TDMS Study 89029-11 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 01/27/98
EXPERIMENT: 89029 TEST: 11 TIME: 10:39:05
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D
PATHOLOGIST: GRUMBEIN, SONDRA CAS: EMF+DMBA
------------------------------------------------------------------------------------------------------------------------------------
10(10MGX1)DMBA V 50HZ/1G 10(10MGX1)DMBA V 50HZ/5G 10(10MGX1)DMBA V 60HZ/1G 10(10MGX1)DMBA
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: MERGE 001 001 10 DMBA CONTROL
MERGE 002 003 50 HZ/1G 10 DMBA
MERGE 003 005 50 HZ/5G 10 DMBA
MERGE 004 004 60 HZ/1G 10 DMBA
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 01/27/98
EXPERIMENT: 89029 TEST: 11 TIME: 10:39:05
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D
PATHOLOGIST: GRUMBEIN, SONDRA CAS: EMF+DMBA
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 DMBA CONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 88 |
| |
| UNCENSORED DEATHS |
| 89 110 113 113 135 145 151 162 173 176 |
| 176 182 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 HZ/1G 10 DMBA |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 85 |
| |
| UNCENSORED DEATHS |
| 91 114 115 115 127 131 132 134 157 160 |
| 162 164 166 172 182 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 HZ/5G 10 DMBA |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 91 |
| |
| UNCENSORED DEATHS |
| 77 89 106 135 138 162 165 173 176 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 60 HZ/1G 10 DMBA |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 94 |
| |
| UNCENSORED DEATHS |
| 71 85 151 162 162 174 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 183 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 183 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|10 | 99.0 89.0 88.0 88.0 88.0 88.0 88.0 88.0 88.0 88.0 |
|DMBA CONTRO| |
| | |
|50 | 100.0 86.0 85.0 85.0 85.0 85.0 85.0 85.0 85.0 85.0 |
|HZ/1G 10 DM|A |
| | |
|50 | 98.0 91.0 91.0 91.0 91.0 91.0 91.0 91.0 91.0 91.0 |
|HZ/5G 10 DM|A |
| | |
|60 | 98.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 |
|HZ/1G 10 DM|A |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 10 50 50 60 |
| DMBA CONTROL HZ/1G 10 DMBAHZ/5G 10 DMBAHZ/1G 10 |MBA
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.0% 85.0% 91.0% 94.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 143.8 141.5 135.7 134.2 |
|NATURAL DEATHS (C) | ( 9.1) ( 6.9) (12.4) (18.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 178.3 176.8 178.7 180.1 |
|(STANDARD ERROR) | ( 1.7) ( 1.8) ( 1.7) ( 1.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
KAPLAN-MEIER SURVIVAL CURVES
10 DMBA CONTROL = 1
50 HZ/1G 10 DMBA = 2
50 HZ/5G 10 DMBA = 3
60 HZ/1G 10 DMBA = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1
|
| 3 1 1 2
|
98 + 3 1 1 4
|
| 3 3 4 4
|
P 96 + 1 2 1
E |
R | 1 1 3 4
C |
E 94 + 1 1 4 4
N |
T | 2 2 1 1 3
|
S 92 + 2 2 1 1 3
U |
R | 1 1 3
V |
I 90 + 2 2
V |
A |
L |
88 + 1 1
|
| 2 2
|
86 + 2 2
|
| 2 2
|
84 +
|
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
WEEK
NOTE: 17 obs hidden.