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Statistical Analysis Of Non-Neoplastic Lesions

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                            OLEIC ACID DIETHANOLAMINE CONDENSATE                         DATE: 08/13/97

EXPERIMENT: 91014 TEST: 03                                                                                     TIME: 12:31:54
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: C91014
PATHOLOGIST: YARRINGTON, J.                                                                                    CAS: 93-83-4
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                            OLEIC ACID DIETHANOLAMINE CONDENSATE                         DATE: 08/13/97     
EXPERIMENT: 91014 TEST: 03                                                                                     TIME: 12:31:54     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: C91014     
PATHOLOGIST: YARRINGTON, J.                                                                                    CAS: 93-83-4       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF  OLEIC ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Vacuolization Cytoplasmic
Blood Vessel                           Mineralization
Kidney                                 Cyst
Lung                                   Inflammation Chronic
Parathyroid Gland                      Hyperplasia
Preputial Gland                        Cyst
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Hyperplasia
                                       Inflammation Chronic
                                       Parakeratosis
                                       Ulcer
Stomach, Forestomach                   Hyperkeratosis
                                       Inflammation Chronic
Stomach, Forestomach: Epithelium       Hyperplasia
Stomach, Glandular                     Mineralization
Testes                                 Degeneration
Testes: Interstitial Cell              Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Bone                                   Osteosclerosis
Kidney                                 Pigmentation Hemosiderin
Liver                                  Basophilic Focus
Pituitary Gland: Pars Distalis         Angiectasis
                                       Hyperplasia
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Hyperplasia
                                       Inflammation Chronic
                                       Parakeratosis
                                       Ulcer
Spleen                                 Fibrosis
===============================================================
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             3.0%             0.0%          |  0.0%             0.0%             6.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              707              ---           |  ---              ---              302             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.644N         P=0.536          (e)           |  P=0.078          (e)              P=0.198         |
|POLY 3             |        P=0.711N         P=0.502          (e)           |  P=0.093          (e)              P=0.206         |
|POLY 1.5           |        P=0.719N         P=0.501          (e)           |  P=0.093          (e)              P=0.214         |
|POLY 6             |        P=0.697N         P=0.505          (e)           |  P=0.094          (e)              P=0.205         |
|LOGISTIC REGRESSION|        P=0.680N         P=0.513          (e)           |  P=0.154          (e)              P=0.374         |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.095          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)     |  25/50 (50%)      19/50 (38%)      26/50 (52%)     |
|POLY-3 ADJUSTED (b)|        3.0%             6.0%             5.4%          |  65.6%            52.8%            70.1%           |
|TERMINAL (d)       |        0/8 (0%)         2/10 (20%)       2/14 (14%)    |  13/15 (87%)      13/18 (72%)      10/14 (71%)     |
|FIRST INCIDENCE    |        678              728 (T)          728 (T)       |  529              541              356             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.578          P=0.545          P=0.659       |  P=0.234          P=0.056N         P=0.238         |
|POLY 3             |        P=0.438          P=0.501          P=0.537       |  P=0.385          P=0.166N         P=0.424         |
|POLY 1.5           |        P=0.418          P=0.500          P=0.521       |  P=0.369          P=0.172N         P=0.397         |
|POLY 6             |        P=0.471          P=0.501          P=0.561       |  P=0.478          P=0.156N         P=0.544         |
|LOGISTIC REGRESSION|        P=0.564          P=0.528          P=0.636       |  P=0.141          P=0.106N         P=0.164         |
|COCH-ARM / FISHERS |        P=0.390          P=0.500          P=0.500       |  P=0.460          P=0.157N         P=0.500         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.7%          |  2.9%             2.9%             6.9%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              676           |  635              728 (T)          644             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.337          (e)              P=0.581       |  P=0.329          P=0.748N         P=0.436         |
|POLY 3             |        P=0.290          (e)              P=0.523       |  P=0.344          P=0.757          P=0.436         |
|POLY 1.5           |        P=0.281          (e)              P=0.513       |  P=0.352          P=0.755          P=0.454         |
|POLY 6             |        P=0.306          (e)              P=0.540       |  P=0.341          P=0.762N         P=0.428         |
|LOGISTIC REGRESSION|        P=0.293          (e)              P=0.532       |  P=0.318          P=0.763N         P=0.440         |
|COCH-ARM / FISHERS |        P=0.269          (e)              P=0.500       |  P=0.378          P=0.753N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        11.5%            0.0%             2.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        440              ---              703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.053N         P=0.073N         P=0.110N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.073N         P=0.062N         P=0.154N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.076N         P=0.062N         P=0.165N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.068N         P=0.064N         P=0.140N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.081N         P=0.063N         P=0.183N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.082N         P=0.059N         P=0.181N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      23/50 (46%)      13/50 (26%)   |  7/50 (14%)       7/50 (14%)       4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        29.7%            55.2%            32.6%         |  19.5%            19.5%            13.7%           |
|TERMINAL (d)       |        1/8 (13%)        3/10 (30%)       5/14 (36%)    |  2/15 (13%)       2/18 (11%)       3/14 (21%)      |
|FIRST INCIDENCE    |        440              224              497           |  579              547              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.387N         P=0.028 *        P=0.457N      |  P=0.323N         P=0.558N         P=0.369N        |
|POLY 3             |        P=0.489          P=0.014 *        P=0.487       |  P=0.356N         P=0.617          P=0.389N        |
|POLY 1.5           |        P=0.440          P=0.011 *        P=0.454       |  P=0.313N         P=0.603          P=0.346N        |
|POLY 6             |        P=0.549N         P=0.026 *        P=0.537       |  P=0.387N         P=0.594N         P=0.424N        |
|LOGISTIC REGRESSION|        P=0.363          P=0.010 *        P=0.438       |  P=0.324N         P=0.606          P=0.386N        |
|COCH-ARM / FISHERS |        P=0.373          P=0.010 *        P=0.408       |  P=0.221N         P=0.613N         P=0.262N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        5/49 (10%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.0%             8.7%             13.2%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/10 (10%)       1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        674              567              580           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.317          P=0.530          P=0.409       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.199          P=0.512          P=0.265       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.177          P=0.505          P=0.239       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.240          P=0.523          P=0.310       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.205          P=0.506          P=0.285       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.151          P=0.500          P=0.210       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        12/50 (24%)      5/50 (10%)       7/50 (14%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        33.1%            14.6%            18.3%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        473              630              576           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.030N*        P=0.062N         P=0.038N*     |  (e)              (e)              (e)             |
|POLY 3             |        P=0.078N         P=0.054N         P=0.109N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.090N         P=0.054N         P=0.126N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.063N         P=0.059N         P=0.090N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.060N         P=0.049N*        P=0.094N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.110N         P=0.054N         P=0.154N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       11/49 (22%)      6/50 (12%)    |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        25.7%            30.1%            15.9%         |  0.0%             0.0%             3.5%            |
|TERMINAL (d)       |        2/8 (25%)        0/10 (0%)        2/14 (14%)    |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        549              580              676           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.090N         P=0.445          P=0.081N      |  P=0.253          (e)              P=0.486         |
|POLY 3             |        P=0.183N         P=0.439          P=0.225N      |  P=0.282          (e)              P=0.463         |
|POLY 1.5           |        P=0.211N         P=0.408          P=0.250N      |  P=0.277          (e)              P=0.474         |
|POLY 6             |        P=0.148N         P=0.493          P=0.192N      |  P=0.287          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.168N         P=0.397          P=0.155N      |  (e)              (e)              P=0.486         |
|COCH-ARM / FISHERS |        P=0.255N         P=0.382          P=0.288N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosclerosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        0/50 (0%)     |  5/50 (10%)       0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  14.1%            0.0%             3.4%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  3/15 (20%)       0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  529              ---              563             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.048N*        P=0.025N*        P=0.147N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.043N*        P=0.032N*        P=0.148N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.041N*        P=0.032N*        P=0.133N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.042N*        P=0.029N*        P=0.154N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.048N*        P=0.032N*        P=0.141N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.037N*        P=0.028N*        P=0.102N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/49 (0%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.9%             0.0%             0.0%          |  0.0%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        618              ---              ---           |  ---              623              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.089N         P=0.261N         P=0.210N      |  P=0.691          P=0.500          (e)             |
|POLY 3             |        P=0.092N         P=0.240N         P=0.216N      |  P=0.698          P=0.500          (e)             |
|POLY 1.5           |        P=0.094N         P=0.241N         P=0.225N      |  P=0.707          P=0.497          (e)             |
|POLY 6             |        P=0.090N         P=0.241N         P=0.204N      |  P=0.694          P=0.508          (e)             |
|LOGISTIC REGRESSION|        P=0.094N         P=0.241N         P=0.235N      |  P=0.725          P=0.500          (e)             |
|COCH-ARM / FISHERS |        P=0.096N         P=0.253N         P=0.247N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/49 (4%)        2/47 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                                                        |  5.8%             6.1%             3.5%            |
|TERMINAL (d)       |                                                        |  0/15 (0%)        0/17 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |                                                        |  610              541              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.459N         P=0.671N         P=0.563N        |
|POLY 3             |                                                        |  P=0.475N         P=0.676          P=0.563N        |
|POLY 1.5           |                                                        |  P=0.447N         P=0.671          P=0.541N        |
|POLY 6             |                                                        |  P=0.494N         P=0.690          P=0.579N        |
|LOGISTIC REGRESSION|                                                        |  P=0.432N         P=0.676          P=0.561N        |
|COCH-ARM / FISHERS |                                                        |  P=0.384N         P=0.676          P=0.492N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  46/49 (94%)      44/47 (94%)      43/50 (86%)     |
|POLY-3 ADJUSTED (b)|                                                        |  97.8%            97.4%            94.5%           |
|TERMINAL (d)       |                                                        |  15/15 (100%)     17/17 (100%)     14/14 (100%)    |
|FIRST INCIDENCE    |                                                        |  429              244              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.325          P=0.348N         P=0.335         |
|POLY 3             |                                                        |  P=0.240N         P=0.735N         P=0.353N        |
|POLY 1.5           |                                                        |  P=0.163N         P=0.726N         P=0.248N        |
|POLY 6             |                                                        |  P=0.392N         P=0.712N         P=0.556N        |
|LOGISTIC REGRESSION|                                                        |  P=0.306N         P=0.519          P=0.411N        |
|COCH-ARM / FISHERS |                                                        |  P=0.114N         P=0.641N         P=0.167N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/2 (50%)        0/0 (0%)         1/1 (100%)    |  0/3 (0%)         1/3 (33%)        3/6 (50%)       |
|POLY-3 ADJUSTED (b)|        58.0%            0.0%             100.0%        |  0.0%             46.0%            64.0%           |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         1/1 (100%)    |  0/1 (0%)         1/1 (100%)       3/4 (75%)       |
|FIRST INCIDENCE    |        440              ---              728 (T)       |  ---              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.254N         P=0.529N         P=0.467N      |  P=0.302          P=0.500          P=0.419         |
|POLY 3             |        P=1.000          P=1.000          P=0.694       |  P=0.092          P=0.464          P=0.155         |
|POLY 1.5           |        P=1.000          P=1.000          P=0.651       |  P=0.109          P=0.479          P=0.177         |
|POLY 6             |        P=1.000          P=1.000          P=0.789       |  P=0.085          P=0.451          P=0.153         |
|LOGISTIC REGRESSION|        P=0.221          (e)              P=0.547       |  (e)              P=0.500          P=0.419         |
|COCH-ARM / FISHERS |        P=0.414          P=1.000          P=0.667       |  P=0.134          P=0.500          P=0.238         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/2 (0%)         0/0 (0%)         1/1 (100%)    |  2/3 (67%)        3/3 (100%)       4/6 (67%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             100.0%        |  74.6%            100.0%           85.3%           |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         1/1 (100%)    |  1/1 (100%)       1/1 (100%)       4/4 (100%)      |
|FIRST INCIDENCE    |        ---              ---              728 (T)       |  698              508              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=1.000N         (e)              P=1.000N      |  P=0.410N         P=0.527          P=0.527N        |
|POLY 3             |        P=1.000N         (e)              P=0.535       |  P=0.627          P=0.651          P=0.763         |
|POLY 1.5           |        P=1.000N         (e)              P=0.238       |  P=0.658          P=0.570          P=0.744         |
|POLY 6             |        P=1.000N         (e)              P=0.742       |  P=0.648          P=0.829          P=0.864         |
|LOGISTIC REGRESSION|        (e)              (e)              P=1.000N      |  P=0.597          P=0.448          P=0.527N        |
|COCH-ARM / FISHERS |        P=0.140          (e)              P=0.333       |  P=0.580N         P=0.500          P=0.762         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        34/50 (68%)      38/49 (78%)      33/50 (66%)   |  18/50 (36%)      20/50 (40%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        77.5%            85.4%            75.0%         |  45.9%            54.3%            44.8%           |
|TERMINAL (d)       |        8/8 (100%)       10/10 (100%)     14/14 (100%)  |  4/15 (27%)       14/18 (78%)      7/14 (50%)      |
|FIRST INCIDENCE    |        440              331              482           |  462              524              394             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.056N         P=0.424          P=0.059N      |  P=0.406N         P=0.562          P=0.454N        |
|POLY 3             |        P=0.427N         P=0.218          P=0.488N      |  P=0.544          P=0.300          P=0.561N        |
|POLY 1.5           |        P=0.424N         P=0.202          P=0.479N      |  P=0.440N         P=0.333          P=0.448N        |
|POLY 6             |        P=0.448N         P=0.247          P=0.518N      |  P=0.429          P=0.268          P=0.536         |
|LOGISTIC REGRESSION|        P=0.338N         P=0.203          P=0.370N      |  P=0.470N         P=0.391          P=0.478N        |
|COCH-ARM / FISHERS |        P=0.456N         P=0.200          P=0.500N      |  P=0.231N         P=0.418          P=0.260N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       4/49 (8%)        7/50 (14%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        19.9%            11.8%            18.3%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        571              630              576           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.323N         P=0.288N         P=0.346N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.512N         P=0.274N         P=0.553N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.532N         P=0.274N         P=0.576N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.482N         P=0.281N         P=0.521N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.466N         P=0.261N         P=0.525N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.561          P=0.274N         P=0.613N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        4/49 (8%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.0%             11.6%            2.7%          |  2.9%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        694              567              580           |  718              702              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.509N         P=0.188          P=0.714N      |  P=0.338N         P=0.711N         P=0.513N        |
|POLY 3             |        P=0.534N         P=0.184          P=0.734N      |  P=0.399N         P=0.760          P=0.537N        |
|POLY 1.5           |        P=0.563N         P=0.178          P=0.746N      |  P=0.379N         P=0.757          P=0.526N        |
|POLY 6             |        P=0.487N         P=0.196          P=0.715N      |  P=0.410N         P=0.757N         P=0.543N        |
|LOGISTIC REGRESSION|        P=0.595N         P=0.177          P=0.765N      |  P=0.366N         P=0.750N         P=0.531N        |
|COCH-ARM / FISHERS |        P=0.600          P=0.175          P=0.753N      |  P=0.331N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        3/48 (6%)        2/49 (4%)     |  0/47 (0%)        0/50 (0%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             9.2%             5.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              630              677           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.310          P=0.122          P=0.344       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.260          P=0.118          P=0.268       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.233          P=0.116          P=0.254       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.307          P=0.123          P=0.291       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.252          P=0.119          P=0.292       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.202          P=0.117          P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/49 (6%)        1/48 (2%)        2/49 (4%)     |  2/47 (4%)        3/50 (6%)        4/48 (8%)       |
|POLY-3 ADJUSTED (b)|        8.8%             3.1%             5.4%          |  5.8%             8.4%             14.0%           |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        2/14 (14%)    |  0/15 (0%)        1/18 (6%)        3/14 (21%)      |
|FIRST INCIDENCE    |        495              483              728 (T)       |  462              371              709             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.308N         P=0.305N         P=0.376N      |  P=0.222          P=0.518          P=0.298         |
|POLY 3             |        P=0.377N         P=0.316N         P=0.464N      |  P=0.200          P=0.515          P=0.251         |
|POLY 1.5           |        P=0.387N         P=0.315N         P=0.479N      |  P=0.221          P=0.514          P=0.281         |
|POLY 6             |        P=0.362N         P=0.319N         P=0.443N      |  P=0.187          P=0.525          P=0.228         |
|LOGISTIC REGRESSION|        P=0.446N         P=0.290N         P=0.530N      |  P=0.243          P=0.594          P=0.259         |
|COCH-ARM / FISHERS |        P=0.400N         P=0.316N         P=0.500N      |  P=0.270          P=0.530          P=0.349         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/48 (4%)        0/49 (0%)        2/48 (4%)     |  1/38 (3%)        1/47 (2%)        2/46 (4%)       |
|POLY-3 ADJUSTED (b)|        6.1%             0.0%             5.5%          |  3.5%             3.0%             7.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        1/14 (7%)     |  1/15 (7%)        1/18 (6%)        1/14 (7%)       |
|FIRST INCIDENCE    |        603              ---              661           |  728 (T)          728 (T)          574             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.489N         P=0.212N         P=0.545N      |  P=0.330          P=0.722N         P=0.442         |
|POLY 3             |        P=0.611N         P=0.234N         P=0.660N      |  P=0.396          P=0.732N         P=0.496         |
|POLY 1.5           |        P=0.616N         P=0.234N         P=0.674N      |  P=0.408          P=0.727N         P=0.518         |
|POLY 6             |        P=0.599N         P=0.235N         P=0.637N      |  P=0.388          P=0.734N         P=0.480         |
|LOGISTIC REGRESSION|        P=0.568N         P=0.233N         P=0.640N      |  P=0.356          P=0.722N         P=0.491         |
|COCH-ARM / FISHERS |        P=0.622          P=0.242N         P=0.692N      |  P=0.435          P=0.697N         P=0.572         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.9%             5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              653              677           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.278          P=0.248          P=0.344       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.214          P=0.240          P=0.264       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.197          P=0.238          P=0.252       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.244          P=0.243          P=0.284       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.225          P=0.241          P=0.286       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.176          P=0.247          P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              696           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.162          (e)              P=0.366       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.105          (e)              P=0.263       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.100          (e)              P=0.251       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.113          (e)              P=0.282       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.137          (e)              P=0.317       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       12/50 (24%)      4/50 (8%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        14.6%            33.9%            10.5%         |  2.8%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         3/10 (30%)       0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        638              580              638           |  447              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.202N         P=0.085          P=0.308N      |  P=0.292N         P=0.513N         P=0.533N        |
|POLY 3             |        P=0.327N         P=0.048 *        P=0.435N      |  P=0.306N         P=0.507N         P=0.541N        |
|POLY 1.5           |        P=0.375N         P=0.050          P=0.462N      |  P=0.295N         P=0.507N         P=0.529N        |
|POLY 6             |        P=0.258N         P=0.046 *        P=0.394N      |  P=0.313N         P=0.502N         P=0.549N        |
|LOGISTIC REGRESSION|        P=0.308N         P=0.050          P=0.422N      |  P=0.175N         P=0.411N         P=0.371N        |
|COCH-ARM / FISHERS |        P=0.443N         P=0.054          P=0.500N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      5/50 (10%)       7/50 (14%)    |  35/50 (70%)      37/50 (74%)      37/50 (74%)     |
|POLY-3 ADJUSTED (b)|        27.7%            14.1%            18.3%         |  79.6%            77.9%            79.8%           |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        1/14 (7%)     |  11/15 (73%)      11/18 (61%)      9/14 (64%)      |
|FIRST INCIDENCE    |        473              440              576           |  423              270              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.098N         P=0.150N         P=0.103N      |  P=0.162          P=0.552N         P=0.173         |
|POLY 3             |        P=0.197N         P=0.125N         P=0.241N      |  P=0.543          P=0.524N         P=0.601         |
|POLY 1.5           |        P=0.214N         P=0.128N         P=0.263N      |  P=0.459          P=0.570          P=0.510         |
|POLY 6             |        P=0.174N         P=0.125N         P=0.213N      |  P=0.487N         P=0.408N         P=0.535N        |
|LOGISTIC REGRESSION|        P=0.200N         P=0.131N         P=0.225N      |  P=0.422          P=0.409          P=0.426         |
|COCH-ARM / FISHERS |        P=0.240N         P=0.131N         P=0.298N      |  P=0.368          P=0.412          P=0.412         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        40/50 (80%)      42/50 (84%)      40/50 (80%)   |  9/50 (18%)       8/50 (16%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        89.0%            93.1%            87.5%         |  24.8%            23.3%            17.3%           |
|TERMINAL (d)       |        8/8 (100%)       10/10 (100%)     13/14 (93%)   |  6/15 (40%)       7/18 (39%)       4/14 (29%)      |
|FIRST INCIDENCE    |        440              483              497           |  462              722              695             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.055N         P=0.544          P=0.059N      |  P=0.187N         P=0.361N         P=0.256N        |
|POLY 3             |        P=0.464N         P=0.348          P=0.549N      |  P=0.299N         P=0.553N         P=0.332N        |
|POLY 1.5           |        P=0.491N         P=0.344          P=0.558N      |  P=0.251N         P=0.542N         P=0.283N        |
|POLY 6             |        P=0.424N         P=0.418          P=0.546N      |  P=0.333N         P=0.552N         P=0.369N        |
|LOGISTIC REGRESSION|        P=0.291N         P=0.405          P=0.362N      |  P=0.265N         P=0.475N         P=0.321N        |
|COCH-ARM / FISHERS |        P=0.551          P=0.398          P=0.598N      |  P=0.161N         P=0.500N         P=0.194N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       5/50 (10%)       8/50 (16%)    |  4/50 (8%)        3/50 (6%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        14.2%            14.1%            20.7%         |  11.2%            8.6%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/10 (10%)       1/14 (7%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        440              483              580           |  579              623              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.419          P=0.608N         P=0.495       |  P=0.074N         P=0.467N         P=0.100N        |
|POLY 3             |        P=0.268          P=0.630N         P=0.334       |  P=0.083N         P=0.514N         P=0.091N        |
|POLY 1.5           |        P=0.247          P=0.631N         P=0.308       |  P=0.070N         P=0.516N         P=0.080N        |
|POLY 6             |        P=0.308          P=0.630N         P=0.381       |  P=0.093N         P=0.503N         P=0.100N        |
|LOGISTIC REGRESSION|        P=0.226          P=0.630N         P=0.300       |  P=0.065N         P=0.506N         P=0.082N        |
|COCH-ARM / FISHERS |        P=0.221          P=0.630N         P=0.277       |  P=0.049N*        P=0.500N         P=0.059N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.9%             2.9%             0.0%          |  0.0%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        603              603              ---           |  ---              685              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.133N         P=0.511N         P=0.220N      |  P=0.711          P=0.517          (e)             |
|POLY 3             |        P=0.130N         P=0.501N         P=0.217N      |  P=0.698          P=0.499          (e)             |
|POLY 1.5           |        P=0.135N         P=0.501N         P=0.225N      |  P=0.707          P=0.496          (e)             |
|POLY 6             |        P=0.122N         P=0.502N         P=0.205N      |  P=0.694          P=0.506          (e)             |
|LOGISTIC REGRESSION|        P=0.148N         P=0.500N         P=0.249N      |  P=0.709          P=0.502          (e)             |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.247N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  1/50 (2%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             3.0%             2.7%          |  2.9%             5.8%             6.9%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        2/18 (11%)       1/14 (7%)       |
|FIRST INCIDENCE    |        ---              637              631           |  679              728 (T)          692             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.370          P=0.469          P=0.532       |  P=0.346          P=0.547          P=0.447         |
|POLY 3             |        P=0.374          P=0.504          P=0.524       |  P=0.332          P=0.494          P=0.435         |
|POLY 1.5           |        P=0.356          P=0.501          P=0.514       |  P=0.348          P=0.491          P=0.454         |
|POLY 6             |        P=0.405          P=0.508          P=0.541       |  P=0.325          P=0.503          P=0.425         |
|LOGISTIC REGRESSION|        P=0.332          P=0.500          P=0.496       |  P=0.320          P=0.525          P=0.428         |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.390          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.0%             6.0%             2.7%          |  0.0%             2.9%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        2/10 (20%)       1/14 (7%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        659              728 (T)          728 (T)       |  ---              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.215N         P=0.637N         P=0.330N      |  P=0.729          P=0.536          (e)             |
|POLY 3             |        P=0.354N         P=0.696N         P=0.464N      |  P=0.698          P=0.498          (e)             |
|POLY 1.5           |        P=0.370N         P=0.695          P=0.479N      |  P=0.707          P=0.496          (e)             |
|POLY 6             |        P=0.329N         P=0.699          P=0.440N      |  P=0.694          P=0.504          (e)             |
|LOGISTIC REGRESSION|        P=0.245N         P=0.675N         P=0.385N      |  (e)              P=0.536          (e)             |
|COCH-ARM / FISHERS |        P=0.390N         P=0.691N         P=0.500N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       11/50 (22%)      7/50 (14%)    |  18/50 (36%)      15/50 (30%)      11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        20.7%            31.4%            18.7%         |  51.0%            43.0%            35.9%           |
|TERMINAL (d)       |        5/8 (63%)        6/10 (60%)       5/14 (36%)    |  15/15 (100%)     14/18 (78%)      7/14 (50%)      |
|FIRST INCIDENCE    |        654              580              676           |  635              541              560             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.162N         P=0.289          P=0.212N      |  P=0.059N         P=0.042N*        P=0.112N        |
|POLY 3             |        P=0.443N         P=0.226          P=0.531N      |  P=0.123N         P=0.324N         P=0.147N        |
|POLY 1.5           |        P=0.491N         P=0.219          P=0.567N      |  P=0.119N         P=0.349N         P=0.140N        |
|POLY 6             |        P=0.363N         P=0.238          P=0.472N      |  P=0.093N         P=0.262N         P=0.115N        |
|LOGISTIC REGRESSION|        P=0.284N         P=0.206          P=0.312N      |  P=0.177N         P=0.167N         P=0.233N        |
|COCH-ARM / FISHERS |        P=0.553          P=0.218          P=0.613N      |  P=0.077N         P=0.335N         P=0.093N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.9%             2.7%          |  0.0%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       0/14 (0%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              549              713           |  ---              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.489          P=0.275          P=0.650       |  P=0.729          P=0.536          (e)             |
|POLY 3             |        P=0.414          P=0.241          P=0.522       |  P=0.698          P=0.498          (e)             |
|POLY 1.5           |        P=0.391          P=0.239          P=0.513       |  P=0.707          P=0.496          (e)             |
|POLY 6             |        P=0.452          P=0.245          P=0.538       |  P=0.694          P=0.504          (e)             |
|LOGISTIC REGRESSION|        P=0.392          P=0.238          P=0.581       |  (e)              P=0.536          (e)             |
|COCH-ARM / FISHERS |        P=0.360          P=0.247          P=0.500       |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.8%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        440              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.093N         P=0.252N         P=0.224N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.092N         P=0.241N         P=0.219N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.093N         P=0.240N         P=0.226N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.089N         P=0.243N         P=0.207N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.110N         P=0.226N         P=0.322N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        3/50 (6%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             3.0%             0.0%          |  0.0%             8.7%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       0/14 (0%)     |  0/15 (0%)        2/18 (11%)       0/14 (0%)       |
|FIRST INCIDENCE    |        ---              728 (T)          ---           |  ---              722              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.651N         P=0.545          (e)           |  P=0.633          P=0.159          (e)             |
|POLY 3             |        P=0.711N         P=0.502          (e)           |  P=0.549          P=0.115          (e)             |
|POLY 1.5           |        P=0.719N         P=0.500          (e)           |  P=0.577          P=0.114          (e)             |
|POLY 6             |        P=0.697N         P=0.503          (e)           |  P=0.534          P=0.119          (e)             |
|LOGISTIC REGRESSION|        (e)              P=0.545          (e)           |  P=0.629          P=0.147          (e)             |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.640          P=0.121          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        7/50 (14%)       5/50 (10%)    |  7/50 (14%)       14/50 (28%)      11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        11.4%            19.3%            13.1%         |  18.8%            37.2%            32.9%           |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       2/14 (14%)    |  1/15 (7%)        6/18 (33%)       3/14 (21%)      |
|FIRST INCIDENCE    |        506              331              580           |  524              270              331             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.524N         P=0.290          P=0.619N      |  P=0.122          P=0.128          P=0.134         |
|POLY 3             |        P=0.502          P=0.272          P=0.551       |  P=0.103          P=0.059          P=0.134         |
|POLY 1.5           |        P=0.475          P=0.267          P=0.530       |  P=0.123          P=0.060          P=0.153         |
|POLY 6             |        P=0.545          P=0.277          P=0.583       |  P=0.100          P=0.062          P=0.130         |
|LOGISTIC REGRESSION|        P=0.402          P=0.263          P=0.495       |  P=0.178          P=0.068          P=0.223         |
|COCH-ARM / FISHERS |        P=0.436          P=0.262          P=0.500       |  P=0.196          P=0.070          P=0.218         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        2/50 (4%)     |  13/50 (26%)      7/50 (14%)       9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        5.9%             11.1%            5.4%          |  34.7%            19.2%            26.5%           |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        2/14 (14%)    |  6/15 (40%)       2/18 (11%)       1/14 (7%)       |
|FIRST INCIDENCE    |        638              224              728 (T)       |  462              371              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.490N         P=0.330          P=0.564N      |  P=0.313N         P=0.085N         P=0.384N        |
|POLY 3             |        P=0.539N         P=0.366          P=0.662N      |  P=0.233N         P=0.102N         P=0.306N        |
|POLY 1.5           |        P=0.559N         P=0.354          P=0.675N      |  P=0.226N         P=0.109N         P=0.293N        |
|POLY 6             |        P=0.510N         P=0.380          P=0.643N      |  P=0.219N         P=0.087N         P=0.290N        |
|LOGISTIC REGRESSION|        P=0.507          P=0.353          P=0.624N      |  P=0.186N         P=0.111N         P=0.233N        |
|COCH-ARM / FISHERS |        P=0.588          P=0.339          P=0.691N      |  P=0.188N         P=0.105N         P=0.235N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        5/50 (10%)    |  1/50 (2%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        8.9%             8.8%             13.5%         |  2.9%             5.8%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/10 (10%)       5/14 (36%)    |  1/15 (7%)        2/18 (11%)       0/14 (0%)       |
|FIRST INCIDENCE    |        638              621              728 (T)       |  728 (T)          728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.552          P=0.617N         P=0.656N      |  P=0.371N         P=0.565          P=0.514N        |
|POLY 3             |        P=0.328          P=0.661N         P=0.410       |  P=0.452N         P=0.496          P=0.537N        |
|POLY 1.5           |        P=0.309          P=0.662N         P=0.388       |  P=0.425N         P=0.492          P=0.526N        |
|POLY 6             |        P=0.359          P=0.660N         P=0.444       |  P=0.466N         P=0.508          P=0.543N        |
|LOGISTIC REGRESSION|        P=0.465          P=0.655N         P=0.596       |  P=0.371N         P=0.565          (e)             |
|COCH-ARM / FISHERS |        P=0.283          P=0.661N         P=0.357       |  P=0.360N         P=0.500          P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.9%             0.0%             5.3%          |  2.9%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        618              ---              628           |  635              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.538N         P=0.232N         P=0.602N      |  P=0.312N         P=0.513N         P=0.568N        |
|POLY 3             |        P=0.607N         P=0.237N         P=0.653N      |  P=0.304N         P=0.504N         P=0.539N        |
|POLY 1.5           |        P=0.614N         P=0.237N         P=0.671N      |  P=0.294N         P=0.505N         P=0.527N        |
|POLY 6             |        P=0.593N         P=0.237N         P=0.624N      |  P=0.310N         P=0.500N         P=0.546N        |
|LOGISTIC REGRESSION|        P=0.607N         P=0.235N         P=0.684N      |  P=0.279N         P=0.502N         P=0.522N        |
|COCH-ARM / FISHERS |        P=0.622          P=0.247N         P=0.691N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      12/50 (24%)      15/50 (30%)   |  3/50 (6%)        3/50 (6%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        28.3%            31.9%            36.8%         |  8.4%             8.7%             6.8%            |
|TERMINAL (d)       |        2/8 (25%)        1/10 (10%)       4/14 (29%)    |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        542              549              497           |  462              623              560             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.433          P=0.420          P=0.513       |  P=0.497N         P=0.624N         P=0.597N        |
|POLY 3             |        P=0.247          P=0.468          P=0.289       |  P=0.516N         P=0.649          P=0.590N        |
|POLY 1.5           |        P=0.200          P=0.433          P=0.236       |  P=0.486N         P=0.647          P=0.563N        |
|POLY 6             |        P=0.330          P=0.529          P=0.380       |  P=0.531N         P=0.659          P=0.604N        |
|LOGISTIC REGRESSION|        P=0.195          P=0.409          P=0.252       |  P=0.460N         P=0.658          P=0.517N        |
|COCH-ARM / FISHERS |        P=0.148          P=0.405          P=0.178       |  P=0.412N         P=0.661N         P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        8.7%             11.8%            5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         2/10 (20%)       0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        580              621              580           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.286N         P=0.537          P=0.436N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.365N         P=0.491          P=0.458N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.387N         P=0.495          P=0.475N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.332N         P=0.483          P=0.432N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.384N         P=0.505          P=0.541N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.417N         P=0.500          P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             5.6%             6.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              244              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.143          P=0.236          P=0.207         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.147          P=0.242          P=0.207         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.154          P=0.237          P=0.215         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.146          P=0.252          P=0.205         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.383          P=0.330          P=0.479         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.176          P=0.247          P=0.247         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              647           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.138          (e)              P=0.315       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.105          (e)              P=0.264       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.100          (e)              P=0.252       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.114          (e)              P=0.284       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.120          (e)              P=0.283       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       0/50 (0%)        4/50 (8%)     |  5/50 (10%)       3/50 (6%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        14.4%            0.0%             10.6%         |  14.2%            8.6%             13.8%           |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        2/14 (14%)    |  2/15 (13%)       2/18 (11%)       3/14 (21%)      |
|FIRST INCIDENCE    |        469              ---              611           |  653              567              695             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.267N         P=0.037N*        P=0.306N      |  P=0.496N         P=0.294N         P=0.571N        |
|POLY 3             |        P=0.393N         P=0.031N*        P=0.448N      |  P=0.527N         P=0.359N         P=0.624N        |
|POLY 1.5           |        P=0.404N         P=0.031N*        P=0.470N      |  P=0.499N         P=0.366N         P=0.586N        |
|POLY 6             |        P=0.373N         P=0.032N*        P=0.416N      |  P=0.542N         P=0.342N         P=0.636         |
|LOGISTIC REGRESSION|        P=0.377N         P=0.033N*        P=0.457N      |  P=0.545N         P=0.345N         P=0.627N        |
|COCH-ARM / FISHERS |        P=0.417N         P=0.028N*        P=0.500N      |  P=0.427N         P=0.357N         P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       3/50 (6%)        3/50 (6%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        14.6%            8.8%             7.9%          |  0.0%             0.0%             3.5%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        608              630              535           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.160N         P=0.353N         P=0.204N      |  P=0.253          (e)              P=0.486         |
|POLY 3             |        P=0.236N         P=0.355N         P=0.297N      |  P=0.282          (e)              P=0.463         |
|POLY 1.5           |        P=0.256N         P=0.356N         P=0.322N      |  P=0.277          (e)              P=0.474         |
|POLY 6             |        P=0.207N         P=0.355N         P=0.263N      |  P=0.287          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.233N         P=0.347N         P=0.309N      |  (e)              (e)              P=0.486         |
|COCH-ARM / FISHERS |        P=0.283N         P=0.357N         P=0.357N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        5/48 (10%)       5/50 (10%)    |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.1%             15.1%            13.1%         |  2.9%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       2/14 (14%)    |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        647              623              580           |  694              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.340          P=0.208          P=0.363       |  P=0.357N         P=0.740N         P=0.542N        |
|POLY 3             |        P=0.250          P=0.213          P=0.276       |  P=0.400N         P=0.758          P=0.538N        |
|POLY 1.5           |        P=0.222          P=0.209          P=0.254       |  P=0.379N         P=0.756          P=0.527N        |
|POLY 6             |        P=0.298          P=0.222          P=0.314       |  P=0.412N         P=0.760N         P=0.544N        |
|LOGISTIC REGRESSION|        P=0.241          P=0.212          P=0.271       |  P=0.365N         P=0.749N         P=0.541N        |
|COCH-ARM / FISHERS |        P=0.187          P=0.209          P=0.226       |  P=0.331N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/49 (18%)       16/49 (33%)      12/49 (24%)   |  9/49 (18%)       11/49 (22%)      7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        26.3%            43.0%            30.7%         |  25.4%            31.9%            22.5%           |
|TERMINAL (d)       |        2/8 (25%)        4/10 (40%)       3/14 (21%)    |  3/14 (21%)       5/18 (28%)       0/14 (0%)       |
|FIRST INCIDENCE    |        608              549              554           |  529              635              463             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.450N         P=0.131          P=0.520N      |  P=0.473N         P=0.534          P=0.541N        |
|POLY 3             |        P=0.440          P=0.099          P=0.437       |  P=0.483N         P=0.364          P=0.505N        |
|POLY 1.5           |        P=0.367          P=0.088          P=0.381       |  P=0.445N         P=0.365          P=0.472N        |
|POLY 6             |        P=0.555          P=0.123          P=0.525       |  P=0.485N         P=0.385          P=0.509N        |
|LOGISTIC REGRESSION|        P=0.393          P=0.080          P=0.454       |  P=0.484N         P=0.418          P=0.496N        |
|COCH-ARM / FISHERS |        P=0.280          P=0.082          P=0.312       |  P=0.331N         P=0.401          P=0.376N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/49 (12%)       8/49 (16%)       10/49 (20%)   |  1/49 (2%)        2/49 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        17.2%            22.5%            25.9%         |  2.9%             5.9%             3.5%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       4/14 (29%)    |  0/14 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        530              549              549           |  462              667              726             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.364          P=0.398          P=0.435       |  P=0.593          P=0.532          P=0.742         |
|POLY 3             |        P=0.224          P=0.396          P=0.266       |  P=0.563          P=0.493          P=0.720         |
|POLY 1.5           |        P=0.200          P=0.389          P=0.240       |  P=0.581          P=0.490          P=0.734         |
|POLY 6             |        P=0.267          P=0.412          P=0.310       |  P=0.555          P=0.507          P=0.713         |
|LOGISTIC REGRESSION|        P=0.183          P=0.387          P=0.230       |  P=0.594          P=0.501          P=0.762N        |
|COCH-ARM / FISHERS |        P=0.169          P=0.387          P=0.207       |  P=0.615N         P=0.500          P=0.747N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        0/49 (0%)        0/49 (0%)     |  0/49 (0%)        0/49 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.2%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  0/14 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        700              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.056N         P=0.215N         P=0.139N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.091N         P=0.235N         P=0.210N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.093N         P=0.236N         P=0.221N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.088N         P=0.233N         P=0.193N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.058N         P=0.215N         P=0.144N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/5 (80%)        5/7 (71%)        2/3 (67%)     |  3/3 (100%)       3/3 (100%)       0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        80.0%            81.3%            75.7%         |  100.0%           100.0%           0.0%            |
|TERMINAL (d)       |        0/1 (0%)         1/1 (100%)       0/0 (0%)      |  1/1 (100%)       1/1 (100%)       0/0 (0%)        |
|FIRST INCIDENCE    |        440              653              631           |  560              528              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.187N         P=0.558          P=0.209N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.649N         P=0.764          P=0.761N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.567N         P=0.716N         P=0.708N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.647          P=0.690          P=0.792       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.456N         P=0.613N         P=0.676N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.489N         P=0.636N         P=0.643N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/5 (0%)         2/7 (29%)        0/3 (0%)      |  0/3 (0%)         0/3 (0%)         0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             34.1%            0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/1 (0%)         0/1 (0%)         0/0 (0%)      |  0/1 (0%)         0/1 (0%)         0/0 (0%)        |
|FIRST INCIDENCE    |        ---              668              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.545N         P=0.293          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.621          P=0.336          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.620          P=0.324          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.603          P=0.347          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.605          P=0.319          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.597          P=0.318          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        3/50 (6%)     |  2/49 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        11.6%            0.0%             7.9%          |  5.9%             5.7%             3.4%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  1/15 (7%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        517              ---              636           |  635              567              644             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.342N         P=0.075N         P=0.415N      |  P=0.462N         P=0.674N         P=0.572N        |
|POLY 3             |        P=0.384N         P=0.062N         P=0.447N      |  P=0.462N         P=0.689N         P=0.556N        |
|POLY 1.5           |        P=0.394N         P=0.061N         P=0.470N      |  P=0.440N         P=0.693N         P=0.538N        |
|POLY 6             |        P=0.363N         P=0.064N         P=0.413N      |  P=0.472N         P=0.677N         P=0.565N        |
|LOGISTIC REGRESSION|        P=0.407N         P=0.063N         P=0.512N      |  P=0.435N         P=0.691N         P=0.555N        |
|COCH-ARM / FISHERS |        P=0.406N         P=0.059N         P=0.500N      |  P=0.383N         P=0.684N         P=0.492N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)     |  0/49 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             3.0%             5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              653              580           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.183          P=0.482          P=0.293       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.169          P=0.503          P=0.266       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.157          P=0.501          P=0.253       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.191          P=0.507          P=0.287       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.147          P=0.501          P=0.236       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.142          P=0.500          P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/50 (0%)        3/50 (6%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             8.4%             0.0%            |
|TERMINAL (d)       |                                                        |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              270              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.602          P=0.134          (e)             |
|POLY 3             |                                                        |  P=0.548          P=0.121          (e)             |
|POLY 1.5           |                                                        |  P=0.576          P=0.118          (e)             |
|POLY 6             |                                                        |  P=0.534          P=0.130          (e)             |
|LOGISTIC REGRESSION|                                                        |  P=0.583N         P=0.139          (e)             |
|COCH-ARM / FISHERS |                                                        |  P=0.640          P=0.121          (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary: Periovarian Tissue                                                                                                        |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  3/50 (6%)        8/50 (16%)       3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                                                        |  8.4%             22.3%            10.4%           |
|TERMINAL (d)       |                                                        |  1/15 (7%)        5/18 (28%)       3/14 (21%)      |
|FIRST INCIDENCE    |                                                        |  571              244              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.481          P=0.132          P=0.581         |
|POLY 3             |                                                        |  P=0.392          P=0.092          P=0.561         |
|POLY 1.5           |                                                        |  P=0.447          P=0.092          P=0.594         |
|POLY 6             |                                                        |  P=0.353          P=0.098          P=0.535         |
|LOGISTIC REGRESSION|                                                        |  P=0.470          P=0.096          P=0.571         |
|COCH-ARM / FISHERS |                                                        |  P=0.568          P=0.100          P=0.661N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        6/50 (12%)       3/50 (6%)     |  3/50 (6%)        5/50 (10%)       1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        8.8%             17.1%            7.9%          |  8.4%             14.3%            3.4%            |
|TERMINAL (d)       |        0/8 (0%)         2/10 (20%)       1/14 (7%)     |  0/15 (0%)        3/18 (17%)       0/14 (0%)       |
|FIRST INCIDENCE    |        571              528              611           |  462              579              394             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.403N         P=0.287          P=0.535N      |  P=0.329N         P=0.409          P=0.365N        |
|POLY 3             |        P=0.499N         P=0.250          P=0.614N      |  P=0.379N         P=0.342          P=0.373N        |
|POLY 1.5           |        P=0.531N         P=0.246          P=0.635N      |  P=0.343N         P=0.340          P=0.353N        |
|POLY 6             |        P=0.448N         P=0.255          P=0.581N      |  P=0.401N         P=0.357          P=0.386N        |
|LOGISTIC REGRESSION|        P=0.532N         P=0.244          P=0.633N      |  P=0.298N         P=0.349          P=0.257N        |
|COCH-ARM / FISHERS |        P=0.573          P=0.243          P=0.661N      |  P=0.264N         P=0.357          P=0.309N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        17/45 (38%)      18/47 (38%)      12/50 (24%)   |  0/42 (0%)        0/43 (0%)        1/42 (2%)       |
|POLY-3 ADJUSTED (b)|        49.9%            49.3%            31.3%         |  0.0%             0.0%             4.0%            |
|TERMINAL (d)       |        3/8 (38%)        1/9 (11%)        5/14 (36%)    |  0/11 (0%)        0/15 (0%)        1/13 (8%)       |
|FIRST INCIDENCE    |        549              497              526           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.032N*        P=0.516          P=0.025N*     |  P=0.283          (e)              P=0.533         |
|POLY 3             |        P=0.056N         P=0.580N         P=0.074N      |  P=0.279          (e)              P=0.470         |
|POLY 1.5           |        P=0.064N         P=0.589          P=0.083N      |  P=0.275          (e)              P=0.477         |
|POLY 6             |        P=0.055N         P=0.554N         P=0.072N      |  P=0.281          (e)              P=0.469         |
|LOGISTIC REGRESSION|        P=0.040N*        P=0.550          P=0.038N*     |  (e)              (e)              P=0.533         |
|COCH-ARM / FISHERS |        P=0.090N         P=0.565          P=0.109N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/49 (0%)     |  3/50 (6%)        2/50 (4%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  8.4%             5.8%             13.5%           |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  1/15 (7%)        1/18 (6%)        2/14 (14%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  579              667              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.334          P=0.478N         P=0.402         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.354          P=0.513N         P=0.399         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.370          P=0.514N         P=0.428         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.347          P=0.505N         P=0.384         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.333          P=0.504N         P=0.410         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.417          P=0.500N         P=0.500         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/49 (4%)     |  8/50 (16%)       6/50 (12%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        3.0%             5.9%             5.4%          |  21.1%            16.8%            16.8%           |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       1/14 (7%)     |  2/15 (13%)       3/18 (17%)       2/14 (14%)      |
|FIRST INCIDENCE    |        634              653              576           |  429              397              519             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.500          P=0.498          P=0.590       |  P=0.327N         P=0.360N         P=0.398N        |
|POLY 3             |        P=0.436          P=0.502          P=0.534       |  P=0.376N         P=0.432N         P=0.445N        |
|POLY 1.5           |        P=0.413          P=0.501          P=0.516       |  P=0.326N         P=0.423N         P=0.388N        |
|POLY 6             |        P=0.473          P=0.504          P=0.561       |  P=0.410N         P=0.431N         P=0.488N        |
|LOGISTIC REGRESSION|        P=0.425          P=0.505          P=0.506       |  P=0.270N         P=0.384N         P=0.320N        |
|COCH-ARM / FISHERS |        P=0.383          P=0.500          P=0.492       |  P=0.226N         P=0.387N         P=0.277N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/49 (0%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        5.9%             0.0%             0.0%          |  0.0%             2.9%             3.4%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        598              ---              ---           |  ---              524              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.077N         P=0.240N         P=0.190N      |  P=0.277          P=0.505          P=0.440         |
|POLY 3             |        P=0.093N         P=0.237N         P=0.219N      |  P=0.304          P=0.501          P=0.466         |
|POLY 1.5           |        P=0.095N         P=0.238N         P=0.229N      |  P=0.311          P=0.498          P=0.475         |
|POLY 6             |        P=0.090N         P=0.238N         P=0.206N      |  P=0.303          P=0.510          P=0.463         |
|LOGISTIC REGRESSION|        P=0.090N         P=0.236N         P=0.229N      |  P=0.350          P=0.535          P=0.486         |
|COCH-ARM / FISHERS |        P=0.097N         P=0.247N         P=0.253N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/49 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.9%             2.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              567              674           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.456          P=0.270          P=0.577       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.411          P=0.241          P=0.520       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.386          P=0.239          P=0.509       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.452          P=0.245          P=0.537       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.378          P=0.238          P=0.526       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.355          P=0.247          P=0.495       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        1/49 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.0%             5.9%             2.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        712              630              703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.465N         P=0.530          P=0.617N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.590N         P=0.507          P=0.740N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.606N         P=0.503          P=0.751N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.561N         P=0.514          P=0.722N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.553N         P=0.507          P=0.690N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.616          P=0.500          P=0.747       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/49 (0%)     |  8/50 (16%)       2/50 (4%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        5.9%             0.0%             0.0%          |  21.3%            5.7%             13.0%           |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  2/15 (13%)       0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        469              ---              ---           |  423              545              394             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.069N         P=0.215N         P=0.174N      |  P=0.188N         P=0.053N         P=0.291N        |
|POLY 3             |        P=0.093N         P=0.239N         P=0.220N      |  P=0.157N         P=0.052N         P=0.278N        |
|POLY 1.5           |        P=0.095N         P=0.239N         P=0.230N      |  P=0.143N         P=0.052N         P=0.245N        |
|POLY 6             |        P=0.090N         P=0.239N         P=0.206N      |  P=0.164N         P=0.050N         P=0.302N        |
|LOGISTIC REGRESSION|        P=0.103N         P=0.237N         P=0.271N      |  P=0.101N         P=0.046N*        P=0.162N        |
|COCH-ARM / FISHERS |        P=0.097N         P=0.247N         P=0.253N      |  P=0.114N         P=0.046N*        P=0.178N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/49 (2%)     |  4/50 (8%)        4/50 (8%)        9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        6.0%             2.9%             2.7%          |  11.2%            11.2%            28.2%           |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  2/15 (13%)       2/18 (11%)       5/14 (36%)      |
|FIRST INCIDENCE    |        654              497              526           |  545              429              355             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.305N         P=0.481N         P=0.399N      |  P=0.046 *        P=0.605N         P=0.073         |
|POLY 3             |        P=0.357N         P=0.493N         P=0.464N      |  P=0.049 *        P=0.646          P=0.067         |
|POLY 1.5           |        P=0.369N         P=0.497N         P=0.483N      |  P=0.056          P=0.637          P=0.079         |
|POLY 6             |        P=0.337N         P=0.489N         P=0.436N      |  P=0.046 *        P=0.631N         P=0.061         |
|LOGISTIC REGRESSION|        P=0.414N         P=0.500N         P=0.508N      |  P=0.069          P=0.640          P=0.097         |
|COCH-ARM / FISHERS |        P=0.384N         P=0.500N         P=0.508N      |  P=0.078          P=0.643N         P=0.117         |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       2/50 (4%)        1/50 (2%)     |                                                    |
|POLY-3 ADJUSTED (b)|        23.4%            5.9%             2.7%          |                                                    |
|TERMINAL (d)       |        2/8 (25%)        0/10 (0%)        0/14 (0%)     |                                                    |
|FIRST INCIDENCE    |        653              611              713           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.002N**       P=0.049N*        P=0.003N**    |                                                    |
|POLY 3             |        P=0.003N**       P=0.038N*        P=0.009N**    |                                                    |
|POLY 1.5           |        P=0.004N**       P=0.042N*        P=0.011N*     |                                                    |
|POLY 6             |        P=0.002N**       P=0.034N*        P=0.006N**    |                                                    |
|LOGISTIC REGRESSION|        P=0.002N**       P=0.039N*        P=0.004N**    |                                                    |
|COCH-ARM / FISHERS |        P=0.006N**       P=0.046N*        P=0.015N*     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        32/50 (64%)      35/50 (70%)      38/50 (76%)   |                                                    |
|POLY-3 ADJUSTED (b)|        69.2%            79.1%            81.8%         |                                                    |
|TERMINAL (d)       |        4/8 (50%)        8/10 (80%)       13/14 (93%)   |                                                    |
|FIRST INCIDENCE    |        293              224              482           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.331N         P=0.458          P=0.382N      |                                                    |
|POLY 3             |        P=0.074          P=0.180          P=0.104       |                                                    |
|POLY 1.5           |        P=0.087          P=0.247          P=0.113       |                                                    |
|POLY 6             |        P=0.073          P=0.107          P=0.112       |                                                    |
|LOGISTIC REGRESSION|        P=0.091          P=0.328          P=0.085       |                                                    |
|COCH-ARM / FISHERS |        P=0.115          P=0.335          P=0.138       |                                                    |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 33

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        0/50 (0%)     |                                                    |
|POLY-3 ADJUSTED (b)|        3.0%             8.7%             0.0%          |                                                    |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |                                                    |
|FIRST INCIDENCE    |        728 (T)          567              ---           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.312N         P=0.310          P=0.388N      |                                                    |
|POLY 3             |        P=0.327N         P=0.318          P=0.478N      |                                                    |
|POLY 1.5           |        P=0.349N         P=0.311          P=0.487N      |                                                    |
|POLY 6             |        P=0.294N         P=0.332          P=0.463N      |                                                    |
|LOGISTIC REGRESSION|        P=0.362N         P=0.306          (e)           |                                                    |
|COCH-ARM / FISHERS |        P=0.378N         P=0.309          P=0.500N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      10/50 (20%)      7/50 (14%)    |                                                    |
|POLY-3 ADJUSTED (b)|        27.6%            26.8%            17.8%         |                                                    |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        2/14 (14%)    |                                                    |
|FIRST INCIDENCE    |        293              497              482           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.127N         P=0.575N         P=0.131N      |                                                    |
|POLY 3             |        P=0.187N         P=0.576N         P=0.227N      |                                                    |
|POLY 1.5           |        P=0.218N         P=0.595N         P=0.258N      |                                                    |
|POLY 6             |        P=0.144N         P=0.538N         P=0.183N      |                                                    |
|LOGISTIC REGRESSION|        P=0.281N         P=0.599          P=0.325N      |                                                    |
|COCH-ARM / FISHERS |        P=0.258N         P=0.598N         P=0.298N      |                                                    |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 34

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        3.0%             0.0%             5.3%          |                                                    |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |                                                    |
|FIRST INCIDENCE    |        706              ---              580           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.456          P=0.467N         P=0.613       |                                                    |
|POLY 3             |        P=0.388          P=0.499N         P=0.545       |                                                    |
|POLY 1.5           |        P=0.376          P=0.500N         P=0.525       |                                                    |
|POLY 6             |        P=0.411          P=0.498N         P=0.576       |                                                    |
|LOGISTIC REGRESSION|        P=0.376          P=0.488N         P=0.517       |                                                    |
|COCH-ARM / FISHERS |        P=0.360          P=0.500N         P=0.500       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |                                                    |
|POLY-3 ADJUSTED (b)|        0.0%             5.9%             0.0%          |                                                    |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |                                                    |
|FIRST INCIDENCE    |        ---              630              ---           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.594N         P=0.246          (e)           |                                                    |
|POLY 3             |        P=0.631N         P=0.240          (e)           |                                                    |
|POLY 1.5           |        P=0.647N         P=0.238          (e)           |                                                    |
|POLY 6             |        P=0.603N         P=0.244          (e)           |                                                    |
|LOGISTIC REGRESSION|        P=0.640N         P=0.240          (e)           |                                                    |
|COCH-ARM / FISHERS |        P=0.669          P=0.247          (e)           |                                                    |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 35

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland, Skin, Site of Application                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        45/50 (90%)      45/50 (90%)   |  2/50 (4%)        48/50 (96%)      49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        3.0%             94.9%            93.2%         |  5.7%             96.8%            100.0%          |
|TERMINAL (d)       |        0/8 (0%)         10/10 (100%)     13/14 (93%)   |  1/15 (7%)        18/18 (100%)     14/14 (100%)    |
|FIRST INCIDENCE    |        659              331              482           |  524              244              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        44/50 (88%)      40/50 (80%)   |  1/50 (2%)        38/50 (76%)      31/50 (62%)     |
|POLY-3 ADJUSTED (b)|        0.0%             91.0%            84.3%         |  2.9%             82.9%            77.7%           |
|TERMINAL (d)       |        0/8 (0%)         8/10 (80%)       10/14 (71%)   |  1/15 (7%)        14/18 (78%)      10/14 (71%)     |
|FIRST INCIDENCE    |        ---              224              482           |  728 (T)          244              302             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 36

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        49/50 (98%)      47/50 (94%)   |  3/50 (6%)        50/50 (100%)     50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        0.0%             98.6%            94.9%         |  8.5%             100.0%           100.0%          |
|TERMINAL (d)       |        0/8 (0%)         10/10 (100%)     12/14 (86%)   |  1/15 (7%)        18/18 (100%)     14/14 (100%)    |
|FIRST INCIDENCE    |        ---              224              482           |  524              244              169             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        48/50 (96%)      41/50 (82%)   |  2/50 (4%)        44/50 (88%)      48/50 (96%)     |
|POLY-3 ADJUSTED (b)|        0.0%             97.6%            85.4%         |  5.7%             89.8%            99.8%           |
|TERMINAL (d)       |        0/8 (0%)         10/10 (100%)     10/14 (71%)   |  1/15 (7%)        17/18 (94%)      14/14 (100%)    |
|FIRST INCIDENCE    |        ---              224              482           |  692              244              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 37

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Parakeratosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        10/50 (20%)      11/50 (22%)   |  2/50 (4%)        27/50 (54%)      43/50 (86%)     |
|POLY-3 ADJUSTED (b)|        0.0%             25.9%            27.7%         |  5.6%             62.2%            91.0%           |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        3/14 (21%)    |  0/15 (0%)        11/18 (61%)      13/14 (93%)     |
|FIRST INCIDENCE    |        ---              224              482           |  524              270              169             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.010 *        P=0.002 **       P=0.007 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P=0.003 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P=0.002 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P=0.006 **       P=0.002 **       P=0.002 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        7/50 (14%)       6/50 (12%)    |  3/50 (6%)        20/50 (40%)      36/50 (72%)     |
|POLY-3 ADJUSTED (b)|        0.0%             18.9%            15.6%         |  8.5%             48.6%            84.7%           |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  1/15 (7%)        10/18 (56%)      13/14 (93%)     |
|FIRST INCIDENCE    |        ---              440              535           |  524              270              302             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.071          P=0.012 *        P=0.061       |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P=0.043 *        P=0.010 *        P=0.023 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P=0.033 *        P=0.009 **       P=0.019 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P=0.066          P=0.013 *        P=0.031 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.018 *        P=0.009 **       P=0.023 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.025 *        P=0.006 **       P=0.013 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 38

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       6/50 (12%)       5/50 (10%)    |  3/50 (6%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        17.2%            17.1%            13.3%         |  8.6%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        2/14 (14%)    |  2/15 (13%)       0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        608              621              611           |  698              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.230N         P=0.610          P=0.274N      |  P=0.036N*        P=0.093N         P=0.137N        |
|POLY 3             |        P=0.378N         P=0.622N         P=0.443N      |  P=0.043N*        P=0.119N         P=0.154N        |
|POLY 1.5           |        P=0.402N         P=0.622N         P=0.465N      |  P=0.041N*        P=0.122N         P=0.143N        |
|POLY 6             |        P=0.345N         P=0.623N         P=0.412N      |  P=0.043N*        P=0.113N         P=0.160N        |
|LOGISTIC REGRESSION|        P=0.346N         P=0.616N         P=0.403N      |  P=0.039N*        P=0.099N         P=0.144N        |
|COCH-ARM / FISHERS |        P=0.437N         P=0.620N         P=0.500N      |  P=0.037N*        P=0.121N         P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        6/50 (12%)       3/50 (6%)     |  1/50 (2%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        5.8%             16.5%            7.9%          |  2.9%             0.0%             3.5%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        440              497              526           |  698              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.527          P=0.145          P=0.625       |  P=0.655          P=0.469N         P=0.740         |
|POLY 3             |        P=0.508          P=0.146          P=0.550       |  P=0.669          P=0.503N         P=0.718         |
|POLY 1.5           |        P=0.471          P=0.139          P=0.528       |  P=0.666          P=0.505N         P=0.731         |
|POLY 6             |        P=0.568          P=0.161          P=0.584       |  P=0.673          P=0.497N         P=0.710         |
|LOGISTIC REGRESSION|        P=0.346          P=0.135          P=0.417       |  P=0.637          P=0.494N         P=0.725         |
|COCH-ARM / FISHERS |        P=0.424          P=0.134          P=0.500       |  P=0.669          P=0.500N         P=0.753N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 39

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       6/50 (12%)       3/50 (6%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        14.7%            16.7%            7.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/8 (25%)        0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        638              580              591           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.194N         P=0.499          P=0.203N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.235N         P=0.538          P=0.295N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.263N         P=0.517          P=0.321N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.196N         P=0.574          P=0.259N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.278N         P=0.503          P=0.287N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.303N         P=0.500          P=0.357N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/50 (28%)      26/50 (52%)      11/50 (22%)   |  1/50 (2%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        38.4%            59.4%            27.8%         |  2.9%             2.9%             3.5%            |
|TERMINAL (d)       |        2/8 (25%)        0/10 (0%)        3/14 (21%)    |  0/15 (0%)        1/18 (6%)        1/14 (7%)       |
|FIRST INCIDENCE    |        549              440              497           |  695              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.110N         P=0.042 *        P=0.093N      |  P=0.618          P=0.735N         P=0.735         |
|POLY 3             |        P=0.154N         P=0.040 *        P=0.221N      |  P=0.604          P=0.758          P=0.718         |
|POLY 1.5           |        P=0.201N         P=0.021 *        P=0.259N      |  P=0.613          P=0.756          P=0.731         |
|POLY 6             |        P=0.115N         P=0.099          P=0.182N      |  P=0.602          P=0.760N         P=0.710         |
|LOGISTIC REGRESSION|        P=0.286N         P=0.012 *        P=0.226N      |  P=0.602          P=0.749N         P=0.723         |
|COCH-ARM / FISHERS |        P=0.299N         P=0.012 *        P=0.322N      |  P=0.640          P=0.753N         P=0.753N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 40

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia Basal Cell                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.0%             2.9%             5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        694              591              618           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.500N         P=0.497N         P=0.563N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.581N         P=0.495N         P=0.654N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.594N         P=0.498N         P=0.671N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.561N         P=0.491N         P=0.626N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.564N         P=0.496N         P=0.625N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.610          P=0.500N         P=0.691N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        8.9%             8.6%             2.7%          |  0.0%             2.9%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        654              483              636           |  ---              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.177N         P=0.651          P=0.212N      |  P=0.729          P=0.536          (e)             |
|POLY 3             |        P=0.200N         P=0.649N         P=0.267N      |  P=0.698          P=0.498          (e)             |
|POLY 1.5           |        P=0.217N         P=0.656N         P=0.283N      |  P=0.707          P=0.496          (e)             |
|POLY 6             |        P=0.177N         P=0.640N         P=0.244N      |  P=0.694          P=0.504          (e)             |
|LOGISTIC REGRESSION|        P=0.240N         P=0.663N         P=0.260N      |  (e)              P=0.536          (e)             |
|COCH-ARM / FISHERS |        P=0.238N         P=0.661N         P=0.309N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 41

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        12/50 (24%)      23/50 (46%)      11/50 (22%)   |  1/50 (2%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        33.2%            54.8%            27.4%         |  2.9%             2.9%             3.5%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        3/14 (21%)    |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        549              497              497           |  695              635              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.203N         P=0.047 *        P=0.212N      |  P=0.591          P=0.758          P=0.735         |
|POLY 3             |        P=0.279N         P=0.037 *        P=0.380N      |  P=0.605          P=0.761          P=0.718         |
|POLY 1.5           |        P=0.346N         P=0.024 *        P=0.428N      |  P=0.613          P=0.757          P=0.731         |
|POLY 6             |        P=0.210N         P=0.077          P=0.323N      |  P=0.603          P=0.755N         P=0.710         |
|LOGISTIC REGRESSION|        P=0.438N         P=0.018 *        P=0.434N      |  P=0.590          P=0.761          P=0.723         |
|COCH-ARM / FISHERS |        P=0.457N         P=0.018 *        P=0.500N      |  P=0.640          P=0.753N         P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        3/50 (6%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.9%             3.0%             8.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        638              630              677           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.566          P=0.531N         P=0.660N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.438          P=0.498N         P=0.549       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.421          P=0.500N         P=0.528       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.466          P=0.497N         P=0.583       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.469          P=0.497N         P=0.594       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.399          P=0.500N         P=0.500       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 42

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.3%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              ---              576           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.132          (e)              P=0.313       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.106          (e)              P=0.265       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.101          (e)              P=0.253       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.116          (e)              P=0.286       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.102          (e)              P=0.248       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Perforation                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        10/50 (20%)      1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        11.8%            26.9%            2.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        638              580              535           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.138N         P=0.081          P=0.109N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.124N         P=0.092          P=0.145N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.152N         P=0.080          P=0.159N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.090N         P=0.118          P=0.126N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.201N         P=0.075          P=0.160N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.202N         P=0.074          P=0.181N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 43

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      14/50 (28%)      7/50 (14%)    |  1/50 (2%)        5/50 (10%)       2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        27.7%            35.4%            17.9%         |  2.9%             14.0%            6.9%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        549              483              497           |  718              547              644             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.144N         P=0.263          P=0.141N      |  P=0.341          P=0.134          P=0.460         |
|POLY 3             |        P=0.179N         P=0.315          P=0.224N      |  P=0.306          P=0.104          P=0.438         |
|POLY 1.5           |        P=0.211N         P=0.277          P=0.251N      |  P=0.334          P=0.099          P=0.455         |
|POLY 6             |        P=0.147N         P=0.376          P=0.194N      |  P=0.297          P=0.119          P=0.432         |
|LOGISTIC REGRESSION|        P=0.296N         P=0.241          P=0.278N      |  P=0.335          P=0.100          P=0.428         |
|COCH-ARM / FISHERS |        P=0.268N         P=0.241          P=0.298N      |  P=0.412          P=0.102          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/50 (28%)      25/50 (50%)      13/50 (26%)   |  1/50 (2%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        38.4%            58.1%            32.4%         |  2.9%             2.9%             3.5%            |
|TERMINAL (d)       |        2/8 (25%)        0/10 (0%)        4/14 (29%)    |  0/15 (0%)        1/18 (6%)        1/14 (7%)       |
|FIRST INCIDENCE    |        549              440              497           |  695              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.182N         P=0.056          P=0.173N      |  P=0.618          P=0.735N         P=0.735         |
|POLY 3             |        P=0.281N         P=0.053          P=0.374N      |  P=0.604          P=0.758          P=0.718         |
|POLY 1.5           |        P=0.345N         P=0.031 *        P=0.424N      |  P=0.613          P=0.756          P=0.731         |
|POLY 6             |        P=0.219N         P=0.118          P=0.318N      |  P=0.602          P=0.760N         P=0.710         |
|LOGISTIC REGRESSION|        P=0.427N         P=0.020 *        P=0.388N      |  P=0.602          P=0.749N         P=0.723         |
|COCH-ARM / FISHERS |        P=0.458N         P=0.020 *        P=0.500N      |  P=0.640          P=0.753N         P=0.753N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 44

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/50 (26%)      6/49 (12%)       8/50 (16%)    |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        36.4%            17.4%            21.0%         |  0.0%             0.0%             3.5%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        2/14 (14%)    |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        608              580              576           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.029N*        P=0.073N         P=0.033N*     |  P=0.253          (e)              P=0.486         |
|POLY 3             |        P=0.080N         P=0.055N         P=0.104N      |  P=0.282          (e)              P=0.463         |
|POLY 1.5           |        P=0.095N         P=0.061N         P=0.126N      |  P=0.277          (e)              P=0.474         |
|POLY 6             |        P=0.062N         P=0.053N         P=0.082N      |  P=0.287          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.051N         P=0.053N         P=0.065N      |  (e)              (e)              P=0.486         |
|COCH-ARM / FISHERS |        P=0.121N         P=0.068N         P=0.163N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/49 (2%)        0/50 (0%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.0%             3.0%             0.0%          |  2.8%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        614              653              ---           |  579              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.108N         P=0.496N         P=0.168N      |  P=0.320N         P=0.517N         P=0.581N        |
|POLY 3             |        P=0.130N         P=0.502N         P=0.215N      |  P=0.305N         P=0.505N         P=0.540N        |
|POLY 1.5           |        P=0.135N         P=0.505N         P=0.224N      |  P=0.294N         P=0.506N         P=0.528N        |
|POLY 6             |        P=0.121N         P=0.498N         P=0.201N      |  P=0.311N         P=0.501N         P=0.548N        |
|LOGISTIC REGRESSION|        P=0.124N         P=0.499N         P=0.206N      |  P=0.255N         P=0.489N         P=0.488N        |
|COCH-ARM / FISHERS |        P=0.143N         P=0.508N         P=0.247N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 45

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        16/50 (32%)      14/50 (28%)      11/50 (22%)   |                                                    |
|POLY-3 ADJUSTED (b)|        43.4%            37.2%            28.2%         |                                                    |
|TERMINAL (d)       |        4/8 (50%)        2/10 (20%)       4/14 (29%)    |                                                    |
|FIRST INCIDENCE    |        549              497              580           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.039N*        P=0.402N         P=0.037N*     |                                                    |
|POLY 3             |        P=0.096N         P=0.373N         P=0.118N      |                                                    |
|POLY 1.5           |        P=0.118N         P=0.394N         P=0.142N      |                                                    |
|POLY 6             |        P=0.072N         P=0.349N         P=0.092N      |                                                    |
|LOGISTIC REGRESSION|        P=0.089N         P=0.403N         P=0.090N      |                                                    |
|COCH-ARM / FISHERS |        P=0.156N         P=0.414N         P=0.184N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       5/50 (10%)    |                                                    |
|POLY-3 ADJUSTED (b)|        11.6%            17.1%            13.1%         |                                                    |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       1/14 (7%)     |                                                    |
|FIRST INCIDENCE    |        549              549              580           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.500N         P=0.387          P=0.574N      |                                                    |
|POLY 3             |        P=0.512          P=0.377          P=0.564       |                                                    |
|POLY 1.5           |        P=0.479          P=0.372          P=0.537       |                                                    |
|POLY 6             |        P=0.565          P=0.385          P=0.606       |                                                    |
|LOGISTIC REGRESSION|        P=0.476          P=0.371          P=0.536       |                                                    |
|COCH-ARM / FISHERS |        P=0.434          P=0.370          P=0.500       |                                                    |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 46

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        28/50 (56%)      23/50 (46%)      20/50 (40%)   |                                                    |
|POLY-3 ADJUSTED (b)|        63.1%            54.7%            44.5%         |                                                    |
|TERMINAL (d)       |        2/8 (25%)        4/10 (40%)       2/14 (14%)    |                                                    |
|FIRST INCIDENCE    |        293              331              482           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.036N*        P=0.275N         P=0.046N*     |                                                    |
|POLY 3             |        P=0.040N*        P=0.271N         P=0.052N      |                                                    |
|POLY 1.5           |        P=0.049N*        P=0.246N         P=0.062N      |                                                    |
|POLY 6             |        P=0.031N*        P=0.321N         P=0.043N*     |                                                    |
|LOGISTIC REGRESSION|        P=0.129N         P=0.211N         P=0.179N      |                                                    |
|COCH-ARM / FISHERS |        P=0.067N         P=0.212N         P=0.080N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/45 (2%)        0/42 (0%)        2/44 (5%)     |  0/47 (0%)        0/46 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.3%             0.0%             6.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/6 (0%)         0/7 (0%)         1/14 (7%)     |  0/14 (0%)        0/16 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        603              ---              618           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.463          P=0.500N         P=0.617       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.385          P=0.517N         P=0.537       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.371          P=0.516N         P=0.517       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.410          P=0.517N         P=0.571       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.376          P=0.512N         P=0.512       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.355          P=0.517N         P=0.491       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 47

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Ultimobranchial Cyst                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.0%             2.9%             0.0%          |  5.6%             2.8%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        613              224              ---           |  497              244              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.325N         P=0.746          P=0.483N      |  P=0.160N         P=0.488N         P=0.276N        |
|POLY 3             |        P=0.313N         P=0.757N         P=0.480N      |  P=0.187N         P=0.503N         P=0.286N        |
|POLY 1.5           |        P=0.321N         P=0.757N         P=0.488N      |  P=0.173N         P=0.505N         P=0.270N        |
|POLY 6             |        P=0.301N         P=0.757N         P=0.468N      |  P=0.196N         P=0.494N         P=0.296N        |
|LOGISTIC REGRESSION|        P=0.457N         P=0.722N         P=0.519N      |  P=0.068N         P=0.393N         P=0.232N        |
|COCH-ARM / FISHERS |        P=0.331N         P=0.753N         P=0.500N      |  P=0.142N         P=0.500N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             8.8%             2.7%          |  2.9%             2.9%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/10 (10%)       1/14 (7%)     |  0/15 (0%)        1/18 (6%)        0/14 (0%)       |
|FIRST INCIDENCE    |        ---              611              728 (T)       |  635              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.497          P=0.131          P=0.612       |  P=0.371N         P=0.748N         P=0.568N        |
|POLY 3             |        P=0.442          P=0.121          P=0.522       |  P=0.402N         P=0.757          P=0.539N        |
|POLY 1.5           |        P=0.414          P=0.120          P=0.513       |  P=0.380N         P=0.755          P=0.527N        |
|POLY 6             |        P=0.487          P=0.125          P=0.537       |  P=0.416N         P=0.762N         P=0.546N        |
|LOGISTIC REGRESSION|        P=0.439          P=0.122          P=0.612       |  P=0.369N         P=0.763N         P=0.522N        |
|COCH-ARM / FISHERS |        P=0.378          P=0.121          P=0.500       |  P=0.331N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 48

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Trachea                                                                                                                          |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        5.9%             0.0%             0.0%          |  0.0%             2.9%             3.4%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        542              ---              ---           |  ---              662              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.089N         P=0.249N         P=0.216N      |  P=0.276          P=0.515          P=0.440         |
|POLY 3             |        P=0.092N         P=0.240N         P=0.218N      |  P=0.303          P=0.499          P=0.466         |
|POLY 1.5           |        P=0.093N         P=0.239N         P=0.226N      |  P=0.310          P=0.496          P=0.475         |
|POLY 6             |        P=0.089N         P=0.243N         P=0.206N      |  P=0.303          P=0.507          P=0.463         |
|LOGISTIC REGRESSION|        P=0.103N         P=0.236N         P=0.274N      |  P=0.306          P=0.498          P=0.486         |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/49 (6%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/49 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        8.6%             2.9%             2.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/14 (0%)     |  0/15 (0%)        0/18 (0%)        0/14 (0%)       |
|FIRST INCIDENCE    |        473              440              631           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.187N         P=0.302N         P=0.276N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.184N         P=0.308N         P=0.277N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.190N         P=0.304N         P=0.286N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.174N         P=0.316N         P=0.262N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.268N         P=0.251N         P=0.436N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.196N         P=0.301N         P=0.301N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  08/13/97                           EXPERIMENT: 91014 TEST: 03                                            Page 49

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   OLEIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        1/49 (2%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        5.9%             5.8%             2.7%          |  0.0%             2.9%             6.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        1/14 (7%)     |  0/15 (0%)        0/18 (0%)        1/14 (7%)       |
|FIRST INCIDENCE    |        473              440              728 (T)       |  ---              541              170             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.330N         P=0.670          P=0.413N      |  P=0.122          P=0.505          P=0.230         |
|POLY 3             |        P=0.358N         P=0.689N         P=0.468N      |  P=0.123          P=0.497          P=0.200         |
|POLY 1.5           |        P=0.369N         P=0.688N         P=0.478N      |  P=0.127          P=0.493          P=0.209         |
|POLY 6             |        P=0.341N         P=0.690N         P=0.452N      |  P=0.123          P=0.507          P=0.197         |
|LOGISTIC REGRESSION|        P=0.431N         P=0.673N         P=0.519N      |  P=0.211          P=0.523          P=0.356         |
|COCH-ARM / FISHERS |        P=0.383N         P=0.684N         P=0.492N      |  P=0.139          P=0.495          P=0.242         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100MG/KG      |  0 MG/KG          50 MG/KG         100MG/KG        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/50 (0%)        4/50 (8%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             11.4%            6.6%            |
|TERMINAL (d)       |                                                        |  0/15 (0%)        2/18 (11%)       0/14 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              524              305             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.191          P=0.086          P=0.216         |
|POLY 3             |                                                        |  P=0.168          P=0.059          P=0.208         |
|POLY 1.5           |                                                        |  P=0.181          P=0.058          P=0.216         |
|POLY 6             |                                                        |  P=0.166          P=0.064          P=0.207         |
|LOGISTIC REGRESSION|                                                        |  P=0.254          P=0.061          P=0.485         |
|COCH-ARM / FISHERS |                                                        |  P=0.222          P=0.059          P=0.247         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).