https://ntp.niehs.nih.gov/go/3177

TDMS Study 92012-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                     FINAL #1; REVISION #2 MICE                                                     
               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25026 Other                                                                                  
                                       25021 Terminal Sacrifice                                                                     
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   2-METHYLIMIDAZOLE                                                                              
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Bone Marrow                            Hyperplasia                                                                                  
Epididymis                             Granuloma Sperm                                                                              
                                       Inflammation Chronic                                                                         
Heart: Perivascular                    Inflammation Chronic                                                                         
Kidney                                 Cyst                                                                                         
                                       Infarct                                                                                      
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver: Hepatocyte                      Cytoplasmic Alteration                                                                       
                                       Karyomegaly                                                                                  
Liver: Kupffer Cell                    Pigmentation                                                                                 
Lymph Node, Mandibular                 Atrophy                                                                                      
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Prostate                               Inflammation Chronic                                                                         
Spleen                                 Atrophy                                                                                      
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Testes: Germinal Epithelium            Atrophy                                                                                      
Thyroid Gland                          Degeneration Cystic                                                                          
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hyperplasia Focal                                                                            
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Hyperplasia Lymphoid                                                                         
                                       Nephropathy                                                                                  
Liver                                  Clear Cell Focus                                                                             
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
Lymph Node, Mandibular                 Hematopoietic Cell Proliferation                                                             
Lymph Node, Mesenteric                 Hematopoietic Cell Proliferation                                                             
Mesentery: Fat                         Necrosis                                                                                     
Ovary                                  Inflammation Chronic                                                                         
Salivary Glands                        Hyperplasia Lymphoid                                                                         
Spleen                                 Congestion                                                                                   
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Diverticulum                                                                                 
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
Thymus                                 Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Urinary Bladder                        Hyperplasia Lymphoid                                                                         
Uterus                                 Metaplasia                                                                                   
===============================================================                                                                     
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   8/50 (16%)   6/50 (12%)  |7/50 (14%)   5/49 (10%)   4/49 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/47.43      6/48.86      8/41.44      6/45.45     |7/48.25      5/46.83      4/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         12.3%        19.3%        13.2%       |14.5%        10.7%        8.6%         12.3%        | 
|TERMINAL (d)       |     2/43 (5%)    5/46 (11%)   8/36 (22%)   5/40 (13%)  |7/46 (15%)   5/43 (12%)   4/43 (9%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      657          729 (T)      21          |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114      P=0.158      P=0.023 *    P=0.115     |P=0.475N     P=0.427N     P=0.301N     P=0.517N     | 
|POLY 3             |     P=0.128      P=0.144      P=0.027 *    P=0.120     |P=0.460N     P=0.401N     P=0.282N     P=0.494N     | 
|POLY 1.5           |     P=0.130      P=0.139      P=0.029 *    P=0.120     |P=0.462N     P=0.397N     P=0.281N     P=0.495N     | 
|POLY 6             |     P=0.126      P=0.151      P=0.025 *    P=0.120     |P=0.460N     P=0.407N     P=0.285N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.146      P=0.137      P=0.023 *    P=0.156     |P=0.475N     P=0.427N     P=0.301N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.160      P=0.134      P=0.046 *    P=0.134     |P=0.466N     P=0.394N     P=0.274N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.053      (e)          (e)          (e)         |P=0.424N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      4/48.59      3/41.44      1/44.45     |0/48.25      0/46.83      0/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         8.2%         7.2%         2.3%        |0.0%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    4/46 (9%)    3/36 (8%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.369      P=0.419      P=0.525N    |P=0.048 *    (e)          (e)          P=0.234      | 
|POLY 3             |     P=0.333N     P=0.349      P=0.439      P=0.523N    |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 1.5           |     P=0.332N     P=0.344      P=0.447      P=0.523N    |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 6             |     P=0.335N     P=0.357      P=0.432      P=0.522N    |P=0.047 *    (e)          (e)          P=0.239      | 
|LOGISTIC REGRESSION|     P=0.342N     P=0.369      P=0.419      P=0.525N    |(e)          (e)          (e)          P=0.234      | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.339      P=0.500      P=0.500N    |P=0.047 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.291N     (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  18/50 (36%)  10/50 (20%)  10/50 (20%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     13/47.43     18/48.59     10/41.48     10/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     27.4%        37.0%        24.1%        22.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     13/43 (30%)  18/46 (39%)  9/36 (25%)   10/40 (25%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218N     P=0.257      P=0.502N     P=0.388N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.195N     P=0.215      P=0.456N     P=0.382N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.191N     P=0.205      P=0.437N     P=0.382N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.198N     P=0.231      P=0.471N     P=0.379N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.214N     P=0.257      P=0.480N     P=0.388N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.130N     P=0.194      P=0.318N     P=0.318N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.233N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |3/50 (6%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      3/41.44      2/44.45     |3/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         7.2%         4.5%        |6.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    3/36 (8%)    2/40 (5%)   |3/46 (7%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355      P=0.524      P=0.244      P=0.475     |P=0.050N     P=0.134N     P=0.134N     P=0.125N     | 
|POLY 3             |     P=0.362      P=0.508      P=0.259      P=0.477     |P=0.045N*    P=0.124N     P=0.125N     P=0.118N     | 
|POLY 1.5           |     P=0.364      P=0.505      P=0.265      P=0.477     |P=0.046N*    P=0.123N     P=0.125N     P=0.118N     | 
|POLY 6             |     P=0.361      P=0.514      P=0.254      P=0.478     |P=0.045N*    P=0.126N     P=0.126N     P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.355      P=0.524      P=0.244      P=0.475     |P=0.050N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.048N*    P=0.125N     P=0.125N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.306      (e)          (e)          (e)         |P=0.008N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      0/44.45     |0/48.25      0/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      (e)          P=0.200      (e)         |P=0.691      (e)          P=0.487      (e)          | 
|POLY 3             |     P=0.567      (e)          P=0.209      (e)         |P=0.699      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.567      (e)          P=0.212      (e)         |P=0.698      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.568      (e)          P=0.205      (e)         |P=0.699      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      (e)         |(e)          (e)          P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.220      (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   13/49 (27%)  10/49 (20%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |9/48.27      13/46.83     10/46.63     11/48.64     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |18.6%        27.8%        21.5%        22.6%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |8/46 (17%)   13/43 (30%)  10/43 (23%)  11/45 (24%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |723          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.457      P=0.183      P=0.434      P=0.381      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.480      P=0.209      P=0.467      P=0.409      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.478      P=0.214      P=0.468      P=0.408      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.480      P=0.201      P=0.461      P=0.406      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.476      P=0.182      P=0.440      P=0.399      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.470      P=0.218      P=0.480      P=0.402      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.421      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  20/50 (40%)  42/50 (84%) |10/50 (20%)  5/49 (10%)   13/48 (27%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     4/48.07      10/48.99     20/42.09     42/46.00    |10/48.25     5/47.38      13/47.56     16/49.11     | 
|POLY-3 PERCENT (g) |     8.3%         20.4%        47.5%        91.3%       |20.7%        10.6%        27.3%        32.6%        | 
|TERMINAL (d)       |     2/43 (5%)    8/46 (17%)   18/36 (50%)  36/40 (90%) |10/46 (22%)  3/43 (7%)    10/42 (24%)  13/45 (29%)  | 
|FIRST INCIDENCE    |     611          657          531          531         |729 (T)      620          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.102      P<0.001 **   P<0.001 **  |P=0.030 *    P=0.166N     P=0.248      P=0.123      | 
|POLY 3             |     P<0.001 **   P=0.079      P<0.001 **   P<0.001 **  |P=0.028 *    P=0.138N     P=0.303      P=0.137      | 
|POLY 1.5           |     P<0.001 **   P=0.076      P<0.001 **   P<0.001 **  |P=0.027 *    P=0.139N     P=0.296      P=0.134      | 
|POLY 6             |     P<0.001 **   P=0.083      P<0.001 **   P<0.001 **  |P=0.028 *    P=0.139N     P=0.308      P=0.140      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.074      P<0.001 **   P<0.001 **  |P=0.023 *    P=0.142N     P=0.306      P=0.131      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.074      P<0.001 **   P<0.001 **  |P=0.026 *    P=0.140N     P=0.278      P=0.127      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      3/41.44      6/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.2%         13.5%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    3/36 (8%)    6/40 (15%)  |                                                    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.092      P=0.014 *   |                                                    | 
|POLY 3             |     P<0.001 **   (e)          P=0.097      P=0.012 *   |                                                    | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.099      P=0.012 *   |                                                    | 
|POLY 6             |     P<0.001 **   (e)          P=0.094      P=0.012 *   |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.092      P=0.014 *   |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.121      P=0.013 *   |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      1/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          P=0.200      P=0.486     |                                                    | 
|POLY 3             |     P=0.223      (e)          P=0.209      P=0.487     |                                                    | 
|POLY 1.5           |     P=0.223      (e)          P=0.212      P=0.487     |                                                    | 
|POLY 6             |     P=0.222      (e)          P=0.205      P=0.487     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      P=0.486     |                                                    | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    7/50 (14%)   8/50 (16%)  |                                                    | 
|POLY-3 RATE (b)    |     1/47.84      3/48.59      7/41.44      8/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         16.9%        18.0%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    7/36 (19%)   8/40 (20%)  |                                                    | 
|FIRST INCIDENCE    |     611          729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.325      P=0.018 *    P=0.014 *   |                                                    | 
|POLY 3             |     P=0.004 **   P=0.311      P=0.018 *    P=0.011 *   |                                                    | 
|POLY 1.5           |     P=0.004 **   P=0.309      P=0.019 *    P=0.012 *   |                                                    | 
|POLY 6             |     P=0.004 **   P=0.315      P=0.016 *    P=0.011 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.303      P=0.021 *    P=0.014 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.008 **   P=0.309      P=0.030 *    P=0.015 *   |                                                    | 
|ORDER RESTRICTED   |     P=0.007 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      1/41.81      1/44.45     |0/48.25      1/47.16      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         2.3%        |0.0%         2.1%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          623          729 (T)     |---          639          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.221      (e)          P=0.469      P=0.486     |P=0.615N     P=0.492      P=0.224      (e)          | 
|POLY 3             |     P=0.219      (e)          P=0.475      P=0.487     |P=0.611N     P=0.495      P=0.230      (e)          | 
|POLY 1.5           |     P=0.219      (e)          P=0.478      P=0.487     |P=0.612N     P=0.496      P=0.230      (e)          | 
|POLY 6             |     P=0.218      (e)          P=0.473      P=0.487     |P=0.612N     P=0.495      P=0.229      (e)          | 
|LOGISTIC REGRESSION|     P=0.235      (e)          P=0.523      P=0.486     |P=0.619N     P=0.497      P=0.224      (e)          | 
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.500      P=0.500     |P=0.614N     P=0.495      P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.317N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/49 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      2/41.81      2/44.45     |1/48.25      0/46.83      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         4.8%         4.5%        |2.1%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    1/36 (3%)    2/40 (5%)   |1/46 (2%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      623          729 (T)     |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.379      P=0.524      P=0.441      P=0.475     |P=0.463N     P=0.513N     P=0.476      P=0.504N     | 
|POLY 3             |     P=0.385      P=0.508      P=0.456      P=0.477     |P=0.455N     P=0.506N     P=0.488      P=0.498N     | 
|POLY 1.5           |     P=0.387      P=0.505      P=0.461      P=0.477     |P=0.457N     P=0.505N     P=0.489      P=0.499N     | 
|POLY 6             |     P=0.384      P=0.514      P=0.453      P=0.478     |P=0.454N     P=0.508N     P=0.486      P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.395      P=0.524      P=0.479      P=0.475     |P=0.463N     (e)          P=0.476      (e)          | 
|COCH-ARM / FISHERS |     P=0.423      P=0.500      P=0.500      P=0.500     |P=0.460N     P=0.505N     P=0.492      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.420      (e)          (e)          (e)         |P=0.316N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/48 (4%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.43      0/48.59      2/40.53      0/44.45     |0/48.25      3/46.83      2/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.9%         0.0%        |0.0%         6.4%         4.3%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    3/43 (7%)    2/43 (5%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.487N     P=0.438      P=0.514N    |P=0.552      P=0.110      P=0.224      P=0.496      | 
|POLY 3             |     P=0.487N     P=0.495N     P=0.445      P=0.513N    |P=0.562      P=0.114      P=0.230      P=0.502      | 
|POLY 1.5           |     P=0.485N     P=0.497N     P=0.451      P=0.513N    |P=0.561      P=0.115      P=0.230      P=0.501      | 
|POLY 6             |     P=0.489N     P=0.492N     P=0.441      P=0.513N    |P=0.561      P=0.112      P=0.229      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.491N     (e)          P=0.438      (e)         |(e)          P=0.110      P=0.224      P=0.496      | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.500N     P=0.485      P=0.500N    |P=0.557      P=0.117      P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.322N     (e)          (e)          (e)         |P=0.179      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    0/48 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.43      4/48.59      0/40.53      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         8.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/43 (7%)    4/46 (9%)    0/36 (0%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.537      P=0.154N     P=0.533N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.295N     P=0.513      P=0.149N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.292N     P=0.507      P=0.146N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.297N     P=0.522      P=0.152N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.309N     P=0.537      (e)          P=0.533N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.266N     P=0.500      P=0.129N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.215N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/47.57      0/48.59      0/41.44      1/44.45     |0/48.25      0/46.83      0/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     694          ---          ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.573      P=0.483N     P=0.529N     P=0.747     |P=0.048 *    (e)          (e)          P=0.234      | 
|POLY 3             |     P=0.578      P=0.496N     P=0.527N     P=0.745     |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 1.5           |     P=0.580      P=0.498N     P=0.524N     P=0.746     |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 6             |     P=0.575      P=0.493N     P=0.531N     P=0.745     |P=0.047 *    (e)          (e)          P=0.239      | 
|LOGISTIC REGRESSION|     P=0.581      P=0.502N     P=0.512N     P=0.753     |(e)          (e)          (e)          P=0.234      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.047 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.384      (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Perivascular                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.66      0/48.59      0/41.44      0/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     668          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.057N     P=0.113N     P=0.157N     P=0.136N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.049N*    P=0.116N     P=0.146N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.048N*    P=0.117N     P=0.142N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.050N     P=0.113N     P=0.150N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.051N     P=0.121N     P=0.136N     P=0.127N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.121N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.010N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/49 (2%)    1/47 (2%)    1/50 (2%)   |2/50 (4%)    0/48 (0%)    2/48 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.72      1/47.60      1/41.44      1/44.45     |2/48.25      0/46.26      2/45.67      2/48.88      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         2.4%         2.3%        |4.2%         0.0%         4.4%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    1/46 (2%)    1/36 (3%)    1/40 (3%)   |2/46 (4%)    0/43 (0%)    2/43 (5%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          729 (T)      664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.448N     P=0.476N     P=0.562N     P=0.525N    |P=0.445      P=0.253N     P=0.670      P=0.689      | 
|POLY 3             |     P=0.428N     P=0.494N     P=0.542N     P=0.517N    |P=0.454      P=0.247N     P=0.674      P=0.689N     | 
|POLY 1.5           |     P=0.425N     P=0.496N     P=0.535N     P=0.516N    |P=0.452      P=0.247N     P=0.674      P=0.690N     | 
|POLY 6             |     P=0.432N     P=0.489N     P=0.548N     P=0.518N    |P=0.456      P=0.248N     P=0.672      P=0.688N     | 
|LOGISTIC REGRESSION|     P=0.448N     P=0.476N     P=0.562N     P=0.525N    |P=0.449      (e)          P=0.670      P=0.691      | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.516N     P=0.492N    |P=0.448      P=0.258N     P=0.676      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.440N     (e)          (e)          (e)         |P=0.434      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    1/48 (2%)    0/48 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      0/41.44      1/44.45     |1/48.27      1/45.83      0/45.67      1/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         0.0%         2.3%        |2.1%         2.2%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    1/42 (2%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |723          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.509      P=0.253      (e)          P=0.486     |P=0.614N     P=0.740      P=0.518N     P=0.755      | 
|POLY 3             |     P=0.513      P=0.243      (e)          P=0.487     |P=0.612N     P=0.749      P=0.511N     P=0.759N     | 
|POLY 1.5           |     P=0.513      P=0.240      (e)          P=0.487     |P=0.612N     P=0.750      P=0.511N     P=0.759N     | 
|POLY 6             |     P=0.513      P=0.247      (e)          P=0.487     |P=0.612N     P=0.747      P=0.512N     P=0.759N     | 
|LOGISTIC REGRESSION|     (e)          P=0.253      (e)          P=0.486     |P=0.610N     P=0.749      P=0.511N     P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.538      P=0.247      (e)          P=0.500     |P=0.613N     P=0.742      P=0.510N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.314      (e)          (e)          (e)         |P=0.528N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  12/50 (24%)  19/50 (38%) |1/50 (2%)    2/49 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     13/47.43     11/48.59     12/41.44     19/44.45    |1/48.25      2/47.16      1/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     27.4%        22.6%        29.0%        42.7%       |2.1%         4.2%         2.1%         2.1%         | 
|TERMINAL (d)       |     13/43 (30%)  11/46 (24%)  12/36 (33%)  19/40 (48%) |1/46 (2%)    1/43 (2%)    1/43 (2%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.334N     P=0.479      P=0.084     |P=0.531N     P=0.479      P=0.747      P=0.757      | 
|POLY 3             |     P=0.036 *    P=0.381N     P=0.529      P=0.091     |P=0.527N     P=0.492      P=0.753      P=0.759N     | 
|POLY 1.5           |     P=0.038 *    P=0.393N     P=0.550      P=0.093     |P=0.527N     P=0.493      P=0.753      P=0.759N     | 
|POLY 6             |     P=0.033 *    P=0.363N     P=0.511      P=0.091     |P=0.528N     P=0.491      P=0.752      P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.027 *    P=0.334N     P=0.479      P=0.084     |P=0.530N     P=0.495      P=0.747      P=0.757      | 
|COCH-ARM / FISHERS |     P=0.070      P=0.408N     P=0.500N     P=0.142     |P=0.529N     P=0.492      P=0.747      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.043 *    (e)          (e)          (e)         |P=0.577N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    3/50 (6%)   |8/50 (16%)   16/49 (33%)  8/49 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/47.66      3/48.59      3/41.44      3/44.45     |8/48.25      16/47.16     8/46.63      4/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         7.2%         6.8%        |16.6%        33.9%        17.2%        8.2%         | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    3/36 (8%)    3/40 (8%)   |8/46 (17%)   15/43 (35%)  8/43 (19%)   4/45 (9%)    | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |729 (T)      639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246      P=0.329      P=0.245      P=0.282     |P=0.043N*    P=0.034 *    P=0.550      P=0.188N     | 
|POLY 3             |     P=0.251      P=0.313      P=0.257      P=0.281     |P=0.035N*    P=0.041 *    P=0.578      P=0.174N     | 
|POLY 1.5           |     P=0.253      P=0.309      P=0.264      P=0.282     |P=0.036N*    P=0.042 *    P=0.579      P=0.175N     | 
|POLY 6             |     P=0.248      P=0.317      P=0.251      P=0.280     |P=0.035N*    P=0.040 *    P=0.574      P=0.175N     | 
|LOGISTIC REGRESSION|     P=0.255      P=0.306      P=0.264      P=0.286     |P=0.038N*    P=0.040 *    P=0.550      P=0.188N     | 
|COCH-ARM / FISHERS |     P=0.292      P=0.309      P=0.309      P=0.309     |P=0.040N*    P=0.044 *    P=0.590      P=0.178N     | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   6/50 (12%)   1/50 (2%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/48.43      6/48.59      6/41.44      1/44.45     |0/48.25      0/46.83      2/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     12.4%        12.4%        14.5%        2.3%        |0.0%         0.0%         4.3%         4.1%         | 
|TERMINAL (d)       |     5/43 (12%)   6/46 (13%)   6/36 (17%)   1/40 (3%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     24           729 (T)      729 (T)      729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070N     P=0.576N     P=0.497      P=0.073N    |P=0.088      (e)          P=0.224      P=0.234      | 
|POLY 3             |     P=0.069N     P=0.618N     P=0.508      P=0.071N    |P=0.089      (e)          P=0.230      P=0.239      | 
|POLY 1.5           |     P=0.068N     P=0.615      P=0.521      P=0.072N    |P=0.089      (e)          P=0.230      P=0.239      | 
|POLY 6             |     P=0.070N     P=0.606N     P=0.496      P=0.071N    |P=0.090      (e)          P=0.229      P=0.239      | 
|LOGISTIC REGRESSION|     P=0.051N     P=0.610      P=0.623N     P=0.040N*   |(e)          (e)          P=0.224      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.620N     P=0.620N     P=0.056N    |P=0.087      (e)          P=0.242      P=0.247      | 
|ORDER RESTRICTED   |     P=0.064N     (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/47.66      3/48.59      2/41.44      3/44.45     |0/48.25      1/46.83      0/46.63      2/49.07      | 
|POLY-3 PERCENT (g) |     10.5%        6.2%         4.8%         6.8%        |0.0%         2.1%         0.0%         4.1%         | 
|TERMINAL (d)       |     4/43 (9%)    3/46 (7%)    2/36 (6%)    3/40 (8%)   |0/46 (0%)    1/43 (2%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.356N     P=0.323N     P=0.296N     P=0.397N    |P=0.143      P=0.487      (e)          P=0.240      | 
|POLY 3             |     P=0.340N     P=0.346N     P=0.277N     P=0.396N    |P=0.144      P=0.494      (e)          P=0.241      | 
|POLY 1.5           |     P=0.335N     P=0.351N     P=0.268N     P=0.394N    |P=0.143      P=0.495      (e)          P=0.240      | 
|POLY 6             |     P=0.345N     P=0.339N     P=0.286N     P=0.397N    |P=0.144      P=0.492      (e)          P=0.242      | 
|LOGISTIC REGRESSION|     P=0.344N     P=0.349N     P=0.274N     P=0.390N    |P=0.134      P=0.487      (e)          P=0.190      | 
|COCH-ARM / FISHERS |     P=0.297N     P=0.357N     P=0.218N     P=0.357N    |P=0.141      P=0.495      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.305N     (e)          (e)          (e)         |P=0.077      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  43/50 (86%)  32/50 (64%)  31/50 (62%) |27/50 (54%)  17/49 (35%)  21/49 (43%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     34/48.03     43/48.99     32/42.15     31/44.73    |27/50.00     17/48.38     21/48.01     19/49.28     | 
|POLY-3 PERCENT (g) |     70.8%        87.8%        75.9%        69.3%       |54.0%        35.1%        43.8%        38.6%        | 
|TERMINAL (d)       |     31/43 (72%)  41/46 (89%)  29/36 (81%)  29/40 (73%) |23/46 (50%)  14/43 (33%)  16/43 (37%)  18/45 (40%)  | 
|FIRST INCIDENCE    |     668          657          611          693         |402          400          555          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331N     P=0.106      P=0.267      P=0.524N    |P=0.167N     P=0.078N     P=0.264N     P=0.107N     | 
|POLY 3             |     P=0.253N     P=0.031 *    P=0.377      P=0.529N    |P=0.149N     P=0.045N*    P=0.209N     P=0.089N     | 
|POLY 1.5           |     P=0.235N     P=0.027 *    P=0.427      P=0.519N    |P=0.145N     P=0.043N*    P=0.207N     P=0.085N     | 
|POLY 6             |     P=0.275N     P=0.040 *    P=0.332      P=0.538N    |P=0.155N     P=0.049N*    P=0.209N     P=0.096N     | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.044 *    P=0.304      P=0.493N    |P=0.146N     P=0.031N*    P=0.173N     P=0.084N     | 
|COCH-ARM / FISHERS |     P=0.088N     P=0.028 *    P=0.417N     P=0.338N    |P=0.139N     P=0.041N*    P=0.182N     P=0.080N     | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |P=0.088N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      1/48.59      2/41.44      3/44.59     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.8%         6.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    1/46 (2%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      695         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      P=0.747N     P=0.438      P=0.286     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.144      P=0.755N     P=0.453      P=0.284     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.145      P=0.757N     P=0.459      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.143      P=0.751N     P=0.448      P=0.285     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.142      P=0.747N     P=0.438      P=0.283     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165      P=0.753N     P=0.500      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.192      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    45/50 (90%) |0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.66      0/48.59      2/41.70      45/46.00    |0/48.25      2/47.25      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.8%         97.8%       |0.0%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    1/36 (3%)    39/40 (98%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     668          ---          659          531         |---          620          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.492N     P=0.439      P<0.001 **  |P=0.404N     P=0.230      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.496N     P=0.454      P<0.001 **  |P=0.404N     P=0.233      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.498N     P=0.460      P<0.001 **  |P=0.404N     P=0.233      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.493N     P=0.449      P<0.001 **  |P=0.405N     P=0.232      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.503N     P=0.487      P<0.001 **  |P=0.407N     P=0.233      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.500      P<0.001 **  |P=0.405N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.43      0/48.59      1/42.27      0/44.45     |1/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.4%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          400          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.208N     P=0.224N     P=0.551N     P=0.254N    |P=0.309N     P=0.513N     P=0.513N     P=0.504N     | 
|POLY 3             |     P=0.201N     P=0.232N     P=0.540N     P=0.252N    |P=0.307N     P=0.506N     P=0.507N     P=0.498N     | 
|POLY 1.5           |     P=0.199N     P=0.234N     P=0.536N     P=0.252N    |P=0.307N     P=0.505N     P=0.507N     P=0.499N     | 
|POLY 6             |     P=0.204N     P=0.228N     P=0.544N     P=0.252N    |P=0.306N     P=0.508N     P=0.508N     P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.163N     (e)          P=0.457N     (e)         |P=0.309N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |P=0.306N     P=0.505N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.084N     (e)          (e)          (e)         |P=0.119N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    4/49 (8%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.43      3/48.59      1/41.44      3/44.56     |0/48.25      4/47.67      1/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         6.2%         2.4%         6.7%        |0.0%         8.4%         2.1%         2.1%         | 
|TERMINAL (d)       |     2/43 (5%)    3/46 (7%)    1/36 (3%)    2/40 (5%)   |0/46 (0%)    3/43 (7%)    1/43 (2%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      701         |---          400          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.531      P=0.562N     P=0.470     |P=0.557N     P=0.058      P=0.487      P=0.496      | 
|POLY 3             |     P=0.438      P=0.511      P=0.547N     P=0.472     |P=0.551N     P=0.059      P=0.493      P=0.502      | 
|POLY 1.5           |     P=0.440      P=0.506      P=0.541N     P=0.471     |P=0.551N     P=0.059      P=0.493      P=0.501      | 
|POLY 6             |     P=0.436      P=0.519      P=0.552N     P=0.473     |P=0.553N     P=0.058      P=0.492      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.432      P=0.531      P=0.562N     P=0.471     |P=0.566N     P=0.054      P=0.487      P=0.496      | 
|COCH-ARM / FISHERS |     P=0.477      P=0.500      P=0.500N     P=0.500     |P=0.554N     P=0.056      P=0.495      P=0.500      | 
|ORDER RESTRICTED   |     P=0.457      (e)          (e)          (e)         |P=0.178      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   6/50 (12%)   8/50 (16%)  |1/50 (2%)    0/49 (0%)    1/49 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     6/47.43      9/48.59      6/41.44      8/44.45     |1/48.25      0/46.83      1/46.63      4/48.64      | 
|POLY-3 PERCENT (g) |     12.7%        18.5%        14.5%        18.0%       |2.1%         0.0%         2.1%         8.2%         | 
|TERMINAL (d)       |     6/43 (14%)   9/46 (20%)   6/36 (17%)   8/40 (20%)  |1/46 (2%)    0/43 (0%)    1/43 (2%)    4/45 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333      P=0.337      P=0.492      P=0.330     |P=0.035 *    P=0.513N     P=0.747      P=0.174      | 
|POLY 3             |     P=0.356      P=0.306      P=0.523      P=0.337     |P=0.035 *    P=0.506N     P=0.753      P=0.182      | 
|POLY 1.5           |     P=0.360      P=0.298      P=0.536      P=0.338     |P=0.035 *    P=0.505N     P=0.753      P=0.181      | 
|POLY 6             |     P=0.351      P=0.318      P=0.512      P=0.338     |P=0.035 *    P=0.508N     P=0.752      P=0.181      | 
|LOGISTIC REGRESSION|     P=0.333      P=0.337      P=0.492      P=0.330     |P=0.035 *    (e)          P=0.747      P=0.174      | 
|COCH-ARM / FISHERS |     P=0.433      P=0.288      P=0.620N     P=0.387     |P=0.035 *    P=0.505N     P=0.747      P=0.181      | 
|ORDER RESTRICTED   |     P=0.385      (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    6/50 (12%)  |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.43      3/48.59      2/41.44      6/44.73     |0/48.25      0/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         6.2%         4.8%         13.4%       |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     3/43 (7%)    3/46 (7%)    2/36 (6%)    5/40 (13%)  |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      654         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.116      P=0.631N     P=0.581N     P=0.211     |P=0.691      (e)          P=0.487      (e)          | 
|POLY 3             |     P=0.125      P=0.651N     P=0.561N     P=0.214     |P=0.699      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.127      P=0.656N     P=0.553N     P=0.213     |P=0.698      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.124      P=0.643N     P=0.568N     P=0.217     |P=0.699      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.122      P=0.631N     P=0.581N     P=0.212     |(e)          (e)          P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.151      P=0.661N     P=0.500N     P=0.243     |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |3/50 (6%)    3/49 (6%)    5/49 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.66      0/48.59      2/41.44      2/44.45     |3/48.25      3/47.41      5/47.19      3/49.10      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.8%         4.5%        |6.2%         6.3%         10.6%        6.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    2/40 (5%)   |3/46 (7%)    0/43 (0%)    4/43 (9%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     668          ---          729 (T)      729 (T)     |729 (T)      620          555          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217      P=0.492N     P=0.437      P=0.475     |P=0.537      P=0.634      P=0.326      P=0.655      | 
|POLY 3             |     P=0.220      P=0.496N     P=0.451      P=0.476     |P=0.552      P=0.654      P=0.345      P=0.654N     | 
|POLY 1.5           |     P=0.222      P=0.498N     P=0.458      P=0.477     |P=0.548      P=0.653      P=0.343      P=0.656N     | 
|POLY 6             |     P=0.218      P=0.493N     P=0.445      P=0.475     |P=0.555      P=0.654      P=0.345      P=0.652N     | 
|LOGISTIC REGRESSION|     P=0.225      P=0.503N     P=0.465      P=0.485     |P=0.530      P=0.657      P=0.350      P=0.650      | 
|COCH-ARM / FISHERS |     P=0.245      P=0.500N     P=0.500      P=0.500     |P=0.540      P=0.651      P=0.346      P=0.661N     | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.542      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      1/44.45     |0/48.25      0/46.83      1/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         2.1%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.486     |P=0.072      (e)          P=0.487      P=0.234      | 
|POLY 3             |     P=0.189      (e)          (e)          P=0.487     |P=0.073      (e)          P=0.493      P=0.239      | 
|POLY 1.5           |     P=0.190      (e)          (e)          P=0.487     |P=0.072      (e)          P=0.493      P=0.239      | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.487     |P=0.073      (e)          P=0.492      P=0.239      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.486     |(e)          (e)          P=0.487      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.071      (e)          P=0.495      P=0.247      | 
|ORDER RESTRICTED   |     P=0.109      (e)          (e)          (e)         |P=0.075      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/49 (6%)    0/49 (0%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |3/48.25      3/46.83      0/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.2%         6.4%         0.0%         12.3%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |3/46 (7%)    3/43 (7%)    0/43 (0%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.157      P=0.631      P=0.134N     P=0.232      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.648      P=0.125N     P=0.247      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.159      P=0.650      P=0.125N     P=0.246      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.644      P=0.126N     P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.157      P=0.631      (e)          P=0.232      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.160      P=0.651      P=0.125N     P=0.243      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   7/50 (14%)   7/50 (14%)  |13/50 (26%)  5/49 (10%)   12/49 (24%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     5/47.43      7/48.59      7/41.53      7/44.56     |13/48.25     5/46.83      12/46.63     10/48.64     | 
|POLY-3 PERCENT (g) |     10.5%        14.4%        16.9%        15.7%       |27.0%        10.7%        25.7%        20.6%        | 
|TERMINAL (d)       |     5/43 (12%)   7/46 (15%)   6/36 (17%)   6/40 (15%)  |13/46 (28%)  5/43 (12%)   12/43 (28%)  10/45 (22%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      706          701         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276      P=0.427      P=0.265      P=0.332     |P=0.508N     P=0.047N*    P=0.578N     P=0.338N     | 
|POLY 3             |     P=0.294      P=0.397      P=0.290      P=0.336     |P=0.483N     P=0.037N*    P=0.539N     P=0.310N     | 
|POLY 1.5           |     P=0.297      P=0.389      P=0.301      P=0.336     |P=0.487N     P=0.036N*    P=0.538N     P=0.311N     | 
|POLY 6             |     P=0.292      P=0.409      P=0.281      P=0.339     |P=0.481N     P=0.039N*    P=0.546N     P=0.311N     | 
|LOGISTIC REGRESSION|     P=0.285      P=0.427      P=0.272      P=0.337     |P=0.508N     P=0.047N*    P=0.578N     P=0.338N     | 
|COCH-ARM / FISHERS |     P=0.361      P=0.380      P=0.380      P=0.380     |P=0.495N     P=0.037N*    P=0.523N     P=0.318N     | 
|ORDER RESTRICTED   |     P=0.345      (e)          (e)          (e)         |P=0.262N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    4/50 (8%)    4/50 (8%)   |4/50 (8%)    1/49 (2%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.43      3/48.60      4/41.44      4/44.45     |4/48.25      1/46.83      3/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     8.4%         6.2%         9.7%         9.0%        |8.3%         2.1%         6.4%         0.0%         | 
|TERMINAL (d)       |     4/43 (9%)    2/46 (4%)    4/36 (11%)   4/40 (10%)  |4/46 (9%)    1/43 (2%)    3/43 (7%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      726          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.447      P=0.462N     P=0.543      P=0.604     |P=0.075N     P=0.201N     P=0.537N     P=0.066N     | 
|POLY 3             |     P=0.463      P=0.487N     P=0.567      P=0.607     |P=0.069N     P=0.188N     P=0.519N     P=0.060N     | 
|POLY 1.5           |     P=0.467      P=0.493N     P=0.577      P=0.607     |P=0.070N     P=0.187N     P=0.518N     P=0.060N     | 
|POLY 6             |     P=0.459      P=0.477N     P=0.558      P=0.608     |P=0.069N     P=0.191N     P=0.522N     P=0.060N     | 
|LOGISTIC REGRESSION|     P=0.448      P=0.455N     P=0.543      P=0.604     |P=0.075N     P=0.201N     P=0.537N     (e)          | 
|COCH-ARM / FISHERS |     P=0.518      P=0.500N     P=0.643N     P=0.643N    |P=0.072N     P=0.187N     P=0.511N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.567      (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   2/50 (4%)    6/50 (12%)  |5/50 (10%)   2/49 (4%)    3/49 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/47.66      6/48.86      2/41.44      6/44.56     |5/48.25      2/47.67      3/47.89      4/49.31      | 
|POLY-3 PERCENT (g) |     4.2%         12.3%        4.8%         13.5%       |10.4%        4.2%         6.3%         8.1%         | 
|TERMINAL (d)       |     1/43 (2%)    5/46 (11%)   2/36 (6%)    5/40 (13%)  |5/46 (11%)   1/43 (2%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     668          657          729 (T)      701         |729 (T)      400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.160      P=0.627      P=0.118     |P=0.535N     P=0.244N     P=0.389N     P=0.508N     | 
|POLY 3             |     P=0.151      P=0.142      P=0.642      P=0.113     |P=0.526N     P=0.222N     P=0.361N     P=0.486N     | 
|POLY 1.5           |     P=0.153      P=0.138      P=0.650      P=0.113     |P=0.529N     P=0.222N     P=0.363N     P=0.491N     | 
|POLY 6             |     P=0.148      P=0.148      P=0.635      P=0.112     |P=0.521N     P=0.224N     P=0.361N     P=0.482N     | 
|LOGISTIC REGRESSION|     P=0.156      P=0.135      P=0.655      P=0.116     |P=0.563      P=0.217N     P=0.298N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.189      P=0.134      P=0.691N     P=0.134     |P=0.535N     P=0.226N     P=0.369N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.086      (e)          (e)          (e)         |P=0.341N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      1/41.44      0/44.45     |0/48.25      0/46.83      2/47.00      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         2.4%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    1/36 (3%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          623          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.253      P=0.465      (e)         |P=0.594      (e)          P=0.230      (e)          | 
|POLY 3             |     P=0.487N     P=0.243      P=0.473      (e)         |P=0.602      (e)          P=0.232      (e)          | 
|POLY 1.5           |     P=0.487N     P=0.240      P=0.477      (e)         |P=0.601      (e)          P=0.231      (e)          | 
|POLY 6             |     P=0.487N     P=0.247      P=0.470      (e)         |P=0.603      (e)          P=0.231      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.253      P=0.465      (e)         |P=0.593      (e)          P=0.246      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.595      (e)          P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.317      (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    11/50 (22%)  37/50 (74%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      11/41.44     37/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         26.6%        83.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    11/36 (31%)  37/40 (93%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Karyomegaly                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    10/50 (20%)  29/50 (58%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      10/41.44     29/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         24.1%        65.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    10/36 (28%)  29/40 (73%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    19/50 (38%) |0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/48.72      1/41.44      19/45.62    |0/48.25      2/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.4%         41.7%       |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    1/36 (3%)    15/40 (38%) |0/46 (0%)    2/43 (5%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          696          729 (T)      531         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.522      P=0.465      P<0.001 **  |P=0.408N     P=0.224      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.505      P=0.473      P<0.001 **  |P=0.405N     P=0.231      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.503      P=0.477      P<0.001 **  |P=0.404N     P=0.232      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.509      P=0.470      P<0.001 **  |P=0.407N     P=0.229      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.499      P=0.465      P<0.001 **  |(e)          P=0.224      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |P=0.405N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.240N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.43      3/48.59      1/41.44      3/44.45     |2/48.27      0/46.83      0/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         2.4%         6.8%        |4.1%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    3/46 (7%)    1/36 (3%)    3/40 (8%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |723          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.269      P=0.330      P=0.722      P=0.280     |P=0.463N     P=0.257N     P=0.257N     P=0.508N     | 
|POLY 3             |     P=0.279      P=0.314      P=0.730      P=0.283     |P=0.459N     P=0.244N     P=0.245N     P=0.497N     | 
|POLY 1.5           |     P=0.281      P=0.310      P=0.734      P=0.283     |P=0.460N     P=0.243N     P=0.245N     P=0.498N     | 
|POLY 6             |     P=0.277      P=0.320      P=0.726      P=0.283     |P=0.458N     P=0.246N     P=0.246N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.269      P=0.330      P=0.722      P=0.280     |P=0.458N     P=0.246N     P=0.246N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.313      P=0.309      P=0.753N     P=0.309     |P=0.460N     P=0.253N     P=0.253N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.218      (e)          (e)          (e)         |P=0.132N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/49 (4%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |2/48.27      2/46.83      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.1%         4.3%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    2/43 (5%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |723          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.667      P=0.667      P=0.245N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.683      P=0.681      P=0.236N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.685      P=0.682      P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.679      P=0.679      P=0.236N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.163N     P=0.678      P=0.679      P=0.236N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.684      P=0.684      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   4/50 (8%)    2/50 (4%)   |4/50 (8%)    3/49 (6%)    1/49 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/47.43      8/48.72      4/41.44      2/44.72     |4/48.25      3/46.83      1/46.63      4/49.07      | 
|POLY-3 PERCENT (g) |     8.4%         16.4%        9.7%         4.5%        |8.3%         6.4%         2.1%         8.2%         | 
|TERMINAL (d)       |     4/43 (9%)    7/46 (15%)   4/36 (11%)   1/40 (3%)   |4/46 (9%)    3/43 (7%)    1/43 (2%)    3/45 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      696          729 (T)      656         |729 (T)      729 (T)      729 (T)      604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187N     P=0.216      P=0.543      P=0.371N    |P=0.576      P=0.537N     P=0.201N     P=0.633      | 
|POLY 3             |     P=0.172N     P=0.191      P=0.567      P=0.365N    |P=0.571N     P=0.516N     P=0.190N     P=0.633N     | 
|POLY 1.5           |     P=0.172N     P=0.185      P=0.577      P=0.366N    |P=0.573N     P=0.513N     P=0.189N     P=0.636N     | 
|POLY 6             |     P=0.171N     P=0.201      P=0.558      P=0.362N    |P=0.569N     P=0.521N     P=0.191N     P=0.632N     | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.199      P=0.543      P=0.363N    |P=0.575N     P=0.537N     P=0.201N     P=0.638      | 
|COCH-ARM / FISHERS |     P=0.139N     P=0.178      P=0.643N     P=0.339N    |P=0.577N     P=0.511N     P=0.187N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.151N     (e)          (e)          (e)         |P=0.420N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |9/50 (18%)   6/49 (12%)   3/49 (6%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      2/41.44      4/44.45     |9/48.25      6/46.83      3/46.63      7/48.67      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         4.8%         9.0%        |18.7%        12.8%        6.4%         14.4%        | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    2/36 (6%)    4/40 (10%)  |9/46 (20%)   6/43 (14%)   3/43 (7%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.089      P=0.524      P=0.438      P=0.159     |P=0.352N     P=0.337N     P=0.078N     P=0.411N     | 
|POLY 3             |     P=0.094      P=0.508      P=0.453      P=0.160     |P=0.337N     P=0.310N     P=0.068N     P=0.386N     | 
|POLY 1.5           |     P=0.096      P=0.505      P=0.459      P=0.160     |P=0.339N     P=0.306N     P=0.068N     P=0.387N     | 
|POLY 6             |     P=0.093      P=0.514      P=0.448      P=0.160     |P=0.336N     P=0.316N     P=0.069N     P=0.386N     | 
|LOGISTIC REGRESSION|     P=0.089      P=0.524      P=0.438      P=0.159     |P=0.338N     P=0.337N     P=0.078N     P=0.392N     | 
|COCH-ARM / FISHERS |     P=0.113      P=0.500      P=0.500      P=0.181     |P=0.343N     P=0.303N     P=0.065N     P=0.393N     | 
|ORDER RESTRICTED   |     P=0.097      (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    4/50 (8%)    2/50 (4%)   |2/50 (4%)    2/49 (4%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.43      4/48.59      4/41.44      2/44.45     |2/48.25      2/47.16      3/46.67      0/48.64      | 
|POLY-3 PERCENT (g) |     8.4%         8.2%         9.7%         4.5%        |4.2%         4.2%         6.4%         0.0%         | 
|TERMINAL (d)       |     4/43 (9%)    4/46 (9%)    4/36 (11%)   2/40 (5%)   |2/46 (4%)    1/43 (2%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      639          720          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.606N     P=0.543      P=0.371N    |P=0.204N     P=0.671      P=0.470      P=0.243N     | 
|POLY 3             |     P=0.301N     P=0.629N     P=0.567      P=0.368N    |P=0.196N     P=0.685      P=0.485      P=0.236N     | 
|POLY 1.5           |     P=0.299N     P=0.635N     P=0.577      P=0.368N    |P=0.197N     P=0.686      P=0.485      P=0.236N     | 
|POLY 6             |     P=0.304N     P=0.620N     P=0.558      P=0.367N    |P=0.196N     P=0.684      P=0.483      P=0.236N     | 
|LOGISTIC REGRESSION|     P=0.313N     P=0.606N     P=0.543      P=0.371N    |P=0.199N     P=0.690      P=0.479      (e)          | 
|COCH-ARM / FISHERS |     P=0.256N     P=0.643N     P=0.643N     P=0.339N    |P=0.199N     P=0.684      P=0.490      P=0.247N     | 
|ORDER RESTRICTED   |     P=0.356N     (e)          (e)          (e)         |P=0.150N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      1/42.27      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          400          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063      (e)          P=0.483      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.062      (e)          P=0.477      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.062      (e)          P=0.479      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.061      (e)          P=0.475      P=0.223     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.077      (e)          P=0.634      P=0.223     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      0/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      (e)          P=0.200      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.567      (e)          P=0.209      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.567      (e)          P=0.212      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.568      (e)          P=0.205      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.220      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    2/49 (4%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/47.43      3/48.59      1/41.44      3/44.45     |1/48.25      2/46.83      3/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     10.5%        6.2%         2.4%         6.8%        |2.1%         4.3%         6.4%         4.1%         | 
|TERMINAL (d)       |     5/43 (12%)   3/46 (7%)    1/36 (3%)    3/40 (8%)   |1/46 (2%)    2/43 (5%)    3/43 (7%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.320N     P=0.148N     P=0.396N    |P=0.401      P=0.476      P=0.282      P=0.492      | 
|POLY 3             |     P=0.309N     P=0.344N     P=0.136N     P=0.393N    |P=0.412      P=0.490      P=0.293      P=0.503      | 
|POLY 1.5           |     P=0.305N     P=0.350N     P=0.131N     P=0.393N    |P=0.411      P=0.491      P=0.294      P=0.502      | 
|POLY 6             |     P=0.313N     P=0.334N     P=0.140N     P=0.392N    |P=0.412      P=0.486      P=0.291      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.327N     P=0.320N     P=0.148N     P=0.396N    |P=0.401      P=0.476      P=0.282      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.273N     P=0.357N     P=0.102N     P=0.357N    |P=0.406      P=0.492      P=0.301      P=0.500      | 
|ORDER RESTRICTED   |     P=0.200N     (e)          (e)          (e)         |P=0.346      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/46 (0%)    2/45 (4%)    4/50 (8%)   |0/48 (0%)    0/48 (0%)    2/46 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/46.11      0/45.59      2/37.94      4/47.72     |0/46.25      0/46.26      2/45.36      0/47.07      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         5.3%         8.4%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |0/44 (0%)    0/43 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     611          ---          7            7           |---          ---          128          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.500N     P=0.464      P=0.173     |P=0.595      (e)          P=0.238      (e)          | 
|POLY 3             |     P=0.043 *    P=0.502N     P=0.433      P=0.190     |P=0.603      (e)          P=0.233      (e)          | 
|POLY 1.5           |     P=0.044 *    P=0.503N     P=0.440      P=0.190     |P=0.600      (e)          P=0.231      (e)          | 
|POLY 6             |     P=0.042 *    P=0.501N     P=0.426      P=0.189     |P=0.605      (e)          P=0.234      (e)          | 
|LOGISTIC REGRESSION|     P=0.170      P=0.578N     P=0.709      P=0.494     |P=0.547      (e)          P=0.273      (e)          | 
|COCH-ARM / FISHERS |     P=0.047 *    P=0.511N     P=0.476      P=0.194     |P=0.594      (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |     P=0.043 *    (e)          (e)          (e)         |P=0.243      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/46 (0%)    0/45 (0%)    0/50 (0%)   |3/48 (6%)    0/48 (0%)    0/46 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.70      0/45.59      0/36.53      0/44.45     |3/46.25      0/46.26      0/43.81      0/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |3/44 (7%)    0/43 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049N*    P=0.125N     P=0.130N     P=0.121N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.116N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.117N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.115N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.049N*    (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.048N*    P=0.121N     P=0.129N     P=0.121N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.007N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/46 (0%)    0/45 (0%)    0/50 (0%)   |2/48 (4%)    1/48 (2%)    4/46 (9%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.70      0/45.59      0/36.53      0/44.45     |2/46.25      1/46.26      4/44.18      0/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         2.2%         9.1%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |2/44 (5%)    1/43 (2%)    3/42 (7%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      623          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.280N     P=0.508N     P=0.319      P=0.238N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.272N     P=0.500N     P=0.316      P=0.233N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.275N     P=0.500N     P=0.315      P=0.235N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.270N     P=0.501N     P=0.318      P=0.233N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.282N     P=0.508N     P=0.317      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.282N     P=0.500N     P=0.318      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.147N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/48 (21%)  14/46 (30%)  9/45 (20%)   13/50 (26%) |11/48 (23%)  12/48 (25%)  10/46 (22%)  15/48 (31%)  | 
|POLY-3 RATE (b)    |     10/45.70     14/45.86     9/36.95      13/44.70    |11/46.25     12/46.64     10/43.81     15/47.10     | 
|POLY-3 PERCENT (g) |     21.9%        30.5%        24.4%        29.1%       |23.8%        25.7%        22.8%        31.8%        | 
|TERMINAL (d)       |     10/42 (24%)  13/43 (30%)  7/32 (22%)   11/40 (28%) |11/44 (25%)  11/43 (26%)  10/42 (24%)  14/44 (32%)  | 
|FIRST INCIDENCE    |     729 (T)      657          623          693         |729 (T)      620          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296      P=0.262      P=0.454      P=0.273     |P=0.219      P=0.475      P=0.549N     P=0.246      | 
|POLY 3             |     P=0.337      P=0.242      P=0.499      P=0.294     |P=0.224      P=0.509      P=0.556N     P=0.263      | 
|POLY 1.5           |     P=0.342      P=0.232      P=0.516      P=0.294     |P=0.220      P=0.506      P=0.556N     P=0.258      | 
|POLY 6             |     P=0.333      P=0.257      P=0.485      P=0.297     |P=0.227      P=0.511      P=0.559N     P=0.267      | 
|LOGISTIC REGRESSION|     P=0.328      P=0.243      P=0.471      P=0.285     |P=0.230      P=0.500      P=0.549N     P=0.263      | 
|COCH-ARM / FISHERS |     P=0.445      P=0.203      P=0.563N     P=0.358     |P=0.212      P=0.500      P=0.544N     P=0.246      | 
|ORDER RESTRICTED   |     P=0.341      (e)          (e)          (e)         |P=0.297      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/48 (17%)   6/46 (13%)   9/45 (20%)   6/50 (12%)  |24/48 (50%)  20/48 (42%)  21/46 (46%)  21/48 (44%)  | 
|POLY-3 RATE (b)    |     8/46.11      6/45.72      9/37.59      6/44.72     |24/47.17     20/46.97     21/45.74     21/47.31     | 
|POLY-3 PERCENT (g) |     17.4%        13.1%        23.9%        13.4%       |50.9%        42.6%        45.9%        44.4%        | 
|TERMINAL (d)       |     7/42 (17%)   5/43 (12%)   7/32 (22%)   5/40 (13%)  |21/44 (48%)  18/43 (42%)  18/42 (43%)  20/44 (46%)  | 
|FIRST INCIDENCE    |     611          696          512          656         |533          620          128          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.485N     P=0.367N     P=0.289      P=0.429N    |P=0.367N     P=0.319N     P=0.425N     P=0.348N     | 
|POLY 3             |     P=0.454N     P=0.393N     P=0.320      P=0.410N    |P=0.364N     P=0.275N     P=0.394N     P=0.336N     | 
|POLY 1.5           |     P=0.447N     P=0.398N     P=0.333      P=0.408N    |P=0.365N     P=0.272N     P=0.398N     P=0.336N     | 
|POLY 6             |     P=0.460N     P=0.385N     P=0.309      P=0.412N    |P=0.366N     P=0.280N     P=0.396N     P=0.341N     | 
|LOGISTIC REGRESSION|     P=0.423N     P=0.414N     P=0.354      P=0.397N    |P=0.385N     P=0.269N     P=0.395N     P=0.332N     | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.420N     P=0.441      P=0.355N    |P=0.374N     P=0.270N     P=0.415N     P=0.341N     | 
|ORDER RESTRICTED   |     P=0.451N     (e)          (e)          (e)         |P=0.412N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    1/47 (2%)    2/46 (4%)    2/48 (4%)   |0/48 (0%)    0/48 (0%)    0/47 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/44.84      1/46.72      2/41.81      2/44.86     |0/46.25      0/45.83      0/44.67      0/47.07      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         4.8%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/36 (0%)    0/40 (0%)   |0/44 (0%)    0/42 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     611          696          7            7           |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313      P=0.748N     P=0.461      P=0.480     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.330      P=0.751N     P=0.476      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.331      P=0.753N     P=0.481      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.330      P=0.748N     P=0.471      P=0.502     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.571      P=0.727      P=0.620      P=0.659     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.344      P=0.753N     P=0.492      P=0.508     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.415      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/46 (0%)    0/48 (0%)   |5/48 (10%)   3/48 (6%)    0/47 (0%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/44.43      0/46.59      0/40.71      0/43.59     |5/46.25      3/45.83      0/44.67      3/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |10.8%        6.6%         0.0%         6.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/36 (0%)    0/40 (0%)   |5/44 (11%)   3/42 (7%)    0/42 (0%)    3/44 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.382N     P=0.038N*    P=0.356N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.362N     P=0.033N*    P=0.347N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.359N     P=0.033N*    P=0.350N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.243N     P=0.366N     P=0.034N*    P=0.345N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.245N     P=0.382N     (e)          P=0.356N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.249N     P=0.357N     P=0.030N*    P=0.357N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    2/47 (4%)    2/46 (4%)    0/48 (0%)   |0/48 (0%)    1/48 (2%)    0/47 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     4/44.43      2/46.59      2/40.71      0/43.59     |0/46.25      1/46.16      0/44.67      1/47.07      | 
|POLY-3 PERCENT (g) |     9.0%         4.3%         4.9%         0.0%        |0.0%         2.2%         0.0%         2.1%         | 
|TERMINAL (d)       |     4/40 (10%)   2/44 (5%)    2/36 (6%)    0/40 (0%)   |0/44 (0%)    0/42 (0%)    0/42 (0%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          639          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.294N     P=0.386N     P=0.063N    |P=0.408      P=0.492      (e)          P=0.500      | 
|POLY 3             |     P=0.049N*    P=0.316N     P=0.378N     P=0.063N    |P=0.410      P=0.500      (e)          P=0.504      | 
|POLY 1.5           |     P=0.049N*    P=0.321N     P=0.372N     P=0.063N    |P=0.408      P=0.500      (e)          P=0.502      | 
|POLY 6             |     P=0.050N     P=0.307N     P=0.383N     P=0.062N    |P=0.410      P=0.499      (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.049N*    P=0.294N     P=0.386N     (e)         |P=0.396      P=0.500      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.043N*    P=0.339N     P=0.349N     P=0.056N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.029N*    (e)          (e)          (e)         |P=0.255      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/47 (15%)   7/47 (15%)   15/46 (33%)  10/48 (21%) |3/48 (6%)    7/48 (15%)   4/47 (9%)    6/48 (13%)   | 
|POLY-3 RATE (b)    |     7/44.70      7/46.59      15/40.71     10/43.59    |3/46.25      7/46.22      4/44.67      6/47.10      | 
|POLY-3 PERCENT (g) |     15.7%        15.0%        36.8%        22.9%       |6.5%         15.2%        9.0%         12.7%        | 
|TERMINAL (d)       |     6/40 (15%)   7/44 (16%)   15/36 (42%)  10/40 (25%) |3/44 (7%)    6/42 (14%)   4/42 (10%)   5/44 (11%)   | 
|FIRST INCIDENCE    |     657          729 (T)      729 (T)      729 (T)     |729 (T)      620          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.541N     P=0.021 *    P=0.292     |P=0.325      P=0.144      P=0.475      P=0.245      | 
|POLY 3             |     P=0.132      P=0.581N     P=0.021 *    P=0.276     |P=0.327      P=0.157      P=0.481      P=0.252      | 
|POLY 1.5           |     P=0.136      P=0.588N     P=0.024 *    P=0.277     |P=0.323      P=0.158      P=0.482      P=0.249      | 
|POLY 6             |     P=0.128      P=0.570N     P=0.019 *    P=0.276     |P=0.330      P=0.156      P=0.478      P=0.254      | 
|LOGISTIC REGRESSION|     P=0.142      P=0.583N     P=0.022 *    P=0.285     |P=0.326      P=0.157      P=0.475      P=0.252      | 
|COCH-ARM / FISHERS |     P=0.188      P=0.613N     P=0.038 *    P=0.314     |P=0.315      P=0.158      P=0.488      P=0.243      | 
|ORDER RESTRICTED   |     P=0.075      (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Bronchial                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     1/3 (33%)    0/0 (0%)     0/1 (0%)    |1/12 (8%)    0/6 (0%)     0/8 (0%)     2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       1/3.00       0/0.00       0/0.87      |1/12.00      0/5.84       0/7.18       2/9.00       | 
|POLY-3 PERCENT (g) |     0.0%         33.3%        0.0%         0.0%        |8.3%         0.0%         0.0%         22.2%        | 
|TERMINAL (d)       |     0/1 (0%)     1/3 (33%)    0/0 (0%)     0/0 (0%)    |1/12 (8%)    0/5 (0%)     0/6 (0%)     1/8 (13%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      ---          ---          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.958      P=0.718      (e)          (e)         |P=0.219      P=0.674N     P=0.638N     P=0.406      | 
|POLY 3             |     (e)          P=0.604      (e)          (e)         |P=0.218      P=0.641N     P=0.600N     P=0.397      | 
|POLY 1.5           |     (e)          P=0.591      (e)          (e)         |P=0.218      P=0.639N     P=0.592N     P=0.397      | 
|POLY 6             |     (e)          P=0.625      (e)          (e)         |P=0.217      P=0.645N     P=0.611N     P=0.397      | 
|LOGISTIC REGRESSION|     (e)          P=0.718      (e)          (e)         |P=0.217      (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.752N     P=0.600      (e)          (e)         |P=0.217      P=0.667N     P=0.600N     P=0.388      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.088      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |2/12 (17%)   1/6 (17%)    1/8 (13%)    0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |2/12.00      1/5.84       1/7.18       0/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |16.7%        17.1%        13.9%        0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |2/12 (17%)   1/5 (20%)    1/6 (17%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.222N     P=0.698      P=0.743      P=0.328N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.729      P=0.677N     P=0.298N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.197N     P=0.733      P=0.662N     P=0.298N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.723      P=0.696N     P=0.299N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.222N     P=0.698      P=0.743      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.730      P=0.656N     P=0.314N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.161N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |5/12 (42%)   3/6 (50%)    4/8 (50%)    2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |5/12.00      3/5.84       4/7.74       2/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |41.7%        51.4%        51.7%        22.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |5/12 (42%)   3/5 (60%)    3/6 (50%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.311N     P=0.440      P=0.385      P=0.390N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.545      P=0.510      P=0.327N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.554      P=0.521      P=0.326N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.249N     P=0.530      P=0.490      P=0.329N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.230N     P=0.440      P=0.653      P=0.390N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.240N     P=0.563      P=0.535      P=0.324N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.178N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |1/12 (8%)    1/6 (17%)    2/8 (25%)    2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |1/12.00      1/5.84       2/7.18       2/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.3%         17.1%        27.9%        22.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |1/12 (8%)    1/5 (20%)    2/6 (33%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.241      P=0.556      P=0.257      P=0.354      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.284      P=0.593      P=0.317      P=0.395      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.285      P=0.596      P=0.333      P=0.396      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.283      P=0.587      P=0.297      P=0.394      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.241      P=0.556      P=0.257      P=0.354      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.278      P=0.569      P=0.344      P=0.388      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |3/12 (25%)   1/6 (17%)    2/8 (25%)    0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |3/12.00      1/5.84       2/7.18       0/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |25.0%        17.1%        27.9%        0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |3/12 (25%)   1/5 (20%)    2/6 (33%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.165N     P=0.653N     P=0.572      P=0.192N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.586N     P=0.646      P=0.158N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.581N     P=0.666      P=0.157N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.595N     P=0.618      P=0.159N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.165N     P=0.653N     P=0.572      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.593N     P=0.693      P=0.165N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.082N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/49 (4%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |0/48.08      2/47.64      0/46.63      2/48.67      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.2%         0.0%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          606          ---          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.252      P=0.237      (e)          P=0.237      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.249      P=0.235      (e)          P=0.240      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.251      P=0.236      (e)          P=0.241      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.248      P=0.235      (e)          P=0.239      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.250      P=0.341      (e)          P=0.240      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.253      P=0.247      (e)          P=0.253      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/6 (67%)    1/2 (50%)    3/5 (60%)    2/2 (100%)  |2/3 (67%)    3/4 (75%)    6/6 (100%)   6/6 (100%)   | 
|POLY-3 RATE (b)    |     4/6.00       1/2.00       3/5.00       2/2.00      |2/3.00       3/4.00       6/6.00       6/6.00       | 
|POLY-3 PERCENT (g) |     66.7%        50.0%        60.0%        100.0%      |66.7%        75.0%        100.0%       100.0%       | 
|TERMINAL (d)       |     4/6 (67%)    1/2 (50%)    2/4 (50%)    2/2 (100%)  |2/3 (67%)    3/4 (75%)    5/5 (100%)   3/3 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          729 (T)     |729 (T)      729 (T)      128          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401      P=0.653N     P=0.650      P=0.500     |P=0.008 **   P=0.712      P=0.185      P=0.068      | 
|POLY 3             |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|POLY 1.5           |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|POLY 6             |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|LOGISTIC REGRESSION|     P=0.401      P=0.653N     (e)          P=0.500     |P=0.008 **   P=0.712      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.393      P=0.643N     P=0.652N     P=0.536     |P=0.127      P=0.714      P=0.333      P=0.333      | 
|ORDER RESTRICTED   |     P=0.363      (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      3/48.59      3/41.70      2/44.45     |0/48.25      1/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         7.2%         4.5%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    3/46 (7%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    1/43 (2%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.330      P=0.247      P=0.475     |P=0.568N     P=0.487      (e)          (e)          | 
|POLY 3             |     P=0.431      P=0.314      P=0.261      P=0.477     |P=0.568N     P=0.494      (e)          (e)          | 
|POLY 1.5           |     P=0.433      P=0.310      P=0.266      P=0.477     |P=0.567N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.430      P=0.320      P=0.257      P=0.478     |P=0.569N     P=0.492      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.437      P=0.330      P=0.266      P=0.475     |(e)          P=0.487      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.477      P=0.309      P=0.309      P=0.500     |P=0.566N     P=0.495      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.316      (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      4/48.59      3/41.70      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         8.2%         7.2%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    4/46 (9%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488      P=0.201      P=0.247      P=0.475     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.494      P=0.187      P=0.261      P=0.477     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.496      P=0.183      P=0.266      P=0.477     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.494      P=0.192      P=0.257      P=0.478     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.501      P=0.201      P=0.266      P=0.475     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.544      P=0.181      P=0.309      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.268      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  7/49 (14%)   8/49 (16%)   8/48 (17%)   | 
|POLY-3 RATE (b)    |                                                        |12/48.53     7/47.16      8/46.89      8/46.64      | 
|POLY-3 PERCENT (g) |                                                        |24.7%        14.8%        17.1%        17.2%        | 
|TERMINAL (d)       |                                                        |11/46 (24%)  6/43 (14%)   7/43 (16%)   8/43 (19%)   | 
|FIRST INCIDENCE    |                                                        |651          639          658          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.295N     P=0.199N     P=0.281N     P=0.278N     | 
|POLY 3             |                                                        |P=0.281N     P=0.170N     P=0.253N     P=0.257N     | 
|POLY 1.5           |                                                        |P=0.281N     P=0.168N     P=0.252N     P=0.256N     | 
|POLY 6             |                                                        |P=0.284N     P=0.175N     P=0.257N     P=0.263N     | 
|LOGISTIC REGRESSION|                                                        |P=0.278N     P=0.168N     P=0.250N     P=0.253N     | 
|COCH-ARM / FISHERS |                                                        |P=0.283N     P=0.166N     P=0.242N     P=0.259N     | 
|ORDER RESTRICTED   |                                                        |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  11/49 (22%)  15/49 (31%)  10/48 (21%)  | 
|POLY-3 RATE (b)    |                                                        |10/48.25     11/46.87     15/46.89     10/47.28     | 
|POLY-3 PERCENT (g) |                                                        |20.7%        23.5%        32.0%        21.2%        | 
|TERMINAL (d)       |                                                        |10/46 (22%)  10/43 (23%)  14/43 (33%)  9/43 (21%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      720          658          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.466      P=0.431      P=0.133      P=0.537      | 
|POLY 3             |                                                        |P=0.511      P=0.470      P=0.155      P=0.579      | 
|POLY 1.5           |                                                        |P=0.501      P=0.475      P=0.155      P=0.573      | 
|POLY 6             |                                                        |P=0.518      P=0.462      P=0.154      P=0.581      | 
|LOGISTIC REGRESSION|                                                        |P=0.488      P=0.437      P=0.148      P=0.559      | 
|COCH-ARM / FISHERS |                                                        |P=0.480      P=0.479      P=0.163      P=0.558      | 
|ORDER RESTRICTED   |                                                        |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/49 (0%)    2/49 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/48.25      0/46.83      2/46.63      0/46.64      | 
|POLY-3 PERCENT (g) |                                                        |6.2%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |                                                        |3/46 (7%)    0/43 (0%)    2/43 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.136N     P=0.134N     P=0.531N     P=0.134N     | 
|POLY 3             |                                                        |P=0.128N     P=0.124N     P=0.515N     P=0.125N     | 
|POLY 1.5           |                                                        |P=0.129N     P=0.123N     P=0.515N     P=0.125N     | 
|POLY 6             |                                                        |P=0.127N     P=0.126N     P=0.518N     P=0.125N     | 
|LOGISTIC REGRESSION|                                                        |P=0.136N     (e)          P=0.531N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.131N     P=0.125N     P=0.510N     P=0.129N     | 
|ORDER RESTRICTED   |                                                        |P=0.040N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/49 (6%)    2/50 (4%)   |1/50 (2%)    1/49 (2%)    1/48 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      0/48.59      3/41.48      2/44.45     |1/48.25      1/46.83      1/45.67      2/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         7.2%         4.5%        |2.1%         2.1%         2.2%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    2/36 (6%)    2/40 (5%)   |1/46 (2%)    1/43 (2%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          718          729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377      P=0.224N     P=0.422      P=0.669     |P=0.350      P=0.747      P=0.747      P=0.492      | 
|POLY 3             |     P=0.385      P=0.232N     P=0.439      P=0.670     |P=0.357      P=0.754      P=0.748      P=0.503      | 
|POLY 1.5           |     P=0.387      P=0.234N     P=0.447      P=0.670     |P=0.356      P=0.755      P=0.748      P=0.502      | 
|POLY 6             |     P=0.381      P=0.228N     P=0.433      P=0.671     |P=0.357      P=0.752      P=0.747      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.382      (e)          P=0.428      P=0.669     |P=0.350      P=0.747      P=0.747      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.422      P=0.247N     P=0.490      P=0.691N    |P=0.353      P=0.747      P=0.742      P=0.500      | 
|ORDER RESTRICTED   |     P=0.279      (e)          (e)          (e)         |P=0.419      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    2/48 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      1/45.07     |0/48.25      0/46.83      2/45.67      1/49.28      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.2%        |0.0%         0.0%         4.4%         2.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      531         |---          ---          729 (T)      517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226      (e)          P=0.200      P=0.487     |P=0.250      (e)          P=0.224      P=0.504      | 
|POLY 3             |     P=0.227      (e)          P=0.208      P=0.490     |P=0.258      (e)          P=0.225      P=0.504      | 
|POLY 1.5           |     P=0.225      (e)          P=0.212      P=0.489     |P=0.255      (e)          P=0.225      P=0.503      | 
|POLY 6             |     P=0.228      (e)          P=0.205      P=0.491     |P=0.260      (e)          P=0.224      P=0.505      | 
|LOGISTIC REGRESSION|     P=0.252      (e)          P=0.200      P=0.559     |P=0.233      (e)          P=0.224      P=0.268      | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.242      P=0.500     |P=0.248      (e)          P=0.237      P=0.500      | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    1/47 (2%)    2/45 (4%)    1/48 (2%)   |0/48 (0%)    1/46 (2%)    1/45 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     3/46.66      1/45.59      2/37.37      1/43.00     |0/46.25      1/44.58      1/42.89      1/47.07      | 
|POLY-3 PERCENT (g) |     6.4%         2.2%         5.4%         2.3%        |0.0%         2.2%         2.3%         2.1%         | 
|TERMINAL (d)       |     3/43 (7%)    1/43 (2%)    2/33 (6%)    1/40 (3%)   |0/44 (0%)    0/41 (0%)    1/40 (3%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.305N     P=0.620N     P=0.331N    |P=0.389      P=0.492      P=0.481      P=0.500      | 
|POLY 3             |     P=0.315N     P=0.314N     P=0.600N     P=0.335N    |P=0.395      P=0.493      P=0.485      P=0.504      | 
|POLY 1.5           |     P=0.314N     P=0.317N     P=0.593N     P=0.336N    |P=0.393      P=0.492      P=0.485      P=0.502      | 
|POLY 6             |     P=0.316N     P=0.309N     P=0.605N     P=0.333N    |P=0.396      P=0.493      P=0.485      P=0.504      | 
|LOGISTIC REGRESSION|     P=0.318N     P=0.305N     P=0.620N     P=0.331N    |P=0.381      P=0.488      P=0.481      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.287N     P=0.324N     P=0.541N     P=0.316N    |P=0.387      P=0.489      P=0.484      P=0.500      | 
|ORDER RESTRICTED   |     P=0.254N     (e)          (e)          (e)         |P=0.313      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    1/47 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/47.59      0/40.85      0/44.45     |0/48.25      3/46.83      1/44.81      1/47.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         6.4%         2.2%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/45 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    3/43 (7%)    1/43 (2%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.580      P=0.110      P=0.487      P=0.491      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.587      P=0.114      P=0.485      P=0.497      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.586      P=0.115      P=0.485      P=0.497      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.585      P=0.112      P=0.485      P=0.497      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.110      P=0.487      P=0.491      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.583      P=0.117      P=0.485      P=0.495      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/48 (2%)    2/48 (4%)    2/50 (4%)   |1/50 (2%)    3/49 (6%)    1/47 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/47.43      1/47.59      2/40.85      2/44.45     |1/48.25      3/46.83      1/44.81      0/47.64      | 
|POLY-3 PERCENT (g) |     4.2%         2.1%         4.9%         4.5%        |2.1%         6.4%         2.2%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    1/45 (2%)    2/36 (6%)    2/40 (5%)   |1/46 (2%)    3/43 (7%)    1/43 (2%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.482      P=0.484N     P=0.629      P=0.669     |P=0.209N     P=0.282      P=0.747      P=0.509N     | 
|POLY 3             |     P=0.490      P=0.499N     P=0.639      P=0.670     |P=0.205N     P=0.295      P=0.744      P=0.503N     | 
|POLY 1.5           |     P=0.492      P=0.503N     P=0.644      P=0.670     |P=0.205N     P=0.297      P=0.744      P=0.503N     | 
|POLY 6             |     P=0.487      P=0.493N     P=0.635      P=0.671     |P=0.206N     P=0.292      P=0.743      P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.482      P=0.484N     P=0.629      P=0.669     |P=0.209N     P=0.282      P=0.747      (e)          | 
|COCH-ARM / FISHERS |     P=0.536      P=0.508N     P=0.684      P=0.684N    |P=0.206N     P=0.301      P=0.737      P=0.505N     | 
|ORDER RESTRICTED   |     P=0.552      (e)          (e)          (e)         |P=0.151N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/48 (2%)    0/48 (0%)    0/50 (0%)   |1/50 (2%)    2/49 (4%)    1/47 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/47.59      0/40.85      0/44.45     |1/48.25      2/46.83      1/44.81      2/47.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.1%         4.3%         2.2%         4.2%         | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    2/43 (5%)    1/43 (2%)    2/44 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.583N     P=0.509      (e)          (e)         |P=0.433      P=0.476      P=0.747      P=0.484      | 
|POLY 3             |     P=0.575N     P=0.501      (e)          (e)         |P=0.441      P=0.490      P=0.744      P=0.496      | 
|POLY 1.5           |     P=0.575N     P=0.498      (e)          (e)         |P=0.440      P=0.491      P=0.744      P=0.495      | 
|POLY 6             |     P=0.574N     P=0.504      (e)          (e)         |P=0.440      P=0.486      P=0.743      P=0.495      | 
|LOGISTIC REGRESSION|     (e)          P=0.509      (e)          (e)         |P=0.433      P=0.476      P=0.747      P=0.484      | 
|COCH-ARM / FISHERS |     P=0.563N     P=0.495      (e)          (e)         |P=0.437      P=0.492      P=0.737      P=0.492      | 
|ORDER RESTRICTED   |     P=0.393N     (e)          (e)          (e)         |P=0.438      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  23/50 (46%)  16/50 (32%)  21/50 (42%) |                                                    | 
|POLY-3 RATE (b)    |     18/47.95     23/48.99     16/41.94     21/44.72    |                                                    | 
|POLY-3 PERCENT (g) |     37.5%        47.0%        38.2%        47.0%       |                                                    | 
|TERMINAL (d)       |     16/43 (37%)  21/46 (46%)  14/36 (39%)  20/40 (50%) |                                                    | 
|FIRST INCIDENCE    |     650          657          611          656         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261      P=0.301      P=0.501      P=0.242     |                                                    | 
|POLY 3             |     P=0.287      P=0.233      P=0.562      P=0.240     |                                                    | 
|POLY 1.5           |     P=0.300      P=0.221      P=0.583N     P=0.244     |                                                    | 
|POLY 6             |     P=0.273      P=0.252      P=0.540      P=0.236     |                                                    | 
|LOGISTIC REGRESSION|     P=0.292      P=0.224      P=0.555      P=0.247     |                                                    | 
|COCH-ARM / FISHERS |     P=0.442      P=0.208      P=0.417N     P=0.341     |                                                    | 
|ORDER RESTRICTED   |     P=0.284      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  14/50 (28%)  7/50 (14%)  |                                                    | 
|POLY-3 RATE (b)    |     14/48.07     10/48.59     14/41.48     7/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     29.1%        20.6%        33.8%        15.8%       |                                                    | 
|TERMINAL (d)       |     12/43 (28%)  10/46 (22%)  13/36 (36%)  7/40 (18%)  |                                                    | 
|FIRST INCIDENCE    |     611          729 (T)      718          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.155N     P=0.192N     P=0.372      P=0.101N    |                                                    | 
|POLY 3             |     P=0.142N     P=0.232N     P=0.405      P=0.099N    |                                                    | 
|POLY 1.5           |     P=0.136N     P=0.236N     P=0.434      P=0.096N    |                                                    | 
|POLY 6             |     P=0.149N     P=0.224N     P=0.376      P=0.101N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.139N     P=0.229N     P=0.407      P=0.092N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.241N     P=0.588N     P=0.070N    |                                                    | 
|ORDER RESTRICTED   |     P=0.100N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.43      0/48.59      0/40.44      2/45.07     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |                                                    | 
|TERMINAL (d)       |     0/42 (0%)    0/46 (0%)    0/35 (0%)    1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          531         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    (e)          (e)          P=0.228     |                                                    | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.231     |                                                    | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.229     |                                                    | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.232     |                                                    | 
|LOGISTIC REGRESSION|     P=0.050      (e)          (e)          P=0.259     |                                                    | 
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |                                                    | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |2/49.08      0/46.83      0/46.63      1/48.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.1%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |402          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.462N     P=0.252N     P=0.252N     P=0.505N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.463N     P=0.248N     P=0.249N     P=0.507N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.464N     P=0.246N     P=0.247N     P=0.507N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.251N     P=0.251N     P=0.507N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.478N     P=0.221N     P=0.149N     P=0.660N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.465N     P=0.253N     P=0.253N     P=0.508N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.138N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    5/49 (10%)   3/49 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      2/48.59      0/41.44      0/44.45     |0/48.25      5/46.83      3/46.63      2/48.07      | 
|POLY-3 PERCENT (g) |     4.2%         4.1%         0.0%         0.0%        |0.0%         10.7%        6.4%         4.2%         | 
|TERMINAL (d)       |     2/43 (5%)    2/46 (4%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    5/43 (12%)   3/43 (7%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101N     P=0.670N     P=0.278N     P=0.254N    |P=0.453      P=0.028 *    P=0.110      P=0.234      | 
|POLY 3             |     P=0.096N     P=0.685N     P=0.269N     P=0.252N    |P=0.460      P=0.028 *    P=0.113      P=0.237      | 
|POLY 1.5           |     P=0.095N     P=0.689N     P=0.264N     P=0.252N    |P=0.456      P=0.029 *    P=0.113      P=0.235      | 
|POLY 6             |     P=0.097N     P=0.679N     P=0.272N     P=0.252N    |P=0.462      P=0.027 *    P=0.112      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.101N     P=0.670N     (e)          (e)         |(e)          P=0.028 *    P=0.110      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.691N     P=0.247N     P=0.247N    |P=0.449      P=0.027 *    P=0.117      P=0.242      | 
|ORDER RESTRICTED   |     P=0.129N     (e)          (e)          (e)         |P=0.088      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/49 (8%)    3/50 (6%)   |0/50 (0%)    1/49 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/49.59      4/44.71      3/47.45     |0/48.25      1/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         9.0%         6.3%        |0.0%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    1/43 (2%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          40           7            7           |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070      P=0.504      P=0.063      P=0.120     |P=0.595N     P=0.487      P=0.487      (e)          | 
|POLY 3             |     P=0.068      P=0.509      P=0.053      P=0.119     |P=0.591N     P=0.494      P=0.493      (e)          | 
|POLY 1.5           |     P=0.069      P=0.507      P=0.055      P=0.119     |P=0.592N     P=0.495      P=0.493      (e)          | 
|POLY 6             |     P=0.068      P=0.512      P=0.052      P=0.119     |P=0.592N     P=0.492      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.521      P=0.470      (e)          P=0.588     |(e)          P=0.487      P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.072      P=0.500      P=0.056      P=0.121     |P=0.594N     P=0.495      P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.045 *    (e)          (e)          (e)         |P=0.392N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/40.71      0/44.45     |2/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |2/46 (4%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.253N     P=0.253N     P=0.243N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.244N     P=0.245N     P=0.236N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.243N     P=0.245N     P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.113N     P=0.246N     P=0.246N     P=0.236N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.119N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.029N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  21/50 (42%)  38/49 (78%)  45/50 (90%) |15/50 (30%)  20/49 (41%)  24/49 (49%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     10/48.21     21/49.00     38/43.50     45/45.89    |15/48.27     20/48.42     24/48.96     39/49.36     | 
|POLY-3 PERCENT (g) |     20.7%        42.9%        87.4%        98.1%       |31.1%        41.3%        49.0%        79.0%        | 
|TERMINAL (d)       |     7/43 (16%)   18/46 (39%)  32/36 (89%)  40/40 (100%)|14/46 (30%)  16/43 (37%)  19/43 (44%)  35/45 (78%)  | 
|FIRST INCIDENCE    |     611          657          400          531         |723          400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.153      P=0.038 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.202      P=0.054      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.195      P=0.049 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.206      P=0.059      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.181      P=0.046 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.180      P=0.042 *    P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    16/50 (32%)  33/49 (67%)  43/50 (86%) |0/50 (0%)    4/49 (8%)    11/49 (22%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     1/47.43      16/48.59     33/44.00     43/45.86    |0/48.25      4/47.67      11/47.62     34/49.32     | 
|POLY-3 PERCENT (g) |     2.1%         32.9%        75.0%        93.8%       |0.0%         8.4%         23.1%        68.9%        | 
|TERMINAL (d)       |     1/43 (2%)    16/46 (35%)  25/36 (69%)  38/40 (95%) |0/46 (0%)    3/43 (7%)    10/43 (23%)  31/45 (69%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      400          531         |---          400          128          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.058      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.059      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.059      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.058      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.054      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.056      P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    14/49 (29%)  30/50 (60%) |1/50 (2%)    3/49 (6%)    5/49 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/47.43      4/49.73      14/43.93     30/46.89    |1/48.25      3/48.05      5/48.70      4/49.36      | 
|POLY-3 PERCENT (g) |     0.0%         8.0%         31.9%        64.0%       |2.1%         6.2%         10.3%        8.1%         | 
|TERMINAL (d)       |     0/43 (0%)    1/46 (2%)    8/36 (22%)   24/40 (60%) |1/46 (2%)    1/43 (2%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          40           22           7           |729 (T)      400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.076      P<0.001 **   P<0.001 **  |P=0.167      P=0.293      P=0.102      P=0.187      | 
|POLY 3             |     P<0.001 **   P=0.067      P<0.001 **   P<0.001 **  |P=0.167      P=0.304      P=0.104      P=0.186      | 
|POLY 1.5           |     P<0.001 **   P=0.065      P<0.001 **   P<0.001 **  |P=0.163      P=0.303      P=0.102      P=0.184      | 
|POLY 6             |     P<0.001 **   P=0.070      P<0.001 **   P<0.001 **  |P=0.171      P=0.304      P=0.106      P=0.189      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.048 *    P<0.001 **   P<0.001 **  |P=0.077      P=0.282      P=0.100      P=0.149      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.059      P<0.001 **   P<0.001 **  |P=0.157      P=0.301      P=0.098      P=0.181      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.123      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/49 (4%)    0/50 (0%)   |12/50 (24%)  14/49 (29%)  13/49 (27%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     5/47.43      2/48.59      2/41.13      0/44.45     |12/48.25     14/46.83     13/46.63     16/48.64     | 
|POLY-3 PERCENT (g) |     10.5%        4.1%         4.9%         0.0%        |24.9%        29.9%        27.9%        32.9%        | 
|TERMINAL (d)       |     5/43 (12%)   2/46 (4%)    1/36 (3%)    0/40 (0%)   |12/46 (26%)  14/43 (33%)  13/43 (30%)  16/45 (36%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      611          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030N*    P=0.191N     P=0.294N     P=0.040N*   |P=0.225      P=0.332      P=0.422      P=0.227      | 
|POLY 3             |     P=0.027N*    P=0.207N     P=0.278N     P=0.037N*   |P=0.249      P=0.376      P=0.461      P=0.260      | 
|POLY 1.5           |     P=0.026N*    P=0.212N     P=0.273N     P=0.037N*   |P=0.247      P=0.381      P=0.462      P=0.259      | 
|POLY 6             |     P=0.027N*    P=0.200N     P=0.280N     P=0.036N*   |P=0.249      P=0.365      P=0.454      P=0.257      | 
|LOGISTIC REGRESSION|     P=0.027N*    P=0.191N     P=0.268N     (e)         |P=0.225      P=0.332      P=0.422      P=0.227      | 
|COCH-ARM / FISHERS |     P=0.022N*    P=0.218N     P=0.226N     P=0.028N*   |P=0.240      P=0.387      P=0.477      P=0.252      | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |P=0.302      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/47.43      2/47.60      0/41.44      0/44.45     |1/48.25      0/46.83      0/46.63      5/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |2.1%         0.0%         0.0%         10.3%        | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    5/45 (11%)   | 
|FIRST INCIDENCE    |     ---          726          ---          ---         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.255      (e)          (e)         |P=0.009 **   P=0.513N     P=0.513N     P=0.099      | 
|POLY 3             |     P=0.422N     P=0.238      (e)          (e)         |P=0.008 **   P=0.506N     P=0.507N     P=0.104      | 
|POLY 1.5           |     P=0.422N     P=0.236      (e)          (e)         |P=0.008 **   P=0.505N     P=0.507N     P=0.104      | 
|POLY 6             |     P=0.422N     P=0.242      (e)          (e)         |P=0.008 **   P=0.508N     P=0.508N     P=0.103      | 
|LOGISTIC REGRESSION|     P=0.425N     P=0.247      (e)          (e)         |P=0.009 **   (e)          (e)          P=0.099      | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.242      (e)          (e)         |P=0.009 **   P=0.505N     P=0.505N     P=0.102      | 
|ORDER RESTRICTED   |     P=0.261N     (e)          (e)          (e)         |P=0.003 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.70      1/47.59      0/41.44      0/44.45     |1/48.25      1/47.67      2/47.19      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         0.0%        |2.1%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     657          729 (T)      ---          ---         |729 (T)      400          555          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.257N     P=0.751N     P=0.537N     P=0.518N    |P=0.368N     P=0.751      P=0.484      P=0.504N     | 
|POLY 3             |     P=0.248N     P=0.760      P=0.528N     P=0.514N    |P=0.364N     P=0.758      P=0.492      P=0.498N     | 
|POLY 1.5           |     P=0.247N     P=0.758      P=0.524N     P=0.514N    |P=0.365N     P=0.758      P=0.491      P=0.499N     | 
|POLY 6             |     P=0.250N     P=0.758N     P=0.532N     P=0.515N    |P=0.364N     P=0.756      P=0.492      P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.238N     P=0.756      P=0.493N     P=0.490N    |P=0.373N     P=0.780      P=0.523      (e)          | 
|COCH-ARM / FISHERS |     P=0.235N     P=0.747      P=0.500N     P=0.500N    |P=0.366N     P=0.747      P=0.492      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.265N     (e)          (e)          (e)         |P=0.266N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.70      2/47.59      1/41.85      1/44.45     |1/48.25      0/46.83      4/47.19      1/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         4.2%         2.4%         2.3%        |2.1%         0.0%         8.5%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    2/45 (4%)    0/36 (0%)    1/40 (3%)   |1/46 (2%)    0/43 (0%)    3/43 (7%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     657          729 (T)      611          729 (T)     |729 (T)      ---          555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377N     P=0.677N     P=0.560N     P=0.527N    |P=0.444      P=0.513N     P=0.166      P=0.757      | 
|POLY 3             |     P=0.366N     P=0.693      P=0.545N     P=0.525N    |P=0.454      P=0.506N     P=0.172      P=0.759N     | 
|POLY 1.5           |     P=0.363N     P=0.690      P=0.540N     P=0.524N    |P=0.452      P=0.505N     P=0.172      P=0.759N     | 
|POLY 6             |     P=0.369N     P=0.690N     P=0.550N     P=0.525N    |P=0.455      P=0.508N     P=0.172      P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.688      P=0.496N     P=0.513N    |P=0.441      (e)          P=0.181      P=0.757      | 
|COCH-ARM / FISHERS |     P=0.335N     P=0.684      P=0.500N     P=0.500N    |P=0.446      P=0.505N     P=0.175      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.474N     (e)          (e)          (e)         |P=0.181      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    8/50 (16%)   14/50 (28%) |                                                    | 
|POLY-3 RATE (b)    |     1/47.84      4/48.72      8/41.53      14/45.34    |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         8.2%         19.3%        30.9%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    7/36 (19%)   11/40 (28%) |                                                    | 
|FIRST INCIDENCE    |     611          696          706          531         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.203      P=0.010 *    P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.185      P=0.008 **   P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.182      P=0.009 **   P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.189      P=0.008 **   P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.177      P=0.011 *    P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.181      P=0.015 *    P<0.001 **  |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/47 (15%)   5/46 (11%)   9/46 (20%)   8/47 (17%)  |5/50 (10%)   2/48 (4%)    7/48 (15%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/46.48      5/45.73      9/44.18      8/46.59     |5/49.71      2/46.22      7/47.36      3/49.35      | 
|POLY-3 PERCENT (g) |     15.1%        10.9%        20.4%        17.2%       |10.1%        4.3%         14.8%        6.1%         | 
|TERMINAL (d)       |     4/42 (10%)   3/43 (7%)    0/34 (0%)    1/38 (3%)   |2/46 (4%)    1/42 (2%)    3/42 (7%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     24           696          7            7           |402          620          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.279      P=0.362N     P=0.307      P=0.453     |P=0.447N     P=0.250N     P=0.345      P=0.363N     | 
|POLY 3             |     P=0.332      P=0.391N     P=0.350      P=0.502     |P=0.439N     P=0.248N     P=0.346      P=0.361N     | 
|POLY 1.5           |     P=0.333      P=0.393N     P=0.358      P=0.501     |P=0.441N     P=0.243N     P=0.349      P=0.360N     | 
|POLY 6             |     P=0.332      P=0.388N     P=0.346      P=0.503     |P=0.436N     P=0.253N     P=0.343      P=0.362N     | 
|LOGISTIC REGRESSION|     P=0.317N     P=0.615      P=0.265N     P=0.484N    |P=0.530N     P=0.207N     P=0.393      P=0.421N     | 
|COCH-ARM / FISHERS |     P=0.333      P=0.395N     P=0.374      P=0.500     |P=0.443N     P=0.235N     P=0.351      P=0.357N     | 
|ORDER RESTRICTED   |     P=0.357      (e)          (e)          (e)         |P=0.380N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/46 (2%)    0/46 (0%)    0/47 (0%)   |0/50 (0%)    0/48 (0%)    0/48 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/44.84      1/45.59      0/38.11      0/42.07     |0/48.25      0/45.83      0/45.63      4/48.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         8.2%         | 
|TERMINAL (d)       |     0/42 (0%)    1/43 (2%)    0/34 (0%)    0/38 (0%)   |0/46 (0%)    0/42 (0%)    0/42 (0%)    3/45 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          727          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.587N     P=0.505      (e)          (e)         |P=0.004 **   (e)          (e)          P=0.063      | 
|POLY 3             |     P=0.577N     P=0.503      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 1.5           |     P=0.576N     P=0.502      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 6             |     P=0.577N     P=0.506      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.061      | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.004 **   (e)          (e)          P=0.063      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.059      | 
|ORDER RESTRICTED   |     P=0.395N     (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  2/50 (4%)    3/50 (6%)    4/50 (8%)   |15/49 (31%)  14/48 (29%)  12/48 (25%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     10/47.66     2/48.59      3/41.44      4/44.45     |15/47.25     14/46.22     12/46.89     9/48.64      | 
|POLY-3 PERCENT (g) |     21.0%        4.1%         7.2%         9.0%        |31.8%        30.3%        25.6%        18.5%        | 
|TERMINAL (d)       |     9/43 (21%)   2/46 (4%)    3/36 (8%)    4/40 (10%)  |15/45 (33%)  13/42 (31%)  11/43 (26%)  9/45 (20%)   | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |729 (T)      620          128          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126N     P=0.012N*    P=0.074N     P=0.098N    |P=0.077N     P=0.586N     P=0.376N     P=0.118N     | 
|POLY 3             |     P=0.109N     P=0.012N*    P=0.062N     P=0.094N    |P=0.068N     P=0.528N     P=0.334N     P=0.103N     | 
|POLY 1.5           |     P=0.106N     P=0.013N*    P=0.057N     P=0.094N    |P=0.069N     P=0.527N     P=0.337N     P=0.104N     | 
|POLY 6             |     P=0.113N     P=0.011N*    P=0.066N     P=0.094N    |P=0.067N     P=0.533N     P=0.334N     P=0.103N     | 
|LOGISTIC REGRESSION|     P=0.119N     P=0.014N*    P=0.065N     P=0.093N    |P=0.073N     P=0.546N     P=0.338N     P=0.118N     | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.014N*    P=0.036N*    P=0.074N    |P=0.073N     P=0.527N     P=0.349N     P=0.109N     | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.105N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/50 (6%)    33/50 (66%) |1/49 (2%)    1/48 (2%)    1/48 (2%)    9/50 (18%)   | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      3/41.44      33/44.56    |1/47.25      1/45.83      1/45.89      9/48.67      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         7.2%         74.1%       |2.1%         2.2%         2.2%         18.5%        | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    3/36 (8%)    32/40 (80%) |1/45 (2%)    1/42 (2%)    1/43 (2%)    8/45 (18%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      701         |729 (T)      729 (T)      729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.253      P=0.092      P<0.001 **  |P<0.001 **   P=0.746      P=0.751      P=0.010 *    | 
|POLY 3             |     P<0.001 **   P=0.243      P=0.097      P<0.001 **  |P<0.001 **   P=0.754      P=0.754      P=0.009 **   | 
|POLY 1.5           |     P<0.001 **   P=0.240      P=0.099      P<0.001 **  |P<0.001 **   P=0.755      P=0.754      P=0.009 **   | 
|POLY 6             |     P<0.001 **   P=0.247      P=0.094      P<0.001 **  |P<0.001 **   P=0.752      P=0.754      P=0.009 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.253      P=0.092      P<0.001 **  |P<0.001 **   P=0.746      P=0.751      P=0.011 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.247      P=0.121      P<0.001 **  |P<0.001 **   P=0.747      P=0.747      P=0.009 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   25/50 (50%) |6/49 (12%)   3/48 (6%)    23/48 (48%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     1/47.57      0/48.59      6/42.69      25/45.00    |6/47.25      3/45.83      23/46.03     46/48.68     | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         14.1%        55.6%       |12.7%        6.6%         50.0%        94.5%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    3/36 (8%)    22/40 (55%) |6/45 (13%)   3/42 (7%)    22/43 (51%)  44/45 (98%)  | 
|FIRST INCIDENCE    |     694          ---          531          654         |729 (T)      729 (T)      693          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.483N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.277N     P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.496N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.258N     P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.498N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.255N     P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.493N     P=0.040 *    P<0.001 **  |P<0.001 **   P=0.262N     P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.502N     P=0.054      P<0.001 **  |P<0.001 **   P=0.277N     P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.056      P<0.001 **  |P<0.001 **   P=0.254N     P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |16/50 (32%)  16/49 (33%)  6/49 (12%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |16/48.25     16/46.87     6/46.63      11/48.67     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |33.2%        34.1%        12.9%        22.6%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |16/46 (35%)  15/43 (35%)  6/43 (14%)   10/45 (22%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      720          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.083N     P=0.493      P=0.022N*    P=0.202N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.070N     P=0.546      P=0.016N*    P=0.176N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.072N     P=0.552      P=0.016N*    P=0.177N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.069N     P=0.535      P=0.017N*    P=0.176N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.072N     P=0.498      P=0.022N*    P=0.182N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.077N     P=0.558      P=0.016N*    P=0.184N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.049N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    2/49 (4%)    2/49 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |3/48.25      2/46.83      2/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |                                                        |6.2%         4.3%         4.3%         12.3%        | 
|TERMINAL (d)       |                                                        |3/46 (7%)    2/43 (5%)    2/43 (5%)    6/45 (13%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.113      P=0.531N     P=0.531N     P=0.232      | 
|POLY 3             |                                                        |P=0.117      P=0.514N     P=0.515N     P=0.247      | 
|POLY 1.5           |                                                        |P=0.117      P=0.511N     P=0.515N     P=0.246      | 
|POLY 6             |                                                        |P=0.117      P=0.518N     P=0.518N     P=0.246      | 
|LOGISTIC REGRESSION|                                                        |P=0.113      P=0.531N     P=0.531N     P=0.232      | 
|COCH-ARM / FISHERS |                                                        |P=0.115      P=0.510N     P=0.510N     P=0.243      | 
|ORDER RESTRICTED   |                                                        |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   2/49 (4%)    9/49 (18%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |6/48.25      2/46.83      9/47.19      4/48.64      | 
|POLY-3 PERCENT (g) |                                                        |12.4%        4.3%         19.1%        8.2%         | 
|TERMINAL (d)       |                                                        |6/46 (13%)   2/43 (5%)    8/43 (19%)   4/45 (9%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.520N     P=0.157N     P=0.246      P=0.383N     | 
|POLY 3             |                                                        |P=0.502N     P=0.143N     P=0.272      P=0.365N     | 
|POLY 1.5           |                                                        |P=0.505N     P=0.142N     P=0.270      P=0.366N     | 
|POLY 6             |                                                        |P=0.500N     P=0.146N     P=0.272      P=0.366N     | 
|LOGISTIC REGRESSION|                                                        |P=0.508N     P=0.157N     P=0.268      P=0.383N     | 
|COCH-ARM / FISHERS |                                                        |P=0.512N     P=0.141N     P=0.274      P=0.370N     | 
|ORDER RESTRICTED   |                                                        |P=0.326      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   0/49 (0%)    5/49 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |5/48.25      0/46.83      5/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |                                                        |10.4%        0.0%         10.7%        2.1%         | 
|TERMINAL (d)       |                                                        |5/46 (11%)   0/43 (0%)    5/43 (12%)   1/45 (2%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.191N     P=0.040N*    P=0.588      P=0.109N     | 
|POLY 3             |                                                        |P=0.178N     P=0.033N*    P=0.608      P=0.100N     | 
|POLY 1.5           |                                                        |P=0.179N     P=0.033N*    P=0.609      P=0.100N     | 
|POLY 6             |                                                        |P=0.176N     P=0.034N*    P=0.605      P=0.100N     | 
|LOGISTIC REGRESSION|                                                        |P=0.191N     (e)          P=0.588      P=0.109N     | 
|COCH-ARM / FISHERS |                                                        |P=0.186N     P=0.030N*    P=0.617      P=0.102N     | 
|ORDER RESTRICTED   |                                                        |P=0.052N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |48/50 (96%)  47/49 (96%)  46/49 (94%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |                                                        |48/49.39     47/48.80     46/47.74     45/49.56     | 
|POLY-3 PERCENT (g) |                                                        |97.2%        96.3%        96.4%        90.8%        | 
|TERMINAL (d)       |                                                        |45/46 (98%)  43/43 (100%) 42/43 (98%)  42/45 (93%)  | 
|FIRST INCIDENCE    |                                                        |402          400          555          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.226N     P=0.348      P=0.489      P=0.369N     | 
|POLY 3             |                                                        |P=0.084N     P=0.634N     P=0.642N     P=0.171N     | 
|POLY 1.5           |                                                        |P=0.095N     P=0.653N     P=0.640N     P=0.186N     | 
|POLY 6             |                                                        |P=0.076N     P=0.628N     P=0.646N     P=0.164N     | 
|LOGISTIC REGRESSION|                                                        |P=0.081N     P=0.694N     P=0.585N     P=0.171N     | 
|COCH-ARM / FISHERS |                                                        |P=0.116N     P=0.684N     P=0.490N     P=0.218N     | 
|ORDER RESTRICTED   |                                                        |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).