National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10622

Incidence Rates of Nonneoplastic Lesions by Anatomic Site

NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97
Route: SKIN APPLICATION                                                                                           Time: 09:32:07

                                                          14 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    15 MG/KG
                               Include 006    30 MG/KG
                               Include 001    0 MG/KG
                               Include 003    15 MG/KG
                               Include 005    30 MG/KG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:32:07  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          55           55           55                                                  

  Scheduled Sacrifice                                  5            5            5                                                  
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5            5                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (1)                                                                           
      Follicle, Cyst                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (5)          (5)          (5)                                                 
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                              4 (80%)      4 (80%)                                            
      Epidermis, Skin, Site of Application,                                                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:32:07  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Hyperplasia                                               5 (100%)     4 (80%)                                            
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              5 (100%)     5 (100%)                                           
      Skin, Site of Application, Hyperkeratosis                     2 (40%)      3 (60%)                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:32:07  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          55           55           55                                                  

  Scheduled Sacrifice                                  5            5            5                                                  
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5            5                                                  
   Skin                                               (5)          (5)          (5)                                                 
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                              5 (100%)     5 (100%)                                           
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               5 (100%)     5 (100%)                                           
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                              1 (20%)                                            
      Epidermis, Skin, Site of Application,                                                                                         
          Parakeratosis                                             1 (20%)      4 (80%)                                            
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              5 (100%)     5 (100%)                                           
      Skin, Site of Application, Hyperkeratosis                     4 (80%)      4 (80%)                                            
      Skin, Site of Application, Ulcer                                           1 (20%)                                            
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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