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TDMS Study 92012-05 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                            2-METHYLIMIDAZOLE                                            DATE: 02/24/03  
EXPERIMENT: 92012 TEST: 05                                                                                        TIME: 13:42:55    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C92012B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      2-METHYLIMIDAZOLE                                           DATE: 02/24/03    
EXPERIMENT: 92012 TEST: 05                                                                                        TIME: 13:56:15    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  92012B      
CONT: N01-ES-85420                                                                                                CAS: 693-98-1     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                          
==================================================================================================================================  
            0PPM                      300 PPM                            1000 PPM                           3000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4    18.7   212.8      18.5    207.2    0.99       27     18.1    209.0    0.97       87     15.8    193.3    0.84      246       
  8    18.0   284.1      16.9    279.9    0.94       18     18.0    280.4    1.00       64     16.2    256.9    0.90      189       
 12    16.6   320.1      16.8    314.9    1.01       16     16.1    314.8    0.97       51     15.2    288.6    0.92      158       
 16    16.9   347.8      16.9    343.6    1.00       15     17.0    341.3    1.01       50     15.6    318.1    0.92      147       
 20    16.6   366.6      16.5    359.8    0.99       14     16.6    359.6    1.00       46     15.1    334.0    0.91      136       
 24    16.6   378.4      16.0    371.0    0.96       13     15.8    369.4    0.95       43     15.5    347.0    0.93      134       
 28    15.5   385.8      15.9    382.0    1.03       12     15.7    376.6    1.01       42     14.1    361.5    0.91      117       
 32    16.5   401.4      16.6    395.1    1.01       13     16.3    391.9    0.99       42     16.7    376.7    1.01      133       
 36    16.6   414.6      16.7    405.3    1.01       12     15.8    402.6    0.95       39     16.3    387.5    0.98      126       
 40    16.8   422.1      16.9    418.7    1.01       12     16.8    414.3    1.00       41     15.7    399.5    0.93      118       
 44    16.2   428.6      17.0    423.4    1.05       12     16.9    420.7    1.04       40     16.3    405.7    1.01      121       
 48    16.3   436.0      15.7    428.2    0.96       11     15.9    425.9    0.98       37     15.4    410.5    0.94      112       
 52    15.7   437.4      16.2    434.9    1.03       11     16.1    431.6    1.03       37     15.3    414.2    0.97      111       
 56    16.6   444.0      16.8    437.1    1.01       11     16.2    432.3    0.98       37     16.1    416.7    0.97      116       
 60    16.9   445.6      17.3    438.4    1.02       12     16.8    435.2    0.99       39     16.4    419.7    0.97      117       
 64    16.3   444.0      16.2    439.8    0.99       11     16.2    433.0    0.99       37     15.2    413.4    0.93      110       
 72    15.8   446.9      16.4    439.2    1.04       11     15.6    436.5    0.99       36     14.9    422.1    0.94      106       
 76    15.9   443.1      15.7    442.7    0.99       11     15.3    434.8    0.96       35     14.6    419.9    0.92      104       
 80    15.7   439.5      15.9    432.5    1.01       11     15.6    429.7    0.99       36     15.3    409.8    0.97      112       
 84    15.0   435.9      15.1    431.1    1.01       11     15.2    425.2    1.01       36     15.1    406.5    1.01      111       
 88    14.3   431.4      15.3    428.8    1.07       11     15.2    421.5    1.06       36     14.8    400.1    1.03      111       
 92    13.4   421.5      14.1    425.1    1.05       10     14.2    415.8    1.06       34     14.1    400.0    1.05      105       
 96    14.7   421.2      14.8    419.6    1.01       11     15.0    412.4    1.02       36     14.8    397.3    1.01      112       
100    14.9   419.3      16.3    421.1    1.09       12     14.2    407.8    0.95       35     14.1    390.3    0.95      108       
104    15.1   415.4      15.6    414.0    1.03       11     15.2    406.7    1.01       37     13.1    375.2    0.87      104       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.8   272.3      17.4    267.3    0.98       20     17.4    268.1    0.98       67     15.7    246.3    0.89      197       
SD(D)   1.1               0.9             0.04        6      1.1             0.02       18      0.5             0.04       45       
CV(E)   6.2               5.4             3.8      28.0      6.3             1.8      26.7      3.4             4.2      22.6       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   16.4   401.9      16.4    396.2    1.00       13     16.3    393.4    1.00       42     15.6    375.5    0.95      125       
SD(D)   0.5               0.5             0.03        1      0.5             0.03        4      0.7             0.04       12       
CV(E)   2.8               2.8             2.7       8.8      3.0             3.0       9.2      4.6             4.0       9.3       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   15.4   434.0      15.8    430.8    1.03       11     15.4    424.2    1.00       36     14.9    405.9    0.97      110       
SD(D)   1.0               0.9             0.03        1      0.8             0.03        1      0.9             0.05        4       
CV(E)   6.5               5.6             3.1       4.9      4.9             3.4       3.4      6.0             5.4       3.9       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                          
==================================================================================================================================  
            0PPM                      1000 PPM                           2500 PPM                           5000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4    13.2   148.0      13.2    148.1     1.00      89     11.5    141.7     0.87     202     10.1    133.3     0.77     381       
  8    11.4   173.0      11.3    175.4     0.99      65     11.1    167.6     0.97     165      9.6    154.0     0.84     310       
 12    10.8   183.7      11.1    183.5     1.03      61     10.4    176.9     0.96     147      9.1    160.2     0.84     286       
 16    10.3   192.9      10.5    191.1     1.02      55      9.8    183.6     0.95     134      8.2    166.4     0.80     245       
 20    10.2   197.8      10.0    197.1     0.98      51      9.5    190.9     0.93     124      8.3    170.7     0.81     242       
 24    10.1   204.4      10.4    203.4     1.03      51      9.3    196.6     0.92     119      8.2    177.7     0.81     229       
 28     9.8   210.2      10.2    208.4     1.04      49      9.8    202.4     1.00     121      8.4    185.1     0.86     226       
 32    10.5   217.0      10.6    214.8     1.01      49      9.9    207.7     0.94     119      9.2    192.7     0.88     237       
 36    10.3   224.1      10.7    220.2     1.04      49     10.1    213.7     0.98     118      9.1    196.5     0.88     232       
 40    10.6   230.7      10.6    228.1     1.00      47     10.1    220.7     0.95     115      9.0    203.7     0.85     220       
 44    11.1   238.1      11.0    235.2     0.99      47     10.7    225.3     0.96     119      9.2    205.9     0.83     223       
 48    10.7   241.7      11.0    240.1     1.03      46     10.5    229.6     0.98     114      9.3    211.3     0.87     221       
 52    10.8   245.9      11.9    247.2     1.10      48     10.9    234.7     1.01     116      9.1    211.1     0.84     215       
 56    11.9   256.6      11.3    256.9     0.95      44     10.8    239.6     0.91     112      9.6    216.9     0.81     221       
 60    11.9   268.4      12.2    266.0     1.03      46     11.6    249.3     0.97     117      9.8    219.9     0.82     224       
 64    11.5   274.5      11.6    273.4     1.01      42     11.2    253.8     0.97     111      9.5    222.8     0.83     214       
 72    12.3   290.8      11.8    287.9     0.96      41     10.8    264.1     0.88     102      8.6    228.3     0.70     189       
 76    11.8   296.9      11.6    291.2     0.98      40     11.6    269.2     0.98     108      9.5    229.6     0.81     207       
 80    12.1   297.2      12.0    293.4     0.99      41     11.8    272.7     0.98     109      9.8    229.8     0.81     214       
 84    11.2   299.6      11.3    295.3     1.01      38     11.3    274.9     1.01     102     10.0    232.4     0.89     214       
 88    11.1   304.2      11.8    299.1     1.06      39     11.4    278.5     1.03     102      9.3    234.2     0.84     199       
 92    11.0   312.3      10.8    304.4     0.98      35     10.4    282.9     0.95      92      9.0    232.1     0.82     194       
 96    12.3   313.9      12.7    305.5     1.03      41     12.0    285.0     0.98     105     10.0    232.7     0.81     215       
100    12.1   318.5      12.0    308.4     0.99      39     11.3    284.6     0.93      99      9.7    230.7     0.80     210       
104    12.0   320.6      12.0    308.5     1.00      39     12.0    283.1     1.00     106     10.0    227.5     0.83     219       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   11.8   168.2      11.9    169.0     1.01      71     11.0    162.1     0.94     171      9.6    149.1     0.82     325       
SD(D)   1.2               1.2              0.02      15      0.5              0.06      28      0.5              0.04      49       
CV(E)  10.6               9.7              1.9     21.7      5.0              6.0     16.5      5.2              5.5     15.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   10.4   220.3      10.7    218.6     1.02      49     10.1    210.5     0.96     120      8.8    192.1     0.84     229       
SD(D)   0.4               0.5              0.03       3      0.5              0.03       6      0.5              0.03      10       
CV(E)   3.9               4.9              3.3      5.5      5.1              3.0      4.8      5.4              3.5      4.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   11.8   296.1      11.8    290.8     1.00      41     11.4    269.8     0.97     105      9.6    228.1     0.81     210       
SD(D)   0.4               0.5              0.03       3      0.5              0.04       7      0.4              0.04      11       
CV(E)   3.8               4.1              3.1      6.7      4.4              4.4      6.2      4.4              5.4      5.2       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                   
                                CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
            0PPM                   300 PPM                  1000 PPM                 3000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              114.4  60                112.7  60                113.5  60                113.2  60                               
  1              114.4  60                112.7  60                113.5  60                113.2  60                               
  4  18.7  9780  212.8  60    18.5  9760  207.2  60    18.1  9738  209.0  60    15.8  9980  193.3  60                               
  8  18.0  9783  284.1  60    16.9  9745  279.9  60    18.0  9635  280.4  60    16.2  9610  256.9  60                               
 12  16.6 10165  320.1  60    16.8 10010  314.9  60    16.1 10035  314.8  60    15.2  9975  288.6  60                               
 16  16.9  9939  347.8  60    16.9  9917  343.6  60    17.0  9900  341.3  60    15.6  9740  318.1  60                               
 20  16.6  9991  366.6  60    16.5  9915  359.8  60    16.6  9975  359.6  60    15.1  9878  334.0  60                               
 24  16.6  9895  378.4  60    16.0  9895  371.0  60    15.8  9882  369.4  60    15.5  9740  347.0  60                               
 28  15.5  8388  385.8  50    15.9  8383  382.0  50    15.7  8374  376.6  50    14.1  8267  361.5  50                               
 32  16.5  8221  401.4  50    16.6  8100  395.1  50    16.3  8118  391.9  50    16.7  8072  376.7  50                               
 36  16.6  8114  414.6  50    16.7  8243  405.3  50    15.8  8131  402.6  50    16.3  8033  387.5  50                               
 40  16.8  8290  422.1  50    16.9  8135  418.7  50    16.8  8165  414.3  50    15.7  8077  399.5  49                               
 44  16.2  8258  428.6  50    17.0  8225  423.4  50    16.9  8187  420.7  50    16.3  8181  405.7  49                               
 48  16.3  7938  436.0  49    15.7  8095  428.2  50    15.9  8252  425.9  50    15.4  8056  410.5  49                               
 52  15.7  8150  437.4  49    16.2  8294  434.9  50    16.1  8291  431.6  50    15.3  8095  414.2  49                               
 56  16.6  7911  444.0  49    16.8  8100  437.1  50    16.2  8215  432.3  50    16.1  7947  416.7  49                               
 60  16.9  7917  445.6  49    17.3  8064  438.4  50    16.8  7891  435.2  49    16.4  7706  419.7  48                               
 64  16.3  7926  444.0  49    16.2  8065  439.8  50    16.2  7262  433.0  48    15.2  7728  413.4  48                               
 68              442.5  49                437.5  50                429.4  48                417.1  48                               
 72  15.8  8558  446.9  49    16.4  8734  439.2  50    15.6  8208  436.5  47    14.9  8191  422.1  47                               
 76  15.9  8217  443.1  49    15.7  7985  442.7  48    15.3  7819  434.8  47    14.6  7818  419.9  47                               
 80  15.7  6641  439.5  49    15.9  7683  432.5  47    15.6  7338  429.7  45    15.3  7773  409.8  47                               
 84  15.0  7980  435.9  48    15.1  7644  431.1  46    15.2  7256  425.2  44    15.1  7309  406.5  45                               
 88  14.3  7679  431.4  47    15.3  7171  428.8  44    15.2  7151  421.5  44    14.8  6642  400.1  42                               
 92  13.4  7499  421.5  46    14.1  7599  425.1  44    14.2  7014  415.8  44    14.1  7058  400.0  41                               
 96  14.7  7222  421.2  44    14.8  6944  419.6  43    15.0  6792  412.4  42    14.8  6662  397.3  41                               
100  14.9  6553  419.3  39    16.3  6702  421.1  40    14.2  6401  407.8  39    14.1  6078  390.3  35                               
104  15.1  5965  415.4  36    15.6  6568  414.0  40    15.2  5870  406.7  36    13.1  5690  375.2  35                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          232.8                    228.7                    229.5                    213.0                                   
14 TO 52         401.9                    396.2                    393.4                    375.5                                   
 > 52            434.6                    431.3                    424.6                    406.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                 
                                CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
            0PPM                   1000 PPM                 2500 PPM                 5000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               98.5  60                 99.2  60                 98.2  60                 97.7  60                               
  1               98.5  60                 99.2  60                 98.2  60                 97.7  60                               
  4  13.2  9838  148.0  60    13.2  9768  148.1  60    11.5  9726  141.7  60    10.1  9970  133.3  60                               
  8  11.4  9582  173.0  60    11.3  9653  175.4  60    11.1  9624  167.6  60     9.6  9564  154.0  60                               
 12  10.8 10128  183.7  60    11.1 10019  183.5  60    10.4  9990  176.9  60     9.1 10032  160.2  60                               
 16  10.3  9904  192.9  60    10.5  9884  191.1  60     9.8  9900  183.6  60     8.2  9858  166.4  60                               
 20  10.2 10026  197.8  60    10.0  9989  197.1  60     9.5  9924  190.9  60     8.3  9820  170.7  60                               
 24  10.1  9888  204.4  60    10.4  9882  203.4  60     9.3  9864  196.6  60     8.2  9860  177.7  60                               
 28   9.8  8390  210.2  50    10.2  8360  208.4  50     9.8  8310  202.4  50     8.4  8260  185.1  50                               
 32  10.5  8220  217.0  50    10.6  8135  214.8  50     9.9  8106  207.7  50     9.2  8065  192.7  50                               
 36  10.3  8110  224.1  50    10.7  8154  220.2  50    10.1  7932  213.7  49     9.1  8076  196.5  50                               
 40  10.6  8263  230.7  50    10.6  8230  228.1  50    10.1  8114  220.7  49     9.0  8260  203.7  50                               
 44  11.1  8292  238.1  50    11.0  8175  235.2  50    10.7  8052  225.3  49     9.2  8256  205.9  50                               
 48  10.7  7940  241.7  49    11.0  8250  240.1  50    10.5  7997  229.6  49     9.3  8119  211.3  50                               
 52  10.8  8145  245.9  49    11.9  8265  247.2  50    10.9  7909  234.7  48     9.1  8247  211.1  50                               
 56  11.9  7897  256.6  49    11.3  8237  256.9  50    10.8  7009  239.6  48     9.6  8117  216.9  50                               
 60  11.9  7906  268.4  49    12.2  8055  266.0  50    11.6  7735  249.3  48     9.8  8021  219.9  50                               
 64  11.5  7934  274.5  49    11.6  7901  273.4  49    11.2  7737  253.8  48     9.5  7878  222.8  49                               
 68              281.6  49                281.1  49                259.5  48                226.0  49                               
 72  12.3  8565  290.8  49    11.8  8215  287.9  47    10.8  8228  264.1  47     8.6  8565  228.3  49                               
 76  11.8  8144  296.9  49    11.6  7812  291.2  47    11.6  7700  269.2  46     9.5  8144  229.6  49                               
 80  12.1  5647  297.2  49    12.0  7344  293.4  45    11.8  6963  272.7  42     9.8  8110  229.8  49                               
 84  11.2  8049  299.6  48    11.3  7410  295.3  45    11.3  6728  274.9  41    10.0  7944  232.4  49                               
 88  11.1  7329  304.2  45    11.8  7149  299.1  44    11.4  6330  278.5  39     9.3  7938  234.2  49                               
 92  11.0  7624  312.3  44    10.8  7348  304.4  42    10.4  6433  282.9  37     9.0  8310  232.1  48                               
 96  12.3  6935  313.9  42    12.7  6863  305.5  42    12.0  5569  285.0  33    10.0  7755  232.7  47                               
100  12.1  6842  318.5  41    12.0  6594  308.4  40    11.3  5259  284.6  32     9.7  7437  230.7  45                               
104  12.0  6592  320.6  40    12.0  6364  308.5  39    12.0  4566  283.1  28    10.0  6917  227.5  42                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          150.8                    151.6                    146.1                    136.3                                   
14 TO 52         220.3                    218.6                    210.5                    192.1                                   
 > 52            295.0                    290.1                    269.0                    227.9                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.