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TDMS Study 89029-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 01/06/98      
EXPERIMENT: 89029 TEST: 06                                                                                     TIME: 14:01:23      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029      
PATHOLOGIST: PLETCHER, J                                                                                       CAS: ELECTROMAG     
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 76        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      386   497   520   534   579   579   582   603   617   624                 |
 |      646   666   677   683   684   684   691   705   715   715                 |
 |      716   717   718   731                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 GAUSS INTER.                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 74        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      415   420   456   505   533   547   553   579   581   582                 |
 |      605   620   630   653   666   666   667   668   672   680                 |
 |      680   686   714   716   722   729                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0 100.0  99.0  99.0  96.0  92.0  89.0  76.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0  98.0  97.0  95.0  89.0  86.0  74.0      |
 |GAUSS INTER|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                SHAM                      10                    |
 |                                CONTROL                   GAUSS INTER.          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.0%                     74.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.783                   P=0.783               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.2                     613.3                 |
 |NATURAL DEATHS (C)      |       (17.8)                    (17.9)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       710.5                     702.6                 |
 |(STANDARD ERROR)        |       ( 5.9)                    ( 7.0)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = SHAM    CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 29     CENSORED DEATHS 1    TERMINAL 70        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      334   397   432   461   542   551   552   602   603   608                 |
 |      625   666   667   691   691   696   701   702   703   707                 |
 |      707   719   723   725   725   726   729   729   733                       |
 |  CENSORED DEATHS                                                               |
 |      288                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 GAUSS INTER.                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 77        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      309   449   458   481   534   567   567   567   576   580                 |
 |      607   623   639   650   656   656   673   679   679   701                 |
 |      704   710   715                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                               MAGNETIC FIELDS (EMF)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |SHAM       |   100.0 100.0 100.0  99.0  98.0  96.0  94.9  90.9  88.9  70.7      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0  99.0  99.0  96.0  95.0  90.0  84.0  77.0      |
 |GAUSS INTER|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                SHAM                      10                    |
 |                                CONTROL                   GAUSS INTER.          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.7%                     77.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.490N                  P=0.490N              |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.1                     599.1                 |
 |NATURAL DEATHS (C)      |       (20.7)                    (21.1)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       701.9                     703.8                 |
 |(STANDARD ERROR)        |       ( 8.5)                    ( 7.5)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        10 GAUSS INTER.  = 2

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100.0 +1                                                             1   2
        |
        |                                                              1               1
        |                                                                  2      2    1    1
   97.5 +
        |                                                                         2      2  1 1
        |                                                                                2    1     1
        |
   95.0 +                                                                                     2 2
        |
        |                                                                                           11
        |                                                                                       2   21   1
   92.5 +
        |                                                                                                1 1
P       |                                                                                           22     11
E       |
R  90.0 +                                                                                            2   2  1  1
C       |
E       |                                                                                                2 2   1   1
N       |                                                                                                  22      11
T  87.5 +
        |                                                                                                   2   2   11
S       |                                                                                                       2  2
U       |
R  85.0 +
V       |
I       |                                                                                                            11
V       |                                                                                                             1 1
A  82.5 +
L       |                                                                                                               1 1
        |                                                                                                          2 2
        |
   80.0 +
        |
        |
        |                                                                                                            2   2
   77.5 +
        |                                                                                                                21  1
        |                                                                                                                 22 1
        |
   75.0 +                                                                                                                  2 2
        |
        |                                                                                                                    2
        |
   72.5 +
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 3 obs hidden.
                                                       MAGNETIC FIELDS (EMF)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        SHAM    CONTROL  = 1
                                                        10 GAUSS INTER.  = 2

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                 2  1
      |                                                   2  1         1        2
      |                                                                1    1   21  2
      |                                                                          1  2        21
P  95 +                                                                                      211 2
E     |
R     |                                                                                        1 2 2   11
C     |
E  90 +                                                                                            2    1  1
N     |                                                                                                 2 21      1
T     |                                                                                                   2  22
      |                                                                                                       22  1  1
S  85 +                                                                                                              11
U     |                                                                                                        2   2  11
R     |
V     |                                                                                                            2   2
I  80 +
V     |                                                                                                                121
A     |                                                                                                                 211 2
L     |
   75 +
      |                                                                                                                   1 1
      |
      |                                                                                                                     1
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 10 obs hidden.