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TDMS Study 93023-06 Pathology Tables

NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01
Route: GAVAGE                                                                                                     Time: 15:12:24

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  142-83-6

       Lock Date:  02/28/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            9            6            9                                     
    Natural Death                                      1            1            2            4                                     
    Dosing Accident                                                 1            1            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           38           41           31                                     
    Natural Death                                                   1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (50)                                   
   Intestine Large, Rectum                            (49)         (50)         (50)         (49)                                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (49)         (50)         (50)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
   Mesentery                                          (13)         (16)         (19)         (15)                                   
   Oral Mucosa                                        (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Adenoma                                  1 (2%)                                 1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Papilloma                                       1 (2%)       4 (8%)      16 (32%)                               
      Squamous Cell Papilloma, Multiple                                          1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
   Tongue                                             (1)                       (2)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (50%)                                            
      Squamous Cell Papilloma                                                    1 (50%)      1 (100%)                              
   Tooth                                              (1)                                                                           
      Odontogenic Tumor                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                 1 (2%)                                
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)       5 (10%)      5 (10%)      1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          19 (38%)     26 (52%)     22 (44%)     20 (40%)                               
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                 11 (22%)      6 (12%)      7 (14%)      6 (12%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          5 (10%)      8 (16%)     11 (22%)      7 (14%)                               
      Carcinoma                                        2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Thecoma Malignant                                             1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
      Deciduoma Benign                                                                        1 (2%)                                
      Polyp Stromal                                   14 (28%)     11 (22%)      9 (18%)     13 (26%)                               
      Sarcoma Stromal                                                            1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Vagina                                             (1)          (3)          (1)          (1)                                    
      Sarcoma                                                       1 (33%)                                                         
      Sarcoma Stromal, Metastatic, Uterus                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (29)         (30)         (30)         (38)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (3%)                                
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (3%)                                                          
   Lymph Node, Mandibular                             (6)          (2)          (5)          (1)                                    
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (48)         (47)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        2 (4%)       3 (6%)                    1 (2%)                                
      Fibroadenoma                                    22 (44%)     28 (56%)     22 (44%)     18 (36%)                               
      Schwannoma Benign                                                                       1 (2%)                                
   Skin                                               (49)         (49)         (50)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Keratoacanthoma                                  1 (2%)                                                                       
      Neural Crest Tumor                                                         1 (2%)                                             
      Pinna, Neural Crest Tumor                                                  1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)                    1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            2 (4%)                                                                       
      Glioma Malignant                                                           1 (2%)                                             
      Oligodendroglioma Malignant                                   1 (2%)                                                          
   Spinal Cord                                        (3)          (1)                                                              
      Astrocytoma Malignant, Metastatic, Brain         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Papilloma                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            10 (20%)     11 (22%)      5 (10%)     16 (32%)                               
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          48          44                                       
     Total Primary Neoplasms                          109         112         106         113                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          45          43          44                                       
     Total Benign Neoplasms                            86          89          88          89                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          19          14          21                                       
     Total Malignant Neoplasms                         22          23          16          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1           1                                       
     Total Metastatic Neoplasm                          1           1           1           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       2                                                   
     Total Uncertain Neoplasms                          1                       2                                                   
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           11           13           10                                     
    Dosing Accident                                    1            2            1            5                                     
    Natural Death                                      2            2            3            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           35           33           30                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (49)         (50)         (50)         (47)                                   
   Intestine Small, Ileum                             (49)         (49)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (13)         (8)          (19)         (17)                                   
      Hemangiosarcoma                                                                         1 (6%)                                
   Oral Mucosa                                        (1)          (1)          (1)          (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Adenoma                                 10 (20%)      5 (10%)      9 (18%)      6 (12%)                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Lipoma                                           1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    1 (2%)       2 (4%)                                
      Squamous Cell Papilloma                                       3 (6%)      10 (20%)     18 (36%)                               
      Squamous Cell Papilloma, Multiple                                                      11 (22%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (2)          (1)          (2)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (50%)                                            
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)       1 (2%)       4 (8%)                                
      Pheochromocytoma Complex                                      1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          7 (14%)      6 (12%)      7 (14%)      7 (14%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          4 (8%)       6 (12%)      5 (10%)      1 (2%)                                
      Carcinoma                                                     2 (4%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          12 (24%)     16 (32%)     15 (30%)     19 (38%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      C-Cell, Adenoma                                  4 (8%)       4 (8%)       5 (10%)      6 (12%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                    4 (8%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (4)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       4 (8%)                    1 (2%)                                
      Carcinoma                                        3 (6%)       3 (6%)       5 (10%)      1 (2%)                                
   Prostate                                           (49)         (47)         (50)         (50)                                   
      Ventral, Adenoma                                 2 (4%)       2 (4%)       3 (6%)       3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           35 (70%)     36 (72%)     32 (64%)     40 (80%)                               
      Interstitial Cell, Adenoma                       6 (12%)      9 (18%)     13 (26%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (21)         (27)         (29)         (28)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Zymbal's Gland                                                                      1 (4%)                                
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (4%)                                                          
      Pancreatic, Histiocytic Sarcoma                                            1 (3%)                                             
   Lymph Node, Mandibular                             (8)          (1)          (3)          (2)                                    
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
   Thymus                                             (50)         (49)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (45)         (46)         (44)                                   
      Carcinoma                                        2 (4%)                                                                       
      Fibroadenoma                                     3 (6%)       1 (2%)       1 (2%)       2 (5%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Keratoacanthoma                                  3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      Neural Crest Tumor                               1 (2%)                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Pinna, Neural Crest Tumor                                     1 (2%)                    1 (2%)                                
      Sebaceous Gland, Adenoma                                                   1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     4 (8%)       3 (6%)       6 (12%)      5 (10%)                               
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiopericytoma                       1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
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         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (1)          (6)          (1)          (3)                                    
      Sarcoma                                                       1 (17%)                                                         
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
   Spinal Cord                                        (2)          (4)          (1)          (2)                                    
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             3 (6%)       1 (2%)                                
      Carcinoma, Metastatic, Preputial Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)                       (2)                                    
      Adenoma                                          1 (50%)                                                                      
      Carcinoma                                        1 (50%)      1 (100%)                  2 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            11 (22%)     14 (28%)      9 (18%)     17 (34%)                               
      Mesothelioma Malignant                           4 (8%)       1 (2%)       1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 03/14/01  
Route: GAVAGE                                                                                                     Time: 15:12:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            22.5         45           90                                        
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          48          50          47                                       
     Total Primary Neoplasms                          128         132         147         170                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47          49          46                                       
     Total Benign Neoplasms                            99         100         117         128                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          23          24          30                                       
     Total Malignant Neoplasms                         28          31          30          40                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           1           2                                       
     Total Metastatic Neoplasm                          1           3           3           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                       2                                       
     Total Uncertain Neoplasms                          1           1                       2                                       
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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