Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4154

TDMS Study 93023-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  2,4-HEXADIENAL                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Stomach, Forestomach                   Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
Testes                                 Adenoma                                                                                      
Thyroid Gland: C-Cell                  Carcinoma                                                                                    
All Organs                             Mesothelioma: Benign, Malignant, NOS                                                         
                                       Mesothelioma: Malignant                                                                      
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Mammary Gland                          Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Stomach, Forestomach                   Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   2,4-HEXADIENAL          
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/49 (12%)   7/50 (14%)   7/49 (14%)  |1/50 (2%)    5/49 (10%)   5/50 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/45.23      6/42.62      7/44.04      7/40.62     |1/45.36      5/44.98      5/45.73      1/40.99      | 
|POLY-3 PERCENT (g) |     15.5%        14.1%        15.9%        17.2%       |2.2%         11.1%        10.9%        2.4%         | 
|TERMINAL (d)       |     5/37 (14%)   6/34 (18%)   5/33 (15%)   5/29 (17%)  |1/37 (3%)    4/38 (11%)   4/41 (10%)   0/31 (0%)    | 
|FIRST INCIDENCE    |     587          729 (T)      536          691         |729 (T)      719          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348      P=0.560N     P=0.534      P=0.444     |P=0.507N     P=0.113      P=0.125      P=0.731      | 
|POLY 3             |     P=0.437      P=0.546N     P=0.593      P=0.529     |P=0.493N     P=0.099      P=0.103      P=0.738      | 
|POLY 1.5           |     P=0.460      P=0.538N     P=0.604      P=0.551     |P=0.467N     P=0.098      P=0.103      P=0.745      | 
|POLY 6             |     P=0.412      P=0.554N     P=0.578      P=0.504     |P=0.516N     P=0.100      P=0.103      P=0.731      | 
|LOGISTIC REGRESSION|     P=0.439      P=0.536N     P=0.608      P=0.527     |P=0.458N     P=0.102      P=0.103      P=0.735N     | 
|COCH-ARM / FISHERS |     P=0.503      P=0.516N     P=0.613N     P=0.597     |P=0.417N     P=0.098      P=0.102      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    1/50 (2%)    4/49 (8%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/42.62      1/43.01      4/41.03     |1/45.36      0/44.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.3%         9.8%        |2.2%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/34 (3%)    1/33 (3%)    3/29 (10%)  |1/37 (3%)    0/38 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      496         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.483      P=0.477      P=0.043 *   |P=0.564      P=0.495N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.014 *    P=0.491      P=0.493      P=0.050     |P=0.578      P=0.502N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.015 *    P=0.492      P=0.496      P=0.052     |P=0.584      P=0.503N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.013 *    P=0.491      P=0.488      P=0.047 *   |P=0.572      P=0.501N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.483      P=0.477      P=0.061     |P=0.564      (e)          (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.017 *    P=0.495      P=0.500      P=0.056     |P=0.596      P=0.505N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   8/49 (16%)   9/50 (18%)   11/49 (22%) |2/50 (4%)    5/49 (10%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/45.23      8/42.84      9/44.26      11/41.31    |2/45.36      5/44.98      5/45.73      3/41.23      | 
|POLY-3 PERCENT (g) |     15.5%        18.7%        20.3%        26.6%       |4.4%         11.1%        10.9%        7.3%         | 
|TERMINAL (d)       |     5/37 (14%)   7/34 (21%)   6/33 (18%)   8/29 (28%)  |2/37 (5%)    4/38 (11%)   4/41 (10%)   1/31 (3%)    | 
|FIRST INCIDENCE    |     587          671          536          496         |729 (T)      719          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.073      P=0.438      P=0.318      P=0.107     |P=0.418      P=0.232      P=0.254      P=0.431      | 
|POLY 3             |     P=0.118      P=0.454      P=0.373      P=0.155     |P=0.446      P=0.213      P=0.219      P=0.457      | 
|POLY 1.5           |     P=0.130      P=0.461      P=0.384      P=0.170     |P=0.470      P=0.211      P=0.220      P=0.471      | 
|POLY 6             |     P=0.105      P=0.449      P=0.360      P=0.140     |P=0.426      P=0.215      P=0.220      P=0.445      | 
|LOGISTIC REGRESSION|     P=0.121      P=0.462      P=0.386      P=0.162     |P=0.473      P=0.216      P=0.216      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.156      P=0.483      P=0.393      P=0.204     |P=0.522      P=0.210      P=0.218      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Astrocytoma Malignant                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      1/41.62     |2/46.02      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          655         |511          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184      (e)          (e)          P=0.480     |P=0.123N     P=0.234N     P=0.228N     P=0.272N     | 
|POLY 3             |     P=0.191      (e)          (e)          P=0.486     |P=0.109N     P=0.238N     P=0.240N     P=0.267N     | 
|POLY 1.5           |     P=0.193      (e)          (e)          P=0.490     |P=0.110N     P=0.238N     P=0.238N     P=0.257N     | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.482     |P=0.107N     P=0.237N     P=0.242N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.205      (e)          (e)          P=0.512     |P=0.092N     P=0.242N     P=0.264N     P=0.192N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      1/41.62     |2/46.02      1/46.83      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |4.4%         2.1%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          655         |511          347          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184      (e)          (e)          P=0.480     |P=0.169N     P=0.494N     P=0.476N     P=0.272N     | 
|POLY 3             |     P=0.191      (e)          (e)          P=0.486     |P=0.172N     P=0.494N     P=0.504N     P=0.267N     | 
|POLY 1.5           |     P=0.193      (e)          (e)          P=0.490     |P=0.166N     P=0.496N     P=0.501N     P=0.257N     | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.482     |P=0.178N     P=0.493N     P=0.507N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.205      (e)          (e)          P=0.512     |P=0.091N     P=0.515N     P=0.521N     P=0.192N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    4/50 (8%)    0/50 (0%)    1/50 (2%)   |5/50 (10%)   8/50 (16%)   11/50 (22%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/43.75      4/43.62      0/43.01      1/41.35     |5/45.36      8/46.36      11/45.91     7/40.54      | 
|POLY-3 PERCENT (g) |     2.3%         9.2%         0.0%         2.4%        |11.0%        17.3%        24.0%        17.3%        | 
|TERMINAL (d)       |     1/37 (3%)    4/35 (11%)   0/33 (0%)    1/30 (3%)   |5/37 (14%)   7/39 (18%)   10/41 (24%)  6/31 (19%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      610          602          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.162      P=0.523N     P=0.715     |P=0.215      P=0.310      P=0.122      P=0.259      | 
|POLY 3             |     P=0.355N     P=0.177      P=0.503N     P=0.748     |P=0.242      P=0.290      P=0.087      P=0.302      | 
|POLY 1.5           |     P=0.347N     P=0.179      P=0.500N     P=0.753     |P=0.279      P=0.284      P=0.087      P=0.328      | 
|POLY 6             |     P=0.365N     P=0.176      P=0.509N     P=0.742     |P=0.212      P=0.297      P=0.087      P=0.280      | 
|LOGISTIC REGRESSION|     P=0.407N     P=0.162      (e)          P=0.715     |P=0.234      P=0.285      P=0.084      P=0.248      | 
|COCH-ARM / FISHERS |     P=0.332N     P=0.187      P=0.495N     P=0.747N    |P=0.358      P=0.277      P=0.086      P=0.380      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/50 (6%)    5/50 (10%)   1/50 (2%)   |2/50 (4%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/45.06      3/43.94      5/43.57      1/41.88     |2/45.49      1/45.94      3/45.47      3/40.54      | 
|POLY-3 PERCENT (g) |     6.7%         6.8%         11.5%        2.4%        |4.4%         2.2%         6.6%         7.4%         | 
|TERMINAL (d)       |     1/37 (3%)    1/35 (3%)    3/33 (9%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    3/41 (7%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     259          671          620          566         |704          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340N     P=0.647      P=0.316      P=0.339N    |P=0.222      P=0.491N     P=0.530      P=0.405      | 
|POLY 3             |     P=0.313N     P=0.651      P=0.338      P=0.332N    |P=0.251      P=0.497N     P=0.500      P=0.448      | 
|POLY 1.5           |     P=0.298N     P=0.654      P=0.349      P=0.322N    |P=0.268      P=0.498N     P=0.502      P=0.466      | 
|POLY 6             |     P=0.330N     P=0.650      P=0.324      P=0.342N    |P=0.236      P=0.495N     P=0.497      P=0.431      | 
|LOGISTIC REGRESSION|     P=0.232N     P=0.613N     P=0.378      P=0.183N    |P=0.235      P=0.495N     P=0.500      P=0.439      | 
|COCH-ARM / FISHERS |     P=0.266N     P=0.651N     P=0.369      P=0.301N    |P=0.302      P=0.500N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    7/50 (14%)   5/50 (10%)   2/50 (4%)   |7/50 (14%)   9/50 (18%)   14/50 (28%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     4/45.06      7/43.94      5/43.57      2/41.88     |7/45.49      9/46.36      14/45.91     10/40.69     | 
|POLY-3 PERCENT (g) |     8.9%         15.9%        11.5%        4.8%        |15.4%        19.4%        30.5%        24.6%        | 
|TERMINAL (d)       |     2/37 (5%)    5/35 (14%)   3/33 (9%)    1/30 (3%)   |5/37 (14%)   8/39 (21%)   13/41 (32%)  8/31 (26%)   | 
|FIRST INCIDENCE    |     259          671          620          566         |704          610          602          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.246      P=0.446      P=0.399N    |P=0.110      P=0.434      P=0.110      P=0.172      | 
|POLY 3             |     P=0.218N     P=0.246      P=0.479      P=0.371N    |P=0.135      P=0.408      P=0.069      P=0.212      | 
|POLY 1.5           |     P=0.204N     P=0.251      P=0.492      P=0.359N    |P=0.166      P=0.402      P=0.070      P=0.240      | 
|POLY 6             |     P=0.235N     P=0.244      P=0.464      P=0.385N    |P=0.112      P=0.415      P=0.068      P=0.190      | 
|LOGISTIC REGRESSION|     P=0.165N     P=0.285      P=0.527      P=0.247N    |P=0.123      P=0.405      P=0.067      P=0.173      | 
|COCH-ARM / FISHERS |     P=0.172N     P=0.274      P=0.513      P=0.329N    |P=0.237      P=0.393      P=0.070      P=0.298      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   5/50 (10%)   1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.19      6/44.23      5/43.01      1/41.35     |1/45.37      1/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         13.6%        11.6%        2.4%        |2.2%         2.2%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    3/35 (9%)    5/33 (15%)   1/30 (3%)   |0/37 (0%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          659          729 (T)      729 (T)     |727          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169N     P=0.355      P=0.433      P=0.238N    |P=0.347N     P=0.752N     P=0.740N     P=0.541N     | 
|POLY 3             |     P=0.141N     P=0.356      P=0.469      P=0.207N    |P=0.337N     P=0.758N     P=0.760N     P=0.523N     | 
|POLY 1.5           |     P=0.129N     P=0.357      P=0.484      P=0.197N    |P=0.329N     P=0.759N     P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.156N     P=0.359      P=0.449      P=0.217N    |P=0.345N     P=0.757N     P=0.760      P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.128N     P=0.364      P=0.476      P=0.189N    |P=0.354N     P=0.756N     P=0.759N     P=0.541N     | 
|COCH-ARM / FISHERS |     P=0.109N     P=0.370      P=0.500      P=0.181N    |P=0.311N     P=0.753N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      2/43.72      0/43.01      1/41.35     |0/45.36      1/46.19      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         2.4%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          704          ---          729 (T)     |---          664          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.234      (e)          P=0.458     |P=0.597N     P=0.505      (e)          (e)          | 
|POLY 3             |     P=0.511      P=0.232      (e)          P=0.485     |P=0.568N     P=0.504      (e)          (e)          | 
|POLY 1.5           |     P=0.520      P=0.233      (e)          P=0.490     |P=0.568N     P=0.502      (e)          (e)          | 
|POLY 6             |     P=0.501      P=0.233      (e)          P=0.479     |P=0.567N     P=0.506      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.508      P=0.232      (e)          P=0.458     |P=0.551N     P=0.497      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   5/50 (10%)   2/50 (4%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.19      7/44.23      5/43.01      2/41.35     |1/45.37      2/46.19      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         15.8%        11.6%        4.8%        |2.2%         4.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    4/35 (11%)   5/33 (15%)   2/30 (7%)   |0/37 (0%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          659          729 (T)      729 (T)     |727          664          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268N     P=0.250      P=0.433      P=0.424N    |P=0.285N     P=0.512      P=0.740N     P=0.541N     | 
|POLY 3             |     P=0.226N     P=0.248      P=0.469      P=0.379N    |P=0.276N     P=0.506      P=0.760N     P=0.523N     | 
|POLY 1.5           |     P=0.209N     P=0.250      P=0.484      P=0.365N    |P=0.266N     P=0.504      P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.247N     P=0.250      P=0.449      P=0.395N    |P=0.285N     P=0.510      P=0.760      P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.212N     P=0.255      P=0.476      P=0.360N    |P=0.269N     P=0.502      P=0.759N     P=0.541N     | 
|COCH-ARM / FISHERS |     P=0.179N     P=0.262      P=0.500      P=0.339N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    4/50 (8%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      0/43.62      4/43.89      1/41.35     |3/45.46      1/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         9.1%         2.4%        |6.6%         2.2%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    3/33 (9%)    1/30 (3%)   |2/37 (5%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          364          729 (T)     |704          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381      P=0.511N     P=0.156      P=0.715     |P=0.088N     P=0.293N     P=0.282N     P=0.162N     | 
|POLY 3             |     P=0.400      P=0.505N     P=0.173      P=0.744     |P=0.082N     P=0.302N     P=0.305N     P=0.141N     | 
|POLY 1.5           |     P=0.414      P=0.504N     P=0.177      P=0.749     |P=0.079N     P=0.303N     P=0.304N     P=0.133N     | 
|POLY 6             |     P=0.384      P=0.505N     P=0.167      P=0.738     |P=0.085N     P=0.300N     P=0.307N     P=0.149N     | 
|LOGISTIC REGRESSION|     P=0.456      (e)          P=0.184      P=0.715     |P=0.088N     P=0.298N     P=0.304N     P=0.149N     | 
|COCH-ARM / FISHERS |     P=0.444      P=0.500N     P=0.181      P=0.753N    |P=0.073N     P=0.309N     P=0.309N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      3/43.01      1/41.35     |0/45.36      0/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.0%         2.4%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    3/33 (9%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      (e)          P=0.101      P=0.458     |P=0.679      (e)          P=0.520      (e)          | 
|POLY 3             |     P=0.214      (e)          P=0.112      P=0.485     |P=0.639      (e)          P=0.500      (e)          | 
|POLY 1.5           |     P=0.224      (e)          P=0.115      P=0.490     |P=0.659      (e)          P=0.501      (e)          | 
|POLY 6             |     P=0.203      (e)          P=0.107      P=0.479     |P=0.620      (e)          P=0.500      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.101      P=0.458     |(e)          (e)          P=0.520      (e)          | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   2/50 (4%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      0/43.62      6/43.89      2/41.35     |3/45.46      1/45.94      2/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         13.7%        4.8%        |6.6%         2.2%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    5/33 (15%)   2/30 (7%)   |2/37 (5%)    1/39 (3%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          364          729 (T)     |704          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165      P=0.511N     P=0.045 *    P=0.427     |P=0.128N     P=0.293N     P=0.465N     P=0.162N     | 
|POLY 3             |     P=0.184      P=0.505N     P=0.053      P=0.473     |P=0.123N     P=0.302N     P=0.500N     P=0.141N     | 
|POLY 1.5           |     P=0.196      P=0.504N     P=0.055      P=0.482     |P=0.116N     P=0.303N     P=0.498N     P=0.133N     | 
|POLY 6             |     P=0.170      P=0.505N     P=0.049 *    P=0.464     |P=0.129N     P=0.300N     P=0.502N     P=0.149N     | 
|LOGISTIC REGRESSION|     P=0.220      (e)          P=0.060      P=0.427     |P=0.128N     P=0.298N     P=0.500N     P=0.149N     | 
|COCH-ARM / FISHERS |     P=0.227      P=0.500N     P=0.056      P=0.500     |P=0.104N     P=0.309N     P=0.500N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      0/41.35     |2/45.43      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |712          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.126N     P=0.229N     P=0.226N     P=0.285N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.235N     P=0.237N     P=0.264N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.236N     P=0.236N     P=0.255N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.234N     P=0.238N     P=0.274N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.124N     P=0.234N     P=0.237N     P=0.272N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.73      0/43.62      0/43.01      0/41.35     |2/45.53      3/45.98      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |4.4%         6.5%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    2/39 (5%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     704          ---          ---          ---         |704          719          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.246N     P=0.265N     P=0.279N    |P=0.297N     P=0.520      P=0.240N     P=0.577N     | 
|POLY 3             |     P=0.110N     P=0.243N     P=0.246N     P=0.255N    |P=0.260N     P=0.505      P=0.237N     P=0.542N     | 
|POLY 1.5           |     P=0.111N     P=0.242N     P=0.242N     P=0.249N    |P=0.254N     P=0.503      P=0.237N     P=0.527N     | 
|POLY 6             |     P=0.110N     P=0.243N     P=0.252N     P=0.262N    |P=0.266N     P=0.506      P=0.239N     P=0.556N     | 
|LOGISTIC REGRESSION|     P=0.123N     P=0.242N     P=0.250N     P=0.259N    |P=0.282N     P=0.507      P=0.237N     P=0.547N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.242N     P=0.500      P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.73      0/43.62      0/43.01      0/41.35     |3/45.53      3/45.98      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |6.6%         6.5%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    2/39 (5%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     704          ---          ---          ---         |704          719          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.246N     P=0.265N     P=0.279N    |P=0.173N     P=0.638N     P=0.118N     P=0.385N     | 
|POLY 3             |     P=0.110N     P=0.243N     P=0.246N     P=0.255N    |P=0.147N     P=0.658N     P=0.119N     P=0.349N     | 
|POLY 1.5           |     P=0.111N     P=0.242N     P=0.242N     P=0.249N    |P=0.142N     P=0.659N     P=0.118N     P=0.334N     | 
|POLY 6             |     P=0.110N     P=0.243N     P=0.252N     P=0.262N    |P=0.151N     P=0.656N     P=0.120N     P=0.365N     | 
|LOGISTIC REGRESSION|     P=0.123N     P=0.242N     P=0.250N     P=0.259N    |P=0.164N     P=0.656N     P=0.120N     P=0.359N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.134N     P=0.661N     P=0.121N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |22/50 (44%)  28/50 (56%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     3/44.63      1/43.62      1/43.40      2/41.75     |22/47.24     28/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         4.8%        |46.6%        59.3%        48.1%        42.5%        | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |16/37 (43%)  23/39 (59%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541N     P=0.325N     P=0.340N     P=0.580N    |P=0.349N     P=0.243      P=0.431N     P=0.529N     | 
|POLY 3             |     P=0.486N     P=0.313N     P=0.315N     P=0.530N    |P=0.249N     P=0.148      P=0.524      P=0.432N     | 
|POLY 1.5           |     P=0.482N     P=0.312N     P=0.310N     P=0.522N    |P=0.193N     P=0.151      P=0.554      P=0.373N     | 
|POLY 6             |     P=0.491N     P=0.313N     P=0.322N     P=0.539N    |P=0.306N     P=0.145      P=0.485      P=0.486N     | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.325N     P=0.312N     P=0.534N    |P=0.229N     P=0.164      P=0.577N     P=0.374N     | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.309N     P=0.309N     P=0.500N    |P=0.115N     P=0.159      P=0.580N     P=0.270N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |23/50 (46%)  28/50 (56%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     3/44.63      1/43.62      1/43.40      2/41.75     |23/47.24     28/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         4.8%        |48.7%        59.3%        48.1%        42.5%        | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |17/37 (46%)  23/39 (59%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541N     P=0.325N     P=0.340N     P=0.580N    |P=0.293N     P=0.305      P=0.353N     P=0.461N     | 
|POLY 3             |     P=0.486N     P=0.313N     P=0.315N     P=0.530N    |P=0.197N     P=0.201      P=0.560N     P=0.355N     | 
|POLY 1.5           |     P=0.482N     P=0.312N     P=0.310N     P=0.522N    |P=0.149N     P=0.204      P=0.529N     P=0.299N     | 
|POLY 6             |     P=0.491N     P=0.313N     P=0.322N     P=0.539N    |P=0.247N     P=0.198      P=0.566      P=0.407N     | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.325N     P=0.312N     P=0.534N    |P=0.182N     P=0.220      P=0.496N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.309N     P=0.309N     P=0.500N    |P=0.086N     P=0.212      P=0.500N     P=0.208N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    1/50 (2%)    2/50 (4%)   |24/50 (48%)  30/50 (60%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     5/44.73      1/43.62      1/43.40      2/41.75     |24/47.34     30/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     11.2%        2.3%         2.3%         4.8%        |50.7%        63.6%        48.1%        42.5%        | 
|TERMINAL (d)       |     4/37 (11%)   1/35 (3%)    0/33 (0%)    0/30 (0%)   |17/37 (46%)  25/39 (64%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     704          729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.116N     P=0.131N     P=0.298N    |P=0.208N     P=0.251      P=0.289N     P=0.399N     | 
|POLY 3             |     P=0.199N     P=0.107N     P=0.108N     P=0.244N    |P=0.123N     P=0.143      P=0.483N     P=0.287N     | 
|POLY 1.5           |     P=0.196N     P=0.106N     P=0.105N     P=0.236N    |P=0.088N     P=0.147      P=0.449N     P=0.235N     | 
|POLY 6             |     P=0.203N     P=0.107N     P=0.112N     P=0.253N    |P=0.164N     P=0.137      P=0.528N     P=0.338N     | 
|LOGISTIC REGRESSION|     P=0.209N     P=0.108N     P=0.110N     P=0.249N    |P=0.113N     P=0.164      P=0.415N     P=0.239N     | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.102N     P=0.102N     P=0.218N    |P=0.047N*    P=0.158      P=0.421N     P=0.156N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.97      1/43.62      2/43.69      1/41.35     |1/45.39      0/45.94      2/46.19      1/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         4.6%         2.4%        |2.2%         0.0%         4.3%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     634          729 (T)      606          729 (T)     |722          ---          476          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.544      P=0.757      P=0.483      P=0.729     |P=0.448      P=0.495N     P=0.522      P=0.715      | 
|POLY 3             |     P=0.554      P=0.754      P=0.490      P=0.742     |P=0.445      P=0.498N     P=0.506      P=0.734      | 
|POLY 1.5           |     P=0.566      P=0.755      P=0.495      P=0.748     |P=0.464      P=0.499N     P=0.505      P=0.743      | 
|POLY 6             |     P=0.539      P=0.753      P=0.483      P=0.734     |P=0.427      P=0.497N     P=0.507      P=0.725      | 
|LOGISTIC REGRESSION|     P=0.598      P=0.761N     P=0.504      P=0.763     |P=0.534      P=0.496N     P=0.469      P=0.720      | 
|COCH-ARM / FISHERS |     P=0.591      P=0.753N     P=0.500      P=0.753N    |P=0.500      P=0.500N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  5/50 (10%)   9/50 (18%)   6/50 (12%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/44.85     5/43.62      9/43.18      6/41.35     |1/45.36      0/45.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     22.3%        11.5%        20.8%        14.5%       |2.2%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     8/37 (22%)   5/35 (14%)   8/33 (24%)   6/30 (20%)  |1/37 (3%)    0/39 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     699          729 (T)      686          729 (T)     |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.435N     P=0.156N     P=0.590      P=0.352N    |P=0.562      P=0.489N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.326N     P=0.140N     P=0.537N     P=0.257N    |P=0.576      P=0.497N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.307N     P=0.139N     P=0.519N     P=0.240N    |P=0.583      P=0.499N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.350N     P=0.141N     P=0.563N     P=0.279N    |P=0.571      P=0.496N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.390N     P=0.139N     P=0.585N     P=0.303N    |P=0.562      (e)          (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.273N     P=0.131N     P=0.500N     P=0.207N    |P=0.595      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  16/50 (32%)  15/50 (30%)  19/50 (38%) |19/50 (38%)  26/50 (52%)  22/50 (44%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     12/46.24     16/45.27     15/44.33     19/43.17    |19/46.82     26/47.13     22/46.58     20/41.81     | 
|POLY-3 PERCENT (g) |     26.0%        35.3%        33.8%        44.0%       |40.6%        55.2%        47.2%        47.8%        | 
|TERMINAL (d)       |     8/37 (22%)   10/35 (29%)  10/33 (30%)  12/30 (40%) |12/37 (32%)  21/39 (54%)  19/41 (46%)  15/31 (48%)  | 
|FIRST INCIDENCE    |     542          537          560          574         |560          610          602          560          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.039 *    P=0.234      P=0.239      P=0.043 *   |P=0.321      P=0.186      P=0.466      P=0.260      | 
|POLY 3             |     P=0.055      P=0.227      P=0.277      P=0.055     |P=0.399      P=0.111      P=0.330      P=0.318      | 
|POLY 1.5           |     P=0.067      P=0.230      P=0.299      P=0.065     |P=0.477      P=0.111      P=0.341      P=0.379      | 
|POLY 6             |     P=0.046 *    P=0.230      P=0.251      P=0.048 *   |P=0.331      P=0.111      P=0.315      P=0.266      | 
|LOGISTIC REGRESSION|     P=0.071      P=0.244      P=0.313      P=0.072     |P=0.423      P=0.119      P=0.346      P=0.334      | 
|COCH-ARM / FISHERS |     P=0.098      P=0.252      P=0.326      P=0.097     |P=0.452N     P=0.114      P=0.342      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/47 (4%)    3/50 (6%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     2/43.63      2/40.96      3/43.01      3/41.35     |                                                    | 
|POLY-3 PERCENT (g) |     4.6%         4.9%         7.0%         7.3%        |                                                    | 
|TERMINAL (d)       |     2/36 (6%)    2/33 (6%)    3/33 (9%)    3/30 (10%)  |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.664      P=0.460      P=0.417     |                                                    | 
|POLY 3             |     P=0.352      P=0.671      P=0.494      P=0.475     |                                                    | 
|POLY 1.5           |     P=0.365      P=0.672      P=0.501      P=0.486     |                                                    | 
|POLY 6             |     P=0.337      P=0.673      P=0.483      P=0.464     |                                                    | 
|LOGISTIC REGRESSION|     P=0.294      P=0.664      P=0.460      P=0.417     |                                                    | 
|COCH-ARM / FISHERS |     P=0.389      P=0.676      P=0.510      P=0.510     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.63      2/43.62      3/43.01      2/41.35     |1/45.36      0/45.94      1/45.73      0/40.39      | 
|POLY-3 PERCENT (g) |     11.2%        4.6%         7.0%         4.8%        |2.2%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     5/37 (14%)   2/35 (6%)    3/33 (9%)    2/30 (7%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          659          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.238N     P=0.420N     P=0.307N    |P=0.441N     P=0.489N     P=0.752N     P=0.535N     | 
|POLY 3             |     P=0.233N     P=0.225N     P=0.376N     P=0.248N    |P=0.423N     P=0.497N     P=0.759N     P=0.523N     | 
|POLY 1.5           |     P=0.225N     P=0.224N     P=0.367N     P=0.238N    |P=0.417N     P=0.499N     P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.243N     P=0.224N     P=0.390N     P=0.259N    |P=0.429N     P=0.496N     P=0.759N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.238N     P=0.420N     P=0.307N    |P=0.408N     (e)          P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.210N     P=0.218N     P=0.357N     P=0.218N    |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    6/50 (12%)   5/50 (10%)  |2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/45.11      3/43.93      6/43.69      5/41.95     |2/45.61      0/45.94      1/45.47      2/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         6.8%         13.7%        11.9%       |4.4%         0.0%         2.2%         5.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/35 (6%)    5/33 (15%)   3/30 (10%)  |1/37 (3%)    0/39 (0%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     587          643          503          636         |664          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.521N     P=0.313      P=0.400     |P=0.408      P=0.231N     P=0.479N     P=0.629      | 
|POLY 3             |     P=0.293      P=0.514N     P=0.349      P=0.454     |P=0.435      P=0.236N     P=0.501N     P=0.649      | 
|POLY 1.5           |     P=0.308      P=0.512N     P=0.360      P=0.468     |P=0.447      P=0.236N     P=0.499N     P=0.665      | 
|POLY 6             |     P=0.278      P=0.515N     P=0.333      P=0.441     |P=0.425      P=0.235N     P=0.504N     P=0.634      | 
|LOGISTIC REGRESSION|     P=0.317      P=0.505N     P=0.367      P=0.476     |P=0.425      P=0.238N     P=0.499N     P=0.651      | 
|COCH-ARM / FISHERS |     P=0.338      P=0.500N     P=0.370      P=0.500     |P=0.469      P=0.247N     P=0.500N     P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/50 (8%)    7/50 (14%)   5/50 (10%)  |2/50 (4%)    1/50 (2%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/45.11      4/44.03      7/43.69      5/41.95     |2/45.61      1/45.97      2/45.73      3/40.99      | 
|POLY-3 PERCENT (g) |     15.5%        9.1%         16.0%        11.9%       |4.4%         2.2%         4.4%         7.3%         | 
|TERMINAL (d)       |     6/37 (16%)   2/35 (6%)    6/33 (18%)   3/30 (10%)  |1/37 (3%)    0/39 (0%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     587          643          503          636         |664          722          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.558N     P=0.289N     P=0.534      P=0.506N    |P=0.245      P=0.488N     P=0.678N     P=0.429      | 
|POLY 3             |     P=0.474N     P=0.274N     P=0.589      P=0.431N    |P=0.274      P=0.497N     P=0.693N     P=0.452      | 
|POLY 1.5           |     P=0.458N     P=0.273N     P=0.602      P=0.415N    |P=0.287      P=0.498N     P=0.692N     P=0.468      | 
|POLY 6             |     P=0.493N     P=0.273N     P=0.570      P=0.446N    |P=0.262      P=0.496N     P=0.694      P=0.436      | 
|LOGISTIC REGRESSION|     P=0.463N     P=0.271N     P=0.597      P=0.422N    |P=0.315      P=0.499N     P=0.694      P=0.501      | 
|COCH-ARM / FISHERS |     P=0.426N     P=0.262N     P=0.613N     P=0.380N    |P=0.313      P=0.500N     P=0.691N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.63      1/43.72      1/43.01      0/41.35     |0/45.36      1/45.97      0/45.47      1/40.99      | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         0.0%        |0.0%         2.2%         0.0%         2.4%         | 
|TERMINAL (d)       |     3/37 (8%)    0/35 (0%)    1/33 (3%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      704          729 (T)      ---         |---          722          ---          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.322N     P=0.346N     P=0.160N    |P=0.370      P=0.505      (e)          P=0.482      | 
|POLY 3             |     P=0.078N     P=0.313N     P=0.318N     P=0.133N    |P=0.380      P=0.503      (e)          P=0.480      | 
|POLY 1.5           |     P=0.076N     P=0.312N     P=0.312N     P=0.128N    |P=0.388      P=0.502      (e)          P=0.487      | 
|POLY 6             |     P=0.080N     P=0.311N     P=0.327N     P=0.138N    |P=0.373      P=0.504      (e)          P=0.474      | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.313N     P=0.346N     (e)         |P=0.460      P=0.504      (e)          P=0.586      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.309N     P=0.309N     P=0.121N    |P=0.405      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.63      1/43.72      1/43.01      0/41.35     |0/45.36      1/45.97      1/45.73      1/40.99      | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         0.0%        |0.0%         2.2%         2.2%         2.4%         | 
|TERMINAL (d)       |     3/37 (8%)    0/35 (0%)    1/33 (3%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      704          729 (T)      ---         |---          722          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.322N     P=0.346N     P=0.160N    |P=0.339      P=0.505      P=0.495      P=0.482      | 
|POLY 3             |     P=0.078N     P=0.313N     P=0.318N     P=0.133N    |P=0.345      P=0.503      P=0.502      P=0.480      | 
|POLY 1.5           |     P=0.076N     P=0.312N     P=0.312N     P=0.128N    |P=0.358      P=0.502      P=0.502      P=0.487      | 
|POLY 6             |     P=0.080N     P=0.311N     P=0.327N     P=0.138N    |P=0.333      P=0.504      P=0.502      P=0.474      | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.313N     P=0.346N     (e)         |P=0.440      P=0.504      P=0.489      P=0.586      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.309N     P=0.309N     P=0.121N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.63      2/43.62      1/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     6.7%         4.6%         2.3%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/35 (6%)    1/33 (3%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.526N     P=0.346N     P=0.382N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.214N     P=0.510N     P=0.318N     P=0.333N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.209N     P=0.509N     P=0.312N     P=0.324N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.221N     P=0.511N     P=0.327N     P=0.343N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.526N     P=0.346N     P=0.382N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.309N     P=0.309N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Neural Crest Tumor                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      1/44.28      0/43.01      2/41.35     |0/45.36      0/45.94      2/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         4.8%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    2/30 (7%)   |0/37 (0%)    0/39 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      509          ---          729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.752      P=0.523N     P=0.427     |P=0.562      (e)          P=0.261      (e)          | 
|POLY 3             |     P=0.349      P=0.759      P=0.507N     P=0.473     |P=0.524      (e)          P=0.238      (e)          | 
|POLY 1.5           |     P=0.356      P=0.758      P=0.504N     P=0.482     |P=0.549      (e)          P=0.238      (e)          | 
|POLY 6             |     P=0.342      P=0.760      P=0.512N     P=0.464     |P=0.500      (e)          P=0.237      (e)          | 
|LOGISTIC REGRESSION|     P=0.371      P=0.743N     (e)          P=0.427     |(e)          (e)          P=0.261      (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/43.96      0/43.01      0/41.35     |0/45.36      0/45.94      2/46.05      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          634          ---          ---         |---          ---          544          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581N     P=0.505      (e)          (e)         |P=0.567      (e)          P=0.251      (e)          | 
|POLY 3             |     P=0.574N     P=0.497      (e)          (e)         |P=0.522      (e)          P=0.241      (e)          | 
|POLY 1.5           |     P=0.572N     P=0.497      (e)          (e)         |P=0.548      (e)          P=0.240      (e)          | 
|POLY 6             |     P=0.577N     P=0.498      (e)          (e)         |P=0.497      (e)          P=0.241      (e)          | 
|LOGISTIC REGRESSION|     P=0.551N     P=0.515      (e)          (e)         |P=0.639      (e)          P=0.210      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.63      2/43.62      2/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     9.0%         4.6%         4.7%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/37 (11%)   2/35 (6%)    2/33 (6%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.151N     P=0.348N     P=0.354N     P=0.202N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.146N     P=0.346N     P=0.346N     P=0.195N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.158N     P=0.347N     P=0.366N     P=0.211N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.339N     P=0.339N     P=0.181N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.63      2/43.62      2/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     9.0%         4.6%         4.7%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/37 (11%)   2/35 (6%)    2/33 (6%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.151N     P=0.348N     P=0.354N     P=0.202N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.146N     P=0.346N     P=0.346N     P=0.195N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.158N     P=0.347N     P=0.366N     P=0.211N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.339N     P=0.339N     P=0.181N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      1/43.01      2/41.35     |0/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    1/33 (3%)    2/30 (7%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051      (e)          P=0.477      P=0.193     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.063      (e)          P=0.493      P=0.220     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.065      (e)          P=0.496      P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.060      (e)          P=0.488      P=0.215     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.477      P=0.193     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    11/50 (22%)  29/50 (58%) |0/50 (0%)    1/50 (2%)    5/50 (10%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     0/44.63      3/43.62      11/43.16     29/43.31    |0/45.36      1/45.94      5/45.47      17/40.57     | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         25.5%        67.0%       |0.0%         2.2%         11.0%        41.9%        | 
|TERMINAL (d)       |     0/37 (0%)    3/35 (9%)    10/33 (30%)  23/30 (77%) |0/37 (0%)    1/39 (3%)    5/41 (12%)   15/31 (48%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      691          574         |---          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.503      P=0.031 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.115      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.501      P=0.031 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.504      P=0.030 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    10/50 (20%)  29/50 (58%) |0/50 (0%)    1/50 (2%)    5/50 (10%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     0/44.63      3/43.62      10/43.16     29/43.31    |0/45.36      1/45.94      5/45.47      17/40.57     | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         23.2%        67.0%       |0.0%         2.2%         11.0%        41.9%        | 
|TERMINAL (d)       |     0/37 (0%)    3/35 (9%)    9/33 (27%)   23/30 (77%) |0/37 (0%)    1/39 (3%)    5/41 (12%)   15/31 (48%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      691          574         |---          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.503      P=0.031 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.115      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.501      P=0.031 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.504      P=0.030 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  45/50 (90%)  45/50 (90%)  46/50 (92%) |                                                    | 
|POLY-3 RATE (b)    |     41/47.06     45/46.90     45/47.72     46/46.37    |                                                    | 
|POLY-3 PERCENT (g) |     87.1%        96.0%        94.3%        99.2%       |                                                    | 
|TERMINAL (d)       |     33/37 (89%)  35/35 (100%) 32/33 (97%)  30/30 (100%)|                                                    | 
|FIRST INCIDENCE    |     479          509          503          496         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.144      P=0.072      P=0.013 *   |                                                    | 
|POLY 3             |     P=0.012 *    P=0.098      P=0.175      P=0.015 *   |                                                    | 
|POLY 1.5           |     P=0.019 *    P=0.106      P=0.179      P=0.022 *   |                                                    | 
|POLY 6             |     P=0.014 *    P=0.113      P=0.187      P=0.022 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.076      P=0.103      P=0.007 **  |                                                    | 
|COCH-ARM / FISHERS |     P=0.108      P=0.194      P=0.194      P=0.117     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   6/50 (12%)   6/50 (12%)  |12/50 (24%)  6/50 (12%)   7/50 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/44.63      5/43.96      6/43.48      6/41.73     |12/45.36     6/46.19      7/45.47      6/40.54      | 
|POLY-3 PERCENT (g) |     9.0%         11.4%        13.8%        14.4%       |26.5%        13.0%        15.4%        14.8%        | 
|TERMINAL (d)       |     4/37 (11%)   4/35 (11%)   4/33 (12%)   5/30 (17%)  |12/37 (32%)  4/39 (10%)   7/41 (17%)   5/31 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      634          663          620         |729 (T)      671          729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      P=0.471      P=0.309      P=0.253     |P=0.191N     P=0.078N     P=0.096N     P=0.180N     | 
|POLY 3             |     P=0.261      P=0.490      P=0.353      P=0.327     |P=0.155N     P=0.086N     P=0.149N     P=0.144N     | 
|POLY 1.5           |     P=0.275      P=0.490      P=0.361      P=0.340     |P=0.139N     P=0.090N     P=0.149N     P=0.126N     | 
|POLY 6             |     P=0.245      P=0.494      P=0.343      P=0.315     |P=0.171N     P=0.081N     P=0.149N     P=0.162N     | 
|LOGISTIC REGRESSION|     P=0.249      P=0.486      P=0.331      P=0.302     |P=0.199N     P=0.085N     P=0.096N     P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.306      P=0.500      P=0.370      P=0.370     |P=0.111N     P=0.096N     P=0.154N     P=0.096N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.63      1/43.62      0/43.01      4/41.64     |1/45.36      1/45.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         9.6%        |2.2%         2.2%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    1/35 (3%)    0/33 (0%)    3/30 (10%)  |1/37 (3%)    1/39 (3%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          651         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    P=0.749      P=0.523N     P=0.131     |P=0.655      P=0.750N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.055      P=0.756      P=0.507N     P=0.158     |P=0.620N     P=0.758N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.057      P=0.756      P=0.504N     P=0.164     |P=0.619N     P=0.759N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.053      P=0.756      P=0.512N     P=0.152     |P=0.621N     P=0.757N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.049 *    P=0.749      (e)          P=0.152     |P=0.655      P=0.750N     (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.062      P=0.753N     P=0.500N     P=0.181     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   6/50 (12%)   9/50 (18%)  |13/50 (26%)  7/50 (14%)   7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     5/44.63      6/43.96      6/43.48      9/42.02     |13/45.36     7/46.19      7/45.47      7/40.54      | 
|POLY-3 PERCENT (g) |     11.2%        13.7%        13.8%        21.4%       |28.7%        15.2%        15.4%        17.3%        | 
|TERMINAL (d)       |     5/37 (14%)   5/35 (14%)   4/33 (12%)   7/30 (23%)  |13/37 (35%)  5/39 (13%)   7/41 (17%)   6/31 (19%)   | 
|FIRST INCIDENCE    |     729 (T)      634          663          620         |729 (T)      671          729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072      P=0.466      P=0.429      P=0.105     |P=0.200N     P=0.084N     P=0.060N     P=0.200N     | 
|POLY 3             |     P=0.115      P=0.489      P=0.482      P=0.158     |P=0.159N     P=0.093N     P=0.100N     P=0.160N     | 
|POLY 1.5           |     P=0.124      P=0.489      P=0.491      P=0.168     |P=0.142N     P=0.098N     P=0.100N     P=0.139N     | 
|POLY 6             |     P=0.107      P=0.493      P=0.471      P=0.150     |P=0.175N     P=0.088N     P=0.100N     P=0.180N     | 
|LOGISTIC REGRESSION|     P=0.102      P=0.484      P=0.456      P=0.141     |P=0.210N     P=0.092N     P=0.060N     P=0.219N     | 
|COCH-ARM / FISHERS |     P=0.143      P=0.500      P=0.500      P=0.194     |P=0.113N     P=0.105N     P=0.105N     P=0.105N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/43.62      1/43.44      0/41.35     |0/45.36      0/45.94      2/46.19      1/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |0.0%         0.0%         4.3%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      606          ---         |---          ---          476          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.623N     P=0.489      P=0.496      (e)         |P=0.208      (e)          P=0.256      P=0.465      | 
|POLY 3             |     P=0.615N     P=0.495      P=0.495      (e)         |P=0.199      (e)          P=0.241      P=0.477      | 
|POLY 1.5           |     P=0.609N     P=0.496      P=0.497      (e)         |P=0.215      (e)          P=0.241      P=0.485      | 
|POLY 6             |     P=0.622N     P=0.495      P=0.491      (e)         |P=0.185      (e)          P=0.242      P=0.470      | 
|LOGISTIC REGRESSION|     P=0.588N     P=0.489      P=0.496      (e)         |P=0.289      (e)          P=0.186      P=0.465      | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.246      (e)          P=0.247      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/50 (28%)  11/50 (22%)  9/50 (18%)   13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |14/46.78     11/47.45     9/46.77      13/42.10     | 
|POLY-3 PERCENT (g) |                                                        |29.9%        23.2%        19.2%        30.9%        | 
|TERMINAL (d)       |                                                        |11/37 (30%)  8/39 (21%)   7/41 (17%)   11/31 (36%)  | 
|FIRST INCIDENCE    |                                                        |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.417      P=0.287N     P=0.129N     P=0.482      | 
|POLY 3             |                                                        |P=0.491      P=0.306N     P=0.168N     P=0.553      | 
|POLY 1.5           |                                                        |P=0.530      P=0.311N     P=0.167N     P=0.582N     | 
|POLY 6             |                                                        |P=0.451      P=0.302N     P=0.170N     P=0.504      | 
|LOGISTIC REGRESSION|                                                        |P=0.453N     P=0.328N     P=0.175N     P=0.532N     | 
|COCH-ARM / FISHERS |                                                        |P=0.489N     P=0.322N     P=0.171N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/50 (28%)  11/50 (22%)  10/50 (20%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |14/46.78     11/47.45     10/47.21     13/42.10     | 
|POLY-3 PERCENT (g) |                                                        |29.9%        23.2%        21.2%        30.9%        | 
|TERMINAL (d)       |                                                        |11/37 (30%)  8/39 (21%)   7/41 (17%)   11/31 (36%)  | 
|FIRST INCIDENCE    |                                                        |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.404      P=0.287N     P=0.190N     P=0.482      | 
|POLY 3             |                                                        |P=0.475      P=0.306N     P=0.231N     P=0.553      | 
|POLY 1.5           |                                                        |P=0.516      P=0.311N     P=0.233N     P=0.582N     | 
|POLY 6             |                                                        |P=0.436      P=0.302N     P=0.229N     P=0.504      | 
|LOGISTIC REGRESSION|                                                        |P=0.455N     P=0.328N     P=0.248N     P=0.532N     | 
|COCH-ARM / FISHERS |                                                        |P=0.500N     P=0.322N     P=0.241N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.19      1/43.62      0/43.01      2/41.72     |0/45.36      1/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         4.8%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          729 (T)      ---          643         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.749      P=0.509N     P=0.469     |P=0.597N     P=0.511      (e)          (e)          | 
|POLY 3             |     P=0.350      P=0.753      P=0.510N     P=0.472     |P=0.568N     P=0.503      (e)          (e)          | 
|POLY 1.5           |     P=0.356      P=0.755      P=0.505N     P=0.481     |P=0.568N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.343      P=0.751      P=0.516N     P=0.463     |P=0.568N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.381      P=0.750N     P=0.521N     P=0.536     |(e)          P=0.511      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.61      1/43.62      0/43.01      2/41.72     |0/45.36      1/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         0.0%         4.8%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          729 (T)      ---          643         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553      P=0.514N     P=0.250N     P=0.661     |P=0.597N     P=0.511      (e)          (e)          | 
|POLY 3             |     P=0.574      P=0.516N     P=0.250N     P=0.662     |P=0.568N     P=0.503      (e)          (e)          | 
|POLY 1.5           |     P=0.580      P=0.511N     P=0.244N     P=0.672     |P=0.568N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.566      P=0.520N     P=0.259N     P=0.650     |P=0.568N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.615      P=0.472N     P=0.240N     P=0.655N    |(e)          P=0.511      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.591      P=0.500N     P=0.247N     P=0.691N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  14/50 (28%)  9/50 (18%)   17/50 (34%) |10/50 (20%)  11/50 (22%)  5/50 (10%)   16/50 (32%)  | 
|POLY-3 RATE (b)    |     11/46.82     14/46.02     9/44.61      17/44.18    |10/46.45     11/46.24     5/46.29      16/41.92     | 
|POLY-3 PERCENT (g) |     23.5%        30.4%        20.2%        38.5%       |21.5%        23.8%        10.8%        38.2%        | 
|TERMINAL (d)       |     5/37 (14%)   8/35 (23%)   4/33 (12%)   8/30 (27%)  |5/37 (14%)   8/39 (21%)   3/41 (7%)    10/31 (32%)  | 
|FIRST INCIDENCE    |     554          371          483          350         |554          671          536          601          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079      P=0.306      P=0.489N     P=0.081     |P=0.048 *    P=0.545      P=0.120N     P=0.064      | 
|POLY 3             |     P=0.101      P=0.303      P=0.448N     P=0.091     |P=0.069      P=0.495      P=0.131N     P=0.067      | 
|POLY 1.5           |     P=0.114      P=0.307      P=0.425N     P=0.103     |P=0.079      P=0.498      P=0.129N     P=0.083      | 
|POLY 6             |     P=0.089      P=0.297      P=0.480N     P=0.081     |P=0.062      P=0.492      P=0.134N     P=0.058      | 
|LOGISTIC REGRESSION|     P=0.155      P=0.341      P=0.385N     P=0.140     |P=0.074      P=0.507      P=0.133N     P=0.081      | 
|COCH-ARM / FISHERS |     P=0.142      P=0.322      P=0.402N     P=0.133     |P=0.109      P=0.500      P=0.131N     P=0.127      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.75      1/43.62      1/43.39      0/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         2.3%         2.3%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     699          729 (T)      624          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.198N     P=0.220N     P=0.094N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.036N*    P=0.186N     P=0.188N     P=0.071N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.035N*    P=0.185N     P=0.183N     P=0.067N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.037N*    P=0.187N     P=0.194N     P=0.075N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.186N     P=0.185N     P=0.078N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.181N     P=0.181N     P=0.059N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.75      1/43.62      1/43.39      0/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         2.3%         2.3%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     699          729 (T)      624          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.198N     P=0.220N     P=0.094N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.036N*    P=0.186N     P=0.188N     P=0.071N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.035N*    P=0.185N     P=0.183N     P=0.067N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.037N*    P=0.187N     P=0.194N     P=0.075N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.186N     P=0.185N     P=0.078N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.181N     P=0.181N     P=0.059N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  47/50 (94%)  49/50 (98%)  46/50 (92%) |45/50 (90%)  45/50 (90%)  43/50 (86%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     48/49.05     47/47.26     49/49.29     46/46.37    |45/48.50     45/49.11     43/47.88     44/46.15     | 
|POLY-3 PERCENT (g) |     97.9%        99.5%        99.4%        99.2%       |92.8%        91.6%        89.8%        95.3%        | 
|TERMINAL (d)       |     36/37 (97%)  35/35 (100%) 33/33 (100%) 30/30 (100%)|34/37 (92%)  35/39 (90%)  38/41 (93%)  30/31 (97%)  | 
|FIRST INCIDENCE    |     479          509          364          496         |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.107      P=0.492      P=0.186      P=0.166     |P=0.109      P=0.419N     P=0.156N     P=0.150      | 
|POLY 3             |     P=0.467      P=0.591      P=0.592      P=0.638     |P=0.374      P=0.567N     P=0.433N     P=0.461      | 
|POLY 1.5           |     P=0.677      P=0.711      P=0.609      P=0.791     |P=0.497      P=0.591N     P=0.386N     P=0.572      | 
|POLY 6             |     P=0.320      P=0.519      P=0.532      P=0.529     |P=0.292      P=0.538N     P=0.514N     P=0.392      | 
|LOGISTIC REGRESSION|     P=0.562      P=0.692      P=0.534      P=0.693     |P=0.366      P=0.619N     P=0.326N     P=0.404      | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.500N     P=0.500      P=0.339N    |P=0.397N     P=0.630N     P=0.380N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  23/50 (46%)  24/50 (48%)  30/50 (60%) |18/50 (36%)  19/50 (38%)  14/50 (28%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     21/49.07     23/46.83     24/46.67     30/45.67    |18/47.24     19/47.82     14/48.30     21/42.76     | 
|POLY-3 PERCENT (g) |     42.8%        49.1%        51.4%        65.7%       |38.1%        39.7%        29.0%        49.1%        | 
|TERMINAL (d)       |     10/37 (27%)  14/35 (40%)  13/33 (39%)  18/30 (60%) |10/37 (27%)  12/39 (31%)  8/41 (20%)   13/31 (42%)  | 
|FIRST INCIDENCE    |     259          371          483          350         |511          347          476          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.381      P=0.254      P=0.028 *   |P=0.166      P=0.556      P=0.227N     P=0.167      | 
|POLY 3             |     P=0.014 *    P=0.339      P=0.261      P=0.019 *   |P=0.223      P=0.519      P=0.234N     P=0.200      | 
|POLY 1.5           |     P=0.019 *    P=0.358      P=0.290      P=0.025 *   |P=0.256      P=0.515      P=0.240N     P=0.240      | 
|POLY 6             |     P=0.011 *    P=0.326      P=0.234      P=0.014 *   |P=0.204      P=0.522      P=0.229N     P=0.176      | 
|LOGISTIC REGRESSION|     P=0.042 *    P=0.452      P=0.386      P=0.064     |P=0.336      P=0.498      P=0.268N     P=0.247      | 
|COCH-ARM / FISHERS |     P=0.038 *    P=0.420      P=0.344      P=0.055     |P=0.345      P=0.500      P=0.260N     P=0.341      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 48/50 (96%)  50/50 (100%) 47/50 (94%) |47/50 (94%)  48/50 (96%)  48/50 (96%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     50/50.00     48/48.12     50/50.00     47/47.26    |47/49.06     48/50.00     48/49.29     44/46.15     | 
|POLY-3 PERCENT (g) |     100.0%       99.7%        100.0%       99.5%       |95.8%        96.0%        97.4%        95.3%        | 
|TERMINAL (d)       |     37/37 (100%) 35/35 (100%) 33/33 (100%) 30/30 (100%)|35/37 (95%)  37/39 (95%)  40/41 (98%)  30/31 (97%)  | 
|FIRST INCIDENCE    |     259          371          364          350         |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.142      P=0.567      (e)          P=0.215     |P=0.196      P=0.488N     P=0.350N     P=0.246      | 
|POLY 3             |     P=0.940N     P=1.000N     (e)          P=1.000N    |P=0.571N     P=0.676      P=0.551      P=0.663N     | 
|POLY 1.5           |     P=0.295N     P=0.935N     (e)          P=0.642N    |P=0.365N     P=0.642      P=0.562      P=0.485N     | 
|POLY 6             |     P=1.000N     P=1.000N     (e)          P=1.000N    |P=0.485      P=0.685      P=0.518      P=0.639      | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.336N     (e)          P=0.211N    |P=0.339N     P=0.511      P=0.586      P=0.585N     | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.247N     (e)          P=0.121N    |P=0.113N     P=0.500      P=0.500      P=0.243N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).