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TDMS Study 90004-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 03/04/03       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:25:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
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                                                            FINAL#2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 03/04/03       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:25:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF           PROPYLENE GLYCOL MONO-T-BUTYL ET                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Eye: Anterior Chamber, Cornea          Inflammation                                                                                 
Kidney                                 Nephropathy Chronic                                                                          
Kidney: Cortex                         Infarct                                                                                      
Kidney: Cortex, Renal Tubule           Accumulation, Hyaline Droplet                                                                
                                       Hyperplasia                                                                                  
Kidney: Papilla                        Mineralization                                                                               
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Hyperplasia                                                                                  
Larynx                                 Inflammation Chronic                                                                         
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Fatty Change                                                                                 
                                       Hepatodiaphragmatic Nodule                                                                   
Lung: Alveolar Epithelium              Metaplasia                                                                                   
Lung: Alveolus                         Foreign Body                                                                                 
                                       Infiltration Cellular Histiocyte                                                             
Lymph Node, Bronchial                  Hyperplasia Lymphoid                                                                         
Mesentery                              Necrosis                                                                                     
Nose                                   Inflammation Chronic                                                                         
Nose: Glands                           Dilatation                                                                                   
Nose: Goblet Cell                      Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Pleura: Mesothelium                    Hyperplasia                                                                                  
Preputial Gland                        Inflammation                                                                                 
Skin                                   Inflammation Granulomatous                                                                   
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Vacuolization Cytoplasmic                                                                    
Eye: Cornea                            Mineralization                                                                               
Kidney: Pelvis                         Mineralization                                                                               
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Lymph Node, Mediastinal                Pigmentation                                                                                 
Mammary Gland                          Galactocele                                                                                  
Nose                                   Inflammation                                                                                 
Nose: Glands                           Dilatation                                                                                   
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 03/04/03       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:25:28       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
Nose: Goblet Cell                      Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Spleen                                 Fibrosis                                                                                     
                                       Necrosis                                                                                     
===============================================================                                                                     
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |2/49 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/43.38      0/36.82      3/40.72     |2/42.54      0/46.42      2/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         7.4%        |4.7%         0.0%         4.8%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    3/22 (14%)  |2/33 (6%)    0/34 (0%)    2/28 (7%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |730 (T)      ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.514      (e)          P=0.086     |P=0.567N     P=0.232N     P=0.635      P=0.470N     | 
|POLY 3             |     P=0.039 *    P=0.508      (e)          P=0.113     |P=0.605N     P=0.218N     P=0.690      P=0.479N     | 
|POLY 1.5           |     P=0.040 *    P=0.505      (e)          P=0.117     |P=0.604N     P=0.222N     P=0.689N     P=0.482N     | 
|POLY 6             |     P=0.036 *    P=0.510      (e)          P=0.107     |P=0.604N     P=0.216N     P=0.674      P=0.476N     | 
|LOGISTIC REGRESSION|     (e)          P=0.514      (e)          P=0.086     |P=0.567N     (e)          P=0.635      P=0.470N     | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.500      (e)          P=0.121     |P=0.601N     P=0.242N     P=0.684N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.019 *    (e)          (e)          (e)         |P=0.386N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   14/50 (28%)  6/49 (12%)   9/50 (18%)  |15/49 (31%)  10/50 (20%)  6/50 (12%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     6/42.39      14/44.05     6/37.49      9/41.11     |15/43.81     10/46.63     6/42.61      5/45.42      | 
|POLY-3 PERCENT (g) |     14.2%        31.8%        16.0%        21.9%       |34.2%        21.4%        14.1%        11.0%        | 
|TERMINAL (d)       |     3/27 (11%)   9/29 (31%)   3/16 (19%)   6/22 (27%)  |12/33 (36%)  7/34 (21%)   2/28 (7%)    4/36 (11%)   | 
|FIRST INCIDENCE    |     625          642          611          662         |380          684          646          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413      P=0.069      P=0.318      P=0.187     |P=0.018N*    P=0.154N     P=0.061N     P=0.008N**   | 
|POLY 3             |     P=0.567      P=0.042 *    P=0.533      P=0.261     |P=0.018N*    P=0.129N     P=0.024N*    P=0.007N**   | 
|POLY 1.5           |     P=0.559N     P=0.041 *    P=0.570      P=0.276     |P=0.019N*    P=0.136N     P=0.020N*    P=0.007N**   | 
|POLY 6             |     P=0.531      P=0.044 *    P=0.473      P=0.234     |P=0.017N*    P=0.125N     P=0.030N*    P=0.007N**   | 
|LOGISTIC REGRESSION|     P=0.511      P=0.049 *    P=0.492      P=0.234     |P=0.020N*    P=0.128N     P=0.023N*    P=0.009N**   | 
|COCH-ARM / FISHERS |     P=0.547N     P=0.039 *    P=0.606      P=0.288     |P=0.022N*    P=0.163N     P=0.021N*    P=0.010N*    | 
|ORDER RESTRICTED   |     P=0.218      (e)          (e)          (e)         |P=0.003N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    11/49 (22%)  9/50 (18%)  |1/49 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/42.59      4/43.66      11/37.99     9/41.56     |1/42.54      1/46.42      2/42.14      0/45.19      | 
|POLY-3 PERCENT (g) |     14.1%        9.2%         29.0%        21.7%       |2.4%         2.2%         4.8%         0.0%         | 
|TERMINAL (d)       |     2/27 (7%)    2/29 (7%)    6/16 (38%)   5/22 (23%)  |1/33 (3%)    1/34 (3%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     642          689          634          648         |730 (T)      730 (T)      698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114      P=0.325N     P=0.029 *    P=0.205     |P=0.299N     P=0.755N     P=0.449      P=0.483N     | 
|POLY 3             |     P=0.157      P=0.353N     P=0.084      P=0.266     |P=0.311N     P=0.741N     P=0.497      P=0.488N     | 
|POLY 1.5           |     P=0.172      P=0.357N     P=0.105      P=0.278     |P=0.312N     P=0.745N     P=0.506      P=0.490N     | 
|POLY 6             |     P=0.133      P=0.351N     P=0.057      P=0.243     |P=0.309N     P=0.739N     P=0.482      P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.159      P=0.349N     P=0.068      P=0.263     |P=0.307N     P=0.755N     P=0.472      (e)          | 
|COCH-ARM / FISHERS |     P=0.190      P=0.370N     P=0.133      P=0.288     |P=0.315N     P=0.747N     P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.073      (e)          (e)          (e)         |P=0.271N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/50 (8%)    5/49 (10%)   3/50 (6%)   |5/49 (10%)   9/50 (18%)   8/50 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     7/43.43      4/44.37      5/37.69      3/41.41     |5/43.47      9/48.13      8/44.67      4/46.08      | 
|POLY-3 PERCENT (g) |     16.1%        9.0%         13.3%        7.3%        |11.5%        18.7%        17.9%        8.7%         | 
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    2/16 (13%)   1/22 (5%)   |3/33 (9%)    2/34 (6%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     465          509          605          631         |558          410          528          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.275N     P=0.238N     P=0.612      P=0.213N    |P=0.190N     P=0.253      P=0.242      P=0.461N     | 
|POLY 3             |     P=0.228N     P=0.247N     P=0.481N     P=0.175N    |P=0.184N     P=0.254      P=0.292      P=0.464N     | 
|POLY 1.5           |     P=0.218N     P=0.251N     P=0.439N     P=0.166N    |P=0.187N     P=0.241      P=0.299      P=0.469N     | 
|POLY 6             |     P=0.249N     P=0.245N     P=0.546N     P=0.193N    |P=0.180N     P=0.263      P=0.282      P=0.458N     | 
|LOGISTIC REGRESSION|     P=0.199N     P=0.297N     P=0.396N     P=0.156N    |P=0.210N     P=0.151      P=0.270      P=0.509N     | 
|COCH-ARM / FISHERS |     P=0.205N     P=0.262N     P=0.394N     P=0.159N    |P=0.194N     P=0.205      P=0.290      P=0.487N     | 
|ORDER RESTRICTED   |     P=0.150N     (e)          (e)          (e)         |P=0.252N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    4/49 (8%)    2/50 (4%)   |4/49 (8%)    3/50 (6%)    6/50 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/44.04      4/44.11      4/38.32      2/41.85     |4/44.43      3/46.79      6/44.66      2/46.53      | 
|POLY-3 PERCENT (g) |     9.1%         9.1%         10.4%        4.8%        |9.0%         6.4%         13.4%        4.3%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    0/22 (0%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     296          509          431          254         |284          683          507          283          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.301N     P=0.608N     P=0.533      P=0.363N    |P=0.271N     P=0.475N     P=0.353      P=0.321N     | 
|POLY 3             |     P=0.270N     P=0.643N     P=0.565      P=0.360N    |P=0.268N     P=0.472N     P=0.372      P=0.316N     | 
|POLY 1.5           |     P=0.260N     P=0.643N     P=0.596      P=0.349N    |P=0.270N     P=0.476N     P=0.381      P=0.319N     | 
|POLY 6             |     P=0.290N     P=0.641N     P=0.518      P=0.380N    |P=0.266N     P=0.467N     P=0.360      P=0.313N     | 
|LOGISTIC REGRESSION|     P=0.206N     P=0.507      P=0.598N     P=0.374N    |P=0.318N     P=0.643      P=0.267      P=0.518N     | 
|COCH-ARM / FISHERS |     P=0.250N     P=0.643N     P=0.631      P=0.339N    |P=0.276N     P=0.489N     P=0.383      P=0.329N     | 
|ORDER RESTRICTED   |     P=0.338N     (e)          (e)          (e)         |P=0.287N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |2/42.90      3/46.42      1/42.02      4/45.19      | 
|POLY-3 PERCENT (g) |                                                        |4.7%         6.5%         2.4%         8.9%         | 
|TERMINAL (d)       |                                                        |1/33 (3%)    3/34 (9%)    1/28 (4%)    4/36 (11%)   | 
|FIRST INCIDENCE    |                                                        |684          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.311      P=0.513      P=0.554N     P=0.375      | 
|POLY 3             |                                                        |P=0.276      P=0.536      P=0.507N     P=0.361      | 
|POLY 1.5           |                                                        |P=0.272      P=0.527      P=0.499N     P=0.356      | 
|POLY 6             |                                                        |P=0.280      P=0.540      P=0.523N     P=0.364      | 
|LOGISTIC REGRESSION|                                                        |P=0.291      P=0.543      P=0.519N     P=0.369      | 
|COCH-ARM / FISHERS |                                                        |P=0.262      P=0.500      P=0.500N     P=0.339      | 
|ORDER RESTRICTED   |                                                        |P=0.306      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    3/50 (6%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |3/43.69      3/46.42      2/42.02      2/45.37      | 
|POLY-3 PERCENT (g) |                                                        |6.9%         6.5%         4.8%         4.4%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    3/34 (9%)    2/28 (7%)    1/36 (3%)    | 
|FIRST INCIDENCE    |                                                        |593          730 (T)      730 (T)      684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.396N     P=0.629N     P=0.548N     P=0.473N     | 
|POLY 3             |                                                        |P=0.419N     P=0.634N     P=0.518N     P=0.483N     | 
|POLY 1.5           |                                                        |P=0.423N     P=0.639N     P=0.503N     P=0.485N     | 
|POLY 6             |                                                        |P=0.415N     P=0.636N     P=0.544N     P=0.484N     | 
|LOGISTIC REGRESSION|                                                        |P=0.425N     P=0.653      P=0.501N     P=0.521N     | 
|COCH-ARM / FISHERS |                                                        |P=0.429N     P=0.661N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.486N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/42.73      1/46.42      2/42.33      1/45.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.2%         4.7%         2.2%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    1/34 (3%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |                                                        |---          730 (T)      646          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.586      P=0.506      P=0.216      P=0.517      | 
|POLY 3             |                                                        |P=0.576      P=0.517      P=0.235      P=0.511      | 
|POLY 1.5           |                                                        |P=0.573      P=0.512      P=0.239      P=0.508      | 
|POLY 6             |                                                        |P=0.577      P=0.519      P=0.227      P=0.513      | 
|LOGISTIC REGRESSION|                                                        |P=0.570      P=0.506      P=0.238      P=0.517      | 
|COCH-ARM / FISHERS |                                                        |P=0.563      P=0.500      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.223      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      0/36.82      1/40.99     |0/42.54      0/46.42      2/42.44      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |0.0%         0.0%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          656         |---          ---          610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.224      (e)          (e)          P=0.494     |P=0.637N     (e)          P=0.222      (e)          | 
|POLY 3             |     P=0.223      (e)          (e)          P=0.496     |P=0.649N     (e)          P=0.236      (e)          | 
|POLY 1.5           |     P=0.227      (e)          (e)          P=0.499     |P=0.649N     (e)          P=0.241      (e)          | 
|POLY 6             |     P=0.217      (e)          (e)          P=0.491     |P=0.650N     (e)          P=0.228      (e)          | 
|LOGISTIC REGRESSION|     P=0.232      (e)          (e)          P=0.501     |P=0.655N     (e)          P=0.240      (e)          | 
|COCH-ARM / FISHERS |     P=0.230      (e)          (e)          P=0.500     |P=0.649N     (e)          P=0.253      (e)          | 
|ORDER RESTRICTED   |     P=0.116      (e)          (e)          (e)         |P=0.247      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Anterior Chamber, Cornea                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      0/36.82      2/40.73     |0/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          725         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.034 *    (e)          (e)          P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.231     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.224     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.033 *    (e)          (e)          P=0.200     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    10/50 (20%)  | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      0/36.82      0/40.72     |0/42.54      0/46.42      0/42.02      10/46.15     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         21.7%        | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    6/36 (17%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P=0.003 **   | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P=0.002 **   | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P<0.001 **   | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    4/50 (8%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      0/36.82      0/40.72     |1/42.54      4/47.01      3/42.44      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.4%         8.5%         7.1%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |1/33 (3%)    2/34 (6%)    2/28 (7%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      621          610          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.288N     P=0.204      P=0.264      P=0.742N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.291N     P=0.211      P=0.304      P=0.747N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.295N     P=0.204      P=0.312      P=0.749N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.288N     P=0.216      P=0.290      P=0.746N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.304N     P=0.186      P=0.305      P=0.742N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.306N     P=0.187      P=0.316      P=0.747N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.329N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   4/49 (8%)    7/50 (14%)  |0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/42.11      6/43.70      4/36.98      7/41.54     |0/42.73      3/46.93      1/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     16.6%        13.7%        10.8%        16.9%       |0.0%         6.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     5/27 (19%)   2/29 (7%)    3/16 (19%)   4/22 (18%)  |0/33 (0%)    1/34 (3%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     642          689          690          635         |---          642          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.335      P=0.438N     P=0.576N     P=0.488     |P=0.254N     P=0.140      P=0.467      (e)          | 
|POLY 3             |     P=0.461      P=0.471N     P=0.338N     P=0.605     |P=0.239N     P=0.136      P=0.497      (e)          | 
|POLY 1.5           |     P=0.468      P=0.480N     P=0.305N     P=0.610     |P=0.245N     P=0.131      P=0.501      (e)          | 
|POLY 6             |     P=0.443      P=0.460N     P=0.395N     P=0.589     |P=0.232N     P=0.141      P=0.488      (e)          | 
|LOGISTIC REGRESSION|     P=0.408      P=0.456N     P=0.463N     P=0.573     |P=0.262N     P=0.110      P=0.467      (e)          | 
|COCH-ARM / FISHERS |     P=0.475      P=0.500N     P=0.274N     P=0.613N    |P=0.263N     P=0.121      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.545      (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.84      0/43.38      1/36.90      0/40.72     |0/42.73      2/46.69      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.7%         0.0%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     712          ---          709          ---         |---          681          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.524N     P=0.494N     P=0.654      P=0.543N    |P=0.382N     P=0.257      (e)          (e)          | 
|POLY 3             |     P=0.488N     P=0.493N     P=0.732      P=0.505N    |P=0.365N     P=0.258      (e)          (e)          | 
|POLY 1.5           |     P=0.483N     P=0.495N     P=0.744      P=0.502N    |P=0.373N     P=0.252      (e)          (e)          | 
|POLY 6             |     P=0.497N     P=0.491N     P=0.713      P=0.512N    |P=0.357N     P=0.262      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.495N     P=0.490N     P=0.706      P=0.516N    |P=0.389N     P=0.236      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.477N     P=0.500N     P=0.747      P=0.500N    |P=0.390N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |0/42.54      2/46.71      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          676          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.383N     P=0.259      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.259      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.373N     P=0.254      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.359N     P=0.262      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.388N     P=0.237      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.388N     P=0.253      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  50/50 (100%) 49/49 (100%) 50/50 (100%)|45/49 (92%)  45/50 (90%)  45/50 (90%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     46/47.07     50/50.00     49/49.00     50/50.00    |45/47.07     45/50.00     45/48.46     49/49.06     | 
|POLY-3 PERCENT (g) |     97.7%        100.0%       100.0%       100.0%      |95.6%        90.0%        92.9%        99.9%        | 
|TERMINAL (d)       |     27/27 (100%) 29/29 (100%) 16/16 (100%) 22/22 (100%)|31/33 (94%)  29/34 (85%)  26/28 (93%)  36/36 (100%) | 
|FIRST INCIDENCE    |     458          464          361          254         |380          410          507          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.099      P=0.518      P=0.004 **   P=0.081     |P=0.511      P=0.413N     P=0.215      P=0.558      | 
|POLY 3             |     P=0.552      P=0.437      P=0.443      P=0.437     |P=0.058      P=0.252N     P=0.444N     P=0.225      | 
|POLY 1.5           |     P=0.268      P=0.169      P=0.173      P=0.169     |P=0.064      P=0.287N     P=0.399N     P=0.210      | 
|POLY 6             |     P=0.967      P=0.953      P=0.954      P=0.953     |P=0.057      P=0.243N     P=0.552N     P=0.228      | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.153      P=0.033 *    P=0.038 *   |P=0.097      P=0.331N     P=0.391N     P=0.321      | 
|COCH-ARM / FISHERS |     P=0.118      P=0.059      P=0.061      P=0.059     |P=0.088      P=0.513N     P=0.513N     P=0.175      | 
|ORDER RESTRICTED   |     P=0.010 *    (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/43.16      0/43.38      0/36.82      2/41.96     |0/42.54      0/46.42      0/42.02      1/45.76      | 
|POLY-3 PERCENT (g) |     9.3%         0.0%         0.0%         4.8%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     409          ---          ---          518         |---          ---          ---          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617      P=0.060N     P=0.103N     P=0.366N    |P=0.234      (e)          (e)          P=0.513      | 
|POLY 3             |     P=0.641      P=0.059N     P=0.082N     P=0.350N    |P=0.233      (e)          (e)          P=0.515      | 
|POLY 1.5           |     P=0.641      P=0.059N     P=0.073N     P=0.343N    |P=0.232      (e)          (e)          P=0.512      | 
|POLY 6             |     P=0.637      P=0.059N     P=0.100N     P=0.365N    |P=0.234      (e)          (e)          P=0.517      | 
|LOGISTIC REGRESSION|     P=0.636N     P=0.082N     P=0.054N     P=0.334N    |P=0.199      (e)          (e)          P=0.439      | 
|COCH-ARM / FISHERS |     P=0.640      P=0.059N     P=0.061N     P=0.339N    |P=0.229      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.036N*    (e)          (e)          (e)         |P=0.134      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    9/49 (18%)   17/50 (34%) |1/49 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.77      2/44.12      9/39.56      17/43.68    |1/42.54      2/46.60      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.5%         22.8%        38.9%       |2.4%         4.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    2/16 (13%)   8/22 (36%)  |1/33 (3%)    1/34 (3%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      464          509          509         |730 (T)      684          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.524      P=0.003 **   P<0.001 **  |P=0.563N     P=0.510      P=0.533N     P=0.742N     | 
|POLY 3             |     P<0.001 **   P=0.519      P=0.005 **   P<0.001 **  |P=0.578N     P=0.532      P=0.502N     P=0.747N     | 
|POLY 1.5           |     P<0.001 **   P=0.513      P=0.006 **   P<0.001 **  |P=0.582N     P=0.525      P=0.497N     P=0.749N     | 
|POLY 6             |     P<0.001 **   P=0.526      P=0.004 **   P<0.001 **  |P=0.572N     P=0.536      P=0.512N     P=0.746N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.463      P=0.010 *    P<0.001 **  |P=0.581N     P=0.529      (e)          P=0.742N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.007 **   P<0.001 **  |P=0.591N     P=0.508      P=0.495N     P=0.747N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    7/49 (14%)   19/50 (38%) |0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      3/44.04      7/37.38      19/42.97    |0/42.54      0/46.42      1/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         6.8%         18.7%        44.2%       |0.0%         0.0%         2.4%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    2/29 (7%)    2/16 (13%)   11/22 (50%) |0/33 (0%)    0/34 (0%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          509          646          537         |---          ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.135      P=0.002 **   P<0.001 **  |P=0.375      (e)          P=0.467      P=0.517      | 
|POLY 3             |     P<0.001 **   P=0.128      P=0.004 **   P<0.001 **  |P=0.352      (e)          P=0.498      P=0.512      | 
|POLY 1.5           |     P<0.001 **   P=0.125      P=0.005 **   P<0.001 **  |P=0.353      (e)          P=0.503      P=0.510      | 
|POLY 6             |     P<0.001 **   P=0.131      P=0.003 **   P<0.001 **  |P=0.351      (e)          P=0.488      P=0.513      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.107      P=0.003 **   P<0.001 **  |(e)          (e)          P=0.467      P=0.517      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P=0.006 **   P<0.001 **  |P=0.351      (e)          P=0.505      P=0.505      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    8/50 (16%)   28/49 (57%)  41/50 (82%) |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      8/45.03      28/44.48     41/48.81    |0/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         17.8%        63.0%        84.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    4/29 (14%)   8/16 (50%)   17/22 (77%) |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          509          361          254         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |13/49 (27%)  5/50 (10%)   7/50 (14%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |13/43.31     5/47.52      7/42.02      3/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |30.0%        10.5%        16.7%        6.6%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |11/33 (33%)  3/34 (9%)    7/28 (25%)   2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |537          410          730 (T)      675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.020N*    P=0.030N*    P=0.184N     P=0.005N**   | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.025N*    P=0.017N*    P=0.112N     P=0.004N**   | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.025N*    P=0.020N*    P=0.098N     P=0.004N**   | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.024N*    P=0.016N*    P=0.140N     P=0.003N**   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.025N*    P=0.029N*    P=0.133N     P=0.005N**   | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.026N*    P=0.030N*    P=0.096N     P=0.005N**   | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    6/49 (12%)   15/50 (30%) |0/49 (0%)    4/50 (8%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.04      1/43.38      6/36.90      15/42.80    |0/42.54      4/47.00      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         2.3%         16.3%        35.1%       |0.0%         8.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    4/16 (25%)   8/22 (36%)  |0/33 (0%)    2/34 (6%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     655          729 (T)      718          509         |---          642          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.477N     P=0.033 *    P<0.001 **  |P=0.186N     P=0.077      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.489N     P=0.092      P<0.001 **  |P=0.164N     P=0.074      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.492N     P=0.108      P<0.001 **  |P=0.170N     P=0.071      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.487N     P=0.071      P<0.001 **  |P=0.157N     P=0.077      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.487N     P=0.050      P<0.001 **  |P=0.190N     P=0.061      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.128      P<0.001 **  |P=0.190N     P=0.061      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.116N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.70      0/43.38      0/36.82      0/40.72     |0/42.54      0/46.42      2/43.15      0/45.19      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     296          ---          ---          ---         |---          ---          471          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.550N     P=0.500N     P=0.504N     P=0.504N    |P=0.647N     (e)          P=0.246      (e)          | 
|POLY 3             |     P=0.542N     P=0.497N     P=0.529N     P=0.510N    |P=0.649N     (e)          P=0.240      (e)          | 
|POLY 1.5           |     P=0.544N     P=0.498N     P=0.518N     P=0.505N    |P=0.648N     (e)          P=0.244      (e)          | 
|POLY 6             |     P=0.541N     P=0.495N     P=0.547N     P=0.517N    |P=0.649N     (e)          P=0.233      (e)          | 
|LOGISTIC REGRESSION|     P=0.277N     (e)          (e)          P=0.422N    |P=0.698N     (e)          P=0.150      (e)          | 
|COCH-ARM / FISHERS |     P=0.546N     P=0.500N     P=0.505N     P=0.500N    |P=0.649N     (e)          P=0.253      (e)          | 
|ORDER RESTRICTED   |     P=0.129N     (e)          (e)          (e)         |P=0.250      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      2/37.29      0/40.72     |0/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         5.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          590          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475N     P=0.486N     P=0.364      P=0.541N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.454N     P=0.492N     P=0.460      P=0.505N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.446N     P=0.495N     P=0.477      P=0.502N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.469N     P=0.490N     P=0.435      P=0.512N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.439N     (e)          P=0.469      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.436N     P=0.500N     P=0.492      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.320N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    1/48 (2%)    1/50 (2%)   |1/49 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      2/43.52      1/35.95      1/40.97     |1/42.54      1/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.6%         2.8%         2.4%        |2.4%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |1/33 (3%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      621          729 (T)      662         |730 (T)      730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.592N     P=0.521      P=0.641      P=0.734     |P=0.333N     P=0.755N     P=0.533N     P=0.483N     | 
|POLY 3             |     P=0.549N     P=0.514      P=0.727      P=0.757     |P=0.341N     P=0.741N     P=0.502N     P=0.488N     | 
|POLY 1.5           |     P=0.546N     P=0.506      P=0.739      P=0.759     |P=0.344N     P=0.745N     P=0.497N     P=0.490N     | 
|POLY 6             |     P=0.558N     P=0.525      P=0.706      P=0.751     |P=0.337N     P=0.739N     P=0.512N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.548N     P=0.483      P=0.641      P=0.757     |P=0.333N     P=0.755N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.492      P=0.742      P=0.753N    |P=0.346N     P=0.747N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.605N     (e)          (e)          (e)         |P=0.240N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/48 (2%)    0/50 (0%)   |4/49 (8%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.77      2/43.28      1/36.08      0/40.72     |4/43.48      2/46.42      1/42.02      2/45.21      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         2.8%         0.0%        |9.2%         4.3%         2.4%         4.4%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |3/33 (9%)    2/34 (6%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          621          697          ---         |284          730 (T)      730 (T)      726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.248      P=0.422      (e)         |P=0.392N     P=0.325N     P=0.221N     P=0.305N     | 
|POLY 3             |     P=0.364N     P=0.245      P=0.471      (e)         |P=0.424N     P=0.307N     P=0.189N     P=0.319N     | 
|POLY 1.5           |     P=0.362N     P=0.241      P=0.481      (e)         |P=0.426N     P=0.313N     P=0.179N     P=0.321N     | 
|POLY 6             |     P=0.371N     P=0.251      P=0.455      (e)         |P=0.419N     P=0.304N     P=0.204N     P=0.317N     | 
|LOGISTIC REGRESSION|     P=0.367N     P=0.227      P=0.462      (e)         |P=0.432N     P=0.390N     P=0.184N     P=0.357N     | 
|COCH-ARM / FISHERS |     P=0.363N     P=0.242      P=0.490      (e)         |P=0.426N     P=0.329N     P=0.175N     P=0.329N     | 
|ORDER RESTRICTED   |     P=0.314      (e)          (e)          (e)         |P=0.168N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/48 (0%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/42.90      0/35.95      3/41.57     |0/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         7.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          635         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    P=0.486N     P=0.604N     P=0.274     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.047 *    P=0.495N     P=0.530N     P=0.303     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.048 *    P=0.498N     P=0.519N     P=0.305     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.046 *    P=0.491N     P=0.547N     P=0.297     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.050      (e)          (e)          P=0.305     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.050      P=0.505N     P=0.510N     P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.038 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Epiglottis                                                                                                               | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/48 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      1/35.95      0/40.72     |0/42.54      0/46.42      1/42.02      2/45.21      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.8%         0.0%        |0.0%         0.0%         2.4%         4.4%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          730 (T)      726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.796N     (e)          P=0.396      (e)         |P=0.119      (e)          P=0.467      P=0.262      | 
|POLY 3             |     P=0.777N     (e)          P=0.470      (e)         |P=0.099      (e)          P=0.498      P=0.251      | 
|POLY 1.5           |     P=0.773N     (e)          P=0.481      (e)         |P=0.099      (e)          P=0.503      P=0.249      | 
|POLY 6             |     P=0.784N     (e)          P=0.453      (e)         |P=0.099      (e)          P=0.488      P=0.252      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.396      (e)         |P=0.114      (e)          P=0.467      P=0.256      | 
|COCH-ARM / FISHERS |     P=0.769N     (e)          P=0.490      (e)         |P=0.098      (e)          P=0.505      P=0.253      | 
|ORDER RESTRICTED   |     P=0.355      (e)          (e)          (e)         |P=0.083      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |1/42.54      0/46.42      3/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.4%         0.0%         7.1%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |1/33 (3%)    0/34 (0%)    3/28 (11%)   1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.649      P=0.494N     P=0.247      P=0.742N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.620      P=0.483N     P=0.300      P=0.747N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.622      P=0.486N     P=0.310      P=0.749N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.619      P=0.481N     P=0.284      P=0.746N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.649      (e)          P=0.247      P=0.742N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.622      P=0.495N     P=0.316      P=0.747N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   18/50 (36%)  15/49 (31%)  17/50 (34%) |39/49 (80%)  45/50 (90%)  43/50 (86%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     6/42.12      18/44.18     15/37.71     17/42.84    |39/44.81     45/48.66     43/47.26     40/46.57     | 
|POLY-3 PERCENT (g) |     14.2%        40.7%        39.8%        39.7%       |87.0%        92.5%        91.0%        85.9%        | 
|TERMINAL (d)       |     5/27 (19%)   14/29 (48%)  13/16 (81%)  9/22 (41%)  |32/33 (97%)  34/34 (100%) 27/28 (96%)  32/36 (89%)  | 
|FIRST INCIDENCE    |     630          642          550          550         |537          621          471          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030 *    P=0.008 **   P<0.001 **   P=0.004 **  |P=0.128N     P=0.238      P=0.044 *    P=0.384N     | 
|POLY 3             |     P=0.101      P=0.004 **   P=0.007 **   P=0.006 **  |P=0.291N     P=0.285      P=0.382      P=0.562N     | 
|POLY 1.5           |     P=0.104      P=0.004 **   P=0.012 *    P=0.007 **  |P=0.271N     P=0.232      P=0.382      P=0.555N     | 
|POLY 6             |     P=0.093      P=0.005 **   P=0.003 **   P=0.005 **  |P=0.323N     P=0.330      P=0.353      P=0.586N     | 
|LOGISTIC REGRESSION|     P=0.065      P=0.006 **   P=0.002 **   P=0.006 **  |P=0.201N     P=0.360      P=0.234      P=0.454N     | 
|COCH-ARM / FISHERS |     P=0.110      P=0.005 **   P=0.021 *    P=0.008 **  |P=0.292N     P=0.122      P=0.282      P=0.579      | 
|ORDER RESTRICTED   |     P=0.005 **   (e)          (e)          (e)         |P=0.373N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   11/50 (22%)  11/49 (22%)  9/50 (18%)  |12/49 (24%)  13/50 (26%)  11/50 (22%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     8/41.77      11/43.38     11/36.82     9/41.77     |12/43.47     13/46.89     11/43.06     27/45.63     | 
|POLY-3 PERCENT (g) |     19.2%        25.4%        29.9%        21.6%       |27.6%        27.7%        25.5%        59.2%        | 
|TERMINAL (d)       |     8/27 (30%)   11/29 (38%)  11/16 (69%)  5/22 (23%)  |10/33 (30%)  10/34 (29%)  6/28 (21%)   23/36 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      612         |558          656          610          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413      P=0.356      P=0.016 *    P=0.344     |P<0.001 **   P=0.550      P=0.542      P=0.005 **   | 
|POLY 3             |     P=0.506N     P=0.334      P=0.196      P=0.500     |P<0.001 **   P=0.588      P=0.511N     P=0.002 **   | 
|POLY 1.5           |     P=0.502N     P=0.325      P=0.240      P=0.502     |P<0.001 **   P=0.574      P=0.483N     P=0.002 **   | 
|POLY 6             |     P=0.519N     P=0.343      P=0.135      P=0.491     |P<0.001 **   P=0.593N     P=0.553N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.481      P=0.356      P=0.016 *    P=0.430     |P<0.001 **   P=0.590N     P=0.511N     P=0.003 **   | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.306      P=0.288      P=0.500     |P<0.001 **   P=0.523      P=0.478N     P=0.002 **   | 
|ORDER RESTRICTED   |     P=0.390      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      1/37.00      3/41.32     |0/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.7%         7.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          684          635         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068      P=0.486N     P=0.668      P=0.270     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.076      P=0.492N     P=0.733      P=0.301     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.078      P=0.495N     P=0.745      P=0.304     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.072      P=0.490N     P=0.715      P=0.293     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.079      (e)          P=0.714      P=0.300     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.081      P=0.500N     P=0.747      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.077      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/49 (2%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/43.38      1/36.82      2/40.96     |1/42.54      0/46.42      0/42.02      1/45.42      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.7%         4.9%        |2.4%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      663         |730 (T)      ---          ---          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176      P=0.514      P=0.396      P=0.211     |P=0.539      P=0.494N     P=0.533N     P=0.743N     | 
|POLY 3             |     P=0.208      P=0.508      P=0.475      P=0.232     |P=0.522      P=0.483N     P=0.502N     P=0.746N     | 
|POLY 1.5           |     P=0.212      P=0.505      P=0.485      P=0.235     |P=0.522      P=0.486N     P=0.497N     P=0.748N     | 
|POLY 6             |     P=0.199      P=0.510      P=0.458      P=0.226     |P=0.524      P=0.481N     P=0.512N     P=0.744N     | 
|LOGISTIC REGRESSION|     P=0.194      P=0.514      P=0.396      P=0.231     |P=0.526      (e)          (e)          P=0.755N     | 
|COCH-ARM / FISHERS |     P=0.215      P=0.500      P=0.495      P=0.247     |P=0.525      P=0.495N     P=0.495N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.114      (e)          (e)          (e)         |P=0.382N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/42.34      0/43.38      0/36.82      1/41.01     |0/42.54      1/46.68      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     7.1%         0.0%         0.0%         2.4%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     630          ---          ---          648         |---          660          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.561N     P=0.113N     P=0.191N     P=0.342N    |P=0.599N     P=0.519      (e)          (e)          | 
|POLY 3             |     P=0.534N     P=0.114N     P=0.145N     P=0.316N    |P=0.591N     P=0.518      (e)          (e)          | 
|POLY 1.5           |     P=0.533N     P=0.115N     P=0.133N     P=0.310N    |P=0.596N     P=0.515      (e)          (e)          | 
|POLY 6             |     P=0.537N     P=0.113N     P=0.166N     P=0.330N    |P=0.585N     P=0.521      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.530N     P=0.121N     P=0.129N     P=0.304N    |P=0.613N     P=0.478      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.531N     P=0.121N     P=0.125N     P=0.309N    |P=0.607N     P=0.505      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.042N*    (e)          (e)          (e)         |P=0.388N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   11/49 (22%)  5/50 (10%)  |8/49 (16%)   10/50 (20%)  9/50 (18%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/41.77      6/44.33      11/39.71     5/42.18     |8/43.23      10/46.42     9/43.72      7/45.90      | 
|POLY-3 PERCENT (g) |     2.4%         13.5%        27.7%        11.9%       |18.5%        21.5%        20.6%        15.3%        | 
|TERMINAL (d)       |     1/27 (4%)    4/29 (14%)   4/16 (25%)   0/22 (0%)   |6/33 (18%)   10/34 (29%)  5/28 (18%)   5/36 (14%)   | 
|FIRST INCIDENCE    |     729 (T)      509          431          598         |593          730 (T)      507          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381      P=0.073      P<0.001 **   P=0.094     |P=0.268N     P=0.431      P=0.397      P=0.437N     | 
|POLY 3             |     P=0.445      P=0.065      P<0.001 **   P=0.102     |P=0.302N     P=0.462      P=0.510      P=0.450N     | 
|POLY 1.5           |     P=0.451      P=0.062      P<0.001 **   P=0.103     |P=0.310N     P=0.454      P=0.526      P=0.457N     | 
|POLY 6             |     P=0.431      P=0.069      P<0.001 **   P=0.100     |P=0.290N     P=0.460      P=0.479      P=0.444N     | 
|LOGISTIC REGRESSION|     P=0.467      P=0.059      P=0.003 **   P=0.104     |P=0.317N     P=0.484      P=0.518      P=0.463N     | 
|COCH-ARM / FISHERS |     P=0.457      P=0.056      P=0.002 **   P=0.102     |P=0.325N     P=0.416      P=0.518      P=0.483N     | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.435N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |1/42.54      0/46.42      1/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.4%         0.0%         2.4%         4.4%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |1/33 (3%)    0/34 (0%)    1/28 (4%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.271      P=0.494N     P=0.725      P=0.530      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.240      P=0.483N     P=0.758      P=0.521      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.241      P=0.486N     P=0.757N     P=0.518      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.241      P=0.481N     P=0.748      P=0.523      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.271      (e)          P=0.725      P=0.530      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.241      P=0.495N     P=0.747N     P=0.508      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.240      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/49 (6%)    1/50 (2%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      3/37.72      1/41.36     |0/42.54      1/46.61      1/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.0%         2.4%        |0.0%         2.2%         2.4%         4.4%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    1/28 (4%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          590          518         |---          681          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454      (e)          P=0.081      P=0.508     |P=0.243      P=0.515      P=0.467      P=0.258      | 
|POLY 3             |     P=0.449      (e)          P=0.100      P=0.498     |P=0.224      P=0.518      P=0.498      P=0.251      | 
|POLY 1.5           |     P=0.459      (e)          P=0.108      P=0.500     |P=0.223      P=0.515      P=0.503      P=0.249      | 
|POLY 6             |     P=0.429      (e)          P=0.090      P=0.493     |P=0.225      P=0.521      P=0.488      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.487      (e)          P=0.124      P=0.502     |P=0.226      P=0.494      P=0.467      P=0.258      | 
|COCH-ARM / FISHERS |     P=0.469      (e)          P=0.117      P=0.500     |P=0.217      P=0.505      P=0.505      P=0.253      | 
|ORDER RESTRICTED   |     P=0.098      (e)          (e)          (e)         |P=0.130      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/49 (4%)    1/50 (2%)   |3/49 (6%)    4/50 (8%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/42.78      1/44.04      2/37.35      1/41.29     |3/44.82      4/46.94      3/42.86      0/45.19      | 
|POLY-3 PERCENT (g) |     7.0%         2.3%         5.4%         2.4%        |6.7%         8.5%         7.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     465          509          646          550         |284          660          528          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.386N     P=0.289N     P=0.609N     P=0.326N    |P=0.062N     P=0.530      P=0.643      P=0.122N     | 
|POLY 3             |     P=0.380N     P=0.295N     P=0.562N     P=0.318N    |P=0.060N     P=0.525      P=0.642      P=0.117N     | 
|POLY 1.5           |     P=0.373N     P=0.298N     P=0.537N     P=0.311N    |P=0.060N     P=0.522      P=0.657      P=0.116N     | 
|POLY 6             |     P=0.395N     P=0.291N     P=0.598N     P=0.330N    |P=0.061N     P=0.528      P=0.621      P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.336N     P=0.400N     P=0.481N     P=0.301N    |P=0.065N     P=0.261      P=0.523      P=0.206N     | 
|COCH-ARM / FISHERS |     P=0.364N     P=0.309N     P=0.510N     P=0.309N    |P=0.059N     P=0.511      P=0.651N     P=0.117N     | 
|ORDER RESTRICTED   |     P=0.233N     (e)          (e)          (e)         |P=0.086N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/49 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.70      2/43.38      1/36.82      1/40.72     |1/42.79      2/46.60      0/42.02      1/45.59      | 
|POLY-3 PERCENT (g) |     2.3%         4.6%         2.7%         2.5%        |2.3%         4.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    2/29 (7%)    1/16 (6%)    1/22 (5%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     296          729 (T)      729 (T)      729 (T)     |715          683          ---          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.608N     P=0.517      P=0.701      P=0.735     |P=0.570N     P=0.519      P=0.545N     P=0.741N     | 
|POLY 3             |     P=0.558N     P=0.505      P=0.727      P=0.750     |P=0.576N     P=0.530      P=0.504N     P=0.746N     | 
|POLY 1.5           |     P=0.554N     P=0.503      P=0.740      P=0.755     |P=0.583N     P=0.522      P=0.499N     P=0.750N     | 
|POLY 6             |     P=0.569N     P=0.509      P=0.706      P=0.742     |P=0.568N     P=0.535      P=0.512N     P=0.743N     | 
|LOGISTIC REGRESSION|     P=0.539N     P=0.393      P=0.767      P=0.772     |P=0.596N     P=0.522      P=0.511N     P=0.755      | 
|COCH-ARM / FISHERS |     P=0.548N     P=0.500      P=0.747      P=0.753N    |P=0.594N     P=0.500      P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.610N     (e)          (e)          (e)         |P=0.387N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      1/37.37      2/40.94     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.7%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          561          684         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.087      (e)          P=0.486      P=0.209     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.091      (e)          P=0.478      P=0.232     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.094      (e)          P=0.487      P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.086      (e)          P=0.463      P=0.226     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.099      (e)          P=0.506      P=0.229     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.098      (e)          P=0.495      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.071      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    5/49 (10%)   4/50 (8%)   |9/50 (18%)   2/50 (4%)    7/50 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     5/42.87      2/43.38      5/37.19      4/41.52     |9/43.26      2/46.42      7/42.22      6/45.19      | 
|POLY-3 PERCENT (g) |     11.7%        4.6%         13.4%        9.6%        |20.8%        4.3%         16.6%        13.3%        | 
|TERMINAL (d)       |     3/27 (11%)   2/29 (7%)    2/16 (13%)   2/22 (9%)   |7/33 (21%)   2/34 (6%)    5/28 (18%)   6/36 (17%)   | 
|FIRST INCIDENCE    |     458          729 (T)      656          550         |587          730 (T)      698          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.470      P=0.195N     P=0.375      P=0.574N    |P=0.503N     P=0.024N*    P=0.524N     P=0.230N     | 
|POLY 3             |     P=0.543      P=0.210N     P=0.539      P=0.520N    |P=0.580      P=0.018N*    P=0.412N     P=0.255N     | 
|POLY 1.5           |     P=0.553      P=0.212N     P=0.577      P=0.510N    |P=0.580      P=0.019N*    P=0.391N     P=0.262N     | 
|POLY 6             |     P=0.521      P=0.209N     P=0.481      P=0.540N    |P=0.582N     P=0.017N*    P=0.450N     P=0.252N     | 
|LOGISTIC REGRESSION|     P=0.557      P=0.220N     P=0.577      P=0.497N    |P=0.545N     P=0.019N*    P=0.447N     P=0.241N     | 
|COCH-ARM / FISHERS |     P=0.566      P=0.218N     P=0.617      P=0.500N    |P=0.581      P=0.026N*    P=0.393N     P=0.288N     | 
|ORDER RESTRICTED   |     P=0.475      (e)          (e)          (e)         |P=0.142N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    5/49 (10%)   6/50 (12%)  |6/50 (12%)   4/50 (8%)    5/50 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     6/42.47      2/44.04      5/36.88      6/41.16     |6/42.79      4/46.42      5/42.20      4/45.19      | 
|POLY-3 PERCENT (g) |     14.1%        4.5%         13.6%        14.6%       |14.0%        8.6%         11.9%        8.9%         | 
|TERMINAL (d)       |     4/27 (15%)   1/29 (3%)    4/16 (25%)   5/22 (23%)  |5/33 (15%)   4/34 (12%)   4/28 (14%)   4/36 (11%)   | 
|FIRST INCIDENCE    |     630          509          716          598         |715          730 (T)      682          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227      P=0.122N     P=0.434      P=0.504     |P=0.348N     P=0.347N     P=0.614N     P=0.314N     | 
|POLY 3             |     P=0.290      P=0.120N     P=0.599N     P=0.600     |P=0.403N     P=0.319N     P=0.510N     P=0.335N     | 
|POLY 1.5           |     P=0.305      P=0.124N     P=0.557N     P=0.612     |P=0.407N     P=0.332N     P=0.496N     P=0.344N     | 
|POLY 6             |     P=0.262      P=0.117N     P=0.591      P=0.573     |P=0.397N     P=0.312N     P=0.537N     P=0.329N     | 
|LOGISTIC REGRESSION|     P=0.295      P=0.137N     P=0.580      P=0.594     |P=0.369N     P=0.316N     P=0.580N     P=0.312N     | 
|COCH-ARM / FISHERS |     P=0.324      P=0.134N     P=0.514N     P=0.620N    |P=0.414N     P=0.370N     P=0.500N     P=0.370N     | 
|ORDER RESTRICTED   |     P=0.350      (e)          (e)          (e)         |P=0.347N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      0/36.82      4/42.33     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         9.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          518         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.486N     P=0.604N     P=0.171     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.011 *    P=0.492N     P=0.525N     P=0.182     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.011 *    P=0.495N     P=0.515N     P=0.182     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.011 *    P=0.490N     P=0.542N     P=0.179     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.013 *    (e)          (e)          P=0.180     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.012 *    P=0.500N     P=0.505N     P=0.181     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      2/40.89     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          684         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.203     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.232     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.225     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.039 *    (e)          (e)          P=0.224     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.028 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  3/50 (6%)    8/49 (16%)   8/50 (16%)  |15/50 (30%)  9/50 (18%)   13/50 (26%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     11/43.73     3/43.38      8/37.65      8/41.58     |15/43.93     9/46.70      13/42.71     20/45.99     | 
|POLY-3 PERCENT (g) |     25.2%        6.9%         21.3%        19.2%       |34.1%        19.3%        30.4%        43.5%        | 
|TERMINAL (d)       |     7/27 (26%)   3/29 (10%)   4/16 (25%)   6/22 (27%)  |11/33 (33%)  7/34 (21%)   11/28 (39%)  18/36 (50%)  | 
|FIRST INCIDENCE    |     296          729 (T)      593          550         |587          660          528          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.367      P=0.018N*    P=0.516      P=0.440N    |P=0.068      P=0.104N     P=0.584      P=0.296      | 
|POLY 3             |     P=0.472      P=0.019N*    P=0.439N     P=0.345N    |P=0.031 *    P=0.084N     P=0.444N     P=0.243      | 
|POLY 1.5           |     P=0.488      P=0.019N*    P=0.384N     P=0.327N    |P=0.031 *    P=0.091N     P=0.411N     P=0.236      | 
|POLY 6             |     P=0.441      P=0.019N*    P=0.525N     P=0.381N    |P=0.031 *    P=0.083N     P=0.513N     P=0.241      | 
|LOGISTIC REGRESSION|     P=0.489      P=0.022N*    P=0.365N     P=0.307N    |P=0.038 *    P=0.080N     P=0.449N     P=0.257      | 
|COCH-ARM / FISHERS |     P=0.509      P=0.020N*    P=0.323N     P=0.306N    |P=0.031 *    P=0.121N     P=0.412N     P=0.201      | 
|ORDER RESTRICTED   |     P=0.181N     (e)          (e)          (e)         |P=0.055      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Proteinosis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/43.38      0/36.82      0/40.72     |4/43.21      0/46.42      3/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |9.3%         0.0%         7.1%         4.4%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |3/33 (9%)    0/34 (0%)    3/28 (11%)   2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |587          ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.639N     P=0.514      (e)          (e)         |P=0.515N     P=0.058N     P=0.578N     P=0.303N     | 
|POLY 3             |     P=0.598N     P=0.508      (e)          (e)         |P=0.565N     P=0.052N     P=0.515N     P=0.316N     | 
|POLY 1.5           |     P=0.601N     P=0.505      (e)          (e)         |P=0.564N     P=0.054N     P=0.501N     P=0.321N     | 
|POLY 6             |     P=0.595N     P=0.510      (e)          (e)         |P=0.564N     P=0.051N     P=0.542N     P=0.314N     | 
|LOGISTIC REGRESSION|     (e)          P=0.514      (e)          (e)         |P=0.544N     P=0.059N     P=0.518N     P=0.318N     | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.558N     P=0.059N     P=0.500N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.392N     (e)          (e)          (e)         |P=0.184N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    4/49 (8%)    6/50 (12%)  |4/50 (8%)    1/50 (2%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/42.53      1/43.38      4/36.92      6/41.04     |4/42.73      1/46.42      4/42.14      2/45.19      | 
|POLY-3 PERCENT (g) |     11.8%        2.3%         10.8%        14.6%       |9.4%         2.2%         9.5%         4.4%         | 
|TERMINAL (d)       |     3/27 (11%)   1/29 (3%)    2/16 (13%)   4/22 (18%)  |4/33 (12%)   1/34 (3%)    3/28 (11%)   2/36 (6%)    | 
|FIRST INCIDENCE    |     604          729 (T)      716          656         |730 (T)      730 (T)      698          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.115      P=0.095N     P=0.508      P=0.393     |P=0.398N     P=0.169N     P=0.554      P=0.296N     | 
|POLY 3             |     P=0.154      P=0.096N     P=0.589N     P=0.475     |P=0.446N     P=0.154N     P=0.636      P=0.311N     | 
|POLY 1.5           |     P=0.163      P=0.097N     P=0.551N     P=0.489     |P=0.446N     P=0.161N     P=0.640N     P=0.318N     | 
|POLY 6             |     P=0.138      P=0.095N     P=0.631      P=0.447     |P=0.443N     P=0.151N     P=0.615      P=0.306N     | 
|LOGISTIC REGRESSION|     P=0.144      P=0.098N     P=0.626N     P=0.473     |P=0.411N     P=0.169N     P=0.573      P=0.296N     | 
|COCH-ARM / FISHERS |     P=0.175      P=0.102N     P=0.513N     P=0.500     |P=0.447N     P=0.181N     P=0.643N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.180      (e)          (e)          (e)         |P=0.270N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/24 (0%)    0/7 (0%)     0/9 (0%)     2/21 (10%)  |0/9 (0%)     0/4 (0%)     0/10 (0%)    0/5 (0%)     | 
|POLY-3 RATE (b)    |     0/22.07      0/6.46       0/6.49       2/16.51     |0/7.10       0/3.68       0/7.79       0/4.28       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         12.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/16 (0%)    0/4 (0%)     0/1 (0%)     1/7 (14%)   |0/4 (0%)     0/3 (0%)     0/2 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          631         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    (e)          (e)          P=0.153     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.070      (e)          (e)          P=0.172     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.076      (e)          (e)          P=0.184     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.063      (e)          (e)          P=0.159     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.078      (e)          (e)          P=0.195     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.088      (e)          (e)          P=0.212     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/38 (0%)    1/41 (2%)    1/46 (2%)    0/45 (0%)   |3/43 (7%)    1/46 (2%)    1/45 (2%)    2/43 (5%)    | 
|POLY-3 RATE (b)    |     0/30.56      1/35.62      1/35.14      0/36.79     |3/37.24      1/42.68      1/37.71      2/39.50      | 
|POLY-3 PERCENT (g) |     0.0%         2.8%         2.9%         0.0%        |8.1%         2.3%         2.7%         5.1%         | 
|TERMINAL (d)       |     0/17 (0%)    1/23 (4%)    0/16 (0%)    0/21 (0%)   |2/28 (7%)    1/32 (3%)    1/26 (4%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      722          ---         |284          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.528N     P=0.560      P=0.400      (e)         |P=0.612N     P=0.270N     P=0.324N     P=0.451N     | 
|POLY 3             |     P=0.489N     P=0.530      P=0.528      (e)         |P=0.629      P=0.257N     P=0.300N     P=0.473N     | 
|POLY 1.5           |     P=0.491N     P=0.525      P=0.533      (e)         |P=0.627      P=0.264N     P=0.291N     P=0.479N     | 
|POLY 6             |     P=0.487N     P=0.539      P=0.520      (e)         |P=0.632      P=0.253N     P=0.315N     P=0.468N     | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.560      P=0.506      (e)         |P=0.594      P=0.379N     P=0.325N     P=0.588N     | 
|COCH-ARM / FISHERS |     P=0.495N     P=0.519      P=0.548      (e)         |P=0.623      P=0.283N     P=0.291N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.404N     (e)          (e)          (e)         |P=0.257N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/38 (0%)    0/41 (0%)    0/46 (0%)    0/45 (0%)   |1/43 (2%)    2/46 (4%)    4/45 (9%)    0/43 (0%)    | 
|POLY-3 RATE (b)    |     0/30.56      0/35.62      0/35.11      0/36.79     |1/36.30      2/42.96      4/38.13      0/39.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.8%         4.7%         10.5%        0.0%         | 
|TERMINAL (d)       |     0/17 (0%)    0/23 (0%)    0/16 (0%)    0/21 (0%)   |1/28 (4%)    1/32 (3%)    3/26 (12%)   0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      656          610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.205N     P=0.547      P=0.163      P=0.473N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.209N     P=0.558      P=0.192      P=0.483N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.213N     P=0.549      P=0.197      P=0.487N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.565      P=0.181      P=0.480N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.221N     P=0.545      P=0.187      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.229N     P=0.526      P=0.195      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.166N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/38 (0%)    0/41 (0%)    0/46 (0%)    0/45 (0%)   |3/43 (7%)    1/46 (2%)    0/45 (0%)    0/43 (0%)    | 
|POLY-3 RATE (b)    |     0/30.56      0/35.62      0/35.11      0/36.79     |3/36.30      1/43.07      0/37.71      0/39.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.3%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/17 (0%)    0/23 (0%)    0/16 (0%)    0/21 (0%)   |3/28 (11%)   0/32 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      621          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.258N     P=0.133N     P=0.098N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.137N     P=0.246N     P=0.110N     P=0.103N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.137N     P=0.256N     P=0.108N     P=0.107N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.136N     P=0.239N     P=0.117N     P=0.101N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.133N     P=0.261N     (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.137N     P=0.283N     P=0.112N     P=0.121N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/49 (4%)    1/50 (2%)   |0/49 (0%)    7/50 (14%)   2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.00      2/43.74      2/36.87      1/40.97     |0/42.54      7/46.77      2/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     7.1%         4.6%         5.4%         2.4%        |0.0%         15.0%        4.8%         2.2%         | 
|TERMINAL (d)       |     2/27 (7%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |0/33 (0%)    5/34 (15%)   2/28 (7%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     668          656          718          662         |---          660          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.353N     P=0.462N     P=0.657      P=0.359N    |P=0.190N     P=0.012 *    P=0.202      P=0.517      | 
|POLY 3             |     P=0.298N     P=0.481N     P=0.559N     P=0.314N    |P=0.182N     P=0.011 *    P=0.234      P=0.512      | 
|POLY 1.5           |     P=0.292N     P=0.487N     P=0.534N     P=0.309N    |P=0.189N     P=0.010 *    P=0.240      P=0.510      | 
|POLY 6             |     P=0.310N     P=0.474N     P=0.599N     P=0.325N    |P=0.175N     P=0.011 *    P=0.224      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.302N     P=0.487N     P=0.636N     P=0.314N    |P=0.202N     P=0.013 *    P=0.202      P=0.517      | 
|COCH-ARM / FISHERS |     P=0.285N     P=0.500N     P=0.510N     P=0.309N    |P=0.211N     P=0.007 **   P=0.253      P=0.505      | 
|ORDER RESTRICTED   |     P=0.254N     (e)          (e)          (e)         |P=0.094      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/13 (100%) 9/9 (100%)   10/10 (100%) 5/7 (71%)   |17/17 (100%) 21/23 (91%)  9/10 (90%)   17/17 (100%) | 
|POLY-3 RATE (b)    |     13/13.00     9/9.00       10/10.00     5/6.98      |17/17.00     21/22.68     9/9.54       17/17.00     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       71.6%       |100.0%       92.6%        94.4%        100.0%       | 
|TERMINAL (d)       |     10/10 (100%) 5/5 (100%)   2/2 (100%)   1/2 (50%)   |11/11 (100%) 14/15 (93%)  7/7 (100%)   15/15 (100%) | 
|FIRST INCIDENCE    |     655          513          565          598         |415          621          509          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.463N     (e)          (e)          P=0.587N    |P=0.117N     P=0.557N     P=0.164N     (e)          | 
|POLY 3             |     P=0.008N**   (e)          (e)          P=0.093N    |P=0.441      P=0.355N     P=0.727N     (e)          | 
|POLY 1.5           |     P=0.007N**   (e)          (e)          P=0.092N    |P=0.416      P=0.329N     P=0.539N     (e)          | 
|POLY 6             |     P=0.008N**   (e)          (e)          P=0.094N    |P=0.491      P=0.405N     P=0.987N     (e)          | 
|LOGISTIC REGRESSION|     P=0.003N**   (e)          (e)          P=0.025N*   |P=0.487      P=0.282N     P=0.395N     (e)          | 
|COCH-ARM / FISHERS |     P=0.013N*    (e)          (e)          P=0.111N    |P=0.393      P=0.324N     P=0.370N     (e)          | 
|ORDER RESTRICTED   |     P=0.005N**   (e)          (e)          (e)         |P=0.323      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/49 (12%)   4/49 (8%)    3/50 (6%)   |2/49 (4%)    2/49 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/43.21      6/43.99      4/37.98      3/40.89     |2/42.54      2/45.60      2/42.68      0/45.19      | 
|POLY-3 PERCENT (g) |     13.9%        13.6%        10.5%        7.3%        |4.7%         4.4%         4.7%         0.0%         | 
|TERMINAL (d)       |     2/27 (7%)    3/29 (10%)   0/16 (0%)    1/22 (5%)   |2/33 (6%)    2/34 (6%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     539          591          593          698         |730 (T)      730 (T)      509          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.587N     P=0.564N     P=0.320N    |P=0.144N     P=0.685N     P=0.653      P=0.219N     | 
|POLY 3             |     P=0.206N     P=0.609N     P=0.452N     P=0.268N    |P=0.150N     P=0.669N     P=0.693N     P=0.224N     | 
|POLY 1.5           |     P=0.193N     P=0.617N     P=0.418N     P=0.255N    |P=0.151N     P=0.675N     P=0.685N     P=0.226N     | 
|POLY 6             |     P=0.232N     P=0.600N     P=0.505N     P=0.294N    |P=0.148N     P=0.665N     P=0.682      P=0.222N     | 
|LOGISTIC REGRESSION|     P=0.179N     P=0.579      P=0.365N     P=0.243N    |P=0.153N     P=0.685N     P=0.689N     (e)          | 
|COCH-ARM / FISHERS |     P=0.180N     P=0.606      P=0.383N     P=0.243N    |P=0.153N     P=0.691N     P=0.684N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.273N     (e)          (e)          (e)         |P=0.176N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   10/49 (20%)  11/49 (22%)  4/50 (8%)   |4/49 (8%)    2/49 (4%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/43.45      10/44.34     11/40.21     4/40.90     |4/42.86      2/45.60      5/43.14      0/45.19      | 
|POLY-3 PERCENT (g) |     13.8%        22.6%        27.4%        9.8%        |9.3%         4.4%         11.6%        0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    5/29 (17%)   2/16 (13%)   2/22 (9%)   |3/33 (9%)    2/34 (6%)    3/28 (11%)   0/36 (0%)    | 
|FIRST INCIDENCE    |     539          591          509          696         |642          730 (T)      509          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200N     P=0.255      P=0.064      P=0.456N    |P=0.067N     P=0.314N     P=0.431      P=0.055N     | 
|POLY 3             |     P=0.148N     P=0.216      P=0.100      P=0.407N    |P=0.069N     P=0.309N     P=0.504      P=0.054N     | 
|POLY 1.5           |     P=0.129N     P=0.209      P=0.115      P=0.388N    |P=0.069N     P=0.315N     P=0.516      P=0.054N     | 
|POLY 6             |     P=0.187N     P=0.224      P=0.080      P=0.443N    |P=0.069N     P=0.306N     P=0.481      P=0.053N     | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.177      P=0.159      P=0.370N    |P=0.071N     P=0.306N     P=0.513      P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.194      P=0.133      P=0.370N    |P=0.071N     P=0.339N     P=0.513      P=0.056N     | 
|ORDER RESTRICTED   |     P=0.135N     (e)          (e)          (e)         |P=0.049N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    4/50 (8%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/42.90      0/36.82      4/41.05     |0/42.54      0/45.60      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         9.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    3/22 (14%)  |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          635         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.045 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          (e)          P=0.057     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          (e)          P=0.054     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.002 **   (e)          (e)          P=0.055     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.002 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.002 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    7/49 (14%)   15/50 (30%) |0/49 (0%)    0/49 (0%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/41.77      2/42.90      7/37.35      15/43.59    |0/42.54      0/45.60      0/42.02      4/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.7%         18.7%        34.4%       |0.0%         0.0%         0.0%         8.9%         | 
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    4/16 (25%)   5/22 (23%)  |0/33 (0%)    0/34 (0%)    0/28 (0%)    4/36 (11%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      656          518         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.525      P=0.006 **   P<0.001 **  |P=0.003 **   (e)          (e)          P=0.074      | 
|POLY 3             |     P<0.001 **   P=0.509      P=0.019 *    P<0.001 **  |P=0.002 **   (e)          (e)          P=0.068      | 
|POLY 1.5           |     P<0.001 **   P=0.504      P=0.023 *    P<0.001 **  |P=0.002 **   (e)          (e)          P=0.067      | 
|POLY 6             |     P<0.001 **   P=0.516      P=0.013 *    P<0.001 **  |P=0.002 **   (e)          (e)          P=0.069      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.525      P=0.010 *    P<0.001 **  |(e)          (e)          (e)          P=0.074      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.492      P=0.028 *    P<0.001 **  |P=0.002 **   (e)          (e)          P=0.061      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    2/49 (4%)    15/50 (30%) |0/49 (0%)    0/49 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/42.12      1/42.90      2/37.58      15/42.99    |0/42.54      0/45.60      0/42.02      3/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         5.3%         34.9%       |0.0%         0.0%         0.0%         6.6%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    7/22 (32%)  |0/33 (0%)    0/34 (0%)    0/28 (0%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     631          729 (T)      565          509         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.750N     P=0.434      P<0.001 **  |P=0.012 *    (e)          (e)          P=0.136      | 
|POLY 3             |     P<0.001 **   P=0.757N     P=0.460      P<0.001 **  |P=0.008 **   (e)          (e)          P=0.130      | 
|POLY 1.5           |     P<0.001 **   P=0.759N     P=0.476      P<0.001 **  |P=0.008 **   (e)          (e)          P=0.128      | 
|POLY 6             |     P<0.001 **   P=0.754N     P=0.435      P<0.001 **  |P=0.008 **   (e)          (e)          P=0.131      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.757      P=0.518      P<0.001 **  |(e)          (e)          (e)          P=0.136      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.747      P=0.492      P<0.001 **  |P=0.009 **   (e)          (e)          P=0.125      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.010 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/49 (0%)    1/50 (2%)   |1/49 (2%)    1/49 (2%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/42.90      0/36.82      1/40.72     |1/42.54      1/45.60      4/42.44      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         2.5%        |2.4%         2.2%         9.4%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    1/22 (5%)   |1/33 (3%)    1/34 (3%)    3/28 (11%)   1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |730 (T)      730 (T)      610          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.432      P=0.514      (e)          P=0.459     |P=0.516N     P=0.755N     P=0.143      P=0.742N     | 
|POLY 3             |     P=0.476      P=0.505      (e)          P=0.495     |P=0.542N     P=0.745N     P=0.177      P=0.747N     | 
|POLY 1.5           |     P=0.479      P=0.502      (e)          P=0.498     |P=0.542N     P=0.749N     P=0.184      P=0.749N     | 
|POLY 6             |     P=0.469      P=0.509      (e)          P=0.488     |P=0.542N     P=0.742N     P=0.165      P=0.746N     | 
|LOGISTIC REGRESSION|     (e)          P=0.514      (e)          P=0.459     |P=0.538N     P=0.755N     P=0.173      P=0.742N     | 
|COCH-ARM / FISHERS |     P=0.480      P=0.495      (e)          P=0.500     |P=0.546N     P=0.753N     P=0.187      P=0.747N     | 
|ORDER RESTRICTED   |     P=0.246      (e)          (e)          (e)         |P=0.325      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    25/49 (51%)  45/49 (92%)  50/50 (100%)|10/49 (20%)  22/49 (45%)  48/50 (96%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     0/41.77      25/45.91     45/47.80     50/50.00    |10/44.00     22/47.76     48/49.87     50/50.00     | 
|POLY-3 PERCENT (g) |     0.0%         54.5%        94.2%        100.0%      |22.7%        46.1%        96.2%        100.0%       | 
|TERMINAL (d)       |     0/27 (0%)    17/29 (59%)  16/16 (100%) 22/22 (100%)|6/33 (18%)   15/34 (44%)  27/28 (96%)  36/36 (100%) | 
|FIRST INCIDENCE    |     ---          464          361          254         |380          410          471          283          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    4/49 (8%)    3/50 (6%)   |2/49 (4%)    1/49 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.55      2/43.28      4/37.88      3/40.77     |2/42.86      1/45.60      1/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     4.7%         4.6%         10.6%        7.4%        |4.7%         2.2%         2.4%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    2/22 (9%)   |1/33 (3%)    1/34 (3%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     604          621          619          716         |642          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400      P=0.685N     P=0.242      P=0.444     |P=0.491N     P=0.475N     P=0.547N     P=0.472N     | 
|POLY 3             |     P=0.425      P=0.688N     P=0.284      P=0.480     |P=0.513N     P=0.478N     P=0.507N     P=0.482N     | 
|POLY 1.5           |     P=0.443      P=0.692N     P=0.305      P=0.491     |P=0.514N     P=0.483N     P=0.496N     P=0.483N     | 
|POLY 6             |     P=0.393      P=0.684N     P=0.254      P=0.460     |P=0.510N     P=0.476N     P=0.525N     P=0.481N     | 
|LOGISTIC REGRESSION|     P=0.463      P=0.653      P=0.348      P=0.497     |P=0.508N     P=0.493N     P=0.500N     P=0.486N     | 
|COCH-ARM / FISHERS |     P=0.462      P=0.684      P=0.329      P=0.500     |P=0.514N     P=0.500N     P=0.492N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.347      (e)          (e)          (e)         |P=0.391N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   5/50 (10%)   3/50 (6%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |                                                        |6/42.73      5/47.04      3/42.33      8/45.24      | 
|POLY-3 PERCENT (g) |                                                        |14.0%        10.6%        7.1%         17.7%        | 
|TERMINAL (d)       |                                                        |6/33 (18%)   2/34 (6%)    2/28 (7%)    6/36 (17%)   | 
|FIRST INCIDENCE    |                                                        |730 (T)      642          646          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.268      P=0.458N     P=0.321N     P=0.460      | 
|POLY 3             |                                                        |P=0.209      P=0.433N     P=0.245N     P=0.431      | 
|POLY 1.5           |                                                        |P=0.207      P=0.452N     P=0.237N     P=0.420      | 
|POLY 6             |                                                        |P=0.211      P=0.417N     P=0.262N     P=0.440      | 
|LOGISTIC REGRESSION|                                                        |P=0.225      P=0.443N     P=0.284N     P=0.461      | 
|COCH-ARM / FISHERS |                                                        |P=0.203      P=0.500N     P=0.243N     P=0.387      | 
|ORDER RESTRICTED   |                                                        |P=0.250      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/49 (2%)    0/50 (0%)   |4/49 (8%)    4/50 (8%)    1/50 (2%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/41.77      3/43.38      1/37.13      0/40.72     |4/42.54      4/46.42      1/42.14      4/45.31      | 
|POLY-3 PERCENT (g) |     2.4%         6.9%         2.7%         0.0%        |9.4%         8.6%         2.4%         8.8%         | 
|TERMINAL (d)       |     1/27 (4%)    3/29 (10%)   0/16 (0%)    0/22 (0%)   |4/33 (12%)   4/34 (12%)   0/28 (0%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      646          ---         |730 (T)      730 (T)      698          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.215N     P=0.330      P=0.678      P=0.541N    |P=0.593      P=0.629N     P=0.230N     P=0.598N     | 
|POLY 3             |     P=0.174N     P=0.318      P=0.734      P=0.505N    |P=0.558      P=0.595N     P=0.181N     P=0.608N     | 
|POLY 1.5           |     P=0.173N     P=0.315      P=0.745      P=0.502N    |P=0.550      P=0.604N     P=0.174N     P=0.616N     | 
|POLY 6             |     P=0.179N     P=0.323      P=0.716      P=0.512N    |P=0.567      P=0.590N     P=0.193N     P=0.602N     | 
|LOGISTIC REGRESSION|     P=0.194N     P=0.330      P=0.741      (e)         |P=0.570      P=0.629N     P=0.211N     P=0.604N     | 
|COCH-ARM / FISHERS |     P=0.173N     P=0.309      P=0.747      P=0.500N    |P=0.534      P=0.631N     P=0.175N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.165N     (e)          (e)          (e)         |P=0.404N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/49 (4%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/42.36      1/43.90      2/36.95      0/40.72     |1/42.72      0/46.42      1/42.02      0/45.13      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         5.4%         0.0%        |2.3%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     539          569          696          ---         |684          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345N     P=0.758N     P=0.396      P=0.500N    |P=0.461N     P=0.495N     P=0.727      P=0.490N     | 
|POLY 3             |     P=0.334N     P=0.753N     P=0.452      P=0.508N    |P=0.480N     P=0.483N     P=0.757      P=0.489N     | 
|POLY 1.5           |     P=0.326N     P=0.755N     P=0.472      P=0.504N    |P=0.480N     P=0.486N     P=0.758N     P=0.491N     | 
|POLY 6             |     P=0.349N     P=0.750N     P=0.422      P=0.516N    |P=0.478N     P=0.482N     P=0.746      P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.677      P=0.501      P=0.498N    |P=0.474N     P=0.504N     P=0.760      P=0.507N     | 
|COCH-ARM / FISHERS |     P=0.317N     P=0.753N     P=0.492      P=0.500N    |P=0.480N     P=0.495N     P=0.747N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.267N     (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    4/49 (8%)    2/50 (4%)   |3/49 (6%)    6/50 (12%)   3/50 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     5/42.58      2/43.69      4/37.66      2/40.72     |3/43.02      6/46.74      3/42.67      3/45.13      | 
|POLY-3 PERCENT (g) |     11.7%        4.6%         10.6%        4.9%        |7.0%         12.8%        7.0%         6.7%         | 
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    2/16 (13%)   2/22 (9%)   |2/33 (6%)    5/34 (15%)   1/28 (4%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     604          642          509          729 (T)     |587          642          593          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.373N     P=0.202N     P=0.554      P=0.291N    |P=0.347N     P=0.271      P=0.612      P=0.627N     | 
|POLY 3             |     P=0.317N     P=0.205N     P=0.577N     P=0.233N    |P=0.370N     P=0.284      P=0.659      P=0.640N     | 
|POLY 1.5           |     P=0.304N     P=0.208N     P=0.545N     P=0.224N    |P=0.376N     P=0.277      P=0.655N     P=0.644N     | 
|POLY 6             |     P=0.342N     P=0.202N     P=0.629N     P=0.253N    |P=0.366N     P=0.288      P=0.641      P=0.640N     | 
|LOGISTIC REGRESSION|     P=0.297N     P=0.215N     P=0.534N     P=0.226N    |P=0.383N     P=0.267      P=0.655N     P=0.647N     | 
|COCH-ARM / FISHERS |     P=0.290N     P=0.218N     P=0.513N     P=0.218N    |P=0.394N     P=0.254      P=0.651N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.191N     (e)          (e)          (e)         |P=0.451N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   2/50 (4%)    3/49 (6%)    7/50 (14%)  |15/50 (30%)  10/50 (20%)  11/49 (22%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     6/42.17      2/43.38      3/37.14      7/41.54     |15/43.75     10/46.43     11/41.56     17/45.99     | 
|POLY-3 PERCENT (g) |     14.2%        4.6%         8.1%         16.9%       |34.3%        21.5%        26.5%        37.0%        | 
|TERMINAL (d)       |     3/27 (11%)   2/29 (7%)    1/16 (6%)    4/22 (18%)  |11/33 (33%)  9/34 (27%)   9/28 (32%)   15/36 (42%)  | 
|FIRST INCIDENCE    |     458          729 (T)      656          550         |587          726          634          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109      P=0.119N     P=0.464N     P=0.394     |P=0.238      P=0.150N     P=0.406N     P=0.527      | 
|POLY 3             |     P=0.153      P=0.122N     P=0.307N     P=0.488     |P=0.162      P=0.130N     P=0.290N     P=0.482      | 
|POLY 1.5           |     P=0.160      P=0.123N     P=0.275N     P=0.503     |P=0.157      P=0.139N     P=0.265N     P=0.468      | 
|POLY 6             |     P=0.140      P=0.123N     P=0.359N     P=0.460     |P=0.170      P=0.131N     P=0.342N     P=0.487      | 
|LOGISTIC REGRESSION|     P=0.157      P=0.127N     P=0.264N     P=0.511     |P=0.176      P=0.113N     P=0.311N     P=0.489      | 
|COCH-ARM / FISHERS |     P=0.168      P=0.128N     P=0.243N     P=0.516     |P=0.149      P=0.178N     P=0.266N     P=0.415      | 
|ORDER RESTRICTED   |     P=0.187      (e)          (e)          (e)         |P=0.247      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura: Mesothelium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.04      0/43.38      0/36.82      2/40.72     |0/42.73      0/46.42      0/41.14      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    (e)          (e)          P=0.194     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.227     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.194     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/49 (6%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/42.26      3/43.38      3/38.13      0/40.72     |                                                    | 
|POLY-3 PERCENT (g) |     4.7%         6.9%         7.9%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/27 (0%)    3/29 (10%)   0/16 (0%)    0/22 (0%)   |                                                    | 
|FIRST INCIDENCE    |     642          729 (T)      361          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.155N     P=0.536      P=0.409      P=0.263N    |                                                    | 
|POLY 3             |     P=0.127N     P=0.512      P=0.453      P=0.245N    |                                                    | 
|POLY 1.5           |     P=0.122N     P=0.509      P=0.473      P=0.241N    |                                                    | 
|POLY 6             |     P=0.137N     P=0.513      P=0.419      P=0.255N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.113N     P=0.516      P=0.529      P=0.237N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.500      P=0.490      P=0.247N    |                                                    | 
|ORDER RESTRICTED   |     P=0.131N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    4/49 (8%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     4/42.40      0/43.38      4/37.28      0/40.72     |                                                    | 
|POLY-3 PERCENT (g) |     9.4%         0.0%         10.7%        0.0%        |                                                    | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    1/16 (6%)    0/22 (0%)   |                                                    | 
|FIRST INCIDENCE    |     655          ---          656          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170N     P=0.057N     P=0.440      P=0.084N    |                                                    | 
|POLY 3             |     P=0.141N     P=0.057N     P=0.571      P=0.065N    |                                                    | 
|POLY 1.5           |     P=0.134N     P=0.058N     P=0.602      P=0.062N    |                                                    | 
|POLY 6             |     P=0.154N     P=0.057N     P=0.522      P=0.071N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.136N     P=0.061N     P=0.565      P=0.064N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.129N     P=0.059N     P=0.631      P=0.059N    |                                                    | 
|ORDER RESTRICTED   |     P=0.028N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  24/50 (48%)  27/49 (55%)  27/50 (54%) |                                                    | 
|POLY-3 RATE (b)    |     31/46.04     24/45.85     27/43.15     27/45.25    |                                                    | 
|POLY-3 PERCENT (g) |     67.3%        52.4%        62.6%        59.7%       |                                                    | 
|TERMINAL (d)       |     16/27 (59%)  15/29 (52%)  9/16 (56%)   10/22 (46%) |                                                    | 
|FIRST INCIDENCE    |     465          509          431          509         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.344      P=0.097N     P=0.207      P=0.550N    |                                                    | 
|POLY 3             |     P=0.501N     P=0.098N     P=0.398N     P=0.288N    |                                                    | 
|POLY 1.5           |     P=0.492N     P=0.097N     P=0.346N     P=0.275N    |                                                    | 
|POLY 6             |     P=0.516N     P=0.112N     P=0.498N     P=0.322N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.497N     P=0.091N     P=0.374N     P=0.282N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.114N     P=0.311N     P=0.272N    |                                                    | 
|ORDER RESTRICTED   |     P=0.276N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   3/49 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/41.77      5/43.53      3/37.41      1/40.72     |0/42.73      1/46.42      1/42.57      0/45.19      | 
|POLY-3 PERCENT (g) |     7.2%         11.5%        8.0%         2.5%        |0.0%         2.2%         2.4%         0.0%         | 
|TERMINAL (d)       |     3/27 (11%)   4/29 (14%)   1/16 (6%)    1/22 (5%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      689          561          729 (T)     |---          730 (T)      559          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194N     P=0.401      P=0.450      P=0.379N    |P=0.511N     P=0.506      P=0.504      (e)          | 
|POLY 3             |     P=0.137N     P=0.379      P=0.611      P=0.314N    |P=0.508N     P=0.517      P=0.499      (e)          | 
|POLY 1.5           |     P=0.134N     P=0.372      P=0.632      P=0.309N    |P=0.512N     P=0.512      P=0.502      (e)          | 
|POLY 6             |     P=0.147N     P=0.388      P=0.577      P=0.325N    |P=0.505N     P=0.519      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.155N     P=0.399      P=0.580      P=0.379N    |P=0.538N     P=0.506      P=0.432      (e)          | 
|COCH-ARM / FISHERS |     P=0.131N     P=0.357      P=0.651      P=0.309N    |P=0.522N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.174N     (e)          (e)          (e)         |P=0.400N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    6/49 (12%)   1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/41.84      1/43.38      6/36.90      1/40.72     |0/42.73      0/46.42      1/42.14      0/45.19      | 
|POLY-3 PERCENT (g) |     7.2%         2.3%         16.3%        2.5%        |0.0%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    5/16 (31%)   1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     712          729 (T)      709          729 (T)     |---          ---          698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.284N     P=0.061      P=0.382N    |P=0.761N     (e)          P=0.477      (e)          | 
|POLY 3             |     P=0.327N     P=0.292N     P=0.181      P=0.314N    |P=0.770N     (e)          P=0.497      (e)          | 
|POLY 1.5           |     P=0.313N     P=0.296N     P=0.206      P=0.309N    |P=0.770N     (e)          P=0.501      (e)          | 
|POLY 6             |     P=0.353N     P=0.287N     P=0.145      P=0.326N    |P=0.769N     (e)          P=0.490      (e)          | 
|LOGISTIC REGRESSION|     P=0.379N     P=0.275N     P=0.078      P=0.357N    |P=0.771N     (e)          P=0.499      (e)          | 
|COCH-ARM / FISHERS |     P=0.300N     P=0.309N     P=0.233      P=0.309N    |P=0.772N     (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.229N     (e)          (e)          (e)         |P=0.379      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      2/41.01     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          648         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.039 *    (e)          (e)          P=0.217     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.233     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.227     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.042 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.028 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      0/36.82      2/41.29     |1/43.05      0/46.42      0/42.02      1/45.51      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         4.8%        |2.3%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          648         |642          ---          ---          642          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164      P=0.486N     P=0.604N     P=0.470     |P=0.525      P=0.469N     P=0.515N     P=0.746N     | 
|POLY 3             |     P=0.171      P=0.492N     P=0.525N     P=0.496     |P=0.520      P=0.485N     P=0.505N     P=0.748N     | 
|POLY 1.5           |     P=0.173      P=0.495N     P=0.515N     P=0.499     |P=0.520      P=0.488N     P=0.500N     P=0.751N     | 
|POLY 6             |     P=0.167      P=0.490N     P=0.542N     P=0.489     |P=0.522      P=0.484N     P=0.514N     P=0.746N     | 
|LOGISTIC REGRESSION|     P=0.175      (e)          (e)          P=0.499     |P=0.507      P=0.541N     P=0.512N     P=0.743      | 
|COCH-ARM / FISHERS |     P=0.176      P=0.500N     P=0.505N     P=0.500     |P=0.522      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.130      (e)          (e)          (e)         |P=0.385N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/49 (8%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.22      3/43.51      4/38.47      1/40.72     |1/42.86      2/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.7%         6.9%         10.4%        2.5%        |2.3%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    2/34 (6%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     656          697          431          729 (T)     |642          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.344N     P=0.544      P=0.253      P=0.538N    |P=0.232N     P=0.525      P=0.515N     P=0.486N     | 
|POLY 3             |     P=0.300N     P=0.514      P=0.294      P=0.513N    |P=0.228N     P=0.528      P=0.504N     P=0.489N     | 
|POLY 1.5           |     P=0.289N     P=0.510      P=0.312      P=0.506N    |P=0.232N     P=0.523      P=0.498N     P=0.490N     | 
|POLY 6             |     P=0.322N     P=0.517      P=0.264      P=0.528N    |P=0.224N     P=0.529      P=0.514N     P=0.489N     | 
|LOGISTIC REGRESSION|     P=0.272N     P=0.513      P=0.363      P=0.505N    |P=0.237N     P=0.514      P=0.506N     P=0.515N     | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.500      P=0.329      P=0.500N    |P=0.238N     P=0.508      P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.172N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    7/49 (14%)   4/50 (8%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/42.15      1/43.38      7/38.20      4/40.87     |0/42.54      0/46.42      0/42.02      2/45.21      | 
|POLY-3 PERCENT (g) |     11.9%        2.3%         18.3%        9.8%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     3/27 (11%)   1/29 (3%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     642          729 (T)      611          696         |---          ---          ---          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434      P=0.092N     P=0.166      P=0.606N    |P=0.055      (e)          (e)          P=0.262      | 
|POLY 3             |     P=0.498      P=0.094N     P=0.309      P=0.520N    |P=0.042 *    (e)          (e)          P=0.251      | 
|POLY 1.5           |     P=0.516      P=0.096N     P=0.336      P=0.508N    |P=0.042 *    (e)          (e)          P=0.249      | 
|POLY 6             |     P=0.464      P=0.092N     P=0.270      P=0.543N    |P=0.043 *    (e)          (e)          P=0.252      | 
|LOGISTIC REGRESSION|     P=0.510      P=0.091N     P=0.297      P=0.552N    |P=0.051      (e)          (e)          P=0.256      | 
|COCH-ARM / FISHERS |     P=0.537      P=0.102N     P=0.365      P=0.500N    |P=0.043 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |     P=0.234      (e)          (e)          (e)         |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    3/50 (6%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.70      0/43.38      1/37.13      3/41.72     |1/42.54      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.7%         7.2%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     296          ---          646          582         |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079      P=0.500N     P=0.736      P=0.294     |P=0.529N     P=0.494N     P=0.533N     P=0.483N     | 
|POLY 3             |     P=0.076      P=0.497N     P=0.729      P=0.296     |P=0.550N     P=0.483N     P=0.502N     P=0.488N     | 
|POLY 1.5           |     P=0.078      P=0.498N     P=0.741      P=0.300     |P=0.550N     P=0.486N     P=0.497N     P=0.490N     | 
|POLY 6             |     P=0.073      P=0.495N     P=0.710      P=0.290     |P=0.548N     P=0.481N     P=0.512N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.089      (e)          P=0.754      P=0.289     |P=0.529N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.081      P=0.500N     P=0.747      P=0.309     |P=0.545N     P=0.495N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |P=0.109N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    5/49 (10%)   1/50 (2%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/42.20      2/43.46      5/39.08      1/40.77     |0/42.54      1/46.60      0/42.02      3/46.32      | 
|POLY-3 PERCENT (g) |     2.4%         4.6%         12.8%        2.5%        |0.0%         2.2%         0.0%         6.5%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     604          709          509          716         |---          684          ---          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.468N     P=0.513      P=0.083      P=0.739     |P=0.049 *    P=0.505      (e)          P=0.136      | 
|POLY 3             |     P=0.459N     P=0.510      P=0.083      P=0.753     |P=0.045 *    P=0.518      (e)          P=0.135      | 
|POLY 1.5           |     P=0.444N     P=0.507      P=0.090      P=0.757     |P=0.043 *    P=0.515      (e)          P=0.131      | 
|POLY 6             |     P=0.485N     P=0.513      P=0.073      P=0.745     |P=0.047 *    P=0.521      (e)          P=0.138      | 
|LOGISTIC REGRESSION|     P=0.413N     P=0.499      P=0.115      P=0.761N    |P=0.034 *    P=0.496      (e)          P=0.090      | 
|COCH-ARM / FISHERS |     P=0.430N     P=0.500      P=0.098      P=0.753N    |P=0.042 *    P=0.505      (e)          P=0.125      | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/49 (4%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/42.47      1/43.38      2/37.61      4/42.11     |0/42.54      0/46.42      0/42.02      0/45.13      | 
|POLY-3 PERCENT (g) |     4.7%         2.3%         5.3%         9.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     604          729 (T)      537          550         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      P=0.488N     P=0.621      P=0.331     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.142      P=0.493N     P=0.650      P=0.332     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.145      P=0.494N     P=0.668      P=0.336     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.137      P=0.493N     P=0.619      P=0.323     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.154      P=0.516N     P=0.677N     P=0.339     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.147      P=0.500N     P=0.684      P=0.339     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.169      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/49 (6%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    4/50 (8%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/43.20      0/43.38      3/37.43      4/42.28     |0/42.54      0/46.42      4/42.93      0/45.13      | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         8.0%         9.5%        |0.0%         0.0%         9.3%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     296          ---          646          550         |---          ---          528          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173      P=0.124N     P=0.536      P=0.477     |P=0.510N     (e)          P=0.054      (e)          | 
|POLY 3             |     P=0.179      P=0.118N     P=0.595      P=0.488     |P=0.524N     (e)          P=0.061      (e)          | 
|POLY 1.5           |     P=0.182      P=0.118N     P=0.621      P=0.493     |P=0.525N     (e)          P=0.064      (e)          | 
|POLY 6             |     P=0.172      P=0.117N     P=0.556      P=0.479     |P=0.525N     (e)          P=0.057      (e)          | 
|LOGISTIC REGRESSION|     P=0.201      P=0.195N     P=0.634N     P=0.494     |P=0.569N     (e)          P=0.063      (e)          | 
|COCH-ARM / FISHERS |     P=0.188      P=0.121N     P=0.651      P=0.500     |P=0.535N     (e)          P=0.061      (e)          | 
|ORDER RESTRICTED   |     P=0.183      (e)          (e)          (e)         |P=0.110      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/49 (6%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      3/37.59      0/40.72     |0/42.54      0/46.42      0/42.02      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          509          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.610N     (e)          P=0.075      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.605N     (e)          P=0.100      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.594N     (e)          P=0.107      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.625N     (e)          P=0.089      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.574N     (e)          P=0.123      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.580N     (e)          P=0.117      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  19/50 (38%)  18/49 (37%)  20/50 (40%) |                                                    | 
|POLY-3 RATE (b)    |     20/44.56     19/46.37     18/40.71     20/43.92    |                                                    | 
|POLY-3 PERCENT (g) |     44.9%        41.0%        44.2%        45.5%       |                                                    | 
|TERMINAL (d)       |     9/27 (33%)   10/29 (35%)  4/16 (25%)   7/22 (32%)  |                                                    | 
|FIRST INCIDENCE    |     625          509          509          550         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.411N     P=0.252      P=0.398     |                                                    | 
|POLY 3             |     P=0.449      P=0.434N     P=0.563N     P=0.561     |                                                    | 
|POLY 1.5           |     P=0.471      P=0.450N     P=0.503N     P=0.576     |                                                    | 
|POLY 6             |     P=0.412      P=0.435N     P=0.520      P=0.524     |                                                    | 
|LOGISTIC REGRESSION|     P=0.481      P=0.489N     P=0.525N     P=0.566     |                                                    | 
|COCH-ARM / FISHERS |     P=0.498      P=0.500N     P=0.449N     P=0.581N    |                                                    | 
|ORDER RESTRICTED   |     P=0.620      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    8/49 (16%)   8/50 (16%)  |                                                    | 
|POLY-3 RATE (b)    |     4/41.79      3/43.96      8/39.07      8/42.23     |                                                    | 
|POLY-3 PERCENT (g) |     9.6%         6.8%         20.5%        18.9%       |                                                    | 
|TERMINAL (d)       |     3/27 (11%)   1/29 (3%)    1/16 (6%)    3/22 (14%)  |                                                    | 
|FIRST INCIDENCE    |     723          642          509          550         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076      P=0.459N     P=0.065      P=0.126     |                                                    | 
|POLY 3             |     P=0.095      P=0.472N     P=0.141      P=0.179     |                                                    | 
|POLY 1.5           |     P=0.099      P=0.482N     P=0.154      P=0.180     |                                                    | 
|POLY 6             |     P=0.087      P=0.459N     P=0.123      P=0.174     |                                                    | 
|LOGISTIC REGRESSION|     P=0.104      P=0.478N     P=0.152      P=0.168     |                                                    | 
|COCH-ARM / FISHERS |     P=0.105      P=0.500N     P=0.168      P=0.178     |                                                    | 
|ORDER RESTRICTED   |     P=0.092      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/50 (8%)    7/49 (14%)   7/50 (14%)  |9/49 (18%)   8/50 (16%)   7/50 (14%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     8/42.18      4/43.69      7/38.44      7/41.55     |9/43.24      8/47.24      7/42.33      5/45.83      | 
|POLY-3 PERCENT (g) |     19.0%        9.2%         18.2%        16.9%       |20.8%        16.9%        16.5%        10.9%        | 
|TERMINAL (d)       |     6/27 (22%)   3/29 (10%)   2/16 (13%)   4/22 (18%)  |7/33 (21%)   5/34 (15%)   6/28 (21%)   4/36 (11%)   | 
|FIRST INCIDENCE    |     625          642          565          639         |625          621          646          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355      P=0.151N     P=0.397      P=0.581     |P=0.136N     P=0.451N     P=0.517N     P=0.155N     | 
|POLY 3             |     P=0.455      P=0.158N     P=0.579N     P=0.513N    |P=0.155N     P=0.420N     P=0.409N     P=0.160N     | 
|POLY 1.5           |     P=0.467      P=0.164N     P=0.548N     P=0.505N    |P=0.158N     P=0.435N     P=0.384N     P=0.164N     | 
|POLY 6             |     P=0.430      P=0.150N     P=0.604      P=0.532N    |P=0.152N     P=0.410N     P=0.453N     P=0.158N     | 
|LOGISTIC REGRESSION|     P=0.455      P=0.152N     P=0.607N     P=0.545N    |P=0.158N     P=0.449N     P=0.425N     P=0.171N     | 
|COCH-ARM / FISHERS |     P=0.482      P=0.178N     P=0.517N     P=0.500N    |P=0.165N     P=0.482N     P=0.376N     P=0.183N     | 
|ORDER RESTRICTED   |     P=0.455N     (e)          (e)          (e)         |P=0.159N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   0/0 (0%)     3/3 (100%)   1/1 (100%)  |1/2 (50%)    0/0 (0%)     0/0 (0%)     0/1 (0%)     | 
|POLY-3 RATE (b)    |     2/2.00       0/0.00       3/3.00       1/1.00      |1/2.00       0/0.00       0/0.00       0/0.97       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       100.0%      |50.0%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/2 (100%)   0/0 (0%)     1/1 (100%)   1/1 (100%)  |1/2 (50%)    0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          537          729 (T)     |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=1.000      P=1.000      P=1.000      P=1.000      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.618N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.616N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.623N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=1.000      (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.543N     P=1.000      P=1.000      P=0.667N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urethra: Transitional Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     1/1 (100%)   2/2 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       0/0.00       1/1.00       2/2.00      |0/0.00       0/0.00       0/0.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       100.0%      |0.0%         0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     0/0 (0%)     1/1 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          722          724         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/04/03                           EXPERIMENT: 90004 TEST: 07                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            PROPYLENE GLYCOL MONO-T-BUTYL ET            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    3/49 (6%)    6/50 (12%)  |1/49 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/42.22      1/42.90      3/37.80      6/41.77     |1/42.71      1/46.62      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     7.1%         2.3%         7.9%         14.4%       |2.3%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     656          729 (T)      565          582         |687          676          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.278N     P=0.517      P=0.201     |P=0.346N     P=0.747N     P=0.522N     P=0.495N     | 
|POLY 3             |     P=0.055      P=0.299N     P=0.611      P=0.235     |P=0.341N     P=0.741N     P=0.503N     P=0.489N     | 
|POLY 1.5           |     P=0.058      P=0.303N     P=0.632      P=0.240     |P=0.344N     P=0.744N     P=0.498N     P=0.490N     | 
|POLY 6             |     P=0.050      P=0.296N     P=0.576      P=0.222     |P=0.337N     P=0.739N     P=0.513N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.061      P=0.299N     P=0.659      P=0.239     |P=0.348N     P=0.761      P=0.496N     P=0.497N     | 
|COCH-ARM / FISHERS |     P=0.062      P=0.316N     P=0.651      P=0.243     |P=0.346N     P=0.747N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.071      (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/42.73      0/46.42      1/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         2.4%         4.4%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    0/34 (0%)    1/28 (4%)    2/36 (6%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.118      (e)          P=0.467      P=0.258      | 
|POLY 3             |                                                        |P=0.099      (e)          P=0.497      P=0.250      | 
|POLY 1.5           |                                                        |P=0.099      (e)          P=0.501      P=0.247      | 
|POLY 6             |                                                        |P=0.099      (e)          P=0.488      P=0.252      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.467      P=0.258      | 
|COCH-ARM / FISHERS |                                                        |P=0.097      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |                                                        |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).