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TDMS Study 92012-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                     FINAL #1; REVISION #2 MICE                                                     
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25026 Other                                                                                  
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   2-METHYLIMIDAZOLE                                                                              
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Bone Marrow                            Hyperplasia                                                                                  
Epididymis                             Granuloma Sperm                                                                              
                                       Inflammation Chronic                                                                         
Heart: Perivascular                    Inflammation Chronic                                                                         
Kidney                                 Cyst                                                                                         
                                       Infarct                                                                                      
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver: Hepatocyte                      Cytoplasmic Alteration                                                                       
                                       Karyomegaly                                                                                  
Liver: Kupffer Cell                    Pigmentation                                                                                 
Lymph Node, Mandibular                 Atrophy                                                                                      
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Prostate                               Inflammation Chronic                                                                         
Spleen                                 Atrophy                                                                                      
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Testes: Germinal Epithelium            Atrophy                                                                                      
Thyroid Gland                          Degeneration Cystic                                                                          
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hyperplasia Focal                                                                            
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Hyperplasia Lymphoid                                                                         
                                       Nephropathy                                                                                  
Liver                                  Clear Cell Focus                                                                             
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
Lymph Node, Mandibular                 Hematopoietic Cell Proliferation                                                             
Lymph Node, Mesenteric                 Hematopoietic Cell Proliferation                                                             
Mesentery: Fat                         Necrosis                                                                                     
Ovary                                  Inflammation Chronic                                                                         
Salivary Glands                        Hyperplasia Lymphoid                                                                         
Spleen                                 Congestion                                                                                   
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Diverticulum                                                                                 
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 08/06/04       
EXPERIMENT: 92012 TEST: 06                                                                                     TIME: 09:39:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 693-98-1        
Thymus                                 Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Urinary Bladder                        Hyperplasia Lymphoid                                                                         
Uterus                                 Metaplasia                                                                                   
===============================================================                                                                     
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   8/50 (16%)   6/50 (12%)  |7/50 (14%)   5/49 (10%)   4/49 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/47.43      6/48.86      8/41.44      6/45.45     |7/48.25      5/46.83      4/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         12.3%        19.3%        13.2%       |14.5%        10.7%        8.6%         12.3%        | 
|TERMINAL (d)       |     2/43 (5%)    5/46 (11%)   8/36 (22%)   5/40 (13%)  |7/46 (15%)   5/43 (12%)   4/43 (9%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      657          729 (T)      21          |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114      P=0.158      P=0.023 *    P=0.115     |P=0.475N     P=0.427N     P=0.301N     P=0.517N     | 
|POLY 3             |     P=0.128      P=0.144      P=0.027 *    P=0.120     |P=0.460N     P=0.401N     P=0.282N     P=0.494N     | 
|POLY 1.5           |     P=0.130      P=0.139      P=0.029 *    P=0.120     |P=0.462N     P=0.397N     P=0.281N     P=0.495N     | 
|POLY 6             |     P=0.126      P=0.151      P=0.025 *    P=0.120     |P=0.460N     P=0.407N     P=0.285N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.146      P=0.137      P=0.023 *    P=0.156     |P=0.475N     P=0.427N     P=0.301N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.160      P=0.134      P=0.046 *    P=0.134     |P=0.466N     P=0.394N     P=0.274N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.053      (e)          (e)          (e)         |P=0.424N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      4/48.59      3/41.44      1/44.45     |0/48.25      0/46.83      0/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         8.2%         7.2%         2.3%        |0.0%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    4/46 (9%)    3/36 (8%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.369      P=0.419      P=0.525N    |P=0.048 *    (e)          (e)          P=0.234      | 
|POLY 3             |     P=0.333N     P=0.349      P=0.439      P=0.523N    |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 1.5           |     P=0.332N     P=0.344      P=0.447      P=0.523N    |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 6             |     P=0.335N     P=0.357      P=0.432      P=0.522N    |P=0.047 *    (e)          (e)          P=0.239      | 
|LOGISTIC REGRESSION|     P=0.342N     P=0.369      P=0.419      P=0.525N    |(e)          (e)          (e)          P=0.234      | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.339      P=0.500      P=0.500N    |P=0.047 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.291N     (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  18/50 (36%)  10/50 (20%)  10/50 (20%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     13/47.43     18/48.59     10/41.48     10/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     27.4%        37.0%        24.1%        22.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     13/43 (30%)  18/46 (39%)  9/36 (25%)   10/40 (25%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218N     P=0.257      P=0.502N     P=0.388N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.195N     P=0.215      P=0.456N     P=0.382N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.191N     P=0.205      P=0.437N     P=0.382N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.198N     P=0.231      P=0.471N     P=0.379N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.214N     P=0.257      P=0.480N     P=0.388N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.130N     P=0.194      P=0.318N     P=0.318N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.233N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |3/50 (6%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      3/41.44      2/44.45     |3/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         7.2%         4.5%        |6.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    3/36 (8%)    2/40 (5%)   |3/46 (7%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355      P=0.524      P=0.244      P=0.475     |P=0.050N     P=0.134N     P=0.134N     P=0.125N     | 
|POLY 3             |     P=0.362      P=0.508      P=0.259      P=0.477     |P=0.045N*    P=0.124N     P=0.125N     P=0.118N     | 
|POLY 1.5           |     P=0.364      P=0.505      P=0.265      P=0.477     |P=0.046N*    P=0.123N     P=0.125N     P=0.118N     | 
|POLY 6             |     P=0.361      P=0.514      P=0.254      P=0.478     |P=0.045N*    P=0.126N     P=0.126N     P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.355      P=0.524      P=0.244      P=0.475     |P=0.050N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.048N*    P=0.125N     P=0.125N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.306      (e)          (e)          (e)         |P=0.008N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      0/44.45     |0/48.25      0/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      (e)          P=0.200      (e)         |P=0.691      (e)          P=0.487      (e)          | 
|POLY 3             |     P=0.567      (e)          P=0.209      (e)         |P=0.699      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.567      (e)          P=0.212      (e)         |P=0.698      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.568      (e)          P=0.205      (e)         |P=0.699      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      (e)         |(e)          (e)          P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.220      (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   13/49 (27%)  10/49 (20%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |9/48.27      13/46.83     10/46.63     11/48.64     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |18.6%        27.8%        21.5%        22.6%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |8/46 (17%)   13/43 (30%)  10/43 (23%)  11/45 (24%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |723          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.457      P=0.183      P=0.434      P=0.381      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.480      P=0.209      P=0.467      P=0.409      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.478      P=0.214      P=0.468      P=0.408      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.480      P=0.201      P=0.461      P=0.406      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.476      P=0.182      P=0.440      P=0.399      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.470      P=0.218      P=0.480      P=0.402      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.421      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  20/50 (40%)  42/50 (84%) |10/50 (20%)  5/49 (10%)   13/48 (27%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     4/48.07      10/48.99     20/42.09     42/46.00    |10/48.25     5/47.38      13/47.56     16/49.11     | 
|POLY-3 PERCENT (g) |     8.3%         20.4%        47.5%        91.3%       |20.7%        10.6%        27.3%        32.6%        | 
|TERMINAL (d)       |     2/43 (5%)    8/46 (17%)   18/36 (50%)  36/40 (90%) |10/46 (22%)  3/43 (7%)    10/42 (24%)  13/45 (29%)  | 
|FIRST INCIDENCE    |     611          657          531          531         |729 (T)      620          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.102      P<0.001 **   P<0.001 **  |P=0.030 *    P=0.166N     P=0.248      P=0.123      | 
|POLY 3             |     P<0.001 **   P=0.079      P<0.001 **   P<0.001 **  |P=0.028 *    P=0.138N     P=0.303      P=0.137      | 
|POLY 1.5           |     P<0.001 **   P=0.076      P<0.001 **   P<0.001 **  |P=0.027 *    P=0.139N     P=0.296      P=0.134      | 
|POLY 6             |     P<0.001 **   P=0.083      P<0.001 **   P<0.001 **  |P=0.028 *    P=0.139N     P=0.308      P=0.140      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.074      P<0.001 **   P<0.001 **  |P=0.023 *    P=0.142N     P=0.306      P=0.131      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.074      P<0.001 **   P<0.001 **  |P=0.026 *    P=0.140N     P=0.278      P=0.127      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      3/41.44      6/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.2%         13.5%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    3/36 (8%)    6/40 (15%)  |                                                    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.092      P=0.014 *   |                                                    | 
|POLY 3             |     P<0.001 **   (e)          P=0.097      P=0.012 *   |                                                    | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.099      P=0.012 *   |                                                    | 
|POLY 6             |     P<0.001 **   (e)          P=0.094      P=0.012 *   |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.092      P=0.014 *   |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.121      P=0.013 *   |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      1/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          P=0.200      P=0.486     |                                                    | 
|POLY 3             |     P=0.223      (e)          P=0.209      P=0.487     |                                                    | 
|POLY 1.5           |     P=0.223      (e)          P=0.212      P=0.487     |                                                    | 
|POLY 6             |     P=0.222      (e)          P=0.205      P=0.487     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      P=0.486     |                                                    | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    7/50 (14%)   8/50 (16%)  |                                                    | 
|POLY-3 RATE (b)    |     1/47.84      3/48.59      7/41.44      8/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         16.9%        18.0%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    7/36 (19%)   8/40 (20%)  |                                                    | 
|FIRST INCIDENCE    |     611          729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.325      P=0.018 *    P=0.014 *   |                                                    | 
|POLY 3             |     P=0.004 **   P=0.311      P=0.018 *    P=0.011 *   |                                                    | 
|POLY 1.5           |     P=0.004 **   P=0.309      P=0.019 *    P=0.012 *   |                                                    | 
|POLY 6             |     P=0.004 **   P=0.315      P=0.016 *    P=0.011 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.303      P=0.021 *    P=0.014 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.008 **   P=0.309      P=0.030 *    P=0.015 *   |                                                    | 
|ORDER RESTRICTED   |     P=0.007 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      1/41.81      1/44.45     |0/48.25      1/47.16      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         2.3%        |0.0%         2.1%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          623          729 (T)     |---          639          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.221      (e)          P=0.469      P=0.486     |P=0.615N     P=0.492      P=0.224      (e)          | 
|POLY 3             |     P=0.219      (e)          P=0.475      P=0.487     |P=0.611N     P=0.495      P=0.230      (e)          | 
|POLY 1.5           |     P=0.219      (e)          P=0.478      P=0.487     |P=0.612N     P=0.496      P=0.230      (e)          | 
|POLY 6             |     P=0.218      (e)          P=0.473      P=0.487     |P=0.612N     P=0.495      P=0.229      (e)          | 
|LOGISTIC REGRESSION|     P=0.235      (e)          P=0.523      P=0.486     |P=0.619N     P=0.497      P=0.224      (e)          | 
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.500      P=0.500     |P=0.614N     P=0.495      P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.317N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/49 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      2/41.81      2/44.45     |1/48.25      0/46.83      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         4.8%         4.5%        |2.1%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    1/36 (3%)    2/40 (5%)   |1/46 (2%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      623          729 (T)     |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.379      P=0.524      P=0.441      P=0.475     |P=0.463N     P=0.513N     P=0.476      P=0.504N     | 
|POLY 3             |     P=0.385      P=0.508      P=0.456      P=0.477     |P=0.455N     P=0.506N     P=0.488      P=0.498N     | 
|POLY 1.5           |     P=0.387      P=0.505      P=0.461      P=0.477     |P=0.457N     P=0.505N     P=0.489      P=0.499N     | 
|POLY 6             |     P=0.384      P=0.514      P=0.453      P=0.478     |P=0.454N     P=0.508N     P=0.486      P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.395      P=0.524      P=0.479      P=0.475     |P=0.463N     (e)          P=0.476      (e)          | 
|COCH-ARM / FISHERS |     P=0.423      P=0.500      P=0.500      P=0.500     |P=0.460N     P=0.505N     P=0.492      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.420      (e)          (e)          (e)         |P=0.316N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/48 (4%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.43      0/48.59      2/40.53      0/44.45     |0/48.25      3/46.83      2/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.9%         0.0%        |0.0%         6.4%         4.3%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    3/43 (7%)    2/43 (5%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.487N     P=0.438      P=0.514N    |P=0.552      P=0.110      P=0.224      P=0.496      | 
|POLY 3             |     P=0.487N     P=0.495N     P=0.445      P=0.513N    |P=0.562      P=0.114      P=0.230      P=0.502      | 
|POLY 1.5           |     P=0.485N     P=0.497N     P=0.451      P=0.513N    |P=0.561      P=0.115      P=0.230      P=0.501      | 
|POLY 6             |     P=0.489N     P=0.492N     P=0.441      P=0.513N    |P=0.561      P=0.112      P=0.229      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.491N     (e)          P=0.438      (e)         |(e)          P=0.110      P=0.224      P=0.496      | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.500N     P=0.485      P=0.500N    |P=0.557      P=0.117      P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.322N     (e)          (e)          (e)         |P=0.179      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    0/48 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.43      4/48.59      0/40.53      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         8.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/43 (7%)    4/46 (9%)    0/36 (0%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.537      P=0.154N     P=0.533N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.295N     P=0.513      P=0.149N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.292N     P=0.507      P=0.146N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.297N     P=0.522      P=0.152N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.309N     P=0.537      (e)          P=0.533N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.266N     P=0.500      P=0.129N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.215N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/47.57      0/48.59      0/41.44      1/44.45     |0/48.25      0/46.83      0/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     694          ---          ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.573      P=0.483N     P=0.529N     P=0.747     |P=0.048 *    (e)          (e)          P=0.234      | 
|POLY 3             |     P=0.578      P=0.496N     P=0.527N     P=0.745     |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 1.5           |     P=0.580      P=0.498N     P=0.524N     P=0.746     |P=0.047 *    (e)          (e)          P=0.239      | 
|POLY 6             |     P=0.575      P=0.493N     P=0.531N     P=0.745     |P=0.047 *    (e)          (e)          P=0.239      | 
|LOGISTIC REGRESSION|     P=0.581      P=0.502N     P=0.512N     P=0.753     |(e)          (e)          (e)          P=0.234      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.047 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.384      (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Perivascular                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.66      0/48.59      0/41.44      0/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     668          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.057N     P=0.113N     P=0.157N     P=0.136N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.049N*    P=0.116N     P=0.146N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.048N*    P=0.117N     P=0.142N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.050N     P=0.113N     P=0.150N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.051N     P=0.121N     P=0.136N     P=0.127N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.121N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.010N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/49 (2%)    1/47 (2%)    1/50 (2%)   |2/50 (4%)    0/48 (0%)    2/48 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.72      1/47.60      1/41.44      1/44.45     |2/48.25      0/46.26      2/45.67      2/48.88      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         2.4%         2.3%        |4.2%         0.0%         4.4%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    1/46 (2%)    1/36 (3%)    1/40 (3%)   |2/46 (4%)    0/43 (0%)    2/43 (5%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          729 (T)      664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.448N     P=0.476N     P=0.562N     P=0.525N    |P=0.445      P=0.253N     P=0.670      P=0.689      | 
|POLY 3             |     P=0.428N     P=0.494N     P=0.542N     P=0.517N    |P=0.454      P=0.247N     P=0.674      P=0.689N     | 
|POLY 1.5           |     P=0.425N     P=0.496N     P=0.535N     P=0.516N    |P=0.452      P=0.247N     P=0.674      P=0.690N     | 
|POLY 6             |     P=0.432N     P=0.489N     P=0.548N     P=0.518N    |P=0.456      P=0.248N     P=0.672      P=0.688N     | 
|LOGISTIC REGRESSION|     P=0.448N     P=0.476N     P=0.562N     P=0.525N    |P=0.449      (e)          P=0.670      P=0.691      | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.516N     P=0.492N    |P=0.448      P=0.258N     P=0.676      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.440N     (e)          (e)          (e)         |P=0.434      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    1/48 (2%)    0/48 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      0/41.44      1/44.45     |1/48.27      1/45.83      0/45.67      1/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         0.0%         2.3%        |2.1%         2.2%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    1/42 (2%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |723          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.509      P=0.253      (e)          P=0.486     |P=0.614N     P=0.740      P=0.518N     P=0.755      | 
|POLY 3             |     P=0.513      P=0.243      (e)          P=0.487     |P=0.612N     P=0.749      P=0.511N     P=0.759N     | 
|POLY 1.5           |     P=0.513      P=0.240      (e)          P=0.487     |P=0.612N     P=0.750      P=0.511N     P=0.759N     | 
|POLY 6             |     P=0.513      P=0.247      (e)          P=0.487     |P=0.612N     P=0.747      P=0.512N     P=0.759N     | 
|LOGISTIC REGRESSION|     (e)          P=0.253      (e)          P=0.486     |P=0.610N     P=0.749      P=0.511N     P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.538      P=0.247      (e)          P=0.500     |P=0.613N     P=0.742      P=0.510N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.314      (e)          (e)          (e)         |P=0.528N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  12/50 (24%)  19/50 (38%) |1/50 (2%)    2/49 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     13/47.43     11/48.59     12/41.44     19/44.45    |1/48.25      2/47.16      1/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     27.4%        22.6%        29.0%        42.7%       |2.1%         4.2%         2.1%         2.1%         | 
|TERMINAL (d)       |     13/43 (30%)  11/46 (24%)  12/36 (33%)  19/40 (48%) |1/46 (2%)    1/43 (2%)    1/43 (2%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.334N     P=0.479      P=0.084     |P=0.531N     P=0.479      P=0.747      P=0.757      | 
|POLY 3             |     P=0.036 *    P=0.381N     P=0.529      P=0.091     |P=0.527N     P=0.492      P=0.753      P=0.759N     | 
|POLY 1.5           |     P=0.038 *    P=0.393N     P=0.550      P=0.093     |P=0.527N     P=0.493      P=0.753      P=0.759N     | 
|POLY 6             |     P=0.033 *    P=0.363N     P=0.511      P=0.091     |P=0.528N     P=0.491      P=0.752      P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.027 *    P=0.334N     P=0.479      P=0.084     |P=0.530N     P=0.495      P=0.747      P=0.757      | 
|COCH-ARM / FISHERS |     P=0.070      P=0.408N     P=0.500N     P=0.142     |P=0.529N     P=0.492      P=0.747      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.043 *    (e)          (e)          (e)         |P=0.577N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    3/50 (6%)   |8/50 (16%)   16/49 (33%)  8/49 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/47.66      3/48.59      3/41.44      3/44.45     |8/48.25      16/47.16     8/46.63      4/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         7.2%         6.8%        |16.6%        33.9%        17.2%        8.2%         | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    3/36 (8%)    3/40 (8%)   |8/46 (17%)   15/43 (35%)  8/43 (19%)   4/45 (9%)    | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |729 (T)      639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246      P=0.329      P=0.245      P=0.282     |P=0.043N*    P=0.034 *    P=0.550      P=0.188N     | 
|POLY 3             |     P=0.251      P=0.313      P=0.257      P=0.281     |P=0.035N*    P=0.041 *    P=0.578      P=0.174N     | 
|POLY 1.5           |     P=0.253      P=0.309      P=0.264      P=0.282     |P=0.036N*    P=0.042 *    P=0.579      P=0.175N     | 
|POLY 6             |     P=0.248      P=0.317      P=0.251      P=0.280     |P=0.035N*    P=0.040 *    P=0.574      P=0.175N     | 
|LOGISTIC REGRESSION|     P=0.255      P=0.306      P=0.264      P=0.286     |P=0.038N*    P=0.040 *    P=0.550      P=0.188N     | 
|COCH-ARM / FISHERS |     P=0.292      P=0.309      P=0.309      P=0.309     |P=0.040N*    P=0.044 *    P=0.590      P=0.178N     | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   6/50 (12%)   1/50 (2%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/48.43      6/48.59      6/41.44      1/44.45     |0/48.25      0/46.83      2/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     12.4%        12.4%        14.5%        2.3%        |0.0%         0.0%         4.3%         4.1%         | 
|TERMINAL (d)       |     5/43 (12%)   6/46 (13%)   6/36 (17%)   1/40 (3%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     24           729 (T)      729 (T)      729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070N     P=0.576N     P=0.497      P=0.073N    |P=0.088      (e)          P=0.224      P=0.234      | 
|POLY 3             |     P=0.069N     P=0.618N     P=0.508      P=0.071N    |P=0.089      (e)          P=0.230      P=0.239      | 
|POLY 1.5           |     P=0.068N     P=0.615      P=0.521      P=0.072N    |P=0.089      (e)          P=0.230      P=0.239      | 
|POLY 6             |     P=0.070N     P=0.606N     P=0.496      P=0.071N    |P=0.090      (e)          P=0.229      P=0.239      | 
|LOGISTIC REGRESSION|     P=0.051N     P=0.610      P=0.623N     P=0.040N*   |(e)          (e)          P=0.224      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.620N     P=0.620N     P=0.056N    |P=0.087      (e)          P=0.242      P=0.247      | 
|ORDER RESTRICTED   |     P=0.064N     (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/47.66      3/48.59      2/41.44      3/44.45     |0/48.25      1/46.83      0/46.63      2/49.07      | 
|POLY-3 PERCENT (g) |     10.5%        6.2%         4.8%         6.8%        |0.0%         2.1%         0.0%         4.1%         | 
|TERMINAL (d)       |     4/43 (9%)    3/46 (7%)    2/36 (6%)    3/40 (8%)   |0/46 (0%)    1/43 (2%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.356N     P=0.323N     P=0.296N     P=0.397N    |P=0.143      P=0.487      (e)          P=0.240      | 
|POLY 3             |     P=0.340N     P=0.346N     P=0.277N     P=0.396N    |P=0.144      P=0.494      (e)          P=0.241      | 
|POLY 1.5           |     P=0.335N     P=0.351N     P=0.268N     P=0.394N    |P=0.143      P=0.495      (e)          P=0.240      | 
|POLY 6             |     P=0.345N     P=0.339N     P=0.286N     P=0.397N    |P=0.144      P=0.492      (e)          P=0.242      | 
|LOGISTIC REGRESSION|     P=0.344N     P=0.349N     P=0.274N     P=0.390N    |P=0.134      P=0.487      (e)          P=0.190      | 
|COCH-ARM / FISHERS |     P=0.297N     P=0.357N     P=0.218N     P=0.357N    |P=0.141      P=0.495      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.305N     (e)          (e)          (e)         |P=0.077      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  43/50 (86%)  32/50 (64%)  31/50 (62%) |27/50 (54%)  17/49 (35%)  21/49 (43%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     34/48.03     43/48.99     32/42.15     31/44.73    |27/50.00     17/48.38     21/48.01     19/49.28     | 
|POLY-3 PERCENT (g) |     70.8%        87.8%        75.9%        69.3%       |54.0%        35.1%        43.8%        38.6%        | 
|TERMINAL (d)       |     31/43 (72%)  41/46 (89%)  29/36 (81%)  29/40 (73%) |23/46 (50%)  14/43 (33%)  16/43 (37%)  18/45 (40%)  | 
|FIRST INCIDENCE    |     668          657          611          693         |402          400          555          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331N     P=0.106      P=0.267      P=0.524N    |P=0.167N     P=0.078N     P=0.264N     P=0.107N     | 
|POLY 3             |     P=0.253N     P=0.031 *    P=0.377      P=0.529N    |P=0.149N     P=0.045N*    P=0.209N     P=0.089N     | 
|POLY 1.5           |     P=0.235N     P=0.027 *    P=0.427      P=0.519N    |P=0.145N     P=0.043N*    P=0.207N     P=0.085N     | 
|POLY 6             |     P=0.275N     P=0.040 *    P=0.332      P=0.538N    |P=0.155N     P=0.049N*    P=0.209N     P=0.096N     | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.044 *    P=0.304      P=0.493N    |P=0.146N     P=0.031N*    P=0.173N     P=0.084N     | 
|COCH-ARM / FISHERS |     P=0.088N     P=0.028 *    P=0.417N     P=0.338N    |P=0.139N     P=0.041N*    P=0.182N     P=0.080N     | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |P=0.088N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      1/48.59      2/41.44      3/44.59     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.8%         6.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    1/46 (2%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      695         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      P=0.747N     P=0.438      P=0.286     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.144      P=0.755N     P=0.453      P=0.284     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.145      P=0.757N     P=0.459      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.143      P=0.751N     P=0.448      P=0.285     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.142      P=0.747N     P=0.438      P=0.283     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165      P=0.753N     P=0.500      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.192      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    45/50 (90%) |0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.66      0/48.59      2/41.70      45/46.00    |0/48.25      2/47.25      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.8%         97.8%       |0.0%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    1/36 (3%)    39/40 (98%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     668          ---          659          531         |---          620          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.492N     P=0.439      P<0.001 **  |P=0.404N     P=0.230      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.496N     P=0.454      P<0.001 **  |P=0.404N     P=0.233      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.498N     P=0.460      P<0.001 **  |P=0.404N     P=0.233      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.493N     P=0.449      P<0.001 **  |P=0.405N     P=0.232      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.503N     P=0.487      P<0.001 **  |P=0.407N     P=0.233      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.500      P<0.001 **  |P=0.405N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.43      0/48.59      1/42.27      0/44.45     |1/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.4%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          400          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.208N     P=0.224N     P=0.551N     P=0.254N    |P=0.309N     P=0.513N     P=0.513N     P=0.504N     | 
|POLY 3             |     P=0.201N     P=0.232N     P=0.540N     P=0.252N    |P=0.307N     P=0.506N     P=0.507N     P=0.498N     | 
|POLY 1.5           |     P=0.199N     P=0.234N     P=0.536N     P=0.252N    |P=0.307N     P=0.505N     P=0.507N     P=0.499N     | 
|POLY 6             |     P=0.204N     P=0.228N     P=0.544N     P=0.252N    |P=0.306N     P=0.508N     P=0.508N     P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.163N     (e)          P=0.457N     (e)         |P=0.309N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |P=0.306N     P=0.505N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.084N     (e)          (e)          (e)         |P=0.119N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    4/49 (8%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.43      3/48.59      1/41.44      3/44.56     |0/48.25      4/47.67      1/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         6.2%         2.4%         6.7%        |0.0%         8.4%         2.1%         2.1%         | 
|TERMINAL (d)       |     2/43 (5%)    3/46 (7%)    1/36 (3%)    2/40 (5%)   |0/46 (0%)    3/43 (7%)    1/43 (2%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      701         |---          400          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.531      P=0.562N     P=0.470     |P=0.557N     P=0.058      P=0.487      P=0.496      | 
|POLY 3             |     P=0.438      P=0.511      P=0.547N     P=0.472     |P=0.551N     P=0.059      P=0.493      P=0.502      | 
|POLY 1.5           |     P=0.440      P=0.506      P=0.541N     P=0.471     |P=0.551N     P=0.059      P=0.493      P=0.501      | 
|POLY 6             |     P=0.436      P=0.519      P=0.552N     P=0.473     |P=0.553N     P=0.058      P=0.492      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.432      P=0.531      P=0.562N     P=0.471     |P=0.566N     P=0.054      P=0.487      P=0.496      | 
|COCH-ARM / FISHERS |     P=0.477      P=0.500      P=0.500N     P=0.500     |P=0.554N     P=0.056      P=0.495      P=0.500      | 
|ORDER RESTRICTED   |     P=0.457      (e)          (e)          (e)         |P=0.178      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   6/50 (12%)   8/50 (16%)  |1/50 (2%)    0/49 (0%)    1/49 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     6/47.43      9/48.59      6/41.44      8/44.45     |1/48.25      0/46.83      1/46.63      4/48.64      | 
|POLY-3 PERCENT (g) |     12.7%        18.5%        14.5%        18.0%       |2.1%         0.0%         2.1%         8.2%         | 
|TERMINAL (d)       |     6/43 (14%)   9/46 (20%)   6/36 (17%)   8/40 (20%)  |1/46 (2%)    0/43 (0%)    1/43 (2%)    4/45 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333      P=0.337      P=0.492      P=0.330     |P=0.035 *    P=0.513N     P=0.747      P=0.174      | 
|POLY 3             |     P=0.356      P=0.306      P=0.523      P=0.337     |P=0.035 *    P=0.506N     P=0.753      P=0.182      | 
|POLY 1.5           |     P=0.360      P=0.298      P=0.536      P=0.338     |P=0.035 *    P=0.505N     P=0.753      P=0.181      | 
|POLY 6             |     P=0.351      P=0.318      P=0.512      P=0.338     |P=0.035 *    P=0.508N     P=0.752      P=0.181      | 
|LOGISTIC REGRESSION|     P=0.333      P=0.337      P=0.492      P=0.330     |P=0.035 *    (e)          P=0.747      P=0.174      | 
|COCH-ARM / FISHERS |     P=0.433      P=0.288      P=0.620N     P=0.387     |P=0.035 *    P=0.505N     P=0.747      P=0.181      | 
|ORDER RESTRICTED   |     P=0.385      (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    6/50 (12%)  |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.43      3/48.59      2/41.44      6/44.73     |0/48.25      0/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     6.3%         6.2%         4.8%         13.4%       |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     3/43 (7%)    3/46 (7%)    2/36 (6%)    5/40 (13%)  |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      654         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.116      P=0.631N     P=0.581N     P=0.211     |P=0.691      (e)          P=0.487      (e)          | 
|POLY 3             |     P=0.125      P=0.651N     P=0.561N     P=0.214     |P=0.699      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.127      P=0.656N     P=0.553N     P=0.213     |P=0.698      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.124      P=0.643N     P=0.568N     P=0.217     |P=0.699      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.122      P=0.631N     P=0.581N     P=0.212     |(e)          (e)          P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.151      P=0.661N     P=0.500N     P=0.243     |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |3/50 (6%)    3/49 (6%)    5/49 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.66      0/48.59      2/41.44      2/44.45     |3/48.25      3/47.41      5/47.19      3/49.10      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.8%         4.5%        |6.2%         6.3%         10.6%        6.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    2/40 (5%)   |3/46 (7%)    0/43 (0%)    4/43 (9%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     668          ---          729 (T)      729 (T)     |729 (T)      620          555          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217      P=0.492N     P=0.437      P=0.475     |P=0.537      P=0.634      P=0.326      P=0.655      | 
|POLY 3             |     P=0.220      P=0.496N     P=0.451      P=0.476     |P=0.552      P=0.654      P=0.345      P=0.654N     | 
|POLY 1.5           |     P=0.222      P=0.498N     P=0.458      P=0.477     |P=0.548      P=0.653      P=0.343      P=0.656N     | 
|POLY 6             |     P=0.218      P=0.493N     P=0.445      P=0.475     |P=0.555      P=0.654      P=0.345      P=0.652N     | 
|LOGISTIC REGRESSION|     P=0.225      P=0.503N     P=0.465      P=0.485     |P=0.530      P=0.657      P=0.350      P=0.650      | 
|COCH-ARM / FISHERS |     P=0.245      P=0.500N     P=0.500      P=0.500     |P=0.540      P=0.651      P=0.346      P=0.661N     | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.542      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      1/44.45     |0/48.25      0/46.83      1/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         2.1%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    1/40 (3%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.486     |P=0.072      (e)          P=0.487      P=0.234      | 
|POLY 3             |     P=0.189      (e)          (e)          P=0.487     |P=0.073      (e)          P=0.493      P=0.239      | 
|POLY 1.5           |     P=0.190      (e)          (e)          P=0.487     |P=0.072      (e)          P=0.493      P=0.239      | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.487     |P=0.073      (e)          P=0.492      P=0.239      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.486     |(e)          (e)          P=0.487      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.071      (e)          P=0.495      P=0.247      | 
|ORDER RESTRICTED   |     P=0.109      (e)          (e)          (e)         |P=0.075      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/49 (6%)    0/49 (0%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |3/48.25      3/46.83      0/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.2%         6.4%         0.0%         12.3%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |3/46 (7%)    3/43 (7%)    0/43 (0%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.157      P=0.631      P=0.134N     P=0.232      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.648      P=0.125N     P=0.247      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.159      P=0.650      P=0.125N     P=0.246      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.644      P=0.126N     P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.157      P=0.631      (e)          P=0.232      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.160      P=0.651      P=0.125N     P=0.243      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   7/50 (14%)   7/50 (14%)  |13/50 (26%)  5/49 (10%)   12/49 (24%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     5/47.43      7/48.59      7/41.53      7/44.56     |13/48.25     5/46.83      12/46.63     10/48.64     | 
|POLY-3 PERCENT (g) |     10.5%        14.4%        16.9%        15.7%       |27.0%        10.7%        25.7%        20.6%        | 
|TERMINAL (d)       |     5/43 (12%)   7/46 (15%)   6/36 (17%)   6/40 (15%)  |13/46 (28%)  5/43 (12%)   12/43 (28%)  10/45 (22%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      706          701         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276      P=0.427      P=0.265      P=0.332     |P=0.508N     P=0.047N*    P=0.578N     P=0.338N     | 
|POLY 3             |     P=0.294      P=0.397      P=0.290      P=0.336     |P=0.483N     P=0.037N*    P=0.539N     P=0.310N     | 
|POLY 1.5           |     P=0.297      P=0.389      P=0.301      P=0.336     |P=0.487N     P=0.036N*    P=0.538N     P=0.311N     | 
|POLY 6             |     P=0.292      P=0.409      P=0.281      P=0.339     |P=0.481N     P=0.039N*    P=0.546N     P=0.311N     | 
|LOGISTIC REGRESSION|     P=0.285      P=0.427      P=0.272      P=0.337     |P=0.508N     P=0.047N*    P=0.578N     P=0.338N     | 
|COCH-ARM / FISHERS |     P=0.361      P=0.380      P=0.380      P=0.380     |P=0.495N     P=0.037N*    P=0.523N     P=0.318N     | 
|ORDER RESTRICTED   |     P=0.345      (e)          (e)          (e)         |P=0.262N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    4/50 (8%)    4/50 (8%)   |4/50 (8%)    1/49 (2%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.43      3/48.60      4/41.44      4/44.45     |4/48.25      1/46.83      3/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     8.4%         6.2%         9.7%         9.0%        |8.3%         2.1%         6.4%         0.0%         | 
|TERMINAL (d)       |     4/43 (9%)    2/46 (4%)    4/36 (11%)   4/40 (10%)  |4/46 (9%)    1/43 (2%)    3/43 (7%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      726          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.447      P=0.462N     P=0.543      P=0.604     |P=0.075N     P=0.201N     P=0.537N     P=0.066N     | 
|POLY 3             |     P=0.463      P=0.487N     P=0.567      P=0.607     |P=0.069N     P=0.188N     P=0.519N     P=0.060N     | 
|POLY 1.5           |     P=0.467      P=0.493N     P=0.577      P=0.607     |P=0.070N     P=0.187N     P=0.518N     P=0.060N     | 
|POLY 6             |     P=0.459      P=0.477N     P=0.558      P=0.608     |P=0.069N     P=0.191N     P=0.522N     P=0.060N     | 
|LOGISTIC REGRESSION|     P=0.448      P=0.455N     P=0.543      P=0.604     |P=0.075N     P=0.201N     P=0.537N     (e)          | 
|COCH-ARM / FISHERS |     P=0.518      P=0.500N     P=0.643N     P=0.643N    |P=0.072N     P=0.187N     P=0.511N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.567      (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   2/50 (4%)    6/50 (12%)  |5/50 (10%)   2/49 (4%)    3/49 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/47.66      6/48.86      2/41.44      6/44.56     |5/48.25      2/47.67      3/47.89      4/49.31      | 
|POLY-3 PERCENT (g) |     4.2%         12.3%        4.8%         13.5%       |10.4%        4.2%         6.3%         8.1%         | 
|TERMINAL (d)       |     1/43 (2%)    5/46 (11%)   2/36 (6%)    5/40 (13%)  |5/46 (11%)   1/43 (2%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     668          657          729 (T)      701         |729 (T)      400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.160      P=0.627      P=0.118     |P=0.535N     P=0.244N     P=0.389N     P=0.508N     | 
|POLY 3             |     P=0.151      P=0.142      P=0.642      P=0.113     |P=0.526N     P=0.222N     P=0.361N     P=0.486N     | 
|POLY 1.5           |     P=0.153      P=0.138      P=0.650      P=0.113     |P=0.529N     P=0.222N     P=0.363N     P=0.491N     | 
|POLY 6             |     P=0.148      P=0.148      P=0.635      P=0.112     |P=0.521N     P=0.224N     P=0.361N     P=0.482N     | 
|LOGISTIC REGRESSION|     P=0.156      P=0.135      P=0.655      P=0.116     |P=0.563      P=0.217N     P=0.298N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.189      P=0.134      P=0.691N     P=0.134     |P=0.535N     P=0.226N     P=0.369N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.086      (e)          (e)          (e)         |P=0.341N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      1/41.44      0/44.45     |0/48.25      0/46.83      2/47.00      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         2.4%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    1/36 (3%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          623          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.253      P=0.465      (e)         |P=0.594      (e)          P=0.230      (e)          | 
|POLY 3             |     P=0.487N     P=0.243      P=0.473      (e)         |P=0.602      (e)          P=0.232      (e)          | 
|POLY 1.5           |     P=0.487N     P=0.240      P=0.477      (e)         |P=0.601      (e)          P=0.231      (e)          | 
|POLY 6             |     P=0.487N     P=0.247      P=0.470      (e)         |P=0.603      (e)          P=0.231      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.253      P=0.465      (e)         |P=0.593      (e)          P=0.246      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.595      (e)          P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.317      (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    11/50 (22%)  37/50 (74%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      11/41.44     37/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         26.6%        83.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    11/36 (31%)  37/40 (93%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Karyomegaly                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    10/50 (20%)  29/50 (58%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      10/41.44     29/44.45    |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         24.1%        65.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    10/36 (28%)  29/40 (73%) |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    19/50 (38%) |0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/48.72      1/41.44      19/45.62    |0/48.25      2/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.4%         41.7%       |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    1/36 (3%)    15/40 (38%) |0/46 (0%)    2/43 (5%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          696          729 (T)      531         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.522      P=0.465      P<0.001 **  |P=0.408N     P=0.224      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.505      P=0.473      P<0.001 **  |P=0.405N     P=0.231      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.503      P=0.477      P<0.001 **  |P=0.404N     P=0.232      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.509      P=0.470      P<0.001 **  |P=0.407N     P=0.229      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.499      P=0.465      P<0.001 **  |(e)          P=0.224      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |P=0.405N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.240N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.43      3/48.59      1/41.44      3/44.45     |2/48.27      0/46.83      0/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         2.4%         6.8%        |4.1%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    3/46 (7%)    1/36 (3%)    3/40 (8%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |723          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.269      P=0.330      P=0.722      P=0.280     |P=0.463N     P=0.257N     P=0.257N     P=0.508N     | 
|POLY 3             |     P=0.279      P=0.314      P=0.730      P=0.283     |P=0.459N     P=0.244N     P=0.245N     P=0.497N     | 
|POLY 1.5           |     P=0.281      P=0.310      P=0.734      P=0.283     |P=0.460N     P=0.243N     P=0.245N     P=0.498N     | 
|POLY 6             |     P=0.277      P=0.320      P=0.726      P=0.283     |P=0.458N     P=0.246N     P=0.246N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.269      P=0.330      P=0.722      P=0.280     |P=0.458N     P=0.246N     P=0.246N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.313      P=0.309      P=0.753N     P=0.309     |P=0.460N     P=0.253N     P=0.253N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.218      (e)          (e)          (e)         |P=0.132N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/49 (4%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |2/48.27      2/46.83      2/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.1%         4.3%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    2/43 (5%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |723          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.667      P=0.667      P=0.245N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.683      P=0.681      P=0.236N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.685      P=0.682      P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.679      P=0.679      P=0.236N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.163N     P=0.678      P=0.679      P=0.236N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.684      P=0.684      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   4/50 (8%)    2/50 (4%)   |4/50 (8%)    3/49 (6%)    1/49 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/47.43      8/48.72      4/41.44      2/44.72     |4/48.25      3/46.83      1/46.63      4/49.07      | 
|POLY-3 PERCENT (g) |     8.4%         16.4%        9.7%         4.5%        |8.3%         6.4%         2.1%         8.2%         | 
|TERMINAL (d)       |     4/43 (9%)    7/46 (15%)   4/36 (11%)   1/40 (3%)   |4/46 (9%)    3/43 (7%)    1/43 (2%)    3/45 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      696          729 (T)      656         |729 (T)      729 (T)      729 (T)      604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187N     P=0.216      P=0.543      P=0.371N    |P=0.576      P=0.537N     P=0.201N     P=0.633      | 
|POLY 3             |     P=0.172N     P=0.191      P=0.567      P=0.365N    |P=0.571N     P=0.516N     P=0.190N     P=0.633N     | 
|POLY 1.5           |     P=0.172N     P=0.185      P=0.577      P=0.366N    |P=0.573N     P=0.513N     P=0.189N     P=0.636N     | 
|POLY 6             |     P=0.171N     P=0.201      P=0.558      P=0.362N    |P=0.569N     P=0.521N     P=0.191N     P=0.632N     | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.199      P=0.543      P=0.363N    |P=0.575N     P=0.537N     P=0.201N     P=0.638      | 
|COCH-ARM / FISHERS |     P=0.139N     P=0.178      P=0.643N     P=0.339N    |P=0.577N     P=0.511N     P=0.187N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.151N     (e)          (e)          (e)         |P=0.420N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |9/50 (18%)   6/49 (12%)   3/49 (6%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/47.43      2/48.59      2/41.44      4/44.45     |9/48.25      6/46.83      3/46.63      7/48.67      | 
|POLY-3 PERCENT (g) |     2.1%         4.1%         4.8%         9.0%        |18.7%        12.8%        6.4%         14.4%        | 
|TERMINAL (d)       |     1/43 (2%)    2/46 (4%)    2/36 (6%)    4/40 (10%)  |9/46 (20%)   6/43 (14%)   3/43 (7%)    6/45 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.089      P=0.524      P=0.438      P=0.159     |P=0.352N     P=0.337N     P=0.078N     P=0.411N     | 
|POLY 3             |     P=0.094      P=0.508      P=0.453      P=0.160     |P=0.337N     P=0.310N     P=0.068N     P=0.386N     | 
|POLY 1.5           |     P=0.096      P=0.505      P=0.459      P=0.160     |P=0.339N     P=0.306N     P=0.068N     P=0.387N     | 
|POLY 6             |     P=0.093      P=0.514      P=0.448      P=0.160     |P=0.336N     P=0.316N     P=0.069N     P=0.386N     | 
|LOGISTIC REGRESSION|     P=0.089      P=0.524      P=0.438      P=0.159     |P=0.338N     P=0.337N     P=0.078N     P=0.392N     | 
|COCH-ARM / FISHERS |     P=0.113      P=0.500      P=0.500      P=0.181     |P=0.343N     P=0.303N     P=0.065N     P=0.393N     | 
|ORDER RESTRICTED   |     P=0.097      (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    4/50 (8%)    2/50 (4%)   |2/50 (4%)    2/49 (4%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.43      4/48.59      4/41.44      2/44.45     |2/48.25      2/47.16      3/46.67      0/48.64      | 
|POLY-3 PERCENT (g) |     8.4%         8.2%         9.7%         4.5%        |4.2%         4.2%         6.4%         0.0%         | 
|TERMINAL (d)       |     4/43 (9%)    4/46 (9%)    4/36 (11%)   2/40 (5%)   |2/46 (4%)    1/43 (2%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      639          720          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.606N     P=0.543      P=0.371N    |P=0.204N     P=0.671      P=0.470      P=0.243N     | 
|POLY 3             |     P=0.301N     P=0.629N     P=0.567      P=0.368N    |P=0.196N     P=0.685      P=0.485      P=0.236N     | 
|POLY 1.5           |     P=0.299N     P=0.635N     P=0.577      P=0.368N    |P=0.197N     P=0.686      P=0.485      P=0.236N     | 
|POLY 6             |     P=0.304N     P=0.620N     P=0.558      P=0.367N    |P=0.196N     P=0.684      P=0.483      P=0.236N     | 
|LOGISTIC REGRESSION|     P=0.313N     P=0.606N     P=0.543      P=0.371N    |P=0.199N     P=0.690      P=0.479      (e)          | 
|COCH-ARM / FISHERS |     P=0.256N     P=0.643N     P=0.643N     P=0.339N    |P=0.199N     P=0.684      P=0.490      P=0.247N     | 
|ORDER RESTRICTED   |     P=0.356N     (e)          (e)          (e)         |P=0.150N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      1/42.27      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          400          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063      (e)          P=0.483      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.062      (e)          P=0.477      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.062      (e)          P=0.479      P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.061      (e)          P=0.475      P=0.223     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.077      (e)          P=0.634      P=0.223     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      0/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      (e)          P=0.200      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.567      (e)          P=0.209      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.567      (e)          P=0.212      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.568      (e)          P=0.205      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.200      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.220      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    2/49 (4%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/47.43      3/48.59      1/41.44      3/44.45     |1/48.25      2/46.83      3/46.63      2/48.64      | 
|POLY-3 PERCENT (g) |     10.5%        6.2%         2.4%         6.8%        |2.1%         4.3%         6.4%         4.1%         | 
|TERMINAL (d)       |     5/43 (12%)   3/46 (7%)    1/36 (3%)    3/40 (8%)   |1/46 (2%)    2/43 (5%)    3/43 (7%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.320N     P=0.148N     P=0.396N    |P=0.401      P=0.476      P=0.282      P=0.492      | 
|POLY 3             |     P=0.309N     P=0.344N     P=0.136N     P=0.393N    |P=0.412      P=0.490      P=0.293      P=0.503      | 
|POLY 1.5           |     P=0.305N     P=0.350N     P=0.131N     P=0.393N    |P=0.411      P=0.491      P=0.294      P=0.502      | 
|POLY 6             |     P=0.313N     P=0.334N     P=0.140N     P=0.392N    |P=0.412      P=0.486      P=0.291      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.327N     P=0.320N     P=0.148N     P=0.396N    |P=0.401      P=0.476      P=0.282      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.273N     P=0.357N     P=0.102N     P=0.357N    |P=0.406      P=0.492      P=0.301      P=0.500      | 
|ORDER RESTRICTED   |     P=0.200N     (e)          (e)          (e)         |P=0.346      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/46 (0%)    2/45 (4%)    4/50 (8%)   |0/48 (0%)    0/48 (0%)    2/46 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/46.11      0/45.59      2/37.94      4/47.72     |0/46.25      0/46.26      2/45.36      0/47.07      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         5.3%         8.4%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |0/44 (0%)    0/43 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     611          ---          7            7           |---          ---          128          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.500N     P=0.464      P=0.173     |P=0.595      (e)          P=0.238      (e)          | 
|POLY 3             |     P=0.043 *    P=0.502N     P=0.433      P=0.190     |P=0.603      (e)          P=0.233      (e)          | 
|POLY 1.5           |     P=0.044 *    P=0.503N     P=0.440      P=0.190     |P=0.600      (e)          P=0.231      (e)          | 
|POLY 6             |     P=0.042 *    P=0.501N     P=0.426      P=0.189     |P=0.605      (e)          P=0.234      (e)          | 
|LOGISTIC REGRESSION|     P=0.170      P=0.578N     P=0.709      P=0.494     |P=0.547      (e)          P=0.273      (e)          | 
|COCH-ARM / FISHERS |     P=0.047 *    P=0.511N     P=0.476      P=0.194     |P=0.594      (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |     P=0.043 *    (e)          (e)          (e)         |P=0.243      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/46 (0%)    0/45 (0%)    0/50 (0%)   |3/48 (6%)    0/48 (0%)    0/46 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.70      0/45.59      0/36.53      0/44.45     |3/46.25      0/46.26      0/43.81      0/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |3/44 (7%)    0/43 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049N*    P=0.125N     P=0.130N     P=0.121N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.116N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.117N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.119N     P=0.129N     P=0.115N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.049N*    (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.048N*    P=0.121N     P=0.129N     P=0.121N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.007N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/46 (0%)    0/45 (0%)    0/50 (0%)   |2/48 (4%)    1/48 (2%)    4/46 (9%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/45.70      0/45.59      0/36.53      0/44.45     |2/46.25      1/46.26      4/44.18      0/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         2.2%         9.1%         0.0%         | 
|TERMINAL (d)       |     0/42 (0%)    0/43 (0%)    0/32 (0%)    0/40 (0%)   |2/44 (5%)    1/43 (2%)    3/42 (7%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      623          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.280N     P=0.508N     P=0.319      P=0.238N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.272N     P=0.500N     P=0.316      P=0.233N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.275N     P=0.500N     P=0.315      P=0.235N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.270N     P=0.501N     P=0.318      P=0.233N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.282N     P=0.508N     P=0.317      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.282N     P=0.500N     P=0.318      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.147N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/48 (21%)  14/46 (30%)  9/45 (20%)   13/50 (26%) |11/48 (23%)  12/48 (25%)  10/46 (22%)  15/48 (31%)  | 
|POLY-3 RATE (b)    |     10/45.70     14/45.86     9/36.95      13/44.70    |11/46.25     12/46.64     10/43.81     15/47.10     | 
|POLY-3 PERCENT (g) |     21.9%        30.5%        24.4%        29.1%       |23.8%        25.7%        22.8%        31.8%        | 
|TERMINAL (d)       |     10/42 (24%)  13/43 (30%)  7/32 (22%)   11/40 (28%) |11/44 (25%)  11/43 (26%)  10/42 (24%)  14/44 (32%)  | 
|FIRST INCIDENCE    |     729 (T)      657          623          693         |729 (T)      620          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296      P=0.262      P=0.454      P=0.273     |P=0.219      P=0.475      P=0.549N     P=0.246      | 
|POLY 3             |     P=0.337      P=0.242      P=0.499      P=0.294     |P=0.224      P=0.509      P=0.556N     P=0.263      | 
|POLY 1.5           |     P=0.342      P=0.232      P=0.516      P=0.294     |P=0.220      P=0.506      P=0.556N     P=0.258      | 
|POLY 6             |     P=0.333      P=0.257      P=0.485      P=0.297     |P=0.227      P=0.511      P=0.559N     P=0.267      | 
|LOGISTIC REGRESSION|     P=0.328      P=0.243      P=0.471      P=0.285     |P=0.230      P=0.500      P=0.549N     P=0.263      | 
|COCH-ARM / FISHERS |     P=0.445      P=0.203      P=0.563N     P=0.358     |P=0.212      P=0.500      P=0.544N     P=0.246      | 
|ORDER RESTRICTED   |     P=0.341      (e)          (e)          (e)         |P=0.297      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/48 (17%)   6/46 (13%)   9/45 (20%)   6/50 (12%)  |24/48 (50%)  20/48 (42%)  21/46 (46%)  21/48 (44%)  | 
|POLY-3 RATE (b)    |     8/46.11      6/45.72      9/37.59      6/44.72     |24/47.17     20/46.97     21/45.74     21/47.31     | 
|POLY-3 PERCENT (g) |     17.4%        13.1%        23.9%        13.4%       |50.9%        42.6%        45.9%        44.4%        | 
|TERMINAL (d)       |     7/42 (17%)   5/43 (12%)   7/32 (22%)   5/40 (13%)  |21/44 (48%)  18/43 (42%)  18/42 (43%)  20/44 (46%)  | 
|FIRST INCIDENCE    |     611          696          512          656         |533          620          128          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.485N     P=0.367N     P=0.289      P=0.429N    |P=0.367N     P=0.319N     P=0.425N     P=0.348N     | 
|POLY 3             |     P=0.454N     P=0.393N     P=0.320      P=0.410N    |P=0.364N     P=0.275N     P=0.394N     P=0.336N     | 
|POLY 1.5           |     P=0.447N     P=0.398N     P=0.333      P=0.408N    |P=0.365N     P=0.272N     P=0.398N     P=0.336N     | 
|POLY 6             |     P=0.460N     P=0.385N     P=0.309      P=0.412N    |P=0.366N     P=0.280N     P=0.396N     P=0.341N     | 
|LOGISTIC REGRESSION|     P=0.423N     P=0.414N     P=0.354      P=0.397N    |P=0.385N     P=0.269N     P=0.395N     P=0.332N     | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.420N     P=0.441      P=0.355N    |P=0.374N     P=0.270N     P=0.415N     P=0.341N     | 
|ORDER RESTRICTED   |     P=0.451N     (e)          (e)          (e)         |P=0.412N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    1/47 (2%)    2/46 (4%)    2/48 (4%)   |0/48 (0%)    0/48 (0%)    0/47 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/44.84      1/46.72      2/41.81      2/44.86     |0/46.25      0/45.83      0/44.67      0/47.07      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         4.8%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/36 (0%)    0/40 (0%)   |0/44 (0%)    0/42 (0%)    0/42 (0%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     611          696          7            7           |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313      P=0.748N     P=0.461      P=0.480     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.330      P=0.751N     P=0.476      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.331      P=0.753N     P=0.481      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.330      P=0.748N     P=0.471      P=0.502     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.571      P=0.727      P=0.620      P=0.659     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.344      P=0.753N     P=0.492      P=0.508     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.415      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/46 (0%)    0/48 (0%)   |5/48 (10%)   3/48 (6%)    0/47 (0%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/44.43      0/46.59      0/40.71      0/43.59     |5/46.25      3/45.83      0/44.67      3/47.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |10.8%        6.6%         0.0%         6.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/36 (0%)    0/40 (0%)   |5/44 (11%)   3/42 (7%)    0/42 (0%)    3/44 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.382N     P=0.038N*    P=0.356N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.362N     P=0.033N*    P=0.347N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.359N     P=0.033N*    P=0.350N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.243N     P=0.366N     P=0.034N*    P=0.345N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.245N     P=0.382N     (e)          P=0.356N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.249N     P=0.357N     P=0.030N*    P=0.357N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    2/47 (4%)    2/46 (4%)    0/48 (0%)   |0/48 (0%)    1/48 (2%)    0/47 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     4/44.43      2/46.59      2/40.71      0/43.59     |0/46.25      1/46.16      0/44.67      1/47.07      | 
|POLY-3 PERCENT (g) |     9.0%         4.3%         4.9%         0.0%        |0.0%         2.2%         0.0%         2.1%         | 
|TERMINAL (d)       |     4/40 (10%)   2/44 (5%)    2/36 (6%)    0/40 (0%)   |0/44 (0%)    0/42 (0%)    0/42 (0%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          639          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.294N     P=0.386N     P=0.063N    |P=0.408      P=0.492      (e)          P=0.500      | 
|POLY 3             |     P=0.049N*    P=0.316N     P=0.378N     P=0.063N    |P=0.410      P=0.500      (e)          P=0.504      | 
|POLY 1.5           |     P=0.049N*    P=0.321N     P=0.372N     P=0.063N    |P=0.408      P=0.500      (e)          P=0.502      | 
|POLY 6             |     P=0.050N     P=0.307N     P=0.383N     P=0.062N    |P=0.410      P=0.499      (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.049N*    P=0.294N     P=0.386N     (e)         |P=0.396      P=0.500      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.043N*    P=0.339N     P=0.349N     P=0.056N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.029N*    (e)          (e)          (e)         |P=0.255      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/47 (15%)   7/47 (15%)   15/46 (33%)  10/48 (21%) |3/48 (6%)    7/48 (15%)   4/47 (9%)    6/48 (13%)   | 
|POLY-3 RATE (b)    |     7/44.70      7/46.59      15/40.71     10/43.59    |3/46.25      7/46.22      4/44.67      6/47.10      | 
|POLY-3 PERCENT (g) |     15.7%        15.0%        36.8%        22.9%       |6.5%         15.2%        9.0%         12.7%        | 
|TERMINAL (d)       |     6/40 (15%)   7/44 (16%)   15/36 (42%)  10/40 (25%) |3/44 (7%)    6/42 (14%)   4/42 (10%)   5/44 (11%)   | 
|FIRST INCIDENCE    |     657          729 (T)      729 (T)      729 (T)     |729 (T)      620          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.541N     P=0.021 *    P=0.292     |P=0.325      P=0.144      P=0.475      P=0.245      | 
|POLY 3             |     P=0.132      P=0.581N     P=0.021 *    P=0.276     |P=0.327      P=0.157      P=0.481      P=0.252      | 
|POLY 1.5           |     P=0.136      P=0.588N     P=0.024 *    P=0.277     |P=0.323      P=0.158      P=0.482      P=0.249      | 
|POLY 6             |     P=0.128      P=0.570N     P=0.019 *    P=0.276     |P=0.330      P=0.156      P=0.478      P=0.254      | 
|LOGISTIC REGRESSION|     P=0.142      P=0.583N     P=0.022 *    P=0.285     |P=0.326      P=0.157      P=0.475      P=0.252      | 
|COCH-ARM / FISHERS |     P=0.188      P=0.613N     P=0.038 *    P=0.314     |P=0.315      P=0.158      P=0.488      P=0.243      | 
|ORDER RESTRICTED   |     P=0.075      (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Bronchial                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     1/3 (33%)    0/0 (0%)     0/1 (0%)    |1/12 (8%)    0/6 (0%)     0/8 (0%)     2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       1/3.00       0/0.00       0/0.87      |1/12.00      0/5.84       0/7.18       2/9.00       | 
|POLY-3 PERCENT (g) |     0.0%         33.3%        0.0%         0.0%        |8.3%         0.0%         0.0%         22.2%        | 
|TERMINAL (d)       |     0/1 (0%)     1/3 (33%)    0/0 (0%)     0/0 (0%)    |1/12 (8%)    0/5 (0%)     0/6 (0%)     1/8 (13%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      ---          ---          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.958      P=0.718      (e)          (e)         |P=0.219      P=0.674N     P=0.638N     P=0.406      | 
|POLY 3             |     (e)          P=0.604      (e)          (e)         |P=0.218      P=0.641N     P=0.600N     P=0.397      | 
|POLY 1.5           |     (e)          P=0.591      (e)          (e)         |P=0.218      P=0.639N     P=0.592N     P=0.397      | 
|POLY 6             |     (e)          P=0.625      (e)          (e)         |P=0.217      P=0.645N     P=0.611N     P=0.397      | 
|LOGISTIC REGRESSION|     (e)          P=0.718      (e)          (e)         |P=0.217      (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.752N     P=0.600      (e)          (e)         |P=0.217      P=0.667N     P=0.600N     P=0.388      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.088      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |2/12 (17%)   1/6 (17%)    1/8 (13%)    0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |2/12.00      1/5.84       1/7.18       0/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |16.7%        17.1%        13.9%        0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |2/12 (17%)   1/5 (20%)    1/6 (17%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.222N     P=0.698      P=0.743      P=0.328N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.729      P=0.677N     P=0.298N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.197N     P=0.733      P=0.662N     P=0.298N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.723      P=0.696N     P=0.299N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.222N     P=0.698      P=0.743      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.730      P=0.656N     P=0.314N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.161N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |5/12 (42%)   3/6 (50%)    4/8 (50%)    2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |5/12.00      3/5.84       4/7.74       2/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |41.7%        51.4%        51.7%        22.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |5/12 (42%)   3/5 (60%)    3/6 (50%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.311N     P=0.440      P=0.385      P=0.390N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.545      P=0.510      P=0.327N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.554      P=0.521      P=0.326N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.249N     P=0.530      P=0.490      P=0.329N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.230N     P=0.440      P=0.653      P=0.390N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.240N     P=0.563      P=0.535      P=0.324N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.178N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |1/12 (8%)    1/6 (17%)    2/8 (25%)    2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |1/12.00      1/5.84       2/7.18       2/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.3%         17.1%        27.9%        22.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |1/12 (8%)    1/5 (20%)    2/6 (33%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.241      P=0.556      P=0.257      P=0.354      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.284      P=0.593      P=0.317      P=0.395      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.285      P=0.596      P=0.333      P=0.396      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.283      P=0.587      P=0.297      P=0.394      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.241      P=0.556      P=0.257      P=0.354      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.278      P=0.569      P=0.344      P=0.388      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/3 (0%)     0/0 (0%)     0/1 (0%)    |3/12 (25%)   1/6 (17%)    2/8 (25%)    0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/1.71       0/3.00       0/0.00       0/0.87      |3/12.00      1/5.84       2/7.18       0/8.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |25.0%        17.1%        27.9%        0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |3/12 (25%)   1/5 (20%)    2/6 (33%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.165N     P=0.653N     P=0.572      P=0.192N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.586N     P=0.646      P=0.158N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.581N     P=0.666      P=0.157N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.595N     P=0.618      P=0.159N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.165N     P=0.653N     P=0.572      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.593N     P=0.693      P=0.165N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.082N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/49 (4%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |0/48.08      2/47.64      0/46.63      2/48.67      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.2%         0.0%         4.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          606          ---          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.252      P=0.237      (e)          P=0.237      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.249      P=0.235      (e)          P=0.240      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.251      P=0.236      (e)          P=0.241      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.248      P=0.235      (e)          P=0.239      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.250      P=0.341      (e)          P=0.240      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.253      P=0.247      (e)          P=0.253      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/6 (67%)    1/2 (50%)    3/5 (60%)    2/2 (100%)  |2/3 (67%)    3/4 (75%)    6/6 (100%)   6/6 (100%)   | 
|POLY-3 RATE (b)    |     4/6.00       1/2.00       3/5.00       2/2.00      |2/3.00       3/4.00       6/6.00       6/6.00       | 
|POLY-3 PERCENT (g) |     66.7%        50.0%        60.0%        100.0%      |66.7%        75.0%        100.0%       100.0%       | 
|TERMINAL (d)       |     4/6 (67%)    1/2 (50%)    2/4 (50%)    2/2 (100%)  |2/3 (67%)    3/4 (75%)    5/5 (100%)   3/3 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          729 (T)     |729 (T)      729 (T)      128          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401      P=0.653N     P=0.650      P=0.500     |P=0.008 **   P=0.712      P=0.185      P=0.068      | 
|POLY 3             |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|POLY 1.5           |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|POLY 6             |     P=0.404      P=0.644N     P=0.642N     P=0.500     |P=0.127      P=0.696      P=0.351      P=0.351      | 
|LOGISTIC REGRESSION|     P=0.401      P=0.653N     (e)          P=0.500     |P=0.008 **   P=0.712      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.393      P=0.643N     P=0.652N     P=0.536     |P=0.127      P=0.714      P=0.333      P=0.333      | 
|ORDER RESTRICTED   |     P=0.363      (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      3/48.59      3/41.70      2/44.45     |0/48.25      1/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         7.2%         4.5%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    3/46 (7%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    1/43 (2%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.330      P=0.247      P=0.475     |P=0.568N     P=0.487      (e)          (e)          | 
|POLY 3             |     P=0.431      P=0.314      P=0.261      P=0.477     |P=0.568N     P=0.494      (e)          (e)          | 
|POLY 1.5           |     P=0.433      P=0.310      P=0.266      P=0.477     |P=0.567N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.430      P=0.320      P=0.257      P=0.478     |P=0.569N     P=0.492      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.437      P=0.330      P=0.266      P=0.475     |(e)          P=0.487      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.477      P=0.309      P=0.309      P=0.500     |P=0.566N     P=0.495      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.316      (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.43      4/48.59      3/41.70      2/44.45     |0/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         8.2%         7.2%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/43 (2%)    4/46 (9%)    2/36 (6%)    2/40 (5%)   |0/46 (0%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488      P=0.201      P=0.247      P=0.475     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.494      P=0.187      P=0.261      P=0.477     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.496      P=0.183      P=0.266      P=0.477     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.494      P=0.192      P=0.257      P=0.478     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.501      P=0.201      P=0.266      P=0.475     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.544      P=0.181      P=0.309      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.268      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  7/49 (14%)   8/49 (16%)   8/48 (17%)   | 
|POLY-3 RATE (b)    |                                                        |12/48.53     7/47.16      8/46.89      8/46.64      | 
|POLY-3 PERCENT (g) |                                                        |24.7%        14.8%        17.1%        17.2%        | 
|TERMINAL (d)       |                                                        |11/46 (24%)  6/43 (14%)   7/43 (16%)   8/43 (19%)   | 
|FIRST INCIDENCE    |                                                        |651          639          658          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.295N     P=0.199N     P=0.281N     P=0.278N     | 
|POLY 3             |                                                        |P=0.281N     P=0.170N     P=0.253N     P=0.257N     | 
|POLY 1.5           |                                                        |P=0.281N     P=0.168N     P=0.252N     P=0.256N     | 
|POLY 6             |                                                        |P=0.284N     P=0.175N     P=0.257N     P=0.263N     | 
|LOGISTIC REGRESSION|                                                        |P=0.278N     P=0.168N     P=0.250N     P=0.253N     | 
|COCH-ARM / FISHERS |                                                        |P=0.283N     P=0.166N     P=0.242N     P=0.259N     | 
|ORDER RESTRICTED   |                                                        |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  11/49 (22%)  15/49 (31%)  10/48 (21%)  | 
|POLY-3 RATE (b)    |                                                        |10/48.25     11/46.87     15/46.89     10/47.28     | 
|POLY-3 PERCENT (g) |                                                        |20.7%        23.5%        32.0%        21.2%        | 
|TERMINAL (d)       |                                                        |10/46 (22%)  10/43 (23%)  14/43 (33%)  9/43 (21%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      720          658          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.466      P=0.431      P=0.133      P=0.537      | 
|POLY 3             |                                                        |P=0.511      P=0.470      P=0.155      P=0.579      | 
|POLY 1.5           |                                                        |P=0.501      P=0.475      P=0.155      P=0.573      | 
|POLY 6             |                                                        |P=0.518      P=0.462      P=0.154      P=0.581      | 
|LOGISTIC REGRESSION|                                                        |P=0.488      P=0.437      P=0.148      P=0.559      | 
|COCH-ARM / FISHERS |                                                        |P=0.480      P=0.479      P=0.163      P=0.558      | 
|ORDER RESTRICTED   |                                                        |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/49 (0%)    2/49 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/48.25      0/46.83      2/46.63      0/46.64      | 
|POLY-3 PERCENT (g) |                                                        |6.2%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |                                                        |3/46 (7%)    0/43 (0%)    2/43 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.136N     P=0.134N     P=0.531N     P=0.134N     | 
|POLY 3             |                                                        |P=0.128N     P=0.124N     P=0.515N     P=0.125N     | 
|POLY 1.5           |                                                        |P=0.129N     P=0.123N     P=0.515N     P=0.125N     | 
|POLY 6             |                                                        |P=0.127N     P=0.126N     P=0.518N     P=0.125N     | 
|LOGISTIC REGRESSION|                                                        |P=0.136N     (e)          P=0.531N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.131N     P=0.125N     P=0.510N     P=0.129N     | 
|ORDER RESTRICTED   |                                                        |P=0.040N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/49 (6%)    2/50 (4%)   |1/50 (2%)    1/49 (2%)    1/48 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      0/48.59      3/41.48      2/44.45     |1/48.25      1/46.83      1/45.67      2/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         7.2%         4.5%        |2.1%         2.1%         2.2%         4.1%         | 
|TERMINAL (d)       |     2/43 (5%)    0/46 (0%)    2/36 (6%)    2/40 (5%)   |1/46 (2%)    1/43 (2%)    1/43 (2%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          718          729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377      P=0.224N     P=0.422      P=0.669     |P=0.350      P=0.747      P=0.747      P=0.492      | 
|POLY 3             |     P=0.385      P=0.232N     P=0.439      P=0.670     |P=0.357      P=0.754      P=0.748      P=0.503      | 
|POLY 1.5           |     P=0.387      P=0.234N     P=0.447      P=0.670     |P=0.356      P=0.755      P=0.748      P=0.502      | 
|POLY 6             |     P=0.381      P=0.228N     P=0.433      P=0.671     |P=0.357      P=0.752      P=0.747      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.382      (e)          P=0.428      P=0.669     |P=0.350      P=0.747      P=0.747      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.422      P=0.247N     P=0.490      P=0.691N    |P=0.353      P=0.747      P=0.742      P=0.500      | 
|ORDER RESTRICTED   |     P=0.279      (e)          (e)          (e)         |P=0.419      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    2/48 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      2/41.44      1/45.07     |0/48.25      0/46.83      2/45.67      1/49.28      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.2%        |0.0%         0.0%         4.4%         2.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    2/36 (6%)    0/40 (0%)   |0/46 (0%)    0/43 (0%)    2/43 (5%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      531         |---          ---          729 (T)      517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226      (e)          P=0.200      P=0.487     |P=0.250      (e)          P=0.224      P=0.504      | 
|POLY 3             |     P=0.227      (e)          P=0.208      P=0.490     |P=0.258      (e)          P=0.225      P=0.504      | 
|POLY 1.5           |     P=0.225      (e)          P=0.212      P=0.489     |P=0.255      (e)          P=0.225      P=0.503      | 
|POLY 6             |     P=0.228      (e)          P=0.205      P=0.491     |P=0.260      (e)          P=0.224      P=0.505      | 
|LOGISTIC REGRESSION|     P=0.252      (e)          P=0.200      P=0.559     |P=0.233      (e)          P=0.224      P=0.268      | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.242      P=0.500     |P=0.248      (e)          P=0.237      P=0.500      | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    1/47 (2%)    2/45 (4%)    1/48 (2%)   |0/48 (0%)    1/46 (2%)    1/45 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     3/46.66      1/45.59      2/37.37      1/43.00     |0/46.25      1/44.58      1/42.89      1/47.07      | 
|POLY-3 PERCENT (g) |     6.4%         2.2%         5.4%         2.3%        |0.0%         2.2%         2.3%         2.1%         | 
|TERMINAL (d)       |     3/43 (7%)    1/43 (2%)    2/33 (6%)    1/40 (3%)   |0/44 (0%)    0/41 (0%)    1/40 (3%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.305N     P=0.620N     P=0.331N    |P=0.389      P=0.492      P=0.481      P=0.500      | 
|POLY 3             |     P=0.315N     P=0.314N     P=0.600N     P=0.335N    |P=0.395      P=0.493      P=0.485      P=0.504      | 
|POLY 1.5           |     P=0.314N     P=0.317N     P=0.593N     P=0.336N    |P=0.393      P=0.492      P=0.485      P=0.502      | 
|POLY 6             |     P=0.316N     P=0.309N     P=0.605N     P=0.333N    |P=0.396      P=0.493      P=0.485      P=0.504      | 
|LOGISTIC REGRESSION|     P=0.318N     P=0.305N     P=0.620N     P=0.331N    |P=0.381      P=0.488      P=0.481      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.287N     P=0.324N     P=0.541N     P=0.316N    |P=0.387      P=0.489      P=0.484      P=0.500      | 
|ORDER RESTRICTED   |     P=0.254N     (e)          (e)          (e)         |P=0.313      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    1/47 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/47.59      0/40.85      0/44.45     |0/48.25      3/46.83      1/44.81      1/47.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         6.4%         2.2%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/45 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    3/43 (7%)    1/43 (2%)    1/44 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.580      P=0.110      P=0.487      P=0.491      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.587      P=0.114      P=0.485      P=0.497      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.586      P=0.115      P=0.485      P=0.497      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.585      P=0.112      P=0.485      P=0.497      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.110      P=0.487      P=0.491      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.583      P=0.117      P=0.485      P=0.495      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/48 (2%)    2/48 (4%)    2/50 (4%)   |1/50 (2%)    3/49 (6%)    1/47 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/47.43      1/47.59      2/40.85      2/44.45     |1/48.25      3/46.83      1/44.81      0/47.64      | 
|POLY-3 PERCENT (g) |     4.2%         2.1%         4.9%         4.5%        |2.1%         6.4%         2.2%         0.0%         | 
|TERMINAL (d)       |     2/43 (5%)    1/45 (2%)    2/36 (6%)    2/40 (5%)   |1/46 (2%)    3/43 (7%)    1/43 (2%)    0/44 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.482      P=0.484N     P=0.629      P=0.669     |P=0.209N     P=0.282      P=0.747      P=0.509N     | 
|POLY 3             |     P=0.490      P=0.499N     P=0.639      P=0.670     |P=0.205N     P=0.295      P=0.744      P=0.503N     | 
|POLY 1.5           |     P=0.492      P=0.503N     P=0.644      P=0.670     |P=0.205N     P=0.297      P=0.744      P=0.503N     | 
|POLY 6             |     P=0.487      P=0.493N     P=0.635      P=0.671     |P=0.206N     P=0.292      P=0.743      P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.482      P=0.484N     P=0.629      P=0.669     |P=0.209N     P=0.282      P=0.747      (e)          | 
|COCH-ARM / FISHERS |     P=0.536      P=0.508N     P=0.684      P=0.684N    |P=0.206N     P=0.301      P=0.737      P=0.505N     | 
|ORDER RESTRICTED   |     P=0.552      (e)          (e)          (e)         |P=0.151N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/48 (2%)    0/48 (0%)    0/50 (0%)   |1/50 (2%)    2/49 (4%)    1/47 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/47.59      0/40.85      0/44.45     |1/48.25      2/46.83      1/44.81      2/47.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.1%         4.3%         2.2%         4.2%         | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    2/43 (5%)    1/43 (2%)    2/44 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.583N     P=0.509      (e)          (e)         |P=0.433      P=0.476      P=0.747      P=0.484      | 
|POLY 3             |     P=0.575N     P=0.501      (e)          (e)         |P=0.441      P=0.490      P=0.744      P=0.496      | 
|POLY 1.5           |     P=0.575N     P=0.498      (e)          (e)         |P=0.440      P=0.491      P=0.744      P=0.495      | 
|POLY 6             |     P=0.574N     P=0.504      (e)          (e)         |P=0.440      P=0.486      P=0.743      P=0.495      | 
|LOGISTIC REGRESSION|     (e)          P=0.509      (e)          (e)         |P=0.433      P=0.476      P=0.747      P=0.484      | 
|COCH-ARM / FISHERS |     P=0.563N     P=0.495      (e)          (e)         |P=0.437      P=0.492      P=0.737      P=0.492      | 
|ORDER RESTRICTED   |     P=0.393N     (e)          (e)          (e)         |P=0.438      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  23/50 (46%)  16/50 (32%)  21/50 (42%) |                                                    | 
|POLY-3 RATE (b)    |     18/47.95     23/48.99     16/41.94     21/44.72    |                                                    | 
|POLY-3 PERCENT (g) |     37.5%        47.0%        38.2%        47.0%       |                                                    | 
|TERMINAL (d)       |     16/43 (37%)  21/46 (46%)  14/36 (39%)  20/40 (50%) |                                                    | 
|FIRST INCIDENCE    |     650          657          611          656         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261      P=0.301      P=0.501      P=0.242     |                                                    | 
|POLY 3             |     P=0.287      P=0.233      P=0.562      P=0.240     |                                                    | 
|POLY 1.5           |     P=0.300      P=0.221      P=0.583N     P=0.244     |                                                    | 
|POLY 6             |     P=0.273      P=0.252      P=0.540      P=0.236     |                                                    | 
|LOGISTIC REGRESSION|     P=0.292      P=0.224      P=0.555      P=0.247     |                                                    | 
|COCH-ARM / FISHERS |     P=0.442      P=0.208      P=0.417N     P=0.341     |                                                    | 
|ORDER RESTRICTED   |     P=0.284      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  14/50 (28%)  7/50 (14%)  |                                                    | 
|POLY-3 RATE (b)    |     14/48.07     10/48.59     14/41.48     7/44.45     |                                                    | 
|POLY-3 PERCENT (g) |     29.1%        20.6%        33.8%        15.8%       |                                                    | 
|TERMINAL (d)       |     12/43 (28%)  10/46 (22%)  13/36 (36%)  7/40 (18%)  |                                                    | 
|FIRST INCIDENCE    |     611          729 (T)      718          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.155N     P=0.192N     P=0.372      P=0.101N    |                                                    | 
|POLY 3             |     P=0.142N     P=0.232N     P=0.405      P=0.099N    |                                                    | 
|POLY 1.5           |     P=0.136N     P=0.236N     P=0.434      P=0.096N    |                                                    | 
|POLY 6             |     P=0.149N     P=0.224N     P=0.376      P=0.101N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.139N     P=0.229N     P=0.407      P=0.092N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.241N     P=0.588N     P=0.070N    |                                                    | 
|ORDER RESTRICTED   |     P=0.100N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.43      0/48.59      0/40.44      2/45.07     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |                                                    | 
|TERMINAL (d)       |     0/42 (0%)    0/46 (0%)    0/35 (0%)    1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          531         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    (e)          (e)          P=0.228     |                                                    | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.231     |                                                    | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.229     |                                                    | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.232     |                                                    | 
|LOGISTIC REGRESSION|     P=0.050      (e)          (e)          P=0.259     |                                                    | 
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |                                                    | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |2/49.08      0/46.83      0/46.63      1/48.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.1%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |402          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.462N     P=0.252N     P=0.252N     P=0.505N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.463N     P=0.248N     P=0.249N     P=0.507N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.464N     P=0.246N     P=0.247N     P=0.507N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.251N     P=0.251N     P=0.507N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.478N     P=0.221N     P=0.149N     P=0.660N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.465N     P=0.253N     P=0.253N     P=0.508N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.138N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    5/49 (10%)   3/49 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/47.43      2/48.59      0/41.44      0/44.45     |0/48.25      5/46.83      3/46.63      2/48.07      | 
|POLY-3 PERCENT (g) |     4.2%         4.1%         0.0%         0.0%        |0.0%         10.7%        6.4%         4.2%         | 
|TERMINAL (d)       |     2/43 (5%)    2/46 (4%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    5/43 (12%)   3/43 (7%)    2/45 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101N     P=0.670N     P=0.278N     P=0.254N    |P=0.453      P=0.028 *    P=0.110      P=0.234      | 
|POLY 3             |     P=0.096N     P=0.685N     P=0.269N     P=0.252N    |P=0.460      P=0.028 *    P=0.113      P=0.237      | 
|POLY 1.5           |     P=0.095N     P=0.689N     P=0.264N     P=0.252N    |P=0.456      P=0.029 *    P=0.113      P=0.235      | 
|POLY 6             |     P=0.097N     P=0.679N     P=0.272N     P=0.252N    |P=0.462      P=0.027 *    P=0.112      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.101N     P=0.670N     (e)          (e)         |(e)          P=0.028 *    P=0.110      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.691N     P=0.247N     P=0.247N    |P=0.449      P=0.027 *    P=0.117      P=0.242      | 
|ORDER RESTRICTED   |     P=0.129N     (e)          (e)          (e)         |P=0.088      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/49 (8%)    3/50 (6%)   |0/50 (0%)    1/49 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      1/49.59      4/44.71      3/47.45     |0/48.25      1/46.83      1/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         9.0%         6.3%        |0.0%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |0/46 (0%)    1/43 (2%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          40           7            7           |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070      P=0.504      P=0.063      P=0.120     |P=0.595N     P=0.487      P=0.487      (e)          | 
|POLY 3             |     P=0.068      P=0.509      P=0.053      P=0.119     |P=0.591N     P=0.494      P=0.493      (e)          | 
|POLY 1.5           |     P=0.069      P=0.507      P=0.055      P=0.119     |P=0.592N     P=0.495      P=0.493      (e)          | 
|POLY 6             |     P=0.068      P=0.512      P=0.052      P=0.119     |P=0.592N     P=0.492      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.521      P=0.470      (e)          P=0.588     |(e)          P=0.487      P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.072      P=0.500      P=0.056      P=0.121     |P=0.594N     P=0.495      P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.045 *    (e)          (e)          (e)         |P=0.392N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/40.71      0/44.45     |2/48.25      0/46.83      0/46.63      0/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |2/46 (4%)    0/43 (0%)    0/43 (0%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.253N     P=0.253N     P=0.243N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.244N     P=0.245N     P=0.236N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.243N     P=0.245N     P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.113N     P=0.246N     P=0.246N     P=0.236N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.119N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.029N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  21/50 (42%)  38/49 (78%)  45/50 (90%) |15/50 (30%)  20/49 (41%)  24/49 (49%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     10/48.21     21/49.00     38/43.50     45/45.89    |15/48.27     20/48.42     24/48.96     39/49.36     | 
|POLY-3 PERCENT (g) |     20.7%        42.9%        87.4%        98.1%       |31.1%        41.3%        49.0%        79.0%        | 
|TERMINAL (d)       |     7/43 (16%)   18/46 (39%)  32/36 (89%)  40/40 (100%)|14/46 (30%)  16/43 (37%)  19/43 (44%)  35/45 (78%)  | 
|FIRST INCIDENCE    |     611          657          400          531         |723          400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.153      P=0.038 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.202      P=0.054      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.195      P=0.049 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.206      P=0.059      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.181      P=0.046 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.180      P=0.042 *    P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    16/50 (32%)  33/49 (67%)  43/50 (86%) |0/50 (0%)    4/49 (8%)    11/49 (22%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     1/47.43      16/48.59     33/44.00     43/45.86    |0/48.25      4/47.67      11/47.62     34/49.32     | 
|POLY-3 PERCENT (g) |     2.1%         32.9%        75.0%        93.8%       |0.0%         8.4%         23.1%        68.9%        | 
|TERMINAL (d)       |     1/43 (2%)    16/46 (35%)  25/36 (69%)  38/40 (95%) |0/46 (0%)    3/43 (7%)    10/43 (23%)  31/45 (69%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      400          531         |---          400          128          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.058      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.059      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.059      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.058      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.054      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.056      P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    14/49 (29%)  30/50 (60%) |1/50 (2%)    3/49 (6%)    5/49 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/47.43      4/49.73      14/43.93     30/46.89    |1/48.25      3/48.05      5/48.70      4/49.36      | 
|POLY-3 PERCENT (g) |     0.0%         8.0%         31.9%        64.0%       |2.1%         6.2%         10.3%        8.1%         | 
|TERMINAL (d)       |     0/43 (0%)    1/46 (2%)    8/36 (22%)   24/40 (60%) |1/46 (2%)    1/43 (2%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     ---          40           22           7           |729 (T)      400          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.076      P<0.001 **   P<0.001 **  |P=0.167      P=0.293      P=0.102      P=0.187      | 
|POLY 3             |     P<0.001 **   P=0.067      P<0.001 **   P<0.001 **  |P=0.167      P=0.304      P=0.104      P=0.186      | 
|POLY 1.5           |     P<0.001 **   P=0.065      P<0.001 **   P<0.001 **  |P=0.163      P=0.303      P=0.102      P=0.184      | 
|POLY 6             |     P<0.001 **   P=0.070      P<0.001 **   P<0.001 **  |P=0.171      P=0.304      P=0.106      P=0.189      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.048 *    P<0.001 **   P<0.001 **  |P=0.077      P=0.282      P=0.100      P=0.149      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.059      P<0.001 **   P<0.001 **  |P=0.157      P=0.301      P=0.098      P=0.181      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.123      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/49 (4%)    0/50 (0%)   |12/50 (24%)  14/49 (29%)  13/49 (27%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     5/47.43      2/48.59      2/41.13      0/44.45     |12/48.25     14/46.83     13/46.63     16/48.64     | 
|POLY-3 PERCENT (g) |     10.5%        4.1%         4.9%         0.0%        |24.9%        29.9%        27.9%        32.9%        | 
|TERMINAL (d)       |     5/43 (12%)   2/46 (4%)    1/36 (3%)    0/40 (0%)   |12/46 (26%)  14/43 (33%)  13/43 (30%)  16/45 (36%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      611          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030N*    P=0.191N     P=0.294N     P=0.040N*   |P=0.225      P=0.332      P=0.422      P=0.227      | 
|POLY 3             |     P=0.027N*    P=0.207N     P=0.278N     P=0.037N*   |P=0.249      P=0.376      P=0.461      P=0.260      | 
|POLY 1.5           |     P=0.026N*    P=0.212N     P=0.273N     P=0.037N*   |P=0.247      P=0.381      P=0.462      P=0.259      | 
|POLY 6             |     P=0.027N*    P=0.200N     P=0.280N     P=0.036N*   |P=0.249      P=0.365      P=0.454      P=0.257      | 
|LOGISTIC REGRESSION|     P=0.027N*    P=0.191N     P=0.268N     (e)         |P=0.225      P=0.332      P=0.422      P=0.227      | 
|COCH-ARM / FISHERS |     P=0.022N*    P=0.218N     P=0.226N     P=0.028N*   |P=0.240      P=0.387      P=0.477      P=0.252      | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |P=0.302      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/47.43      2/47.60      0/41.44      0/44.45     |1/48.25      0/46.83      0/46.63      5/48.64      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |2.1%         0.0%         0.0%         10.3%        | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    0/43 (0%)    5/45 (11%)   | 
|FIRST INCIDENCE    |     ---          726          ---          ---         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.255      (e)          (e)         |P=0.009 **   P=0.513N     P=0.513N     P=0.099      | 
|POLY 3             |     P=0.422N     P=0.238      (e)          (e)         |P=0.008 **   P=0.506N     P=0.507N     P=0.104      | 
|POLY 1.5           |     P=0.422N     P=0.236      (e)          (e)         |P=0.008 **   P=0.505N     P=0.507N     P=0.104      | 
|POLY 6             |     P=0.422N     P=0.242      (e)          (e)         |P=0.008 **   P=0.508N     P=0.508N     P=0.103      | 
|LOGISTIC REGRESSION|     P=0.425N     P=0.247      (e)          (e)         |P=0.009 **   (e)          (e)          P=0.099      | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.242      (e)          (e)         |P=0.009 **   P=0.505N     P=0.505N     P=0.102      | 
|ORDER RESTRICTED   |     P=0.261N     (e)          (e)          (e)         |P=0.003 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.70      1/47.59      0/41.44      0/44.45     |1/48.25      1/47.67      2/47.19      0/48.64      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         0.0%        |2.1%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    1/45 (2%)    0/36 (0%)    0/40 (0%)   |1/46 (2%)    0/43 (0%)    1/43 (2%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     657          729 (T)      ---          ---         |729 (T)      400          555          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.257N     P=0.751N     P=0.537N     P=0.518N    |P=0.368N     P=0.751      P=0.484      P=0.504N     | 
|POLY 3             |     P=0.248N     P=0.760      P=0.528N     P=0.514N    |P=0.364N     P=0.758      P=0.492      P=0.498N     | 
|POLY 1.5           |     P=0.247N     P=0.758      P=0.524N     P=0.514N    |P=0.365N     P=0.758      P=0.491      P=0.499N     | 
|POLY 6             |     P=0.250N     P=0.758N     P=0.532N     P=0.515N    |P=0.364N     P=0.756      P=0.492      P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.238N     P=0.756      P=0.493N     P=0.490N    |P=0.373N     P=0.780      P=0.523      (e)          | 
|COCH-ARM / FISHERS |     P=0.235N     P=0.747      P=0.500N     P=0.500N    |P=0.366N     P=0.747      P=0.492      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.265N     (e)          (e)          (e)         |P=0.266N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.70      2/47.59      1/41.85      1/44.45     |1/48.25      0/46.83      4/47.19      1/48.64      | 
|POLY-3 PERCENT (g) |     4.2%         4.2%         2.4%         2.3%        |2.1%         0.0%         8.5%         2.1%         | 
|TERMINAL (d)       |     1/43 (2%)    2/45 (4%)    0/36 (0%)    1/40 (3%)   |1/46 (2%)    0/43 (0%)    3/43 (7%)    1/45 (2%)    | 
|FIRST INCIDENCE    |     657          729 (T)      611          729 (T)     |729 (T)      ---          555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377N     P=0.677N     P=0.560N     P=0.527N    |P=0.444      P=0.513N     P=0.166      P=0.757      | 
|POLY 3             |     P=0.366N     P=0.693      P=0.545N     P=0.525N    |P=0.454      P=0.506N     P=0.172      P=0.759N     | 
|POLY 1.5           |     P=0.363N     P=0.690      P=0.540N     P=0.524N    |P=0.452      P=0.505N     P=0.172      P=0.759N     | 
|POLY 6             |     P=0.369N     P=0.690N     P=0.550N     P=0.525N    |P=0.455      P=0.508N     P=0.172      P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.688      P=0.496N     P=0.513N    |P=0.441      (e)          P=0.181      P=0.757      | 
|COCH-ARM / FISHERS |     P=0.335N     P=0.684      P=0.500N     P=0.500N    |P=0.446      P=0.505N     P=0.175      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.474N     (e)          (e)          (e)         |P=0.181      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    8/50 (16%)   14/50 (28%) |                                                    | 
|POLY-3 RATE (b)    |     1/47.84      4/48.72      8/41.53      14/45.34    |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         8.2%         19.3%        30.9%       |                                                    | 
|TERMINAL (d)       |     0/43 (0%)    3/46 (7%)    7/36 (19%)   11/40 (28%) |                                                    | 
|FIRST INCIDENCE    |     611          696          706          531         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.203      P=0.010 *    P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.185      P=0.008 **   P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.182      P=0.009 **   P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.189      P=0.008 **   P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.177      P=0.011 *    P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.181      P=0.015 *    P<0.001 **  |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/47 (15%)   5/46 (11%)   9/46 (20%)   8/47 (17%)  |5/50 (10%)   2/48 (4%)    7/48 (15%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/46.48      5/45.73      9/44.18      8/46.59     |5/49.71      2/46.22      7/47.36      3/49.35      | 
|POLY-3 PERCENT (g) |     15.1%        10.9%        20.4%        17.2%       |10.1%        4.3%         14.8%        6.1%         | 
|TERMINAL (d)       |     4/42 (10%)   3/43 (7%)    0/34 (0%)    1/38 (3%)   |2/46 (4%)    1/42 (2%)    3/42 (7%)    0/45 (0%)    | 
|FIRST INCIDENCE    |     24           696          7            7           |402          620          128          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.279      P=0.362N     P=0.307      P=0.453     |P=0.447N     P=0.250N     P=0.345      P=0.363N     | 
|POLY 3             |     P=0.332      P=0.391N     P=0.350      P=0.502     |P=0.439N     P=0.248N     P=0.346      P=0.361N     | 
|POLY 1.5           |     P=0.333      P=0.393N     P=0.358      P=0.501     |P=0.441N     P=0.243N     P=0.349      P=0.360N     | 
|POLY 6             |     P=0.332      P=0.388N     P=0.346      P=0.503     |P=0.436N     P=0.253N     P=0.343      P=0.362N     | 
|LOGISTIC REGRESSION|     P=0.317N     P=0.615      P=0.265N     P=0.484N    |P=0.530N     P=0.207N     P=0.393      P=0.421N     | 
|COCH-ARM / FISHERS |     P=0.333      P=0.395N     P=0.374      P=0.500     |P=0.443N     P=0.235N     P=0.351      P=0.357N     | 
|ORDER RESTRICTED   |     P=0.357      (e)          (e)          (e)         |P=0.380N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/46 (2%)    0/46 (0%)    0/47 (0%)   |0/50 (0%)    0/48 (0%)    0/48 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/44.84      1/45.59      0/38.11      0/42.07     |0/48.25      0/45.83      0/45.63      4/48.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         8.2%         | 
|TERMINAL (d)       |     0/42 (0%)    1/43 (2%)    0/34 (0%)    0/38 (0%)   |0/46 (0%)    0/42 (0%)    0/42 (0%)    3/45 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          727          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.587N     P=0.505      (e)          (e)         |P=0.004 **   (e)          (e)          P=0.063      | 
|POLY 3             |     P=0.577N     P=0.503      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 1.5           |     P=0.576N     P=0.502      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 6             |     P=0.577N     P=0.506      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.061      | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.004 **   (e)          (e)          P=0.063      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.003 **   (e)          (e)          P=0.059      | 
|ORDER RESTRICTED   |     P=0.395N     (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  2/50 (4%)    3/50 (6%)    4/50 (8%)   |15/49 (31%)  14/48 (29%)  12/48 (25%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     10/47.66     2/48.59      3/41.44      4/44.45     |15/47.25     14/46.22     12/46.89     9/48.64      | 
|POLY-3 PERCENT (g) |     21.0%        4.1%         7.2%         9.0%        |31.8%        30.3%        25.6%        18.5%        | 
|TERMINAL (d)       |     9/43 (21%)   2/46 (4%)    3/36 (8%)    4/40 (10%)  |15/45 (33%)  13/42 (31%)  11/43 (26%)  9/45 (20%)   | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      729 (T)     |729 (T)      620          128          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126N     P=0.012N*    P=0.074N     P=0.098N    |P=0.077N     P=0.586N     P=0.376N     P=0.118N     | 
|POLY 3             |     P=0.109N     P=0.012N*    P=0.062N     P=0.094N    |P=0.068N     P=0.528N     P=0.334N     P=0.103N     | 
|POLY 1.5           |     P=0.106N     P=0.013N*    P=0.057N     P=0.094N    |P=0.069N     P=0.527N     P=0.337N     P=0.104N     | 
|POLY 6             |     P=0.113N     P=0.011N*    P=0.066N     P=0.094N    |P=0.067N     P=0.533N     P=0.334N     P=0.103N     | 
|LOGISTIC REGRESSION|     P=0.119N     P=0.014N*    P=0.065N     P=0.093N    |P=0.073N     P=0.546N     P=0.338N     P=0.118N     | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.014N*    P=0.036N*    P=0.074N    |P=0.073N     P=0.527N     P=0.349N     P=0.109N     | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.105N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/50 (6%)    33/50 (66%) |1/49 (2%)    1/48 (2%)    1/48 (2%)    9/50 (18%)   | 
|POLY-3 RATE (b)    |     0/47.43      2/48.59      3/41.44      33/44.56    |1/47.25      1/45.83      1/45.89      9/48.67      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         7.2%         74.1%       |2.1%         2.2%         2.2%         18.5%        | 
|TERMINAL (d)       |     0/43 (0%)    2/46 (4%)    3/36 (8%)    32/40 (80%) |1/45 (2%)    1/42 (2%)    1/43 (2%)    8/45 (18%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      701         |729 (T)      729 (T)      729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.253      P=0.092      P<0.001 **  |P<0.001 **   P=0.746      P=0.751      P=0.010 *    | 
|POLY 3             |     P<0.001 **   P=0.243      P=0.097      P<0.001 **  |P<0.001 **   P=0.754      P=0.754      P=0.009 **   | 
|POLY 1.5           |     P<0.001 **   P=0.240      P=0.099      P<0.001 **  |P<0.001 **   P=0.755      P=0.754      P=0.009 **   | 
|POLY 6             |     P<0.001 **   P=0.247      P=0.094      P<0.001 **  |P<0.001 **   P=0.752      P=0.754      P=0.009 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.253      P=0.092      P<0.001 **  |P<0.001 **   P=0.746      P=0.751      P=0.011 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.247      P=0.121      P<0.001 **  |P<0.001 **   P=0.747      P=0.747      P=0.009 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   25/50 (50%) |6/49 (12%)   3/48 (6%)    23/48 (48%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     1/47.57      0/48.59      6/42.69      25/45.00    |6/47.25      3/45.83      23/46.03     46/48.68     | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         14.1%        55.6%       |12.7%        6.6%         50.0%        94.5%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    3/36 (8%)    22/40 (55%) |6/45 (13%)   3/42 (7%)    22/43 (51%)  44/45 (98%)  | 
|FIRST INCIDENCE    |     694          ---          531          654         |729 (T)      729 (T)      693          720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.483N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.277N     P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.496N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.258N     P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.498N     P=0.041 *    P<0.001 **  |P<0.001 **   P=0.255N     P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.493N     P=0.040 *    P<0.001 **  |P<0.001 **   P=0.262N     P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.502N     P=0.054      P<0.001 **  |P<0.001 **   P=0.277N     P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.056      P<0.001 **  |P<0.001 **   P=0.254N     P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |16/50 (32%)  16/49 (33%)  6/49 (12%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     0/47.43      0/48.59      0/41.44      0/44.45     |16/48.25     16/46.87     6/46.63      11/48.67     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |33.2%        34.1%        12.9%        22.6%        | 
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/36 (0%)    0/40 (0%)   |16/46 (35%)  15/43 (35%)  6/43 (14%)   10/45 (22%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      720          729 (T)      720          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.083N     P=0.493      P=0.022N*    P=0.202N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.070N     P=0.546      P=0.016N*    P=0.176N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.072N     P=0.552      P=0.016N*    P=0.177N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.069N     P=0.535      P=0.017N*    P=0.176N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.072N     P=0.498      P=0.022N*    P=0.182N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.077N     P=0.558      P=0.016N*    P=0.184N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.049N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    2/49 (4%)    2/49 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |3/48.25      2/46.83      2/46.63      6/48.64      | 
|POLY-3 PERCENT (g) |                                                        |6.2%         4.3%         4.3%         12.3%        | 
|TERMINAL (d)       |                                                        |3/46 (7%)    2/43 (5%)    2/43 (5%)    6/45 (13%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.113      P=0.531N     P=0.531N     P=0.232      | 
|POLY 3             |                                                        |P=0.117      P=0.514N     P=0.515N     P=0.247      | 
|POLY 1.5           |                                                        |P=0.117      P=0.511N     P=0.515N     P=0.246      | 
|POLY 6             |                                                        |P=0.117      P=0.518N     P=0.518N     P=0.246      | 
|LOGISTIC REGRESSION|                                                        |P=0.113      P=0.531N     P=0.531N     P=0.232      | 
|COCH-ARM / FISHERS |                                                        |P=0.115      P=0.510N     P=0.510N     P=0.243      | 
|ORDER RESTRICTED   |                                                        |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   2/49 (4%)    9/49 (18%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |6/48.25      2/46.83      9/47.19      4/48.64      | 
|POLY-3 PERCENT (g) |                                                        |12.4%        4.3%         19.1%        8.2%         | 
|TERMINAL (d)       |                                                        |6/46 (13%)   2/43 (5%)    8/43 (19%)   4/45 (9%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      555          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.520N     P=0.157N     P=0.246      P=0.383N     | 
|POLY 3             |                                                        |P=0.502N     P=0.143N     P=0.272      P=0.365N     | 
|POLY 1.5           |                                                        |P=0.505N     P=0.142N     P=0.270      P=0.366N     | 
|POLY 6             |                                                        |P=0.500N     P=0.146N     P=0.272      P=0.366N     | 
|LOGISTIC REGRESSION|                                                        |P=0.508N     P=0.157N     P=0.268      P=0.383N     | 
|COCH-ARM / FISHERS |                                                        |P=0.512N     P=0.141N     P=0.274      P=0.370N     | 
|ORDER RESTRICTED   |                                                        |P=0.326      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   0/49 (0%)    5/49 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |5/48.25      0/46.83      5/46.63      1/48.64      | 
|POLY-3 PERCENT (g) |                                                        |10.4%        0.0%         10.7%        2.1%         | 
|TERMINAL (d)       |                                                        |5/46 (11%)   0/43 (0%)    5/43 (12%)   1/45 (2%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.191N     P=0.040N*    P=0.588      P=0.109N     | 
|POLY 3             |                                                        |P=0.178N     P=0.033N*    P=0.608      P=0.100N     | 
|POLY 1.5           |                                                        |P=0.179N     P=0.033N*    P=0.609      P=0.100N     | 
|POLY 6             |                                                        |P=0.176N     P=0.034N*    P=0.605      P=0.100N     | 
|LOGISTIC REGRESSION|                                                        |P=0.191N     (e)          P=0.588      P=0.109N     | 
|COCH-ARM / FISHERS |                                                        |P=0.186N     P=0.030N*    P=0.617      P=0.102N     | 
|ORDER RESTRICTED   |                                                        |P=0.052N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/06/04                           EXPERIMENT: 92012 TEST: 06                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    2-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         625 PPM      1250 PPM     2500 PPM    |0PPM         625 PPM      1250 PPM     2500 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |48/50 (96%)  47/49 (96%)  46/49 (94%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |                                                        |48/49.39     47/48.80     46/47.74     45/49.56     | 
|POLY-3 PERCENT (g) |                                                        |97.2%        96.3%        96.4%        90.8%        | 
|TERMINAL (d)       |                                                        |45/46 (98%)  43/43 (100%) 42/43 (98%)  42/45 (93%)  | 
|FIRST INCIDENCE    |                                                        |402          400          555          517          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.226N     P=0.348      P=0.489      P=0.369N     | 
|POLY 3             |                                                        |P=0.084N     P=0.634N     P=0.642N     P=0.171N     | 
|POLY 1.5           |                                                        |P=0.095N     P=0.653N     P=0.640N     P=0.186N     | 
|POLY 6             |                                                        |P=0.076N     P=0.628N     P=0.646N     P=0.164N     | 
|LOGISTIC REGRESSION|                                                        |P=0.081N     P=0.694N     P=0.585N     P=0.171N     | 
|COCH-ARM / FISHERS |                                                        |P=0.116N     P=0.684N     P=0.490N     P=0.218N     | 
|ORDER RESTRICTED   |                                                        |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).