TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 14:01:23 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG MAGNETIC FIELDS (EMF) STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 734 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = SHAM CONTROL | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 76 | | | | UNCENSORED DEATHS | | 386 497 520 534 579 579 582 603 617 624 | | 646 666 677 683 684 684 691 705 715 715 | | 716 717 718 731 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 10 GAUSS INTER. | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 74 | | | | UNCENSORED DEATHS | | 415 420 456 505 533 547 553 579 581 582 | | 605 620 630 653 666 666 667 668 672 680 | | 680 686 714 716 722 729 | | CENSORED DEATHS | | NONE | | | ================================================================================== MAGNETIC FIELDS (EMF) STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 734 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 734 (A) | | | |--------------------------------------------------------------------------------| | | | |SHAM | 100.0 100.0 100.0 100.0 99.0 99.0 96.0 92.0 89.0 76.0 | |CONTROL | | | | | |10 | 100.0 100.0 100.0 100.0 98.0 97.0 95.0 89.0 86.0 74.0 | |GAUSS INTER| | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | SHAM 10 | | CONTROL GAUSS INTER. | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 76.0% 74.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.783 P=0.783 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 636.2 613.3 | |NATURAL DEATHS (C) | (17.8) (17.9) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 710.5 702.6 | |(STANDARD ERROR) | ( 5.9) ( 7.0) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) MAGNETIC FIELDS (EMF) STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 735 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = SHAM CONTROL | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 29 CENSORED DEATHS 1 TERMINAL 70 | | | | UNCENSORED DEATHS | | 334 397 432 461 542 551 552 602 603 608 | | 625 666 667 691 691 696 701 702 703 707 | | 707 719 723 725 725 726 729 729 733 | | CENSORED DEATHS | | 288 | | | |--------------------------------------------------------------------------------| | DOSE = 10 GAUSS INTER. | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 77 | | | | UNCENSORED DEATHS | | 309 449 458 481 534 567 567 567 576 580 | | 607 623 639 650 656 656 673 679 679 701 | | 704 710 715 | | CENSORED DEATHS | | NONE | | | ================================================================================== MAGNETIC FIELDS (EMF) STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 735 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 735 (A) | | | |--------------------------------------------------------------------------------| | | | |SHAM | 100.0 100.0 100.0 99.0 98.0 96.0 94.9 90.9 88.9 70.7 | |CONTROL | | | | | |10 | 100.0 100.0 100.0 99.0 99.0 96.0 95.0 90.0 84.0 77.0 | |GAUSS INTER| | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | SHAM 10 | | CONTROL GAUSS INTER. | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 70.7% 77.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.490N P=0.490N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 636.1 599.1 | |NATURAL DEATHS (C) | (20.7) (21.1) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 701.9 703.8 | |(STANDARD ERROR) | ( 8.5) ( 7.5) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) MAGNETIC FIELDS (EMF) KAPLAN-MEIER SURVIVAL CURVES SHAM CONTROL = 1 10 GAUSS INTER. = 2 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. 100.0 +1 1 2 | | 1 1 | 2 2 1 1 97.5 + | 2 2 1 1 | 2 1 1 | 95.0 + 2 2 | | 11 | 2 21 1 92.5 + | 1 1 P | 22 11 E | R 90.0 + 2 2 1 1 C | E | 2 2 1 1 N | 22 11 T 87.5 + | 2 2 11 S | 2 2 U | R 85.0 + V | I | 11 V | 1 1 A 82.5 + L | 1 1 | 2 2 | 80.0 + | | | 2 2 77.5 + | 21 1 | 22 1 | 75.0 + 2 2 | | 2 | 72.5 + -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 3 obs hidden. MAGNETIC FIELDS (EMF) KAPLAN-MEIER SURVIVAL CURVES SHAM CONTROL = 1 10 GAUSS INTER. = 2 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | 2 1 1 2 | 1 1 21 2 | 1 2 21 P 95 + 211 2 E | R | 1 2 2 11 C | E 90 + 2 1 1 N | 2 21 1 T | 2 22 | 22 1 1 S 85 + 11 U | 2 2 11 R | V | 2 2 I 80 + V | 121 A | 211 2 L | 75 + | 1 1 | | 1 70 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 10 obs hidden.