National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3159

TDMS Study 92012-05 Pathology Tables

NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53

                                                          27 WEEK SSAC




       Facility:  Southern Research Institute

       Chemical CAS #:  693-98-1

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0PPM         1000 PPM     2500 PPM     5000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatodiaphragmatic Nodule                       1                         1                                                  
      Inflammation, Granulomatous                     10 [1.1]     10 [1.3]     10 [1.5]     10 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                                                       1 [1.0]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              1 [1.0]      2 [1.0]                   1 [1.0]                               
      Pars Distalis, Mitotic Alteration                1 [1.0]      2 [2.0]      2 [1.5]      2 [2.0]                               
      Pars Intermedia, Cyst                                         1 [1.0]      1 [2.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Mineralization, Focal                  1 [1.0]      6 [1.0]     10 [1.0]     10 [1.0]                               
      Follicular Cell, Hyperplasia                                  5 [1.6]     10 [1.7]     10 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0PPM         1000 PPM     2500 PPM     5000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 [3.0]                   1 [3.0]                                            
      Periovarian Tissue, Cyst                         1 [3.0]                                                                      
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Hydrometra                                       1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (3)          (4)          (1)          (3)                                    
      Mediastinal, Hemorrhage                          1 [3.0]      1 [3.0]                   2 [2.5]                               
      Pancreatic, Hemorrhage                                        2 [3.0]                   1 [3.0]                               
      Pancreatic, Hyperplasia, Lymphoid                2 [2.5]      1 [2.0]      1 [3.0]                                            
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Accessory Spleen                                                           1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Cyst Epithelial Inclusion                                                  1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (10)         (10)         (10)         (10)                                   
      Retrobulbar, Inflammation, Focal                              1 [1.0]                                                         
   Harderian Gland                                    (10)         (10)         (10)         (10)                                   
      Hyperplasia, Focal, Lymphoid                                                            1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0PPM         1000 PPM     2500 PPM     5000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Inflammation, Focal, Granulomatous                                         1 [2.0]      5 [1.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 [2.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0PPM         300 PPM      1000 PPM     3000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatodiaphragmatic Nodule                       2                         1                                                  
      Hyperplasia, Focal, Mast Cell                                              1 [2.0]                                            
      Infiltration Cellular, Focal,                                                                                                 
        Polymorphonuclear                                                        1 [2.0]                                            
      Inflammation, Granulomatous                      9 [1.0]      7 [1.0]     10 [1.0]     10 [1.0]                               
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 [4.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                                                       2 [2.0]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              1 [2.0]      2 [1.5]                   1 [2.0]                               
      Pars Distalis, Mitotic Alteration                             1 [1.0]      1 [1.0]                                            
      Pars Distalis, Vacuolization Cytoplasmic,                                                                                     
         Focal                                                                                1 [1.0]                               
      Pars Intermedia, Cyst                                                                   2 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Mineralization, Focal                  1 [1.0]      4 [1.0]      9 [1.0]      9 [2.8]                               
      Follicular Cell, Hyperplasia                                  7 [1.1]     10 [1.0]     10 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0PPM         300 PPM      1000 PPM     3000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)          (1)          (1)                                    
      Mediastinal, Hemorrhage                                       1 [3.0]                   1 [3.0]                               
      Pancreatic, Hemorrhage                                                     1 [3.0]                                            
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                                              1 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Accessory Spleen                                              2 [2.0]                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                    1 [2.0]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 14:17:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0PPM         300 PPM      1000 PPM     3000 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Harderian Gland                                    (10)         (10)         (10)         (10)                                   
      Inflammation, Focal, Granulomatous               1 [1.0]                                                                      
      Necrosis, Focal                                  1 [2.0]                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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