National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10618

Oleic Acid Diethamolamine Condensate

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:26:34

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  C91014

       CONTRACT NUMBER:  N01-ES-15314

       CAS NUMBER:  93-83-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:    235         FIRST DOSE: 05/11/93
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 4                      ROOM/AREA:    235         FIRST DOSE: 05/11/93
            SEX: FEMALE                               TRT: 15 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 6                      ROOM/AREA:    235         FIRST DOSE: 05/11/93
            SEX: FEMALE                               TRT: 30 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

307         307  638 02/07/95   638 02/07/95   1/24  Irritation Site of Applic

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:    235         FIRST DOSE: 05/10/93
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 3                      ROOM/AREA:    235         FIRST DOSE: 05/10/93
            SEX: MALE                                 TRT: 15 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

107         107   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

NTP  EXP/TEST: 91014-04                       OLEIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/23/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:26:34
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 5                      ROOM/AREA:    235         FIRST DOSE: 05/10/93
            SEX: MALE                                 TRT: 30 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

116         116   78 07/26/93   106 08/23/93   2/26  Irritation Site of Applic

118         118   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

120         120   78 07/26/93    78 07/26/93   1/23  Irritation Site of Applic

124         124  470 08/22/94   470 08/22/94   1/17  Irritation Site of Applic

127         127   78 07/26/93   106 08/23/93   2/12  Irritation Site of Applic

129         129   78 07/26/93    78 07/26/93   1/20  Irritation Site of Applic

133         133   78 07/26/93    78 07/26/93   1/3   Irritation Site of Applic

138         138  638 02/06/95   638 02/06/95   1/23  Irritation Site of Applic

140         140  106 08/23/93   106 08/23/93   1/20  Irritation Site of Applic

141         141   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

143         143   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

145         145   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

147         147   78 07/26/93   582 12/12/94   3/21  Irritation Site of Applic

149         149   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

150         150   78 07/26/93    78 07/26/93   1/26  Irritation Site of Applic

159         159   78 07/26/93    78 07/26/93   1/3   Irritation Site of Applic

161         161   78 07/26/93    78 07/26/93   1/15  Irritation Site of Applic

162         162   78 07/26/93    78 07/26/93   1/3   Irritation Site of Applic

163         163   78 07/26/93    78 07/26/93   1/3   Irritation Site of Applic

164         164  106 08/23/93   106 08/23/93   1/23  Irritation Site of Applic



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