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https://ntp.niehs.nih.gov/go/13014

Oleic Acid Diethanolamine Condensate

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                                                                           TIME: 13:27:08

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  C91014

       CONTRACT NUMBER:  NO1-ES-15314

       CAS NUMBER:  93-83-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

155         155  470 09/01/94   498 09/29/94   2/18  Irritation Site of Applic

168         168  330 04/14/94   722 05/11/95  15/26  Irritation Site of Applic

169         169  666 03/16/95   666 03/16/95   1/24  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 50 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

201         201  189 11/24/93   274 02/17/94   4/10  Irritation Site of Applic

202         202  162 10/28/93   386 06/09/94   7/14  Irritation Site of Applic

203         203  189 11/24/93   722 05/11/95  20/26  Irritation Site of Applic

204         204  722 05/11/95   722 05/11/95   1/26  Irritation Site of Applic

206         206  189 11/24/93   722 05/11/95  15/26  Irritation Site of Applic

207         207  162 10/28/93   526 10/27/94  13/19  Irritation Site of Applic

208         208  274 02/17/94   526 10/27/94   9/19  Irritation Site of Applic

209         209  218 12/23/93   526 10/27/94  12/19  Irritation Site of Applic

210         210  246 01/20/94   722 05/11/95  18/26  Irritation Site of Applic

211         211  162 10/28/93   666 03/16/95  19/24  Irritation Site of Applic

212         212  162 10/28/93   610 01/19/95  17/22  Irritation Site of Applic

213         213  189 11/24/93   666 03/16/95  18/24  Irritation Site of Applic

214         214  189 11/24/93   722 05/11/95  16/26  Irritation Site of Applic

215         215  162 10/28/93   666 03/16/95  14/26  Irritation Site of Applic

216         216  134 09/30/93   694 04/13/95  16/26  Irritation Site of Applic

217         217  162 10/28/93   722 05/11/95  12/26  Irritation Site of Applic

218         218  162 10/28/93   638 02/16/95  16/23  Irritation Site of Applic

219         219  162 10/28/93   666 03/16/95  17/24  Irritation Site of Applic

220         220  246 01/20/94   386 06/09/94   5/26  Irritation Site of Applic

221         221  162 10/28/93   722 05/11/95  20/26  Irritation Site of Applic

222         222  246 01/20/94   553 11/23/94   6/20  Irritation Site of Applic

223         223  218 12/23/93   274 02/17/94   2/13  Irritation Site of Applic

225         225  162 10/28/93   330 04/14/94   2/19  Irritation Site of Applic

226         226  162 10/28/93   330 04/14/94   4/20  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 50 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

227         227  582 12/22/94   722 05/11/95   5/26  Irritation Site of Applic

228         228  218 12/23/93   638 02/16/95  10/24  Irritation Site of Applic

229         229  274 02/17/94   498 09/29/94   9/18  Irritation Site of Applic

230         230  246 01/20/94   330 04/14/94   4/26  Irritation Site of Applic

231         231  218 12/23/93   218 12/23/93   1/8   Irritation Site of Applic

232         232  218 12/23/93   246 01/20/94   2/9   Irritation Site of Applic

233         233  189 11/24/93   694 04/13/95  19/25  Irritation Site of Applic

234         234  162 10/28/93   722 05/11/95  18/26  Irritation Site of Applic

236         236  162 10/28/93   526 10/27/94  13/19  Irritation Site of Applic

238         238  246 01/20/94   722 05/11/95   4/26  Irritation Site of Applic

239         239  218 12/23/93   358 05/12/94   4/19  Irritation Site of Applic

240         240  189 11/24/93   386 06/09/94   6/19  Irritation Site of Applic

241         241  246 01/20/94   610 01/19/95   5/24  Irritation Site of Applic

242         242  358 05/12/94   722 05/11/95   5/26  Irritation Site of Applic

243         243  246 01/20/94   358 05/12/94   4/26  Irritation Site of Applic

244         244  274 02/17/94   638 02/16/95  11/23  Irritation Site of Applic

245         245  218 12/23/93   722 05/11/95  16/26  Irritation Site of Applic

246         246  189 11/24/93   722 05/11/95   9/26  Irritation Site of Applic

247         247  189 11/24/93   414 07/07/94   9/15  Irritation Site of Applic

248         248  189 11/24/93   274 02/17/94   4/10  Irritation Site of Applic

249         249  246 01/20/94   246 01/20/94   1/18  Irritation Site of Applic

250         250  189 11/24/93   553 11/23/94   3/22  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 100MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

251         251  106 09/02/93   722 05/11/95  23/26  Irritation Site of Applic

252         252  106 09/02/93   582 12/22/94  18/21  Irritation Site of Applic

253         253  134 09/30/93   330 04/14/94   7/12  Irritation Site of Applic

254         254  106 09/02/93   442 08/04/94  13/16  Irritation Site of Applic

255         255  106 09/02/93   526 10/27/94  16/19  Irritation Site of Applic

256         256  106 09/02/93   666 03/16/95  19/24  Irritation Site of Applic

257         257  106 09/02/93   553 11/23/94  17/20  Irritation Site of Applic

258         258  134 09/30/93   694 04/13/95  21/25  Irritation Site of Applic

259         259   78 08/05/93   498 09/29/94  16/18  Irritation Site of Applic

260         260  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

261         261  134 09/30/93   274 02/17/94   6/10  Irritation Site of Applic

262         262  106 09/02/93   722 05/11/95  23/26  Irritation Site of Applic

263         263  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

264         264  134 09/30/93   553 11/23/94  16/20  Irritation Site of Applic

265         265  134 09/30/93   526 10/27/94  15/19  Irritation Site of Applic

266         266  134 09/30/93   330 04/14/94   8/12  Irritation Site of Applic

267         267  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

268         268  134 09/30/93   553 11/23/94  16/20  Irritation Site of Applic

269         269  106 09/02/93   722 05/11/95  23/26  Irritation Site of Applic

270         270  134 09/30/93   638 02/16/95  19/23  Irritation Site of Applic

271         271  134 09/30/93   162 10/28/93   2/6   Irritation Site of Applic

272         272  106 09/02/93   526 10/27/94  16/19  Irritation Site of Applic

273         273  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

274         274  106 09/02/93   666 03/16/95  21/24  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 100MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

275         275  134 09/30/93   330 04/14/94   8/12  Irritation Site of Applic

276         276  134 09/30/93   442 08/04/94  12/16  Irritation Site of Applic

277         277  106 09/02/93   722 05/11/95  23/26  Irritation Site of Applic

278         278   78 08/05/93   498 09/29/94  15/18  Irritation Site of Applic

279         279  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

280         280  106 09/02/93   722 05/11/95  22/26  Irritation Site of Applic

281         281  106 09/02/93   553 11/23/94  17/20  Irritation Site of Applic

282         282  106 09/02/93   666 03/16/95  21/24  Irritation Site of Applic

283         283  134 09/30/93   498 09/29/94  14/18  Irritation Site of Applic

284         284  134 09/30/93   694 04/13/95  21/25  Irritation Site of Applic

285         285  134 09/30/93   302 03/17/94   7/11  Irritation Site of Applic

286         286  106 09/02/93   610 01/19/95  19/22  Irritation Site of Applic

287         287  134 09/30/93   722 05/11/95  21/26  Irritation Site of Applic

288         288  106 09/02/93   386 06/09/94  11/14  Irritation Site of Applic

289         289  106 09/02/93   162 10/28/93   3/6   Irritation Site of Applic

290         290  106 09/02/93   722 05/11/95  23/26  Irritation Site of Applic

291         291   78 08/05/93   414 07/07/94  13/15  Irritation Site of Applic

292         292  134 09/30/93   722 05/11/95  22/26  Irritation Site of Applic

293         293  134 09/30/93   414 07/07/94  11/15  Irritation Site of Applic

294         294   78 08/05/93   302 03/17/94   8/11  Irritation Site of Applic

295         295  134 09/30/93   722 05/11/95  21/26  Irritation Site of Applic

296         296  134 09/30/93   498 09/29/94  14/18  Irritation Site of Applic

297         297  134 09/30/93   498 09/29/94  14/18  Irritation Site of Applic

298         298   78 08/05/93   722 05/11/95  23/26  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    203         FIRST DOSE: 05/20/93
            SEX: FEMALE                               TRT: 100MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

299         299  134 09/30/93   610 01/19/95  18/22  Irritation Site of Applic

300         300  106 09/02/93   553 11/23/94  17/20  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 8
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:    203         FIRST DOSE: 05/19/93
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 9
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:    203         FIRST DOSE: 05/19/93
            SEX: MALE                                 TRT: 50 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

54           54  610 01/18/95   610 01/18/95   1/22  Irritation Site of Applic

63           63  582 12/21/94   722 05/10/95   6/26  Irritation Site of Applic

65           65  386 06/08/94   386 06/08/94   1/22  Irritation Site of Applic

66           66  218 12/22/93   218 12/22/93   1/24  Irritation Site of Applic

68           68  554 11/23/94   554 11/23/94   1/20  Irritation Site of Applic

74           74  302 03/16/94   610 01/18/95   2/22  Irritation Site of Applic

75           75  302 03/16/94   302 03/16/94   1/19  Irritation Site of Applic

77           77  358 05/11/94   358 05/11/94   1/22  Irritation Site of Applic

79           79  302 03/16/94   302 03/16/94   1/26  Irritation Site of Applic

80           80  246 01/19/94   610 01/18/95   2/22  Irritation Site of Applic

82           82  274 02/16/94   274 02/16/94   1/24  Irritation Site of Applic

83           83  134 09/29/93   134 09/29/93   1/22  Irritation Site of Applic

85           85  302 03/16/94   302 03/16/94   1/23  Irritation Site of Applic

92           92  722 05/10/95   722 05/10/95   1/26  Irritation Site of Applic

94           94  134 09/29/93   274 02/16/94   4/26  Irritation Site of Applic

96           96  358 05/11/94   358 05/11/94   1/21  Irritation Site of Applic

97           97  190 11/24/93   190 11/24/93   1/25  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 10
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:    203         FIRST DOSE: 05/19/93
            SEX: MALE                                 TRT: 100MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

101         101  134 09/29/93   134 09/29/93   1/25  Irritation Site of Applic

102         102  134 09/29/93   302 03/16/94   3/23  Irritation Site of Applic

103         103  134 09/29/93   134 09/29/93   1/20  Irritation Site of Applic

106         106  722 05/10/95   722 05/10/95   1/26  Irritation Site of Applic

109         109  134 09/29/93   246 01/19/94   3/17  Irritation Site of Applic

110         110  134 09/29/93   722 05/10/95  12/26  Irritation Site of Applic

111         111  134 09/29/93   162 10/27/93   2/26  Irritation Site of Applic

113         113  274 02/16/94   666 03/15/95   4/26  Irritation Site of Applic

114         114  274 02/16/94   274 02/16/94   1/26  Irritation Site of Applic

115         115  134 09/29/93   134 09/29/93   1/19  Irritation Site of Applic

117         117  610 01/18/95   722 05/10/95   5/26  Irritation Site of Applic

118         118  582 12/21/94   582 12/21/94   1/26  Irritation Site of Applic

119         119  302 03/16/94   302 03/16/94   1/19  Irritation Site of Applic

121         121  134 09/29/93   134 09/29/93   1/25  Irritation Site of Applic

123         123  134 09/29/93   638 02/15/95   2/23  Irritation Site of Applic

124         124  190 11/24/93   610 01/18/95   2/23  Irritation Site of Applic

127         127  582 12/21/94   582 12/21/94   1/23  Irritation Site of Applic

128         128  246 01/19/94   358 05/11/94   3/19  Irritation Site of Applic

131         131  610 01/18/95   610 01/18/95   1/22  Irritation Site of Applic

132         132  302 03/16/94   442 08/03/94   2/22  Irritation Site of Applic

133         133  246 01/19/94   330 04/13/94   2/25  Irritation Site of Applic

134         134  302 03/16/94   694 04/12/95   5/25  Irritation Site of Applic

135         135  162 10/27/93   414 07/06/94   8/24  Irritation Site of Applic

136         136  582 12/21/94   582 12/21/94   1/23  Irritation Site of Applic

NTP  EXP/TEST: 91014-03                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 11
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/14/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:27:08
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:    203         FIRST DOSE: 05/19/93
            SEX: MALE                                 TRT: 100MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

137         137  302 03/16/94   302 03/16/94   1/19  Irritation Site of Applic

139         139  246 01/19/94   302 03/16/94   3/26  Irritation Site of Applic

141         141  470 08/31/94   722 05/10/95  10/26  Irritation Site of Applic

143         143  190 11/24/93   302 03/16/94   5/20  Irritation Site of Applic

144         144  246 01/19/94   246 01/19/94   1/22  Irritation Site of Applic

146         146  610 01/18/95   610 01/18/95   1/23  Irritation Site of Applic

149         149  610 01/18/95   638 02/15/95   2/24  Irritation Site of Applic

150         150  694 04/12/95   694 04/12/95   1/26  Irritation Site of Applic



                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
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