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TDMS Study 90004-06 Pathology Tables

                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/04/02       
EXPERIMENT: 90004 TEST: 06                                                                                     TIME: 15:15:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: MISSING                                                                                           CAS: 57018-52-7      
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/04/02       
EXPERIMENT: 90004 TEST: 06                                                                                     TIME: 15:15:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: MISSING                                                                                           CAS: 57018-52-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF           PROPYLENE GLYCOL MONO-T-BUTYL ET                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatoblastoma                                                                               
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
All Organs                             Benign Tumors                                                                                
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatoblastoma                                                                               
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                  
                                       Sarcoma                                                                                      
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
                                       Benign Tumors                                                                                
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -            PROPYLENE GLYCOL MONO-T-BUTYL ET    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/49 (2%)    1/50 (2%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/44.56      1/44.95      1/45.18      4/44.78     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         2.2%         8.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    1/40 (3%)    3/37 (8%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      711         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      P=0.732N     P=0.732N     P=0.195     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.057      P=0.759N     P=0.758N     P=0.180     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.059      P=0.760N     P=0.755N     P=0.185     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.054      P=0.756N     P=0.759N     P=0.175     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.050      P=0.732N     P=0.732N     P=0.175     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.061      P=0.747N     P=0.742N     P=0.194     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      2/44.95      0/45.18      0/44.71     |1/47.12      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |624          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.392N     P=0.268      (e)          (e)         |P=0.558N     P=0.513N     P=0.500N     P=0.517N     | 
|POLY 3             |     P=0.389N     P=0.239      (e)          (e)         |P=0.548N     P=0.503N     P=0.496N     P=0.509N     | 
|POLY 1.5           |     P=0.389N     P=0.238      (e)          (e)         |P=0.550N     P=0.500N     P=0.496N     P=0.507N     | 
|POLY 6             |     P=0.389N     P=0.242      (e)          (e)         |P=0.546N     P=0.507N     P=0.496N     P=0.510N     | 
|LOGISTIC REGRESSION|     (e)          P=0.268      (e)          (e)         |P=0.406N     P=0.340N     P=0.574N     P=0.374N     | 
|COCH-ARM / FISHERS |     P=0.384N     P=0.253      (e)          (e)         |P=0.553N     P=0.495N     P=0.495N     P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    4/50 (8%)   |3/50 (6%)    4/50 (8%)    5/50 (10%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     6/46.18      4/45.45      4/45.18      4/45.06     |3/47.55      4/46.71      5/48.81      4/45.40      | 
|POLY-3 PERCENT (g) |     13.0%        8.8%         8.9%         8.9%        |6.3%         8.6%         10.2%        8.8%         | 
|TERMINAL (d)       |     5/35 (14%)   3/40 (8%)    4/40 (10%)   3/37 (8%)   |3/39 (8%)    2/36 (6%)    2/42 (5%)    4/39 (10%)   | 
|FIRST INCIDENCE    |     671          663          729 (T)      632         |731 (T)      643          600          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.445N     P=0.307N     P=0.297N     P=0.348N    |P=0.537      P=0.462      P=0.393      P=0.500      | 
|POLY 3             |     P=0.440N     P=0.379N     P=0.383N     P=0.385N    |P=0.503      P=0.490      P=0.371      P=0.475      | 
|POLY 1.5           |     P=0.433N     P=0.384N     P=0.378N     P=0.379N    |P=0.507      P=0.494      P=0.365      P=0.479      | 
|POLY 6             |     P=0.449N     P=0.368N     P=0.384N     P=0.388N    |P=0.504      P=0.486      P=0.382      P=0.475      | 
|LOGISTIC REGRESSION|     P=0.447N     P=0.377N     P=0.369N     P=0.385N    |P=0.526      P=0.490      P=0.331      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.431N     P=0.370N     P=0.370N     P=0.370N    |P=0.519      P=0.500      P=0.357      P=0.489      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/45.96      1/45.21      0/45.18      2/44.78     |0/47.55      2/46.83      0/48.03      2/45.40      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         4.5%        |0.0%         4.3%         0.0%         4.4%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    0/40 (0%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          711         |---          630          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.310      P=0.732N     P=0.473N     P=0.513     |P=0.290      P=0.230      (e)          P=0.238      | 
|POLY 3             |     P=0.313      P=0.757      P=0.503N     P=0.491     |P=0.275      P=0.234      (e)          P=0.227      | 
|POLY 1.5           |     P=0.316      P=0.756      P=0.502N     P=0.494     |P=0.277      P=0.235      (e)          P=0.229      | 
|POLY 6             |     P=0.310      P=0.761N     P=0.503N     P=0.489     |P=0.274      P=0.233      (e)          P=0.227      | 
|LOGISTIC REGRESSION|     P=0.304      P=0.732N     (e)          P=0.490     |P=0.308      P=0.299      (e)          P=0.238      | 
|COCH-ARM / FISHERS |     P=0.317      P=0.753N     P=0.500N     P=0.500     |P=0.283      P=0.247      (e)          P=0.242      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   4/50 (8%)    6/50 (12%)  |3/50 (6%)    6/50 (12%)   5/50 (10%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     7/46.18      5/45.45      4/45.18      6/45.13     |3/47.55      6/47.17      5/48.81      5/45.40      | 
|POLY-3 PERCENT (g) |     15.2%        11.0%        8.9%         13.3%       |6.3%         12.7%        10.2%        11.0%        | 
|TERMINAL (d)       |     6/35 (17%)   4/40 (10%)   4/40 (10%)   4/37 (11%)  |3/39 (8%)    2/36 (6%)    2/42 (5%)    5/39 (13%)   | 
|FIRST INCIDENCE    |     671          663          729 (T)      632         |731 (T)      630          600          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.548      P=0.306N     P=0.196N     P=0.472N    |P=0.500      P=0.219      P=0.393      P=0.355      | 
|POLY 3             |     P=0.554      P=0.390N     P=0.273N     P=0.518N    |P=0.460      P=0.238      P=0.371      P=0.332      | 
|POLY 1.5           |     P=0.561      P=0.395N     P=0.269N     P=0.511N    |P=0.466      P=0.240      P=0.365      P=0.336      | 
|POLY 6             |     P=0.545      P=0.378N     P=0.274N     P=0.521N    |P=0.459      P=0.238      P=0.382      P=0.331      | 
|LOGISTIC REGRESSION|     P=0.542      P=0.385N     P=0.257N     P=0.523N    |P=0.503      P=0.260      P=0.331      P=0.355      | 
|COCH-ARM / FISHERS |     P=0.563      P=0.380N     P=0.262N     P=0.500N    |P=0.481      P=0.243      P=0.357      P=0.346      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      2/45.21      1/45.18      0/44.71     |0/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    1/40 (3%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.369N     P=0.268      P=0.527      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.374N     P=0.234      P=0.497      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.372N     P=0.232      P=0.498      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.375N     P=0.237      P=0.497      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.527      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.247      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/46.03      1/45.21      1/45.18      1/44.71     |0/47.55      0/46.36      0/48.03      1/45.40      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         2.2%         2.2%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    1/40 (3%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     711          729 (T)      729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529N     P=0.460N     P=0.463N     P=0.487N    |P=0.230      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.526N     P=0.506N     P=0.507N     P=0.510N    |P=0.222      (e)          (e)          P=0.491      | 
|POLY 1.5           |     P=0.522N     P=0.508N     P=0.504N     P=0.506N    |P=0.223      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.531N     P=0.501N     P=0.506N     P=0.513N    |P=0.223      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.536N     P=0.495N     P=0.500N     P=0.510N    |(e)          (e)          (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.521N     P=0.500N     P=0.500N     P=0.500N    |P=0.224      (e)          (e)          P=0.495      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/46.03      1/45.21      2/45.18      1/44.71     |1/47.74      0/46.36      0/48.03      1/45.40      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         4.4%         2.2%        |2.1%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    2/40 (5%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     711          729 (T)      729 (T)      729 (T)     |680          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.495N     P=0.460N     P=0.652N     P=0.487N    |P=0.520      P=0.513N     P=0.509N     P=0.753      | 
|POLY 3             |     P=0.494N     P=0.506N     P=0.687      P=0.510N    |P=0.516      P=0.506N     P=0.499N     P=0.749      | 
|POLY 1.5           |     P=0.489N     P=0.508N     P=0.690      P=0.506N    |P=0.516      P=0.503N     P=0.499N     P=0.751      | 
|POLY 6             |     P=0.501N     P=0.501N     P=0.688      P=0.513N    |P=0.518      P=0.509N     P=0.498N     P=0.749      | 
|LOGISTIC REGRESSION|     P=0.503N     P=0.495N     P=0.693N     P=0.510N    |P=0.528      P=0.455N     P=0.523N     P=0.762N     | 
|COCH-ARM / FISHERS |     P=0.487N     P=0.500N     P=0.691N     P=0.500N    |P=0.517      P=0.500N     P=0.500N     P=0.747      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/45.96      2/45.21      2/45.18      1/44.71     |0/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         4.4%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    2/40 (5%)    2/40 (5%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.519N     P=0.547      P=0.547      P=0.749N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.522N     P=0.494      P=0.494      P=0.755     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.517N     P=0.492      P=0.496      P=0.757     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.527N     P=0.500      P=0.495      P=0.753     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.519N     P=0.547      P=0.547      P=0.749N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.513N     P=0.500      P=0.500      P=0.753N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/44.56      0/44.95      0/45.18      0/44.71     |1/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.209N     P=0.209N     P=0.226N    |P=0.543N     P=0.516N     P=0.485N     P=0.500N     | 
|POLY 3             |     P=0.300N     P=0.235N     P=0.234N     P=0.236N    |P=0.550N     P=0.502N     P=0.495N     P=0.507N     | 
|POLY 1.5           |     P=0.299N     P=0.237N     P=0.232N     P=0.233N    |P=0.551N     P=0.499N     P=0.495N     P=0.507N     | 
|POLY 6             |     P=0.304N     P=0.232N     P=0.235N     P=0.240N    |P=0.548N     P=0.505N     P=0.494N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.309N     (e)          (e)          (e)         |P=0.543N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.303N     P=0.242N     P=0.237N     P=0.237N    |P=0.553N     P=0.495N     P=0.495N     P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/45.96      0/44.95      0/45.18      0/44.71     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.209N     P=0.209N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.306N     P=0.242N     P=0.241N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.304N     P=0.245N     P=0.240N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.311N     P=0.237N     P=0.240N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.309N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.307N     P=0.253N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    1/50 (2%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/46.27      0/44.95      1/45.60      1/44.78     |0/46.74      2/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         2.2%         2.2%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    2/36 (6%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     668          ---          606          711         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.671N     P=0.239N     P=0.518N     P=0.514N    |P=0.385N     P=0.221      (e)          (e)          | 
|POLY 3             |     P=0.656N     P=0.244N     P=0.505N     P=0.511N    |P=0.401N     P=0.235      (e)          (e)          | 
|POLY 1.5           |     P=0.651N     P=0.246N     P=0.503N     P=0.507N    |P=0.398N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.663N     P=0.240N     P=0.504N     P=0.515N    |P=0.405N     P=0.232      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.653N     P=0.238N     P=0.497N     P=0.498N    |(e)          P=0.221      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.651N     P=0.253N     P=0.500N     P=0.500N    |P=0.392N     P=0.253      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    5/50 (10%)  |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      1/45.18      5/44.71     |0/46.74      0/46.36      0/48.03      2/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         11.2%       |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/40 (3%)    5/37 (14%)  |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.527      P=0.038 *   |P=0.043 *    (e)          (e)          P=0.238      | 
|POLY 3             |     P<0.001 **   (e)          P=0.497      P=0.028 *   |P=0.039 *    (e)          (e)          P=0.231      | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.498      P=0.029 *   |P=0.039 *    (e)          (e)          P=0.233      | 
|POLY 6             |     P<0.001 **   (e)          P=0.497      P=0.027 *   |P=0.039 *    (e)          (e)          P=0.230      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.527      P=0.038 *   |(e)          (e)          (e)          P=0.238      | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.500      P=0.028 *   |P=0.041 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  23/49 (47%)  26/50 (52%)  36/50 (72%) |14/49 (29%)  8/50 (16%)   10/50 (20%)  37/49 (76%)  | 
|POLY-3 RATE (b)    |     18/46.93     23/45.11     26/45.60     36/46.93    |14/46.96     8/46.80      10/48.03     37/46.66     | 
|POLY-3 PERCENT (g) |     38.4%        51.0%        57.0%        76.7%       |29.8%        17.1%        20.8%        79.3%        | 
|TERMINAL (d)       |     13/35 (37%)  21/40 (53%)  24/40 (60%)  29/37 (78%) |12/39 (31%)  7/36 (19%)   10/42 (24%)  32/39 (82%)  | 
|FIRST INCIDENCE    |     622          705          642          527         |680          602          731 (T)      519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.376      P=0.187      P=0.002 **  |P<0.001 **   P=0.158N     P=0.185N     P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.154      P=0.052      P<0.001 **  |P<0.001 **   P=0.112N     P=0.220N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.154      P=0.062      P<0.001 **  |P<0.001 **   P=0.108N     P=0.222N     P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.159      P=0.045 *    P<0.001 **  |P<0.001 **   P=0.118N     P=0.218N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.196      P=0.059      P<0.001 **  |P<0.001 **   P=0.123N     P=0.200N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.184      P=0.079      P<0.001 **  |P<0.001 **   P=0.103N     P=0.224N     P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   8/49 (16%)   13/50 (26%)  11/50 (22%) |4/49 (8%)    8/50 (16%)   7/50 (14%)   10/49 (20%)  | 
|POLY-3 RATE (b)    |     9/46.90      8/45.11      13/48.04     11/46.52    |4/47.39      8/47.98      7/48.48      10/47.16     | 
|POLY-3 PERCENT (g) |     19.2%        17.7%        27.1%        23.7%       |8.4%         16.7%        14.4%        21.2%        | 
|TERMINAL (d)       |     5/35 (14%)   6/40 (15%)   7/40 (18%)   5/37 (14%)  |1/39 (3%)    3/36 (8%)    6/42 (14%)   6/39 (15%)   | 
|FIRST INCIDENCE    |     630          705          463          560         |624          586          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.329      P=0.417N     P=0.305      P=0.418     |P=0.125      P=0.167      P=0.300      P=0.081      | 
|POLY 3             |     P=0.348      P=0.535N     P=0.253      P=0.393     |P=0.109      P=0.183      P=0.275      P=0.071      | 
|POLY 1.5           |     P=0.354      P=0.538N     P=0.247      P=0.396     |P=0.110      P=0.185      P=0.275      P=0.072      | 
|POLY 6             |     P=0.346      P=0.527N     P=0.266      P=0.396     |P=0.111      P=0.181      P=0.274      P=0.071      | 
|LOGISTIC REGRESSION|     P=0.355      P=0.525N     P=0.254      P=0.414     |P=0.190      P=0.296      P=0.249      P=0.130      | 
|COCH-ARM / FISHERS |     P=0.352      P=0.518N     P=0.235      P=0.402     |P=0.111      P=0.188      P=0.274      P=0.074      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   8/49 (16%)   13/50 (26%)  12/50 (24%) |4/49 (8%)    8/50 (16%)   7/50 (14%)   12/49 (24%)  | 
|POLY-3 RATE (b)    |     9/46.90      8/45.11      13/48.04     12/46.52    |4/47.39      8/47.98      7/48.48      12/47.16     | 
|POLY-3 PERCENT (g) |     19.2%        17.7%        27.1%        25.8%       |8.4%         16.7%        14.4%        25.4%        | 
|TERMINAL (d)       |     5/35 (14%)   6/40 (15%)   7/40 (18%)   6/37 (16%)  |1/39 (3%)    3/36 (8%)    6/42 (14%)   8/39 (21%)   | 
|FIRST INCIDENCE    |     630          705          463          560         |624          586          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.237      P=0.417N     P=0.305      P=0.336     |P=0.041 *    P=0.167      P=0.300      P=0.033 *    | 
|POLY 3             |     P=0.248      P=0.535N     P=0.253      P=0.303     |P=0.031 *    P=0.183      P=0.275      P=0.025 *    | 
|POLY 1.5           |     P=0.253      P=0.538N     P=0.247      P=0.306     |P=0.031 *    P=0.185      P=0.275      P=0.025 *    | 
|POLY 6             |     P=0.246      P=0.527N     P=0.266      P=0.306     |P=0.031 *    P=0.181      P=0.274      P=0.025 *    | 
|LOGISTIC REGRESSION|     P=0.254      P=0.525N     P=0.254      P=0.321     |P=0.059      P=0.296      P=0.249      P=0.048 *    | 
|COCH-ARM / FISHERS |     P=0.252      P=0.518N     P=0.235      P=0.312     |P=0.032 *    P=0.188      P=0.274      P=0.027 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  26/49 (53%)  33/50 (66%)  41/50 (82%) |18/49 (37%)  14/50 (28%)  16/50 (32%)  41/49 (84%)  | 
|POLY-3 RATE (b)    |     25/47.87     26/45.11     33/48.04     41/48.25    |18/47.61     14/47.98     16/48.48     41/47.59     | 
|POLY-3 PERCENT (g) |     52.2%        57.6%        68.7%        85.0%       |37.8%        29.2%        33.0%        86.2%        | 
|TERMINAL (d)       |     16/35 (46%)  24/40 (60%)  27/40 (68%)  31/37 (84%) |13/39 (33%)  9/36 (25%)   15/42 (36%)  34/39 (87%)  | 
|FIRST INCIDENCE    |     622          705          463          527         |624          586          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.442N     P=0.233      P=0.009 **  |P<0.001 **   P=0.354N     P=0.336N     P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.375      P=0.071      P<0.001 **  |P<0.001 **   P=0.249N     P=0.391N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.390      P=0.075      P<0.001 **  |P<0.001 **   P=0.245N     P=0.389N     P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.359      P=0.068      P<0.001 **  |P<0.001 **   P=0.256N     P=0.395N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.451      P=0.074      P<0.001 **  |P<0.001 **   P=0.208N     P=0.385N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.459      P=0.078      P<0.001 **  |P<0.001 **   P=0.238N     P=0.388N     P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  26/49 (53%)  33/50 (66%)  41/50 (82%) |18/49 (37%)  14/50 (28%)  16/50 (32%)  41/49 (84%)  | 
|POLY-3 RATE (b)    |     25/47.87     26/45.11     33/48.04     41/48.25    |18/47.61     14/47.98     16/48.48     41/47.59     | 
|POLY-3 PERCENT (g) |     52.2%        57.6%        68.7%        85.0%       |37.8%        29.2%        33.0%        86.2%        | 
|TERMINAL (d)       |     16/35 (46%)  24/40 (60%)  27/40 (68%)  31/37 (84%) |13/39 (33%)  9/36 (25%)   15/42 (36%)  34/39 (87%)  | 
|FIRST INCIDENCE    |     622          705          463          527         |624          586          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.442N     P=0.233      P=0.009 **  |P<0.001 **   P=0.354N     P=0.336N     P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.375      P=0.071      P<0.001 **  |P<0.001 **   P=0.249N     P=0.391N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.390      P=0.075      P<0.001 **  |P<0.001 **   P=0.245N     P=0.389N     P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.359      P=0.068      P<0.001 **  |P<0.001 **   P=0.256N     P=0.395N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.451      P=0.074      P<0.001 **  |P<0.001 **   P=0.208N     P=0.385N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.459      P=0.078      P<0.001 **  |P<0.001 **   P=0.238N     P=0.388N     P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  7/50 (14%)   0/50 (0%)    7/50 (14%)  |2/50 (4%)    2/50 (4%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     13/46.56     7/45.37      0/45.18      7/45.47     |2/47.55      2/46.72      2/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     27.9%        15.4%        0.0%         15.4%       |4.2%         4.3%         4.2%         0.0%         | 
|TERMINAL (d)       |     11/35 (31%)  5/40 (13%)   0/40 (0%)    5/37 (14%)  |2/39 (5%)    1/36 (3%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     622          705          ---          599         |731 (T)      630          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.067N     P<0.001N**   P=0.095N    |P=0.154N     P=0.668      P=0.668N     P=0.238N     | 
|POLY 3             |     P=0.286N     P=0.114N     P<0.001N**   P=0.113N    |P=0.167N     P=0.687      P=0.690N     P=0.248N     | 
|POLY 1.5           |     P=0.283N     P=0.116N     P<0.001N**   P=0.110N    |P=0.166N     P=0.690      P=0.692N     P=0.246N     | 
|POLY 6             |     P=0.290N     P=0.108N     P<0.001N**   P=0.114N    |P=0.166N     P=0.685      P=0.687N     P=0.247N     | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.108N     P<0.001N**   P=0.114N    |P=0.161N     P=0.681N     P=0.668N     (e)          | 
|COCH-ARM / FISHERS |     P=0.293N     P=0.105N     P<0.001N**   P=0.105N    |P=0.161N     P=0.691N     P=0.691N     P=0.253N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    1/50 (2%)    4/50 (8%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     6/46.41      3/45.21      1/45.18      4/44.71     |1/47.55      3/46.47      1/48.03      1/45.40      | 
|POLY-3 PERCENT (g) |     12.9%        6.6%         2.2%         9.0%        |2.1%         6.5%         2.1%         2.2%         | 
|TERMINAL (d)       |     4/35 (11%)   3/40 (8%)    1/40 (3%)    4/37 (11%)  |1/39 (3%)    2/36 (6%)    1/42 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     669          729 (T)      729 (T)      729 (T)     |731 (T)      705          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.574N     P=0.199N     P=0.049N*    P=0.352N    |P=0.427N     P=0.281      P=0.745N     P=0.762      | 
|POLY 3             |     P=0.569N     P=0.255N     P=0.060N     P=0.393N    |P=0.454N     P=0.297      P=0.758N     P=0.750      | 
|POLY 1.5           |     P=0.562N     P=0.256N     P=0.059N     P=0.383N    |P=0.451N     P=0.301      P=0.759N     P=0.752      | 
|POLY 6             |     P=0.578N     P=0.250N     P=0.061N     P=0.403N    |P=0.454N     P=0.293      P=0.757N     P=0.750      | 
|LOGISTIC REGRESSION|     P=0.581N     P=0.249N     P=0.060N     P=0.389N    |P=0.443N     P=0.289      P=0.745N     P=0.762      | 
|COCH-ARM / FISHERS |     P=0.560N     P=0.243N     P=0.056N     P=0.370N    |P=0.444N     P=0.309      P=0.753N     P=0.747      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  10/50 (20%)  1/50 (2%)    10/50 (20%) |3/50 (6%)    5/50 (10%)   3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     17/47.01     10/45.37     1/45.18      10/45.47    |3/47.55      5/46.83      3/48.03      1/45.40      | 
|POLY-3 PERCENT (g) |     36.2%        22.0%        2.2%         22.0%       |6.3%         10.7%        6.3%         2.2%         | 
|TERMINAL (d)       |     13/35 (37%)  8/40 (20%)   1/40 (3%)    8/37 (22%)  |3/39 (8%)    3/36 (8%)    3/42 (7%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     622          705          729 (T)      599         |731 (T)      630          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.053N     P<0.001N**   P=0.081N    |P=0.127N     P=0.320      P=0.629N     P=0.305N     | 
|POLY 3             |     P=0.284N     P=0.102N     P<0.001N**   P=0.100N    |P=0.144N     P=0.348      P=0.657N     P=0.322N     | 
|POLY 1.5           |     P=0.280N     P=0.101N     P<0.001N**   P=0.094N    |P=0.143N     P=0.352      P=0.659N     P=0.320N     | 
|POLY 6             |     P=0.291N     P=0.099N     P<0.001N**   P=0.106N    |P=0.144N     P=0.345      P=0.654N     P=0.322N     | 
|LOGISTIC REGRESSION|     P=0.308N     P=0.093N     P<0.001N**   P=0.097N    |P=0.140N     P=0.352      P=0.629N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.291N     P=0.088N     P<0.001N**   P=0.088N    |P=0.137N     P=0.357      P=0.661N     P=0.316N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      2/45.21      0/45.18      0/44.71     |1/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.392N     P=0.268      (e)          (e)         |P=0.543N     P=0.516N     P=0.485N     P=0.500N     | 
|POLY 3             |     P=0.395N     P=0.234      (e)          (e)         |P=0.549N     P=0.505N     P=0.498N     P=0.509N     | 
|POLY 1.5           |     P=0.395N     P=0.232      (e)          (e)         |P=0.549N     P=0.503N     P=0.499N     P=0.508N     | 
|POLY 6             |     P=0.394N     P=0.237      (e)          (e)         |P=0.548N     P=0.508N     P=0.496N     P=0.509N     | 
|LOGISTIC REGRESSION|     (e)          P=0.268      (e)          (e)         |P=0.543N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |P=0.551N     P=0.500N     P=0.500N     P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/49 (2%)    3/49 (6%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/47.55      1/45.91      3/47.03      1/45.05      | 
|POLY-3 PERCENT (g) |                                                        |4.2%         2.2%         6.4%         2.2%         | 
|TERMINAL (d)       |                                                        |2/39 (5%)    0/36 (0%)    3/41 (7%)    1/39 (3%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      705          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.448N     P=0.524N     P=0.523      P=0.500N     | 
|POLY 3             |                                                        |P=0.475N     P=0.512N     P=0.495      P=0.519N     | 
|POLY 1.5           |                                                        |P=0.475N     P=0.510N     P=0.493      P=0.518N     | 
|POLY 6             |                                                        |P=0.471N     P=0.514N     P=0.498      P=0.517N     | 
|LOGISTIC REGRESSION|                                                        |P=0.463N     P=0.515N     P=0.523      P=0.500N     | 
|COCH-ARM / FISHERS |                                                        |P=0.471N     P=0.508N     P=0.490      P=0.515N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Luteoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/49 (0%)    1/49 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/47.55      0/45.80      1/47.03      1/45.05      | 
|POLY-3 PERCENT (g) |                                                        |4.2%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |                                                        |2/39 (5%)    0/36 (0%)    1/41 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.646N     P=0.256N     P=0.483N     P=0.500N     | 
|POLY 3             |                                                        |P=0.664N     P=0.246N     P=0.504N     P=0.519N     | 
|POLY 1.5           |                                                        |P=0.664N     P=0.244N     P=0.505N     P=0.518N     | 
|POLY 6             |                                                        |P=0.661N     P=0.247N     P=0.501N     P=0.517N     | 
|LOGISTIC REGRESSION|                                                        |P=0.646N     (e)          P=0.483N     P=0.500N     | 
|COCH-ARM / FISHERS |                                                        |P=0.664N     P=0.253N     P=0.508N     P=0.515N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    0/48 (0%)    0/50 (0%)    0/48 (0%)   |9/48 (19%)   11/49 (22%)  12/47 (26%)  8/46 (17%)   | 
|POLY-3 RATE (b)    |     0/40.90      0/43.95      0/45.18      0/42.78     |9/46.12      11/46.14     12/45.31     8/43.26      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |19.5%        23.8%        26.5%        18.5%        | 
|TERMINAL (d)       |     0/34 (0%)    0/39 (0%)    0/40 (0%)    0/36 (0%)   |8/38 (21%)   8/36 (22%)   11/39 (28%)  6/38 (16%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |680          669          656          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.306N     P=0.353      P=0.332      P=0.501N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.386N     P=0.401      P=0.294      P=0.558N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.383N     P=0.410      P=0.293      P=0.552N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.380N     P=0.392      P=0.296      P=0.557N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.366N     P=0.384      P=0.294      P=0.545N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.369N     P=0.421      P=0.292      P=0.539N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    8/50 (16%)   1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      4/45.57      2/45.18      0/44.71     |1/47.83      8/47.26      1/48.03      2/45.55      | 
|POLY-3 PERCENT (g) |     0.0%         8.8%         4.4%         0.0%        |2.1%         16.9%        2.1%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    3/40 (8%)    2/40 (5%)    0/37 (0%)   |0/39 (0%)    5/36 (14%)   1/42 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     ---          627          729 (T)      ---         |653          533          731 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194N     P=0.077      P=0.268      (e)         |P=0.274N     P=0.017 *    P=0.750N     P=0.492      | 
|POLY 3             |     P=0.196N     P=0.059      P=0.233      (e)         |P=0.291N     P=0.015 *    P=0.760N     P=0.483      | 
|POLY 1.5           |     P=0.193N     P=0.058      P=0.235      (e)         |P=0.287N     P=0.015 *    P=0.760N     P=0.486      | 
|POLY 6             |     P=0.197N     P=0.062      P=0.234      (e)         |P=0.292N     P=0.014 *    P=0.759N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.193N     P=0.061      P=0.268      (e)         |P=0.238N     P=0.025 *    P=0.748      P=0.530      | 
|COCH-ARM / FISHERS |     P=0.190N     P=0.059      P=0.247      (e)         |P=0.281N     P=0.015 *    P=0.753N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    8/50 (16%)   1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      4/45.57      2/45.18      0/44.71     |1/47.83      8/47.26      1/48.03      2/45.55      | 
|POLY-3 PERCENT (g) |     0.0%         8.8%         4.4%         0.0%        |2.1%         16.9%        2.1%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    3/40 (8%)    2/40 (5%)    0/37 (0%)   |0/39 (0%)    5/36 (14%)   1/42 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     ---          627          729 (T)      ---         |653          533          731 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194N     P=0.077      P=0.268      (e)         |P=0.274N     P=0.017 *    P=0.750N     P=0.492      | 
|POLY 3             |     P=0.196N     P=0.059      P=0.233      (e)         |P=0.291N     P=0.015 *    P=0.760N     P=0.483      | 
|POLY 1.5           |     P=0.193N     P=0.058      P=0.235      (e)         |P=0.287N     P=0.015 *    P=0.760N     P=0.486      | 
|POLY 6             |     P=0.197N     P=0.062      P=0.234      (e)         |P=0.292N     P=0.014 *    P=0.759N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.193N     P=0.061      P=0.268      (e)         |P=0.238N     P=0.025 *    P=0.748      P=0.530      | 
|COCH-ARM / FISHERS |     P=0.190N     P=0.059      P=0.247      (e)         |P=0.281N     P=0.015 *    P=0.753N     P=0.492      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      2/45.21      2/45.18      0/44.71     |0/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    2/40 (5%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.349N     P=0.268      P=0.268      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.355N     P=0.234      P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.351N     P=0.232      P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.358N     P=0.237      P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.268      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.247      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    8/50 (16%)   1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      1/45.57      0/45.18      0/44.71     |1/47.83      8/47.26      1/48.03      2/45.55      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.1%         16.9%        2.1%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    5/36 (14%)   1/42 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     ---          627          ---          ---         |653          533          731 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.615N     P=0.491      (e)          (e)         |P=0.274N     P=0.017 *    P=0.750N     P=0.492      | 
|POLY 3             |     P=0.610N     P=0.498      (e)          (e)         |P=0.291N     P=0.015 *    P=0.760N     P=0.483      | 
|POLY 1.5           |     P=0.611N     P=0.496      (e)          (e)         |P=0.287N     P=0.015 *    P=0.760N     P=0.486      | 
|POLY 6             |     P=0.608N     P=0.503      (e)          (e)         |P=0.292N     P=0.014 *    P=0.759N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.620N     P=0.529      (e)          (e)         |P=0.238N     P=0.025 *    P=0.748      P=0.530      | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.281N     P=0.015 *    P=0.753N     P=0.492      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/44.79      1/44.30      1/45.18      0/44.71     |0/46.74      1/46.37      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     4.5%         2.3%         2.2%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    1/40 (3%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      ---         |---          730          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.220N     P=0.475N     P=0.477N     P=0.244N    |P=0.607N     P=0.489      (e)          (e)          | 
|POLY 3             |     P=0.213N     P=0.504N     P=0.497N     P=0.237N    |P=0.620N     P=0.498      (e)          (e)          | 
|POLY 1.5           |     P=0.209N     P=0.506N     P=0.492N     P=0.234N    |P=0.617N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.218N     P=0.499N     P=0.501N     P=0.242N    |P=0.622N     P=0.495      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.211N     P=0.503N     P=0.490N     P=0.227N    |P=0.607N     P=0.490      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.206N     P=0.500N     P=0.485N     P=0.237N    |P=0.614N     P=0.505      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.18      0/45.21      2/45.18      0/44.71     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         4.4%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    2/40 (5%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     669          ---          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296N     P=0.228N     P=0.662N     P=0.241N    |                                                    | 
|POLY 3             |     P=0.293N     P=0.242N     P=0.686      P=0.244N    |                                                    | 
|POLY 1.5           |     P=0.289N     P=0.243N     P=0.689      P=0.242N    |                                                    | 
|POLY 6             |     P=0.300N     P=0.239N     P=0.685      P=0.247N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.294N     P=0.238N     P=0.690      P=0.237N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.290N     P=0.247N     P=0.691N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/48 (0%)    2/49 (4%)    0/49 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/44.31      2/44.18      0/43.71     |0/46.83      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    2/39 (5%)    0/36 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.447N     P=0.473N     P=0.538      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.444N     P=0.501N     P=0.497      P=0.504N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.436N     P=0.503N     P=0.501      P=0.501N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.453N     P=0.498N     P=0.494      P=0.507N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.447N     (e)          P=0.538      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.431N     P=0.500N     P=0.508      P=0.495N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/47.55      0/46.36      2/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/36 (0%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.647N     (e)          P=0.255      (e)          | 
|POLY 3             |                                                        |P=0.662N     (e)          P=0.240      (e)          | 
|POLY 1.5           |                                                        |P=0.661N     (e)          P=0.239      (e)          | 
|POLY 6             |                                                        |P=0.660N     (e)          P=0.241      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.255      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.657N     (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Leiomyoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/47.55      0/46.36      2/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/36 (0%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.647N     (e)          P=0.255      (e)          | 
|POLY 3             |                                                        |P=0.662N     (e)          P=0.240      (e)          | 
|POLY 1.5           |                                                        |P=0.661N     (e)          P=0.239      (e)          | 
|POLY 6             |                                                        |P=0.660N     (e)          P=0.241      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.255      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.657N     (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/46.27      3/45.21      2/45.60      1/44.78     |1/47.55      3/46.37      3/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     6.5%         6.6%         4.4%         2.2%        |2.1%         6.5%         6.3%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    3/40 (8%)    1/40 (3%)    0/37 (0%)   |1/39 (3%)    2/36 (6%)    3/42 (7%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     668          729 (T)      606          711         |731 (T)      730          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.237N     P=0.619N     P=0.490N     P=0.314N    |P=0.165N     P=0.281      P=0.332      P=0.500N     | 
|POLY 3             |     P=0.232N     P=0.652      P=0.507N     P=0.317N    |P=0.183N     P=0.296      P=0.309      P=0.509N     | 
|POLY 1.5           |     P=0.227N     P=0.650      P=0.504N     P=0.312N    |P=0.181N     P=0.300      P=0.308      P=0.508N     | 
|POLY 6             |     P=0.237N     P=0.657      P=0.506N     P=0.321N    |P=0.182N     P=0.292      P=0.312      P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.224N     P=0.657      P=0.496N     P=0.308N    |P=0.164N     P=0.285      P=0.332      (e)          | 
|COCH-ARM / FISHERS |     P=0.223N     P=0.661N     P=0.500N     P=0.309N    |P=0.176N     P=0.309      P=0.309      P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/46.27      3/45.21      3/45.60      1/44.78     |1/47.55      3/46.37      3/48.03      1/45.89      | 
|POLY-3 PERCENT (g) |     8.6%         6.6%         6.6%         2.2%        |2.1%         6.5%         6.3%         2.2%         | 
|TERMINAL (d)       |     2/35 (6%)    3/40 (8%)    2/40 (5%)    0/37 (0%)   |1/39 (3%)    2/36 (6%)    3/42 (7%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     668          729 (T)      606          711         |731 (T)      730          731 (T)      585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168N     P=0.449N     P=0.471N     P=0.185N    |P=0.385N     P=0.281      P=0.332      P=0.751      | 
|POLY 3             |     P=0.164N     P=0.513N     P=0.508N     P=0.189N    |P=0.403N     P=0.296      P=0.309      P=0.753      | 
|POLY 1.5           |     P=0.159N     P=0.514N     P=0.505N     P=0.185N    |P=0.403N     P=0.300      P=0.308      P=0.753      | 
|POLY 6             |     P=0.169N     P=0.507N     P=0.507N     P=0.192N    |P=0.399N     P=0.292      P=0.312      P=0.754      | 
|LOGISTIC REGRESSION|     P=0.159N     P=0.506N     P=0.499N     P=0.184N    |P=0.395N     P=0.285      P=0.332      P=0.704N     | 
|COCH-ARM / FISHERS |     P=0.156N     P=0.500N     P=0.500N     P=0.181N    |P=0.398N     P=0.309      P=0.309      P=0.747      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    6/50 (12%)   3/50 (6%)   |13/50 (26%)  15/50 (30%)  10/50 (20%)  7/49 (14%)   | 
|POLY-3 RATE (b)    |     3/46.18      1/45.21      6/45.92      3/44.71     |13/47.87     15/47.00     10/48.03     7/45.68      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         13.1%        6.7%        |27.2%        31.9%        20.8%        15.3%        | 
|TERMINAL (d)       |     2/35 (6%)    1/40 (3%)    4/40 (10%)   3/37 (8%)   |10/39 (26%)  13/36 (36%)  10/42 (24%)  5/39 (13%)   | 
|FIRST INCIDENCE    |     669          729 (T)      606          729 (T)     |680          533          731 (T)      666          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.507      P=0.274N     P=0.281      P=0.646N    |P=0.043N*    P=0.329      P=0.258N     P=0.117N     | 
|POLY 3             |     P=0.507      P=0.313N     P=0.239      P=0.647     |P=0.057N     P=0.389      P=0.313N     P=0.126N     | 
|POLY 1.5           |     P=0.518      P=0.314N     P=0.240      P=0.653     |P=0.056N     P=0.400      P=0.316N     P=0.123N     | 
|POLY 6             |     P=0.493      P=0.308N     P=0.243      P=0.642     |P=0.055N     P=0.372      P=0.310N     P=0.125N     | 
|LOGISTIC REGRESSION|     P=0.517      P=0.310N     P=0.243      P=0.649     |P=0.055N     P=0.373      P=0.286N     P=0.126N     | 
|COCH-ARM / FISHERS |     P=0.522      P=0.309N     P=0.243      P=0.661N    |P=0.052N     P=0.412      P=0.318N     P=0.115N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/50 (60%)  28/50 (56%)  30/50 (60%)  39/50 (78%) |25/50 (50%)  24/50 (48%)  28/50 (56%)  39/49 (80%)  | 
|POLY-3 RATE (b)    |     30/47.38     28/45.62     30/45.60     39/47.37    |25/47.96     24/47.85     28/48.81     39/47.15     | 
|POLY-3 PERCENT (g) |     63.3%        61.4%        65.8%        82.3%       |52.1%        50.2%        57.4%        82.7%        | 
|TERMINAL (d)       |     23/35 (66%)  25/40 (63%)  28/40 (70%)  31/37 (84%) |22/39 (56%)  17/36 (47%)  25/42 (60%)  33/39 (85%)  | 
|FIRST INCIDENCE    |     622          663          642          527         |680          602          600          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.205N     P=0.319N     P=0.102     |P=0.002 **   P=0.514      P=0.483      P=0.004 **   | 
|POLY 3             |     P=0.009 **   P=0.508N     P=0.487      P=0.027 *   |P<0.001 **   P=0.505N     P=0.376      P<0.001 **   | 
|POLY 1.5           |     P=0.010 *    P=0.497N     P=0.531      P=0.030 *   |P<0.001 **   P=0.504N     P=0.362      P<0.001 **   | 
|POLY 6             |     P=0.009 **   P=0.508N     P=0.447      P=0.025 *   |P<0.001 **   P=0.500N     P=0.398      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.004 **   P=0.440N     P=0.515      P=0.022 *   |P<0.001 **   P=0.560N     P=0.377      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.011 *    P=0.420N     P=0.581N     P=0.041 *   |P<0.001 **   P=0.500N     P=0.344      P=0.002 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/04/02                           EXPERIMENT: 90004 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            PROPYLENE GLYCOL MONO-T-BUTYL ET     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  20/50 (40%)  26/50 (52%)  18/50 (36%) |23/50 (46%)  30/50 (60%)  21/50 (42%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     22/48.48     20/46.26     26/49.55     18/46.52    |23/49.00     30/49.37     21/48.89     23/47.44     | 
|POLY-3 PERCENT (g) |     45.4%        43.2%        52.5%        38.7%       |46.9%        60.8%        43.0%        48.5%        | 
|TERMINAL (d)       |     11/35 (31%)  16/40 (40%)  17/40 (43%)  12/37 (32%) |15/39 (39%)  18/36 (50%)  17/42 (41%)  17/39 (44%)  | 
|FIRST INCIDENCE    |     610          568          451          560         |624          533          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290N     P=0.311N     P=0.409      P=0.286N    |P=0.329N     P=0.105      P=0.337N     P=0.552      | 
|POLY 3             |     P=0.263N     P=0.499N     P=0.309      P=0.326N    |P=0.389N     P=0.119      P=0.424N     P=0.521      | 
|POLY 1.5           |     P=0.239N     P=0.483N     P=0.301      P=0.301N    |P=0.379N     P=0.117      P=0.422N     P=0.528      | 
|POLY 6             |     P=0.294N     P=0.514N     P=0.317      P=0.357N    |P=0.396N     P=0.122      P=0.429N     P=0.516      | 
|LOGISTIC REGRESSION|     P=0.226N     P=0.442N     P=0.307      P=0.269N    |P=0.323N     P=0.144      P=0.431N     P=0.576      | 
|COCH-ARM / FISHERS |     P=0.227N     P=0.420N     P=0.274      P=0.270N    |P=0.360N     P=0.115      P=0.420N     P=0.543      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  38/50 (76%)  41/50 (82%)  43/50 (86%) |37/50 (74%)  39/50 (78%)  37/50 (74%)  47/49 (96%)  | 
|POLY-3 RATE (b)    |     41/49.06     38/46.51     41/49.55     43/48.25    |37/49.00     39/49.60     37/49.17     47/48.32     | 
|POLY-3 PERCENT (g) |     83.6%        81.7%        82.8%        89.1%       |75.5%        78.6%        75.3%        97.3%        | 
|TERMINAL (d)       |     27/35 (77%)  33/40 (83%)  32/40 (80%)  33/37 (89%) |29/39 (74%)  26/36 (72%)  32/42 (76%)  38/39 (97%)  | 
|FIRST INCIDENCE    |     610          568          451          527         |624          533          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225      P=0.140N     P=0.329N     P=0.508     |P=0.036 *    P=0.269      P=0.393N     P=0.035 *    | 
|POLY 3             |     P=0.199      P=0.512N     P=0.563N     P=0.306     |P<0.001 **   P=0.448      P=0.582N     P<0.001 **   | 
|POLY 1.5           |     P=0.216      P=0.461N     P=0.562N     P=0.343     |P<0.001 **   P=0.430      P=0.584N     P<0.001 **   | 
|POLY 6             |     P=0.182      P=0.570N     P=0.581N     P=0.265     |P<0.001 **   P=0.477      P=0.582N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.200      P=0.400N     P=0.599      P=0.339     |P=0.002 **   P=0.410      P=0.567N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.210      P=0.312N     P=0.602N     P=0.393     |P=0.002 **   P=0.408      P=0.590N     P=0.002 **   | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).