P=0.500 | P=0.475N | |POLY 1.5 | P=0.500 | P=0.467N | |POLY 6 | P=0.500 | P=0.484N | |LOGISTIC REGRESSION| P=0.547 | P=0.480N | |COCH-ARM / FISHERS | P=0.495 | P=0.466N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/92 (2%) 4/90 (4%) | 22/84 (26%) 18/92 (20%) | |POLY-3 ADJUSTED (b)| 2.3% 4.9% | 27.9% 21.7% | |TERMINAL (d) | 1/72 (1%) 2/69 (3%) | 18/66 (27%) 17/70 (24%) | |FIRST INCIDENCE | 603 666 | 667 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.320 | P=0.236N | |POLY 3 | P=0.320 | P=0.228N | |POLY 1.5 | P=0.324 | P=0.211N | |POLY 6 | P=0.317 | P=0.254N | |LOGISTIC REGRESSION| P=0.347 | P=0.259N | |COCH-ARM / FISHERS | P=0.331 | P=0.193N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 34 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/87 (7%) 12/92 (13%) | 12/83 (14%) 22/95 (23%) | |POLY-3 ADJUSTED (b)| 7.3% 13.9% | 15.0% 25.1% | |TERMINAL (d) | 3/70 (4%) 8/72 (11%) | 9/68 (13%) 17/74 (23%) | |FIRST INCIDENCE | 497 553 | 667 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.114 | P=0.071 | |POLY 3 | P=0.122 | P=0.075 | |POLY 1.5 | P=0.125 | P=0.083 | |POLY 6 | P=0.119 | P=0.066 | |LOGISTIC REGRESSION| P=0.144 | P=0.088 | |COCH-ARM / FISHERS | P=0.132 | P=0.099 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Ectasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 0/92 (0%) | 3/83 (4%) 0/95 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.8% 0.0% | |TERMINAL (d) | 0/70 (0%) 0/72 (0%) | 3/68 (4%) 0/74 (0%) | |FIRST INCIDENCE | --- --- | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.108N | |POLY 3 | (e) | P=0.102N | |POLY 1.5 | (e) | P=0.098N | |POLY 6 | (e) | P=0.107N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.099N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 35 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/87 (3%) 5/92 (5%) | 3/83 (4%) 2/95 (2%) | |POLY-3 ADJUSTED (b)| 3.7% 5.9% | 3.8% 2.3% | |TERMINAL (d) | 2/70 (3%) 5/72 (7%) | 3/68 (4%) 1/74 (1%) | |FIRST INCIDENCE | 684 734 (T) | 735 (T) 623 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.367 | P=0.469N | |POLY 3 | P=0.376 | P=0.452N | |POLY 1.5 | P=0.380 | P=0.442N | |POLY 6 | P=0.371 | P=0.464N | |LOGISTIC REGRESSION| P=0.375 | P=0.440N | |COCH-ARM / FISHERS | P=0.392 | P=0.436N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 3/92 (3%) | 2/83 (2%) 2/95 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 3.5% | 2.5% 2.3% | |TERMINAL (d) | 0/70 (0%) 3/72 (4%) | 2/68 (3%) 2/74 (3%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.127 | P=0.663N | |POLY 3 | P=0.126 | P=0.655N | |POLY 1.5 | P=0.127 | P=0.645N | |POLY 6 | P=0.125 | P=0.666N | |LOGISTIC REGRESSION| P=0.127 | P=0.663N | |COCH-ARM / FISHERS | P=0.134 | P=0.637N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 36 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hyperplasia Reticulum Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 0/92 (0%) | 3/83 (4%) 15/95 (16%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.8% 17.4% | |TERMINAL (d) | 0/70 (0%) 0/72 (0%) | 3/68 (4%) 14/74 (19%) | |FIRST INCIDENCE | --- --- | 735 (T) 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.005 ** | |POLY 3 | (e) | P=0.004 ** | |POLY 1.5 | (e) | P=0.005 ** | |POLY 6 | (e) | P=0.004 ** | |LOGISTIC REGRESSION| (e) | P=0.004 ** | |COCH-ARM / FISHERS | (e) | P=0.006 ** | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 59/87 (68%) 72/92 (78%) | 50/83 (60%) 41/95 (43%) | |POLY-3 ADJUSTED (b)| 70.4% 81.4% | 61.7% 46.7% | |TERMINAL (d) | 50/70 (71%) 60/72 (83%) | 44/68 (65%) 37/74 (50%) | |FIRST INCIDENCE | 520 533 | 397 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.055 | P=0.044N* | |POLY 3 | P=0.059 | P=0.032N* | |POLY 1.5 | P=0.065 | P=0.024N* | |POLY 6 | P=0.056 | P=0.045N* | |LOGISTIC REGRESSION| P=0.054 | P=0.031N* | |COCH-ARM / FISHERS | P=0.080 | P=0.017N* | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 37 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/87 (3%) 6/92 (7%) | 4/83 (5%) 5/95 (5%) | |POLY-3 ADJUSTED (b)| 3.7% 7.1% | 5.0% 5.8% | |TERMINAL (d) | 3/70 (4%) 5/72 (7%) | 4/68 (6%) 5/74 (7%) | |FIRST INCIDENCE | 734 (T) 716 | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.258 | P=0.552 | |POLY 3 | P=0.264 | P=0.545 | |POLY 1.5 | P=0.267 | P=0.556 | |POLY 6 | P=0.261 | P=0.532 | |LOGISTIC REGRESSION| P=0.259 | P=0.552 | |COCH-ARM / FISHERS | P=0.277 | P=0.584 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Plasma Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 1/92 (1%) | 5/83 (6%) 6/95 (6%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% | 6.3% 6.9% | |TERMINAL (d) | 0/70 (0%) 1/72 (1%) | 5/68 (7%) 5/74 (7%) | |FIRST INCIDENCE | --- 734 (T) | 735 (T) 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.506 | P=0.552 | |POLY 3 | P=0.500 | P=0.553 | |POLY 1.5 | P=0.500 | P=0.565 | |POLY 6 | P=0.500 | P=0.540 | |LOGISTIC REGRESSION| P=0.506 | P=0.547 | |COCH-ARM / FISHERS | P=0.514 | P=0.593 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 38 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node: Lumbar | | Ectasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/6 (0%) 0/7 (0%) | 3/19 (16%) 0/12 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 16.8% 0.0% | |TERMINAL (d) | 0/6 (0%) 0/3 (0%) | 3/11 (27%) 0/7 (0%) | |FIRST INCIDENCE | --- --- | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.200N | |POLY 3 | (e) | P=0.291N | |POLY 1.5 | (e) | P=0.271N | |POLY 6 | (e) | P=0.319N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.216N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node: Lumbar | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/6 (17%) 0/7 (0%) | 4/19 (21%) 0/12 (0%) | |POLY-3 ADJUSTED (b)| 16.7% 0.0% | 22.3% 0.0% | |TERMINAL (d) | 1/6 (17%) 0/3 (0%) | 4/11 (36%) 0/7 (0%) | |FIRST INCIDENCE | 734 (T) --- | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.638N | P=0.116N | |POLY 3 | P=0.534N | P=0.183N | |POLY 1.5 | P=0.487N | P=0.167N | |POLY 6 | P=0.617N | P=0.207N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | P=0.462N | P=0.123N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 39 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/2 (0%) 0/1 (0%) | 3/94 (3%) 3/98 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 3.4% | |TERMINAL (d) | 0/1 (0%) 0/1 (0%) | 1/70 (1%) 2/76 (3%) | |FIRST INCIDENCE | --- --- | 702 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.644N | |POLY 3 | (e) | P=0.647N | |POLY 1.5 | (e) | P=0.641N | |POLY 6 | (e) | P=0.655N | |LOGISTIC REGRESSION| (e) | P=0.644N | |COCH-ARM / FISHERS | (e) | P=0.639N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland: Duct | | Dilatation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/2 (0%) 0/1 (0%) | 10/94 (11%) 12/98 (12%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 11.5% 13.4% | |TERMINAL (d) | 0/1 (0%) 0/1 (0%) | 6/70 (9%) 9/76 (12%) | |FIRST INCIDENCE | --- --- | 542 580 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.466 | |POLY 3 | (e) | P=0.436 | |POLY 1.5 | (e) | P=0.445 | |POLY 6 | (e) | P=0.424 | |LOGISTIC REGRESSION| (e) | P=0.449 | |COCH-ARM / FISHERS | (e) | P=0.452 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 40 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mesentery: Fat | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/13 (8%) 0/9 (0%) | 6/36 (17%) 14/53 (26%) | |POLY-3 ADJUSTED (b)| 8.1% 0.0% | 17.3% 28.7% | |TERMINAL (d) | 1/10 (10%) 0/5 (0%) | 4/24 (17%) 11/37 (30%) | |FIRST INCIDENCE | 734 (T) --- | 701 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.638N | P=0.172 | |POLY 3 | P=0.716N | P=0.160 | |POLY 1.5 | P=0.686N | P=0.173 | |POLY 6 | P=0.754N | P=0.144 | |LOGISTIC REGRESSION| (e) | P=0.201 | |COCH-ARM / FISHERS | P=0.591N | P=0.207 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mesentery: Fat | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/13 (85%) 7/9 (78%) | 22/36 (61%) 31/53 (58%) | |POLY-3 ADJUSTED (b)| 84.6% 90.5% | 62.5% 62.4% | |TERMINAL (d) | 8/10 (80%) 5/5 (100%) | 17/24 (71%) 24/37 (65%) | |FIRST INCIDENCE | 582 667 | 603 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.582 | P=0.563 | |POLY 3 | P=0.689 | P=0.574N | |POLY 1.5 | P=0.768 | P=0.533N | |POLY 6 | P=0.586 | P=0.535 | |LOGISTIC REGRESSION| P=0.617 | P=0.568 | |COCH-ARM / FISHERS | P=0.550N | P=0.490N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 41 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 7/100 (7%) | 0/99 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 1.1% 7.7% | 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 3/74 (4%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) 605 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.034 * | (e) | |POLY 3 | P=0.033 * | (e) | |POLY 1.5 | P=0.034 * | (e) | |POLY 6 | P=0.032 * | (e) | |LOGISTIC REGRESSION| P=0.037 * | (e) | |COCH-ARM / FISHERS | P=0.033 * | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 0/79 (0%) 3/96 (3%) | |POLY-3 ADJUSTED (b)| | 0.0% 3.4% | |TERMINAL (d) | | 0/65 (0%) 3/77 (4%) | |FIRST INCIDENCE | | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.154 | |POLY 3 | | P=0.141 | |POLY 1.5 | | P=0.143 | |POLY 6 | | P=0.138 | |LOGISTIC REGRESSION| | P=0.154 | |COCH-ARM / FISHERS | | P=0.163 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 42 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 4/79 (5%) 3/96 (3%) | |POLY-3 ADJUSTED (b)| | 5.4% 3.4% | |TERMINAL (d) | | 3/65 (5%) 1/77 (1%) | |FIRST INCIDENCE | | 703 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.454N | |POLY 3 | | P=0.396N | |POLY 1.5 | | P=0.390N | |POLY 6 | | P=0.404N | |LOGISTIC REGRESSION| | P=0.397N | |COCH-ARM / FISHERS | | P=0.393N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 22/79 (28%) 24/96 (25%) | |POLY-3 ADJUSTED (b)| | 29.4% 27.2% | |TERMINAL (d) | | 19/65 (29%) 23/77 (30%) | |FIRST INCIDENCE | | 542 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.458N | |POLY 3 | | P=0.442N | |POLY 1.5 | | P=0.421N | |POLY 6 | | P=0.470N | |LOGISTIC REGRESSION| | P=0.455N | |COCH-ARM / FISHERS | | P=0.399N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 43 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Infiltration Cellular Focal Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 0/98 (0%) | 7/87 (8%) 12/95 (13%) | |POLY-3 ADJUSTED (b)| 1.1% 0.0% | 8.5% 13.6% | |TERMINAL (d) | 1/76 (1%) 0/74 (0%) | 7/70 (10%) 12/77 (16%) | |FIRST INCIDENCE | 734 (T) --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.505N | P=0.224 | |POLY 3 | P=0.514N | P=0.207 | |POLY 1.5 | P=0.510N | P=0.214 | |POLY 6 | P=0.517N | P=0.198 | |LOGISTIC REGRESSION| (e) | P=0.224 | |COCH-ARM / FISHERS | P=0.503N | P=0.222 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 5/98 (5%) | 5/87 (6%) 5/95 (5%) | |POLY-3 ADJUSTED (b)| 1.1% 5.6% | 6.1% 5.7% | |TERMINAL (d) | 0/76 (0%) 5/74 (7%) | 3/70 (4%) 4/77 (5%) | |FIRST INCIDENCE | 717 734 (T) | 667 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.101 | P=0.583N | |POLY 3 | P=0.099 | P=0.578N | |POLY 1.5 | P=0.101 | P=0.571N | |POLY 6 | P=0.098 | P=0.587N | |LOGISTIC REGRESSION| P=0.096 | P=0.576N | |COCH-ARM / FISHERS | P=0.103 | P=0.570N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 44 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Lipomatosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 4/98 (4%) | 21/87 (24%) 33/95 (35%) | |POLY-3 ADJUSTED (b)| 1.1% 4.5% | 25.1% 36.9% | |TERMINAL (d) | 0/76 (0%) 3/74 (4%) | 16/70 (23%) 30/77 (39%) | |FIRST INCIDENCE | 717 553 | 334 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.176 | P=0.082 | |POLY 3 | P=0.175 | P=0.062 | |POLY 1.5 | P=0.177 | P=0.069 | |POLY 6 | P=0.174 | P=0.054 | |LOGISTIC REGRESSION| P=0.186 | P=0.080 | |COCH-ARM / FISHERS | P=0.181 | P=0.080 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 16/99 (16%) 28/98 (29%) | 12/87 (14%) 15/95 (16%) | |POLY-3 ADJUSTED (b)| 17.4% 31.5% | 14.6% 16.9% | |TERMINAL (d) | 15/76 (20%) 27/74 (37%) | 12/70 (17%) 13/77 (17%) | |FIRST INCIDENCE | 715 729 | 735 (T) 656 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.021 * | P=0.431 | |POLY 3 | P=0.020 * | P=0.418 | |POLY 1.5 | P=0.022 * | P=0.425 | |POLY 6 | P=0.017 * | P=0.408 | |LOGISTIC REGRESSION| P=0.018 * | P=0.398 | |COCH-ARM / FISHERS | P=0.027 * | P=0.434 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 45 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas: Acinus | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/98 (2%) | 0/87 (0%) 0/95 (0%) | |POLY-3 ADJUSTED (b)| 1.1% 2.2% | 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | 734 (T) 620 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.491 | (e) | |POLY 3 | P=0.493 | (e) | |POLY 1.5 | P=0.495 | (e) | |POLY 6 | P=0.492 | (e) | |LOGISTIC REGRESSION| P=0.504 | (e) | |COCH-ARM / FISHERS | P=0.496 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas: Acinus | | Cytoplasmic Alteration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 4/98 (4%) | 1/87 (1%) 5/95 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 4.4% | 1.2% 5.6% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 1/77 (1%) | |FIRST INCIDENCE | --- 579 | 735 (T) 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.062 | P=0.117 | |POLY 3 | P=0.062 | P=0.124 | |POLY 1.5 | P=0.062 | P=0.125 | |POLY 6 | P=0.062 | P=0.123 | |LOGISTIC REGRESSION| P=0.079 | P=0.102 | |COCH-ARM / FISHERS | P=0.059 | P=0.127 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 46 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas: Duct | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/98 (0%) | 1/87 (1%) 2/95 (2%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | 1.2% 2.3% | |TERMINAL (d) | 2/76 (3%) 0/74 (0%) | 1/70 (1%) 2/77 (3%) | |FIRST INCIDENCE | 734 (T) --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.245N | P=0.533 | |POLY 3 | P=0.250N | P=0.517 | |POLY 1.5 | P=0.247N | P=0.519 | |POLY 6 | P=0.253N | P=0.513 | |LOGISTIC REGRESSION| (e) | P=0.533 | |COCH-ARM / FISHERS | P=0.251N | P=0.533 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Parathyroid Gland | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/66 (2%) 1/67 (1%) | 11/63 (17%) 8/58 (14%) | |POLY-3 ADJUSTED (b)| 1.6% 1.6% | 18.3% 14.6% | |TERMINAL (d) | 1/48 (2%) 0/53 (0%) | 10/48 (21%) 4/46 (9%) | |FIRST INCIDENCE | 734 (T) 533 | 733 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.751N | P=0.334N | |POLY 3 | P=0.747N | P=0.390N | |POLY 1.5 | P=0.750N | P=0.388N | |POLY 6 | P=0.743N | P=0.394N | |LOGISTIC REGRESSION| P=0.733 | P=0.278N | |COCH-ARM / FISHERS | P=0.748N | P=0.382N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 47 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/83 (11%) 14/86 (16%) | 0/83 (0%) 4/93 (4%) | |POLY-3 ADJUSTED (b)| 11.5% 17.4% | 0.0% 4.7% | |TERMINAL (d) | 7/66 (11%) 11/67 (16%) | 0/67 (0%) 4/74 (5%) | |FIRST INCIDENCE | 617 667 | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.190 | P=0.078 | |POLY 3 | P=0.202 | P=0.073 | |POLY 1.5 | P=0.206 | P=0.074 | |POLY 6 | P=0.195 | P=0.072 | |LOGISTIC REGRESSION| P=0.203 | P=0.078 | |COCH-ARM / FISHERS | P=0.211 | P=0.076 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/83 (1%) 1/86 (1%) | 37/83 (45%) 35/93 (38%) | |POLY-3 ADJUSTED (b)| 1.3% 1.3% | 47.8% 39.9% | |TERMINAL (d) | 1/66 (2%) 1/67 (2%) | 35/67 (52%) 29/74 (39%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 691 449 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.758N | P=0.263N | |POLY 3 | P=0.752N | P=0.191N | |POLY 1.5 | P=0.750N | P=0.198N | |POLY 6 | P=0.756N | P=0.188N | |LOGISTIC REGRESSION| P=0.758N | P=0.234N | |COCH-ARM / FISHERS | P=0.743N | P=0.217N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 48 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Preputial Gland | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 25/98 (26%) 56/99 (57%) | | |POLY-3 ADJUSTED (b)| 27.0% 58.9% | | |TERMINAL (d) | 15/75 (20%) 38/74 (51%) | | |FIRST INCIDENCE | 624 533 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P<0.001 ** | | |POLY 3 | P<0.001 ** | | |POLY 1.5 | P<0.001 ** | | |POLY 6 | P<0.001 ** | | |LOGISTIC REGRESSION| P<0.001 ** | | |COCH-ARM / FISHERS | P<0.001 ** | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Preputial Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 84/98 (86%) 89/99 (90%) | | |POLY-3 ADJUSTED (b)| 87.6% 90.5% | | |TERMINAL (d) | 65/75 (87%) 65/74 (88%) | | |FIRST INCIDENCE | 386 415 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.230 | | |POLY 3 | P=0.331 | | |POLY 1.5 | P=0.292 | | |POLY 6 | P=0.386 | | |LOGISTIC REGRESSION| P=0.233 | | |COCH-ARM / FISHERS | P=0.249 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 49 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Preputial Gland | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 46/98 (47%) 61/99 (62%) | | |POLY-3 ADJUSTED (b)| 49.8% 66.0% | | |TERMINAL (d) | 39/75 (52%) 52/74 (70%) | | |FIRST INCIDENCE | 617 533 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.019 * | | |POLY 3 | P=0.016 * | | |POLY 1.5 | P=0.019 * | | |POLY 6 | P=0.013 * | | |LOGISTIC REGRESSION| P=0.015 * | | |COCH-ARM / FISHERS | P=0.027 * | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 6/92 (7%) | | |POLY-3 ADJUSTED (b)| 2.2% 7.2% | | |TERMINAL (d) | 1/76 (1%) 6/71 (9%) | | |FIRST INCIDENCE | 684 734 (T) | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.119 | | |POLY 3 | P=0.115 | | |POLY 1.5 | P=0.118 | | |POLY 6 | P=0.113 | | |LOGISTIC REGRESSION| P=0.111 | | |COCH-ARM / FISHERS | P=0.120 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 50 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 49/98 (50%) 45/92 (49%) | | |POLY-3 ADJUSTED (b)| 52.9% 52.9% | | |TERMINAL (d) | 47/76 (62%) 39/71 (55%) | | |FIRST INCIDENCE | 386 630 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.503N | | |POLY 3 | P=0.561 | | |POLY 1.5 | P=0.548N | | |POLY 6 | P=0.562N | | |LOGISTIC REGRESSION| P=0.549 | | |COCH-ARM / FISHERS | P=0.498N | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Salivary Glands | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 66/99 (67%) 69/99 (70%) | 74/94 (79%) 79/99 (80%) | |POLY-3 ADJUSTED (b)| 70.1% 73.4% | 80.9% 81.9% | |TERMINAL (d) | 58/76 (76%) 58/74 (78%) | 60/70 (86%) 64/77 (83%) | |FIRST INCIDENCE | 520 415 | 334 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.281 | P=0.509N | |POLY 3 | P=0.366 | P=0.500 | |POLY 1.5 | P=0.371 | P=0.511 | |POLY 6 | P=0.364 | P=0.479 | |LOGISTIC REGRESSION| P=0.287 | P=0.487 | |COCH-ARM / FISHERS | P=0.380 | P=0.497 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 51 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Seminal Vesicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 80/99 (81%) 58/98 (59%) | | |POLY-3 ADJUSTED (b)| 82.9% 62.8% | | |TERMINAL (d) | 65/76 (86%) 46/74 (62%) | | |FIRST INCIDENCE | 386 415 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.006N** | | |POLY 3 | P<0.001N** | | |POLY 1.5 | P<0.001N** | | |POLY 6 | P<0.001N** | | |LOGISTIC REGRESSION| P<0.001N** | | |COCH-ARM / FISHERS | P<0.001N** | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Seminal Vesicle | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/98 (0%) | | |POLY-3 ADJUSTED (b)| 2.2% 0.0% | | |TERMINAL (d) | 2/76 (3%) 0/74 (0%) | | |FIRST INCIDENCE | 734 (T) --- | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.245N | | |POLY 3 | P=0.252N | | |POLY 1.5 | P=0.248N | | |POLY 6 | P=0.256N | | |LOGISTIC REGRESSION| (e) | | |COCH-ARM / FISHERS | P=0.251N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 52 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Ulcer Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/100 (1%) | 2/99 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% | 2.2% 0.0% | |TERMINAL (d) | 0/76 (0%) 1/74 (1%) | 1/70 (1%) 0/77 (0%) | |FIRST INCIDENCE | --- 734 (T) | 691 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.495 | P=0.236N | |POLY 3 | P=0.500 | P=0.237N | |POLY 1.5 | P=0.500 | P=0.235N | |POLY 6 | P=0.500 | P=0.240N | |LOGISTIC REGRESSION| P=0.495 | P=0.237N | |COCH-ARM / FISHERS | P=0.503 | P=0.246N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 37/99 (37%) 48/98 (49%) | 74/91 (81%) 92/99 (93%) | |POLY-3 ADJUSTED (b)| 39.2% 50.7% | 84.2% 94.4% | |TERMINAL (d) | 29/76 (38%) 34/74 (46%) | 63/70 (90%) 76/77 (99%) | |FIRST INCIDENCE | 386 456 | 397 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.072 | P=0.038 * | |POLY 3 | P=0.071 | P=0.015 * | |POLY 1.5 | P=0.068 | P=0.015 * | |POLY 6 | P=0.076 | P=0.013 * | |LOGISTIC REGRESSION| P=0.071 | P=0.009 ** | |COCH-ARM / FISHERS | P=0.067 | P=0.014 * | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 53 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/98 (1%) | 17/91 (19%) 12/99 (12%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% | 20.0% 13.3% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 15/70 (21%) 9/77 (12%) | |FIRST INCIDENCE | --- 620 | 696 650 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.496 | P=0.153N | |POLY 3 | P=0.500 | P=0.158N | |POLY 1.5 | P=0.500 | P=0.152N | |POLY 6 | P=0.500 | P=0.166N | |LOGISTIC REGRESSION| P=0.511 | P=0.174N | |COCH-ARM / FISHERS | P=0.497 | P=0.146N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen: Lymphoid Follicle | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/99 (11%) 8/98 (8%) | 6/91 (7%) 3/99 (3%) | |POLY-3 ADJUSTED (b)| 11.6% 8.8% | 6.9% 3.3% | |TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 1/70 (1%) 1/77 (1%) | |FIRST INCIDENCE | 520 581 | 552 481 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.355N | P=0.245N | |POLY 3 | P=0.346N | P=0.220N | |POLY 1.5 | P=0.337N | P=0.213N | |POLY 6 | P=0.357N | P=0.231N | |LOGISTIC REGRESSION| P=0.269N | P=0.181N | |COCH-ARM / FISHERS | P=0.324N | P=0.209N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 54 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen: Lymphoid Follicle | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 21/99 (21%) 19/98 (19%) | 31/91 (34%) 40/99 (40%) | |POLY-3 ADJUSTED (b)| 22.8% 21.3% | 36.5% 44.2% | |TERMINAL (d) | 20/76 (26%) 19/74 (26%) | 31/70 (44%) 39/77 (51%) | |FIRST INCIDENCE | 683 734 (T) | 735 (T) 534 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.469N | P=0.224 | |POLY 3 | P=0.473N | P=0.185 | |POLY 1.5 | P=0.460N | P=0.202 | |POLY 6 | P=0.488N | P=0.166 | |LOGISTIC REGRESSION| P=0.490N | P=0.138 | |COCH-ARM / FISHERS | P=0.444N | P=0.226 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen: Red Pulp | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 4/98 (4%) | 2/91 (2%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 4.4% | 2.3% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) | |FIRST INCIDENCE | --- 581 | 542 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.062 | P=0.236N | |POLY 3 | P=0.062 | P=0.222N | |POLY 1.5 | P=0.062 | P=0.217N | |POLY 6 | P=0.062 | P=0.228N | |LOGISTIC REGRESSION| P=0.068 | P=0.206N | |COCH-ARM / FISHERS | P=0.059 | P=0.228N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 55 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach: Epithelium | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/99 (9%) 8/99 (8%) | 6/91 (7%) 6/97 (6%) | |POLY-3 ADJUSTED (b)| 9.8% 8.9% | 7.0% 6.7% | |TERMINAL (d) | 8/76 (11%) 6/74 (8%) | 4/70 (6%) 6/77 (8%) | |FIRST INCIDENCE | 715 680 | 701 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.529N | P=0.565N | |POLY 3 | P=0.522N | P=0.579N | |POLY 1.5 | P=0.514N | P=0.573N | |POLY 6 | P=0.530N | P=0.590N | |LOGISTIC REGRESSION| P=0.535N | P=0.591N | |COCH-ARM / FISHERS | P=0.500N | P=0.571N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/99 (1%) | 4/91 (4%) 5/97 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% | 4.7% 5.6% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 4/70 (6%) 4/77 (5%) | |FIRST INCIDENCE | --- 630 | 735 (T) 701 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.496 | P=0.550 | |POLY 3 | P=0.500 | P=0.530 | |POLY 1.5 | P=0.500 | P=0.533 | |POLY 6 | P=0.500 | P=0.524 | |LOGISTIC REGRESSION| P=0.529 | P=0.521 | |COCH-ARM / FISHERS | P=0.500 | P=0.540 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 56 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/94 (0%) 0/93 (0%) | 7/86 (8%) 5/94 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 8.6% 5.8% | |TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 7/70 (10%) 5/77 (7%) | |FIRST INCIDENCE | --- --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.318N | |POLY 3 | (e) | P=0.339N | |POLY 1.5 | (e) | P=0.330N | |POLY 6 | (e) | P=0.352N | |LOGISTIC REGRESSION| (e) | P=0.318N | |COCH-ARM / FISHERS | (e) | P=0.323N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular: Epithelium | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/94 (9%) 10/93 (11%) | 14/86 (16%) 28/94 (30%) | |POLY-3 ADJUSTED (b)| 9.0% 11.4% | 16.7% 31.9% | |TERMINAL (d) | 7/76 (9%) 6/74 (8%) | 8/70 (11%) 24/77 (31%) | |FIRST INCIDENCE | 715 547 | 334 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.377 | P=0.026 * | |POLY 3 | P=0.392 | P=0.015 * | |POLY 1.5 | P=0.393 | P=0.018 * | |POLY 6 | P=0.391 | P=0.013 * | |LOGISTIC REGRESSION| P=0.392 | P=0.027 * | |COCH-ARM / FISHERS | P=0.393 | P=0.024 * | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 57 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular: Epithelium | | Cyst Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/94 (6%) 11/93 (12%) | 23/86 (27%) 20/94 (21%) | |POLY-3 ADJUSTED (b)| 6.8% 12.7% | 28.0% 22.9% | |TERMINAL (d) | 6/76 (8%) 10/74 (14%) | 20/70 (29%) 19/77 (25%) | |FIRST INCIDENCE | 734 (T) 668 | 608 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.140 | P=0.250N | |POLY 3 | P=0.143 | P=0.278N | |POLY 1.5 | P=0.146 | P=0.262N | |POLY 6 | P=0.141 | P=0.304N | |LOGISTIC REGRESSION| P=0.136 | P=0.278N | |COCH-ARM / FISHERS | P=0.149 | P=0.247N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Testes | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 2/98 (2%) | | |POLY-3 ADJUSTED (b)| 3.3% 2.2% | | |TERMINAL (d) | 1/76 (1%) 0/74 (0%) | | |FIRST INCIDENCE | 684 605 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.524N | | |POLY 3 | P=0.517N | | |POLY 1.5 | P=0.513N | | |POLY 6 | P=0.521N | | |LOGISTIC REGRESSION| P=0.483N | | |COCH-ARM / FISHERS | P=0.505N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 58 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/69 (0%) 0/60 (0%) | 1/78 (1%) 2/89 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.4% 2.4% | |TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 1/62 (2%) 2/71 (3%) | |FIRST INCIDENCE | --- --- | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.547 | |POLY 3 | (e) | P=0.526 | |POLY 1.5 | (e) | P=0.528 | |POLY 6 | (e) | P=0.523 | |LOGISTIC REGRESSION| (e) | P=0.547 | |COCH-ARM / FISHERS | (e) | P=0.550 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 62/69 (90%) 44/60 (73%) | 22/78 (28%) 27/89 (30%) | |POLY-3 ADJUSTED (b)| 90.1% 74.3% | 29.5% 31.2% | |TERMINAL (d) | 48/54 (89%) 32/46 (70%) | 14/62 (23%) 16/71 (23%) | |FIRST INCIDENCE | 386 415 | 608 309 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.060N | P=0.380 | |POLY 3 | P=0.016N* | P=0.471 | |POLY 1.5 | P=0.014N* | P=0.466 | |POLY 6 | P=0.018N* | P=0.469 | |LOGISTIC REGRESSION| P=0.013N* | P=0.471 | |COCH-ARM / FISHERS | P=0.013N* | P=0.448 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 59 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Cyst Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/69 (6%) 5/60 (8%) | 5/78 (6%) 3/89 (3%) | |POLY-3 ADJUSTED (b)| 6.3% 9.1% | 6.8% 3.7% | |TERMINAL (d) | 4/54 (7%) 5/46 (11%) | 5/62 (8%) 3/71 (4%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.401 | P=0.287N | |POLY 3 | P=0.424 | P=0.292N | |POLY 1.5 | P=0.424 | P=0.287N | |POLY 6 | P=0.423 | P=0.299N | |LOGISTIC REGRESSION| P=0.401 | P=0.287N | |COCH-ARM / FISHERS | P=0.412 | P=0.289N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/69 (1%) 0/60 (0%) | 0/78 (0%) 2/89 (2%) | |POLY-3 ADJUSTED (b)| 1.6% 0.0% | 0.0% 2.4% | |TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 0/62 (0%) 2/71 (3%) | |FIRST INCIDENCE | 582 --- | --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.509N | P=0.269 | |POLY 3 | P=0.559N | P=0.250 | |POLY 1.5 | P=0.557N | P=0.252 | |POLY 6 | P=0.561N | P=0.249 | |LOGISTIC REGRESSION| P=0.533N | P=0.269 | |COCH-ARM / FISHERS | P=0.535N | P=0.283 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 60 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Hyperplasia Lymphoid | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/69 (4%) 5/60 (8%) | 31/78 (40%) 25/89 (28%) | |POLY-3 ADJUSTED (b)| 4.7% 9.1% | 42.4% 30.2% | |TERMINAL (d) | 2/54 (4%) 5/46 (11%) | 31/62 (50%) 23/71 (32%) | |FIRST INCIDENCE | 534 734 (T) | 735 (T) 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.282 | P=0.069N | |POLY 3 | P=0.289 | P=0.075N | |POLY 1.5 | P=0.291 | P=0.073N | |POLY 6 | P=0.287 | P=0.079N | |LOGISTIC REGRESSION| P=0.284 | P=0.097N | |COCH-ARM / FISHERS | P=0.284 | P=0.077N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus: Thymocyte | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/69 (0%) 0/60 (0%) | 0/78 (0%) 3/89 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 3.6% | |TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 0/62 (0%) 0/71 (0%) | |FIRST INCIDENCE | --- --- | --- 458 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.125 | |POLY 3 | (e) | P=0.136 | |POLY 1.5 | (e) | P=0.137 | |POLY 6 | (e) | P=0.135 | |LOGISTIC REGRESSION| (e) | P=0.144 | |COCH-ARM / FISHERS | (e) | P=0.149 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 61 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) | 2/92 (2%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 2.3% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 1/70 (1%) 2/75 (3%) | |FIRST INCIDENCE | --- --- | 461 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.673N | |POLY 3 | (e) | P=0.688N | |POLY 1.5 | (e) | P=0.679N | |POLY 6 | (e) | P=0.690 | |LOGISTIC REGRESSION| (e) | P=0.636N | |COCH-ARM / FISHERS | (e) | P=0.665N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: Follicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/99 (5%) 9/98 (9%) | 21/92 (23%) 37/98 (38%) | |POLY-3 ADJUSTED (b)| 5.4% 10.1% | 24.2% 41.2% | |TERMINAL (d) | 4/76 (5%) 6/72 (8%) | 20/70 (29%) 31/75 (41%) | |FIRST INCIDENCE | 718 579 | 701 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.182 | P=0.019 * | |POLY 3 | P=0.186 | P=0.011 * | |POLY 1.5 | P=0.190 | P=0.013 * | |POLY 6 | P=0.181 | P=0.009 ** | |LOGISTIC REGRESSION| P=0.188 | P=0.008 ** | |COCH-ARM / FISHERS | P=0.198 | P=0.019 * | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 62 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) | 3/92 (3%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 3/70 (4%) 0/75 (0%) | |FIRST INCIDENCE | --- --- | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.111N | |POLY 3 | (e) | P=0.117N | |POLY 1.5 | (e) | P=0.113N | |POLY 6 | (e) | P=0.121N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.112N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Urinary Bladder | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/98 (4%) 4/94 (4%) | 8/79 (10%) 5/92 (5%) | |POLY-3 ADJUSTED (b)| 4.4% 4.6% | 10.6% 5.9% | |TERMINAL (d) | 4/76 (5%) 4/74 (5%) | 8/67 (12%) 4/76 (5%) | |FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.627 | P=0.212N | |POLY 3 | P=0.611 | P=0.203N | |POLY 1.5 | P=0.615 | P=0.197N | |POLY 6 | P=0.608 | P=0.212N | |LOGISTIC REGRESSION| P=0.627 | P=0.225N | |COCH-ARM / FISHERS | P=0.616 | P=0.194N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 63 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 1/92 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| | 1.2% 3.3% | |TERMINAL (d) | | 1/70 (1%) 2/77 (3%) | |FIRST INCIDENCE | | 735 (T) 567 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.336 | |POLY 3 | | P=0.322 | |POLY 1.5 | | P=0.325 | |POLY 6 | | P=0.318 | |LOGISTIC REGRESSION| | P=0.345 | |COCH-ARM / FISHERS | | P=0.343 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Hydrometra | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 48/92 (52%) 48/100 (48%) | |POLY-3 ADJUSTED (b)| | 54.5% 50.5% | |TERMINAL (d) | | 38/70 (54%) 37/77 (48%) | |FIRST INCIDENCE | | 542 449 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.364N | |POLY 3 | | P=0.344N | |POLY 1.5 | | P=0.335N | |POLY 6 | | P=0.360N | |LOGISTIC REGRESSION| | P=0.358N | |COCH-ARM / FISHERS | | P=0.332N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 64 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 2/92 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| | 2.3% 0.0% | |TERMINAL (d) | | 2/70 (3%) 0/77 (0%) | |FIRST INCIDENCE | | 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.218N | |POLY 3 | | P=0.222N | |POLY 1.5 | | P=0.217N | |POLY 6 | | P=0.228N | |LOGISTIC REGRESSION| | (e) | |COCH-ARM / FISHERS | | P=0.228N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus: Endometrium | | Hyperplasia Cystic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 54/92 (59%) 62/100 (62%) | |POLY-3 ADJUSTED (b)| | 60.4% 65.8% | |TERMINAL (d) | | 43/70 (61%) 51/77 (66%) | |FIRST INCIDENCE | | 334 449 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.365 | |POLY 3 | | P=0.270 | |POLY 1.5 | | P=0.307 | |POLY 6 | | P=0.233 | |LOGISTIC REGRESSION| | P=0.337 | |COCH-ARM / FISHERS | | P=0.374 | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Poly-3 adjusted lifetime tumor incidence. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates For all tests a negative trend is indicated by N (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).