Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/12623

TDMS Study 90004-07 Pathology Tables

NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54

                                                          FINAL#2/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  57018-52-7

       Lock Date:  12/11/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           12           20           11                                     
    Natural Death                                      3            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           34           28           36                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    3 (6%)       1 (2%)                                
      Basophilic Focus                                39 (80%)     45 (90%)     43 (86%)     40 (80%)                               
      Clear Cell Focus                                12 (24%)     13 (26%)     11 (22%)     27 (54%)                               
      Eosinophilic Focus                               1 (2%)                                 1 (2%)                                
      Fatty Change                                                  1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       8 (16%)     10 (20%)      9 (18%)      7 (14%)                               
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)       2 (4%)                                
      Necrosis                                                      1 (2%)       1 (2%)       2 (4%)                                
      Thrombosis                                                                              1 (2%)                                
      Vacuolization Cytoplasmic                        3 (6%)       4 (8%)       3 (6%)                                             
      Bile Duct, Dilatation                            1 (2%)                                                                       
      Serosa, Hemorrhage                               1 (2%)                                                                       
   Mesentery                                          (17)         (23)         (10)         (17)                                   
      Necrosis                                        17 (100%)    21 (91%)      9 (90%)     17 (100%)                              
      Fat, Hemorrhage                                  1 (6%)       1 (4%)                                                          
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Erosion                                                                                 1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                                      4 (8%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Tongue                                             (2)                                    (1)                                    
      Epithelium, Hyperkeratosis                                                              1 (100%)                              
      Epithelium, Hyperplasia                          1 (50%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (1)                                                                           
      Peridontal Tissue, Inflammation                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                3 (6%)       1 (2%)                                             
      Atrium, Thrombosis                                            2 (4%)                                                          
      Epicardium, Inflammation, Chronic                                          1 (2%)                                             
      Myocardium, Degeneration                                                   1 (2%)                                             
      Myocardium, Necrosis                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Atrophy                                                       1 (2%)                                                          
      Degeneration, Cystic                             1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      2 (4%)                    2 (4%)       1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Vacuolization Cytoplasmic                       15 (31%)     10 (20%)      6 (12%)      5 (10%)                               
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       2 (4%)                                             
   Pituitary Gland                                    (49)         (50)         (50)         (49)                                   
      Angiectasis                                      4 (8%)       4 (8%)       1 (2%)       4 (8%)                                
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                      3 (6%)       6 (12%)      3 (6%)       3 (6%)                                
      Pars Intermedia, Vacuolization Cytoplasmic                                              1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              9 (18%)      8 (16%)      7 (14%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)       3 (6%)       1 (2%)       4 (8%)                                
      Hyperplasia                                      3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic                                         1 (2%)       2 (4%)       1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             6 (12%)      5 (10%)      3 (6%)       8 (16%)                               
      Hemorrhage                                                                 1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Decidual Reaction                                1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Endometrium, Hyperplasia                                                   1 (2%)       2 (4%)                                
      Endometrium, Ulcer                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (3)          (3)          (6)                                    
      Deep Cervical, Infiltration Cellular,                                                                                         
        Histiocyte                                                               1 (33%)                                            
      Deep Cervical, Inflammation, Chronic             1 (20%)                                                                      
   Lymph Node, Bronchial                              (9)          (4)          (10)         (5)                                    
      Angiectasis                                      1 (11%)                                1 (20%)                               
      Infiltration Cellular, Histiocyte                                          1 (10%)                                            
   Lymph Node, Mandibular                             (1)          (2)          (2)                                                 
      Ectasia                                                       1 (50%)      1 (50%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
   Lymph Node, Mediastinal                            (43)         (46)         (45)         (43)                                   
      Angiectasis                                      3 (7%)       1 (2%)       1 (2%)       2 (5%)                                
      Fibrosis                                                      1 (2%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)       2 (4%)       4 (9%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pigmentation                                     3 (7%)       1 (2%)                                                          
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)       2 (4%)                                                          
      Degeneration                                                  1 (2%)                                                          
      Fibrosis                                                                                2 (4%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                                      1 (2%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)         (50)                                   
      Galactocele                                                   7 (14%)      2 (4%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)       1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                        1 (2%)                                                          
      Maxilla, Necrosis                                1 (2%)                                                                       
      Metatarsal, Fracture                                                                    1 (2%)                                
      Tibia, Osteopetrosis                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression                                      5 (10%)      9 (18%)      8 (16%)      4 (8%)                                
      Hemorrhage                                       4 (8%)       3 (6%)       6 (12%)      2 (4%)                                
      Hydrocephalus                                                 1 (2%)                                                          
      Medulla, Gliosis, Focal                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        4 (8%)       2 (4%)       1 (2%)       2 (4%)                                
      Epiglottis, Metaplasia, Squamous                                           1 (2%)       2 (4%)                                
      Respiratory Epithelium, Epiglottis,                                                                                           
        Degeneration                                                             1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                       1 (2%)       2 (4%)                    1 (2%)                                
      Inflammation, Chronic                            9 (18%)      2 (4%)       7 (14%)      6 (12%)                               
      Metaplasia, Osseous                                                        1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 6 (12%)      4 (8%)       5 (10%)      4 (8%)                                
      Alveolus, Infiltration Cellular, Histiocyte     15 (30%)      9 (18%)     13 (26%)     20 (40%)                               
      Alveolus, Proteinosis                            4 (8%)                    3 (6%)       2 (4%)                                
      Bronchiole, Hyperplasia                          1 (2%)       1 (2%)                                                          
      Interstitium, Fibrosis                           4 (8%)       1 (2%)       4 (8%)       2 (4%)                                
      Mediastinum, Inflammation, Granulomatous                                   1 (2%)                                             
   Nose                                               (49)         (49)         (50)         (50)                                   
      Foreign Body                                     2 (4%)       2 (4%)       2 (4%)                                             
      Inflammation, Suppurative                        4 (8%)       2 (4%)       5 (10%)                                            
      Glands, Dilatation                                                                      4 (8%)                                
      Goblet Cell, Hyperplasia                                                                3 (6%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
      Olfactory Epithelium, Degeneration, Hyaline     10 (20%)     22 (45%)     48 (96%)     50 (100%)                              
      Respiratory Epithelium, Hyperplasia              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Pleura                                             (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                           15 (30%)     10 (20%)     11 (22%)     17 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (50)                                   
      Atrophy                                                                    2 (4%)                                             
      Phthisis Bulbi                                   1 (2%)                    1 (2%)                                             
      Anterior Chamber, Sclera, Inflammation,                                                                                       
        Suppurative                                                              1 (2%)                                             
      Cornea, Edema                                                                           1 (2%)                                
      Cornea, Inflammation, Chronic                                              1 (2%)       1 (2%)                                
      Cornea, Mineralization                                                                 10 (20%)                               
      Cornea, Necrosis                                                                        1 (2%)                                
      Lens, Cataract                                   1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Lens, Mineralization                                          1 (2%)                                                          
      Sclera, Inflammation, Suppurative                1 (2%)                                                                       
   Zymbal's Gland                                     (42)         (44)         (43)         (46)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                     2 (4%)                                                          
      Nephropathy, Chronic                            45 (92%)     45 (90%)     45 (90%)     49 (98%)                               
      Cortex, Infarct                                                                         1 (2%)                                
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                        1 (2%)       2 (4%)                    1 (2%)                                
      Cortex, Renal Tubule, Hyperplasia                                          1 (2%)       1 (2%)                                
      Pelvis, Mineralization                          13 (27%)      5 (10%)      7 (14%)      3 (6%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                  4 (8%)                                                          
      Renal Tubule, Mineralization                                               2 (4%)                                             
   Urethra                                                                                   (1)                                    
      Transitional Epithelium, Hyperplasia                                                    1 (100%)                              
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)                                                          
      Transitional Epithelium, Mineralization                                    1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           15           26           22                                     
    Natural Death                                      3            6            8            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           29           16           22                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (48)         (47)         (48)                                   
      Diverticulum                                     1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (47)         (47)         (45)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (47)         (47)         (47)                                   
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (47)         (47)         (42)         (46)                                   
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Ileum                             (47)         (47)         (43)         (45)                                   
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Liver                                              (50)         (50)         (49)         (50)                                   
      Basophilic Focus                                 6 (12%)     18 (36%)     15 (31%)     17 (34%)                               
      Clear Cell Focus                                 8 (16%)     11 (22%)     11 (22%)      9 (18%)                               
      Degeneration, Cystic                             1 (2%)                    1 (2%)       3 (6%)                                
      Eosinophilic Focus                                            1 (2%)       1 (2%)       2 (4%)                                
      Fatty Change                                     3 (6%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       1 (2%)       6 (12%)     11 (22%)      5 (10%)                               
      Necrosis                                                                   3 (6%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                        3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Dilatation                                                      1 (2%)                                             
      Bile Duct, Hyperplasia                                                     1 (2%)       1 (2%)                                
      Hepatocyte, Regeneration                                                   1 (2%)                                             
   Mesentery                                          (13)         (9)          (10)         (7)                                    
      Necrosis                                        13 (100%)     9 (100%)    10 (100%)     5 (71%)                               
      Thrombosis                                                                              1 (14%)                               
      Fat, Hemorrhage                                               1 (11%)                                                         
   Oral Mucosa                                                     (1)                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         1 (100%)                                                        
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Acinus, Atrophy                                               1 (2%)       1 (2%)                                             
      Artery, Inflammation                                                                    1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            2 (4%)       1 (2%)       2 (4%)       4 (8%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Ulcer                                            3 (6%)                    3 (6%)       4 (8%)                                
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                                                    3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Tongue                                             (2)                       (3)          (1)                                    
      Epithelium, Hyperplasia                          2 (100%)                  3 (100%)     1 (100%)                              
   Tooth                                              (1)          (2)                       (1)                                    
      Malformation                                                  1 (50%)                                                         
      Peridontal Tissue, Inflammation                  1 (100%)     1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (49)         (50)                                   
      Pulmonary Artery, Degeneration, Mucoid                                     1 (2%)                                             
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   7 (14%)      6 (12%)      4 (8%)       7 (14%)                               
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                    1 (2%)                                             
      Myocardium, Fibrosis                                          1 (2%)                                                          
      Myocardium, Necrosis                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                   1 (2%)                    3 (6%)                                
      Mineralization                                                             1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                        6 (12%)     14 (28%)      6 (12%)      9 (18%)                               
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      6 (12%)      4 (8%)      11 (22%)      9 (18%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Thrombosis                                                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (49)         (48)         (49)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Angiectasis                                      1 (2%)       3 (6%)       1 (2%)                                             
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                      5 (10%)      2 (4%)       4 (8%)       2 (4%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      C-Cell, Hyperplasia                              8 (16%)      4 (8%)       7 (14%)      7 (14%)                               
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                                                        (1)                                                 
      Necrosis                                                                   1 (100%)                                           
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)       3 (6%)       3 (6%)                                             
      Inflammation, Suppurative                        4 (8%)                    4 (8%)                                             
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Suppurative                       31 (62%)     24 (48%)     27 (55%)     27 (54%)                               
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Testes                                             (50)         (50)         (49)         (50)                                   
      Bilateral, Interstitial Cell, Hyperplasia                                  1 (2%)       1 (2%)                                
      Germinal Epithelium, Atrophy                    20 (40%)     19 (38%)     18 (37%)     20 (40%)                               
      Interstitial Cell, Hyperplasia                   4 (8%)       3 (6%)       7 (14%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (12)         (7)          (15)         (6)                                    
      Deep Cervical, Ectasia                                        1 (14%)                                                         
      Deep Cervical, Hyperplasia, Lymphoid             1 (8%)                                                                       
      Deep Cervical, Inflammation                                   1 (14%)                                                         
      Deep Cervical, Inflammation, Suppurative                                                1 (17%)                               
      Pancreatic, Ectasia                              1 (8%)                                                                       
      Pancreatic, Hemorrhage                                                     1 (7%)                                             
      Pancreatic, Pigmentation                                      1 (14%)                                                         
   Lymph Node, Bronchial                              (24)         (7)          (9)          (21)                                   
      Hemorrhage                                                                 1 (11%)                                            
      Hyperplasia, Lymphoid                                                                   2 (10%)                               
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Ectasia                                                       1 (2%)                                                          
      Fibrosis                                                                                1 (2%)                                
   Lymph Node, Mediastinal                            (38)         (41)         (46)         (45)                                   
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (3%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Accessory Spleen                                 2 (4%)       3 (6%)       4 (8%)       1 (2%)                                
      Fibrosis                                         5 (10%)      1 (2%)       7 (14%)      4 (8%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       3 (6%)                                
      Necrosis                                         1 (2%)       2 (4%)       5 (10%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Galactocele                                      3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
      Epithelium, Cyst, Squamous                                                              1 (2%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                        3 (6%)       5 (10%)      3 (6%)       1 (2%)                                
      Hyperkeratosis                                   3 (6%)       1 (2%)       6 (12%)      1 (2%)                                
      Inflammation, Granulomatous                                                             2 (4%)                                
      Ulcer                                            1 (2%)                                 2 (4%)                                
      Prepuce, Ulcer                                                             1 (2%)                                             
      Sebaceous Gland, Hyperplasia, Squamous           1 (2%)                                                                       
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Cranium, Hemorrhage                                                                     1 (2%)                                
   Skeletal Muscle                                                              (2)          (3)                                    
      Mineralization                                                                          1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Compression                                      7 (14%)      4 (8%)       5 (10%)      3 (6%)                                
      Gliosis                                                                    1 (2%)                                             
      Hemorrhage                                       4 (8%)       4 (8%)       4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (48)         (50)                                   
      Foreign Body                                     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 3 (6%)                                
      Inflammation, Suppurative                                     2 (4%)       1 (2%)                                             
      Epiglottis, Hyperplasia                                       1 (2%)       1 (2%)       1 (2%)                                
      Epiglottis, Metaplasia, Squamous                                           1 (2%)                                             
   Lung                                               (50)         (50)         (49)         (50)                                   
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            5 (10%)      2 (4%)       5 (10%)      4 (8%)                                
      Inflammation, Suppurative                                                  1 (2%)       2 (4%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 6 (12%)      2 (4%)       5 (10%)      6 (12%)                               
      Alveolar Epithelium, Metaplasia, Squamous        1 (2%)                                 4 (8%)                                
      Alveolus, Foreign Body                                                                  2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte     11 (22%)      3 (6%)       8 (16%)      8 (16%)                               
      Alveolus, Proteinosis                                         1 (2%)                                                          
      Artery, Mineralization                                                     1 (2%)                                             
      Artery, Thrombosis                                                         1 (2%)                                             
      Interstitium, Fibrosis                           5 (10%)      1 (2%)       4 (8%)       6 (12%)                               
   Nose                                               (50)         (49)         (49)         (50)                                   
      Foreign Body                                     6 (12%)      6 (12%)      4 (8%)       3 (6%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                                                                   4 (8%)                                
      Inflammation, Suppurative                        6 (12%)     10 (20%)     11 (22%)      4 (8%)                                
      Glands, Dilatation                               1 (2%)       2 (4%)       7 (14%)     15 (30%)                               
      Goblet Cell, Hyperplasia                         1 (2%)       1 (2%)       2 (4%)      15 (30%)                               
      Nasolacrimal Duct, Inflammation, Suppurative                  1 (2%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Degeneration, Hyaline                  25 (51%)     45 (92%)     50 (100%)                              
      Olfactory Epithelium, Hyperplasia, Basal Cell                                           1 (2%)                                
      Respiratory Epithelium, Hyperplasia              2 (4%)       2 (4%)       4 (8%)       3 (6%)                                
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Pleura                                             (49)         (50)         (49)         (50)                                   
      Inflammation, Chronic                            6 (12%)      2 (4%)       3 (6%)       7 (14%)                               
      Mesothelium, Hyperplasia                                                                2 (4%)                                
   Trachea                                            (50)         (49)         (49)         (50)                                   
      Glands, Cyst                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Cyst                                                          1 (100%)                                                        
   Eye                                                (50)         (49)         (49)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Anterior Chamber, Inflammation, Suppurative                                1 (2%)                                             
      Anterior Chamber, Cornea, Inflammation                                                  1 (2%)                                
      Anterior Chamber, Cornea, Inflammation,                                                                                       
        Suppurative                                                                           1 (2%)                                
      Cornea, Inflammation, Suppurative                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Infarct                                                       1 (2%)                                                          
      Nephropathy, Chronic                            46 (92%)     50 (100%)    49 (100%)    50 (100%)                              
      Pigmentation                                                               1 (2%)                                             
      Cortex, Infarct                                  4 (8%)                                 2 (4%)                                
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                        1 (2%)       2 (4%)       9 (18%)     17 (34%)                               
      Cortex, Renal Tubule, Hyperplasia                             3 (6%)       7 (14%)     19 (38%)                               
      Cortex, Renal Tubule, Necrosis                                             1 (2%)                                             
      Papilla, Mineralization                                       8 (16%)     28 (57%)     41 (82%)                               
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Inflammation, Suppurative                                          1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia     2 (4%)       1 (2%)       6 (12%)     15 (30%)                               
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Renal Tubule, Pigmentation                       1 (2%)                    2 (4%)                                             
   Urethra                                            (1)                       (1)          (2)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 90004-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 03/04/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:24:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                                                               1 (50%)                               
      Transitional Epithelium, Hyperplasia             1 (100%)                  1 (100%)     2 (100%)                              
   Urinary Bladder                                    (50)         (49)         (49)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             3 (6%)       1 (2%)       3 (6%)       6 (12%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------