Statistical Analysis Of Survival Data
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus OLEIC ACID DIETHANOLAMINE CONDENSATE DATE: 11/14/97
EXPERIMENT: 91014 TEST: 03 TIME: 13:49:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: C91014
PATHOLOGIST: YARRINGTON, J. CAS: 93-83-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus OLEIC ACID DIETHANOLAMINE CONDENSATE DATE: 11/14/97
EXPERIMENT: 91014 TEST: 03 TIME: 13:49:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: C91014
PATHOLOGIST: YARRINGTON, J. CAS: 93-83-4
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 293 440 440 469 473 495 506 517 530 542 |
| 549 571 574 580 598 603 608 613 614 618 |
| 623 634 637 638 638 638 647 653 653 654 |
| 654 654 659 674 678 694 699 700 700 706 |
| 707 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 224 331 440 483 497 528 549 551 554 567 |
| 580 580 580 591 603 603 607 611 611 611 |
| 612 615 621 623 630 636 637 638 638 653 |
| 653 654 659 668 674 696 699 706 707 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 482 497 502 526 529 532 535 549 554 576 |
| 580 580 591 611 618 628 631 636 638 638 |
| 638 638 644 647 661 674 676 676 677 696 |
| 703 703 710 713 723 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 90.0 80.0 68.0 34.0 16.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 98.0 96.0 96.0 92.0 88.0 68.0 34.0 20.0 |
| | |
| | |
|100MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 86.0 74.0 50.0 28.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.0% 20.0% 28.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.125N P=0.949N P=0.127N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.0 596.2 620.5 |
|NATURAL DEATHS (C) | (13.9) (15.3) (11.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 622.2 622.5 650.6 |
|(STANDARD ERROR) | (13.4) (14.4) (10.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 296 423 429 437 447 462 462 497 513 524 |
| 529 545 560 571 579 586 602 610 614 635 |
| 635 635 641 641 653 668 676 679 692 694 |
| 695 696 698 706 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 244 270 284 289 371 397 429 508 524 528 |
| 541 541 544 545 546 547 567 579 622 623 |
| 630 635 658 662 667 674 685 685 693 702 |
| 719 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 169 170 302 305 313 331 355 356 394 419 |
| 434 459 463 501 518 518 519 526 535 535 |
| 549 560 561 563 568 574 595 621 637 644 |
| 673 681 692 695 709 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 96.0 86.0 76.0 66.0 50.0 30.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 96.0 92.0 88.0 86.0 72.0 64.0 52.0 36.0 |
| | |
| | |
|100MG/KG | 100.0 96.0 96.0 84.0 80.0 74.0 60.0 46.0 40.0 28.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 30.0% 36.0% 28.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.380 P=0.802N P=0.400 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 584.2 551.0 504.7 |
|NATURAL DEATHS (C) | (17.5) (24.6) (24.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 627.4 614.7 567.2 |
|(STANDARD ERROR) | (15.4) (19.8) (22.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OLEIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 1 2 1 3 3
| 2 1 1 2 33 3
| 112 2
90 + 1 1 2
| 1 1 23 2
| 11 13 22
| 1 1 22 3
80 + 11 2 2
| 1 1
P | 11 2 3
E | 1 21233
R 70 + 11 33
C | 33
E | 11 33
N | 11
T 60 +
| 1 1
S | 22 113
U | 22 3 3
R 50 + 22 3 3
V | 11
I | 2211
V | 2 2 3 3
A 40 + 33
L |
| 1 121 33
| 22 3 3
30 + 1 1
| 3
| 22
| 11 2
20 + 2
| 11
| 1 1
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.
OLEIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 2 1
| 2 2 1 1
96 + 3 2 2 3 11
| 22 11
| 2 3 3 2 11
| 3 3 2 2 1 1
88 + 3 3 2 2
| 2 1 1 2
| 3 3 1 21 2
| 3 3 1 12
P 80 + 3 3 11 2
E | 3 3 1 1
R | 33 1 1
C | 3 3 1 1
E 72 + 3 3 11
N | 22 11
T | 3 3 2 2 1 1
| 33 2 2 1 1
S 64 + 33 2 2
U | 1 1
R | 3 3 22
V | 33 22
I 56 + 33 11 2
V | 2 2
A | 33 1 1 22
L | 1 12
48 + 3 3 112
| 3 3
| 3 3 121
| 33 112
40 + 3 3 2 2
| 33 22
| 33 2
| 311
32 + 3131
| 311
| 3
|
24 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.