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TDMS Study 89029-11 Pathology Tables

NTP Experiment-Test: 89029-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32


                               10(10MGX1)DMBA V 50HZ/1G 10(10MGX1)DMBA V 50HZ/5G 10(10MGX1)DMBA V 60HZ/1G 10 10(10MGX1)DMBA

       Facility:  Battelle Northwest

       Chemical CAS #:  EMF + DMBA

       Lock Date:  10/14/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    10 DMBA CONTROL
                               Include 003    50 HZ/1G 10 DMBA
                               Include 004    60 HZ/1G 10 DMBA
                               Include 005    50 HZ/5G 10 DMBA

































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 89029-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT0
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98  
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL       10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                         100          100          100          100                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6           11            4            3                                     
    Moribund Sacrifice                                 6            4            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                88           85           91           94                                     
  Animals Examined Microscopically                   100          100          100          100                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (98)         (99)         (100)        (100)                                  
      Hepatocellular Adenoma                           1 (1%)                                                                       
      Histiocytic Sarcoma                                           1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (3)          (3)                        (1)                                   
   Lymph Node, Mandibular                                                                     (1)                                   
____________________________________________________________________________________________________________________________________



                                                                                                                                    
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NTP Experiment-Test: 89029-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98  
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL       10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (100)        (100)        (100)        (100)                                  
      Adenoma                                          2 (2%)                                                                       
      Carcinoma                                        7 (7%)      16 (16%)     16 (16%)     15 (15%)                               
      Carcinoma, Multiple                             89 (89%)     74 (74%)     79 (79%)     70 (70%)                               
      Fibroadenoma                                    21 (21%)     24 (24%)     15 (15%)     24 (24%)                               
      Fibroadenoma, Multiple                          50 (50%)     52 (52%)     58 (58%)     44 (44%)                               
   Skin                                               (19)         (8)          (13)         (10)                                   
      Basal Cell Carcinoma                                          1 (13%)                                                         
      Squamous Cell Carcinoma                          1 (5%)                                                                       
      Trichoepithelioma                                6 (32%)      6 (75%)      10 (77%)     8 (80%)                               
      Subcutaneous Tissue, Fibroma                     1 (5%)                                                                       
      Subcutaneous Tissue, Hemangioma                                                         1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (98)         (100)        (100)        (100)                                  
      Carcinoma, Metastatic, Mammary Gland             4 (4%)       4 (4%)       1 (1%)       4 (4%)                                
      Histiocytic Sarcoma                                           1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (98)         (100)        (100)                                  
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Sarcoma                                          1 (1%)                                                                       



                                                             Page   3                                                               

NTP Experiment-Test: 89029-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98  
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL       10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Renal Tubule, Adenoma                                                    1 (1%)                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(100)       *(100)       *(100)       *(100)                                  
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Leukemia Mononuclear                             4 (4%)      10 (10%)      2 (2%)       6 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    




































     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               

NTP Experiment-Test: 89029-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98  
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL       10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            97          99          98          94                                       
     Total Primary Neoplasms                          197         195         185         175                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 74          77          74          70                                       
     Total Benign Neoplasms                            86          86          86          80                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              96          91          95          86                                       
     Total Malignant Neoplasms                        111         109          99          95                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4           1           4                                       
     Total Metastatic Neoplasm                          4           4           1           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              


























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