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TDMS Study 92012-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                            2-METHYLIMIDAZOLE                                            DATE: 02/24/03  
EXPERIMENT: 92012 TEST: 05                                                                                        TIME: 13:43:01    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C92012B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      2-METHYLIMIDAZOLE                                           DATE: 02/24/03    
EXPERIMENT: 92012 TEST: 05                                                                                        TIME: 13:54:02    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  92012B      
CONT: N01-ES-85420                                                                                                CAS: 693-98-1     
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
                              TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                        
==========================================================================================================                          
WEEK     0PPM                   300 PPM                  1000 PPM                 3000 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B       114.4       60       112.7     98.5    60     113.5     99.2    60     113.2     99.0    60                               
  1       114.4       60       112.7     98.5    60     113.5     99.2    60     113.2     99.0    60                               
  4       212.8       60       207.2     97.4    60     209.0     98.2    60     193.3     90.8    60                               
  8       284.1       60       279.9     98.5    60     280.4     98.7    60     256.9     90.4    60                               
 12       320.1       60       314.9     98.4    60     314.8     98.3    60     288.6     90.2    60                               
 16       347.8       60       343.6     98.8    60     341.3     98.1    60     318.1     91.5    60                               
 20       366.6       60       359.8     98.1    60     359.6     98.1    60     334.0     91.1    60                               
 24       378.4       60       371.0     98.0    60     369.4     97.6    60     347.0     91.7    60                               
 28       385.8       50 (I)   382.0     99.0    50 (I) 376.6     97.6    50 (I) 361.5     93.7    50 (I)                           
 32       401.4       50       395.1     98.4    50     391.9     97.6    50     376.7     93.8    50                               
 36       414.6       50       405.3     97.8    50     402.6     97.1    50     387.5     93.5    50                               
 40       422.1       50       418.7     99.2    50     414.3     98.2    50     399.5     94.6    49                               
 44       428.6       50       423.4     98.8    50     420.7     98.2    50     405.7     94.7    49                               
 48       436.0       49       428.2     98.2    50     425.9     97.7    50     410.5     94.2    49                               
 52       437.4       49       434.9     99.4    50     431.6     98.7    50     414.2     94.7    49                               
 56       444.0       49       437.1     98.4    50     432.3     97.4    50     416.7     93.9    49                               
 60       445.6       49       438.4     98.4    50     435.2     97.7    49     419.7     94.2    48                               
 64       444.0       49       439.8     99.1    50     433.0     97.5    48     413.4     93.1    48                               
 68       442.5       49       437.5     98.9    50     429.4     97.0    48     417.1     94.3    48                               
 72       446.9       49       439.2     98.3    50     436.5     97.7    47     422.1     94.5    47                               
 76       443.1       49       442.7     99.9    48     434.8     98.1    47     419.9     94.8    47                               
 80       439.5       49       432.5     98.4    47     429.7     97.8    45     409.8     93.2    47                               
 84       435.9       48       431.1     98.9    46     425.2     97.5    44     406.5     93.3    45                               
 88       431.4       47       428.8     99.4    44     421.5     97.7    44     400.1     92.7    42                               
 92       421.5       46       425.1    100.9    44     415.8     98.6    44     400.0     94.9    41                               
 96       421.2       44       419.6     99.6    43     412.4     97.9    42     397.3     94.3    41                               
100       419.3       39       421.1    100.4    40     407.8     97.3    39     390.3     93.1    35*                              
104       415.4       36       414.0     99.7    40     406.7     97.9    36     375.2     90.3    35                               
TERM. SAC.            35                         40                       36                       35                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                              TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                        
==========================================================================================================                          
WEEK     0PPM                   1000 PPM                 2500 PPM                 5000 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        98.5       60        99.2    100.7    60      98.2     99.7    60      97.7     99.2    60                               
  1        98.5       60        99.2    100.7    60      98.2     99.7    60      97.7     99.2    60                               
  4       148.0       60       148.1    100.1    60     141.7     95.7    60     133.3     90.1    60                               
  8       173.0       60       175.4    101.4    60     167.6     96.9    60     154.0     89.0    60                               
 12       183.7       60       183.5     99.9    60     176.9     96.3    60     160.2     87.2    60                               
 16       192.9       60       191.1     99.1    60     183.6     95.2    60     166.4     86.3    60                               
 20       197.8       60       197.1     99.6    60     190.9     96.5    60     170.7     86.3    60                               
 24       204.4       60       203.4     99.5    60     196.6     96.2    60     177.7     86.9    60                               
 28       210.2       50 (I)   208.4     99.1    50 (I) 202.4     96.3    50 (I) 185.1     88.1    50 (I)                           
 32       217.0       50       214.8     99.0    50     207.7     95.7    50     192.7     88.8    50                               
 36       224.1       50       220.2     98.3    50     213.7     95.4    49     196.5     87.7    50                               
 40       230.7       50       228.1     98.9    50     220.7     95.7    49     203.7     88.3    50                               
 44       238.1       50       235.2     98.8    50     225.3     94.6    49     205.9     86.5    50                               
 48       241.7       49       240.1     99.3    50     229.6     95.0    49     211.3     87.4    50                               
 52       245.9       49       247.2    100.5    50     234.7     95.4    48     211.1     85.8    50                               
 56       256.6       49       256.9    100.1    50     239.6     93.4    48     216.9     84.5    50                               
 60       268.4       49       266.0     99.1    50     249.3     92.9    48     219.9     81.9    50                               
 64       274.5       49       273.4     99.6    49     253.8     92.5    48     222.8     81.2    49                               
 68       281.6       49       281.1     99.8    49     259.5     92.2    48     226.0     80.3    49                               
 72       290.8       49       287.9     99.0    47     264.1     90.8    47     228.3     78.5    49                               
 76       296.9       49       291.2     98.1    47     269.2     90.7    46     229.6     77.3    49                               
 80       297.2       49       293.4     98.7    45     272.7     91.8    42     229.8     77.3    49                               
 84       299.6       48       295.3     98.6    45     274.9     91.8    41     232.4     77.6    49                               
 88       304.2       45       299.1     98.3    44     278.5     91.6    39     234.2     77.0    49                               
 92       312.3       44       304.4     97.5    42     282.9     90.6    37     232.1     74.3    48                               
 96       313.9       42       305.5     97.3    42     285.0     90.8    33     232.7     74.1    47                               
100       318.5       41       308.4     96.8    40     284.6     89.4    32     230.7     72.4    45                               
104       320.6       40       308.5     96.2    39     283.1     88.3    28     227.5     71.0    42                               
TERM. SAC.            40                         39                       28                       42                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.