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TDMS Study 92012-05 Pathology Tables

NTP  EXP/TEST: 92012-05                                2-METHYLIMIDAZOLE                                          PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 02/24/03
ROUTE: DOSED FEED                                                                                                 TIME: 13:44:08

                                                         EIS REPORT 03


       FACILITY:  Southern Research Institute

       NTP C#:  92012B

       CONTRACT NUMBER:  N01-ES-85420

       CAS NUMBER:  693-98-1

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 92012-05                                2-METHYLIMIDAZOLE                                          PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 02/24/03
ROUTE: DOSED FEED                                           EISRPT03                                              TIME: 13:44:08
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 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 106    FIRST DOSE: 07/15/98
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0PPM               60     98.5    6.5        40    320.6   24.7                     40    221.5   21.5

 1000 PPM           60     99.2    5.9        39    308.5   23.4        96.2         39    208.0   21.9

 2500 PPM           60     98.2    6.9        28    283.1   23.3        88.3         28    184.4   21.9

 5000 PPM           60     97.7    6.5        41    227.9   24.4        71.0         41    130.3   26.1




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 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 106    FIRST DOSE: 07/15/98
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0PPM               60    114.4   11.5        34    414.7   31.0                     34    300.4   31.6

 300 PPM            60    112.7   11.3        39    416.0   23.3       100.3         39    302.6   24.2

 1000 PPM           60    113.5   10.8        35    406.7   26.3        98.0         35    292.9   21.2

 3000 PPM           60    113.2   10.5        35    375.2   35.1        90.4         35    260.5   36.2

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