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TDMS Study 90004-06 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 01/09/02       
EXPERIMENT: 90004 TEST: 06                                                                                     TIME: 09:32:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: MISSING                                                                                           CAS: 57018-52-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF           PROPYLENE GLYCOL MONO-T-BUTYL ET                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hypertrophy                                                                                  
Eye: Cornea                            Mineralization                                                                               
Harderian Gland                        Hyperplasia                                                                                  
Kidney                                 Metaplasia Osseous                                                                           
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Inflammation Granulomatous                                                                   
                                       Mixed Cell Focus                                                                             
Liver: Hepatocyte                      Multinucleated                                                                               
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Mesentery: Artery                      Inflammation                                                                                 
Nose                                   Inflammation                                                                                 
Stomach, Forestomach                   Inflammation                                                                                 
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Tooth                                  Inflammation Chronic                                                                         
                                       Malformation                                                                                 
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hypertrophy                                                                                  
Eye                                    Cataract                                                                                     
Eye: Cornea                            Erosion                                                                                      
                                       Mineralization                                                                               
Intestine Small, Ileum                 Necrosis                                                                                     
Liver                                  Eosinophilic Focus                                                                           
                                       Inflammation Granulomatous                                                                   
Lung                                   Inflammation Granulomatous                                                                   
Lung: Artery                           Inflammation Acute                                                                           
Mesentery: Fat                         Necrosis                                                                                     
Tooth                                  Inflammation Chronic                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/48 (23%)  9/49 (18%)   14/50 (28%)  7/50 (14%)  |8/49 (16%)   3/50 (6%)    3/50 (6%)    4/48 (8%)    | 
|POLY-3 RATE (b)    |     11/45.10     9/44.95      14/45.28     7/45.04     |8/46.92      3/46.72      3/48.03      4/45.05      | 
|POLY-3 PERCENT (g) |     24.4%        20.0%        30.9%        15.5%       |17.1%        6.4%         6.3%         8.9%         | 
|TERMINAL (d)       |     9/35 (26%)   9/40 (23%)   13/40 (33%)  6/37 (16%)  |7/39 (18%)   2/36 (6%)    3/42 (7%)    4/39 (10%)   | 
|FIRST INCIDENCE    |     641          729 (T)      702          637         |683          630          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198N     P=0.292N     P=0.450      P=0.195N    |P=0.346N     P=0.128N     P=0.082N     P=0.180N     | 
|POLY 3             |     P=0.186N     P=0.404N     P=0.323      P=0.215N    |P=0.379N     P=0.100N     P=0.092N     P=0.197N     | 
|POLY 1.5           |     P=0.173N     P=0.405N     P=0.342      P=0.204N    |P=0.380N     P=0.097N     P=0.092N     P=0.195N     | 
|POLY 6             |     P=0.202N     P=0.400N     P=0.308      P=0.228N    |P=0.375N     P=0.103N     P=0.090N     P=0.197N     | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.381N     P=0.327      P=0.214N    |P=0.377N     P=0.099N     P=0.088N     P=0.189N     | 
|COCH-ARM / FISHERS |     P=0.166N     P=0.381N     P=0.365      P=0.190N    |P=0.377N     P=0.094N     P=0.094N     P=0.188N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/48 (71%)  32/49 (65%)  29/50 (58%)  18/50 (36%) |7/49 (14%)   7/50 (14%)   1/50 (2%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     34/45.63     32/45.31     29/45.74     18/46.09    |7/46.74      7/46.77      1/48.03      2/45.05      | 
|POLY-3 PERCENT (g) |     74.5%        70.6%        63.4%        39.1%       |15.0%        15.0%        2.1%         4.4%         | 
|TERMINAL (d)       |     28/35 (80%)  31/40 (78%)  27/40 (68%)  15/37 (41%) |7/39 (18%)   3/36 (8%)    1/42 (2%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     634          627          596          527         |731 (T)      669          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.131N     P=0.054N     P<0.001N**  |P=0.054N     P=0.556      P=0.025N*    P=0.079N     | 
|POLY 3             |     P<0.001N**   P=0.427N     P=0.170N     P<0.001N**  |P=0.059N     P=0.613N     P=0.027N*    P=0.088N     | 
|POLY 1.5           |     P<0.001N**   P=0.424N     P=0.149N     P<0.001N**  |P=0.059N     P=0.606N     P=0.028N*    P=0.087N     | 
|POLY 6             |     P<0.001N**   P=0.427N     P=0.196N     P<0.001N**  |P=0.058N     P=0.608      P=0.027N*    P=0.087N     | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.349N     P=0.188N     P<0.001N**  |P=0.057N     P=0.594      P=0.025N*    P=0.079N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.357N     P=0.132N     P<0.001N**  |P=0.060N     P=0.597N     P=0.028N*    P=0.084N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    3/50 (6%)    3/50 (6%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      0/44.71     |0/46.74      3/46.36      3/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         6.5%         6.3%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    3/36 (8%)    3/42 (7%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.239N     P=0.107      P=0.135      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.261N     P=0.117      P=0.124      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.259N     P=0.120      P=0.123      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.259N     P=0.114      P=0.125      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.107      P=0.135      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.256N     P=0.125      P=0.125      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/49 (2%)    1/49 (2%)    2/49 (4%)   |2/47 (4%)    4/49 (8%)    1/50 (2%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/43.63      1/44.95      1/45.48      2/44.37     |2/45.27      4/45.56      1/48.03      3/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         4.5%        |4.4%         8.8%         2.1%         6.6%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    0/37 (0%)   |1/38 (3%)    3/35 (9%)    1/42 (2%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      564          632         |691          680          731 (T)      632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      P=0.527      P=0.487      P=0.235     |P=0.563      P=0.308      P=0.474N     P=0.499      | 
|POLY 3             |     P=0.214      P=0.506      P=0.508      P=0.241     |P=0.544      P=0.340      P=0.479N     P=0.501      | 
|POLY 1.5           |     P=0.217      P=0.505      P=0.509      P=0.243     |P=0.545      P=0.347      P=0.479N     P=0.503      | 
|POLY 6             |     P=0.212      P=0.508      P=0.509      P=0.240     |P=0.546      P=0.330      P=0.480N     P=0.502      | 
|LOGISTIC REGRESSION|     P=0.215      P=0.527      P=0.441      P=0.254     |P=0.555      P=0.351      P=0.478N     P=0.539      | 
|COCH-ARM / FISHERS |     P=0.220      P=0.510      P=0.510      P=0.258     |P=0.549      P=0.359      P=0.477N     P=0.510      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      0/44.71     |0/47.55      0/46.36      0/48.03      2/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.238      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.037 *    (e)          (e)          P=0.225      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.037 *    (e)          (e)          P=0.226      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.226      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.238      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.237      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      1/45.06     |0/47.55      0/46.36      0/48.03      3/45.53      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |0.0%         0.0%         0.0%         6.6%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          632         |---          ---          ---          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227      (e)          (e)          P=0.491     |P=0.008 **   (e)          (e)          P=0.118      | 
|POLY 3             |     P=0.229      (e)          (e)          P=0.502     |P=0.007 **   (e)          (e)          P=0.111      | 
|POLY 1.5           |     P=0.231      (e)          (e)          P=0.505     |P=0.007 **   (e)          (e)          P=0.111      | 
|POLY 6             |     P=0.226      (e)          (e)          P=0.500     |P=0.007 **   (e)          (e)          P=0.113      | 
|LOGISTIC REGRESSION|     P=0.223      (e)          (e)          P=0.518     |P=0.011 *    (e)          (e)          P=0.133      | 
|COCH-ARM / FISHERS |     P=0.232      (e)          (e)          P=0.510     |P=0.007 **   (e)          (e)          P=0.114      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/44.95      0/45.18      1/44.71     |1/47.55      2/46.68      0/48.03      2/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.2%        |2.1%         4.3%         0.0%         4.4%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |1/39 (3%)    1/36 (3%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |731 (T)      643          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.519      P=0.473N     P=0.473N     P=0.749N    |P=0.453      P=0.476      P=0.485N     P=0.500      | 
|POLY 3             |     P=0.523      P=0.498N     P=0.497N     P=0.760N    |P=0.431      P=0.494      P=0.498N     P=0.481      | 
|POLY 1.5           |     P=0.528      P=0.499N     P=0.495N     P=0.756N    |P=0.432      P=0.496      P=0.499N     P=0.482      | 
|POLY 6             |     P=0.518      P=0.496N     P=0.498N     P=0.758     |P=0.432      P=0.491      P=0.496N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.519      (e)          (e)          P=0.749N    |P=0.436      P=0.524      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.529      P=0.495N     P=0.490N     P=0.742N    |P=0.435      P=0.500      P=0.500N     P=0.485      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/49 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    4/48 (8%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/44.95      1/45.18      1/44.71     |1/47.55      2/46.68      0/48.03      4/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         2.2%        |2.1%         4.3%         0.0%         8.9%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    1/40 (3%)    1/37 (3%)   |1/39 (3%)    1/36 (3%)    0/42 (0%)    4/39 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |731 (T)      643          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560      P=0.473N     P=0.732N     P=0.749N    |P=0.082      P=0.476      P=0.485N     P=0.179      | 
|POLY 3             |     P=0.561      P=0.498N     P=0.758N     P=0.760N    |P=0.069      P=0.494      P=0.498N     P=0.163      | 
|POLY 1.5           |     P=0.568      P=0.499N     P=0.755N     P=0.756N    |P=0.070      P=0.496      P=0.499N     P=0.164      | 
|POLY 6             |     P=0.553      P=0.496N     P=0.759N     P=0.758     |P=0.070      P=0.491      P=0.496N     P=0.164      | 
|LOGISTIC REGRESSION|     P=0.560      (e)          P=0.732N     P=0.749N    |P=0.071      P=0.524      (e)          P=0.179      | 
|COCH-ARM / FISHERS |     P=0.571      P=0.495N     P=0.742N     P=0.742N    |P=0.072      P=0.500      P=0.500N     P=0.168      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    20/48 (42%)  | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      3/45.28     |1/47.55      2/46.68      0/48.03      20/45.61     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.6%        |2.1%         4.3%         0.0%         43.9%        | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |1/39 (3%)    1/36 (3%)    0/42 (0%)    17/39 (44%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          632         |731 (T)      643          ---          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   (e)          (e)          P=0.125     |P<0.001 **   P=0.476      P=0.485N     P<0.001 **   | 
|POLY 3             |     P=0.008 **   (e)          (e)          P=0.121     |P<0.001 **   P=0.494      P=0.498N     P<0.001 **   | 
|POLY 1.5           |     P=0.008 **   (e)          (e)          P=0.123     |P<0.001 **   P=0.496      P=0.499N     P<0.001 **   | 
|POLY 6             |     P=0.008 **   (e)          (e)          P=0.120     |P<0.001 **   P=0.491      P=0.496N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.009 **   (e)          (e)          P=0.133     |P<0.001 **   P=0.524      (e)          P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.009 **   (e)          (e)          P=0.129     |P<0.001 **   P=0.500      P=0.500N     P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/38 (0%)    1/41 (2%)    2/39 (5%)    0/40 (0%)   |0/40 (0%)    0/39 (0%)    0/43 (0%)    0/33 (0%)    | 
|POLY-3 RATE (b)    |     0/37.41      1/37.55      2/36.29      0/37.01     |0/38.42      0/36.72      0/41.99      0/31.44      | 
|POLY-3 PERCENT (g) |     0.0%         2.7%         5.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    1/34 (3%)    1/33 (3%)    0/31 (0%)   |0/33 (0%)    0/31 (0%)    0/38 (0%)    0/29 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      642          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493N     P=0.500      P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.485N     P=0.501      P=0.230      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.476N     P=0.503      P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.497N     P=0.498      P=0.226      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.468N     P=0.500      P=0.285      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.519      P=0.253      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  3/50 (6%)    5/50 (10%)   1/50 (2%)   |3/50 (6%)    3/50 (6%)    4/50 (8%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     10/46.66     3/45.21      5/45.28      1/44.71     |3/47.55      3/47.04      4/48.03      4/46.08      | 
|POLY-3 PERCENT (g) |     21.4%        6.6%         11.0%        2.2%        |6.3%         6.4%         8.3%         8.7%         | 
|TERMINAL (d)       |     7/35 (20%)   3/40 (8%)    4/40 (10%)   1/37 (3%)   |3/39 (8%)    1/36 (3%)    4/42 (10%)   3/39 (8%)    | 
|FIRST INCIDENCE    |     610          729 (T)      702          729 (T)     |731 (T)      586          731 (T)      501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.021N*    P=0.026N*    P=0.100N     P=0.006N**  |P=0.443      P=0.629      P=0.541      P=0.497      | 
|POLY 3             |     P=0.018N*    P=0.039N*    P=0.143N     P=0.005N**  |P=0.422      P=0.657      P=0.506      P=0.483      | 
|POLY 1.5           |     P=0.017N*    P=0.040N*    P=0.137N     P=0.005N**  |P=0.422      P=0.659      P=0.503      P=0.484      | 
|POLY 6             |     P=0.020N*    P=0.038N*    P=0.145N     P=0.005N**  |P=0.426      P=0.656      P=0.510      P=0.486      | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.039N*    P=0.137N     P=0.006N**  |P=0.474      P=0.624N     P=0.541      P=0.529      | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.036N*    P=0.131N     P=0.004N**  |P=0.426      P=0.661N     P=0.500      P=0.489      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   8/50 (16%)   11/50 (22%)  7/50 (14%)  |5/50 (10%)   4/50 (8%)    8/50 (16%)   3/49 (6%)    | 
|POLY-3 RATE (b)    |     9/46.31      8/45.21      11/45.50     7/45.50     |5/47.66      4/46.51      8/48.26      3/45.44      | 
|POLY-3 PERCENT (g) |     19.4%        17.7%        24.2%        15.4%       |10.5%        8.6%         16.6%        6.6%         | 
|TERMINAL (d)       |     8/35 (23%)   8/40 (20%)   10/40 (25%)  4/37 (11%)  |4/39 (10%)   3/36 (8%)    7/42 (17%)   2/39 (5%)    | 
|FIRST INCIDENCE    |     630          729 (T)      641          527         |701          694          669          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.361N     P=0.390N     P=0.513      P=0.366N    |P=0.280N     P=0.545N     P=0.321      P=0.358N     | 
|POLY 3             |     P=0.349N     P=0.522N     P=0.383      P=0.407N    |P=0.315N     P=0.515N     P=0.284      P=0.383N     | 
|POLY 1.5           |     P=0.342N     P=0.524N     P=0.391      P=0.402N    |P=0.313N     P=0.509N     P=0.281      P=0.379N     | 
|POLY 6             |     P=0.356N     P=0.512N     P=0.384      P=0.409N    |P=0.312N     P=0.523N     P=0.290      P=0.384N     | 
|LOGISTIC REGRESSION|     P=0.366N     P=0.486N     P=0.385      P=0.404N    |P=0.308N     P=0.526N     P=0.286      P=0.377N     | 
|COCH-ARM / FISHERS |     P=0.344N     P=0.500N     P=0.402      P=0.393N    |P=0.303N     P=0.500N     P=0.277      P=0.369N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/46.98      0/45.21      0/45.18      0/44.71     |0/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     281          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.239N     P=0.237N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.301N     P=0.246N     P=0.246N     P=0.248N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.301N     P=0.246N     P=0.243N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.304N     P=0.243N     P=0.246N     P=0.251N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.362N     P=0.118N     P=0.254N     P=0.202N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/45.21      3/45.63      0/44.71     |1/47.55      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.6%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    2/40 (5%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          596          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.587N     (e)          P=0.134      (e)         |P=0.543N     P=0.516N     P=0.485N     P=0.500N     | 
|POLY 3             |     P=0.591N     (e)          P=0.117      (e)         |P=0.549N     P=0.505N     P=0.498N     P=0.509N     | 
|POLY 1.5           |     P=0.585N     (e)          P=0.118      (e)         |P=0.549N     P=0.503N     P=0.499N     P=0.508N     | 
|POLY 6             |     P=0.598N     (e)          P=0.119      (e)         |P=0.548N     P=0.508N     P=0.496N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.582N     (e)          P=0.122      (e)         |P=0.543N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.581N     (e)          P=0.121      (e)         |P=0.551N     P=0.500N     P=0.500N     P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/43 (2%)    1/47 (2%)    0/48 (0%)    0/48 (0%)   |0/49 (0%)    0/48 (0%)    2/49 (4%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     1/40.70      1/43.90      0/44.33      0/43.70     |0/46.74      0/44.86      2/47.36      0/43.38      | 
|POLY-3 PERCENT (g) |     2.5%         2.3%         0.0%         0.0%        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    1/41 (2%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     711          568          ---          ---         |---          ---          641          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355N     P=0.759N     P=0.490N     P=0.500N    |P=0.654N     (e)          P=0.250      (e)          | 
|POLY 3             |     P=0.339N     P=0.744N     P=0.483N     P=0.486N    |P=0.667N     (e)          P=0.240      (e)          | 
|POLY 1.5           |     P=0.337N     P=0.745N     P=0.480N     P=0.482N    |P=0.668N     (e)          P=0.239      (e)          | 
|POLY 6             |     P=0.340N     P=0.742N     P=0.485N     P=0.490N    |P=0.663N     (e)          P=0.242      (e)          | 
|LOGISTIC REGRESSION|     P=0.345N     P=0.721N     P=0.479N     P=0.481N    |P=0.626N     (e)          P=0.217      (e)          | 
|COCH-ARM / FISHERS |     P=0.336N     P=0.730N     P=0.473N     P=0.473N    |P=0.666N     (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Ileum                                                                                                           | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/43 (9%)    2/47 (4%)    2/46 (4%)    1/46 (2%)   |2/49 (4%)    1/48 (2%)    3/48 (6%)    1/45 (2%)    | 
|POLY-3 RATE (b)    |     4/40.63      2/43.37      2/43.20      1/42.64     |2/46.74      1/44.98      3/46.31      1/42.63      | 
|POLY-3 PERCENT (g) |     9.8%         4.6%         4.6%         2.4%        |4.3%         2.2%         6.5%         2.4%         | 
|TERMINAL (d)       |     4/35 (11%)   2/40 (5%)    2/40 (5%)    1/37 (3%)   |2/39 (5%)    1/36 (3%)    3/41 (7%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209N     P=0.277N     P=0.277N     P=0.162N    |P=0.447N     P=0.528N     P=0.523      P=0.500N     | 
|POLY 3             |     P=0.200N     P=0.307N     P=0.309N     P=0.163N    |P=0.490N     P=0.513N     P=0.496      P=0.532N     | 
|POLY 1.5           |     P=0.198N     P=0.307N     P=0.307N     P=0.161N    |P=0.492N     P=0.511N     P=0.493      P=0.532N     | 
|POLY 6             |     P=0.203N     P=0.305N     P=0.311N     P=0.166N    |P=0.483N     P=0.516N     P=0.500      P=0.528N     | 
|LOGISTIC REGRESSION|     P=0.209N     P=0.277N     P=0.277N     P=0.162N    |P=0.447N     P=0.528N     P=0.523      P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.297N     P=0.306N     P=0.160N    |P=0.491N     P=0.508N     P=0.490      P=0.532N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Ileum                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    0/47 (0%)    1/46 (2%)    0/46 (0%)   |0/49 (0%)    0/48 (0%)    0/48 (0%)    2/45 (4%)    | 
|POLY-3 RATE (b)    |     0/40.63      0/43.37      1/43.20      0/42.64     |0/46.74      0/44.98      0/46.31      2/43.90      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/40 (3%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/41 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.777N     (e)          P=0.527      (e)         |P=0.039 *    (e)          (e)          P=0.228      | 
|POLY 3             |     P=0.770N     (e)          P=0.512      (e)         |P=0.036 *    (e)          (e)          P=0.223      | 
|POLY 1.5           |     P=0.768N     (e)          P=0.513      (e)         |P=0.036 *    (e)          (e)          P=0.221      | 
|POLY 6             |     P=0.772N     (e)          P=0.511      (e)         |P=0.038 *    (e)          (e)          P=0.228      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.527      (e)         |P=0.319      (e)          (e)          P=0.704      | 
|COCH-ARM / FISHERS |     P=0.769N     (e)          P=0.517      (e)         |P=0.036 *    (e)          (e)          P=0.226      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/42 (5%)    0/47 (0%)    2/47 (4%)    0/45 (0%)   |0/49 (0%)    0/48 (0%)    1/48 (2%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/39.71      0/43.37      2/44.10      0/41.86     |0/46.74      0/44.98      1/46.36      0/44.24      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    2/40 (5%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    1/42 (2%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.209N     P=0.646N     P=0.226N    |P=0.770N     (e)          P=0.515      (e)          | 
|POLY 3             |     P=0.284N     P=0.217N     P=0.656N     P=0.225N    |P=0.778N     (e)          P=0.498      (e)          | 
|POLY 1.5           |     P=0.281N     P=0.217N     P=0.653N     P=0.224N    |P=0.778N     (e)          P=0.497      (e)          | 
|POLY 6             |     P=0.286N     P=0.217N     P=0.659N     P=0.227N    |P=0.776N     (e)          P=0.500      (e)          | 
|LOGISTIC REGRESSION|     P=0.292N     (e)          P=0.646N     (e)         |(e)          (e)          P=0.515      (e)          | 
|COCH-ARM / FISHERS |     P=0.286N     P=0.220N     P=0.648N     P=0.230N    |P=0.778N     (e)          P=0.495      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/45.96      1/44.95      2/45.18      0/44.71     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    2/40 (5%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320N     P=0.732N     P=0.547      P=0.489N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.324N     P=0.756      P=0.494      P=0.505N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.319N     P=0.753      P=0.496      P=0.503N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.330N     P=0.760      P=0.495      P=0.507N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.320N     P=0.732N     P=0.547      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.315N     P=0.747      P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/49 (6%)    3/50 (6%)    7/50 (14%)  |1/49 (2%)    0/50 (0%)    2/50 (4%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     3/46.26      3/44.95      3/45.18      7/45.03     |1/46.74      0/46.36      2/48.03      3/45.05      | 
|POLY-3 PERCENT (g) |     6.5%         6.7%         6.6%         15.6%       |2.1%         0.0%         4.2%         6.7%         | 
|TERMINAL (d)       |     1/35 (3%)    3/40 (8%)    3/40 (8%)    6/37 (16%)  |1/39 (3%)    0/36 (0%)    2/42 (5%)    3/39 (8%)    | 
|FIRST INCIDENCE    |     669          729 (T)      729 (T)      643         |731 (T)      ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060      P=0.615N     P=0.619N     P=0.174     |P=0.118      P=0.516N     P=0.526      P=0.305      | 
|POLY 3             |     P=0.062      P=0.649      P=0.651      P=0.146     |P=0.106      P=0.502N     P=0.509      P=0.292      | 
|POLY 1.5           |     P=0.065      P=0.645      P=0.656      P=0.151     |P=0.106      P=0.499N     P=0.508      P=0.294      | 
|POLY 6             |     P=0.059      P=0.656      P=0.650      P=0.142     |P=0.109      P=0.505N     P=0.511      P=0.293      | 
|LOGISTIC REGRESSION|     P=0.058      P=0.653      P=0.656      P=0.148     |P=0.118      (e)          P=0.526      P=0.305      | 
|COCH-ARM / FISHERS |     P=0.067      P=0.651      P=0.661N     P=0.159     |P=0.106      P=0.495N     P=0.508      P=0.301      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    6/49 (12%)   2/50 (4%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     3/46.02      6/45.31      2/45.28      0/44.71     |2/46.74      1/46.36      1/48.03      1/45.05      | 
|POLY-3 PERCENT (g) |     6.5%         13.2%        4.4%         0.0%        |4.3%         2.2%         2.1%         2.2%         | 
|TERMINAL (d)       |     2/35 (6%)    5/40 (13%)   1/40 (3%)    0/37 (0%)   |2/39 (5%)    1/36 (3%)    1/42 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     714          627          702          ---         |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035N*    P=0.300      P=0.453N     P=0.116N    |P=0.513N     P=0.528N     P=0.474N     P=0.500N     | 
|POLY 3             |     P=0.033N*    P=0.234      P=0.507N     P=0.124N    |P=0.534N     P=0.503N     P=0.491N     P=0.513N     | 
|POLY 1.5           |     P=0.032N*    P=0.228      P=0.504N     P=0.122N    |P=0.534N     P=0.499N     P=0.492N     P=0.511N     | 
|POLY 6             |     P=0.034N*    P=0.246      P=0.506N     P=0.125N    |P=0.530N     P=0.508N     P=0.489N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.034N*    P=0.231      P=0.505N     P=0.124N    |P=0.513N     P=0.528N     P=0.474N     P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.033N*    P=0.233      P=0.500N     P=0.121N    |P=0.533N     P=0.492N     P=0.492N     P=0.508N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  40/49 (82%)  44/50 (88%)  36/50 (72%) |34/49 (69%)  34/50 (68%)  32/50 (64%)  34/48 (71%)  | 
|POLY-3 RATE (b)    |     41/48.49     40/46.25     44/50.00     36/47.18    |34/49.00     34/49.15     32/49.43     34/47.32     | 
|POLY-3 PERCENT (g) |     84.6%        86.5%        88.0%        76.3%       |69.4%        69.2%        64.7%        71.9%        | 
|TERMINAL (d)       |     33/35 (94%)  35/40 (88%)  34/40 (85%)  29/37 (78%) |24/39 (62%)  23/36 (64%)  27/42 (64%)  26/39 (67%)  | 
|FIRST INCIDENCE    |     281          568          451          527         |588          533          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185N     P=0.151N     P=0.484N     P=0.134N    |P=0.539N     P=0.413      P=0.299N     P=0.543      | 
|POLY 3             |     P=0.092N     P=0.510      P=0.417      P=0.213N    |P=0.407      P=0.577N     P=0.392N     P=0.484      | 
|POLY 1.5           |     P=0.079N     P=0.492      P=0.353      P=0.205N    |P=0.412      P=0.555N     P=0.378N     P=0.499      | 
|POLY 6             |     P=0.098N     P=0.576      P=0.535      P=0.197N    |P=0.409      P=0.562      P=0.415N     P=0.470      | 
|LOGISTIC REGRESSION|     P=0.077N     P=0.553      P=0.288      P=0.202N    |P=0.435      P=0.465N     P=0.380N     P=0.547      | 
|COCH-ARM / FISHERS |     P=0.076N     P=0.584N     P=0.288      P=0.171N    |P=0.428      P=0.527N     P=0.361N     P=0.527      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Artery                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      2/45.63      1/44.71     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/40 (3%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          596          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413      (e)          P=0.245      P=0.511     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.409      (e)          P=0.236      P=0.495     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.416      (e)          P=0.236      P=0.497     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.402      (e)          P=0.237      P=0.493     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.421      (e)          P=0.238      P=0.511     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.421      (e)          P=0.247      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      1/45.18      2/44.71     |0/46.74      0/46.36      1/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         4.5%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/40 (3%)    2/37 (5%)   |0/39 (0%)    0/36 (0%)    1/42 (2%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092      (e)          P=0.527      P=0.251     |P=0.770N     (e)          P=0.515      (e)          | 
|POLY 3             |     P=0.094      (e)          P=0.497      P=0.231     |P=0.778N     (e)          P=0.505      (e)          | 
|POLY 1.5           |     P=0.096      (e)          P=0.498      P=0.234     |P=0.778N     (e)          P=0.505      (e)          | 
|POLY 6             |     P=0.091      (e)          P=0.497      P=0.229     |P=0.777N     (e)          P=0.506      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.527      P=0.251     |(e)          (e)          P=0.515      (e)          | 
|COCH-ARM / FISHERS |     P=0.098      (e)          P=0.500      P=0.247     |P=0.778N     (e)          P=0.505      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/45.96      0/44.95      1/45.18      0/44.71     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    1/40 (3%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.302N     P=0.209N     P=0.453N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.303N     P=0.242N     P=0.506N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.299N     P=0.245N     P=0.504N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.309N     P=0.237N     P=0.505N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.302N     (e)          P=0.453N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.298N     P=0.253N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      0/45.18      2/45.03     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          643         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.238     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.041 *    (e)          (e)          P=0.233     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.040 *    (e)          (e)          P=0.232     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.043 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   11/49 (22%)  16/50 (32%)  4/50 (8%)   |3/49 (6%)    4/50 (8%)    4/50 (8%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     6/45.96      11/45.45     16/46.39     4/44.93     |3/46.86      4/46.94      4/48.31      2/45.44      | 
|POLY-3 PERCENT (g) |     13.1%        24.2%        34.5%        8.9%        |6.4%         8.5%         8.3%         4.4%         | 
|TERMINAL (d)       |     6/35 (17%)   9/40 (23%)   14/40 (35%)  3/37 (8%)   |2/39 (5%)    2/36 (6%)    3/42 (7%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      611          451          672         |701          616          655          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.085N     P=0.213      P=0.030 *    P=0.338N    |P=0.321N     P=0.465      P=0.535      P=0.500N     | 
|POLY 3             |     P=0.082N     P=0.135      P=0.013 *    P=0.384N    |P=0.343N     P=0.501      P=0.517      P=0.514N     | 
|POLY 1.5           |     P=0.076N     P=0.128      P=0.013 *    P=0.379N    |P=0.339N     P=0.505      P=0.514      P=0.510N     | 
|POLY 6             |     P=0.088N     P=0.148      P=0.013 *    P=0.385N    |P=0.344N     P=0.496      P=0.521      P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.083N     P=0.138      P=0.014 *    P=0.386N    |P=0.316N     P=0.545      P=0.507      P=0.513N     | 
|COCH-ARM / FISHERS |     P=0.077N     P=0.133      P=0.014 *    P=0.370N    |P=0.328N     P=0.511      P=0.511      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  18/49 (37%)  16/50 (32%)  17/50 (34%) |4/49 (8%)    4/50 (8%)    6/50 (12%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     20/46.18     18/44.95     16/45.79     17/44.71    |4/46.92      4/47.12      6/48.30      5/45.93      | 
|POLY-3 PERCENT (g) |     43.3%        40.1%        34.9%        38.0%       |8.5%         8.5%         12.4%        10.9%        | 
|TERMINAL (d)       |     19/35 (54%)  18/40 (45%)  15/40 (38%)  17/37 (46%) |3/39 (8%)    2/36 (6%)    5/42 (12%)   3/39 (8%)    | 
|FIRST INCIDENCE    |     671          729 (T)      531          729 (T)     |683          616          658          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.218N     P=0.124N     P=0.248N    |P=0.470      P=0.604      P=0.409      P=0.493      | 
|POLY 3             |     P=0.414N     P=0.459N     P=0.270N     P=0.381N    |P=0.446      P=0.641N     P=0.388      P=0.487      | 
|POLY 1.5           |     P=0.389N     P=0.473N     P=0.268N     P=0.364N    |P=0.448      P=0.637N     P=0.386      P=0.490      | 
|POLY 6             |     P=0.445N     P=0.431N     P=0.261N     P=0.396N    |P=0.449      P=0.641      P=0.392      P=0.487      | 
|LOGISTIC REGRESSION|     P=0.452N     P=0.305N     P=0.277N     P=0.330N    |P=0.493      P=0.580N     P=0.382      P=0.513      | 
|COCH-ARM / FISHERS |     P=0.371N     P=0.449N     P=0.266N     P=0.339N    |P=0.458      P=0.631N     P=0.383      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   14/49 (29%)  11/50 (22%)  29/50 (58%) |11/49 (22%)  10/50 (20%)  9/50 (18%)   27/49 (55%)  | 
|POLY-3 RATE (b)    |     9/45.96      14/45.01     11/45.18     29/46.40    |11/47.08     10/47.46     9/48.03      27/46.53     | 
|POLY-3 PERCENT (g) |     19.6%        31.1%        24.4%        62.5%       |23.4%        21.1%        18.7%        58.0%        | 
|TERMINAL (d)       |     9/35 (26%)   13/40 (33%)  11/40 (28%)  25/37 (68%) |10/39 (26%)  6/36 (17%)   9/42 (21%)   23/39 (59%)  | 
|FIRST INCIDENCE    |     729 (T)      712          729 (T)      526         |638          602          731 (T)      585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.272      P=0.535      P<0.001 **  |P<0.001 **   P=0.571N     P=0.333N     P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.152      P=0.384      P<0.001 **  |P<0.001 **   P=0.492N     P=0.382N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.146      P=0.391      P<0.001 **  |P<0.001 **   P=0.487N     P=0.382N     P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.165      P=0.385      P<0.001 **  |P<0.001 **   P=0.495N     P=0.381N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.231      P=0.535      P<0.001 **  |P<0.001 **   P=0.467N     P=0.365N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.157      P=0.402      P<0.001 **  |P<0.001 **   P=0.479N     P=0.382N     P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    2/50 (4%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/45.96      1/44.95      0/45.18      2/44.71     |2/47.24      1/46.97      1/48.11      1/46.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         4.5%        |4.2%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    2/37 (5%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |588          533          711          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.527      (e)          P=0.251     |P=0.534N     P=0.511N     P=0.483N     P=0.517N     | 
|POLY 3             |     P=0.150      P=0.496      (e)          P=0.231     |P=0.527N     P=0.502N     P=0.494N     P=0.508N     | 
|POLY 1.5           |     P=0.152      P=0.493      (e)          P=0.234     |P=0.527N     P=0.498N     P=0.493N     P=0.505N     | 
|POLY 6             |     P=0.148      P=0.500      (e)          P=0.229     |P=0.526N     P=0.508N     P=0.494N     P=0.509N     | 
|LOGISTIC REGRESSION|     (e)          P=0.527      (e)          P=0.251     |P=0.128N     P=0.217N     P=0.533N     P=0.146N     | 
|COCH-ARM / FISHERS |     P=0.154      P=0.495      (e)          P=0.247     |P=0.525N     P=0.492N     P=0.492N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    1/50 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/46.36      1/45.31      1/45.18      3/45.04     |0/46.74      0/46.36      1/48.11      0/45.40      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.2%         6.7%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/40 (3%)    2/37 (5%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     634          627          729 (T)      637         |---          ---          711          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.260      P=0.504N     P=0.483N     P=0.500     |P=0.768N     (e)          P=0.519      (e)          | 
|POLY 3             |     P=0.264      P=0.508N     P=0.509N     P=0.487     |P=0.776N     (e)          P=0.506      (e)          | 
|POLY 1.5           |     P=0.269      P=0.512N     P=0.505N     P=0.492     |P=0.776N     (e)          P=0.505      (e)          | 
|POLY 6             |     P=0.257      P=0.501N     P=0.511N     P=0.483     |P=0.776N     (e)          P=0.507      (e)          | 
|LOGISTIC REGRESSION|     P=0.272      P=0.484N     P=0.498N     P=0.507     |P=0.773N     (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.271      P=0.508N     P=0.500N     P=0.500     |P=0.775N     (e)          P=0.505      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   12/49 (24%)  11/50 (22%)  3/50 (6%)   |23/49 (47%)  9/50 (18%)   17/50 (34%)  12/49 (24%)  | 
|POLY-3 RATE (b)    |     9/45.96      12/45.01     11/45.18     3/44.71     |23/46.74     9/46.60      17/48.03     12/46.12     | 
|POLY-3 PERCENT (g) |     17.4%        26.7%        24.4%        6.7%        |49.2%        19.3%        35.4%        26.0%        | 
|TERMINAL (d)       |     9/35 (26%)   11/40 (28%)  11/40 (28%)  3/37 (8%)   |23/39 (59%)  8/36 (22%)   17/42 (41%)  10/39 (26%)  | 
|FIRST INCIDENCE    |     729 (T)      712          729 (T)      729 (T)     |731 (T)      669          731 (T)      501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020N*    P=0.334      P=0.423      P=0.081N    |P=0.113N     P=0.004N**   P=0.076N     P=0.015N*    | 
|POLY 3             |     P=0.022N*    P=0.208      P=0.289      P=0.107N    |P=0.137N     P<0.001N**   P=0.122N     P=0.016N*    | 
|POLY 1.5           |     P=0.020N*    P=0.201      P=0.296      P=0.104N    |P=0.141N     P<0.001N**   P=0.127N     P=0.016N*    | 
|POLY 6             |     P=0.024N*    P=0.223      P=0.289      P=0.108N    |P=0.125N     P=0.002N**   P=0.114N     P=0.014N*    | 
|LOGISTIC REGRESSION|     P=0.022N*    P=0.290      P=0.423      P=0.081N    |P=0.147N     P=0.003N**   P=0.076N     P=0.022N*    | 
|COCH-ARM / FISHERS |     P=0.021N*    P=0.212      P=0.306      P=0.100N    |P=0.146N     P=0.002N**   P=0.134N     P=0.017N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      0/45.18      4/44.71     |0/46.74      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         9.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    4/37 (11%)  |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.070     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          (e)          P=0.057     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.058     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          (e)          P=0.056     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.070     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.002 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    4/50 (8%)    2/50 (4%)   |4/49 (8%)    3/50 (6%)    6/50 (12%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/45.96      2/45.31      4/45.28      2/45.33     |4/47.22      3/46.97      6/48.39      4/46.57      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         8.8%         4.4%        |8.5%         6.4%         12.4%        8.6%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    3/40 (8%)    1/37 (3%)   |3/39 (8%)    2/36 (6%)    4/42 (10%)   2/39 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      627          702          527         |588          533          656          501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560      P=0.526      P=0.218      P=0.510     |P=0.564      P=0.534N     P=0.412      P=0.625      | 
|POLY 3             |     P=0.563      P=0.495      P=0.174      P=0.495     |P=0.558      P=0.503N     P=0.385      P=0.635      | 
|POLY 1.5           |     P=0.569      P=0.490      P=0.176      P=0.497     |P=0.556      P=0.497N     P=0.384      P=0.637      | 
|POLY 6             |     P=0.556      P=0.504      P=0.175      P=0.495     |P=0.566      P=0.511N     P=0.389      P=0.637      | 
|LOGISTIC REGRESSION|     P=0.574      P=0.494      P=0.179      P=0.513     |P=0.488N     P=0.377N     P=0.365      P=0.488N     | 
|COCH-ARM / FISHERS |     P=0.573      P=0.492      P=0.181      P=0.500     |P=0.560      P=0.489N     P=0.383      P=0.643N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    3/50 (6%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/46.90      1/45.30      1/45.60      0/44.71     |0/46.74      3/46.70      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         2.2%         0.0%        |0.0%         6.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     281          630          606          ---         |---          680          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341N     P=0.748      P=0.748      P=0.500N    |P=0.271N     P=0.116      (e)          (e)          | 
|POLY 3             |     P=0.341N     P=0.753      P=0.754      P=0.510N    |P=0.277N     P=0.119      (e)          (e)          | 
|POLY 1.5           |     P=0.337N     P=0.750      P=0.756      P=0.506N    |P=0.274N     P=0.120      (e)          (e)          | 
|POLY 6             |     P=0.345N     P=0.758      P=0.756      P=0.511N    |P=0.279N     P=0.117      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.392N     P=0.653N     P=0.777      (e)         |P=0.253N     P=0.134      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.331N     P=0.747      P=0.753N     P=0.500N    |P=0.271N     P=0.125      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  23/49 (47%)  24/50 (48%)  46/50 (92%) |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     27/46.94     23/45.71     24/47.02     46/48.69    |0/46.74      0/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     57.5%        50.3%        51.0%        94.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     23/35 (66%)  21/40 (53%)  20/40 (50%)  36/37 (97%) |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     630          611          463          325         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.118N     P=0.177N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.312N     P=0.334N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.330N     P=0.336N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.279N     P=0.321N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.298N     P=0.372N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.308N     P=0.345N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      1/45.21      0/45.18      1/44.71     |0/47.55      0/46.36      0/48.03      2/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.2%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.474      P=0.527      (e)          P=0.511     |P=0.043 *    (e)          (e)          P=0.238      | 
|POLY 3             |     P=0.471      P=0.497      (e)          P=0.495     |P=0.039 *    (e)          (e)          P=0.227      | 
|POLY 1.5           |     P=0.474      P=0.496      (e)          P=0.497     |P=0.039 *    (e)          (e)          P=0.229      | 
|POLY 6             |     P=0.470      P=0.500      (e)          P=0.493     |P=0.039 *    (e)          (e)          P=0.227      | 
|LOGISTIC REGRESSION|     (e)          P=0.527      (e)          P=0.511     |(e)          (e)          (e)          P=0.238      | 
|COCH-ARM / FISHERS |     P=0.478      P=0.500      (e)          P=0.500     |P=0.040 *    (e)          (e)          P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      3/46.27      0/45.18      0/44.71     |1/47.74      0/46.36      0/48.03      2/45.95      | 
|POLY-3 PERCENT (g) |     0.0%         6.5%         0.0%         0.0%        |2.1%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          137          ---          ---         |680          ---          ---          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.274N     P=0.138      (e)          (e)         |P=0.170      P=0.513N     P=0.509N     P=0.482      | 
|POLY 3             |     P=0.269N     P=0.120      (e)          (e)         |P=0.170      P=0.506N     P=0.499N     P=0.487      | 
|POLY 1.5           |     P=0.269N     P=0.119      (e)          (e)         |P=0.170      P=0.503N     P=0.499N     P=0.488      | 
|POLY 6             |     P=0.267N     P=0.123      (e)          (e)         |P=0.173      P=0.509N     P=0.498N     P=0.489      | 
|LOGISTIC REGRESSION|     P=0.314N     P=0.177      (e)          (e)         |P=0.255      P=0.455N     P=0.523N     P=0.601      | 
|COCH-ARM / FISHERS |     P=0.269N     P=0.121      (e)          (e)         |P=0.170      P=0.500N     P=0.500N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    4/50 (8%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     6/46.30      4/45.45      4/45.18      0/44.71     |3/47.55      2/46.36      4/48.54      3/45.44      | 
|POLY-3 PERCENT (g) |     13.0%        8.8%         8.9%         0.0%        |6.3%         4.3%         8.2%         6.6%         | 
|TERMINAL (d)       |     5/35 (14%)   3/40 (8%)    4/40 (10%)   0/37 (0%)   |3/39 (8%)    2/36 (6%)    2/42 (5%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     634          663          729 (T)      ---         |731 (T)      731 (T)      656          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020N*    P=0.312N     P=0.301N     P=0.016N*   |P=0.563      P=0.537N     P=0.528      P=0.660N     | 
|POLY 3             |     P=0.020N*    P=0.381N     P=0.385N     P=0.017N*   |P=0.535      P=0.511N     P=0.511      P=0.641      | 
|POLY 1.5           |     P=0.019N*    P=0.384N     P=0.379N     P=0.016N*   |P=0.536      P=0.507N     P=0.506      P=0.644      | 
|POLY 6             |     P=0.022N*    P=0.371N     P=0.387N     P=0.018N*   |P=0.539      P=0.517N     P=0.520      P=0.642      | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.379N     P=0.377N     P=0.019N*   |P=0.536      P=0.537N     P=0.488      P=0.659      | 
|COCH-ARM / FISHERS |     P=0.020N*    P=0.370N     P=0.370N     P=0.013N*   |P=0.544      P=0.500N     P=0.500      P=0.651      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/46.18      0/45.21      0/45.18      2/45.16     |2/47.55      1/46.36      0/48.03      3/45.60      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.4%        |4.2%         2.2%         0.0%         6.6%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |2/39 (5%)    1/36 (3%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     669          ---          ---          632         |731 (T)      731 (T)      ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169      P=0.505N     P=0.510N     P=0.487     |P=0.233      P=0.528N     P=0.222N     P=0.498      | 
|POLY 3             |     P=0.174      P=0.504N     P=0.504N     P=0.492     |P=0.217      P=0.509N     P=0.235N     P=0.481      | 
|POLY 1.5           |     P=0.176      P=0.505N     P=0.503N     P=0.495     |P=0.218      P=0.505N     P=0.236N     P=0.483      | 
|POLY 6             |     P=0.172      P=0.502N     P=0.505N     P=0.491     |P=0.219      P=0.513N     P=0.233N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.172      P=0.490N     P=0.498N     P=0.511     |P=0.215      P=0.528N     (e)          P=0.480      | 
|COCH-ARM / FISHERS |     P=0.175      P=0.500N     P=0.500N     P=0.500     |P=0.220      P=0.500N     P=0.247N     P=0.490      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Artery                                                                                                                     | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/45.21      0/45.18      0/44.71     |0/47.55      0/46.36      0/48.03      2/45.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.230      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.230      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.230      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.232      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.070      (e)          (e)          P=0.299      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/1 (0%)     0/4 (0%)     0/1 (0%)    |0/4 (0%)     2/8 (25%)    0/6 (0%)     0/2 (0%)     | 
|POLY-3 RATE (b)    |     0/1.77       0/1.00       0/2.92       0/1.00      |0/4.00       2/7.98       0/6.00       0/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         25.1%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/2 (0%)     0/1 (0%)    |0/4 (0%)     0/5 (0%)     0/6 (0%)     0/2 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          630          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.393N     P=0.237      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.602N     P=0.395      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.602N     P=0.396      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.602N     P=0.394      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.604N     P=0.424      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |1/48 (2%)    2/48 (4%)    2/48 (4%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/45.12      0/44.95      1/44.49      0/44.71     |1/45.55      2/44.68      2/46.39      1/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |2.2%         4.5%         4.3%         2.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/39 (0%)    0/37 (0%)   |1/37 (3%)    2/35 (6%)    2/42 (5%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          642          ---         |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.777N     (e)          P=0.491      (e)         |P=0.489N     P=0.481      P=0.544      P=0.750N     | 
|POLY 3             |     P=0.773N     (e)          P=0.497      (e)         |P=0.516N     P=0.493      P=0.506      P=0.758      | 
|POLY 1.5           |     P=0.770N     (e)          P=0.499      (e)         |P=0.516N     P=0.496      P=0.503      P=0.758      | 
|POLY 6             |     P=0.776N     (e)          P=0.498      (e)         |P=0.513N     P=0.490      P=0.512      P=0.760      | 
|LOGISTIC REGRESSION|     P=0.770N     (e)          P=0.604      (e)         |P=0.489N     P=0.481      P=0.544      P=0.750N     | 
|COCH-ARM / FISHERS |     P=0.767N     (e)          P=0.505      (e)         |P=0.513N     P=0.500      P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/49 (2%)    4/49 (8%)    0/50 (0%)   |0/48 (0%)    1/48 (2%)    0/48 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/45.12      1/44.95      4/44.18      0/44.71     |0/45.55      1/44.68      0/46.39      0/45.05      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         9.1%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    1/40 (3%)    4/39 (10%)   0/37 (0%)   |0/37 (0%)    1/35 (3%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.204N     P=0.453N     P=0.387      P=0.226N    |P=0.599N     P=0.489      (e)          (e)          | 
|POLY 3             |     P=0.208N     P=0.501N     P=0.327      P=0.239N    |P=0.613N     P=0.496      (e)          (e)          | 
|POLY 1.5           |     P=0.200N     P=0.503N     P=0.334      P=0.236N    |P=0.611N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.215N     P=0.496N     P=0.326      P=0.242N    |P=0.615N     P=0.495      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.453N     P=0.387      (e)         |(e)          P=0.489      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.195N     P=0.492N     P=0.349      P=0.237N    |P=0.608N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/14 (14%)   1/16 (6%)    4/13 (31%)   1/11 (9%)   |0/17 (0%)    0/21 (0%)    0/13 (0%)    0/2 (0%)     | 
|POLY-3 RATE (b)    |     2/13.38      1/15.65      4/11.68      1/9.75      |0/16.70      0/18.97      0/12.32      0/1.81       | 
|POLY-3 PERCENT (g) |     15.0%        6.4%         34.3%        10.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/11 (18%)   1/15 (7%)    4/10 (40%)   1/8 (13%)   |0/15 (0%)    0/12 (0%)    0/10 (0%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.649N     P=0.389N     P=0.272      P=0.616N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.622N     P=0.444N     P=0.257      P=0.612N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.601N     P=0.448N     P=0.267      P=0.601N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.647      P=0.437N     P=0.250      P=0.624N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.649N     P=0.389N     P=0.272      P=0.616N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.572N     P=0.448N     P=0.286      P=0.593N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/14 (0%)    0/16 (0%)    1/13 (8%)    2/11 (18%)  |0/17 (0%)    0/21 (0%)    0/13 (0%)    0/2 (0%)     | 
|POLY-3 RATE (b)    |     0/13.38      0/15.65      1/12.13      2/10.37     |0/16.70      0/18.97      0/12.32      0/1.81       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.2%         19.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/11 (0%)    0/15 (0%)    0/10 (0%)    1/8 (13%)   |0/15 (0%)    0/12 (0%)    0/10 (0%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          596          527         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075      (e)          P=0.487      P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          P=0.480      P=0.171     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.048 *    (e)          P=0.481      P=0.172     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.045 *    (e)          P=0.483      P=0.168     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.102      (e)          P=0.701      P=0.374     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.051      (e)          P=0.481      P=0.183     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/14 (71%)  14/16 (88%)  7/13 (54%)   7/11 (64%)  |14/17 (82%)  19/21 (90%)  12/13 (92%)  2/2 (100%)   | 
|POLY-3 RATE (b)    |     10/13.61     14/16.00     7/11.78      7/10.38     |14/16.81     19/21.00     12/12.92     2/2.00       | 
|POLY-3 PERCENT (g) |     73.5%        87.5%        59.4%        67.5%       |83.3%        90.5%        92.9%        100.0%       | 
|TERMINAL (d)       |     9/11 (82%)   13/15 (87%)  6/10 (60%)   5/8 (63%)   |13/15 (87%)  10/12 (83%)  10/10 (100%) 1/1 (100%)   | 
|FIRST INCIDENCE    |     669          630          702          642         |705          586          641          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.446N     P=0.568      P=0.300N     P=0.541N    |P=0.160N     P=0.033 *    P=0.240      P=0.685      | 
|POLY 3             |     P=0.323N     P=0.309      P=0.371N     P=0.551N    |P=0.519      P=0.435      P=0.412      P=0.662      | 
|POLY 1.5           |     P=0.305N     P=0.287      P=0.344N     P=0.536N    |P=0.513      P=0.419      P=0.407      P=0.652      | 
|POLY 6             |     P=0.336N     P=0.348      P=0.390N     P=0.556N    |P=0.530      P=0.463      P=0.418      P=0.679      | 
|LOGISTIC REGRESSION|     P=0.432N     P=0.288      P=0.378N     P=0.628N    |P=0.517      P=0.454      P=0.316      P=0.456      | 
|COCH-ARM / FISHERS |     P=0.280N     P=0.261      P=0.293N     P=0.504N    |P=0.506      P=0.396      P=0.409      P=0.702      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   0/49 (0%)    4/50 (8%)    6/50 (12%)  |3/50 (6%)    0/50 (0%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     5/46.18      0/44.95      4/46.03      6/45.76     |3/47.55      0/46.36      1/47.03      1/45.40      | 
|POLY-3 PERCENT (g) |     10.8%        0.0%         8.7%         13.1%       |6.3%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |     4/35 (11%)   0/40 (0%)    2/40 (5%)    3/37 (8%)   |3/39 (8%)    0/36 (0%)    1/41 (2%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     669          ---          463          526         |731 (T)      ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.026N*    P=0.445N     P=0.517     |P=0.484N     P=0.135N     P=0.287N     P=0.305N     | 
|POLY 3             |     P=0.125      P=0.033N*    P=0.502N     P=0.494     |P=0.501N     P=0.123N     P=0.309N     P=0.322N     | 
|POLY 1.5           |     P=0.129      P=0.034N*    P=0.501N     P=0.496     |P=0.501N     P=0.122N     P=0.311N     P=0.320N     | 
|POLY 6             |     P=0.121      P=0.031N*    P=0.499N     P=0.495     |P=0.497N     P=0.126N     P=0.307N     P=0.322N     | 
|LOGISTIC REGRESSION|     P=0.129      P=0.035N*    P=0.495N     P=0.505     |P=0.484N     (e)          P=0.287N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.129      P=0.030N*    P=0.500N     P=0.500     |P=0.500N     P=0.121N     P=0.316N     P=0.316N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      0/45.18      1/44.81     |2/47.57      0/46.36      0/47.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |4.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/41 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          705         |725          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222      (e)          (e)          P=0.500     |P=0.307N     P=0.254N     P=0.229N     P=0.243N     | 
|POLY 3             |     P=0.226      (e)          (e)          P=0.495     |P=0.309N     P=0.243N     P=0.240N     P=0.248N     | 
|POLY 1.5           |     P=0.228      (e)          (e)          P=0.497     |P=0.310N     P=0.241N     P=0.241N     P=0.246N     | 
|POLY 6             |     P=0.223      (e)          (e)          P=0.494     |P=0.307N     P=0.246N     P=0.238N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.228      (e)          (e)          P=0.498     |P=0.308N     P=0.249N     P=0.234N     P=0.243N     | 
|COCH-ARM / FISHERS |     P=0.229      (e)          (e)          P=0.500     |P=0.311N     P=0.247N     P=0.253N     P=0.253N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/45.96      0/44.95      1/45.92      1/44.81     |2/47.57      0/46.36      0/47.03      1/45.89      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.2%        |4.2%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/41 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          463          705         |725          ---          ---          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      (e)          P=0.500      P=0.500     |P=0.695      P=0.254N     P=0.229N     P=0.513N     | 
|POLY 3             |     P=0.343      (e)          P=0.500      P=0.495     |P=0.698      P=0.243N     P=0.240N     P=0.513N     | 
|POLY 1.5           |     P=0.348      (e)          P=0.500      P=0.497     |P=0.696      P=0.241N     P=0.241N     P=0.511N     | 
|POLY 6             |     P=0.338      (e)          P=0.501      P=0.494     |P=0.702      P=0.246N     P=0.238N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.318      (e)          P=0.386      P=0.498     |P=0.656N     P=0.249N     P=0.234N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.350      (e)          P=0.500      P=0.500     |P=0.696      P=0.247N     P=0.253N     P=0.508N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  12/49 (24%)  12/49 (24%)  11/48 (23%)  | 
|POLY-3 RATE (b)    |                                                        |12/47.55     12/46.30     12/47.66     11/45.68     | 
|POLY-3 PERCENT (g) |                                                        |25.2%        25.9%        25.2%        24.1%        | 
|TERMINAL (d)       |                                                        |12/39 (31%)  10/36 (28%)  9/41 (22%)   9/39 (23%)   | 
|FIRST INCIDENCE    |                                                        |731 (T)      630          656          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.428N     P=0.507      P=0.538N     P=0.504N     | 
|POLY 3             |                                                        |P=0.490N     P=0.564      P=0.590N     P=0.544N     | 
|POLY 1.5           |                                                        |P=0.494N     P=0.566      P=0.583      P=0.548N     | 
|POLY 6             |                                                        |P=0.474N     P=0.565      P=0.571N     P=0.528N     | 
|LOGISTIC REGRESSION|                                                        |P=0.499N     P=0.538      P=0.588      P=0.557N     | 
|COCH-ARM / FISHERS |                                                        |P=0.490N     P=0.570      P=0.570      P=0.545N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      1/44.95      0/45.18      0/44.71     |1/46.74      0/46.36      2/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.1%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |731 (T)      ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.612N     P=0.527      (e)          (e)         |P=0.430N     P=0.516N     P=0.526      P=0.500N     | 
|POLY 3             |     P=0.606N     P=0.502      (e)          (e)         |P=0.444N     P=0.502N     P=0.509      P=0.507N     | 
|POLY 1.5           |     P=0.606N     P=0.501      (e)          (e)         |P=0.445N     P=0.499N     P=0.508      P=0.507N     | 
|POLY 6             |     P=0.605N     P=0.504      (e)          (e)         |P=0.439N     P=0.505N     P=0.511      P=0.507N     | 
|LOGISTIC REGRESSION|     (e)          P=0.527      (e)          (e)         |P=0.430N     (e)          P=0.526      (e)          | 
|COCH-ARM / FISHERS |     P=0.604N     P=0.505      (e)          (e)         |P=0.445N     P=0.495N     P=0.508      P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    1/48 (2%)    4/50 (8%)    1/48 (2%)   |16/48 (33%)  11/49 (22%)  16/47 (34%)  11/46 (24%)  | 
|POLY-3 RATE (b)    |     0/40.90      1/44.01      4/46.03      1/42.78     |16/46.36     11/45.80     16/45.68     11/43.79     | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         8.7%         2.3%        |34.5%        24.0%        35.0%        25.1%        | 
|TERMINAL (d)       |     0/34 (0%)    0/39 (0%)    2/40 (5%)    1/36 (3%)   |12/38 (32%)  11/36 (31%)  13/39 (33%)  9/38 (24%)   | 
|FIRST INCIDENCE    |     ---          712          564          729 (T)     |680          731 (T)      641          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602      P=0.520      P=0.073      P=0.511     |P=0.244N     P=0.234N     P=0.545N     P=0.200N     | 
|POLY 3             |     P=0.604      P=0.515      P=0.076      P=0.509     |P=0.307N     P=0.189N     P=0.566      P=0.229N     | 
|POLY 1.5           |     P=0.618      P=0.515      P=0.077      P=0.514     |P=0.313N     P=0.179N     P=0.562      P=0.227N     | 
|POLY 6             |     P=0.589      P=0.516      P=0.076      P=0.505     |P=0.288N     P=0.205N     P=0.573      P=0.224N     | 
|LOGISTIC REGRESSION|     P=0.639      P=0.517      P=0.114      P=0.511     |P=0.317N     P=0.199N     P=0.559      P=0.231N     | 
|COCH-ARM / FISHERS |     P=0.634      P=0.527      P=0.079      P=0.527     |P=0.310N     P=0.166N     P=0.557      P=0.218N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/45.96      1/45.45      1/45.60      0/44.71     |                                                    | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         2.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      663          606          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225N     P=0.472N     P=0.482N     P=0.226N    |                                                    | 
|POLY 3             |     P=0.219N     P=0.504N     P=0.503N     P=0.243N    |                                                    | 
|POLY 1.5           |     P=0.216N     P=0.507N     P=0.502N     P=0.241N    |                                                    | 
|POLY 6             |     P=0.223N     P=0.496N     P=0.500N     P=0.245N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.215N     P=0.505N     P=0.497N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.214N     P=0.500N     P=0.500N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.96      0/45.21      0/45.18      2/45.15     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.4%        |                                                    | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          600         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169      P=0.473N     P=0.473N     P=0.503     |                                                    | 
|POLY 3             |     P=0.174      P=0.503N     P=0.503N     P=0.494     |                                                    | 
|POLY 1.5           |     P=0.176      P=0.504N     P=0.502N     P=0.496     |                                                    | 
|POLY 6             |     P=0.172      P=0.500N     P=0.503N     P=0.494     |                                                    | 
|LOGISTIC REGRESSION|     P=0.175      (e)          (e)          P=0.506     |                                                    | 
|COCH-ARM / FISHERS |     P=0.175      P=0.500N     P=0.500N     P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/50 (4%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.96      3/46.09      2/45.95      2/44.71     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         6.5%         4.4%         4.5%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/40 (0%)    2/37 (5%)   |                                                    | 
|FIRST INCIDENCE    |     ---          568          596          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.483      P=0.125      P=0.225      P=0.251     |                                                    | 
|POLY 3             |     P=0.480      P=0.119      P=0.237      P=0.231     |                                                    | 
|POLY 1.5           |     P=0.486      P=0.117      P=0.237      P=0.234     |                                                    | 
|POLY 6             |     P=0.474      P=0.124      P=0.240      P=0.229     |                                                    | 
|LOGISTIC REGRESSION|     P=0.486      P=0.134      P=0.224      P=0.251     |                                                    | 
|COCH-ARM / FISHERS |     P=0.494      P=0.121      P=0.247      P=0.247     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.96      2/45.21      2/45.18      0/44.71     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         4.4%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    2/40 (5%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.349N     P=0.268      P=0.268      (e)         |                                                    | 
|POLY 3             |     P=0.355N     P=0.234      P=0.233      (e)         |                                                    | 
|POLY 1.5           |     P=0.351N     P=0.232      P=0.235      (e)         |                                                    | 
|POLY 6             |     P=0.358N     P=0.237      P=0.234      (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.268      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.247      P=0.247      (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    2/49 (4%)    1/49 (2%)    0/49 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/43.55      2/44.95      1/44.79      0/43.93     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    1/40 (3%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.369N     P=0.268      P=0.527      (e)         |                                                    | 
|POLY 3             |     P=0.370N     P=0.244      P=0.506      (e)         |                                                    | 
|POLY 1.5           |     P=0.367N     P=0.243      P=0.507      (e)         |                                                    | 
|POLY 6             |     P=0.373N     P=0.247      P=0.505      (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.527      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.361N     P=0.258      P=0.510      (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/44.96      1/45.45      0/45.18      0/44.71     |1/47.92      3/46.36      2/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.1%         6.5%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    3/36 (8%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          663          ---          ---         |624          731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.622N     P=0.495      (e)          (e)         |P=0.171N     P=0.280      P=0.517      P=0.517N     | 
|POLY 3             |     P=0.609N     P=0.502      (e)          (e)         |P=0.186N     P=0.294      P=0.501      P=0.511N     | 
|POLY 1.5           |     P=0.609N     P=0.500      (e)          (e)         |P=0.183N     P=0.299      P=0.500      P=0.509N     | 
|POLY 6             |     P=0.606N     P=0.507      (e)          (e)         |P=0.187N     P=0.287      P=0.502      P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.610N     P=0.516      (e)          (e)         |P=0.176N     P=0.322      P=0.477      P=0.366N     | 
|COCH-ARM / FISHERS |     P=0.607N     P=0.505      (e)          (e)         |P=0.177N     P=0.309      P=0.500      P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    1/50 (2%)    6/50 (12%)   5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/44.96      1/46.20      6/45.50      5/45.35     |0/47.55      0/46.36      0/48.03      1/45.44      | 
|POLY-3 PERCENT (g) |     8.9%         2.2%         13.2%        11.0%       |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     4/34 (12%)   0/40 (0%)    5/40 (13%)   2/37 (5%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      137          641          632         |---          ---          ---          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.267      P=0.145N     P=0.461      P=0.532     |P=0.234      (e)          (e)          P=0.505      | 
|POLY 3             |     P=0.265      P=0.170N     P=0.377      P=0.505     |P=0.222      (e)          (e)          P=0.491      | 
|POLY 1.5           |     P=0.270      P=0.173N     P=0.379      P=0.507     |P=0.223      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.260      P=0.165N     P=0.382      P=0.509     |P=0.224      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.272      P=0.118N     P=0.376      P=0.501     |P=0.221      (e)          (e)          P=0.491      | 
|COCH-ARM / FISHERS |     P=0.276      P=0.175N     P=0.383      P=0.513     |P=0.224      (e)          (e)          P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    2/48 (4%)    2/50 (4%)    2/50 (4%)   |4/49 (8%)    4/50 (8%)    2/50 (4%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     4/44.78      2/44.66      2/45.18      2/44.71     |4/47.39      4/46.97      2/48.03      3/45.19      | 
|POLY-3 PERCENT (g) |     8.9%         4.5%         4.4%         4.5%        |8.4%         8.5%         4.2%         6.6%         | 
|TERMINAL (d)       |     2/35 (6%)    1/40 (3%)    2/40 (5%)    2/37 (5%)   |1/39 (3%)    1/36 (3%)    2/42 (5%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     693          627          729 (T)      729 (T)     |624          643          731 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422N     P=0.307N     P=0.296N     P=0.326N    |P=0.460N     P=0.607      P=0.319N     P=0.510N     | 
|POLY 3             |     P=0.407N     P=0.338N     P=0.333N     P=0.338N    |P=0.487N     P=0.638      P=0.331N     P=0.526N     | 
|POLY 1.5           |     P=0.398N     P=0.343N     P=0.327N     P=0.330N    |P=0.485N     P=0.641N     P=0.330N     P=0.521N     | 
|POLY 6             |     P=0.420N     P=0.330N     P=0.338N     P=0.347N    |P=0.486N     P=0.630      P=0.334N     P=0.529N     | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.338N     P=0.331N     P=0.340N    |P=0.446N     P=0.546N     P=0.344N     P=0.477N     | 
|COCH-ARM / FISHERS |     P=0.391N     P=0.339N     P=0.319N     P=0.319N    |P=0.479N     P=0.631N     P=0.329N     P=0.512N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |3/49 (6%)    5/50 (10%)   1/50 (2%)    6/48 (13%)   | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      1/44.71     |3/47.69      5/47.53      1/48.11      6/45.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |6.3%         10.5%        2.1%         13.2%        | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    4/39 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |588          533          711          666          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          (e)          P=0.511     |P=0.198      P=0.339      P=0.298N     P=0.238      | 
|POLY 3             |     P=0.227      (e)          (e)          P=0.501     |P=0.171      P=0.355      P=0.302N     P=0.218      | 
|POLY 1.5           |     P=0.230      (e)          (e)          P=0.504     |P=0.174      P=0.361      P=0.301N     P=0.223      | 
|POLY 6             |     P=0.224      (e)          (e)          P=0.498     |P=0.170      P=0.347      P=0.305N     P=0.215      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.511     |P=0.250      P=0.589      P=0.333N     P=0.276      | 
|COCH-ARM / FISHERS |     P=0.232      (e)          (e)          P=0.510     |P=0.181      P=0.369      P=0.301N     P=0.233      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    3/49 (6%)    9/50 (18%)   9/50 (18%)  |2/49 (4%)    5/50 (10%)   2/50 (4%)    6/48 (13%)   | 
|POLY-3 RATE (b)    |     2/44.63      3/44.95      9/46.76      9/46.40     |2/47.51      5/47.32      2/48.38      6/45.81      | 
|POLY-3 PERCENT (g) |     4.5%         6.7%         19.3%        19.4%       |4.2%         10.6%        4.1%         13.1%        | 
|TERMINAL (d)       |     1/35 (3%)    3/40 (8%)    6/40 (15%)   6/37 (16%)  |0/39 (0%)    0/36 (0%)    0/42 (0%)    3/39 (8%)    | 
|FIRST INCIDENCE    |     711          729 (T)      531          526         |588          616          658          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025 *    P=0.555      P=0.041 *    P=0.035 *   |P=0.154      P=0.206      P=0.681N     P=0.132      | 
|POLY 3             |     P=0.028 *    P=0.503      P=0.030 *    P=0.029 *   |P=0.135      P=0.215      P=0.687N     P=0.122      | 
|POLY 1.5           |     P=0.029 *    P=0.501      P=0.030 *    P=0.030 *   |P=0.136      P=0.219      P=0.687N     P=0.123      | 
|POLY 6             |     P=0.027 *    P=0.508      P=0.031 *    P=0.029 *   |P=0.137      P=0.211      P=0.687N     P=0.122      | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.521      P=0.034 *    P=0.036 *   |P=0.210      P=0.364      P=0.666      P=0.182      | 
|COCH-ARM / FISHERS |     P=0.029 *    P=0.510      P=0.030 *    P=0.030 *   |P=0.139      P=0.226      P=0.684N     P=0.127      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |2/49 (4%)    0/50 (0%)    1/50 (2%)    4/48 (8%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.95      0/45.18      1/44.71     |2/47.51      0/46.36      1/48.30      4/45.57      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |4.2%         0.0%         2.1%         8.8%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    1/37 (3%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |588          ---          658          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          (e)          P=0.511     |P=0.062      P=0.252N     P=0.498N     P=0.324      | 
|POLY 3             |     P=0.227      (e)          (e)          P=0.501     |P=0.058      P=0.243N     P=0.494N     P=0.318      | 
|POLY 1.5           |     P=0.230      (e)          (e)          P=0.504     |P=0.057      P=0.238N     P=0.494N     P=0.321      | 
|POLY 6             |     P=0.224      (e)          (e)          P=0.498     |P=0.060      P=0.249N     P=0.495N     P=0.318      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.511     |P=0.105      P=0.073N     P=0.592N     P=0.438      | 
|COCH-ARM / FISHERS |     P=0.232      (e)          (e)          P=0.510     |P=0.058      P=0.242N     P=0.492N     P=0.329      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    5/49 (10%)   9/50 (18%)   7/50 (14%)  |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/44.63      5/44.95      9/46.76      7/45.78     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     4.5%         11.1%        19.3%        15.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    5/40 (13%)   6/40 (15%)   5/37 (14%)  |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     711          729 (T)      531          527         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172      P=0.271      P=0.041 *    P=0.092     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.187      P=0.219      P=0.030 *    P=0.085     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.194      P=0.217      P=0.030 *    P=0.087     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.181      P=0.223      P=0.031 *    P=0.083     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.199      P=0.238      P=0.034 *    P=0.095     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.197      P=0.226      P=0.030 *    P=0.090     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/49 (2%)    3/50 (6%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      1/44.95      3/45.18      3/45.33     |0/46.74      0/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         6.6%         6.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    3/40 (8%)    2/37 (5%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     711          729 (T)      729 (T)      527         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225      P=0.737N     P=0.348      P=0.316     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.234      P=0.759N     P=0.310      P=0.311     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.240      P=0.760N     P=0.314      P=0.315     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.227      P=0.757N     P=0.307      P=0.307     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.241      P=0.760N     P=0.311      P=0.332     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      P=0.747N     P=0.324      P=0.324     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/46 (2%)    1/48 (2%)    1/50 (2%)    1/48 (2%)   |2/49 (4%)    1/48 (2%)    1/50 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     1/42.93      1/44.71      1/45.49      1/43.78     |2/46.94      1/45.21      1/48.30      1/45.05      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.2%         2.3%        |4.3%         2.2%         2.1%         2.2%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |1/39 (3%)    0/36 (0%)    0/42 (0%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      611          642          711         |680          669          658          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.672      P=0.748N     P=0.751N     P=0.754N    |P=0.525N     P=0.520N     P=0.494N     P=0.505N     | 
|POLY 3             |     P=0.680      P=0.752N     P=0.748N     P=0.756N    |P=0.531N     P=0.513N     P=0.490N     P=0.514N     | 
|POLY 1.5           |     P=0.678N     P=0.754N     P=0.745N     P=0.754N    |P=0.530N     P=0.511N     P=0.491N     P=0.512N     | 
|POLY 6             |     P=0.674      P=0.748N     P=0.749N     P=0.758N    |P=0.530N     P=0.516N     P=0.488N     P=0.515N     | 
|LOGISTIC REGRESSION|     P=0.683N     P=0.744N     P=0.740N     P=0.760N    |P=0.478N     P=0.468N     P=0.518N     P=0.506N     | 
|COCH-ARM / FISHERS |     P=0.679N     P=0.742N     P=0.731N     P=0.742N    |P=0.527N     P=0.508N     P=0.492N     P=0.508N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    2/48 (4%)    1/50 (2%)    0/48 (0%)   |0/49 (0%)    0/48 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/42.93      2/44.92      1/45.28      0/43.70     |0/46.74      0/44.98      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/40 (0%)    0/37 (0%)   |0/39 (0%)    0/36 (0%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          568          702          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.376N     P=0.243      P=0.510      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.367N     P=0.247      P=0.511      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.365N     P=0.245      P=0.513      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.368N     P=0.252      P=0.509      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.368N     P=0.268      P=0.517      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.361N     P=0.258      P=0.521      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    1/49 (2%)    0/49 (0%)   |2/49 (4%)    1/50 (2%)    3/50 (6%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.31      1/44.18      0/43.71     |2/46.83      1/46.36      3/48.03      1/45.08      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.3%         2.2%         6.3%         2.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/39 (3%)    0/36 (0%)   |2/39 (5%)    1/36 (3%)    3/42 (7%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |731 (T)      731 (T)      731 (T)      722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.780N     (e)          P=0.522      (e)         |P=0.447N     P=0.528N     P=0.534      P=0.497N     | 
|POLY 3             |     P=0.775N     (e)          P=0.498      (e)         |P=0.472N     P=0.504N     P=0.511      P=0.513N     | 
|POLY 1.5           |     P=0.772N     (e)          P=0.501      (e)         |P=0.474N     P=0.499N     P=0.510      P=0.512N     | 
|POLY 6             |     P=0.779N     (e)          P=0.497      (e)         |P=0.467N     P=0.509N     P=0.513      P=0.512N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.522      (e)         |P=0.455N     P=0.528N     P=0.534      P=0.508N     | 
|COCH-ARM / FISHERS |     P=0.770N     (e)          P=0.505      (e)         |P=0.472N     P=0.492N     P=0.510      P=0.508N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   4/50 (8%)    15/50 (30%) |1/50 (2%)    2/50 (4%)    1/50 (2%)    7/49 (14%)   | 
|POLY-3 RATE (b)    |     3/45.96      5/46.45      4/45.18      15/45.67    |1/47.55      2/46.36      1/48.03      7/45.40      | 
|POLY-3 PERCENT (g) |     6.5%         10.8%        8.9%         32.8%       |2.1%         4.3%         2.1%         15.4%        | 
|TERMINAL (d)       |     3/35 (9%)    3/40 (8%)    4/40 (10%)   12/37 (32%) |1/39 (3%)    2/36 (6%)    1/42 (2%)    7/39 (18%)   | 
|FIRST INCIDENCE    |     729 (T)      137          729 (T)      560         |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.412      P=0.573      P=0.003 **  |P=0.004 **   P=0.472      P=0.745N     P=0.032 *    | 
|POLY 3             |     P<0.001 **   P=0.362      P=0.491      P<0.001 **  |P=0.003 **   P=0.491      P=0.758N     P=0.025 *    | 
|POLY 1.5           |     P<0.001 **   P=0.357      P=0.494      P<0.001 **  |P=0.003 **   P=0.495      P=0.759N     P=0.026 *    | 
|POLY 6             |     P<0.001 **   P=0.374      P=0.492      P<0.001 **  |P=0.003 **   P=0.487      P=0.757N     P=0.025 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.406      P=0.573      P=0.002 **  |P=0.004 **   P=0.472      P=0.745N     P=0.032 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.357      P=0.500      P=0.002 **  |P=0.004 **   P=0.500      P=0.753N     P=0.028 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/50 (48%)  15/50 (30%)  15/50 (30%)  16/50 (32%) |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     24/47.03     15/45.21     15/45.28     16/45.57    |1/47.55      1/46.36      0/48.03      0/45.40      | 
|POLY-3 PERCENT (g) |     51.0%        33.2%        33.1%        35.1%       |2.1%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     18/35 (51%)  15/40 (38%)  14/40 (35%)  13/37 (35%) |1/39 (3%)    1/36 (3%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     641          729 (T)      702          637         |731 (T)      731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265N     P=0.020N*    P=0.022N*    P=0.070N    |P=0.343N     P=0.744      P=0.485N     P=0.500N     | 
|POLY 3             |     P=0.240N     P=0.061N     P=0.059N     P=0.087N    |P=0.356N     P=0.755      P=0.498N     P=0.509N     | 
|POLY 1.5           |     P=0.232N     P=0.060N     P=0.054N     P=0.082N    |P=0.355N     P=0.757      P=0.499N     P=0.508N     | 
|POLY 6             |     P=0.248N     P=0.060N     P=0.065N     P=0.092N    |P=0.356N     P=0.752      P=0.496N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.282N     P=0.044N*    P=0.052N     P=0.093N    |P=0.343N     P=0.744      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.239N     P=0.050N     P=0.050N     P=0.076N    |P=0.352N     P=0.753N     P=0.500N     P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    1/50 (2%)    4/50 (8%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |                                                        |3/47.55      1/46.39      4/48.03      2/45.05      | 
|POLY-3 PERCENT (g) |                                                        |6.3%         2.2%         8.3%         4.4%         | 
|TERMINAL (d)       |                                                        |3/39 (8%)    0/36 (0%)    4/42 (10%)   2/39 (5%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      725          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.541N     P=0.333N     P=0.541      P=0.500N     | 
|POLY 3             |                                                        |P=0.573N     P=0.314N     P=0.506      P=0.525N     | 
|POLY 1.5           |                                                        |P=0.574N     P=0.311N     P=0.503      P=0.523N     | 
|POLY 6             |                                                        |P=0.566N     P=0.319N     P=0.510      P=0.522N     | 
|LOGISTIC REGRESSION|                                                        |P=0.544N     P=0.323N     P=0.541      P=0.500N     | 
|COCH-ARM / FISHERS |                                                        |P=0.573N     P=0.309N     P=0.500      P=0.520N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/47.55      1/46.36      2/48.44      2/45.68      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.2%         4.1%         4.4%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    1/36 (3%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          731 (T)      641          585          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.264      P=0.484      P=0.255      P=0.231      | 
|POLY 3             |                                                        |P=0.257      P=0.495      P=0.241      P=0.228      | 
|POLY 1.5           |                                                        |P=0.254      P=0.497      P=0.240      P=0.228      | 
|POLY 6             |                                                        |P=0.264      P=0.492      P=0.245      P=0.231      | 
|LOGISTIC REGRESSION|                                                        |P=0.341      P=0.484      P=0.204      P=0.315      | 
|COCH-ARM / FISHERS |                                                        |P=0.253      P=0.500      P=0.247      P=0.237      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/47.55      2/46.36      0/48.03      0/45.05      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    2/36 (6%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.385N     P=0.221      (e)          (e)          | 
|POLY 3             |                                                        |P=0.405N     P=0.232      (e)          (e)          | 
|POLY 1.5           |                                                        |P=0.403N     P=0.234      (e)          (e)          | 
|POLY 6             |                                                        |P=0.407N     P=0.229      (e)          (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.221      (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.399N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/09/02                           EXPERIMENT: 90004 TEST: 06                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |46/50 (92%)  48/50 (96%)  48/50 (96%)  45/48 (94%)  | 
|POLY-3 RATE (b)    |                                                        |46/49.31     48/48.95     48/50.00     45/47.16     | 
|POLY-3 PERCENT (g) |                                                        |93.3%        98.1%        96.0%        95.4%        | 
|TERMINAL (d)       |                                                        |38/39 (97%)  36/36 (100%) 40/42 (95%)  38/39 (97%)  | 
|FIRST INCIDENCE    |                                                        |588          586          600          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.286N     P=0.166      P=0.491N     P=0.525N     | 
|POLY 3             |                                                        |P=0.637N     P=0.225      P=0.436      P=0.495      | 
|POLY 1.5           |                                                        |P=0.614N     P=0.270      P=0.387      P=0.505      | 
|POLY 6             |                                                        |P=0.649      P=0.186      P=0.526      P=0.493      | 
|LOGISTIC REGRESSION|                                                        |P=0.475      P=0.131      P=0.359      P=0.396      | 
|COCH-ARM / FISHERS |                                                        |P=0.589N     P=0.339      P=0.339      P=0.523      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).