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TDMS Study 89029-11 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                        MAGNETIC FIELDS + DMBA INITIATION PROMOTION                     DATE: 01/07/98     
EXPERIMENT: 89029 TEST: 11                                                                                     TIME: 16:17:12     
TEST TYPE:  SUBCHRON 26-WEEK                    CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-65397                              ROUTE: MAGNETIC FIELDS                                         NTP C#: 89029D     
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: EMF+DMBA      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF    MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
===============================================================

Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Kidney                                 Mineralization
Liver                                  Basophilic Focus
Lung: Alveolar Epithelium              Hyperplasia
===============================================================
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/100 (1%)       1/98 (1%)        5/100 (5%)                                                         |
|POLY-3 ADJUSTED (b)|        1.1%             1.1%             5.2%                                                               |
|TERMINAL (d)       |        0/88 (0%)        0/85 (0%)        4/91 (4%)                                                          |
|FIRST INCIDENCE    |        173              134              176                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.045 *        P=0.749          P=0.115                                                            |
|POLY 3             |        P=0.040 *        P=0.754          P=0.108                                                            |
|POLY 1.5           |        P=0.040 *        P=0.755          P=0.107                                                            |
|POLY 6             |        P=0.041 *        P=0.752          P=0.109                                                            |
|LOGISTIC REGRESSION|        P=0.038 *        P=0.759N         P=0.108                                                            |
|COCH-ARM / FISHERS |        P=0.039 *        P=0.746          P=0.106                                                            |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/100 (24%)     15/98 (15%)      27/100 (27%)                                                       |
|POLY-3 ADJUSTED (b)|        25.1%            16.3%            27.9%                                                              |
|TERMINAL (d)       |        22/88 (25%)      13/85 (15%)      24/91 (26%)                                                        |
|FIRST INCIDENCE    |        113              164              89                                                                 |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.203          P=0.098N         P=0.423                                                            |
|POLY 3             |        P=0.180          P=0.096N         P=0.396                                                            |
|POLY 1.5           |        P=0.170          P=0.092N         P=0.387                                                            |
|POLY 6             |        P=0.190          P=0.100N         P=0.407                                                            |
|LOGISTIC REGRESSION|        P=0.161          P=0.092N         P=0.373                                                            |
|COCH-ARM / FISHERS |        P=0.158          P=0.087N         P=0.373                                                            |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/98 (6%)        3/99 (3%)        4/100 (4%)                                                         |
|POLY-3 ADJUSTED (b)|        6.4%             3.3%             4.2%                                                               |
|TERMINAL (d)       |        6/88 (7%)        3/85 (4%)        4/91 (4%)                                                          |
|FIRST INCIDENCE    |        183 (T)          183 (T)          183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.418N         P=0.264N         P=0.352N                                                           |
|POLY 3             |        P=0.429N         P=0.253N         P=0.360N                                                           |
|POLY 1.5           |        P=0.432N         P=0.249N         P=0.360N                                                           |
|POLY 6             |        P=0.424N         P=0.259N         P=0.359N                                                           |
|LOGISTIC REGRESSION|        P=0.418N         P=0.264N         P=0.352N                                                           |
|COCH-ARM / FISHERS |        P=0.437N         P=0.244N         P=0.361N                                                           |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/98 (4%)        3/99 (3%)        13/100 (13%)                                                       |
|POLY-3 ADJUSTED (b)|        4.3%             3.3%             13.6%                                                              |
|TERMINAL (d)       |        4/88 (5%)        3/85 (4%)        13/91 (14%)                                                        |
|FIRST INCIDENCE    |        183 (T)          183 (T)          183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.004 **       P=0.519N         P=0.025 *                                                          |
|POLY 3             |        P=0.003 **       P=0.506N         P=0.023 *                                                          |
|POLY 1.5           |        P=0.003 **       P=0.501N         P=0.022 *                                                          |
|POLY 6             |        P=0.003 **       P=0.513N         P=0.023 *                                                          |
|LOGISTIC REGRESSION|        P=0.004 **       P=0.519N         P=0.025 *                                                          |
|COCH-ARM / FISHERS |        P=0.003 **       P=0.494N         P=0.022 *                                                          |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/98 (8%)        11/99 (11%)      14/100 (14%)                                                       |
|POLY-3 ADJUSTED (b)|        8.6%             11.9%            14.7%                                                              |
|TERMINAL (d)       |        8/88 (9%)        11/85 (13%)      14/91 (15%)                                                        |
|FIRST INCIDENCE    |        183 (T)          183 (T)          183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.164          P=0.286          P=0.147                                                            |
|POLY 3             |        P=0.149          P=0.305          P=0.140                                                            |
|POLY 1.5           |        P=0.146          P=0.313          P=0.140                                                            |
|POLY 6             |        P=0.151          P=0.295          P=0.140                                                            |
|LOGISTIC REGRESSION|        P=0.164          P=0.286          P=0.147                                                            |
|COCH-ARM / FISHERS |        P=0.144          P=0.324          P=0.140                                                            |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/98 (1%)        2/99 (2%)        0/100 (0%)                                                         |
|POLY-3 ADJUSTED (b)|        1.1%             2.2%             0.0%                                                               |
|TERMINAL (d)       |        1/88 (1%)        2/85 (2%)        0/91 (0%)                                                          |
|FIRST INCIDENCE    |        183 (T)          183 (T)          ---                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.285N         P=0.488          P=0.493N                                                           |
|POLY 3             |        P=0.290N         P=0.496          P=0.496N                                                           |
|POLY 1.5           |        P=0.291N         P=0.499          P=0.496N                                                           |
|POLY 6             |        P=0.289N         P=0.492          P=0.496N                                                           |
|LOGISTIC REGRESSION|        P=0.285N         P=0.488          (e)                                                                |
|COCH-ARM / FISHERS |        P=0.291N         P=0.504          P=0.495N                                                           |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/98 (0%)        0/99 (0%)        2/100 (2%)                                                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.1%                                                               |
|TERMINAL (d)       |        0/88 (0%)        0/85 (0%)        1/91 (1%)                                                          |
|FIRST INCIDENCE    |        ---              ---              173                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.102          (e)              P=0.245                                                            |
|POLY 3             |        P=0.097          (e)              P=0.244                                                            |
|POLY 1.5           |        P=0.097          (e)              P=0.243                                                            |
|POLY 6             |        P=0.098          (e)              P=0.244                                                            |
|LOGISTIC REGRESSION|        P=0.097          (e)              P=0.243                                                            |
|COCH-ARM / FISHERS |        P=0.097          (e)              P=0.254                                                            |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/98 (7%)        5/99 (5%)        5/100 (5%)                                                         |
|POLY-3 ADJUSTED (b)|        7.5%             5.4%             5.2%                                                               |
|TERMINAL (d)       |        6/88 (7%)        4/85 (5%)        4/91 (4%)                                                          |
|FIRST INCIDENCE    |        176              131              138                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.379N         P=0.408N         P=0.364N                                                           |
|POLY 3             |        P=0.386N         P=0.387N         P=0.365N                                                           |
|POLY 1.5           |        P=0.391N         P=0.382N         P=0.367N                                                           |
|POLY 6             |        P=0.382N         P=0.395N         P=0.364N                                                           |
|LOGISTIC REGRESSION|        P=0.397N         P=0.376N         P=0.369N                                                           |
|COCH-ARM / FISHERS |        P=0.396N         P=0.377N         P=0.370N                                                           |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/98 (0%)        0/99 (0%)        2/100 (2%)                                                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.1%                                                               |
|TERMINAL (d)       |        0/88 (0%)        0/85 (0%)        1/91 (1%)                                                          |
|FIRST INCIDENCE    |        ---              ---              77                                                                 |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.099          (e)              P=0.243                                                            |
|POLY 3             |        P=0.098          (e)              P=0.246                                                            |
|POLY 1.5           |        P=0.098          (e)              P=0.245                                                            |
|POLY 6             |        P=0.099          (e)              P=0.246                                                            |
|LOGISTIC REGRESSION|        P=0.113          (e)              P=0.270                                                            |
|COCH-ARM / FISHERS |        P=0.097          (e)              P=0.254                                                            |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/98 (4%)        6/99 (6%)        4/100 (4%)                                                         |
|POLY-3 ADJUSTED (b)|        4.2%             6.3%             4.1%                                                               |
|TERMINAL (d)       |        1/88 (1%)        1/85 (1%)        0/91 (0%)                                                          |
|FIRST INCIDENCE    |        135              115              106                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.484N         P=0.361          P=0.632N                                                           |
|POLY 3             |        P=0.482N         P=0.378          P=0.625N                                                           |
|POLY 1.5           |        P=0.485N         P=0.379          P=0.627N                                                           |
|POLY 6             |        P=0.480N         P=0.373          P=0.625N                                                           |
|LOGISTIC REGRESSION|        P=0.485N         P=0.421          P=0.617N                                                           |
|COCH-ARM / FISHERS |        P=0.488N         P=0.380          P=0.628N                                                           |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/98 (1%)        3/100 (3%)       1/100 (1%)                                                         |
|POLY-3 ADJUSTED (b)|        1.1%             3.2%             1.0%                                                               |
|TERMINAL (d)       |        0/88 (0%)        1/85 (1%)        1/91 (1%)                                                          |
|FIRST INCIDENCE    |        135              131              183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.487N         P=0.298          P=0.755N                                                           |
|POLY 3             |        P=0.497N         P=0.304          P=0.758N                                                           |
|POLY 1.5           |        P=0.496N         P=0.308          P=0.757N                                                           |
|POLY 6             |        P=0.497N         P=0.300          P=0.758N                                                           |
|LOGISTIC REGRESSION|        P=0.474N         P=0.364          P=0.740N                                                           |
|COCH-ARM / FISHERS |        P=0.494N         P=0.318          P=0.746N                                                           |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        21/98 (21%)      10/100 (10%)     14/100 (14%)                                                       |
|POLY-3 ADJUSTED (b)|        22.4%            10.8%            14.7%                                                              |
|TERMINAL (d)       |        21/88 (24%)      10/85 (12%)      14/91 (15%)                                                        |
|FIRST INCIDENCE    |        183 (T)          183 (T)          183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.226N         P=0.031N*        P=0.108N                                                           |
|POLY 3             |        P=0.244N         P=0.026N*        P=0.119N                                                           |
|POLY 1.5           |        P=0.251N         P=0.024N*        P=0.119N                                                           |
|POLY 6             |        P=0.236N         P=0.029N*        P=0.118N                                                           |
|LOGISTIC REGRESSION|        P=0.226N         P=0.031N*        P=0.108N                                                           |
|COCH-ARM / FISHERS |        P=0.260N         P=0.021N*        P=0.118N                                                           |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        21/98 (21%)      18/100 (18%)     14/100 (14%)                                                       |
|POLY-3 ADJUSTED (b)|        21.9%            19.3%            14.6%                                                              |
|TERMINAL (d)       |        17/88 (19%)      17/85 (20%)      13/91 (14%)                                                        |
|FIRST INCIDENCE    |        89               91               135                                                                |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.106N         P=0.404N         P=0.118N                                                           |
|POLY 3             |        P=0.123N         P=0.396N         P=0.131N                                                           |
|POLY 1.5           |        P=0.124N         P=0.372N         P=0.128N                                                           |
|POLY 6             |        P=0.119N         P=0.422N         P=0.133N                                                           |
|LOGISTIC REGRESSION|        P=0.121N         P=0.303N         P=0.112N                                                           |
|COCH-ARM / FISHERS |        P=0.121N         P=0.334N         P=0.118N                                                           |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/100 (0%)       2/100 (2%)       1/100 (1%)                                                         |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             1.0%                                                               |
|TERMINAL (d)       |        0/88 (0%)        1/85 (1%)        1/91 (1%)                                                          |
|FIRST INCIDENCE    |        ---              166              183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.616          P=0.231          P=0.507                                                            |
|POLY 3             |        P=0.608          P=0.235          P=0.502                                                            |
|POLY 1.5           |        P=0.607          P=0.236          P=0.501                                                            |
|POLY 6             |        P=0.610          P=0.233          P=0.503                                                            |
|LOGISTIC REGRESSION|        P=0.605          P=0.241          P=0.507                                                            |
|COCH-ARM / FISHERS |        P=0.606          P=0.249          P=0.500                                                            |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 11                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 26 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/19 (32%)       0/8 (0%)         3/13 (23%)                                                         |
|POLY-3 ADJUSTED (b)|        31.6%            0.0%             23.1%                                                              |
|TERMINAL (d)       |        6/19 (32%)       0/8 (0%)         3/13 (23%)                                                         |
|FIRST INCIDENCE    |        183 (T)          ---              183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.538N         P=0.102N         P=0.451N                                                           |
|POLY 3             |        P=0.539N         P=0.092N         P=0.452N                                                           |
|POLY 1.5           |        P=0.539N         P=0.092N         P=0.452N                                                           |
|POLY 6             |        P=0.539N         P=0.092N         P=0.452N                                                           |
|LOGISTIC REGRESSION|        P=0.538N         (e)              P=0.451N                                                           |
|COCH-ARM / FISHERS |        P=0.539N         P=0.092N         P=0.455N                                                           |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                    Females                                                  |
|Dose               |        10 DMBA          50 HZ/1G         50 HZ/5G                                                           |
|                   |        CONTROL           10 DMBA          10 DMBA                                                           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperplasia Basal Cell                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/19 (32%)       1/8 (13%)        1/13 (8%)                                                          |
|POLY-3 ADJUSTED (b)|        31.6%            12.5%            7.7%                                                               |
|TERMINAL (d)       |        6/19 (32%)       1/8 (13%)        1/13 (8%)                                                          |
|FIRST INCIDENCE    |        183 (T)          183 (T)          183 (T)                                                            |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.125N         P=0.294N         P=0.125N                                                           |
|POLY 3             |        P=0.121N         P=0.294N         P=0.119N                                                           |
|POLY 1.5           |        P=0.121N         P=0.294N         P=0.119N                                                           |
|POLY 6             |        P=0.121N         P=0.294N         P=0.119N                                                           |
|LOGISTIC REGRESSION|        P=0.125N         P=0.294N         P=0.125N                                                           |
|COCH-ARM / FISHERS |        P=0.122N         P=0.301N         P=0.120N                                                           |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).