Incidence Rates of Nonneoplastic Lesions by Anatomic Site
NTP Experiment-Test: 91014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97
Route: SKIN APPLICATION Time: 09:32:07
14 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-83-4
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 15 MG/KG
Include 006 30 MG/KG
Include 001 0 MG/KG
Include 003 15 MG/KG
Include 005 30 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 91014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97
Route: SKIN APPLICATION Time: 09:32:07
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B6C3F1 MICE FEMALE 0 MG/KG 15 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 55 55 55
Scheduled Sacrifice 5 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5 5
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (1)
Follicle, Cyst 1 (100%)
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HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
Skin (5) (5) (5)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 4 (80%) 4 (80%)
Epidermis, Skin, Site of Application,
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 91014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97
Route: SKIN APPLICATION Time: 09:32:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 15 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 5 (100%) 4 (80%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 5 (100%) 5 (100%)
Skin, Site of Application, Hyperkeratosis 2 (40%) 3 (60%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 91014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97
Route: SKIN APPLICATION Time: 09:32:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 15 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 55 55 55
Scheduled Sacrifice 5 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5 5
Skin (5) (5) (5)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 5 (100%) 5 (100%)
Epidermis, Skin, Site of Application,
Hyperplasia 5 (100%) 5 (100%)
Epidermis, Skin, Site of Application,
Inflammation, Suppurative 1 (20%)
Epidermis, Skin, Site of Application,
Parakeratosis 1 (20%) 4 (80%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 5 (100%) 5 (100%)
Skin, Site of Application, Hyperkeratosis 4 (80%) 4 (80%)
Skin, Site of Application, Ulcer 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
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