National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3163

TDMS Study 92012-06 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                            2-METHYLIMIDAZOLE                                            DATE: 02/24/03  
EXPERIMENT: 92012 TEST: 06                                                                                        TIME: 14:00:58    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C92012B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      2-METHYLIMIDAZOLE                                           DATE: 02/24/03    
EXPERIMENT: 92012 TEST: 06                                                                                        TIME: 14:21:33    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  92012B      
CONT: N01-ES-85420                                                                                                CAS: 693-98-1     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                          
==================================================================================================================================  
            0PPM                      625 PPM                            1250 PPM                           2500 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     4.5    23.1       4.8     23.0    1.07      129      4.7     23.0    1.04      255      4.8     23.2    1.07      515       
  8     3.9    26.6       4.1     26.1    1.05       98      3.8     24.9    0.97      192      4.0     25.2    1.03      400       
 12     4.2    31.4       4.6     30.2    1.10       96      4.4     29.7    1.05      184      4.4     29.0    1.05      376       
 16     4.4    33.4       4.3     32.9    0.98       81      4.3     32.0    0.98      168      4.2     31.2    0.95      338       
 20     4.5    35.9       4.7     34.4    1.04       85      4.5     33.3    1.00      168      4.3     32.9    0.96      325       
 24     4.4    38.0       4.5     36.7    1.02       77      4.5     35.1    1.02      159      4.5     34.1    1.02      328       
 28     4.4    40.2       4.3     39.1    0.98       69      4.5     37.9    1.02      150      4.4     37.2    1.00      298       
 32     4.7    41.9       4.6     40.7    0.98       71      4.5     39.7    0.96      143      4.6     38.3    0.98      297       
 36     4.3    43.5       4.6     42.4    1.07       68      4.8     41.4    1.12      145      4.6     40.0    1.07      288       
 40     4.3    44.5       4.4     43.7    1.02       63      4.4     42.6    1.02      129      4.5     40.8    1.05      273       
 44     4.8    44.5       4.8     43.4    1.00       69      4.7     42.4    0.98      139      4.8     40.4    1.00      297       
 48     4.8    44.7       4.6     44.2    0.96       66      4.6     43.0    0.96      134      4.8     40.7    1.00      294       
 52     4.8    44.8       4.8     44.8    1.00       67      4.7     43.8    0.98      135      4.6     41.1    0.96      281       
 56     5.3    45.5       5.3     44.3    1.00       74      5.2     43.8    0.98      148      5.0     40.8    0.94      308       
 60     5.0    45.2       4.9     44.5    0.98       69      4.9     43.8    0.98      141      4.9     39.9    0.98      310       
 64     5.1    45.9       5.1     45.0    1.00       71      5.0     43.7    0.98      145      4.9     40.1    0.96      306       
 68     5.2    46.2       5.1     45.4    0.98       70      5.2     44.4    1.00      146      5.1     40.9    0.98      312       
 72     5.1    46.8       4.9     46.1    0.96       67      5.0     44.9    0.98      139      4.8     41.3    0.94      290       
 76     4.8    46.4       4.8     45.6    1.00       66      4.7     44.0    0.98      134      4.6     41.0    0.96      279       
 80     4.3    46.6       4.3     45.5    1.00       59      4.4     43.8    1.02      124      4.1     41.0    0.95      251       
 84     5.0    45.7       5.1     45.0    1.02       71      5.3     43.1    1.06      152      4.7     40.1    0.94      295       
 88     4.7    45.7       4.6     45.5    0.98       64      4.7     42.9    1.00      138      4.6     40.3    0.98      285       
 92     4.7    44.9       5.0     45.1    1.06       69      5.0     42.2    1.06      149      4.6     40.1    0.98      285       
 96     5.3    44.7       5.2     44.6    0.98       73      5.3     42.9    1.00      153      5.2     39.1    0.98      334       
100     5.3    45.2       5.0     44.0    0.94       72      5.1     42.2    0.96      152      4.9     39.2    0.92      312       
104     4.9    42.5       5.1     42.2    1.04       76      4.8     40.8    0.98      148      4.8     37.3    0.98      322       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.2    27.0       4.5     26.4    1.07      108      4.3     25.9    1.02      210      4.4     25.8    1.05      431       
SD(D)   0.3               0.4             0.02       19      0.4             0.04       39      0.4             0.02       74       
CV(E)   6.7               7.9             2.1      17.5     10.3             4.1      18.4      8.4             2.0      17.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    41.1       4.6     40.2    1.01       72      4.6     39.1    1.00      147      4.5     37.7    1.00      302       
SD(D)   0.2               0.2             0.03        7      0.2             0.05       14      0.2             0.04       21       
CV(E)   4.6               4.2             3.5       9.9      3.3             4.7       9.5      4.3             3.9       7.1       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    5.0    45.5       5.0     44.8    1.00       69      5.0     43.3    1.00      144      4.8     40.1    0.96      299       
SD(D)   0.3               0.3             0.03        4      0.3             0.03        8      0.3             0.02       22       
CV(E)   5.9               5.1             3.2       6.4      5.2             3.2       5.8      6.0             2.1       7.2       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                          
==================================================================================================================================  
            0PPM                      625 PPM                            1250 PPM                           2500 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     2.7    20.3       3.3     20.1     1.22     102      2.9     20.0     1.07     180      2.9     20.2     1.07     364       
  8     3.6    23.1       3.7     23.6     1.03      98      3.4     23.2     0.94     182      3.6     22.9     1.00     389       
 12     3.4    25.0       3.5     24.5     1.03      89      3.5     24.2     1.03     181      3.5     24.1     1.03     365       
 16     3.3    25.8       3.3     25.9     1.00      81      3.5     25.4     1.06     170      3.4     24.7     1.03     345       
 20     3.1    27.7       3.4     27.6     1.10      77      3.2     26.8     1.03     151      3.3     26.7     1.06     308       
 24     3.6    28.7       3.4     29.2     0.94      74      3.6     28.6     1.00     159      3.7     27.9     1.03     336       
 28     3.7    30.5       4.1     31.6     1.11      81      3.9     30.7     1.05     157      4.0     29.7     1.08     333       
 32     3.6    31.0       3.7     31.9     1.03      72      3.6     31.4     1.00     143      3.6     29.6     1.00     306       
 36     3.8    30.3       3.7     32.3     0.97      73      4.0     32.0     1.05     157      3.7     29.8     0.97     314       
 40     3.8    32.9       4.0     34.0     1.05      73      3.8     34.6     1.00     136      3.8     32.1     1.00     298       
 44     4.0    32.6       4.5     33.4     1.13      84      4.3     33.5     1.08     159      4.4     31.2     1.10     352       
 48     3.6    32.4       3.7     33.4     1.03      70      3.8     33.7     1.06     141      3.9     31.7     1.08     308       
 52     4.0    32.5       3.9     34.7     0.98      70      3.8     34.6     0.95     137      3.5     32.2     0.88     275       
 56     4.3    33.6       4.5     34.5     1.05      82      4.5     34.1     1.05     164      4.4     31.5     1.02     350       
 60     4.1    34.2       4.2     35.1     1.02      75      4.2     34.5     1.02     151      4.0     31.1     0.98     321       
 64     4.0    34.3       4.0     35.3     1.00      71      4.0     34.7     1.00     144      3.9     32.0     0.98     306       
 68     4.5    34.8       4.6     35.5     1.02      81      4.6     35.2     1.02     164      4.4     32.5     0.98     339       
 72     4.2    35.0       4.3     36.9     1.02      72      4.4     35.4     1.05     157      4.8     31.8     1.14     373       
 76     3.2    34.7       3.4     35.7     1.06      59      3.3     35.3     1.03     117      3.2     31.3     1.00     257       
 80     4.1    37.0       4.1     37.5     1.00      69      4.0     36.6     0.98     135      4.0     33.0     0.98     300       
 84     4.4    38.8       4.8     36.5     1.09      82      4.9     38.1     1.11     159      4.6     34.3     1.05     338       
 88     4.2    38.5       4.2     38.4     1.00      68      4.3     38.7     1.02     137      4.1     33.8     0.98     302       
 92     3.8    38.2       3.8     38.0     1.00      63      3.9     37.9     1.03     128      3.8     33.5     1.00     281       
 96     4.3    38.2       4.4     38.2     1.02      72      4.2     38.0     0.98     138      4.1     34.4     0.95     297       
100     4.8    38.2       4.2     38.8     0.88      68      4.2     38.6     0.88     137      4.1     34.1     0.85     303       
104     4.5    37.8       5.1     38.2     1.13      84      4.6     38.0     1.02     153      4.5     33.6     1.00     336       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.3    22.8       3.5     22.8     1.09      96      3.3     22.5     1.02     181      3.3     22.4     1.03     373       
SD(D)   0.5               0.2              0.11       7      0.3              0.07       1      0.3              0.04      14       
CV(E)  14.2               5.6             10.2      6.8     10.0              6.5      0.7     10.3              3.6      3.8       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.6    30.5       3.8     31.4     1.03      75      3.7     31.1     1.03     151      3.7     29.6     1.02     317       
SD(D)   0.3               0.3              0.06       5      0.3              0.04      11      0.3              0.07      24       
CV(E)   7.8               9.2              6.0      6.5      7.7              3.8      7.5      8.3              6.5      7.5       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.2    36.4       4.3     36.8     1.02      73      4.2     36.5     1.01     145      4.1     32.8     0.99     316       
SD(D)   0.4               0.4              0.06       8      0.4              0.05      14      0.4              0.06      31       
CV(E)   9.4              10.3              5.8     10.7      9.5              5.3     10.0      9.8              6.4      9.9       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                   
                                CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
            0PPM                   625 PPM                  1250 PPM                 2500 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               21.0  60                 21.0  60                 21.1  60                 20.8  60                               
  1               21.0  60                 21.0  60                 21.1  60                 20.8  60                               
  3   5.2   876                                                                                                                     
  4   4.5  9123   23.1  59     4.8  9870   23.0  60     4.7  8970   23.0  53     4.8  9131   23.2  56                               
  8   3.9  9840   26.6  59     4.1  9758   26.1  59     3.8  9012   24.9  55     4.0  9124   25.2  56                               
 12   4.2 10020   31.4  59     4.6 10017   30.2  59     4.4  9320   29.7  55     4.4  9390   29.0  56                               
 16   4.4  9950   33.4  59     4.3  9823   32.9  59     4.3  9137   32.0  55     4.2  9126   31.2  56                               
 20   4.5  9668   35.9  59     4.7  9813   34.4  59     4.5  9044   33.3  55     4.3  9187   32.9  56                               
 24   4.4  9956   38.0  59     4.5  9824   36.7  59     4.5  8800   35.1  55     4.5  9184   34.1  56                               
 28   4.4  8189   40.2  49     4.3  8167   39.1  49     4.5  7228   37.9  45     4.4  7536   37.2  46                               
 32   4.7  8229   41.9  49     4.6  8180   40.7  49     4.5  7497   39.7  45     4.6  7471   38.3  46                               
 36   4.3  8217   43.5  49     4.6  8186   42.4  49     4.8  6973   41.4  45     4.6  7596   40.0  46                               
 40   4.3  8085   44.5  49     4.4  8032   43.7  49     4.4  7345   42.6  45     4.5  7484   40.8  46                               
 44   4.8  8096   44.5  49     4.8  8062   43.4  49     4.7  7312   42.4  45     4.8  7447   40.4  46                               
 48   4.8  8184   44.7  49     4.6  8183   44.2  49     4.6  7478   43.0  45     4.8  7548   40.7  46                               
 52   4.8  8231   44.8  49     4.8  8219   44.8  49     4.7  7352   43.8  45     4.6  7671   41.1  46                               
 56   5.3  8126   45.5  49     5.3  8094   44.3  49     5.2  7382   43.8  45     5.0  7474   40.8  46                               
 60   5.0  8254   45.2  49     4.9  8241   44.5  49     4.9  7295   43.8  44     4.9  7442   39.9  46                               
 64   5.1  8286   45.9  49     5.1  8218   45.0  49     5.0  7349   43.7  44     4.9  7568   40.1  46                               
 68   5.2  8063   46.2  49     5.1  8023   45.4  49     5.2  7184   44.4  44     5.1  7488   40.9  46                               
 72   5.1  8084   46.8  49     4.9  8030   46.1  49     5.0  7153   44.9  44     4.8  7457   41.3  46                               
 76   4.8  8111   46.4  49     4.8  8050   45.6  49     4.7  6859   44.0  43     4.6  7332   41.0  46                               
 80   4.3  8012   46.6  49     4.3  8212   45.5  49     4.4  6953   43.8  42     4.1  7418   41.0  45                               
 84   5.0  8188   45.7  49     5.1  8072   45.0  49     5.3  6896   43.1  42     4.7  7365   40.1  45                               
 88   4.7  8151   45.7  49     4.6  8261   45.5  49     4.7  6904   42.9  42     4.6  7541   40.3  45                               
 92   4.7  8118   44.9  48     5.0  8271   45.1  49     5.0  6575   42.2  40     4.6  7571   40.1  45                               
 96   5.3  7266   44.7  46     5.2  7902   44.6  48     5.3  6225   42.9  38     5.2  6881   39.1  43                               
100   5.3  6966   45.2  44     5.0  7772   44.0  48     5.1  6302   42.2  38     4.9  6706   39.2  42                               
104   4.9  7232   42.5  43     5.1  7580   42.2  47     4.8  5927   40.8  36     4.8  6556   37.3  40                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           25.5                     25.1                     24.7                     24.6                                   
14 TO 52          41.1                     40.2                     39.1                     37.7                                   
 > 52             45.5                     44.8                     43.3                     40.1                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                 
                                CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
            0PPM                   625 PPM                  1250 PPM                 2500 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               17.4  60                 17.3  60                 17.3  60                 17.7  60                               
  1               17.4  60                 17.3  60                 17.3  60                 17.7  60                               
  3   3.8  4392                4.3  4354                4.3  4212                4.1  4174                                          
  4   2.7  5743   20.3  60     3.3  5569   20.1  59     2.9  5330   20.0  59     2.9  5808   20.2  60                               
  7   3.0  5885                3.0  5674                2.8  5654                3.1  5706                                          
  8   3.6  4002   23.1  60     3.7  3924   23.6  59     3.4  3912   23.2  59     3.6  3976   22.9  60                               
 12   3.4 10153   25.0  60     3.5 10013   24.5  59     3.5  9980   24.2  59     3.5 10115   24.1  60                               
 16   3.3 10044   25.8  60     3.3  9750   25.9  59     3.5  9724   25.4  59     3.4  9857   24.7  60                               
 20   3.1  9893   27.7  60     3.4  9683   27.6  59     3.2  9421   26.8  58     3.3  9710   26.7  60                               
 24   3.6 10023   28.7  60     3.4  9744   29.2  59     3.6  9538   28.6  58     3.7  9736   27.9  60                               
 28   3.7  8259   30.5  50     4.1  8057   31.6  49     3.9  7697   30.7  48     4.0  8077   29.7  49                               
 32   3.6  8527   31.0  50     3.7  8296   31.9  49     3.6  8101   31.4  48     3.6  8425   29.6  50                               
 36   3.8  8563   30.3  50     3.7  8275   32.3  49     4.0  8021   32.0  48     3.7  8355   29.8  50                               
 40   3.8  8260   32.9  50     4.0  7979   34.0  49     3.8  7783   34.6  48     3.8  8082   32.1  50                               
 44   4.0  8249   32.6  50     4.5  8047   33.4  49     4.3  7779   33.5  48     4.4  8075   31.2  50                               
 48   3.6  8280   32.4  50     3.7  8086   33.4  49     3.8  7912   33.7  48     3.9  8120   31.7  50                               
 52   4.0  8546   32.5  50     3.9  8354   34.7  49     3.8  8173   34.6  48     3.5  8496   32.2  50                               
 56   4.3  8332   33.6  50     4.5  8074   34.5  49     4.5  7872   34.1  48     4.4  8107   31.5  50                               
 60   4.1  8357   34.2  49     4.2  8181   35.1  48     4.2  8049   34.5  48     4.0  7888   31.1  50                               
 64   4.0  8151   34.3  49     4.0  7959   35.3  48     4.0  7916   34.7  48     3.9  8097   32.0  50                               
 68   4.5  7967   34.8  49     4.6  7790   35.5  48     4.6  7768   35.2  48     4.4  7712   32.5  50                               
 72   4.2  8126   35.0  49     4.3  7941   36.9  48     4.4  7840   35.4  48     4.8  8153   31.8  50                               
 76   3.2  7865   34.7  49     3.4  7810   35.7  48     3.3  7767   35.3  48     3.2  7914   31.3  49                               
 80   4.1  7911   37.0  48     4.1  8098   37.5  48     4.0  7946   36.6  48     4.0  8143   33.0  49                               
 84   4.4  8057   38.8  48     4.8  8049   36.5  48     4.9  7779   38.1  47     4.6  8060   34.3  49                               
 88   4.2  8279   38.5  48     4.2  8040   38.4  47     4.3  8019   38.7  47     4.1  8166   33.8  48                               
 92   3.8  8088   38.2  48     3.8  7643   38.0  46     3.9  7712   37.9  46     3.8  8040   33.5  48                               
 96   4.3  7617   38.2  47     4.4  7270   38.2  45     4.2  7253   38.0  45     4.1  7551   34.4  47                               
100   4.8  6762   38.2  47     4.2  7449   38.8  44     4.2  7381   38.6  44     4.1  7696   34.1  47                               
104   4.5  7764   37.8  46     5.1  7041   38.2  43     4.6  7023   38.0  43     4.5  7485   33.6  46                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.5                     21.4                     21.2                     21.2                                   
14 TO 52          30.5                     31.4                     31.1                     29.6                                   
 > 52             36.4                     36.8                     36.5                     32.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.