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TDMS Study 93005-03 Pathology Tables

NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03
Route: DOSED FEED                                                                                                 Time: 14:26:54




       Facility:  National Center for Toxicological Research

       Chemical CAS #:  569-64-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1


NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                      X                                   X               |             
      Basophilic Focus, Multiple           |    X                                               X  X        X     X  X|             
      Developmental Malformation           |                   X                                   X     X            |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  2                                                                     |             
      Hepatodiaphragmatic Nodule           |                                                             X  X         |             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
      Inflammation, Focal, Granulomatous   |                                     2                 2        1     1  2|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Vacuolization Cytoplasmic            |                2              3     1                                    |             
      Bile Duct, Hyperplasia               |                                  2                                   2  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +                    +                    +  +  +              +   |             
      Fat, Necrosis                        |                                                 3  2  3              2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1        1     1           2     1  2                 1           1|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2           2  1                 1           1              2      |             
      Atrium, Thrombosis                   |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                 2  1           1         |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic            |                                              1  1           1            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +|             
      Hyperplasia, Focal                   |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                      3                        |             
      Pars Distalis, Cyst                  |    1                             2  1                       1            |             
      Pars Distalis, Hyperplasia           |                                  2                                       |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      2           2                                1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
      Inflammation                         |    2        1     2  2           2     2  3                       2      |             
      Duct, Dilatation                     |       3                          3                 3                     |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                    3  3  2        2  3     2  2     3            |             
      Cyst                                 |                            2                 2  3                    2   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              2                           |             
      Cervix, Hypertrophy                  |                                              3                           |             
      Cervix, Serosa, Cyst                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      2              1     2           3     2  2         |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               2        2  2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Myelostromal Proliferation           |                                                                          |             
      Myeloid Cell, Hyperplasia            |    2                                                     2     2  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +              +  +              +        +           +         |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                    2                     |             
      Mediastinal, Hemorrhage              |                                                                2         |             
      Mediastinal, Hyperplasia, Lymphoid   |                         2                                                |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                         2                                                |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                  2  2                 2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  3        4     3              2                                    |             
      Hyperplasia, Focal                   |                                                                          |             
      Pigmentation                         |                               3                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Cyst                                 |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                               3                             3           2|             
      Hyperplasia                          |             3     3  1  3  2  3  2  1  2  3  2  2  2  2     1  2  2  2  1|             
      Duct, Dilatation                     |    1                    3     2        2                 2  2     2      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                   3      |             
      Femur, Osteopetrosis                 |                3                          3                 2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
      Sternum, Osteopetrosis               |                3                          3                 2            |             
      Turbinate, Osteopetrosis             |                3                          3                              |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           1                              |             
      Hypothalamus, Compression            |                         2     1                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Nasolacrimal Duct, Inflammation      |          3           2  2  2     2  1        2  2           1        2  3|             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                             2            |             
      Olfactory Epithelium, Respiratory    |                                                                          |             
          Epithelium, Cytoplasmic          |                                                                          |             
          Alteration                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                      1                                2     1            |             
      Bilateral, Cataract                  |                                                                          |             
      Bilateral, Retina, Degeneration      |                               2  3              3  3  4  3     3  2     2|             
      Retina, Autolysis                    |                                                                          |             
      Retina, Degeneration                 |          2                 1                                3            |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2        2  2     1  2  2     1  1  1  1        2  2  1  2  1  1  1  1|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                            +  +  +  +  +              +        +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia                           |                            2  2  2  2  2              2        2  2  2   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2  3  2  2  2  2  3  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2   |             
      Nephropathy                          |             1  2     1  2     3  1  1     1  1  2  1  1  1  1  1  3  1  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |       2                                                                  |      1  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           | X  X     X  X  X        X  X  X  X  X                 X     X     X      |     19     |
      Developmental Malformation           |                      X                                                   |      4     |
      Eosinophilic Focus                   |                            X  X                          X               |      3     |
      Eosinophilic Focus, Multiple         |                                     X                          X         |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      3     |
      Infiltration Cellular, Lymphocyte    |                                                                   1      |      2  1.0|
      Inflammation, Focal, Granulomatous   | 2  1        1  2        2     1  2  2           1     1  2  2  1         |     18  1.6|
      Inflammation, Focal, Suppurative     |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic            |                                                 3                        |      4  2.3|
      Bile Duct, Hyperplasia               |          1  1        2                       1  2     1           1      |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +           +           +                                             |   9        |
      Fat, Necrosis                        |    3           2           3                                             |      7  2.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Atrophy                      |       1  1        1                 1              1                     |     13  1.2|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |       2  1  1                 2  1                                1      |     13  1.5|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Accessory Adrenal Cortical Nodule    |                                              2                           |      1  2.0|
      Angiectasis                          |          1  2                 1     1  1  1                    2         |     10  1.3|
      Hypertrophy, Focal                   |                                                    2                     |      1  2.0|
      Vacuolization Cytoplasmic            |                   2                          1  2                        |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |       3                                         2  2                     |      5  2.4|
      Pars Distalis, Cyst                  |                         1  1  2           3                              |      8  1.5|
      Pars Distalis, Hyperplasia           | 3                                2     2        1                        |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      C-Cell, Hyperplasia                  |    1        1     1           2                                   1      |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |          3           2           2                                2      |      5  2.2|
      Inflammation                         |    2        3     2  4     2  2     2     2     2  2     2  2  2         |     21  2.1|
      Duct, Dilatation                     | 3                                3     2                                 |      6  2.8|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              | 2  2  2     3     2  3                 2                 3     2         |     18  2.4|
      Cyst                                 | 3                                                                        |      5  2.4|
      Infiltration Cellular, Lymphocyte    |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Cervix, Serosa, Cyst                 |                            3                                             |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Myelostromal Proliferation           |                                           2                              |      1  2.0|
      Myeloid Cell, Hyperplasia            |                            2                                             |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  +                                +               |  10        |
      Deep Cervical, Hemorrhage            |                         2                                                |      1  2.0|
      Deep Cervical, Hyperplasia, Lymphoid |                         2                                                |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |                      2                                                   |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                         2                                                |      2  2.0|
      Pancreatic, Hemorrhage               |                         2                                                |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Ectasia                       |                   3                                                      |      1  3.0|
      Renal, Hemorrhage                    |                   2     2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                   3              2                                       |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia, Lymphoid                |                                                    2                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      6  2.8|
      Hyperplasia, Focal                   |                         4                                                |      1  4.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  40        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |  46        |
      Galactocele                          |                      2                                                   |      4  2.5|
      Hyperplasia                          |             3  2     2           2        3  2     3  2           1      |     28  2.1|
      Duct, Dilatation                     |    1        3     2  2                                2                  |     12  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperkeratosis                       |                      2                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  3.0|
      Femur, Osteopetrosis                 |          2        2                                      4     3  2      |      8  2.6|
      Sternum, Osteopetrosis               |          2        2                                      4     3  2      |      8  2.6|
      Turbinate, Osteopetrosis             |                   2                    2                 4     3  2      |      7  2.7|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hypothalamus, Compression            |                   2  2                                         2         |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic, Focal         |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                       2                  |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                1         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Nasolacrimal Duct, Inflammation      | 1     1  1  2     2                 1                    1  1            |     19  1.7|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                3         |      2  2.5|
      Olfactory Epithelium, Respiratory    |                                                                          |            |
          Epithelium, Cytoplasmic          |                                                                          |            |
          Alteration                       |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cataract                             |                2     2           1                          1            |      7  1.4|
      Bilateral, Cataract                  |                         1                                                |      1  1.0|
      Bilateral, Retina, Degeneration      |    3     3     3                                      2                  |     13  2.8|
      Retina, Autolysis                    |                      X                                                   |      1     |
      Retina, Degeneration                 |       1     3                                            3  2     2      |      8  2.1|
      Sclera, Metaplasia, Osseous          |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                1                                                         |      1  1.0|
      Infiltration Cellular, Lymphocyte    | 2  1  2  2     2  1     1  1        1  2     1  2     1  2  1     1      |     34  1.4|
      Inflammation                         |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          | +  +  +     +  +  +           +  +  +                                    |  18        |
      Infiltration Cellular, Lymphocyte    |                2  1                                                      |      2  1.5|
      Metaplasia                           | 3  2  1     2  2  2           2  2  2                                    |     18  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |                   2  2  2  2                          2  2  2  2  2      |     33  2.0|
      Nephropathy                          | 1  1  1  1  2  2  1  2     1  1  1  2  1  1  2  1  1  1     1  2  3      |     39  1.4|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    |                                                                   1      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                                        X      |             
      Basophilic Focus, Multiple           |       X                                                                 X|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                             2            |             
      Developmental Malformation           |             X                                                            |             
      Eosinophilic Focus                   |                   X        X     X              X                        |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Hepatodiaphragmatic Nodule           |    X     X     X           X                                             |             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
      Inflammation, Focal, Granulomatous   |          2        2                                                  1   |             
      Inflammation, Focal, Suppurative     |                                                                         2|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                     4        3                           |             
      Bile Duct, Hyperplasia               |             2                                                  3  1     1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                 +        +  +                                 |             
      Fat, Necrosis                        |          3                 3           3                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Atrophy                      |                      1        3        1        2           1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2           1            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
      Inflammation                         |    3                             1                                       |             
      Necrosis                             |                                     2                                    |             
      Epithelium, Hyperplasia              |                            2                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1        1              1     2  1        1  1        1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        1                 2               |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                   2      |             
      Vacuolization Cytoplasmic            |    2                                         2        1                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |                1                                      2                  |             
      Pars Distalis, Cyst                  |                                        1              1                 2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  1                                       |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                       2               |             
      Inflammation                         |       1        2  2  2        3  3     2     2  2  2     3              2|             
      Duct, Dilatation                     |                3              3              3     3                 2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  2           2  3              2  2  2     2        2  2   |             
      Cyst                                 |                               2                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hypertrophy                  |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                         3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                      2         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                       +                          +           +         |             
      Pigmentation                         |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
          Proliferation                    |                                                    2                     |             
      Lumbar, Hemorrhage                   |                                                    2                     |             
      Mediastinal, Hemorrhage              |                                                    2                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 2                        |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Infiltration Cellular, Plasma Cell   |                                              2                       2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
      Infiltration Cellular, Plasma Cell   |                3                                                         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |    3        3                                                            |             
      Capsule, Hemorrhage                  |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Ectopic Parathyroid Gland            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    3  3                                      3                           |             
      Hyperplasia                          | 3           2     2  1     2     4     2  1  1  2  2  1     2  2  2  2  1|             
      Inflammation                         |                                                                          |             
      Duct, Dilatation                     |    2              2     2  3                       2  2  2  2  2  2  2   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      3   |             
      Epidermis, Hyperplasia               |                                                                          |             
      Epidermis, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                               2                                          |             
      Femur, Osteopetrosis                 |                            3                                         2   |             
      Sternum, Fibrous Osteodystrophy      |                               2                                          |             
      Sternum, Osteopetrosis               |                            3                                         2   |             
      Turbinate, Osteopetrosis             |                            3                                         2   |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Hypothalamus, Compression            |    3        2     3        2     2              1  1        2            |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Focal         |                   2                                                      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                             2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |    1                                         1     2     2              2|             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|             
                                           | 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 PPM                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|             
                                           | 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Cataract                             |                      2                                                   |             
      Bilateral, Cataract                  |                                                          2               |             
      Bilateral, Retina, Degeneration      |                                  1  2        3  3           2  2  2  2  2|             
      Retina, Autolysis                    | X                    X                                   X               |             
      Retina, Degeneration                 |                            2           3                                 |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1  1        1  1  1  1  1  1  1     1  1     2  1  1  1  1  3     1|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                         +                    +  +           +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                      1   |             
      Metaplasia                           |                         2                    2  1           2  2  2  2   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2     2  2  2|             
      Nephropathy                          |    2     2  2     1  1     2     2  1        2  2  2  1  1  1     1  1  1|             
      Pelvis, Inflammation                 |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Dilatation                           |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |                                                 X                        |      3     |
      Basophilic Focus, Multiple           | X  X  X  X              X     X  X        X        X  X        X  X      |     14     |
      Clear Cell Focus                     |       X  X                                                               |      2     |
      Cyst                                 |                                                                          |      1  2.0|
      Developmental Malformation           |    X  X  X     X           X     X                                       |      7     |
      Eosinophilic Focus                   |    X                    X     X           X     X                        |      9     |
      Eosinophilic Focus, Multiple         |                                                                X         |      1     |
      Hematopoietic Cell Proliferation     |                                     1                          1         |      3  1.0|
      Hepatodiaphragmatic Nodule           |             X              X                                             |      6     |
      Infiltration Cellular, Lymphocyte    | 1                       1                                                |      3  1.3|
      Inflammation, Focal, Granulomatous   |    2  1  2           2     2                    1  1  1  2  1  2  1      |     15  1.5|
      Inflammation, Focal, Suppurative     |                   3                                                      |      2  2.5|
      Mixed Cell Focus                     |                X     X                                                   |      2     |
      Necrosis                             |    1              2                                                      |      2  1.5|
      Vacuolization Cytoplasmic            |             2                    2                                       |      4  2.8|
      Bile Duct, Hyperplasia               | 2                       1     2              2        1  2               |     10  1.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |                                              +                           |   5        |
      Fat, Necrosis                        |                                              3                           |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Acinus, Atrophy                      |    3     2              2        2  1        1  1        2  1            |     14  1.6|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       | 1  2                    1     1  1  1              1  1  1     1  2      |     22  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |       1  1  1        1        2                       2  1     2  2      |     11  1.5|
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
      Hypertrophy, Focal                   |    2     1                                               1               |      4  1.5|
      Vacuolization Cytoplasmic            |                                                          2     2         |      5  1.8|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                 2        3               |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                                                                          |      2  1.5|
      Pars Distalis, Cyst                  |                1                          2                              |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      C-Cell, Hyperplasia                  |          1     1     2                                            2      |      5  1.4|
      Follicle, Cyst                       |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                         2     2                                          |      4  2.0|
      Inflammation                         | 3  2  2  3  2  3  2     2  2  2     2  2     2  3  3  3  2  1            |     30  2.2|
      Duct, Dilatation                     |                                                                          |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                               2              2              2     2      |     14  2.1|
      Cyst                                 |             3           2                    2                           |      4  2.3|
      Interstitial Cell, Hyperplasia       | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2                       1                                                |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                2                                                         |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                              1                           |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                +                             +                 +         |   7        |
      Pigmentation                         |                                              2                           |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                     2                             2      |      3  2.0|
      Infiltration Cellular, Plasma Cell   |    2                                         2                 2         |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |    2                                                           2         |      2  2.0|
      Pigmentation                         |                                                                          |      2  3.0|
      Capsule, Hemorrhage                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |  42        |
      Ectopic Parathyroid Gland            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Galactocele                          | 3                    3              3  3                          3      |      8  3.0|
      Hyperplasia                          |    2     2  2  3  2  1     1  1  2  3  2     3  1     1  2  1            |     33  1.8|
      Inflammation                         |                                     3                                    |      1  3.0|
      Duct, Dilatation                     |    2  1  2     2           2  2        2     2  1        2  1            |     22  1.9|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                2                                                         |      1  2.0|
      Epidermis, Necrosis                  |                2                                         2               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  2.0|
      Femur, Osteopetrosis                 |                                              1                           |      3  2.0|
      Sternum, Fibrous Osteodystrophy      |                                                                          |      1  2.0|
      Sternum, Osteopetrosis               |                                              1                           |      3  2.0|
      Turbinate, Osteopetrosis             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hypothalamus, Compression            |                   2              3  2  2     2              1            |     14  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic, Diffuse       |                   2                                                      |      1  2.0|
      Inflammation, Chronic, Focal         |                      1  2                                                |      3  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nasolacrimal Duct, Inflammation      |    2  1                                2        2           1            |     10  1.6|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                    2  3        2         |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             |                   1                                                      |      2  1.5|
      Bilateral, Cataract                  |                                                                          |      1  2.0|
      Bilateral, Retina, Degeneration      | 2        2  2                                2           2               |     14  2.1|
      Retina, Autolysis                    |                   X                                                      |      4     |
      Retina, Degeneration                 |    2  2                             1  2                    2  2         |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    | 1  2     2  2  1     1  1  1  1  1     1  2  1  2  1     1  1  2  1      |     37  1.2|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          | +  +     +  +  +  +                    +                                 |  14        |
      Infiltration Cellular, Lymphocyte    |          1                                                               |      2  1.0|
      Metaplasia                           | 2  3     2  2  2  1                    2                                 |     14  1.9|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    100 PPM                                | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9|     |      L     |
                                           | 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Metaplasia, Squamous                 |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       | 2              2        2                    2  2  2     2               |     31  2.0|
      Nephropathy                          | 3  2  1  1  3     3  2  1  1  3  1     2  1  1  2  1  2  1  2  1  1      |     38  1.6|
      Pelvis, Inflammation                 |                                     1                                    |      1  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                     1                                    |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                     X                       X            |             
      Basophilic Focus, Multiple           | X     X  X                                      X     X        X  X  X   |             
      Clear Cell Focus, Multiple           |                                                       X                  |             
      Degeneration, Cystic                 |                                                    2                     |             
      Developmental Malformation           |                         X                                                |             
      Eosinophilic Focus                   |                                     X                                    |             
      Eosinophilic Focus, Multiple         |          X  X     X                             X  X  X        X        X|             
      Hematopoietic Cell Proliferation     |    1              1                                   1                  |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Infiltration Cellular, Lymphocyte    |                                              1                          1|             
      Inflammation, Focal, Granulomatous   | 1           2              2              2     2  2           2  1  1   |             
      Necrosis                             |       2                                                        1         |             
      Vacuolization Cytoplasmic            |                            3                                             |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |       2                 1                                2  1            |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                          +                                             |             
      Fat, Necrosis                        | 3                          2                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                1         |             
      Acinus, Atrophy                      |    1              2                    2              1           2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                1         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      2                                                   |             
      Inflammation                         |                            3                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2                 1                          1        1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                2         |             
      Angiectasis                          |             2     2        1                 1  2     1  1  2            |             
      Hyperplasia, Focal                   |                                                                      2   |             
      Hypertrophy, Focal                   |                                                                2         |             
      Vacuolization Cytoplasmic            |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3              1                        |             
      Pars Distalis, Cyst                  |    2                                                                 2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Hyperplasia           |    2     2                                      3     2              2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1  3     2        1                       2  1  1     1      |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                               2                                   2      |             
      Inflammation                         |    2        2     2  2           1  2  3  1  2  2  3  3  2  3  3  2      |             
      Duct, Dilatation                     |       2        2  2                    3                                 |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2        2  4     2           4                              |             
      Cyst                                 | 2                    2                             2                 2   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Cervix, Hypertrophy                  |                                        2                                 |             
      Endometrium, Hyperplasia, Cystic     |                                           2        2           1         |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2     2  2     2  2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Myelofibrosis                        |                                  2                                       |             
      Myeloid Cell, Hyperplasia            | 3                                               2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +        +                             +                    +      |             
      Mediastinal, Hemorrhage              |       3                                      2                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hemorrhage                    |                                                                   1      |             
      Renal, Hyperplasia, Lymphoid         |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Infiltration Cellular, Plasma Cell   |                                     2  3  2        2     2               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    2                     |             
      Hemorrhage                           |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3     2                                                                  |             
      Pigmentation                         |                   3                       3                              |             
      Thrombosis                           |                               3                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         2           3                                    |             
      Hyperplasia                          |       3  2  2  2  2  2  2  2  2  3     3  1     2        2  1     1  2  2|             
      Duct, Dilatation                     |             2  2  2  3  2  2           2  2     1     1  2              2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                      2   |             
      Sternum, Osteopetrosis               |                                                                      2   |             
      Turbinate, Osteopetrosis             |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |       2     2  2        3  3        2  1  2                              |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Chronic, Focal         |                                                          2        2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Suppurative            |                                                                   3      |             
      Nasolacrimal Duct, Inflammation      |                      1                          2  3                 1  2|             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                          2  2            |             
      Olfactory Epithelium, Respiratory    |                                                                          |             
          Epithelium, Cytoplasmic          |                                                                          |             
          Alteration                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                 1      |             
      Epithelium, Hyperplasia              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  2                                       |             
      Phthisis Bulbi                       |                                  X              X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Bilateral, Cataract                  |                                                                2         |             
      Bilateral, Retina, Degeneration      |    2     2  3     2  2  2           2                 3     2  2  2  3  2|             
      Retina, Degeneration                 |                               2  2           2  2  2     2               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2     1     2  1     1     1        2     1  1  2  1  2  1  1  1        1|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |       +     +     +  +     +  +  +              +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                       1           2      |             
      Metaplasia                           |       2     2     2  2     2  2  2              2     2  2  2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       | 2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2|             
      Nephropathy                          |       2  1     2  2  1  1  1  2  2  2  1  1  2  1  1  1  1  1  2  2  1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           |       X  X  X  X                                   X  X  1  X  X  X      |     18  1.0|
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Developmental Malformation           |                      X                                                   |      2     |
      Eosinophilic Focus                   |                      X              X                                    |      3     |
      Eosinophilic Focus, Multiple         |                                        X                       X         |     10     |
      Hematopoietic Cell Proliferation     |                                  1                                       |      4  1.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      2     |
      Infiltration Cellular, Lymphocyte    |       1                                                                  |      3  1.0|
      Inflammation, Focal, Granulomatous   | 1        2     1        1     1     2  2  2  1  2     1  1     1  1      |     23  1.5|
      Necrosis                             |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Bile Duct, Cyst                      |             2                                                            |      1  2.0|
      Bile Duct, Hyperplasia               |    3  1     1                 1                                   1      |      9  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Acinus, Atrophy                      |       1        1     1     1           1     2                    1      |     12  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       | 1  1  1                 1  1           1  1     1  1  1  1        1      |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Angiectasis                          |             2  1        1              1  1     2  2           2  2      |     17  1.5|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                           1                              |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis                          |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |       1  3  2        1  2                          2        2            |      9  1.9|
      Pars Distalis, Hyperplasia           |       2  2  2           2                          2        3            |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  47        |
      C-Cell, Hyperplasia                  | 1     1     1                                                            |     11  1.4|
      Follicle, Cyst                       |                            3                                             |      1  3.0|
      Follicular Cell, Hyperplasia         |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation                         | 2  2     2                    2     2        3        2                  |     23  2.2|
      Duct, Dilatation                     |                3                    3              3                     |      7  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              | 2  2        2                       2        3              2            |     11  2.5|
      Cyst                                 |                                              2        2        2         |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Thrombosis                           |                3                                                         |      1  3.0|
      Cervix, Hypertrophy                  |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2                    2  1  3                 2  2     2        1         |     11  1.8|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                         1        3                                       |      2  2.0|
      Myelofibrosis                        | 2                                                                        |      2  2.0|
      Myeloid Cell, Hyperplasia            |                                                    2     1  2            |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +     +           +                                 |   7        |
      Mediastinal, Hemorrhage              |                                        2                                 |      3  2.3|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                      3                                                   |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |             2                                                            |      2  2.5|
      Hyperplasia, Lymphoid                |                                                 2                        |      2  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |                      3        2  2                       2  2            |      7  2.3|
      Pigmentation                         |                                                                          |      2  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Galactocele                          |                                                                          |      2  2.5|
      Hyperplasia                          | 2  1     1        2  2     3  2  2     1     2                    2      |     29  1.9|
      Duct, Dilatation                     |    2     2           2        2              2           2               |     18  1.9|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Osteopetrosis                 |                      3           3                                       |      3  2.7|
      Sternum, Osteopetrosis               |                      3           3                                       |      3  2.7|
      Turbinate, Osteopetrosis             |                      3           3                                       |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hypothalamus, Compression            | 3                                            3                           |     10  2.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                     1                    2               |      4  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  4                       2               |      2  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation      |          1  2     2                 2  1  2                              |     11  1.7|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                              2  2     1        2         |      6  1.8|
      Olfactory Epithelium, Respiratory    |                                                                          |            |
          Epithelium, Cytoplasmic          |                                                                          |            |
          Alteration                       |                                  3                                3      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                2         |      3  1.7|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Phthisis Bulbi                       |                                                                          |      2     |
      Bilateral, Cataract                  |                      2                                                   |      2  2.0|
      Bilateral, Retina, Degeneration      |                      2                          2  2  3  2  2  2         |     20  2.2|
      Retina, Degeneration                 |          2                    1        2                                 |      9  1.9|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    | 1     1  1  1  1  1     2  1  1  1  1     1  2  2  1  1  2  1  2  1      |     36  1.3|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |  15        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
      Metaplasia                           |                                                                          |     15  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|     |      A     |
    300 PPM                                | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0|     |      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hydronephrosis                       |                                                                   2      |      1  2.0|
      Mineralization                       |       2              2  2  2     2                             1  1      |     30  1.9|
      Nephropathy                          | 2  1  1  1  1  1  1  1  1  2  2  2  3  1  2  3        1  1     1  1      |     41  1.4|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    |                                           1                              |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          3                                                               |             
      Foreign Body                         |                                              X                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X                             X              X  X      |             
      Basophilic Focus, Multiple           |                                     X                                   X|             
      Developmental Malformation           |                X                                      X     X  X         |             
      Eosinophilic Focus                   |                                  X     X                 X           X   |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2     3     1                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1           1                                         1      |             
      Inflammation, Focal, Granulomatous   |                2  1                                   2  2  1        1  1|             
      Mixed Cell Focus, Multiple           |                                                                   X      |             
      Necrosis                             |                                                    1                     |             
      Vacuolization Cytoplasmic            | 2                             3                                         2|             
      Bile Duct, Hyperplasia               |                                                                   1  1  2|             
      Centrilobular, Necrosis              |       3                       2              2           3               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                               +              +                           |             
      Fat, Necrosis                        |                                              3                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                   1                                                      |             
      Inflammation                         | 2                                                                        |             
      Acinus, Atrophy                      |                         2                          1           1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2                 1  1        1  1                    2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1     2     3        2  1  2   |             
      Atrophy                              |                                                             2           2|             
      Hematopoietic Cell Proliferation     |                            1                                             |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hypertrophy, Focal                   |                                           1                              |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Vacuolization Cytoplasmic            |                                                          2               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  +  M  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |             2  1                 2  1     2                 2           3|             
      Pars Distalis, Hyperplasia           |             2  1                 2  1                                    |             
      Pars Intermedia, Cyst                |                            2                                             |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      C-Cell, Hyperplasia                  |                                                    1  2                  |             
      Follicle, Cyst                       |                                           3                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
      Inflammation                         |          2           2     3     3     3              2  2     3  2     3|             
      Metaplasia, Squamous                 | 2                                                                        |             
      Duct, Dilatation                     |                      2                       2                    3      |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2     2              2  3|             
      Congestion                           |                            3                                             |             
      Cyst                                 |                2                          2     2                    2   |             
      Cyst, Multiple                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                          |             
      Hemorrhage                           |                                                          4               |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                       1              2  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Prolapse                             |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                   2                        |             
      Myeloid Cell, Hyperplasia            |          3                                                  2            |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                             +     +               |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                    2                     |             
      Lumbar, Ectasia                      |                                                          2               |             
      Lumbar, Hemorrhage                   |                                                          1               |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                 3     2     3                                          |             
      Infiltration Cellular, Plasma Cell   |    1              3                             2     2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Fibrosis                             |                         3                                                |             
      Hematopoietic Cell Proliferation     |    2  3     2              2        2  2  1  3  2  2        3            |             
      Pigmentation                         | 3        3                       3                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Hyperplasia, Reticulum Cell          | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                        3                                 |             
      Hyperplasia                          |                   3  2  1  1  2  2     2  1  1  2  4  2  3  3  2  2     2|             
      Duct, Dilatation                     |                               2                 2     3  2  2  2        3|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                               1        1                                 |             
      Femur, Osteopetrosis                 |                         2                                                |             
      Sternum, Osteopetrosis               |                         2                                                |             
      Turbinate, Osteopetrosis             |                         2                                                |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                          3     3        1|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          3                                            3                  |             
      Hemorrhage                           | 2                                                                        |             
      Inflammation, Chronic, Focal         |          3                                            3                 1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          3                                            3                  |             
      Inflammation, Suppurative            |          3                                            3                  |             
      Nasolacrimal Duct, Inflammation      |                         2  1     2  1     2              2     2         |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                                          |             
      Respiratory Epithelium, Cytoplasmic  |                                                                          |             
          Alteration                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|             
                                           | 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    600 PPM                                | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|             
                                           | 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation                         |          3                                                               |             
      Epithelium, Hyperplasia              |          3                                            2                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                1                                         2        2  1   |             
      Bilateral, Cataract                  |                      2                                                  2|             
      Bilateral, Retina, Degeneration      |                3                                      2     2     2  2  2|             
      Cornea, Inflammation                 |                         3                                                |             
      Retina, Autolysis                    |       X              X                                                   |             
      Retina, Degeneration                 |                   3                    2        2        2               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1              1  2  1  2     1     1     1     2  1        1     2  2  2|             
      Pigmentation                         | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                              +  +                       +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia                           |                                              2  2                       2|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2  2  2  2  1  2  2  2  2  2  2  2  2  2  1  2  2     2  2  2  1  2  2|             
      Nephropathy                          |          1        1     1  2  1  2     2  1  1     1  2  3  1  1  1  1  3|             
      Renal Tubule, Necrosis               | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Dilatation                           |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |          X  X                                                     X      |      7     |
      Basophilic Focus, Multiple           |                         X     X              X           X  X  X         |      8     |
      Developmental Malformation           | 1                                                                        |      5  1.0|
      Eosinophilic Focus                   | X  X              X     X           X                          X  X      |     11     |
      Eosinophilic Focus, Multiple         |                X           X                                X            |      3     |
      Fatty Change                         |    2                                                                     |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                    2              1      |      5  1.8|
      Hepatodiaphragmatic Nodule           |    X                             X                                X      |      3     |
      Infiltration Cellular, Lymphocyte    |       1                       1  1  1        1                           |      8  1.0|
      Inflammation, Focal, Granulomatous   | 1  2        1  1     1  1  2           1        1     2  1     1         |     19  1.3|
      Mixed Cell Focus, Multiple           |                                                                          |      1     |
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                      2  1              1                                 |      6  1.8|
      Bile Duct, Hyperplasia               |       1                                                        1         |      5  1.2|
      Centrilobular, Necrosis              |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |                         +                    +                           |   4        |
      Fat, Necrosis                        |                         3                    2                           |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |          1                                                               |      2  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |          1     1              1     1                                    |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |                      2  1  1  1     1  1  1  1                           |     14  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |    2        1  2        1  1     1  1           2     2        2         |     16  1.6|
      Atrophy                              |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                 2  2     2               |      4  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic            |                         1                             1                  |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  39        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Angiectasis                          |                                                          2        2      |      2  2.0|
      Pars Distalis, Cyst                  |          1                                         3                     |      9  1.9|
      Pars Distalis, Hyperplasia           |                                                    3     2               |      6  1.8|
      Pars Intermedia, Cyst                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      C-Cell, Hyperplasia                  |       1     2        1                 3                                 |      6  1.7|
      Follicle, Cyst                       |                            1        2                                    |      3  2.0|
      Follicular Cell, Hyperplasia         |    1                                                        1            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                2     2     2           2                          2      |      6  2.2|
      Inflammation                         |    3  3        1  1  3  2  3  2        1  2  2  3  1  2     1     2      |     26  2.2|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Duct, Dilatation                     |                               3     3                             3      |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                1     2  2     3     2                    1               |     10  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |          2  2                                2        3     2     2      |     10  2.1|
      Cyst, Multiple                       |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Decidual Reaction                    |                                                             2            |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Thrombosis                           |                                                    3                     |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2                          2     2           1                 2         |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Prolapse                             |                                                                   3      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      2  2.0|
      Myeloid Cell, Hyperplasia            |                                                    2           2         |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                                     +         |   5        |
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
      Lumbar, Ectasia                      |                                                                4         |      2  3.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  1.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                4         |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Lymphoid                |                                                    2                     |      5  2.6|
      Infiltration Cellular, Plasma Cell   |                                                       2  2        2      |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                   2      |     12  2.2|
      Pigmentation                         |                                                                          |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |  40        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Galactocele                          |                      2                                                   |      2  2.5|
      Hyperplasia                          | 2  2  2  1  2  2     2     2  1  3        1  3  2  3  1  2  2  1         |     35  2.0|
      Duct, Dilatation                     | 2                          2                       2  1                  |     11  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                             1            |      3  1.0|
      Femur, Osteopetrosis                 |                            3                    2                        |      3  2.3|
      Sternum, Osteopetrosis               |                            3                    2                        |      3  2.3|
      Turbinate, Osteopetrosis             |                            3                                             |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hypothalamus, Compression            |                      2        2              2        3                  |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                                                 2  3                     |      4  2.8|
      Hemorrhage                           |                                                       1                  |      2  1.5|
      Inflammation, Chronic, Focal         |             1                 1                 2  3        1            |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Nasolacrimal Duct, Inflammation      |             1  2  3           2     1     1                              |     13  1.7|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                1         |      1  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             |                2           3                                2            |      7  1.9|
      Bilateral, Cataract                  |                                                                          |      2  2.0|
      Bilateral, Retina, Degeneration      | 2  2  2  3  3  3     2  3  3  2  2                       2               |     18  2.3|
      Cornea, Inflammation                 |                                                                          |      1  3.0|
      Retina, Autolysis                    |                                                                          |      2     |
      Retina, Degeneration                 |                                        2     3        1     2     2      |      9  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 93005-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 14:26:54    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     |      A     |
    600 PPM                                | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |    1  1  1  2     1  1  2  3  1  1  1     1  2  1  1        1  2  1      |     32  1.4|
      Pigmentation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          | +     +  +  +  +                          +                              |   9        |
      Infiltration Cellular, Lymphocyte    |       1     1  1                                                         |      3  1.0|
      Metaplasia                           | 2     3  2  2  2                          2                              |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |    1     2  2  2        1        2     2                                 |     30  1.8|
      Nephropathy                          | 2  1  2  1  2  3  1  3  1  2  1  1  1  2  1  1  2  1  1  1  1  1  1      |     40  1.5|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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