National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13000

TDMS Study 90004-07 Pathology Tables

NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36

                                                          FINAL#1/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  57018-52-7

       Lock Date:  12/11/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           12           20           11                                     
    Natural Death                                      3            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           34           28           36                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)                                 2 (4%)                                
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
   Mesentery                                          (17)         (23)         (10)         (17)                                   
      Carcinoma, Metastatic, Ovary                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)       2 (4%)       1 (2%)       4 (8%)                                
      Carcinoma                                                     2 (4%)                    1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)       1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)       2 (4%)                                
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (50)         (49)                                   
      Adenoma                                         30 (61%)     36 (72%)     32 (64%)     22 (45%)                               
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  8 (16%)      2 (4%)       3 (6%)       4 (8%)                                
      C-Cell, Carcinoma                                2 (4%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)       2 (4%)       1 (2%)                                             
      Sarcoma, Metastatic, Vagina                      1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cystadenocarcinoma                                            1 (2%)       1 (2%)                                             
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    5 (10%)      7 (14%)     11 (22%)      6 (12%)                               
      Sarcoma Stromal                                                            1 (2%)                                             
      Bilateral, Polyp Stromal                                                   1 (2%)                                             
      Endometrium, Adenoma                                          1 (2%)                                                          
   Vagina                                             (1)                                                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (3)          (3)          (6)                                    
   Lymph Node, Bronchial                              (9)          (4)          (10)         (5)                                    
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (20%)                               
      Squamous Cell Carcinoma, Metastatic, Lung                                  1 (10%)                                            
   Lymph Node, Mandibular                             (1)          (2)          (2)                                                 
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Lymph Node, Mediastinal                            (43)         (46)         (45)         (43)                                   
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Lung                                  2 (4%)                                             
   Spleen                                             (49)         (50)         (50)         (50)                                   
   Thymus                                             (45)         (50)         (50)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)         (50)                                   
      Adenoma                                                       2 (4%)                                                          
      Carcinoma                                        4 (8%)       4 (8%)       1 (2%)       1 (2%)                                
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                    18 (37%)     21 (42%)     17 (34%)     20 (40%)                               
      Fibroadenoma, Multiple                           7 (14%)      8 (16%)      4 (8%)       9 (18%)                               
      Sarcoma, Metastatic, Vagina                      1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Eyelid, Neural Crest Tumor                                                 1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Liposarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Vagina                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (2)                                                 
      Fibrous Histiocytoma, Metastatic, Skin           1 (100%)                                                                     
      Squamous Cell Carcinoma, Metastatic, Lung                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Pineal Gland, Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
      Sarcoma, Metastatic, Vagina                      1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    2 (4%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Alveolus, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Lung                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (42)         (44)         (43)         (46)                                   
      Carcinoma                                        2 (5%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cortex, Renal Tubule, Adenoma                                                           1 (2%)                                
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            24 (48%)     24 (48%)     28 (56%)     20 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          50          45                                       
     Total Primary Neoplasms                          117         116         109          97                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          45          42          41                                       
     Total Benign Neoplasms                            75          82          71          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          27          32          23                                       
     Total Malignant Neoplasms                         42          34          37          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           3           1                                       
     Total Metastatic Neoplasm                          8           1           6           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           15           26           22                                     
    Natural Death                                      3            6            8            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           29           16           22                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Intestine Large, Colon                             (49)         (48)         (46)         (48)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (47)         (47)         (45)                                   
   Intestine Small, Ileum                             (47)         (47)         (43)         (45)                                   
   Liver                                              (50)         (50)         (49)         (50)                                   
      Cholangiocarcinoma                                                                      1 (2%)                                
      Hepatocellular Adenoma                           3 (6%)                    2 (4%)       6 (12%)                               
      Histiocytic Sarcoma, Metastatic, Skin                         1 (2%)                                                          
   Mesentery                                          (13)         (9)          (10)         (7)                                    
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Muscularis, Lipoma                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (49)         (50)                                   
      Aorta, Pulmonary Artery, Sarcoma, Metastatic,                                                                                 
           Heart                                                                              1 (2%)                                
   Heart                                              (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Lung                                                             1 (2%)                                
      Pericardium, Sarcoma                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Malignant                       2 (4%)                                 2 (4%)                                
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         10 (20%)      8 (16%)      8 (16%)      6 (12%)                               
      Bilateral, Pheochromocytoma Benign               2 (4%)                    3 (6%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          4 (8%)       4 (8%)       5 (10%)                                            
      Carcinoma                                                                  1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (49)         (48)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    2 (4%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Adenoma                                         35 (70%)     27 (54%)     26 (53%)     32 (64%)                               
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      C-Cell, Adenoma                                  3 (6%)       3 (6%)       3 (6%)       5 (10%)                               
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       3 (6%)       3 (6%)                                
      Follicular Cell, Adenoma                                      1 (2%)                    1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)          (2)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Prostate                                           (50)         (50)         (49)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
   Testes                                             (50)         (50)         (49)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           29 (58%)     31 (62%)     30 (61%)     32 (64%)                               
      Interstitial Cell, Adenoma                      12 (24%)     14 (28%)     10 (20%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
   Lymph Node                                         (12)         (7)          (15)         (6)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (14%)                                                         
   Lymph Node, Bronchial                              (24)         (7)          (9)          (21)                                   
      Carcinoma, Metastatic, Lung                                                             1 (5%)                                
      Histiocytic Sarcoma, Metastatic, Skin                         1 (14%)                                                         
   Lymph Node, Mandibular                             (1)          (3)          (3)          (1)                                    
      Carcinoma, Metastatic, Zymbal's Gland                         1 (33%)                                                         
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
   Lymph Node, Mediastinal                            (38)         (41)         (46)         (45)                                   
      Carcinoma, Metastatic, Lung                                                             1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skin                         1 (2%)                                                          
      Sarcoma, Metastatic, Heart                                                              1 (2%)                                
   Spleen                                             (50)         (50)         (49)         (50)                                   
   Thymus                                             (47)         (46)         (46)         (47)                                   
      Sarcoma, Metastatic, Heart                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Carcinoma                                                     2 (4%)       2 (4%)       1 (2%)                                
      Fibroadenoma                                     2 (4%)       2 (4%)       3 (6%)       3 (6%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                    3 (6%)                                
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Keratoacanthoma                                  1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       1 (2%)                                
      Pinna, Neural Crest Tumor                                     1 (2%)                                                          
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       4 (8%)       2 (4%)       4 (8%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
      Subcutaneous Tissue, Schwannoma Benign                                                  1 (2%)                                
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                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Mandible, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                                     1 (2%)                                                          
      Mandible, Osteosarcoma                           1 (2%)                                                                       
      Vertebra, Chordoma                                                         1 (2%)                                             
   Skeletal Muscle                                                              (2)          (3)                                    
      Carcinoma, Metastatic, Thyroid Gland                                       1 (50%)                                            
      Sarcoma, Metastatic, Skin                                                               1 (33%)                               
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Astrocytoma Benign                                                                      1 (2%)                                
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Skin                         1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma, Metastatic, Heart                                                              1 (2%)                                
   Pleura                                             (49)         (50)         (49)         (50)                                   
      Sarcoma, Metastatic, Heart                                                              1 (2%)                                
   Trachea                                            (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
   Zymbal's Gland                                     (44)         (41)         (39)         (46)                                   
      Carcinoma                                        1 (2%)       2 (5%)                    2 (4%)                                
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                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Lipoma                                                        1 (2%)                                                          
      Sarcoma, Metastatic, Heart                                                              1 (2%)                                
      Stromal Nephroma                                                                        1 (2%)                                
      Cortex, Renal Tubule, Adenoma                    1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Cortex, Renal Tubule, Adenoma, Multiple                                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (49)         (49)         (50)                                   
      Transitional Epithelium, Carcinoma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            33 (66%)     31 (62%)     35 (70%)     27 (54%)                               
      Mesothelioma Malignant                           2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 90004-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                PROPYLENE GLYCOL MONO-T-BUTYL ETHER                            Date: 11/14/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:44:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      75 PPM       300 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49          50                                       
     Total Primary Neoplasms                          154         143         145         162                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          50          48          49                                       
     Total Benign Neoplasms                           110         100          98         109                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          34          40          40                                       
     Total Malignant Neoplasms                         44          42          47          53                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           2           9                                       
     Total Metastatic Neoplasm                          1          10           2          18                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.