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TDMS Study 92012-05 Pathology Tables

NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03
Route: DOSED FEED                                                                                                 Time: 10:39:16

                                                      FINAL#1; REVISION#1




       Facility:  Southern Research Institute

       Chemical CAS #:  693-98-1

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                                                                        |             
      Basophilic Focus                     | X     X  X  X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X  X     X|             
      Hemorrhage                           |                         2                                                |             
      Hepatodiaphragmatic Nodule           |       X                       X                                          |             
      Infiltration Cellular, Mixed Cell    | 1     1  2  1  1  1  2     2  2  2  2  2  2  2     2  1  2     1  2     2|             
      Inflammation, Granulomatous          |          1  2                    2  2     2  1        1  1        2     2|             
      Mixed Cell Focus                     |                                  X     X        X           X            |             
      Bile Duct, Cyst                      |                                                             X            |             
      Bile Duct, Hyperplasia               |          1        2     3  1        1  1     2           1        1      |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                1              1                          1               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                    +     +        +                             +   |             
      Fat, Necrosis, Focal                 |                         2     2        2                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |       3                                                                  |             
      Acinus, Atrophy, Focal               |          2        1  1  2  1     4           1  1           1            |             
      Duct, Cyst, Focal                    |                                                                          |             
      Duct, Cyst, Focal, Multiple          |                   1     2                 2  2              2     2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Epithelium, Hyperplasia              |                                                       1                 1|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    2                     |             
      Epithelium, Hyperplasia, Focal       |                                  2                                       |             
      Glands, Ectasia, Focal               |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                  +                             +         |             
      Epithelium, Hyperplasia, Focal       |                                                                1         |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               1        2  1  1                 2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          1                                                               |             
      Angiectasis                          | 2                                                                        |             
      Cytoplasmic Alteration, Focal        | 2                                                        2              1|             
      Vacuolization Cytoplasmic, Focal     | 2                                         2                 2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2           3                                                            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |       1                          2                                       |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |       2                 3        2           2                           |             
      Pars Distalis, Degeneration, Cystic  |                                                 2                        |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Rathke's Cleft, Cyst                 |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  | 2     1  2  2  2  2  2  3  3  2  1  2  2  3  2  1  1  2  2  2  2  2  2   |             
      Follicle, Mineralization, Focal      | 1     1  1  1  1  1  1  1  1  1     1  1  1  1        1  1  1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                         +                       +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                2                                         3        3      |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                                              3                           |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Cyst                                 |                   1              2              3                        |             
      Periovarian Tissue, Cyst             |                                                             3            |             
      Periovarian Tissue, Cyst, Multiple   |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       3     2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                               2     2     1  1                    2  2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                         +                                                |             
      Epithelium, Cyst                     |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Myeloid Cell, Hyperplasia            |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +        +     +     +  +  +     +           +  +     +  +  +     +  +   |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Ectasia                 |                2                                                  3      |             
      Mediastinal, Hemorrhage              |                                                 2                        |             
      Mediastinal, Hyperplasia, Histiocytic|          3           3     3                 3                    3      |             
      Mediastinal, Pigmentation            |                                                 2                        |             
      Pancreatic, Ectasia                  |                                                                   3      |             
      Pancreatic, Hemorrhage               |                                  2              2                 3      |             
      Pancreatic, Hyperplasia, Histiocytic |          3                                   3        3  3        3      |             
      Pancreatic, Hyperplasia, Plasma Cell |          3                                                               |             
      Pancreatic, Pigmentation             | 3                                3              2     3                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  M  M  M  M  M|             
      Ectasia                              |                                           3                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                   3      |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Histiocytic             |                                                                   3      |             
      Pigmentation                         |                                        3        2                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                              2  2     2                  |             
      Inflammation, Granulomatous          |                                           2                       4      |             
      Pigmentation, Focal                  |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2     2     2  3  2     2  2        4  3  4  2           3  3  3     2   |             
      Ectasia                              |                                                    3                    4|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                    4                 3  4|             
      Hemorrhage, Focal                    |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |                                                                   +      |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                1                                                         |             
      Hemorrhage, Focal                    | 2                                                                        |             
      Hemorrhage                           |    1                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5|             
                                           | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Hyperplasia, Histiocytic             |                                  2              1  1  1                 2|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Granulomatous   |                   1                                                      |             
      Pigmentation, Focal                  | 2                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2           2                 1        2                                 |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                     3     3                              |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cataract                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Focal           |                                                                   2      |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Focal                   |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |          +                                               +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |          1     1  1        1  1     1  1  1  1     1  1  1  1  1  1     1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 2                       2           2  2                          3      |             
      Renal Tubule, Pigmentation           | 2                                1              1     1                 2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |             2                                                            |      2  2.0|
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X        X  X|     42     |
      Hemorrhage                           |                                                                      2   |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                     X                 X  X     X         |      6     |
      Infiltration Cellular, Mixed Cell    |    2  2  2  2  2  2  2  2  2  2  1  1  2  2  1  2  1  1  2  2        1  2|     42  1.7|
      Inflammation, Granulomatous          |          3  1  2     2  1                 2  1                       1   |     18  1.6|
      Mixed Cell Focus                     |    X        X     X     X  X  X              X     X     X        X  X   |     15     |
      Bile Duct, Cyst                      |                      X                                                   |      2     |
      Bile Duct, Hyperplasia               | 1        2        1        1              1  1  1  1  1        2        1|     20  1.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                   1        2           2              1           3  1   |      9  1.4|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                4         |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                               +                          +        +      |   8        |
      Fat, Necrosis, Focal                 |                               2                          2               |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |                1                             2     2        2            |     13  1.6|
      Duct, Cyst, Focal                    |                                                    2                     |      1  2.0|
      Duct, Cyst, Focal, Multiple          |             1     2                             2                        |      9  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |          2                                                               |      1  2.0|
      Epithelium, Hyperplasia              |          2                                                               |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
      Glands, Ectasia, Focal               |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                +         |   3        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                +         |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                      1   |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Angiectasis                          |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      3  1.7|
      Vacuolization Cytoplasmic, Focal     |    2  1        2                                1           2            |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  4           3        2                  |      5  2.8|
      Pars Distalis, Cyst                  |          3                                                               |      1  3.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                      1                                2                  |      4  1.5|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |    2                 2                                   2     3     2   |      9  2.2|
      Pars Distalis, Degeneration, Cystic  |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage, Focal     |             1                                                            |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    | 2                                                                        |      1  2.0|
      Rathke's Cleft, Cyst                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  2  3  3  3  3  3  3  2  3  1  2  3  3  2  3  2  2  2  2  2  2  2  2  2|     48  2.2|
      Follicle, Mineralization, Focal      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  1  1  1  1  1|     42  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Degeneration, Cystic                 |             2                                               3  2         |      6  2.5|
      Hyperplasia, Cystic                  |                            2                                             |      1  2.0|
      Inflammation, Chronic                |                                                             3            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                              2                 2         |      5  2.0|
      Periovarian Tissue, Cyst             |                      3                       4              3            |      4  3.3|
      Periovarian Tissue, Cyst, Multiple   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3                                                                  |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |    2     2                             1        2                        |     10  1.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                +         |   2        |
      Epithelium, Cyst                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                          3               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +  +           +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +   |  32        |
      Mediastinal, Angiectasis             |                                           3                              |      1  3.0|
      Mediastinal, Ectasia                 |                      3              3  3                                 |      5  2.8|
      Mediastinal, Hemorrhage              |                                           2                              |      2  2.0|
      Mediastinal, Hyperplasia, Histiocytic|                                  3  3  2                                 |      8  2.9|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Pancreatic, Ectasia                  |                                                 1                        |      2  2.0|
      Pancreatic, Hemorrhage               |          3                    3                                          |      5  2.6|
      Pancreatic, Hyperplasia, Histiocytic |       3              3  2  2  3              2  3  3  3     3        2   |     16  2.8|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M|   5        |
      Ectasia                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                          3               |      2  3.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                               3  2  2                                    |      6  2.2|
      Inflammation, Granulomatous          |          4                                                               |      3  3.3|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 1     2  2     3  2     4  2  2  2  2  2     2     2  3     2     2  2  2|     33  2.4|
      Ectasia                              |                                                                          |      2  3.5|
      Hyperplasia, Cystic                  |                                           3                              |      1  3.0|
      Hyperplasia                          |                                     2                          3         |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |             2  3  2     3           1  3  4                              |     10  2.9|
      Hemorrhage, Focal                    |                                                                   2      |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                +         |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                      +         |   3        |
      Hemorrhage, Focal                    |                                                                2         |      1  2.0|
      Necrosis, Focal                      |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                         +                                                |   2        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                              2                           |      2  1.5|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                                           1                              |      6  1.3|
      Inflammation, Chronic, Focal         |                                     1                                    |      1  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 1                       1                                         2      |      7  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Nasolacrimal Duct, Inflammation      | 3                    2                                                   |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0PPM                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                              3                           |      1  3.0|
      Cataract                             |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic, Focal           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                              2                           |      1  2.0|
      Hyperplasia, Focal                   |                                           1                              |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  1  1  1     1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  2  1  1   |     38  1.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |       2  2  2  2  2                                            3         |     11  2.2|
      Renal Tubule, Pigmentation           |          2                                1                    3         |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                             2            |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X|             
      Degeneration, Cystic, Focal          |                2                                                         |             
      Fatty Change                         |                                           3                              |             
      Hepatodiaphragmatic Nodule           |                                                       X        X         |             
      Infiltration Cellular, Mixed Cell    |    2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  1  2  2  2  2|             
      Inflammation, Granulomatous          | 4  2  2  2     2     2  2        2     2     2  2        2              2|             
      Mixed Cell Focus                     |       X        X                    X  X        X                        |             
      Necrosis, Focal                      |                                        2                                 |             
      Bile Duct, Hyperplasia               | 1     2  1  1  2     1        1  1     1           1  2  2     2     1   |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                2     1  1                                      1     1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +                    +        +           +  +  +         |             
      Fibrosis                             |                                                             1            |             
      Inflammation, Chronic                |                                              2                           |             
      Fat, Necrosis, Focal                 |                3                    2        3           3  2  3         |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Mixed Cell                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |    1     1                    1     1              1  1     1        1   |             
      Duct, Cyst, Focal, Multiple          |       2                          2                    1        2     1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic                |                                        3                                 |             
      Ulcer                                |                                        3  2                              |             
      Epithelium, Hyperplasia              |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2        1           2              2                          2   |             
      Infiltration Cellular, Mixed Cell    |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                       1     1            |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           4     2     2                  |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Cyst                  | 2           2                                                            |             
      Pars Distalis, Cyst, Multiple        |       2        3                                                         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                     2                                    |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |          2  3  2  2                 3           2  2           2         |             
      Pars Distalis, Hemorrhage, Focal     |                                     3                                    |             
      Pars Distalis, Hyperplasia, Focal    |                                                                      2   |             
      Pars Intermedia, Pars Nervosa,       |                                                                          |             
          Atypia Cellular, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      C-Cell, Hyperplasia                  | 3  2  2  2  3  3  2  3  2  2  2  3  3  2     2  2  2  3  2  2  2  2  2  1|             
      Follicle, Cyst                       | 2                                                                        |             
      Follicle, Mineralization, Focal      | 3  2  1  1  1  2  1  1  1  1  2  2  3  1  1  2  3  3  3  1  1  1  2  2  2|             
      Follicular Cell, Hyperplasia         | 1  2  2  1        1  1  2  1  2  1  2        1  1  2  2  2  2  1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Fibrosis, Focal                      |                                                                2         |             
      Hyperplasia, Cystic                  |                      2                          3                        |             
      Inflammation, Chronic                |                                  2              3        2           3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |          4           2                                      3            |             
      Periovarian Tissue, Cyst             |    3        4                                                            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |    1  3     2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      | 2                                                                        |             
      Myeloid Cell, Hyperplasia            |                3                                                         |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                                 3                 2      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +        +  +        +  +     +  +     +  +  +  +|             
      Mediastinal, Ectasia                 |                                  2                                   3   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|       3        3        3           3           3        3           2   |             
      Mediastinal, Hyperplasia, Lymphoid   |                         3                                                |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Atrophy                  |                                                                          |             
      Pancreatic, Ectasia                  |                3                                                         |             
      Pancreatic, Hemorrhage               |    3           3                                                         |             
      Pancreatic, Hyperplasia, Histiocytic | 3     3  3     3  3  1  3        3           3  3     2        3  3  3  3|             
      Pancreatic, Pigmentation             |                                                                         2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                         3                                                |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                         1                                                |             
      Angiectasis, Focal                   |                                                                          |             
      Congestion                           |                         3                                                |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                3                 2  2     3     2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Inflammation, Granulomatous          | 3                                                                        |             
      Pigmentation, Focal                  |                                                                         3|             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 4  2  2  2  4  4  2  3     2  2     2  3  2  3  3  1     4  2  2     2   |             
      Ectasia                              |                                                                         3|             
      Fibrosis                             |                                                                   3      |             
      Hyperplasia                          |             3                 2                             3            |             
      Inflammation, Focal                  |                         3                                                |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                      3                 4     3              3           3|             
      Hemorrhage, Focal                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |       +                                      +                           |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                          2      |             
      Hyperplasia, Histiocytic             |                         1                                               2|             
      Infiltration Cellular, Mixed Cell    | 2                                                                 2      |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           1           2                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                2         |             
      Inflammation, Suppurative            |                                                                2         |             
      Nasolacrimal Duct, Inflammation      |          2                                                               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cataract                             | 3                                   3                                    |             
      Retina, Degeneration                 | 3                                   3                                    |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                   2  1   |             
      Epithelium, Hyperplasia, Focal       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  2        1  1  1  1  1  1  1  1  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 2              4     1           1                                      3|             
      Renal Tubule, Pigmentation           |                                                                         2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     | X     X  X  X  X     X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|     44     |
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Fatty Change                         |    3                                                                     |      2  3.0|
      Hepatodiaphragmatic Nodule           |    X           X              X  X     X     X           X        X     X|     11     |
      Infiltration Cellular, Mixed Cell    | 2     1     2  2     2  2  2  2  2  3     2  2  2  2  2  2  2  2  2  2  1|     44  2.0|
      Inflammation, Granulomatous          | 2     2  2     1     1        2  2  3                          1     2   |     23  2.0|
      Mixed Cell Focus                     |       X        X     X     X  X           X        X  X  X               |     14     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    2  2  1  2        1        2     3     2  2  1  1  1        1     1  1|     29  1.4|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                1           2  2                          1        2      |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                          +        +                             +   |  10        |
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                               3                                          |      7  2.7|
      Fat, Necrosis                        |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Mixed Cell                       |                2                                                         |      1  2.0|
      Acinus, Atrophy, Diffuse             |    4                                                                     |      1  4.0|
      Acinus, Atrophy, Focal               |                2     1     2  1     2                                   1|     14  1.2|
      Duct, Cyst, Focal, Multiple          |    3  2        2                    3     2  2           1               |     12  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                   +                    +                             +   |   3        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2                                2                 2                     |      8  1.9|
      Infiltration Cellular, Mixed Cell    |                      2                                      1        2   |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  1.0|
      Angiectasis                          |                                                                      3   |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          3                                                     1  2      |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |             3        2              3     3  2        2                  |      9  2.6|
      Cyst                                 |                         3                                                |      1  3.0|
      Hemorrhage                           |             3                                                            |      1  3.0|
      Pars Distalis, Cyst                  |          3                                                               |      3  2.3|
      Pars Distalis, Cyst, Multiple        |                                                                          |      2  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1                 1              2                        |      4  1.5|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                  2           1  2  2     3  1            |     14  2.1|
      Pars Distalis, Hemorrhage, Focal     | 2                                                        3               |      3  2.7|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
      Pars Intermedia, Pars Nervosa,       |                                                                          |            |
          Atypia Cellular, Focal           |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Vacuolization Cytoplasmic, Focal     |                                     1                                    |      1  1.0|
      C-Cell, Hyperplasia                  | 2  2  3  2     2     1  2  3  3  3  2     1  2  2  1  3  3  1  3  2  2  2|     46  2.2|
      Follicle, Cyst                       |                            X                                             |      2  2.0|
      Follicle, Mineralization, Focal      | 1  2  2  3     2     1  1  2  2  2  1     1  2  2  2  1  2  1  1  2  2  2|     47  1.7|
      Follicular Cell, Hyperplasia         | 1     2  1  3  1     1        1  1  1     1  2  2  2  1  1  2  1  2  3  1|     41  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                           3  3  4     2                  |      4  3.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  |                            3        3                                    |      4  2.8|
      Inflammation, Chronic                |                1                                                         |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                             2            |      1  2.0|
      Atrophy                              |    3                                                                     |      1  3.0|
      Cyst                                 |       3                                                     2            |      5  2.8|
      Periovarian Tissue, Cyst             |    3                                                     3     3         |      5  3.2|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     | 2     2  2                       2  2     2     1  2  1     1     2      |     14  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |    3                                               2                     |      3  2.7|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +        +     +     +  +              +     +           +|  31        |
      Mediastinal, Ectasia                 |       3                                                                  |      3  2.7|
      Mediastinal, Hemorrhage              |             3                 3     3                                    |      3  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                         3|      8  2.9|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |       3                                                                  |      1  3.0|
      Pancreatic, Atrophy                  |    3                                                                     |      1  3.0|
      Pancreatic, Ectasia                  |       3                                                                  |      2  3.0|
      Pancreatic, Hemorrhage               |                         3                                                |      3  3.0|
      Pancreatic, Hyperplasia, Histiocytic | 1     3  3     3        3           3                 3     3           3|     24  2.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Pigmentation             |                         3                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  +  M  M  M  M  M|   4        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                                          |      1  1.0|
      Angiectasis, Focal                   |                                                                   2      |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                   2      |      1  2.0|
      Hematopoietic Cell Proliferation     | 2                       3                                            2   |      8  2.4|
      Inflammation, Granulomatous          |       3                                                                  |      2  3.0|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
      Pigmentation                         |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 2  4           2     2        3  2  3     2  3  3  2     2     2  3     3|     35  2.5|
      Ectasia                              |             2           2                                                |      3  2.3|
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia                          |                                     3  2                                 |      5  2.6|
      Inflammation, Focal                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression, Focal                   |             2                 3                                   3      |      8  3.0|
      Hemorrhage, Focal                    |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                        +                                 |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |             3                 2                                          |      4  2.3|
      Hyperplasia, Histiocytic             |             1           1                                   1        1   |      6  1.2|
      Infiltration Cellular, Mixed Cell    |          2                                                               |      3  2.0|
      Inflammation, Chronic, Focal         |                                  1                                   1   |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                 2                 2                                 |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                   2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                        3                                 |      1  3.0|
      Cataract                             |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      2  1.5|
      Epithelium, Hyperplasia, Focal       |       1                                                                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy, Focal                       | 2                             2                                          |      2  2.0|
      Nephropathy                          | 1     1  1     1     1        1  1  1     1  1  1  1  1  1     1  1  1   |     40  1.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |    2  1                                                                  |      7  2.0|
      Renal Tubule, Pigmentation           |                         1                                   1        2   |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                      4                                            3      |             
      Basophilic Focus                     | X  X     X  X        X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |             
      Congestion, Focal                    |                                                                          |             
      Congestion                           |                            2                                             |             
      Eosinophilic Focus                   |                                                                   X      |             
      Fatty Change                         |                                                                         2|             
      Hepatodiaphragmatic Nodule           |    X              X  X  X  X           X                             X   |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 2  2     2           2  2  2     2  2     2  2  2  2  2     2  2  2  2   |             
      Inflammation, Granulomatous          | 2     3              2        1  1  1        2  1     1  1     2     1  1|             
      Mixed Cell Focus                     |    X                                   X  X  X  X  X  X     X            |             
      Bile Duct, Cholangiofibrosis, Focal  |                                                                          |             
      Bile Duct, Cyst, Multiple            |                      X                                                   |             
      Bile Duct, Hyperplasia               | 1     2              2        3  1              1  1                 1   |             
      Hepatocyte, Necrosis, Focal          |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                      1                          1        2  1            |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        |             2                                                            |             
      Hepatocyte, Centrilobular, Necrosis  |                                                          3               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                3                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +           +     +           +                                    |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Fat, Necrosis, Focal                 |       3                             3                                    |             
      Fat, Necrosis                        |                         3                                                |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 1                                1     2        1     2                  |             
      Duct, Cyst, Focal, Multiple          |                                  2                                   2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                         3|             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |                                                                         2|             
      Epithelium, Hyperplasia              |             3     1                                                     3|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                2                                                         |             
      Inflammation, Chronic                |                                                                         2|             
      Necrosis, Focal                      |                                                                          |             
      Glands, Degeneration, Cystic, Focal  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1                 2  1                                    |             
      Infiltration Cellular, Mixed Cell    |                      2                          2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Accessory Adrenal Cortical Nodule    |          1                             1                                 |             
      Angiectasis                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                         1                                                |             
      Vacuolization Cytoplasmic, Focal     |    1                 3                                         3         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             4  2     2                                                   |             
      Metaplasia, Focal, Lipocyte          |                                                                          |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                      2                                                   |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                      2              3  2           3                     |             
      Pars Distalis, Hemorrhage, Focal     |                                                                         4|             
      Pars Distalis, Hyperplasia, Focal    |                                     3                                    |             
      Pars Distalis, Pigmentation, Focal   |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  3     2  2  1     2  2     1  2  3  2  2  2  2  2  2     1     3  2  2|             
      Follicle, Cyst                       | X                                                                        |             
      Follicle, Mineralization, Focal      | 3  2        1  2     3  1     1  1  3  2  3  3  3  3  3     1  2  3  3  2|             
      Follicular Cell, Hyperplasia         | 2  3           2     2           1  2  2  1  3  2  1  2     1  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |          +              +                                                |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Thoracic, Infiltration Cellular,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
           Focal, Mixed Cell               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                2         |             
      Hyperplasia, Cystic                  |                3                                                  3      |             
      Inflammation, Chronic                | 3                          1                                             |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Bilateral, Cyst, Multiple            |                                                                          |             
      Periovarian Tissue, Cyst             |                                                          3           2   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
      Hemorrhage                           |                                                                      2   |             
      Inflammation, Chronic                |                                                                      3   |             
      Cervix, Hyperplasia                  |                                                                      3   |             
      Endometrium, Hyperplasia, Cystic     |    1                 2                 1  2     1                 2      |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                      +  +|             
      Inflammation, Chronic                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            | 3                    2                                               3   |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +        +  +  +  +  +  +  +        +     +  +  +  +           +   |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                                                                      3   |             
      Mediastinal, Hemorrhage              |                                                          2               |             
      Mediastinal, Hyperplasia, Histiocytic|       3              3                                               3   |             
      Mediastinal, Hyperplasia, Lymphoid   |                            3                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hyperplasia             |    3                                                                     |             
      Mediastinal, Pigmentation            |       3                                                                  |             
      Pancreatic, Hemorrhage               |                         2                                                |             
      Pancreatic, Hyperplasia, Histiocytic |    3                 3  3        3        3     3  3  3              3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia, Histiocytic             |                                                                3         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                      2                                                   |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hemorrhage                           |                               2                                          |             
      Inflammation, Granulomatous          |                                     3                          1         |             
      Pigmentation, Focal                  |             3                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2  4                    3     2  2     2           4     2     3      |             
      Ectasia                              |             4                 3                          1              2|             
      Hyperplasia, Cystic                  |             3                                2                           |             
      Hyperplasia                          |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |    3  3     3              3                 3        2           3     4|             
      Hemorrhage, Focal                    |                   3                                                      |             
      Necrosis, Focal                      |                   3                                                      |             
      Pigmentation, Focal                  |                                                                          |             
      Cerebellum, Developmental            |                                                                          |             
          Malformation                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |             +                                                           +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |             +                                                           +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Emphysema                            |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |             1                                1                 1        1|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           2                              |             
      Interstitium, Edema                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                      2                                3                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Cataract                             |                                     2                                    |             
      Iris, Synechia                       |                                     3                                    |             
      Retina, Degeneration                 |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic, Focal         |                            1                                      2      |             
      Inflammation, Focal, Granulomatous   |                                                                1         |             
      Epithelium, Hyperplasia, Focal       |                                     2                             2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Congestion                           |       3                                                                  |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  1     1  1     1  1  1        1  1  1  1     1  1  1     1     1  1  1|             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                              1                           |             
      Renal Tubule, Pigmentation           |                                              1                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      2  3.5|
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X|     43     |
      Congestion, Focal                    |          2                                                               |      1  2.0|
      Congestion                           |                                                    3                     |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |          X                             X  X  X  X  X  X                  |     14     |
      Hyperplasia, Focal, Lymphoid         |                            3                                             |      1  3.0|
      Infiltration Cellular, Mixed Cell    | 2  2  2  1           2  2     2  2        2  2     2  2  2     2  2  1  2|     34  1.9|
      Inflammation, Granulomatous          |                   1  2     2  2                    1  2  1  2  2         |     22  1.5|
      Mixed Cell Focus                     | X                 X                                            X         |     11     |
      Bile Duct, Cholangiofibrosis, Focal  |                                                          2               |      1  2.0|
      Bile Duct, Cyst, Multiple            |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 1     1     2  2  2  1  1  1  2  2              2                    1   |     20  1.5|
      Hepatocyte, Necrosis, Focal          |                                     2                                    |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               | 1           1     1           1  1                       1              2|     11  1.2|
      Hepatocyte, Periportal,              |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                3                    2  4                                 |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +              +           +           +  +     +     +      |  12        |
      Infiltration Cellular, Mixed Cell    |                                                    2                     |      1  2.0|
      Fat, Necrosis, Focal                 |    2        3              3                       3                     |      6  2.8|
      Fat, Necrosis                        |                                                       2                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |    1     1           2     3     2     2           2           2         |     13  1.7|
      Duct, Cyst, Focal, Multiple          |                   2                                                  2   |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                        2                                 |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Focal                  |                                        2                                 |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                        3                                 |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                        2                                 |      1  2.0|
      Glands, Degeneration, Cystic, Focal  |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2           2     1                                   2                  |      7  1.6|
      Infiltration Cellular, Mixed Cell    |                                                    2                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          1                                1                 2            |      5  1.2|
      Angiectasis                          |                2                                                         |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                         1     3                 1  1                     |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             3                          3                 2  3            |      7  2.7|
      Metaplasia, Focal, Lipocyte          | 2                                                                        |      1  2.0|
      Pars Distalis, Cyst                  |    2                                                                     |      2  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  2.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |             2  2        3                 2                              |      8  2.4|
      Pars Distalis, Hemorrhage, Focal     |                         3           2  3                                 |      4  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Pigmentation, Focal   |                                     2                                    |      1  2.0|
      Pars Intermedia, Cyst                |          2                                                               |      1  2.0|
      Rathke's Cleft, Cyst                 | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +|  42        |
      C-Cell, Hyperplasia                  | 2  2  2     1  2  2  2  2     2  2  2  2  2  2  2        2     2  2  2  2|     40  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Mineralization, Focal      | 3  3  3  1  3  3  3  3  3     3  3  3  3  1  1  1        3     3  3  3  3|     41  2.4|
      Follicular Cell, Hyperplasia         | 2  2  2           2  2  2     1  1  2     2  1  1        1     1  1  2  2|     34  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                        +           +                     |   4        |
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Mixed Cell                      |                                                    3                     |      1  3.0|
      Thoracic, Infiltration Cellular,     |                                                                          |            |
           Focal, Mixed Cell               |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  |                                                                      3   |      3  3.0|
      Inflammation, Chronic                |                                                    2                 3   |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          3                                                               |      1  3.0|
      Cyst                                 |       2                                                                  |      1  2.0|
      Bilateral, Cyst, Multiple            |                                                                   4      |      1  4.0|
      Periovarian Tissue, Cyst             |                            3                             4               |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           | 2                                                                        |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Cervix, Hyperplasia                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2     1           2  2        1                          2     2     2  1|     15  1.6|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Vagina                                  |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                         3                                               2|      5  2.6|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +           +  +  +     +  +     +  +  +  +  +     +|  34        |
      Mediastinal, Congestion              |          3                                                               |      1  3.0|
      Mediastinal, Ectasia                 | 3                                                                        |      2  3.0|
      Mediastinal, Hemorrhage              |          3        3                          3        2  3     3  3     3|      9  2.8|
      Mediastinal, Hyperplasia, Histiocytic|             3                                                           3|      5  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |                                              3                           |      2  3.0|
      Mediastinal, Pigmentation            |             3                                                            |      2  3.0|
      Pancreatic, Hemorrhage               |                                     3                                    |      2  2.5|
      Pancreatic, Hyperplasia, Histiocytic | 3  3  3           3  3           3                             3        3|     17  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  +|   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                     3                                    |      2  3.0|
      Hyperplasia, Histiocytic             |          3                                                               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Accessory Spleen                     |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     |                   2  3              3     3                              |      5  2.6|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                     4                       2            |      4  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pigmentation, Focal                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                       3                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |    3  3     2        2     3  2                 2  3     4     3  2  3   |     22  2.6|
      Ectasia                              |                2                                      2     2            |      7  2.3|
      Hyperplasia, Cystic                  |                                                                          |      2  2.5|
      Hyperplasia                          |                                                       1        3        2|      4  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                            3                          3           3     2|     12  2.9|
      Hemorrhage, Focal                    |                                                             3            |      2  3.0|
      Necrosis, Focal                      |                                                             3            |      2  3.0|
      Pigmentation, Focal                  |                               2                                          |      1  2.0|
      Cerebellum, Developmental            |                                                                          |            |
          Malformation                     |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                             +                                 |   4        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Spinal Cord                             |          +                             +                                 |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             2                                         2                  |      2  2.0|
      Emphysema                            |                                                    3                     |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                            1                                             |      1  1.0|
      Hyperplasia, Histiocytic             |          1     1                       1                                 |      7  1.0|
      Infiltration Cellular, Mixed Cell    |                                                    3                     |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                      2   |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    1                                                                 2   |      3  1.7|
      Interstitium, Edema                  |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      | 2                             2                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                        3                                 |      1  3.0|
      Cataract                             |                                                       1                  |      2  1.5|
      Iris, Synechia                       |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |       2                                                                  |      1  2.0|
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
      Inflammation, Chronic, Focal         | 1                                                                        |      3  1.3|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    2500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  47        |
      Atrophy, Focal                       |                                                                         2|      1  2.0|
      Congestion                           |                            3                                             |      2  3.0|
      Infarct                              |                2                                                         |      1  2.0|
      Nephropathy                          | 1  1  2  1  1  2  1  1  1  1  1  1  1  1  1  1              1  1  1  1   |     38  1.1|
      Pelvis, Inflammation                 |                                                                         2|      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                3                    3                                    |      3  2.3|
      Renal Tubule, Pigmentation           |          2     3                    2           3                        |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X        X     X  X  X  X  X  X  X     X     X  X  X  X  X  X|             
      Cholangiofibrosis                    |                                                       2                  |             
      Congestion                           |                                                             4            |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | X        X     X        X  X        X                             X      |             
      Hyperplasia, Focal, Lymphoid         |                                        2                                 |             
      Infarct                              |                                                             X            |             
      Infiltration Cellular, Mixed Cell    | 2  2        2  2  3  2  2  2  1     2  2  2  2           2  2  2  2  2  2|             
      Inflammation, Granulomatous          | 1  4  3  1  2  2  2  2  3  2  2  2  2  1  2  2  3  3        2  3  2  2  2|             
      Mixed Cell Focus                     |    X        X           X  X  X  X     X  X  X           X     X  X      |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Cyst, Multiple            |                                                 X                        |             
      Bile Duct, Hyperplasia               | 2     3        2  2  1  2              2  1  1  2  2  4  1  1  3  2  2  1|             
      Hepatocyte, Necrosis, Focal          |          2                                                               |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |             2           1              2     2                       2   |             
      Hepatocyte, Centrilobular, Necrosis  |                   3                                                      |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                       2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                 +  +                             +|             
      Hemorrhage, Focal                    |                                                                          |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Fat, Necrosis, Focal                 |                                           2                             2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |    2                                                                     |             
      Acinus, Atrophy, Focal               | 3        1                 1                       1           2  1      |             
      Duct, Cyst, Focal                    |                                                                          |             
      Duct, Cyst, Focal, Multiple          |          2           2                             2                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Mineralization, Focal          |                                                          3               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |             1                                                            |             
      Edema                                |                   3                                                      |             
      Ulcer                                |                   2                                                      |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |          +        +                       +                              |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                             1     2      |             
      Infiltration Cellular, Mixed Cell    |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    1                       1                                             |             
      Angiectasis                          |                                     2                                    |             
      Cytoplasmic Alteration, Focal        |                      1     1  1                 2        2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                  1           2        2           2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3  3      |             
      Pars Distalis, Angiectasis           |                                                                      2   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                              2              1            |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |       2        2                                                         |             
      Pars Distalis, Hemorrhage, Focal     |                                        2     2           3               |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Cyst                | 2                                   2  2                                 |             
      Pars Intermedia, Degeneration,       |                                                                          |             
          Cystic, Focal                    |       2                                                                  |             
      Pars Intermedia, Hemorrhage          |       2                                                                  |             
      Rathke's Cleft, Hemorrhage           |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     2                    2  2  2     2  1  2  2     1  1  1      |             
      Follicle, Mineralization, Focal      | 2  3  3  3  2  3  3  3  3  2  3  2  3  2  2  3  3  3  3  3  3  3  3  3  3|             
      Follicular Cell, Hyperplasia         | 3  3  2  2  2  3  2  3  3     3  3  3  2  2  2  2  2     2  2  3  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Pelvic, Hemorrhage, Focal            |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Cystic                  |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                                                    4                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |             1                 1                 2              2  1     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |    2              3                             2  2                     |             
      Myelofibrosis                        |                                                       3                  |             
      Necrosis                             |                   2                                                      |             
      Myeloid Cell, Hyperplasia            |             3                       3                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +  +  +  +     +|             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Mediastinal, Ectasia                 |             3        2                    3     4           2            |             
      Mediastinal, Hemorrhage              |             3                                   3     3                  |             
      Mediastinal, Hyperplasia, Histiocytic| 3  3     3     3        3  3                             3               |             
      Mediastinal, Hyperplasia, Lymphoid   |          3                                                               |             
      Pancreatic, Ectasia                  |             3              3     3              3  3           3  2      |             
      Pancreatic, Hemorrhage               |    3              3  3           3                    3  3               |             
      Pancreatic, Hyperplasia, Histiocytic | 3  4  3           4     4           3     3        3           3  2     3|             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Mixed Cell                      |          3                                                               |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                3        3           3                                    |             
      Hemorrhage                           |       3                             3                                    |             
      Hyperplasia, Histiocytic             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |    4        2  3  4  4  3  3  2  4  4     3  3  4  4     3  3  4        4|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                 3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2           3        2           2  2                       2  2     3   |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                4        3                                                |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Suppurative              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1                                                        2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Hemorrhage, Focal                    |                         2                                                |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |                               2                                          |             
      Infiltration Cellular, Focal, Mixed  |                                                                          |             
          Cell                             |                      2                                                   |             
      Infiltration Cellular, Mixed Cell    |                   2                       2                 2            |             
      Inflammation, Focal, Granulomatous   |                         1                                                |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       2                                                                  |             
      Alveolus, Inflammation, Focal,       |                                                                          |             
          Granulomatous                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                   3      |             
      Retina, Degeneration                 |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |    2           1                                                         |             
      Hyperplasia, Focal                   |                               1                                          |             
      Inflammation, Chronic, Focal         |                                                                3         |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Nephropathy                          | 1  1  1  1  1  1        1        1  1  1  2  1  1  1     1  1  1  1  2  1|             
      Glomerulus, Amyloid Deposition,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
          Droplet                          |                   2                 3                                    |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                         +                                      +         |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                2         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                4        2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Necrosis, Focal                      |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X     X  X  X     X  X  X        X  X  X  X  X  X  X  X  X  X  X  X  X|     39     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic, Focal          |                2  2                                                      |      2  2.0|
      Hemorrhage                           |       2                    2                                             |      2  2.0|
      Hepatodiaphragmatic Nodule           |                X     X              X        X        X              X   |     13     |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
      Infarct                              |                                                    X                     |      2     |
      Infiltration Cellular, Mixed Cell    |    2  2  2  1        2  2  2        1  2  2  2  2  2     2  2  2  2  2  2|     38  1.9|
      Inflammation, Granulomatous          | 2  2  2     2  2     4  2  2  2     2     2  2  2  2  3  2     2  2  1   |     42  2.1|
      Mixed Cell Focus                     |       X  X  X  X                    X     X  X  X  X     X  X     X  X  X|     26     |
      Necrosis, Focal                      |                            2                                             |      1  2.0|
      Bile Duct, Cyst, Multiple            |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 3     2  2  2     2  3  2  1  2  2  1  1  1  2  1  2  2     2  1  2  2  2|     40  1.9|
      Hepatocyte, Necrosis, Focal          |       2                                                                  |      2  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Cytoplasmic, Focal               |       2  1  2                                                  2         |      9  1.8|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +     +  +              +           +                           |   9        |
      Hemorrhage, Focal                    |                                              2                           |      1  2.0|
      Artery, Inflammation, Chronic, Focal |                3                                                         |      1  3.0|
      Fat, Necrosis, Focal                 |          2                                                               |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  2.0|
      Acinus, Atrophy, Focal               |    3              2     2  3                                   2         |     11  1.9|
      Duct, Cyst, Focal                    |                                                                         2|      1  2.0|
      Duct, Cyst, Focal, Multiple          |                                        2        1                        |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Mineralization, Focal          |                                           2                              |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                     2                                    |      2  1.5|
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Hyperplasia, Focal           |             2                                               2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                  +                                       |   4        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                2                                   1        2  2         |      6  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Infiltration Cellular, Mixed Cell    |                                                                   1      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                1                                            1           1|      5  1.0|
      Angiectasis                          |                         2                                                |      2  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      5  1.4|
      Vacuolization Cytoplasmic, Focal     |          2     1  2     1  1        1     1           3                  |     12  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   1                                1                     |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  3.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | 2                                                                        |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |       2                                                                  |      3  1.7|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           | 2              3                    2                                    |      5  2.2|
      Pars Distalis, Hemorrhage, Focal     |                                                    3     3           3   |      6  2.7|
      Pars Distalis, Hyperplasia, Focal    |    2                                                                     |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      3  2.0|
      Pars Intermedia, Degeneration,       |                                                                          |            |
          Cystic, Focal                    |                                                                          |      1  2.0|
      Pars Intermedia, Hemorrhage          |                                                                          |      1  2.0|
      Rathke's Cleft, Hemorrhage           |                   3                                                      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      C-Cell, Hyperplasia                  |    2  2  2     2  2  2  1  2        1           1           2     2     2|     25  1.7|
      Follicle, Mineralization, Focal      | 3  3  1  3  2  3  3  3  3  2  2     2  3  2  2  3  3     2  3  3  3  3  3|     48  2.7|
      Follicular Cell, Hyperplasia         | 2  2  1  2  3  3  2  1  2  1  1     2  2  1  2  2  1     2  2  2  3  3  2|     46  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                               +                                          |   2        |
      Pelvic, Hemorrhage, Focal            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                       3                  |      1  3.0|
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Periovarian Tissue, Cyst             | 3     3              3  2              3                                 |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2                                                                  |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |          3     1           2           1     2  2        1  1           2|     15  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                  3                                       |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      4  2.3|
      Myelofibrosis                        |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +     +   |  41        |
      Deep Cervical, Hemorrhage            |       3                                   3                              |      2  3.0|
      Mediastinal, Ectasia                 |                3                                3                        |      7  2.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Hemorrhage              |                      3  3                    3     3           2         |      8  2.9|
      Mediastinal, Hyperplasia, Histiocytic|    3                                   3     3              3        3   |     12  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |             3  2                                            3  2         |     11  2.7|
      Pancreatic, Hemorrhage               |                         3     3                 3                        |      9  3.0|
      Pancreatic, Hyperplasia, Histiocytic |       3              3     3           3           3  3              3   |     18  3.1|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Mixed Cell                      |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |       3                       3                                          |      5  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Histiocytic             |                                                       3                 3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                           2                 2     2     2|      4  2.0|
      Infarct                              |                3                                                         |      1  3.0|
      Inflammation, Granulomatous          |             4        3  4     2           2     3     4     3  3         |     27  3.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                2  2        3  2        2     2     2  3        2     2  4|     19  2.3|
      Hyperplasia                          |                                           2                    2        2|      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Focal                      |       3                                                  3               |      4  3.3|
      Ulcer                                |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                     2                                    |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |    3                                                                     |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Suppurative              |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                            4  3           3                          2   |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  1.5|
      Hemorrhage, Focal                    |                                                       3                  |      2  2.5|
      Hyperplasia, Focal, Histiocytic      | 3                                                                        |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Infiltration Cellular, Focal, Mixed  |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |       2                    2                                            2|      6  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 2        2                                                               |      3  2.0|
      Alveolus, Inflammation, Focal,       |                                                                          |            |
          Granulomatous                    |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation, Suppurative            |    3                                                                     |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                      2                                               1   |      4  1.5|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Focal       |                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  1  1  3  1  1  1  1        1  1  1  1  1  1     1  1     1  1  1|     40  1.1|
      Glomerulus, Amyloid Deposition,      |                                                                          |            |
          Diffuse                          |                3                                                         |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                   2     3                                                |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                    X     X              X  X     X           X     X   |             
      Cholangiofibrosis                    |                                                                          |             
      Degeneration, Cystic, Focal          |                                     2  2                 1               |             
      Eosinophilic Focus                   |                                  X                                       |             
      Hepatodiaphragmatic Nodule           | X  X                                                                     |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 2  2  2  2        2  2  3                    2     2        2  2        2|             
      Inflammation, Granulomatous          |    1                    1  2              1     1                    1   |             
      Mixed Cell Focus                     |                            X  X              X     X           X     X   |             
      Necrosis, Focal                      |                                                          2        3      |             
      Bile Duct, Hyperplasia               | 3  1  3  3  2  3     3  2  2  2  3  4  3  3  3  3  3  3  3  2  3  3  3  3|             
      Hepatocyte, Necrosis, Focal          |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               | 2     2                    2  2           2     2  2        2  1     2  2|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                3                                      3                  |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +        +  +                    +                    +        +      |             
      Fat, Necrosis, Focal                 |    3                                                              3      |             
      Fat, Necrosis                        |                                     2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |    2     3           1     2  2        2              4  3        2      |             
      Duct, Cyst, Focal, Multiple          |                                     3                 3                 2|             
      Duct, Cyst                           |                               1                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Focal                  |                2                                                         |             
      Ulcer                                |                                                       1                  |             
      Epithelium, Hyperplasia              |                                                          2               |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                   2      |             
      Erosion                              |             2  2                                      2                  |             
      Inflammation, Focal                  |             2                                                            |             
      Ulcer                                |                1                                         1               |             
      Glands, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Peridontal Tissue, Inflammation      |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +                                               +                     |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                   2        2                                             |             
      Thrombosis                           |                                                       3                  |             
      Endocardium, Myocardium, Fibrosis,   |                                                                          |             
           Focal                           |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                     2                                    |             
      Cytoplasmic Alteration, Focal        |                                     2                                    |             
      Hemorrhage                           |                                     2                                1   |             
      Vacuolization Cytoplasmic, Focal     | 2                          2                                         1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                1                                      1           1      |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
      Bilateral, Hyperplasia, Focal        |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                   1|             
      Pars Distalis, Angiectasis           |                                        3                                 |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                         1                                                |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2  1  2  2     2     2  2  1  2     2  2  1  1  1  1  1     1     1|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Mineralization, Focal      | 1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Follicular Cell, Atrophy, Focal      |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                               +                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                +  +                                                  +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Penis                                   | +                                                                        |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |             2  3                                                         |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Inflammation, Chronic                | 3           2                 3                             3     1      |             
      Epithelium, Degeneration, Focal,     |                                                                          |             
           Mucoid                          |       2                                                                  |             
      Epithelium, Hyperplasia, Focal       |                                        2  1                              |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3              3              3            |             
      Mineralization, Focal                |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Germinal Epithelium, Atrophy         |             3                                                            |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +        +        +  +  +  +     +        +  +  +  +  +  +|             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |          3                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Angiectasis              |                                     3                                    |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                     3                                    |             
      Pancreatic, Hyperplasia, Focal,      |                                                                          |             
          Histiocytic                      |                                           3                              |             
      Pancreatic, Hyperplasia, Histiocytic |       3  3              3                       3           2  3     3  2|             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                3                                                         |             
      Fibrosis, Focal                      |                3                       2                                 |             
      Hematopoietic Cell Proliferation     |                   3     3                                                |             
      Infarct                              |                                        X                                 |             
      Necrosis, Focal                      |                                        4                                 |             
      Capsule, Fibrosis, Focal             |                            2                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Atrophy                              |             3                                                            |             
      Cyst, Multiple                       |                                                                      4   |             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia, Lymphoid                |                         3                    3                           |             
      Epithelial Cell, Hyperplasia         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                              2                           |             
      Hyperplasia                          | 2                                                           2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Fibrosis, Focal                      |                                                 3                        |             
      Hemorrhage, Focal                    |                                  2                                       |             
      Inflammation, Chronic, Focal         |    2                                                                     |             
      Pinna, Necrosis, Focal               |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                        3                                 |             
      Hemorrhage, Focal                    |                                                          3               |             
      Necrosis, Focal                      |                                                          3               |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |             +                                                            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hemorrhage, Focal                    |                                                       2                  |             
      Hyperplasia, Focal, Histiocytic      |          2           2                                2                  |             
      Hyperplasia, Histiocytic             |             1                       2                    1               |             
      Infiltration Cellular, Mixed Cell    |                   3                                                      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         2                                                |             
      Inflammation, Suppurative            |                         2                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3|             
                                           | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Iris, Hyperplasia                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                         1|             
      Epithelium, Hyperplasia, Focal       |                                           2           1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                   3      |             
      Congestion                           |             2                                                            |             
      Inflammation                         |                   2                                                      |             
      Nephropathy                          | 1     1  1  3  1  1  1  1  2  1  1  1     1  1  1  1  3  2  1  1     1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                          3               |             
      Renal Tubule, Necrosis, Focal        |                   2                                                      |             
      Renal Tubule, Pigmentation           |                                     2                 3  3        3      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X        X  X     X  X  X  X     X  X  X  X        X  X           X     X|     23     |
      Cholangiofibrosis                    |                                                 4                        |      1  4.0|
      Degeneration, Cystic, Focal          |                                                                      2   |      4  1.8|
      Eosinophilic Focus                   |                                              X                       X   |      3     |
      Hepatodiaphragmatic Nodule           |                   X              X                                   X  X|      6     |
      Hyperplasia, Focal, Lymphoid         |                                                                2         |      1  2.0|
      Infiltration Cellular, Mixed Cell    | 1  2              1              2     2  2     2  2  2     2  2  2     2|     25  2.0|
      Inflammation, Granulomatous          |                      1              2  1        1              2  1      |     12  1.3|
      Mixed Cell Focus                     |             X     X  X  X        X        X  X              X            |     14     |
      Necrosis, Focal                      |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               | 3  3  4  1  3  2  2  3  3  2  3  2  3  3  3  4  3  3  2  2  3  2  2  3  3|     49  2.7|
      Hepatocyte, Necrosis, Focal          |                                                                      4   |      1  4.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    2     1  2     2     1           1  1  2        2  2           2     2|     23  1.8|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |       3                       3                          2               |      5  2.8|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +|  26        |
      Fat, Necrosis, Focal                 | 3           3     3  2        3                             3            |      8  2.9|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |       3        2     2  1     2        1     2  1  1  1  1  1  3         |     22  1.9|
      Duct, Cyst, Focal, Multiple          | 2                                         4     2                        |      6  2.7|
      Duct, Cyst                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                 1                        |      1  1.0|
      Edema                                |       3                                                                  |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Ulcer                                |       2                                                                  |      2  1.5|
      Epithelium, Hyperplasia              |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                                                          |      1  2.0|
      Erosion                              |                1                                                         |      4  1.8|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  1.0|
      Glands, Hyperplasia, Focal           |                                                                      1   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |             +     +  +  +        +  +  +  +     +  +  +     +     +     +|  16        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                          1               |      3  1.7|
      Thrombosis                           |                                                                          |      1  3.0|
      Endocardium, Myocardium, Fibrosis,   |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                      2                                                   |      2  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic, Focal     | 2                                                  1        1            |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                      2                          1     2              1   |      7  1.3|
      Hyperplasia                          |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Pars Distalis, Angiectasis           |                            2     2                                       |      3  2.3|
      Pars Distalis, Cyst                  | 2                                                                        |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                         2                                                |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                      1   |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |    2  1  2  2  1  2  2  1     1  3  2  2  2     2  2  2  2  2  2  2  2  2|     41  1.7|
      Follicle, Cyst                       |       X                                                                  |      1     |
      Follicle, Mineralization, Focal      | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.0|
      Follicular Cell, Atrophy, Focal      |                                                                      1   |      1  1.0|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |       +        +                             +                       +   |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 3                        |      1  3.0|
      Hyperplasia, Cystic                  | 3           3                                                            |      2  3.0|
      Hyperplasia, Focal                   |    2                                                                     |      1  2.0|
      Inflammation, Chronic                |                                           2     1                        |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |       3        1        1  2     1              1  1  1        2  2      |     15  1.8|
      Epithelium, Degeneration, Focal,     |                                                                          |            |
           Mucoid                          |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |    1                                      1                              |      4  1.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3                          4                                             |      5  3.2|
      Mineralization, Focal                |                         1                                                |      1  1.0|
      Bilateral, Atrophy                   |                                                                4     3   |      2  3.5|
      Germinal Epithelium, Atrophy         |                2                                                         |      2  2.5|
      Interstitial Cell, Hyperplasia, Focal|                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  39        |
      Mediastinal, Ectasia                 |                                  3                                       |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                       2           3      |      2  2.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                  3                                       |      1  3.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                                     3                                    |      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Focal,      |                                                                          |            |
          Histiocytic                      |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                      3     3     3                 3           3         |     13  2.8|
      Pancreatic, Pigmentation             | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Hyperplasia, Histiocytic             |                            3                                             |      1  3.0|
      Hyperplasia, Lymphoid                |                      3                                                   |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Fibrosis, Focal                      |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                       2           2      |      4  2.5|
      Infarct                              |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  4.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |       2                       2              2        2        3  2      |      7  2.1|
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Pinna, Necrosis, Focal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                 +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Compression, Focal                   |                                                       3        3  3      |      4  3.0|
      Hemorrhage, Focal                    |                2                                                         |      2  2.5|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                              3                           |      4  2.3|
      Hyperplasia, Histiocytic             |                                                                          |      3  1.3|
      Infiltration Cellular, Mixed Cell    |                            2                                             |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1                        |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                      2   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             | 3                                                                        |      1  3.0|
      Iris, Hyperplasia                    |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Focal       |                                                                      1   |      3  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2|            |
                                           | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0PPM                                   | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Nephropathy                          | 1  1     1  1     2  2  1     1  3  1  1  1  2  2  2  1     1  1  2  2  1|     43  1.3|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Focal        |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                               3                                          |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X        X  X  X  X        X  X     X        X  X              X|             
      Degeneration, Cystic, Focal          |                                                                      1   |             
      Hepatodiaphragmatic Nodule           | X                       X                       X                        |             
      Infiltration Cellular, Mixed Cell    |       2  2  2  2     2  2  2  2     2  2     2     1     2     2  2  2  2|             
      Inflammation, Granulomatous          |                   2  1                                         1  2      |             
      Mixed Cell Focus                     | X        X     X        X     X     X  X                                X|             
      Bile Duct, Hyperplasia               | 3  3  3  2  3  2  3  3  2  3  3  2  2  3  3  3  2  1  3  3  3  2  2  3  3|             
      Hepatocyte, Necrosis, Focal          |                                           1                              |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             | 2                                                                        |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |          2  1  2  1  2  2  2  1     2  2     2  2  2     2           2  2|             
      Hepatocyte, Centrilobular, Necrosis  |                                  2                                       |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                  3                                       |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Serosa, Fibrosis, Focal              |                                                    2                    3|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fat, Necrosis, Focal                 |    3                    3              2     1                           |             
      Fat, Necrosis                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             | 4                                                                        |             
      Acinus, Atrophy, Focal               |       2  1  3  3  2  1     3  1        1        1     3  2     3  2  1  1|             
      Duct, Cyst, Focal                    |                                                                          |             
      Duct, Cyst, Focal, Multiple          |                                                                          |             
      Duct, Hyperplasia, Cystic, Focal     |                         2                                2               |             
      Duct, Hyperplasia, Cystic            |                                                                         2|             
      Duct, Hyperplasia, Focal             |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Erosion                              |    2                                                                     |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              | 3  2                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Glands, Hyperplasia, Cystic, Focal   |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |       +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                    1                     |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2                                            2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Hyperplasia, Focal                   |             2  3     2                                2  2               |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphoid      |                                                                      2   |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                                                        |             
      Hyperplasia, Focal                   |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2                                                           3      |             
      Pars Distalis, Cyst                  |                                                          2               |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                | 2                                1                                       |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Pars Intermedia,      |                                                                          |             
          Angiectasis                      |             3                                                            |             
      Pars Intermedia, Cyst                |                   1                                                      |             
      Pars Intermedia, Hyperplasia, Focal  |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      C-Cell, Hyperplasia                  | 2     2  2  1  1  2  2  1  2  2     1  1  1  2  2  2  3  2  2  2  2  2  2|             
      Follicle, Mineralization, Focal      | 1     1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Follicular Cell, Hyperplasia         |                1  1     1              1     1  1  1     1        2  1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              | +                                         +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic                |                         2     1  1  1     2  1           2               |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |             1                    2        1           3  2               |             
      Epithelium, Hyperplasia, Focal       |                         2                    1                           |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                          4                     |             
      Bilateral, Atrophy                   |    3  4                                                                  |             
      Germinal Epithelium, Atrophy         |                                  3                                       |             
      Interstitial Cell, Hyperplasia, Focal|       1                                   2           1                  |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                   3      |             
      Hyperplasia                          |                   3                                                      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |             3                                                            |             
      Mediastinal, Hemorrhage              |             3                                                            |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                              1                           |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                         3                                                |             
      Pancreatic, Hyperplasia, Histiocytic |       3  3           3  3        3  3                 3                 3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2        3                                                         |             
      Hyperplasia, Histiocytic             |                3                                                         |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Infarct                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Epithelial Cell, Cyst, Multiple      |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Epithelium, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Angiectasis, Focal                   |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                          2               |             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                      2                                                   |             
      Hyperplasia, Histiocytic             |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                                  2                                       |             
      Metaplasia, Focal, Osseous           |                                        1              2                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       2  1                                   1        2                 2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                         2                                                |             
      Nasolacrimal Duct, Inflammation      | 2                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                        2           2           3         |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Inflammation, Suppurative     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2|             
                                           | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Cornea, Inflammation, Focal          |                                                                          |             
      Cornea, Necrosis, Focal              |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retrobulbar, Inflammation, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                           1                              |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                        2                                 |             
      Infarct                              | 3                                                                        |             
      Nephropathy                          |       2  1  1  1  2  1  1  1  1     1  2  1  1  1  1  1  1  1  1  1  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                           1                              |             
      Renal Tubule, Pigmentation           |                                           1                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X        X  X        X        X  X  X           X  X        X     X|     23     |
      Degeneration, Cystic, Focal          |                                                    1                    2|      3  1.3|
      Hepatodiaphragmatic Nodule           |                                                    X           X         |      5     |
      Infiltration Cellular, Mixed Cell    |       2        2  2  2  2  2        2              2  2  2  1  2     1   |     30  1.9|
      Inflammation, Granulomatous          | 1              1                    1  1           1     1     1         |     11  1.2|
      Mixed Cell Focus                     |             X     X     X  X              X        X  X        X         |     16     |
      Bile Duct, Hyperplasia               | 3  1  3     4  3  3  3  2  2  1  3  2  3  3  3  3  3  2  3  1  3  3  3  3|     49  2.6|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |             2  2  2  2  2  2        1  2  2        2  2  1     2  2      |     30  1.8|
      Hepatocyte, Centrilobular, Necrosis  |          3                                                               |      2  2.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                  3                          3        2   |      4  2.8|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |       2                                                                  |      1  2.0|
      Serosa, Fibrosis, Focal              |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|  46        |
      Fat, Necrosis, Focal                 |                3  3  3              3                 3                 3|     10  2.7|
      Fat, Necrosis                        |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  4.0|
      Acinus, Atrophy, Focal               | 2     3     1           2  1     2           2           1     1     2  3|     27  1.9|
      Duct, Cyst, Focal                    |                                              4                           |      1  4.0|
      Duct, Cyst, Focal, Multiple          |                                                 2        2               |      2  2.0|
      Duct, Hyperplasia, Cystic, Focal     |                                                                          |      2  2.0|
      Duct, Hyperplasia, Cystic            |                                                                          |      1  2.0|
      Duct, Hyperplasia, Focal             |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                   1                                                      |      1  1.0|
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                                              2                           |      1  2.0|
      Epithelium, Hyperplasia              |                                              3                           |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                  1                                       |      1  1.0|
      Glands, Hyperplasia, Cystic, Focal   |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |    +                                         +                           |   2        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Malformation                         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +     +     +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +     +|  40        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                   1           1                       2     2            |      5  1.6|
      Infiltration Cellular, Mixed Cell    |                                                                      2   |      1  2.0|
      Thrombosis                           |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      2  1           1                                    |      4  1.3|
      Cytoplasmic Alteration, Focal        |                                     1                                    |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |       1        1                    1  2              1        1  2      |      9  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      5  2.2|
      Hyperplasia                          |                                                          1               |      1  1.0|
      Infiltration Cellular, Lymphoid      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                          2               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |             1              1              1                              |      4  1.3|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |    2                                                        2            |      4  1.8|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                                                          2               |      1  2.0|
      Pars Distalis, Pars Intermedia,      |                                                                          |            |
          Angiectasis                      |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                      2   |      2  1.5|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 1  2  3     2  2  1  2  1  2        1  2  2     2  1  1     1  2  2  2  1|     43  1.7|
      Follicle, Mineralization, Focal      | 1  1  1     1  2  2  1  1  1        1  1  1  1  1  1  1  1  1  1  1  1  1|     45  1.0|
      Follicular Cell, Hyperplasia         |       1        1  1  1  2  1                                            1|     17  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                              +                       +   |   3        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                          +               |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      3   |      1  3.0|
      Granuloma Sperm                      |                                           2                              |      1  2.0|
      Inflammation, Chronic                |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                              +                           |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                            1                                             |      1  1.0|
      Inflammation, Chronic                | 1                 3                                               2      |     10  1.6|
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                    1                     |      1  1.0|
      Inflammation, Chronic                |             3                       1  2        2           2            |     10  1.9|
      Epithelium, Hyperplasia, Focal       |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                   4     4|      4  3.8|
      Bilateral, Atrophy                   |       3                                                                  |      3  3.3|
      Germinal Epithelium, Atrophy         |                                        3                             4   |      3  3.3|
      Interstitial Cell, Hyperplasia, Focal|                                                             2            |      4  1.5|
      Interstitial Cell, Hyperplasia       |                                     1                    2               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                      3   |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                                                      3   |      1  3.0|
      Pancreatic, Ectasia                  |                3        3                                                |      3  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                3           3           3                             3   |     12  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Histiocytic             |                                                                      3   |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |    2                                                        3        3   |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                      3   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    3                     |      1  3.0|
      Epithelial Cell, Cyst, Multiple      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Dilatation                           |                                        2                                 |      1  2.0|
      Epithelium, Pigmentation             |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                        3                                 |      2  2.5|
      Hemorrhage, Focal                    |          3                    4              3                           |      3  3.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Necrosis, Focal                      |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                             1        2   |      3  1.7|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                           1        2           2        1|      9  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |    2                                                                     |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      3  2.3|
      Sinus, Foreign Body                  |             3                                                            |      1  3.0|
      Sinus, Inflammation, Suppurative     |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cornea, Inflammation, Focal          |    2                                                                     |      1  2.0|
      Cornea, Necrosis, Focal              |    1                                                                     |      1  1.0|
      Lens, Cataract                       |                               2                                          |      1  2.0|
      Retrobulbar, Inflammation, Focal     |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3|            |
                                           | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    300 PPM                                | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                              3                           |      1  3.0|
      Cyst                                 |                                                       3                  |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy                          | 1  3  1     2  1  1  1  1  2        1  2  1     2  1  2  1  3  1  1  2  1|     43  1.3|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                             2        3   |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 3                                                                        |             
      Basophilic Focus                     |       X  X     X                             X                 X         |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                          2               |             
      Eosinophilic Focus                   |             X     X              X              X                        |             
      Fibrosis, Focal                      |          3                                                               |             
      Hepatodiaphragmatic Nodule           |                   X                                                     X|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular, Mixed Cell    |       2        2     2  2  2        1     2  2        2        2     2  2|             
      Inflammation, Granulomatous          |                         2              1                             2   |             
      Mixed Cell Focus                     |       X  X  X     X  X  X  X        X     X  X                          X|             
      Necrosis, Focal                      |          3                                                  2            |             
      Pigmentation, Focal                  |          3  2                                                            |             
      Bile Duct, Hyperplasia               | 3  3  2  3  3  2  3  3  3  3  2  2  3  3  3  2  4  3  3  2  3  2     2  3|             
      Centrilobular, Congestion            |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                                                          2        2      |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |       2  3     2     2  2  2        1     2  1     1  2        1     1  2|             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                             3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +     +  +     +  +|             
      Fat, Necrosis, Focal                 | 2     2     3           3           3  3     4  2           3            |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Atrophy, Focal                       |                2                                                         |             
      Acinus, Atrophy, Focal               | 2     2                 2                 2     1  1           4  1  2   |             
      Acinus, Hyperplasia, Focal           |                                                                3         |             
      Duct, Cyst, Focal, Multiple          |                                     2                                    |             
      Duct, Hyperplasia, Cystic, Focal     |                            2                                   2     2   |             
      Duct, Hyperplasia, Cystic            |          2                                                               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                         1                                                |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                             3            |             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Focal, Suppurative              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +  +  +  +  +  +     +                 +  +        +     +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Focal                |                                                                          |             
      Cardiomyopathy                       |                               2     2        2                           |             
      Congestion                           |                                                          3               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1        1  1                    1                                       |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                   1  1                 1  2        2  1              1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                3         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Pars Distalis, Angiectasis           |                            2                                             |             
      Pars Distalis, Cyst                  |                                           3     2                        |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                     1                                    |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Inflammation, Chronic,|                                                                          |             
           Focal, Granulomatous            |                                        2                                 |             
      Pars Intermedia, Hemorrhage          |                                                                          |             
      Pars Nervosa, Infiltration Cellular, |                                                                          |             
           Focal, Mixed Cell               | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1  1  2  1  1  1  1  2     1  2     1  2  1  1  2        3     1  1|             
      Follicle, Mineralization, Focal      | 1  1  1  1  1  1  3  1  1  3     3  3  3  1  2  3  1  2     2  1     2  3|             
      Follicular Cell, Hyperplasia         | 1  1  2     1  1  1  1  1        1  1  1  1  1  1  2  1     1  1     2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                   +                    +                    +            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |          +                                                               |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                             3            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2     2                                2  1     2                    2   |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                    1     1  1                             1  2         |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3        3                    3     3              3        3         |             
      Bilateral, Atrophy                   |                                                                      3   |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                        2  2                              |             
      Interstitial Cell, Hyperplasia       |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |       3                                                                  |             
      Mediastinal, Hemorrhage              |       3  3                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |                3                                                         |             
      Pancreatic, Ectasia                  |                         3                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Hemorrhage               |                         2                                                |             
      Pancreatic, Hyperplasia, Histiocytic |       3              3              3     3  3                 3     3  3|             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                             2            |             
      Fibrosis, Focal                      |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Inflammation, Granulomatous          |                                                                      3   |             
      Necrosis, Focal                      |    2                                                                     |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  M  +  +  +|             
      Dilatation                           |                                                    2                     |             
      Ectasia                              |                               3                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic, Focal         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                               2                                          |             
      Hemorrhage, Focal                    |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Histiocytic             |                                                          1               |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       1        1         |             
      Interstitium, Edema                  |                               2                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             
      Nasolacrimal Duct, Inflammation      |                                              3                           |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Cataract                             |                                                                          |             
      Synechia                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                      2   |             
      Inflammation, Chronic, Focal         |                                           1                              |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1  2        2     1  1|             
      Pelvis, Inflammation, Chronic        |                                           3                              |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                           3                              |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                        3                                 |             
      Renal Tubule, Pigmentation           |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Basophilic Focus                     |    X                                      X                 X            |      8     |
      Congestion                           |                   3                             3                        |      2  3.0|
      Degeneration, Cystic, Focal          |                                        2                                 |      2  2.0|
      Eosinophilic Focus                   |                                        X     X                           |      6     |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                    X              X      |      4     |
      Hyperplasia, Focal, Lymphoid         |                                                                   2  2   |      2  2.0|
      Infiltration Cellular, Mixed Cell    | 2  2  2  2  2  2  2        2        2     2     1     2  2     2  2      |     27  1.9|
      Inflammation, Granulomatous          |       2                                                                  |      4  1.8|
      Mixed Cell Focus                     |    X     X  X  X           X           X  X              X  X  X  X  X   |     23     |
      Necrosis, Focal                      |                                                                          |      2  2.5|
      Pigmentation, Focal                  |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               | 2  3  3  3  3  3  2     3     4  3  2  1  3  3  1  3  3  2  3  3  3  3  2|     47  2.7|
      Centrilobular, Congestion            |                         3                                                |      1  3.0|
      Hepatocyte, Necrosis, Focal          |                                                                         2|      3  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Cytoplasmic, Focal               |    1  1  2  2              2              2           1  2  2  2  2  2   |     26  1.7|
      Hepatocyte, Centrilobular, Necrosis  | 2                    3                                                   |      2  2.5|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                2                                                         |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +              +        +  +  +     +  +  +     +  +     +        +  +|  35        |
      Fat, Necrosis, Focal                 | 3  2                             3                 2  3     3        3   |     16  2.8|
      Fat, Necrosis                        |                   2                                                     3|      2  2.5|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Diffuse                     |                                        3                                 |      1  3.0|
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Acinus, Atrophy, Focal               | 1  2  2  3     2        2        3                 3        3  1  1      |     20  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Duct, Cyst, Focal, Multiple          |       2  2                                               2  2            |      5  2.0|
      Duct, Hyperplasia, Cystic, Focal     |                                                                          |      3  2.0|
      Duct, Hyperplasia, Cystic            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                2         |      2  1.5|
      Ulcer                                |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                                                          |      1  3.0|
      Erosion                              |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Focal, Suppurative              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                            +           +  +  +        +                  |  20        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Focal                |                   2  2                                                   |      2  2.0|
      Cardiomyopathy                       |       2        2                                   2     2  2     2  2   |     10  2.0|
      Congestion                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       1                    1                 1              1        2   |      9  1.1|
      Cytoplasmic Alteration, Focal        |                                                 1                        |      1  1.0|
      Degeneration, Cystic, Focal          |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |       2  1                                                  1            |     10  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                        2     1                           |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                2                    4                                    |      3  2.7|
      Pars Distalis, Angiectasis           |                                           2                              |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                             2            |      2  1.5|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                                          2               |      1  2.0|
      Pars Distalis, Inflammation, Chronic,|                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
           Focal, Granulomatous            |                                                                          |      1  2.0|
      Pars Intermedia, Hemorrhage          |                                              2                           |      1  2.0|
      Pars Nervosa, Infiltration Cellular, |                                                                          |            |
           Focal, Mixed Cell               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  43        |
      C-Cell, Hyperplasia                  |    1  2  1     1        2  1     1  3  2  2  1  2        2  2  2  2  2  2|     38  1.5|
      Follicle, Mineralization, Focal      | 1  3  1  3  1  1        1  3     1  3  2  3  1  2     3  3  1  1  3  2  1|     43  1.9|
      Follicular Cell, Hyperplasia         | 1  1  1  1  1  1        1  1           1  1  1        2  1  1  1  1  1   |     37  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                         +     +                 +                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                         4                                                |      1  4.0|
      Inflammation, Chronic                |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                                        3                                 |      2  3.0|
      Hyperplasia                          |                            2                                             |      1  2.0|
      Inflammation, Chronic                |       2  1  1  2                                                         |     10  1.7|
      Inflammation, Suppurative            |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  1  2  2  2  1  2              2  2              2        1         |     17  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Atrophy                              |             3                 4  3                 3     3           3   |     13  3.1|
      Bilateral, Atrophy                   |                                     3                                    |      2  3.0|
      Germinal Epithelium, Atrophy         |                                              3                           |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                                                          1              1|      4  1.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                         3                                                |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +        +  +|  42        |
      Hyperplasia, Lymphoid                |                                                       3                  |      1  3.0|
      Mediastinal, Congestion              |                   4                                                      |      1  4.0|
      Mediastinal, Ectasia                 |       3                                                     3            |      3  3.0|
      Mediastinal, Hemorrhage              |       3                                               3                 3|      5  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                                     3                                2   |      3  2.7|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic |    3  3  2  3                       3                 2     3            |     15  2.9|
      Pancreatic, Hyperplasia, Lymphoid    |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M|   2        |
      Hyperplasia, Plasma Cell             |                                     4                                    |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Hyperplasia, Histiocytic             |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                  3                                       |      2  2.5|
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hemorrhage                           |                                                    3                     |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                   2      |      2  2.5|
      Inflammation, Granulomatous          |       3                                                                  |      2  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation                         |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  M|  44        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Dilatation                           |                                     3                 2                  |      3  2.3|
      Ectasia                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                             X            |      1     |
      Inflammation, Chronic, Focal         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                   3                 4                 3                  |      4  3.0|
      Hemorrhage, Focal                    |                                                                         3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                         +|   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Hemorrhage, Focal                    |                                                                         3|      1  3.0|
      Mineralization, Focal                |                                                                         2|      1  2.0|
      Necrosis, Focal                      |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                                                          +               |   1        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   3                                                      |      1  3.0|
      Hemorrhage, Focal                    |                                                                         3|      1  3.0|
      Hyperplasia, Histiocytic             |                         1                                                |      2  1.0|
      Infiltration Cellular, Mixed Cell    | 3                                                                        |      1  3.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2                          2     2  2                              |      6  1.7|
      Interstitium, Edema                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
      Cataract                             |                                                          2               |      1  2.0|
      Synechia                             |                                                          3               |      1  3.0|
      Retina, Degeneration                 |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |       1                                                                  |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8|            |
                                           | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Nephropathy                          | 1  2  1  1  1  1        2  1     1     2  1  1        1  1  1  1  1  1  2|     41  1.2|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                     2           4                        |      3  3.0|
      Renal Tubule, Pigmentation           |                         2                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cholangiofibrosis                    |                                                    2                     |             
      Congestion                           |                                                 3                        |             
      Degeneration, Cystic, Focal          |          1                 2  2     2                          2         |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hepatodiaphragmatic Nodule           |                               X              X           X        X      |             
      Hyperplasia, Focal, Lymphoid         |                                                    3                     |             
      Infiltration Cellular, Mixed Cell    |       2        2  2  2  2  1  2  2     2  1  2           2     2  2  2  2|             
      Inflammation, Granulomatous          |                1        1                 1        3           1     1   |             
      Mixed Cell Focus                     |                X  X  X  X              X     X        X        X  X  X  X|             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 3  2  2  2  3  3  3  3  3  3  3  3  4  2  3  3  3  2  3  3  3  3  3  3  3|             
      Hepatocyte, Necrosis, Focal          |          2                                                               |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                1  2  2  2     2  1        1  1                    2  1  2|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |             2                                         3                  |             
      Oval Cell, Hyperplasia               |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +     +  +  +  +                 +        +  +     +  +     +        +|             
      Fibrosis, Focal                      |                                                                         3|             
      Hemorrhage                           |                                                                         3|             
      Necrosis, Focal                      |                                                                         3|             
      Artery, Inflammation, Chronic        |                                                 3                        |             
      Fat, Necrosis, Focal                 |             3                                2           3     3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    2                                                                     |             
      Fibrosis, Focal                      |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               | 2     2  3  2  1  1  3  1  2  1  2  3  2  1     2  1  2     2  1         |             
      Duct, Cyst, Focal, Multiple          |                            2              2     2     2  2        2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Erosion                              |                                  1                                       |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |       2                                                                  |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
      Epithelium, Hyperplasia              |       3                                         2                        |             
      Serosa, Foreign Body                 |                                  1                                       |             
      Serosa, Inflammation, Chronic, Focal |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Necrosis, Focal          |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +     +  +  +  +                 +        +                           |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Focal                |                                                                          |             
      Cardiomyopathy                       |                            1                       2                     |             
      Fibrosis                             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                     2                       1        2   |             
      Cytoplasmic Alteration, Focal        |                                                 1                        |             
      Vacuolization Cytoplasmic, Focal     |    1                             1           1                       1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       1                       1  2                    1                  |             
      Hyperplasia                          |          2                                                               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2                                                                  |             
      Pars Distalis, Cyst                  |                                                             1        2   |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                 1        1  1            |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                    2                     |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  2  2  2  2  2     2  2              1  2  3  2                    2|             
      Follicle, Cyst                       |                                                                X         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicle, Mineralization, Focal      | 3  3  3  3  3  3  3  3  3  2  3  3  3  2  2  3  2  2  3  3  3  3  3  3  3|             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                     2                                    |             
      Follicular Cell, Hyperplasia         |       1  1  2  2  2  3  2  2  3  2  2  1  1  2  2  1  1  3  2  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Thoracic, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Granuloma Sperm                      |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                2                                                         |             
      Hyperplasia, Cystic                  |       4                                                                  |             
      Inflammation, Chronic                |                                     2        3  2  3        2            |             
      Inflammation, Suppurative            |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                      1  3     1        1  1  3     1|             
      Epithelium, Hyperplasia, Focal       |                   1  1                                                   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3        4        3     3        3  3              3           3      |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia, Focal               |                                                             1            |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                1                    1  2                             1   |             
      Interstitial Cell, Hyperplasia       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |       3  3                 3                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                           3                              |             
      Mediastinal, Hyperplasia, Histiocytic|                      2                 3  3                              |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                        3                                 |             
      Pancreatic, Angiectasis              |                                                    3                     |             
      Pancreatic, Ectasia                  |                                                                3         |             
      Pancreatic, Hemorrhage               |                                                    3                     |             
      Pancreatic, Hyperplasia, Histiocytic |          3        3  3        3  3     3           3           3  2  3  3|             
      Pancreatic, Hyperplasia, Lymphoid    |       2                                                                  |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                                      3         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                         3                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |       3  3                             2                                 |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Granulomatous          |                                                             2            |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Mammary Gland                           | +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             2                                                     3      |             
      Hyperplasia, Cystic                  |                                              3                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                         3|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |                                                    2                     |             
      Subcutaneous Tissue, Cyst            |                                                    2                     |             
      Subcutaneous Tissue, Foreign Body    |                                                                   3      |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                   2      |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |                                                                          |             
      Glands, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    | 2                                                                        |             
      Hyperplasia, Histiocytic             |                                                 1                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Focal, Mixed  |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Metaplasia, Focal, Osseous           |             1     1                                                      |             
      Metaplasia, Osseous                  |                                                                1  1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                1        2                                               2|             
      Alveolus, Foreign Body, Focal        |                                                                          |             
      Interstitium, Edema                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                          1               |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                   3      |             
      Inflammation, Focal, Granulomatous   |                                                    1                     |             
      Epithelium, Hyperplasia, Focal       |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                 2                        |             
      Cyst                                 |                         3              1                                 |             
      Fibrosis, Focal                      |                                                 2                        |             
      Nephropathy                          | 2  1  1  1     1  1  1     1  1     1  1  1  1  2  1  2  1  1  1  1  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                       3                  |             
      Renal Tubule, Pigmentation           |                                                       3                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3|             
                                           | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3000 PPM                               | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X                                                                  |      2     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |       1                                                                 2|      7  1.7|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                            1                                             |      2  1.0|
      Hepatodiaphragmatic Nodule           | X           X     X     X                             X                  |      9     |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |    2  2  2  2  2  2  1  2     2  2     2  2  2  2  2     2  2  2  2  2   |     36  1.9|
      Inflammation, Granulomatous          | 1                 1     2     1                          2               |     11  1.4|
      Mixed Cell Focus                     | X  X  X  X  X                    X     X     X  X  X     X  X  X  X  X   |     26     |
      Necrosis, Focal                      |                                     2                                    |      1  2.0|
      Bile Duct, Cyst                      | X                                                                        |      1     |
      Bile Duct, Hyperplasia               | 3  3  2  3  3  3  3  1  2     2  3  2  3  2  3  3  3  1  3  3  3  3  3  4|     49  2.8|
      Hepatocyte, Necrosis, Focal          |                         1                                                |      2  1.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                           2                              |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Cytoplasmic, Focal               |    2  2  2  2  1  1              2     2     2  1           2     1      |     23  1.6|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                2         |      3  2.3|
      Oval Cell, Hyperplasia               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +              +        +     +  +                       +  +|  20        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hemorrhage                           |                            4                                             |      2  3.5|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |    3        3                             3  3                       2  2|     10  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                     3                                    |      1  3.0|
      Acinus, Atrophy, Diffuse             |                                     3                                    |      1  3.0|
      Acinus, Atrophy, Focal               | 3  3  1     2  1  2  2        2  3     2  3  1  2     3  3           3  2|     36  2.0|
      Duct, Cyst, Focal, Multiple          | 2              2  2                    1     3                    1      |     12  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                1         |      1  1.0|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                             2            |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                  2                                       |      1  2.0|
      Ulcer                                |                      2        2  2                                       |      4  2.0|
      Epithelium, Hyperplasia, Focal       |       2                                                                  |      1  2.0|
      Epithelium, Hyperplasia              |                               2  2                 2           1         |      6  2.0|
      Serosa, Foreign Body                 |                                                                          |      1  1.0|
      Serosa, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Epithelium, Necrosis, Focal          |                                     1                                    |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |    +                                                                     |   1        |
      Epithelium, Hyperplasia, Focal       |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +                                         +                              |   9        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Focal                |                      2                                                   |      1  2.0|
      Cardiomyopathy                       |       2  2                                         3                     |      5  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                   2                 1                                    |      5  1.6|
      Cytoplasmic Alteration, Focal        |                                     2                                1   |      3  1.3|
      Vacuolization Cytoplasmic, Focal     |          2                                2              2  2  1     1   |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    2  2                                                        1         |      7  1.4|
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                   3      |      3  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1                                                  1      |      5  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                                                   1      |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |                   1                                                      |      2  1.5|
      Pars Intermedia, Cyst                |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  2  2  1     2  2     2     1  2  2  1     1  2  2  2  1  2  2  1     2|     34  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Mineralization, Focal      | 3  3  3  3  3  3  3  1     1  1  3  1  3  1  2  3  3  3  3  3  3  3  3  3|     49  2.7|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         | 1  1  1  2  2  1  3  2  2  3  1  2     3     2  2  2  2  1        2  1   |     43  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                      +              +                                   +|   4        |
      Mediastinum, Hemorrhage              |                      3                                                   |      1  3.0|
      Thoracic, Hemorrhage                 |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                                  |      1  2.0|
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                               3                                          |      2  2.5|
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic                | 2     1  1              3     1                 2                        |     11  2.0|
      Inflammation, Suppurative            |                                           3                              |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  2     2  1  1  1           2     1     3  1                 2         |     19  1.5|
      Epithelium, Hyperplasia, Focal       |             1                 2     1                                    |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3           3              3        4                              |     13  3.2|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia, Focal               |                                  2                                       |      2  1.5|
      Germinal Epithelium, Atrophy         |                                                       3                  |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|    1                                2           2           2     2      |      9  1.6|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                                           3                          3   |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +           +        +  +  +  +  +  +     +  +  +     +     +|  38        |
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Mediastinal, Ectasia                 |                                              3                           |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                 3                        |      4  2.8|
      Mediastinal, Hyperplasia, Lymphoid   | 3                                                                        |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |             3                                                            |      2  3.0|
      Pancreatic, Hemorrhage               |                         2           3     3                              |      4  2.8|
      Pancreatic, Hyperplasia, Histiocytic | 3        3                       3     2     3           3  3     3      |     19  2.9|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Pigmentation             |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      2  3.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Hyperplasia, Histiocytic             |                         3  2                                3            |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          3               |      1  3.0|
      Fibrosis, Focal                      |                                     2                                    |      1  2.0|
      Hematopoietic Cell Proliferation     |                      2                    3                          2   |      6  2.5|
      Hemorrhage, Focal                    |                                                       3                  |      1  3.0|
      Inflammation, Granulomatous          |             1     2                                                      |      3  1.7|
      Necrosis, Focal                      |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  I  +  +  +  +  +|  42        |
      Dilatation                           |                                                                          |      2  2.5|
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |       2                                                                  |      1  2.0|
      Inflammation, Chronic, Focal         | 2                                                                        |      1  2.0|
      Necrosis, Focal                      |       2                                                                  |      1  2.0|
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Cyst            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Subcutaneous Tissue, Foreign Body    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +  +                             +           +                  |   4        |
      Fibrosis, Focal                      |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                   +                                                      |   1        |
      Glands, Hyperplasia, Focal           |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      2                                                   |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                               1                                          |      2  1.0|
      Infiltration Cellular, Focal, Mixed  |                                                                          |            |
          Cell                             |                   3                                                      |      1  3.0|
      Inflammation, Focal                  |                      3                                                   |      1  3.0|
      Metaplasia, Focal, Osseous           |                                                                          |      2  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2     2                                                               |      5  1.8|
      Alveolus, Foreign Body, Focal        |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 92012-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 03/14/03    
Route: DOSED FEED                                                                                                 Time: 10:39:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3000 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Interstitium, Edema                  |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                3                                3                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                         1     1                                          |      2  1.0|
      Inflammation, Chronic, Focal         |             1                          1                                 |      3  1.7|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      2  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  1  1  1  1  2  2  1  2  2  1  1  1  3  1  1     3  1  1  1  1  1  1|     46  1.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                            3                                             |      2  3.0|
      Renal Tubule, Pigmentation           |                            2        2                                    |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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