National Toxicology Program

National Toxicology Program
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TDMS Study 89029-12 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                        MAGNETIC FIELDS + DMBA INITIATION PROMOTION                     DATE: 01/07/98

EXPERIMENT: 89029 TEST: 12                                                                                     TIME: 16:02:40
TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-65397                              ROUTE: MAGNETIC FIELDS                                         NTP C#: 89029D
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: EMF+DMBA
                    

Rats(SPRAGUE-DAWLEY)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                        MAGNETIC FIELDS + DMBA INITIATION PROMOTION                     DATE: 01/07/98     
EXPERIMENT: 89029 TEST: 12                                                                                     TIME: 16:02:40     
TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-65397                              ROUTE: MAGNETIC FIELDS                                         NTP C#: 89029D     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: EMF+DMBA      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF    MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
===============================================================

Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Mammary Gland                          Carcinoma
                                       Carcinoma or Adenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 12                                            Page 1

Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)        -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 12 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/100 (2%)       0/100 (0%)       1/100 (1%)       1/100 (1%)       0/100 (0%)                       |
|POLY-3 ADJUSTED (b)|        2.1%             0.0%             1.1%             1.0%             0.0%                             |
|TERMINAL (d)       |        2/94 (2%)        0/100 (0%)       1/87 (1%)        1/95 (1%)        0/92 (0%)                        |
|FIRST INCIDENCE    |        90 (T)           ---              90 (T)           90 (T)           ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.195N         P=0.226N         P=0.527N         P=0.496N         P=0.244N                         |
|POLY 3             |        P=0.195N         P=0.233N         P=0.509N         P=0.497N         P=0.240N                         |
|POLY 1.5           |        P=0.192N         P=0.235N         P=0.505N         P=0.498N         P=0.240N                         |
|POLY 6             |        P=0.199N         P=0.230N         P=0.514N         P=0.495N         P=0.242N                         |
|LOGISTIC REGRESSION|        P=0.195N         (e)              P=0.527N         P=0.496N         (e)                              |
|COCH-ARM / FISHERS |        P=0.187N         P=0.249N         P=0.500N         P=0.500N         P=0.249N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        92/100 (92%)     0/100 (0%)       86/100 (86%)     96/100 (96%)     96/100 (96%)                     |
|POLY-3 ADJUSTED (b)|        92.7%            0.0%             88.6%            96.0%            96.7%                            |
|TERMINAL (d)       |        87/94 (93%)      0/100 (0%)       79/87 (91%)      91/95 (96%)      89/92 (97%)                      |
|FIRST INCIDENCE    |        72               ---              73               64               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001N**       P=0.534          P=0.328          P=0.144                          |
|POLY 3             |        P<0.001 **       P<0.001N**       P=0.222N         P=0.238          P=0.168                          |
|POLY 1.5           |        P<0.001 **       P<0.001N**       P=0.177N         P=0.218          P=0.173                          |
|POLY 6             |        P<0.001 **       P<0.001N**       P=0.290N         P=0.256          P=0.166                          |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001N**       P=0.201N         P=0.206          P=0.161                          |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001N**       P=0.129N         P=0.186          P=0.186                          |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 12                                            Page 2

Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 12 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        93/100 (93%)     0/100 (0%)       86/100 (86%)     96/100 (96%)     96/100 (96%)                     |
|POLY-3 ADJUSTED (b)|        93.7%            0.0%             88.6%            96.0%            96.7%                            |
|TERMINAL (d)       |        88/94 (94%)      0/100 (0%)       79/87 (91%)      91/95 (96%)      89/92 (97%)                      |
|FIRST INCIDENCE    |        72               ---              73               64               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001N**       P=0.548N         P=0.410          P=0.193                          |
|POLY 3             |        P<0.001 **       P<0.001N**       P=0.148N         P=0.337          P=0.251                          |
|POLY 1.5           |        P<0.001 **       P<0.001N**       P=0.114N         P=0.311          P=0.255                          |
|POLY 6             |        P<0.001 **       P<0.001N**       P=0.202N         P=0.359          P=0.249                          |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001N**       P=0.134N         P=0.295          P=0.238                          |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001N**       P=0.083N         P=0.269          P=0.269                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/100 (3%)       0/100 (0%)       2/100 (2%)       1/100 (1%)       1/100 (1%)                       |
|POLY-3 ADJUSTED (b)|        3.1%             0.0%             2.1%             1.0%             1.0%                             |
|TERMINAL (d)       |        3/94 (3%)        0/100 (0%)       2/87 (2%)        1/95 (1%)        1/92 (1%)                        |
|FIRST INCIDENCE    |        90 (T)           ---              90 (T)           90 (T)           90 (T)                           |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.263N         P=0.112N         P=0.535N         P=0.303N         P=0.315N                         |
|POLY 3             |        P=0.260N         P=0.117N         P=0.512N         P=0.304N         P=0.310N                         |
|POLY 1.5           |        P=0.256N         P=0.119N         P=0.507N         P=0.305N         P=0.309N                         |
|POLY 6             |        P=0.264N         P=0.115N         P=0.518N         P=0.302N         P=0.312N                         |
|LOGISTIC REGRESSION|        P=0.263N         (e)              P=0.535N         P=0.303N         P=0.315N                         |
|COCH-ARM / FISHERS |        P=0.251N         P=0.123N         P=0.500N         P=0.311N         P=0.311N                         |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 12                                            Page 3

Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 12 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/100 (5%)       0/100 (0%)       3/100 (3%)       2/100 (2%)       1/100 (1%)                       |
|POLY-3 ADJUSTED (b)|        5.1%             0.0%             3.2%             2.0%             1.0%                             |
|TERMINAL (d)       |        5/94 (5%)        0/100 (0%)       3/87 (3%)        2/95 (2%)        1/92 (1%)                        |
|FIRST INCIDENCE    |        90 (T)           ---              90 (T)           90 (T)           90 (T)                           |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.128N         P=0.030N*        P=0.402N         P=0.217N         P=0.112N                         |
|POLY 3             |        P=0.125N         P=0.032N*        P=0.373N         P=0.217N         P=0.108N                         |
|POLY 1.5           |        P=0.122N         P=0.033N*        P=0.368N         P=0.219N         P=0.107N                         |
|POLY 6             |        P=0.129N         P=0.031N*        P=0.382N         P=0.216N         P=0.109N                         |
|LOGISTIC REGRESSION|        P=0.128N         (e)              P=0.402N         P=0.217N         P=0.112N                         |
|COCH-ARM / FISHERS |        P=0.118N         P=0.030N*        P=0.360N         P=0.222N         P=0.106N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        93/100 (93%)     0/100 (0%)       86/100 (86%)     96/100 (96%)     96/100 (96%)                     |
|POLY-3 ADJUSTED (b)|        93.7%            0.0%             88.6%            96.0%            96.7%                            |
|TERMINAL (d)       |        88/94 (94%)      0/100 (0%)       79/87 (91%)      91/95 (96%)      89/92 (97%)                      |
|FIRST INCIDENCE    |        72               ---              73               64               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001N**       P=0.548N         P=0.410          P=0.193                          |
|POLY 3             |        P<0.001 **       P<0.001N**       P=0.148N         P=0.337          P=0.251                          |
|POLY 1.5           |        P<0.001 **       P<0.001N**       P=0.114N         P=0.311          P=0.255                          |
|POLY 6             |        P<0.001 **       P<0.001N**       P=0.202N         P=0.359          P=0.249                          |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001N**       P=0.134N         P=0.295          P=0.238                          |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001N**       P=0.083N         P=0.269          P=0.269                          |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 12                                            Page 4

Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 12 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        15/100 (15%)     0/100 (0%)       16/100 (16%)     12/100 (12%)     10/100 (10%)                     |
|POLY-3 ADJUSTED (b)|        15.1%            0.0%             16.1%            12.2%            10.1%                            |
|TERMINAL (d)       |        11/94 (12%)      0/100 (0%)       6/87 (7%)        11/95 (12%)      5/92 (5%)                        |
|FIRST INCIDENCE    |        58               ---              49               89               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.411          P<0.001N**       P=0.442          P=0.333N         P=0.216N                         |
|POLY 3             |        P=0.422          P<0.001N**       P=0.497          P=0.352N         P=0.202N                         |
|POLY 1.5           |        P=0.428          P<0.001N**       P=0.499          P=0.347N         P=0.200N                         |
|POLY 6             |        P=0.414          P<0.001N**       P=0.493          P=0.358N         P=0.205N                         |
|LOGISTIC REGRESSION|        P=0.465N         P<0.001N**       P=0.373N         P=0.393N         P=0.133N                         |
|COCH-ARM / FISHERS |        P=0.439          P<0.001N**       P=0.500          P=0.340N         P=0.196N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/100 (5%)       0/100 (0%)       3/100 (3%)       2/100 (2%)       1/100 (1%)                       |
|POLY-3 ADJUSTED (b)|        5.1%             0.0%             3.2%             2.0%             1.0%                             |
|TERMINAL (d)       |        5/94 (5%)        0/100 (0%)       3/87 (3%)        2/95 (2%)        1/92 (1%)                        |
|FIRST INCIDENCE    |        90 (T)           ---              90 (T)           90 (T)           90 (T)                           |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.128N         P=0.030N*        P=0.402N         P=0.217N         P=0.112N                         |
|POLY 3             |        P=0.125N         P=0.032N*        P=0.373N         P=0.217N         P=0.108N                         |
|POLY 1.5           |        P=0.122N         P=0.033N*        P=0.368N         P=0.219N         P=0.107N                         |
|POLY 6             |        P=0.129N         P=0.031N*        P=0.382N         P=0.216N         P=0.109N                         |
|LOGISTIC REGRESSION|        P=0.128N         (e)              P=0.402N         P=0.217N         P=0.112N                         |
|COCH-ARM / FISHERS |        P=0.118N         P=0.030N*        P=0.360N         P=0.222N         P=0.106N                         |
|=================================================================================================================================|
       Date:  01/07/98                           EXPERIMENT: 89029 TEST: 12                                            Page 5

Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     MAGNETIC FIELDS + DMBA INITIATION PROMOTIO
                                         Terminal Sacrifice at 12 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        93/100 (93%)     0/100 (0%)       92/100 (92%)     96/100 (96%)     96/100 (96%)                     |
|POLY-3 ADJUSTED (b)|        93.0%            0.0%             92.0%            96.0%            96.7%                            |
|TERMINAL (d)       |        87/94 (93%)      0/100 (0%)       79/87 (91%)      91/95 (96%)      89/92 (97%)                      |
|FIRST INCIDENCE    |        58               ---              49               64               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001N**       P=0.208          P=0.413          P=0.204                          |
|POLY 3             |        P<0.001 **       P<0.001N**       P=0.500N         P=0.268          P=0.193                          |
|POLY 1.5           |        P<0.001 **       P<0.001N**       P=0.500N         P=0.268          P=0.217                          |
|POLY 6             |        P<0.001 **       P<0.001N**       P=0.500N         P=0.268          P=0.176                          |
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.257                          |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001N**       P=0.500N         P=0.269          P=0.269                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        20 DMBA          UNTREATD         50 HZ/1G         60 HZ/1G         50 HZ/5G                         |
|                   |        CONTROL          CONTROL           20 DMBA          20 DMBA          20 DMBA                         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        94/100 (94%)     0/100 (0%)       92/100 (92%)     96/100 (96%)     96/100 (96%)                     |
|POLY-3 ADJUSTED (b)|        94.0%            0.0%             92.0%            96.0%            96.7%                            |
|TERMINAL (d)       |        88/94 (94%)      0/100 (0%)       79/87 (91%)      91/95 (96%)      89/92 (97%)                      |
|FIRST INCIDENCE    |        58               ---              49               64               65                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001N**       P=0.257          P=0.499          P=0.264                          |
|POLY 3             |        P<0.001 **       P<0.001N**       P=0.391N         P=0.373          P=0.284                          |
|POLY 1.5           |        P<0.001 **       P<0.001N**       P=0.391N         P=0.373          P=0.314                          |
|POLY 6             |        P<0.001 **       P<0.001N**       P=0.391N         P=0.373          P=0.261                          |
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.360                          |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001N**       P=0.391N         P=0.374          P=0.374                          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.