TDMS Study 92012-05 Pathology Tables
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
FINAL#1; REVISION#1
Facility: Southern Research Institute
Chemical CAS #: 693-98-1
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Natural Death 4 3 10 1
Moribund Sacrifice 6 8 12 7
Survivors
Terminal Sacrifice 40 39 28 41
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (47) (44) (50)
Edema 1 [3.0]
Intestine Small, Jejunum (47) (46) (44) (49)
Necrosis, Focal 1 [3.0]
Liver (50) (49) (50) (50)
Angiectasis, Focal 2 [2.0] 1 [2.0] 2 [3.5]
Basophilic Focus 42 44 43 39
Cholangiofibrosis 1 [2.0]
Congestion 2 [2.5] 1 [4.0]
Congestion, Focal 1 [2.0]
Degeneration, Cystic, Focal 1 [2.0] 2 [2.0]
Eosinophilic Focus 1
Fatty Change 2 [3.0] 1 [2.0]
Hemorrhage 2 [2.0] 2 [2.0]
Hepatodiaphragmatic Nodule 6 11 14 13
Hyperplasia, Focal, Lymphoid 1 [3.0] 1 [2.0]
Infarct 2
Infiltration Cellular, Mixed Cell 42 [1.7] 44 [2.0] 34 [1.9] 38 [1.9]
Inflammation, Granulomatous 18 [1.6] 23 [2.0] 22 [1.5] 42 [2.1]
Mixed Cell Focus 15 14 11 26
Necrosis, Focal 1 [2.0] 1 [2.0]
Bile Duct, Cholangiofibrosis, Focal 1 [2.0]
Bile Duct, Cyst 2
Bile Duct, Cyst, Multiple 1 1
Bile Duct, Hyperplasia 20 [1.3] 29 [1.4] 20 [1.5] 40 [1.9]
Hepatocyte, Necrosis, Focal 1 [2.0] 2 [2.0]
Hepatocyte, Vacuolization Cytoplasmic, Focal 9 [1.4] 10 [1.4] 11 [1.2] 9 [1.8]
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Centrilobular, Necrosis 1 [3.0] 1 [3.0]
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 [4.0] 4 [3.0] 1 [2.0]
Mesentery (8) (10) (12) (9)
Fibrosis 1 [1.0]
Hemorrhage, Focal 1 [2.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Inflammation, Chronic 1 [2.0]
Artery, Inflammation, Chronic, Focal 1 [3.0]
Fat, Necrosis 1 [2.0] 2 [2.5]
Fat, Necrosis, Focal 5 [2.0] 7 [2.7] 6 [2.8] 3 [2.0]
Pancreas (50) (49) (49) (50)
Infiltration Cellular, Diffuse, Mixed Cell 1 [2.0]
Acinus, Atrophy, Diffuse 1 [3.0] 1 [4.0] 1 [2.0]
Acinus, Atrophy, Focal 13 [1.6] 14 [1.2] 13 [1.7] 11 [1.9]
Duct, Cyst, Focal 1 [2.0] 1 [2.0]
Duct, Cyst, Focal, Multiple 9 [1.8] 12 [1.9] 4 [2.0] 5 [1.8]
Salivary Glands (50) (49) (50) (50)
Duct, Mineralization, Focal 2 [2.5]
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 [2.0] 1 [2.0] 2 [1.5]
Edema 1 [3.0]
Erosion 1 [2.0]
Inflammation, Chronic 1 [3.0] 1 [3.0]
Inflammation, Focal 1 [2.0]
Ulcer 2 [2.5] 1 [2.0] 1 [2.0]
Epithelium, Hyperplasia 3 [1.3] 1 [2.0] 4 [2.5] 1 [2.0]
Stomach, Glandular (49) (49) (48) (50)
Erosion 1 [2.0] 1 [2.0]
Inflammation, Chronic 1 [2.0]
Necrosis, Focal 1 [2.0]
Ulcer 1 [2.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
Glands, Degeneration, Cystic, Focal 1 [1.0]
Glands, Ectasia, Focal 1 [2.0]
Glands, Hyperplasia, Focal 2 [2.0]
Tongue (3) (1)
Epithelium, Hyperplasia, Focal 1 [1.0]
Tooth (1)
Peridontal Tissue, Inflammation, Chronic 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Cardiomyopathy 5 [1.4] 8 [1.9] 7 [1.6] 6 [1.7]
Infiltration Cellular, Mixed Cell 4 [1.5] 3 [2.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Accessory Adrenal Cortical Nodule 2 [1.0] 2 [1.0] 5 [1.2] 5 [1.0]
Angiectasis 1 [2.0] 1 [3.0] 1 [2.0] 2 [2.0]
Cytoplasmic Alteration, Focal 3 [1.7] 1 [1.0] 5 [1.4]
Hematopoietic Cell Proliferation 1 [2.0]
Hemorrhage 1 [2.0]
Hemorrhage, Focal 1 [2.0]
Vacuolization Cytoplasmic, Focal 8 [1.8] 3 [2.0] 7 [1.9] 12 [1.6]
Adrenal Medulla (49) (49) (50) (50)
Hyperplasia, Focal 1 [2.0] 1 [2.0] 1 [1.0] 2 [1.0]
Pituitary Gland (50) (48) (50) (50)
Angiectasis 5 [2.8] 9 [2.6] 7 [2.7] 2 [3.0]
Cyst 1 [3.0]
Hemorrhage 1 [3.0]
Metaplasia, Focal, Lipocyte 1 [2.0]
Pars Distalis, Angiectasis 1 [2.0]
Pars Distalis, Cyst 1 [3.0] 3 [2.3] 2 [2.0] 1 [2.0]
Pars Distalis, Cyst, Multiple 2 [2.5]
Pars Distalis, Cytoplasmic Alteration, Focal 4 [1.5] 4 [1.5] 1 [2.0] 3 [1.7]
Pars Distalis, Degeneration, Cystic 1 [2.0]
Pars Distalis, Degeneration, Cystic, Focal 9 [2.2] 14 [2.1] 8 [2.4] 5 [2.2]
Pars Distalis, Hemorrhage, Focal 1 [1.0] 3 [2.7] 4 [3.0] 6 [2.7]
Pars Distalis, Hyperplasia, Focal 1 [2.0] 1 [2.0] 1 [3.0] 1 [2.0]
Pars Distalis, Pigmentation, Focal 1 [2.0]
Pars Intermedia, Cyst 1 [2.0] 3 [2.0]
Pars Intermedia, Degeneration, Cystic, Focal 1 [2.0]
Pars Intermedia, Hemorrhage 1 [2.0]
Pars Intermedia, Pars Nervosa, Atypia
Cellular, Focal 1 [2.0]
Rathke's Cleft, Cyst 1 [3.0] 1 [2.0]
Rathke's Cleft, Hemorrhage 2 [3.0]
Thyroid Gland (49) (48) (42) (48)
Vacuolization Cytoplasmic, Focal 1 [1.0]
C-Cell, Hyperplasia 48 [2.2] 46 [2.2] 40 [2.0] 25 [1.7]
Follicle, Cyst 2 1
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Mineralization, Focal 42 [1.0] 47 [1.7] 41 [2.4] 48 [2.7]
Follicular Cell, Hyperplasia 41 [1.5] 34 [1.7] 46 [2.2]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (4) (2)
Mediastinum, Infiltration Cellular, Mixed
Cell 1 [3.0]
Pelvic, Hemorrhage, Focal 1 [3.0]
Thoracic, Infiltration Cellular, Focal,
Mixed Cell 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (50)
Degeneration, Cystic 6 [2.5] 4 [3.0] 1 [2.0] 1 [3.0]
Fibrosis, Focal 1 [2.0]
Hyperplasia, Cystic 1 [2.0] 4 [2.8] 3 [3.0] 1 [3.0]
Inflammation, Chronic 2 [3.0] 5 [2.2] 4 [2.3]
Ovary (50) (49) (50) (50)
Angiectasis 1 [2.0] 1 [2.0]
Atrophy 1 [3.0]
Congestion 1 [3.0]
Cyst 5 [2.0] 5 [2.8] 1 [2.0]
Bilateral, Cyst, Multiple 1 [4.0]
Periovarian Tissue, Cyst 4 [3.3] 5 [3.2] 4 [3.0] 6 [3.0]
Periovarian Tissue, Cyst, Multiple 1 [2.0]
Uterus (50) (50) (50) (50)
Cyst 3 [2.7] 1 [2.0] 1 [2.0]
Hemorrhage 2 [2.0]
Inflammation, Chronic 1 [3.0]
Cervix, Hyperplasia 1 [3.0]
Endometrium, Hyperplasia, Cystic 10 [1.7] 14 [1.8] 15 [1.6] 15 [1.6]
Vagina (2) (2)
Inflammation, Chronic 1 [2.0]
Epithelium, Cyst 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 1 [3.0]
Fibrosis 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [2.0] 4 [2.3]
Myelofibrosis 1 [3.0]
Necrosis 1 [2.0]
Myeloid Cell, Hyperplasia 2 [3.0] 3 [2.7] 5 [2.6] 2 [3.0]
Myeloid Cell, Erythroid Cell, Hyperplasia 2 [2.5] 1 [3.0]
Lymph Node (32) (31) (34) (41)
Deep Cervical, Hemorrhage 2 [3.0]
Mediastinal, Angiectasis 1 [3.0]
Mediastinal, Congestion 1 [3.0]
Mediastinal, Ectasia 5 [2.8] 3 [2.7] 2 [3.0] 7 [2.9]
Mediastinal, Hemorrhage 2 [2.0] 3 [3.0] 9 [2.8] 8 [2.9]
Mediastinal, Hyperplasia 1 [3.0] 2 [3.0]
Mediastinal, Hyperplasia, Histiocytic 8 [2.9] 8 [2.9] 5 [3.0] 12 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 1 [3.0]
Mediastinal, Pigmentation 1 [2.0] 2 [3.0]
Pancreatic, Atrophy 1 [3.0]
Pancreatic, Ectasia 2 [2.0] 2 [3.0] 11 [2.7]
Pancreatic, Hemorrhage 5 [2.6] 3 [3.0] 2 [2.5] 9 [3.0]
Pancreatic, Hyperplasia, Histiocytic 16 [2.8] 24 [2.8] 17 [3.0] 18 [3.1]
Pancreatic, Hyperplasia, Plasma Cell 1 [3.0]
Pancreatic, Infiltration Cellular, Mixed Cell 1 [3.0]
Pancreatic, Pigmentation 4 [2.8] 2 [2.5] 1 [3.0]
Lymph Node, Mandibular (5) (4) (5) (1)
Ectasia 1 [3.0]
Lymph Node, Mesenteric (49) (49) (49) (50)
Angiectasis 1 [3.0]
Ectasia 1 [3.0] 5 [3.0]
Hemorrhage 1 [2.0] 2 [3.0] 2 [3.0]
Hyperplasia, Histiocytic 2 [3.0] 1 [3.0] 2 [3.0] 2 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
Pigmentation 2 [2.5]
Spleen (50) (49) (48) (50)
Accessory Spleen 1 [1.0] 1 [2.0]
Angiectasis, Focal 1 [2.0]
Congestion 1 [3.0]
Fibrosis, Focal 1 [2.0] 1 [2.0]
Hematopoietic Cell Proliferation 6 [2.2] 8 [2.4] 5 [2.6] 4 [2.0]
Hemorrhage 1 [2.0]
Infarct 1 [3.0]
Inflammation, Granulomatous 3 [3.3] 2 [3.0] 4 [2.5] 27 [3.3]
Pigmentation 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Focal 1 [2.0] 1 [3.0] 1 [3.0]
Thymus (48) (45) (49) (49)
Angiectasis 2 [3.0]
Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 2 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Dilatation 33 [2.4] 35 [2.5] 22 [2.6] 19 [2.3]
Ectasia 2 [3.5] 3 [2.3] 7 [2.3]
Fibrosis 1 [3.0]
Hyperplasia 3 [2.3] 5 [2.6] 4 [2.0] 3 [2.0]
Hyperplasia, Cystic 1 [3.0] 2 [2.5]
Inflammation, Focal 1 [3.0]
Skin (50) (50) (50) (50)
Necrosis, Focal 4 [3.3]
Ulcer 1 [3.0] 1 [4.0]
Subcutaneous Tissue, Angiectasis, Focal 1 [2.0]
Subcutaneous Tissue, Hemorrhage, Focal 1 [3.0]
Subcutaneous Tissue, Inflammation, Focal,
Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Compression, Focal 10 [2.9] 8 [3.0] 12 [2.9] 4 [3.0]
Hemorrhage, Focal 2 [2.5] 1 [2.0] 2 [3.0]
Necrosis, Focal 2 [3.0]
Pigmentation, Focal 1 [2.0]
Cerebellum, Developmental Malformation 1 [3.0]
Spinal Cord (3) (1) (4)
Hemorrhage, Focal 1 [2.0]
Necrosis, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Congestion 2 [1.5] 4 [2.3] 2 [2.0] 2 [1.5]
Emphysema 1 [3.0]
Hemorrhage 1 [1.0]
Hemorrhage, Focal 1 [2.0] 2 [2.5]
Hyperplasia, Focal, Histiocytic 1 [1.0] 1 [3.0]
Hyperplasia, Histiocytic 6 [1.3] 6 [1.2] 7 [1.0] 1 [2.0]
Infiltration Cellular, Focal, Mixed Cell 1 [2.0]
Infiltration Cellular, Mixed Cell 3 [2.0] 1 [3.0] 6 [2.0]
Inflammation, Chronic, Focal 1 [1.0] 2 [1.0] 1 [2.0]
Inflammation, Focal, Granulomatous 1 [1.0] 1 [1.0]
Pigmentation, Focal 1 [2.0]
Alveolar Epithelium, Hyperplasia, Focal 7 [1.6] 5 [1.8] 3 [1.7] 3 [2.0]
Alveolus, Inflammation, Focal, Granulomatous 1 [2.0]
Interstitium, Edema 1 [3.0]
Nose (50) (49) (50) (50)
Foreign Body 1 [2.0] 1 [3.0]
Inflammation, Suppurative 1 [2.0] 1 [2.0] 2 [2.5]
Nasolacrimal Duct, Inflammation 4 [2.8] 2 [2.0] 4 [2.3]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (49) (49) (50)
Atrophy 1 [3.0] 1 [3.0] 1 [3.0]
Cataract 1 [3.0] 2 [3.0] 2 [1.5] 1 [3.0]
Iris, Synechia 1 [3.0]
Retina, Degeneration 2 [3.0] 1 [3.0] 1 [3.0]
Harderian Gland (50) (49) (50) (50)
Hyperplasia, Cystic, Focal 1 [2.0]
Hyperplasia, Focal 2 [1.0] 1 [2.0] 1 [1.0]
Hyperplasia, Focal, Histiocytic 1 [2.0] 2 [1.5] 1 [2.0] 4 [1.5]
Inflammation, Chronic, Focal 3 [1.3] 1 [3.0]
Inflammation, Focal, Granulomatous 1 [1.0]
Epithelium, Hyperplasia, Focal 2 [1.5] 2 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (47) (50)
Atrophy, Focal 2 [2.0] 1 [2.0]
Congestion 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cyst 1 [2.0]
Infarct 1 [2.0]
Nephropathy 38 [1.0] 40 [1.0] 38 [1.1] 40 [1.1]
Glomerulus, Amyloid Deposition, Diffuse 1 [3.0]
Pelvis, Inflammation 1 [2.0]
Renal Tubule, Accumulation, Hyaline Droplet 11 [2.2] 7 [2.0] 3 [2.3] 4 [2.5]
Renal Tubule, Pigmentation 8 [1.6] 4 [1.5] 5 [2.2]
Urethra (2)
Transitional Epithelium, Hyperplasia, Diffuse 1 [2.0]
Urinary Bladder (50) (49) (49) (50)
Transitional Epithelium, Hyperplasia 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 13 6 7 13
Natural Death 2 4 7 2
Survivors
Terminal Sacrifice 34 39 35 35
Moribund Sacrifice 1
Natural Death 1 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (48) (48) (50)
Angiectasis, Focal 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis, Focal 1 [3.0]
Basophilic Focus 23 23 8 2
Cholangiofibrosis 1 [4.0] 1 [2.0]
Congestion 2 [3.0] 1 [3.0]
Degeneration, Cystic, Focal 4 [1.8] 3 [1.3] 2 [2.0] 7 [1.7]
Eosinophilic Focus 3 6 1
Fibrosis, Focal 1 [3.0]
Hematopoietic Cell Proliferation 2 [1.0]
Hepatodiaphragmatic Nodule 6 5 4 9
Hyperplasia, Focal, Lymphoid 1 [2.0] 2 [2.0] 1 [3.0]
Infiltration Cellular, Mixed Cell 25 [2.0] 30 [1.9] 27 [1.9] 36 [1.9]
Inflammation, Granulomatous 12 [1.3] 11 [1.2] 4 [1.8] 11 [1.4]
Mixed Cell Focus 14 16 23 26
Necrosis, Focal 2 [2.5] 2 [2.5] 1 [2.0]
Pigmentation, Focal 2 [2.5]
Bile Duct, Cyst 1
Bile Duct, Hyperplasia 49 [2.7] 49 [2.6] 47 [2.7] 49 [2.8]
Centrilobular, Congestion 1 [3.0]
Hepatocyte, Necrosis, Focal 1 [4.0] 1 [1.0] 3 [2.0] 2 [1.5]
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 1 [2.0] 1 [2.0]
Hepatocyte, Vacuolization Cytoplasmic, Focal 23 [1.8] 30 [1.8] 26 [1.7] 23 [1.6]
Hepatocyte, Centrilobular, Necrosis 2 [2.5] 2 [2.5]
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 5 [2.8] 4 [2.8] 3 [2.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 1 [2.0] 1 [2.0] 2 [2.5]
Oval Cell, Hyperplasia 1 [2.0]
Serosa, Fibrosis, Focal 2 [2.5]
Mesentery (26) (46) (35) (20)
Fibrosis, Focal 1 [3.0]
Hemorrhage 2 [3.5]
Necrosis, Focal 1 [3.0]
Artery, Inflammation, Chronic 1 [3.0]
Fat, Necrosis 1 [2.0] 1 [3.0] 2 [2.5]
Fat, Necrosis, Focal 8 [2.9] 10 [2.7] 16 [2.8] 10 [2.7]
Pancreas (49) (49) (50) (50)
Atrophy, Diffuse 1 [3.0]
Atrophy, Focal 1 [2.0] 1 [2.0]
Fibrosis, Focal 1 [3.0]
Acinus, Atrophy, Diffuse 1 [4.0] 1 [3.0]
Acinus, Atrophy, Focal 22 [1.9] 27 [1.9] 20 [2.0] 36 [2.0]
Acinus, Hyperplasia, Focal 1 [3.0]
Duct, Cyst 1 [1.0]
Duct, Cyst, Focal 1 [4.0]
Duct, Cyst, Focal, Multiple 6 [2.7] 2 [2.0] 5 [2.0] 12 [1.9]
Duct, Hyperplasia, Cystic 1 [2.0] 1 [2.0]
Duct, Hyperplasia, Cystic, Focal 2 [2.0] 3 [2.0]
Duct, Hyperplasia, Focal 1 [2.0]
Salivary Glands (50) (50) (50) (50)
Atrophy, Focal 1 [1.0]
Inflammation, Chronic 1 [2.0]
Stomach, Forestomach (50) (50) (50) (49)
Diverticulum 1 [1.0] 1 [1.0] 2 [1.5] 1 [2.0]
Edema 1 [3.0]
Erosion 1 [2.0] 1 [1.0]
Inflammation, Focal 1 [2.0] 1 [2.0]
Ulcer 2 [1.5] 1 [2.0] 1 [2.0] 4 [2.0]
Epithelium, Hyperplasia 2 [2.0] 3 [2.7] 6 [2.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
Serosa, Foreign Body 1 [1.0]
Serosa, Inflammation, Chronic, Focal 1 [2.0]
Stomach, Glandular (50) (50) (50) (49)
Erosion 4 [1.8] 1 [1.0] 1 [2.0]
Erosion, Focal 1 [2.0] 1 [3.0]
Inflammation, Focal 1 [2.0]
Ulcer 2 [1.0]
Epithelium, Necrosis, Focal 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Glands, Hyperplasia, Cystic, Focal 1 [2.0]
Glands, Hyperplasia, Focal 1 [1.0]
Tongue (1) (2) (1)
Epithelium, Hyperplasia, Focal 1 [2.0]
Tooth (1) (1) (1) (2)
Malformation 1 [2.0]
Peridontal Tissue, Inflammation 1 [3.0]
Peridontal Tissue, Inflammation, Chronic 1 [2.0]
Peridontal Tissue, Inflammation, Focal,
Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 [1.7] 5 [1.6] 10 [2.0] 5 [2.0]
Cardiomyopathy, Focal 2 [2.0] 1 [2.0]
Congestion 1 [3.0]
Fibrosis 1 [2.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Thrombosis 1 [3.0] 1 [3.0]
Endocardium, Myocardium, Fibrosis, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 [2.0] 4 [1.3] 9 [1.1] 5 [1.6]
Cytoplasmic Alteration, Focal 2 [2.0] 1 [1.0] 1 [1.0] 3 [1.3]
Degeneration, Cystic, Focal 1 [2.0]
Hemorrhage 2 [1.5]
Vacuolization Cytoplasmic, Focal 6 [1.5] 9 [1.4] 10 [1.3] 10 [1.4]
Adrenal Medulla (50) (50) (50) (50)
Angiectasis 1 [2.0]
Hyperplasia 1 [2.0] 1 [1.0] 1 [2.0]
Hyperplasia, Focal 7 [1.3] 5 [2.2] 3 [1.3] 7 [1.4]
Infiltration Cellular, Lymphoid 1 [2.0]
Vacuolization Cytoplasmic, Focal 1 [2.0]
Islets, Pancreatic (50) (49) (50) (50)
Atrophy 1 [3.0]
Hyperplasia, Focal 2 [2.0] 1 [3.0] 1 [2.0]
Parathyroid Gland (47) (49) (48) (49)
Cyst 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [3.0]
Hyperplasia, Focal 1 [2.0] 1 [3.0]
Bilateral, Hyperplasia, Focal 1 [2.0]
Pituitary Gland (50) (50) (50) (50)
Angiectasis 2 [1.5] 3 [2.7]
Pars Distalis, Angiectasis 3 [2.3] 2 [2.5] 2 [2.0] 1 [2.0]
Pars Distalis, Cyst 1 [2.0] 4 [1.3] 2 [2.5] 3 [2.0]
Pars Distalis, Cytoplasmic Alteration, Focal 1 [1.0] 4 [1.8] 2 [1.5] 5 [1.0]
Pars Distalis, Degeneration, Cystic, Focal 1 [2.0] 1 [2.0] 1 [2.0] 1 [1.0]
Pars Distalis, Hyperplasia, Focal 2 [1.5] 1 [2.0] 2 [1.5]
Pars Distalis, Inflammation, Chronic, Focal,
Granulomatous 1 [2.0]
Pars Distalis, Pars Intermedia, Angiectasis 1 [3.0]
Pars Intermedia, Cyst 2 [1.5] 1 [2.0]
Pars Intermedia, Hemorrhage 1 [2.0]
Pars Intermedia, Hyperplasia, Focal 1 [1.0]
Pars Nervosa, Infiltration Cellular, Focal,
Mixed Cell 1 [2.0]
Thyroid Gland (48) (46) (43) (50)
Cyst 1
C-Cell, Hyperplasia 41 [1.7] 43 [1.7] 38 [1.5] 34 [1.7]
Follicle, Cyst 1 1
Follicle, Mineralization, Focal 48 [1.0] 45 [1.0] 43 [1.9] 49 [2.7]
Follicular Cell, Atrophy, Focal 1 [1.0]
Follicular Cell, Hyperplasia 17 [1.1] 37 [1.1] 43 [1.8]
Follicular Cell, Hyperplasia, Cystic, Focal 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (7) (2) (6) (4)
Mediastinum, Hemorrhage 1 [3.0]
Thoracic, Hemorrhage 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atrophy 1 [3.0] 1 [2.0]
Granuloma Sperm 1 [2.0] 1 [4.0] 1 [2.0]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Preputial Gland (50) (50) (50) (50)
Cyst 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Degeneration, Cystic 2 [2.5]
Hyperplasia 1 [2.0]
Hyperplasia, Cystic 2 [3.0] 2 [3.0] 1 [4.0]
Hyperplasia, Focal 1 [2.0]
Inflammation, Chronic 4 [2.0] 10 [1.6] 10 [1.7] 11 [2.0]
Inflammation, Chronic, Focal 1 [1.0]
Inflammation, Suppurative 1 [3.0] 1 [3.0] 2 [3.5]
Prostate (50) (50) (50) (50)
Atrophy 1 [3.0]
Hyperplasia, Focal 1 [1.0]
Inflammation, Chronic 15 [1.8] 10 [1.9] 17 [1.6] 19 [1.5]
Epithelium, Degeneration, Focal, Mucoid 1 [2.0]
Epithelium, Hyperplasia, Focal 4 [1.3] 2 [1.5] 5 [1.2]
Testes (50) (50) (50) (50)
Atrophy 5 [3.2] 4 [3.8] 13 [3.1] 13 [3.2]
Mineralization, Focal 1 [1.0]
Bilateral, Atrophy 2 [3.5] 3 [3.3] 2 [3.0]
Bilateral, Interstitial Cell, Hyperplasia,
Focal 2 [1.5]
Germinal Epithelium, Atrophy 2 [2.5] 3 [3.3] 1 [3.0] 1 [3.0]
Interstitial Cell, Hyperplasia 2 [1.5] 1 [1.0] 1 [2.0]
Interstitial Cell, Hyperplasia, Focal 1 [1.0] 4 [1.5] 4 [1.5] 9 [1.6]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (47) (50)
Fibrosis 1 [3.0]
Hyperplasia 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [3.0] 1 [2.0]
Myeloid Cell, Hyperplasia 1 [3.0] 5 [3.0]
Lymph Node (39) (49) (42) (38)
Hemorrhage 1 [2.0]
Hyperplasia, Lymphoid 1 [3.0]
Mediastinal, Angiectasis 1 [3.0]
Mediastinal, Congestion 1 [4.0]
Mediastinal, Ectasia 1 [3.0] 3 [3.0] 1 [3.0]
Mediastinal, Hemorrhage 1 [3.0] 1 [3.0] 5 [3.0] 1 [3.0]
Mediastinal, Hyperplasia, Histiocytic 2 [2.5] 1 [3.0] 4 [2.8]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [1.0] 1 [3.0] 1 [3.0]
Mediastinal, Pigmentation 1 [3.0] 1 [3.0]
Pancreatic, Angiectasis 1 [3.0] 1 [3.0]
Pancreatic, Ectasia 1 [3.0] 3 [3.0] 3 [2.7] 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Hemorrhage 1 [3.0] 1 [2.0] 4 [2.8]
Pancreatic, Hyperplasia, Focal, Histiocytic 1 [3.0]
Pancreatic, Hyperplasia, Histiocytic 13 [2.8] 12 [3.0] 15 [2.9] 19 [2.9]
Pancreatic, Hyperplasia, Lymphoid 1 [3.0] 1 [2.0]
Pancreatic, Pigmentation 1 [3.0] 1 [2.0]
Lymph Node, Mandibular (2) (1) (2) (2)
Hyperplasia, Plasma Cell 1 [4.0]
Lymph Node, Mesenteric (47) (50) (50) (50)
Ectasia 2 [2.5] 2 [3.0]
Hemorrhage 1 [3.0] 1 [3.0]
Hyperplasia, Histiocytic 1 [3.0] 2 [3.0] 1 [3.0] 4 [2.8]
Hyperplasia, Lymphoid 2 [3.0] 1 [3.0]
Spleen (49) (49) (50) (50)
Angiectasis, Focal 1 [3.0] 1 [2.0]
Congestion 1 [3.0]
Cyst 1
Fibrosis, Focal 2 [2.5] 2 [2.5] 1 [2.0]
Hematopoietic Cell Proliferation 4 [2.5] 4 [2.5] 1 [3.0] 6 [2.5]
Hemorrhage 1 [3.0]
Hemorrhage, Focal 1 [3.0]
Hyperplasia, Lymphoid 1 [2.0] 2 [2.5]
Infarct 1 [2.5] 1 [3.0]
Inflammation, Granulomatous 2 [3.0] 3 [1.7]
Necrosis, Focal 1 [4.0] 1 [2.0] 1 [3.0]
Pigmentation 1 [2.0]
Capsule, Fibrosis, Focal 1 [2.0]
Thymus (48) (48) (44) (49)
Atrophy 1 [3.0] 1 [3.0]
Cyst, Multiple 1 [4.0]
Hemorrhage 1 [3.0] 1 [2.0]
Hyperplasia, Lymphoid 2 [3.0] 1 [3.0] 1 [3.0]
Epithelial Cell, Cyst, Multiple 1 [3.0]
Epithelial Cell, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (47) (45) (42)
Dilatation 7 [2.1] 1 [2.0] 3 [2.3] 2 [2.5]
Ectasia 1 [3.0]
Hyperplasia 2 [2.0]
Hyperplasia, Cystic 1 [3.0]
Epithelium, Pigmentation 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 15
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50)
Angiectasis, Focal 1 [1.0]
Cyst Epithelial Inclusion 1 [1.0] 1 [3.0]
Fibrosis, Focal 1 [3.0]
Hemorrhage, Focal 1 [2.0] 1 [2.0]
Inflammation, Chronic, Focal 1 [2.0] 1 [2.0] 1 [2.0]
Necrosis, Focal 1 [2.0]
Pinna, Necrosis, Focal 1 [3.0]
Subcutaneous Tissue, Angiectasis, Focal 1 [2.0]
Subcutaneous Tissue, Cyst 1 [2.0]
Subcutaneous Tissue, Foreign Body 1 [3.0]
Subcutaneous Tissue, Hemorrhage, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (1) (4)
Fibrosis, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression, Focal 4 [3.0] 2 [2.5] 4 [3.0] 1 [2.0]
Hemorrhage, Focal 2 [2.5] 3 [3.3] 2 [3.0] 1 [2.0]
Necrosis, Focal 1 [3.0] 1 [3.0]
Spinal Cord (1) (1)
Hemorrhage, Focal 1 [3.0]
Mineralization, Focal 1 [2.0]
Necrosis, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1)
Glands, Hyperplasia, Focal 1 [3.0]
Lung (50) (50) (50) (50)
Congestion 1 [3.0] 1 [3.0] 1 [2.0]
Hemorrhage, Focal 1 [2.0] 1 [3.0] 1 [2.0]
Hyperplasia, Focal, Histiocytic 4 [2.3] 1 [2.0]
Hyperplasia, Histiocytic 3 [1.3] 3 [1.7] 2 [1.0] 2 [1.0]
Infiltration Cellular, Focal, Mixed Cell 1 [3.0]
Infiltration Cellular, Mixed Cell 2 [2.5] 1 [2.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 16
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Focal 1 [3.0]
Metaplasia, Focal, Osseous 2 [1.5] 1 [1.0] 2 [1.0]
Metaplasia, Osseous 2 [1.0]
Alveolar Epithelium, Hyperplasia, Focal 2 [1.0] 9 [1.6] 6 [1.7] 5 [1.8]
Alveolus, Foreign Body, Focal 1 [2.0]
Interstitium, Edema 1 [2.0] 1 [2.0]
Nose (50) (50) (50) (50)
Foreign Body 1 [2.0]
Inflammation, Suppurative 2 [2.0] 1 [2.0]
Nasolacrimal Duct, Inflammation 2 [2.0] 1 [3.0] 2 [3.0]
Nasolacrimal Duct, Inflammation, Chronic 1 [2.0]
Nasolacrimal Duct, Inflammation, Suppurative 3 [2.3]
Sinus, Foreign Body 1 [3.0]
Sinus, Inflammation, Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (46) (50)
Atrophy 1 [3.0]
Cataract 1 [3.0] 1 [2.0]
Synechia 1 [3.0]
Cornea, Inflammation, Focal 1 [2.0]
Cornea, Necrosis, Focal 1 [1.0]
Iris, Hyperplasia 1 [2.0]
Lens, Cataract 1 [2.0]
Retina, Degeneration 1 [3.0]
Retrobulbar, Inflammation, Focal 1 [2.0]
Harderian Gland (50) (50) (49) (50)
Hyperplasia, Focal 1 [1.0] 2 [1.0]
Hyperplasia, Focal, Histiocytic 1 [1.0]
Hyperplasia, Histiocytic 1 [2.0]
Inflammation, Chronic, Focal 1 [1.0] 2 [1.0] 3 [1.7]
Inflammation, Focal, Granulomatous 1 [1.0]
Epithelium, Hyperplasia, Focal 3 [1.3] 1 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (49) (50)
Accumulation, Hyaline Droplet 1 [3.0]
Atrophy, Focal 1 [2.0]
Congestion 1 [2.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 17
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/14/03
Route: DOSED FEED 2-METHYLIMIDAZOLE Time: 10:45:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cyst 2 [2.5] 2 [2.0]
Fibrosis, Focal 1 [2.0]
Infarct 1 [3.0]
Inflammation 1 [2.0]
Nephropathy 43 [1.3] 43 [1.3] 41 [1.2] 46 [1.2]
Pelvis, Inflammation, Chronic 1 [3.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [3.0]
Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0] 1 [1.0] 3 [3.0] 2 [3.0]
Renal Tubule, Necrosis, Focal 1 [2.0]
Renal Tubule, Pigmentation 5 [2.8] 3 [2.0] 2 [2.5] 3 [2.3]
Urinary Bladder (50) (50) (49) (50)
Hemorrhage 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 18
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