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TDMS Study 89029-12 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                        MAGNETIC FIELDS + DMBA INITIATION PROMOTION                     DATE: 01/27/98       
EXPERIMENT: 89029 TEST: 12                                                                                     TIME: 23:53:24       
TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-65397                              ROUTE: MAGNETIC FIELDS                                         NTP C#: 89029D       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: EMF+DMBA        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                   20MG(5MGX4)DMBA V 50 HZ/1G 20MG(5MGX4)DMBA V 50 HZ/5G 20MG(5MGX4)DMBA V 60 HZ/1G 20MG(5MGX4)DMBA                                                                                                                                
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       MERGE   001   001                        20 DMBA CONTROL                                     
                                       MERGE   002   003                        50 HZ/1G 20 DMBA                                    
                                       MERGE   003   005                        50 HZ/5G 20 DMBA                                    
                                       MERGE   004   004                        60 HZ/1G 20 DMBA                                    
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                        MAGNETIC FIELDS + DMBA INITIATION PROMOTION                     DATE: 01/27/98      
EXPERIMENT: 89029 TEST: 12                                                                                     TIME: 23:53:24      
TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-65397                              ROUTE: MAGNETIC FIELDS                                         NTP C#: 89029D      
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: EMF+DMBA       
                    MAGNETIC FIELDS + DMBA INITIATION PROMOTION

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 90 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 20 DMBA CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 94        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      58    72    72    73    75    89                                          |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 50 HZ/1G 20 DMBA                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 87        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      49    66    66    72    73    75    81    81    81    82                  |
 |      82    84    84                                                            |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 50 HZ/5G 20 DMBA                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 8      CENSORED DEATHS 0    TERMINAL 92        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      59    65    70    77    77    79    79    84                              |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                    MAGNETIC FIELDS + DMBA INITIATION PROMOTION

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 90 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 60 HZ/1G 20 DMBA                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 95        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      64    70    80    84    89                                                |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                    MAGNETIC FIELDS + DMBA INITIATION PROMOTION

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 90 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665    90 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |20         |    94.0  94.0  94.0  94.0  94.0  94.0  94.0  94.0  94.0  94.0      |
 |DMBA CONTRO|                                                                    |
 |           |                                                                    |
 |50         |    87.0  87.0  87.0  87.0  87.0  87.0  87.0  87.0  87.0  87.0      |
 |HZ/1G 20 DM|A                                                                   |
 |           |                                                                    |
 |50         |    92.0  92.0  92.0  92.0  92.0  92.0  92.0  92.0  92.0  92.0      |
 |HZ/5G 20 DM|A                                                                   |
 |           |                                                                    |
 |60         |    95.0  95.0  95.0  95.0  95.0  95.0  95.0  95.0  95.0  95.0      |
 |HZ/1G 20 DM|A                                                                   |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                20           50           50           60       |
 |                                DMBA CONTROL HZ/1G 20 DMBAHZ/5G 20 DMBAHZ/1G 20 |MBA
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       94.0%        87.0%        92.0%        95.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----        -----        -----        -----   |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |        73.2         75.1         73.8         77.4    |
 |NATURAL DEATHS (C)      |       ( 4.0)       ( 2.8)       ( 3.0)       ( 4.6)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |        89.0         88.1         88.7         89.4    |
 |(STANDARD ERROR)        |       ( 0.5)       ( 0.6)       ( 0.5)       ( 0.3)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                            MAGNETIC FIELDS + DMBA INITIATION PROMOTION
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        20 DMBA CONTROL  = 1
                                                        50 HZ/1G 20 DMBA = 2
                                                        50 HZ/5G 20 DMBA = 3
                                                        60 HZ/1G 20 DMBA = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

       |
       |
   100 +  1                                                              2                 1        4
       |
       |                                                                 2                 1        2        1
       |
    98 +                                                                                            4                 4
       |
 P     |                                                                                            2        2
 E     |
 R  96 +                                                                                                              4        4
 C     |
 E     |                                                                                                     1        3        1
 N     |
 T  94 +                                                                                                     2        2        1
       |
 S     |
 U     |
 R  92 +                                                                                                              3        3
 V     |
 I     |
 V     |
 A  90 +
 L     |
       |
       |
    88 +
       |
       |                                                                                                              2        2
       |
    86 +
       |
       ---+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--
          0        1        2        3        4        5        6        7        8        9       10       11       12       13

                                                                   WEEK

NOTE: 10 obs hidden.