National Toxicology Program

National Toxicology Program
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TDMS Study 93023-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 03/14/01       
EXPERIMENT: 93023 TEST: 06                                                                                     TIME: 15:02:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 142-83-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  2,4-HEXADIENAL                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Stomach, Forestomach                   Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
Testes                                 Adenoma                                                                                      
Thyroid Gland: C-Cell                  Carcinoma                                                                                    
All Organs                             Mesothelioma: Benign, Malignant, NOS                                                         
                                       Mesothelioma: Malignant                                                                      
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Mammary Gland                          Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Stomach, Forestomach                   Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   2,4-HEXADIENAL          
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/49 (12%)   7/50 (14%)   7/49 (14%)  |1/50 (2%)    5/49 (10%)   5/50 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/45.23      6/42.62      7/44.04      7/40.62     |1/45.36      5/44.98      5/45.73      1/40.99      | 
|POLY-3 PERCENT (g) |     15.5%        14.1%        15.9%        17.2%       |2.2%         11.1%        10.9%        2.4%         | 
|TERMINAL (d)       |     5/37 (14%)   6/34 (18%)   5/33 (15%)   5/29 (17%)  |1/37 (3%)    4/38 (11%)   4/41 (10%)   0/31 (0%)    | 
|FIRST INCIDENCE    |     587          729 (T)      536          691         |729 (T)      719          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348      P=0.560N     P=0.534      P=0.444     |P=0.507N     P=0.113      P=0.125      P=0.731      | 
|POLY 3             |     P=0.437      P=0.546N     P=0.593      P=0.529     |P=0.493N     P=0.099      P=0.103      P=0.738      | 
|POLY 1.5           |     P=0.460      P=0.538N     P=0.604      P=0.551     |P=0.467N     P=0.098      P=0.103      P=0.745      | 
|POLY 6             |     P=0.412      P=0.554N     P=0.578      P=0.504     |P=0.516N     P=0.100      P=0.103      P=0.731      | 
|LOGISTIC REGRESSION|     P=0.439      P=0.536N     P=0.608      P=0.527     |P=0.458N     P=0.102      P=0.103      P=0.735N     | 
|COCH-ARM / FISHERS |     P=0.503      P=0.516N     P=0.613N     P=0.597     |P=0.417N     P=0.098      P=0.102      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    1/50 (2%)    4/49 (8%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/42.62      1/43.01      4/41.03     |1/45.36      0/44.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.3%         9.8%        |2.2%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/34 (3%)    1/33 (3%)    3/29 (10%)  |1/37 (3%)    0/38 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      496         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.483      P=0.477      P=0.043 *   |P=0.564      P=0.495N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.014 *    P=0.491      P=0.493      P=0.050     |P=0.578      P=0.502N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.015 *    P=0.492      P=0.496      P=0.052     |P=0.584      P=0.503N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.013 *    P=0.491      P=0.488      P=0.047 *   |P=0.572      P=0.501N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.483      P=0.477      P=0.061     |P=0.564      (e)          (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.017 *    P=0.495      P=0.500      P=0.056     |P=0.596      P=0.505N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   8/49 (16%)   9/50 (18%)   11/49 (22%) |2/50 (4%)    5/49 (10%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/45.23      8/42.84      9/44.26      11/41.31    |2/45.36      5/44.98      5/45.73      3/41.23      | 
|POLY-3 PERCENT (g) |     15.5%        18.7%        20.3%        26.6%       |4.4%         11.1%        10.9%        7.3%         | 
|TERMINAL (d)       |     5/37 (14%)   7/34 (21%)   6/33 (18%)   8/29 (28%)  |2/37 (5%)    4/38 (11%)   4/41 (10%)   1/31 (3%)    | 
|FIRST INCIDENCE    |     587          671          536          496         |729 (T)      719          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.073      P=0.438      P=0.318      P=0.107     |P=0.418      P=0.232      P=0.254      P=0.431      | 
|POLY 3             |     P=0.118      P=0.454      P=0.373      P=0.155     |P=0.446      P=0.213      P=0.219      P=0.457      | 
|POLY 1.5           |     P=0.130      P=0.461      P=0.384      P=0.170     |P=0.470      P=0.211      P=0.220      P=0.471      | 
|POLY 6             |     P=0.105      P=0.449      P=0.360      P=0.140     |P=0.426      P=0.215      P=0.220      P=0.445      | 
|LOGISTIC REGRESSION|     P=0.121      P=0.462      P=0.386      P=0.162     |P=0.473      P=0.216      P=0.216      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.156      P=0.483      P=0.393      P=0.204     |P=0.522      P=0.210      P=0.218      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Astrocytoma Malignant                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      1/41.62     |2/46.02      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          655         |511          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184      (e)          (e)          P=0.480     |P=0.123N     P=0.234N     P=0.228N     P=0.272N     | 
|POLY 3             |     P=0.191      (e)          (e)          P=0.486     |P=0.109N     P=0.238N     P=0.240N     P=0.267N     | 
|POLY 1.5           |     P=0.193      (e)          (e)          P=0.490     |P=0.110N     P=0.238N     P=0.238N     P=0.257N     | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.482     |P=0.107N     P=0.237N     P=0.242N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.205      (e)          (e)          P=0.512     |P=0.092N     P=0.242N     P=0.264N     P=0.192N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      1/41.62     |2/46.02      1/46.83      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |4.4%         2.1%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          655         |511          347          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184      (e)          (e)          P=0.480     |P=0.169N     P=0.494N     P=0.476N     P=0.272N     | 
|POLY 3             |     P=0.191      (e)          (e)          P=0.486     |P=0.172N     P=0.494N     P=0.504N     P=0.267N     | 
|POLY 1.5           |     P=0.193      (e)          (e)          P=0.490     |P=0.166N     P=0.496N     P=0.501N     P=0.257N     | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.482     |P=0.178N     P=0.493N     P=0.507N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.205      (e)          (e)          P=0.512     |P=0.091N     P=0.515N     P=0.521N     P=0.192N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    4/50 (8%)    0/50 (0%)    1/50 (2%)   |5/50 (10%)   8/50 (16%)   11/50 (22%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/43.75      4/43.62      0/43.01      1/41.35     |5/45.36      8/46.36      11/45.91     7/40.54      | 
|POLY-3 PERCENT (g) |     2.3%         9.2%         0.0%         2.4%        |11.0%        17.3%        24.0%        17.3%        | 
|TERMINAL (d)       |     1/37 (3%)    4/35 (11%)   0/33 (0%)    1/30 (3%)   |5/37 (14%)   7/39 (18%)   10/41 (24%)  6/31 (19%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      610          602          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.162      P=0.523N     P=0.715     |P=0.215      P=0.310      P=0.122      P=0.259      | 
|POLY 3             |     P=0.355N     P=0.177      P=0.503N     P=0.748     |P=0.242      P=0.290      P=0.087      P=0.302      | 
|POLY 1.5           |     P=0.347N     P=0.179      P=0.500N     P=0.753     |P=0.279      P=0.284      P=0.087      P=0.328      | 
|POLY 6             |     P=0.365N     P=0.176      P=0.509N     P=0.742     |P=0.212      P=0.297      P=0.087      P=0.280      | 
|LOGISTIC REGRESSION|     P=0.407N     P=0.162      (e)          P=0.715     |P=0.234      P=0.285      P=0.084      P=0.248      | 
|COCH-ARM / FISHERS |     P=0.332N     P=0.187      P=0.495N     P=0.747N    |P=0.358      P=0.277      P=0.086      P=0.380      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/50 (6%)    5/50 (10%)   1/50 (2%)   |2/50 (4%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/45.06      3/43.94      5/43.57      1/41.88     |2/45.49      1/45.94      3/45.47      3/40.54      | 
|POLY-3 PERCENT (g) |     6.7%         6.8%         11.5%        2.4%        |4.4%         2.2%         6.6%         7.4%         | 
|TERMINAL (d)       |     1/37 (3%)    1/35 (3%)    3/33 (9%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    3/41 (7%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     259          671          620          566         |704          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340N     P=0.647      P=0.316      P=0.339N    |P=0.222      P=0.491N     P=0.530      P=0.405      | 
|POLY 3             |     P=0.313N     P=0.651      P=0.338      P=0.332N    |P=0.251      P=0.497N     P=0.500      P=0.448      | 
|POLY 1.5           |     P=0.298N     P=0.654      P=0.349      P=0.322N    |P=0.268      P=0.498N     P=0.502      P=0.466      | 
|POLY 6             |     P=0.330N     P=0.650      P=0.324      P=0.342N    |P=0.236      P=0.495N     P=0.497      P=0.431      | 
|LOGISTIC REGRESSION|     P=0.232N     P=0.613N     P=0.378      P=0.183N    |P=0.235      P=0.495N     P=0.500      P=0.439      | 
|COCH-ARM / FISHERS |     P=0.266N     P=0.651N     P=0.369      P=0.301N    |P=0.302      P=0.500N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    7/50 (14%)   5/50 (10%)   2/50 (4%)   |7/50 (14%)   9/50 (18%)   14/50 (28%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     4/45.06      7/43.94      5/43.57      2/41.88     |7/45.49      9/46.36      14/45.91     10/40.69     | 
|POLY-3 PERCENT (g) |     8.9%         15.9%        11.5%        4.8%        |15.4%        19.4%        30.5%        24.6%        | 
|TERMINAL (d)       |     2/37 (5%)    5/35 (14%)   3/33 (9%)    1/30 (3%)   |5/37 (14%)   8/39 (21%)   13/41 (32%)  8/31 (26%)   | 
|FIRST INCIDENCE    |     259          671          620          566         |704          610          602          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.246      P=0.446      P=0.399N    |P=0.110      P=0.434      P=0.110      P=0.172      | 
|POLY 3             |     P=0.218N     P=0.246      P=0.479      P=0.371N    |P=0.135      P=0.408      P=0.069      P=0.212      | 
|POLY 1.5           |     P=0.204N     P=0.251      P=0.492      P=0.359N    |P=0.166      P=0.402      P=0.070      P=0.240      | 
|POLY 6             |     P=0.235N     P=0.244      P=0.464      P=0.385N    |P=0.112      P=0.415      P=0.068      P=0.190      | 
|LOGISTIC REGRESSION|     P=0.165N     P=0.285      P=0.527      P=0.247N    |P=0.123      P=0.405      P=0.067      P=0.173      | 
|COCH-ARM / FISHERS |     P=0.172N     P=0.274      P=0.513      P=0.329N    |P=0.237      P=0.393      P=0.070      P=0.298      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   5/50 (10%)   1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.19      6/44.23      5/43.01      1/41.35     |1/45.37      1/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         13.6%        11.6%        2.4%        |2.2%         2.2%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    3/35 (9%)    5/33 (15%)   1/30 (3%)   |0/37 (0%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          659          729 (T)      729 (T)     |727          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169N     P=0.355      P=0.433      P=0.238N    |P=0.347N     P=0.752N     P=0.740N     P=0.541N     | 
|POLY 3             |     P=0.141N     P=0.356      P=0.469      P=0.207N    |P=0.337N     P=0.758N     P=0.760N     P=0.523N     | 
|POLY 1.5           |     P=0.129N     P=0.357      P=0.484      P=0.197N    |P=0.329N     P=0.759N     P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.156N     P=0.359      P=0.449      P=0.217N    |P=0.345N     P=0.757N     P=0.760      P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.128N     P=0.364      P=0.476      P=0.189N    |P=0.354N     P=0.756N     P=0.759N     P=0.541N     | 
|COCH-ARM / FISHERS |     P=0.109N     P=0.370      P=0.500      P=0.181N    |P=0.311N     P=0.753N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      2/43.72      0/43.01      1/41.35     |0/45.36      1/46.19      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         2.4%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          704          ---          729 (T)     |---          664          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.234      (e)          P=0.458     |P=0.597N     P=0.505      (e)          (e)          | 
|POLY 3             |     P=0.511      P=0.232      (e)          P=0.485     |P=0.568N     P=0.504      (e)          (e)          | 
|POLY 1.5           |     P=0.520      P=0.233      (e)          P=0.490     |P=0.568N     P=0.502      (e)          (e)          | 
|POLY 6             |     P=0.501      P=0.233      (e)          P=0.479     |P=0.567N     P=0.506      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.508      P=0.232      (e)          P=0.458     |P=0.551N     P=0.497      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   5/50 (10%)   2/50 (4%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.19      7/44.23      5/43.01      2/41.35     |1/45.37      2/46.19      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         15.8%        11.6%        4.8%        |2.2%         4.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    4/35 (11%)   5/33 (15%)   2/30 (7%)   |0/37 (0%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          659          729 (T)      729 (T)     |727          664          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268N     P=0.250      P=0.433      P=0.424N    |P=0.285N     P=0.512      P=0.740N     P=0.541N     | 
|POLY 3             |     P=0.226N     P=0.248      P=0.469      P=0.379N    |P=0.276N     P=0.506      P=0.760N     P=0.523N     | 
|POLY 1.5           |     P=0.209N     P=0.250      P=0.484      P=0.365N    |P=0.266N     P=0.504      P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.247N     P=0.250      P=0.449      P=0.395N    |P=0.285N     P=0.510      P=0.760      P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.212N     P=0.255      P=0.476      P=0.360N    |P=0.269N     P=0.502      P=0.759N     P=0.541N     | 
|COCH-ARM / FISHERS |     P=0.179N     P=0.262      P=0.500      P=0.339N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    4/50 (8%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      0/43.62      4/43.89      1/41.35     |3/45.46      1/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         9.1%         2.4%        |6.6%         2.2%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    3/33 (9%)    1/30 (3%)   |2/37 (5%)    1/39 (3%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          364          729 (T)     |704          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381      P=0.511N     P=0.156      P=0.715     |P=0.088N     P=0.293N     P=0.282N     P=0.162N     | 
|POLY 3             |     P=0.400      P=0.505N     P=0.173      P=0.744     |P=0.082N     P=0.302N     P=0.305N     P=0.141N     | 
|POLY 1.5           |     P=0.414      P=0.504N     P=0.177      P=0.749     |P=0.079N     P=0.303N     P=0.304N     P=0.133N     | 
|POLY 6             |     P=0.384      P=0.505N     P=0.167      P=0.738     |P=0.085N     P=0.300N     P=0.307N     P=0.149N     | 
|LOGISTIC REGRESSION|     P=0.456      (e)          P=0.184      P=0.715     |P=0.088N     P=0.298N     P=0.304N     P=0.149N     | 
|COCH-ARM / FISHERS |     P=0.444      P=0.500N     P=0.181      P=0.753N    |P=0.073N     P=0.309N     P=0.309N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      3/43.01      1/41.35     |0/45.36      0/45.94      1/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.0%         2.4%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    3/33 (9%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      (e)          P=0.101      P=0.458     |P=0.679      (e)          P=0.520      (e)          | 
|POLY 3             |     P=0.214      (e)          P=0.112      P=0.485     |P=0.639      (e)          P=0.500      (e)          | 
|POLY 1.5           |     P=0.224      (e)          P=0.115      P=0.490     |P=0.659      (e)          P=0.501      (e)          | 
|POLY 6             |     P=0.203      (e)          P=0.107      P=0.479     |P=0.620      (e)          P=0.500      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.101      P=0.458     |(e)          (e)          P=0.520      (e)          | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   2/50 (4%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      0/43.62      6/43.89      2/41.35     |3/45.46      1/45.94      2/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         13.7%        4.8%        |6.6%         2.2%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    5/33 (15%)   2/30 (7%)   |2/37 (5%)    1/39 (3%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          364          729 (T)     |704          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165      P=0.511N     P=0.045 *    P=0.427     |P=0.128N     P=0.293N     P=0.465N     P=0.162N     | 
|POLY 3             |     P=0.184      P=0.505N     P=0.053      P=0.473     |P=0.123N     P=0.302N     P=0.500N     P=0.141N     | 
|POLY 1.5           |     P=0.196      P=0.504N     P=0.055      P=0.482     |P=0.116N     P=0.303N     P=0.498N     P=0.133N     | 
|POLY 6             |     P=0.170      P=0.505N     P=0.049 *    P=0.464     |P=0.129N     P=0.300N     P=0.502N     P=0.149N     | 
|LOGISTIC REGRESSION|     P=0.220      (e)          P=0.060      P=0.427     |P=0.128N     P=0.298N     P=0.500N     P=0.149N     | 
|COCH-ARM / FISHERS |     P=0.227      P=0.500N     P=0.056      P=0.500     |P=0.104N     P=0.309N     P=0.500N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      0/43.01      0/41.35     |2/45.43      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |712          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.126N     P=0.229N     P=0.226N     P=0.285N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.235N     P=0.237N     P=0.264N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.236N     P=0.236N     P=0.255N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.234N     P=0.238N     P=0.274N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.124N     P=0.234N     P=0.237N     P=0.272N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.73      0/43.62      0/43.01      0/41.35     |2/45.53      3/45.98      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |4.4%         6.5%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    2/39 (5%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     704          ---          ---          ---         |704          719          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.246N     P=0.265N     P=0.279N    |P=0.297N     P=0.520      P=0.240N     P=0.577N     | 
|POLY 3             |     P=0.110N     P=0.243N     P=0.246N     P=0.255N    |P=0.260N     P=0.505      P=0.237N     P=0.542N     | 
|POLY 1.5           |     P=0.111N     P=0.242N     P=0.242N     P=0.249N    |P=0.254N     P=0.503      P=0.237N     P=0.527N     | 
|POLY 6             |     P=0.110N     P=0.243N     P=0.252N     P=0.262N    |P=0.266N     P=0.506      P=0.239N     P=0.556N     | 
|LOGISTIC REGRESSION|     P=0.123N     P=0.242N     P=0.250N     P=0.259N    |P=0.282N     P=0.507      P=0.237N     P=0.547N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.242N     P=0.500      P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.73      0/43.62      0/43.01      0/41.35     |3/45.53      3/45.98      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |6.6%         6.5%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    2/39 (5%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     704          ---          ---          ---         |704          719          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.246N     P=0.265N     P=0.279N    |P=0.173N     P=0.638N     P=0.118N     P=0.385N     | 
|POLY 3             |     P=0.110N     P=0.243N     P=0.246N     P=0.255N    |P=0.147N     P=0.658N     P=0.119N     P=0.349N     | 
|POLY 1.5           |     P=0.111N     P=0.242N     P=0.242N     P=0.249N    |P=0.142N     P=0.659N     P=0.118N     P=0.334N     | 
|POLY 6             |     P=0.110N     P=0.243N     P=0.252N     P=0.262N    |P=0.151N     P=0.656N     P=0.120N     P=0.365N     | 
|LOGISTIC REGRESSION|     P=0.123N     P=0.242N     P=0.250N     P=0.259N    |P=0.164N     P=0.656N     P=0.120N     P=0.359N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.134N     P=0.661N     P=0.121N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |22/50 (44%)  28/50 (56%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     3/44.63      1/43.62      1/43.40      2/41.75     |22/47.24     28/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         4.8%        |46.6%        59.3%        48.1%        42.5%        | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |16/37 (43%)  23/39 (59%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541N     P=0.325N     P=0.340N     P=0.580N    |P=0.349N     P=0.243      P=0.431N     P=0.529N     | 
|POLY 3             |     P=0.486N     P=0.313N     P=0.315N     P=0.530N    |P=0.249N     P=0.148      P=0.524      P=0.432N     | 
|POLY 1.5           |     P=0.482N     P=0.312N     P=0.310N     P=0.522N    |P=0.193N     P=0.151      P=0.554      P=0.373N     | 
|POLY 6             |     P=0.491N     P=0.313N     P=0.322N     P=0.539N    |P=0.306N     P=0.145      P=0.485      P=0.486N     | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.325N     P=0.312N     P=0.534N    |P=0.229N     P=0.164      P=0.577N     P=0.374N     | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.309N     P=0.309N     P=0.500N    |P=0.115N     P=0.159      P=0.580N     P=0.270N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |23/50 (46%)  28/50 (56%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     3/44.63      1/43.62      1/43.40      2/41.75     |23/47.24     28/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         4.8%        |48.7%        59.3%        48.1%        42.5%        | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |17/37 (46%)  23/39 (59%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541N     P=0.325N     P=0.340N     P=0.580N    |P=0.293N     P=0.305      P=0.353N     P=0.461N     | 
|POLY 3             |     P=0.486N     P=0.313N     P=0.315N     P=0.530N    |P=0.197N     P=0.201      P=0.560N     P=0.355N     | 
|POLY 1.5           |     P=0.482N     P=0.312N     P=0.310N     P=0.522N    |P=0.149N     P=0.204      P=0.529N     P=0.299N     | 
|POLY 6             |     P=0.491N     P=0.313N     P=0.322N     P=0.539N    |P=0.247N     P=0.198      P=0.566      P=0.407N     | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.325N     P=0.312N     P=0.534N    |P=0.182N     P=0.220      P=0.496N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.309N     P=0.309N     P=0.500N    |P=0.086N     P=0.212      P=0.500N     P=0.208N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    1/50 (2%)    2/50 (4%)   |24/50 (48%)  30/50 (60%)  22/50 (44%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     5/44.73      1/43.62      1/43.40      2/41.75     |24/47.34     30/47.18     22/45.73     18/42.31     | 
|POLY-3 PERCENT (g) |     11.2%        2.3%         2.3%         4.8%        |50.7%        63.6%        48.1%        42.5%        | 
|TERMINAL (d)       |     4/37 (11%)   1/35 (3%)    0/33 (0%)    0/30 (0%)   |17/37 (46%)  25/39 (64%)  21/41 (51%)  12/31 (39%)  | 
|FIRST INCIDENCE    |     704          729 (T)      620          655         |511          544          659          445          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.116N     P=0.131N     P=0.298N    |P=0.208N     P=0.251      P=0.289N     P=0.399N     | 
|POLY 3             |     P=0.199N     P=0.107N     P=0.108N     P=0.244N    |P=0.123N     P=0.143      P=0.483N     P=0.287N     | 
|POLY 1.5           |     P=0.196N     P=0.106N     P=0.105N     P=0.236N    |P=0.088N     P=0.147      P=0.449N     P=0.235N     | 
|POLY 6             |     P=0.203N     P=0.107N     P=0.112N     P=0.253N    |P=0.164N     P=0.137      P=0.528N     P=0.338N     | 
|LOGISTIC REGRESSION|     P=0.209N     P=0.108N     P=0.110N     P=0.249N    |P=0.113N     P=0.164      P=0.415N     P=0.239N     | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.102N     P=0.102N     P=0.218N    |P=0.047N*    P=0.158      P=0.421N     P=0.156N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.97      1/43.62      2/43.69      1/41.35     |1/45.39      0/45.94      2/46.19      1/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         4.6%         2.4%        |2.2%         0.0%         4.3%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    1/30 (3%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     634          729 (T)      606          729 (T)     |722          ---          476          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.544      P=0.757      P=0.483      P=0.729     |P=0.448      P=0.495N     P=0.522      P=0.715      | 
|POLY 3             |     P=0.554      P=0.754      P=0.490      P=0.742     |P=0.445      P=0.498N     P=0.506      P=0.734      | 
|POLY 1.5           |     P=0.566      P=0.755      P=0.495      P=0.748     |P=0.464      P=0.499N     P=0.505      P=0.743      | 
|POLY 6             |     P=0.539      P=0.753      P=0.483      P=0.734     |P=0.427      P=0.497N     P=0.507      P=0.725      | 
|LOGISTIC REGRESSION|     P=0.598      P=0.761N     P=0.504      P=0.763     |P=0.534      P=0.496N     P=0.469      P=0.720      | 
|COCH-ARM / FISHERS |     P=0.591      P=0.753N     P=0.500      P=0.753N    |P=0.500      P=0.500N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  5/50 (10%)   9/50 (18%)   6/50 (12%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/44.85     5/43.62      9/43.18      6/41.35     |1/45.36      0/45.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     22.3%        11.5%        20.8%        14.5%       |2.2%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     8/37 (22%)   5/35 (14%)   8/33 (24%)   6/30 (20%)  |1/37 (3%)    0/39 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     699          729 (T)      686          729 (T)     |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.435N     P=0.156N     P=0.590      P=0.352N    |P=0.562      P=0.489N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.326N     P=0.140N     P=0.537N     P=0.257N    |P=0.576      P=0.497N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.307N     P=0.139N     P=0.519N     P=0.240N    |P=0.583      P=0.499N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.350N     P=0.141N     P=0.563N     P=0.279N    |P=0.571      P=0.496N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.390N     P=0.139N     P=0.585N     P=0.303N    |P=0.562      (e)          (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.273N     P=0.131N     P=0.500N     P=0.207N    |P=0.595      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  16/50 (32%)  15/50 (30%)  19/50 (38%) |19/50 (38%)  26/50 (52%)  22/50 (44%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     12/46.24     16/45.27     15/44.33     19/43.17    |19/46.82     26/47.13     22/46.58     20/41.81     | 
|POLY-3 PERCENT (g) |     26.0%        35.3%        33.8%        44.0%       |40.6%        55.2%        47.2%        47.8%        | 
|TERMINAL (d)       |     8/37 (22%)   10/35 (29%)  10/33 (30%)  12/30 (40%) |12/37 (32%)  21/39 (54%)  19/41 (46%)  15/31 (48%)  | 
|FIRST INCIDENCE    |     542          537          560          574         |560          610          602          560          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.039 *    P=0.234      P=0.239      P=0.043 *   |P=0.321      P=0.186      P=0.466      P=0.260      | 
|POLY 3             |     P=0.055      P=0.227      P=0.277      P=0.055     |P=0.399      P=0.111      P=0.330      P=0.318      | 
|POLY 1.5           |     P=0.067      P=0.230      P=0.299      P=0.065     |P=0.477      P=0.111      P=0.341      P=0.379      | 
|POLY 6             |     P=0.046 *    P=0.230      P=0.251      P=0.048 *   |P=0.331      P=0.111      P=0.315      P=0.266      | 
|LOGISTIC REGRESSION|     P=0.071      P=0.244      P=0.313      P=0.072     |P=0.423      P=0.119      P=0.346      P=0.334      | 
|COCH-ARM / FISHERS |     P=0.098      P=0.252      P=0.326      P=0.097     |P=0.452N     P=0.114      P=0.342      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/47 (4%)    3/50 (6%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     2/43.63      2/40.96      3/43.01      3/41.35     |                                                    | 
|POLY-3 PERCENT (g) |     4.6%         4.9%         7.0%         7.3%        |                                                    | 
|TERMINAL (d)       |     2/36 (6%)    2/33 (6%)    3/33 (9%)    3/30 (10%)  |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.664      P=0.460      P=0.417     |                                                    | 
|POLY 3             |     P=0.352      P=0.671      P=0.494      P=0.475     |                                                    | 
|POLY 1.5           |     P=0.365      P=0.672      P=0.501      P=0.486     |                                                    | 
|POLY 6             |     P=0.337      P=0.673      P=0.483      P=0.464     |                                                    | 
|LOGISTIC REGRESSION|     P=0.294      P=0.664      P=0.460      P=0.417     |                                                    | 
|COCH-ARM / FISHERS |     P=0.389      P=0.676      P=0.510      P=0.510     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.63      2/43.62      3/43.01      2/41.35     |1/45.36      0/45.94      1/45.73      0/40.39      | 
|POLY-3 PERCENT (g) |     11.2%        4.6%         7.0%         4.8%        |2.2%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     5/37 (14%)   2/35 (6%)    3/33 (9%)    2/30 (7%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          659          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.238N     P=0.420N     P=0.307N    |P=0.441N     P=0.489N     P=0.752N     P=0.535N     | 
|POLY 3             |     P=0.233N     P=0.225N     P=0.376N     P=0.248N    |P=0.423N     P=0.497N     P=0.759N     P=0.523N     | 
|POLY 1.5           |     P=0.225N     P=0.224N     P=0.367N     P=0.238N    |P=0.417N     P=0.499N     P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.243N     P=0.224N     P=0.390N     P=0.259N    |P=0.429N     P=0.496N     P=0.759N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.238N     P=0.420N     P=0.307N    |P=0.408N     (e)          P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.210N     P=0.218N     P=0.357N     P=0.218N    |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    6/50 (12%)   5/50 (10%)  |2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/45.11      3/43.93      6/43.69      5/41.95     |2/45.61      0/45.94      1/45.47      2/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         6.8%         13.7%        11.9%       |4.4%         0.0%         2.2%         5.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/35 (6%)    5/33 (15%)   3/30 (10%)  |1/37 (3%)    0/39 (0%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     587          643          503          636         |664          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.521N     P=0.313      P=0.400     |P=0.408      P=0.231N     P=0.479N     P=0.629      | 
|POLY 3             |     P=0.293      P=0.514N     P=0.349      P=0.454     |P=0.435      P=0.236N     P=0.501N     P=0.649      | 
|POLY 1.5           |     P=0.308      P=0.512N     P=0.360      P=0.468     |P=0.447      P=0.236N     P=0.499N     P=0.665      | 
|POLY 6             |     P=0.278      P=0.515N     P=0.333      P=0.441     |P=0.425      P=0.235N     P=0.504N     P=0.634      | 
|LOGISTIC REGRESSION|     P=0.317      P=0.505N     P=0.367      P=0.476     |P=0.425      P=0.238N     P=0.499N     P=0.651      | 
|COCH-ARM / FISHERS |     P=0.338      P=0.500N     P=0.370      P=0.500     |P=0.469      P=0.247N     P=0.500N     P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/50 (8%)    7/50 (14%)   5/50 (10%)  |2/50 (4%)    1/50 (2%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/45.11      4/44.03      7/43.69      5/41.95     |2/45.61      1/45.97      2/45.73      3/40.99      | 
|POLY-3 PERCENT (g) |     15.5%        9.1%         16.0%        11.9%       |4.4%         2.2%         4.4%         7.3%         | 
|TERMINAL (d)       |     6/37 (16%)   2/35 (6%)    6/33 (18%)   3/30 (10%)  |1/37 (3%)    0/39 (0%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     587          643          503          636         |664          722          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.558N     P=0.289N     P=0.534      P=0.506N    |P=0.245      P=0.488N     P=0.678N     P=0.429      | 
|POLY 3             |     P=0.474N     P=0.274N     P=0.589      P=0.431N    |P=0.274      P=0.497N     P=0.693N     P=0.452      | 
|POLY 1.5           |     P=0.458N     P=0.273N     P=0.602      P=0.415N    |P=0.287      P=0.498N     P=0.692N     P=0.468      | 
|POLY 6             |     P=0.493N     P=0.273N     P=0.570      P=0.446N    |P=0.262      P=0.496N     P=0.694      P=0.436      | 
|LOGISTIC REGRESSION|     P=0.463N     P=0.271N     P=0.597      P=0.422N    |P=0.315      P=0.499N     P=0.694      P=0.501      | 
|COCH-ARM / FISHERS |     P=0.426N     P=0.262N     P=0.613N     P=0.380N    |P=0.313      P=0.500N     P=0.691N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.63      1/43.72      1/43.01      0/41.35     |0/45.36      1/45.97      0/45.47      1/40.99      | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         0.0%        |0.0%         2.2%         0.0%         2.4%         | 
|TERMINAL (d)       |     3/37 (8%)    0/35 (0%)    1/33 (3%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      704          729 (T)      ---         |---          722          ---          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.322N     P=0.346N     P=0.160N    |P=0.370      P=0.505      (e)          P=0.482      | 
|POLY 3             |     P=0.078N     P=0.313N     P=0.318N     P=0.133N    |P=0.380      P=0.503      (e)          P=0.480      | 
|POLY 1.5           |     P=0.076N     P=0.312N     P=0.312N     P=0.128N    |P=0.388      P=0.502      (e)          P=0.487      | 
|POLY 6             |     P=0.080N     P=0.311N     P=0.327N     P=0.138N    |P=0.373      P=0.504      (e)          P=0.474      | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.313N     P=0.346N     (e)         |P=0.460      P=0.504      (e)          P=0.586      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.309N     P=0.309N     P=0.121N    |P=0.405      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.63      1/43.72      1/43.01      0/41.35     |0/45.36      1/45.97      1/45.73      1/40.99      | 
|POLY-3 PERCENT (g) |     6.7%         2.3%         2.3%         0.0%        |0.0%         2.2%         2.2%         2.4%         | 
|TERMINAL (d)       |     3/37 (8%)    0/35 (0%)    1/33 (3%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      704          729 (T)      ---         |---          722          659          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.322N     P=0.346N     P=0.160N    |P=0.339      P=0.505      P=0.495      P=0.482      | 
|POLY 3             |     P=0.078N     P=0.313N     P=0.318N     P=0.133N    |P=0.345      P=0.503      P=0.502      P=0.480      | 
|POLY 1.5           |     P=0.076N     P=0.312N     P=0.312N     P=0.128N    |P=0.358      P=0.502      P=0.502      P=0.487      | 
|POLY 6             |     P=0.080N     P=0.311N     P=0.327N     P=0.138N    |P=0.333      P=0.504      P=0.502      P=0.474      | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.313N     P=0.346N     (e)         |P=0.440      P=0.504      P=0.489      P=0.586      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.309N     P=0.309N     P=0.121N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.63      2/43.62      1/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     6.7%         4.6%         2.3%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/35 (6%)    1/33 (3%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.526N     P=0.346N     P=0.382N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.214N     P=0.510N     P=0.318N     P=0.333N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.209N     P=0.509N     P=0.312N     P=0.324N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.221N     P=0.511N     P=0.327N     P=0.343N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.526N     P=0.346N     P=0.382N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.309N     P=0.309N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Neural Crest Tumor                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      1/44.28      0/43.01      2/41.35     |0/45.36      0/45.94      2/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         4.8%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/35 (0%)    0/33 (0%)    2/30 (7%)   |0/37 (0%)    0/39 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      509          ---          729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.752      P=0.523N     P=0.427     |P=0.562      (e)          P=0.261      (e)          | 
|POLY 3             |     P=0.349      P=0.759      P=0.507N     P=0.473     |P=0.524      (e)          P=0.238      (e)          | 
|POLY 1.5           |     P=0.356      P=0.758      P=0.504N     P=0.482     |P=0.549      (e)          P=0.238      (e)          | 
|POLY 6             |     P=0.342      P=0.760      P=0.512N     P=0.464     |P=0.500      (e)          P=0.237      (e)          | 
|LOGISTIC REGRESSION|     P=0.371      P=0.743N     (e)          P=0.427     |(e)          (e)          P=0.261      (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/43.96      0/43.01      0/41.35     |0/45.36      0/45.94      2/46.05      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          634          ---          ---         |---          ---          544          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581N     P=0.505      (e)          (e)         |P=0.567      (e)          P=0.251      (e)          | 
|POLY 3             |     P=0.574N     P=0.497      (e)          (e)         |P=0.522      (e)          P=0.241      (e)          | 
|POLY 1.5           |     P=0.572N     P=0.497      (e)          (e)         |P=0.548      (e)          P=0.240      (e)          | 
|POLY 6             |     P=0.577N     P=0.498      (e)          (e)         |P=0.497      (e)          P=0.241      (e)          | 
|LOGISTIC REGRESSION|     P=0.551N     P=0.515      (e)          (e)         |P=0.639      (e)          P=0.210      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.63      2/43.62      2/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     9.0%         4.6%         4.7%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/37 (11%)   2/35 (6%)    2/33 (6%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.151N     P=0.348N     P=0.354N     P=0.202N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.146N     P=0.346N     P=0.346N     P=0.195N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.158N     P=0.347N     P=0.366N     P=0.211N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.339N     P=0.339N     P=0.181N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.63      2/43.62      2/43.01      1/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     9.0%         4.6%         4.7%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/37 (11%)   2/35 (6%)    2/33 (6%)    1/30 (3%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.151N     P=0.348N     P=0.354N     P=0.202N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.146N     P=0.346N     P=0.346N     P=0.195N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.158N     P=0.347N     P=0.366N     P=0.211N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.189N     P=0.362N     P=0.390N     P=0.247N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.339N     P=0.339N     P=0.181N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.63      0/43.62      1/43.01      2/41.35     |0/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/35 (0%)    1/33 (3%)    2/30 (7%)   |0/37 (0%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051      (e)          P=0.477      P=0.193     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.063      (e)          P=0.493      P=0.220     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.065      (e)          P=0.496      P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.060      (e)          P=0.488      P=0.215     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.477      P=0.193     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    11/50 (22%)  29/50 (58%) |0/50 (0%)    1/50 (2%)    5/50 (10%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     0/44.63      3/43.62      11/43.16     29/43.31    |0/45.36      1/45.94      5/45.47      17/40.57     | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         25.5%        67.0%       |0.0%         2.2%         11.0%        41.9%        | 
|TERMINAL (d)       |     0/37 (0%)    3/35 (9%)    10/33 (30%)  23/30 (77%) |0/37 (0%)    1/39 (3%)    5/41 (12%)   15/31 (48%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      691          574         |---          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.503      P=0.031 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.115      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.501      P=0.031 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.504      P=0.030 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    10/50 (20%)  29/50 (58%) |0/50 (0%)    1/50 (2%)    5/50 (10%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     0/44.63      3/43.62      10/43.16     29/43.31    |0/45.36      1/45.94      5/45.47      17/40.57     | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         23.2%        67.0%       |0.0%         2.2%         11.0%        41.9%        | 
|TERMINAL (d)       |     0/37 (0%)    3/35 (9%)    9/33 (27%)   23/30 (77%) |0/37 (0%)    1/39 (3%)    5/41 (12%)   15/31 (48%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      691          574         |---          729 (T)      729 (T)      691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.503      P=0.031 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.115      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.501      P=0.031 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.504      P=0.030 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.511      P=0.043 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  45/50 (90%)  45/50 (90%)  46/50 (92%) |                                                    | 
|POLY-3 RATE (b)    |     41/47.06     45/46.90     45/47.72     46/46.37    |                                                    | 
|POLY-3 PERCENT (g) |     87.1%        96.0%        94.3%        99.2%       |                                                    | 
|TERMINAL (d)       |     33/37 (89%)  35/35 (100%) 32/33 (97%)  30/30 (100%)|                                                    | 
|FIRST INCIDENCE    |     479          509          503          496         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.144      P=0.072      P=0.013 *   |                                                    | 
|POLY 3             |     P=0.012 *    P=0.098      P=0.175      P=0.015 *   |                                                    | 
|POLY 1.5           |     P=0.019 *    P=0.106      P=0.179      P=0.022 *   |                                                    | 
|POLY 6             |     P=0.014 *    P=0.113      P=0.187      P=0.022 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.076      P=0.103      P=0.007 **  |                                                    | 
|COCH-ARM / FISHERS |     P=0.108      P=0.194      P=0.194      P=0.117     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   6/50 (12%)   6/50 (12%)  |12/50 (24%)  6/50 (12%)   7/50 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/44.63      5/43.96      6/43.48      6/41.73     |12/45.36     6/46.19      7/45.47      6/40.54      | 
|POLY-3 PERCENT (g) |     9.0%         11.4%        13.8%        14.4%       |26.5%        13.0%        15.4%        14.8%        | 
|TERMINAL (d)       |     4/37 (11%)   4/35 (11%)   4/33 (12%)   5/30 (17%)  |12/37 (32%)  4/39 (10%)   7/41 (17%)   5/31 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      634          663          620         |729 (T)      671          729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      P=0.471      P=0.309      P=0.253     |P=0.191N     P=0.078N     P=0.096N     P=0.180N     | 
|POLY 3             |     P=0.261      P=0.490      P=0.353      P=0.327     |P=0.155N     P=0.086N     P=0.149N     P=0.144N     | 
|POLY 1.5           |     P=0.275      P=0.490      P=0.361      P=0.340     |P=0.139N     P=0.090N     P=0.149N     P=0.126N     | 
|POLY 6             |     P=0.245      P=0.494      P=0.343      P=0.315     |P=0.171N     P=0.081N     P=0.149N     P=0.162N     | 
|LOGISTIC REGRESSION|     P=0.249      P=0.486      P=0.331      P=0.302     |P=0.199N     P=0.085N     P=0.096N     P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.306      P=0.500      P=0.370      P=0.370     |P=0.111N     P=0.096N     P=0.154N     P=0.096N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.63      1/43.62      0/43.01      4/41.64     |1/45.36      1/45.94      0/45.47      1/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         9.6%        |2.2%         2.2%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/37 (3%)    1/35 (3%)    0/33 (0%)    3/30 (10%)  |1/37 (3%)    1/39 (3%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          651         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    P=0.749      P=0.523N     P=0.131     |P=0.655      P=0.750N     P=0.480N     P=0.722      | 
|POLY 3             |     P=0.055      P=0.756      P=0.507N     P=0.158     |P=0.620N     P=0.758N     P=0.500N     P=0.734      | 
|POLY 1.5           |     P=0.057      P=0.756      P=0.504N     P=0.164     |P=0.619N     P=0.759N     P=0.499N     P=0.743      | 
|POLY 6             |     P=0.053      P=0.756      P=0.512N     P=0.152     |P=0.621N     P=0.757N     P=0.500N     P=0.725      | 
|LOGISTIC REGRESSION|     P=0.049 *    P=0.749      (e)          P=0.152     |P=0.655      P=0.750N     (e)          P=0.722      | 
|COCH-ARM / FISHERS |     P=0.062      P=0.753N     P=0.500N     P=0.181     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   6/50 (12%)   9/50 (18%)  |13/50 (26%)  7/50 (14%)   7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     5/44.63      6/43.96      6/43.48      9/42.02     |13/45.36     7/46.19      7/45.47      7/40.54      | 
|POLY-3 PERCENT (g) |     11.2%        13.7%        13.8%        21.4%       |28.7%        15.2%        15.4%        17.3%        | 
|TERMINAL (d)       |     5/37 (14%)   5/35 (14%)   4/33 (12%)   7/30 (23%)  |13/37 (35%)  5/39 (13%)   7/41 (17%)   6/31 (19%)   | 
|FIRST INCIDENCE    |     729 (T)      634          663          620         |729 (T)      671          729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072      P=0.466      P=0.429      P=0.105     |P=0.200N     P=0.084N     P=0.060N     P=0.200N     | 
|POLY 3             |     P=0.115      P=0.489      P=0.482      P=0.158     |P=0.159N     P=0.093N     P=0.100N     P=0.160N     | 
|POLY 1.5           |     P=0.124      P=0.489      P=0.491      P=0.168     |P=0.142N     P=0.098N     P=0.100N     P=0.139N     | 
|POLY 6             |     P=0.107      P=0.493      P=0.471      P=0.150     |P=0.175N     P=0.088N     P=0.100N     P=0.180N     | 
|LOGISTIC REGRESSION|     P=0.102      P=0.484      P=0.456      P=0.141     |P=0.210N     P=0.092N     P=0.060N     P=0.219N     | 
|COCH-ARM / FISHERS |     P=0.143      P=0.500      P=0.500      P=0.194     |P=0.113N     P=0.105N     P=0.105N     P=0.105N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.63      1/43.62      1/43.44      0/41.35     |0/45.36      0/45.94      2/46.19      1/40.39      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |0.0%         0.0%         4.3%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    0/39 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      606          ---         |---          ---          476          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.623N     P=0.489      P=0.496      (e)         |P=0.208      (e)          P=0.256      P=0.465      | 
|POLY 3             |     P=0.615N     P=0.495      P=0.495      (e)         |P=0.199      (e)          P=0.241      P=0.477      | 
|POLY 1.5           |     P=0.609N     P=0.496      P=0.497      (e)         |P=0.215      (e)          P=0.241      P=0.485      | 
|POLY 6             |     P=0.622N     P=0.495      P=0.491      (e)         |P=0.185      (e)          P=0.242      P=0.470      | 
|LOGISTIC REGRESSION|     P=0.588N     P=0.489      P=0.496      (e)         |P=0.289      (e)          P=0.186      P=0.465      | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.246      (e)          P=0.247      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/50 (28%)  11/50 (22%)  9/50 (18%)   13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |14/46.78     11/47.45     9/46.77      13/42.10     | 
|POLY-3 PERCENT (g) |                                                        |29.9%        23.2%        19.2%        30.9%        | 
|TERMINAL (d)       |                                                        |11/37 (30%)  8/39 (21%)   7/41 (17%)   11/31 (36%)  | 
|FIRST INCIDENCE    |                                                        |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.417      P=0.287N     P=0.129N     P=0.482      | 
|POLY 3             |                                                        |P=0.491      P=0.306N     P=0.168N     P=0.553      | 
|POLY 1.5           |                                                        |P=0.530      P=0.311N     P=0.167N     P=0.582N     | 
|POLY 6             |                                                        |P=0.451      P=0.302N     P=0.170N     P=0.504      | 
|LOGISTIC REGRESSION|                                                        |P=0.453N     P=0.328N     P=0.175N     P=0.532N     | 
|COCH-ARM / FISHERS |                                                        |P=0.489N     P=0.322N     P=0.171N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/50 (28%)  11/50 (22%)  10/50 (20%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |14/46.78     11/47.45     10/47.21     13/42.10     | 
|POLY-3 PERCENT (g) |                                                        |29.9%        23.2%        21.2%        30.9%        | 
|TERMINAL (d)       |                                                        |11/37 (30%)  8/39 (21%)   7/41 (17%)   11/31 (36%)  | 
|FIRST INCIDENCE    |                                                        |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.404      P=0.287N     P=0.190N     P=0.482      | 
|POLY 3             |                                                        |P=0.475      P=0.306N     P=0.231N     P=0.553      | 
|POLY 1.5           |                                                        |P=0.516      P=0.311N     P=0.233N     P=0.582N     | 
|POLY 6             |                                                        |P=0.436      P=0.302N     P=0.229N     P=0.504      | 
|LOGISTIC REGRESSION|                                                        |P=0.455N     P=0.328N     P=0.248N     P=0.532N     | 
|COCH-ARM / FISHERS |                                                        |P=0.500N     P=0.322N     P=0.241N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.19      1/43.62      0/43.01      2/41.72     |0/45.36      1/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         0.0%         4.8%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          729 (T)      ---          643         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.749      P=0.509N     P=0.469     |P=0.597N     P=0.511      (e)          (e)          | 
|POLY 3             |     P=0.350      P=0.753      P=0.510N     P=0.472     |P=0.568N     P=0.503      (e)          (e)          | 
|POLY 1.5           |     P=0.356      P=0.755      P=0.505N     P=0.481     |P=0.568N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.343      P=0.751      P=0.516N     P=0.463     |P=0.568N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.381      P=0.750N     P=0.521N     P=0.536     |(e)          P=0.511      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.61      1/43.62      0/43.01      2/41.72     |0/45.36      1/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         0.0%         4.8%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |0/37 (0%)    1/39 (3%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     554          729 (T)      ---          643         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553      P=0.514N     P=0.250N     P=0.661     |P=0.597N     P=0.511      (e)          (e)          | 
|POLY 3             |     P=0.574      P=0.516N     P=0.250N     P=0.662     |P=0.568N     P=0.503      (e)          (e)          | 
|POLY 1.5           |     P=0.580      P=0.511N     P=0.244N     P=0.672     |P=0.568N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.566      P=0.520N     P=0.259N     P=0.650     |P=0.568N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.615      P=0.472N     P=0.240N     P=0.655N    |(e)          P=0.511      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.591      P=0.500N     P=0.247N     P=0.691N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  14/50 (28%)  9/50 (18%)   17/50 (34%) |10/50 (20%)  11/50 (22%)  5/50 (10%)   16/50 (32%)  | 
|POLY-3 RATE (b)    |     11/46.82     14/46.02     9/44.61      17/44.18    |10/46.45     11/46.24     5/46.29      16/41.92     | 
|POLY-3 PERCENT (g) |     23.5%        30.4%        20.2%        38.5%       |21.5%        23.8%        10.8%        38.2%        | 
|TERMINAL (d)       |     5/37 (14%)   8/35 (23%)   4/33 (12%)   8/30 (27%)  |5/37 (14%)   8/39 (21%)   3/41 (7%)    10/31 (32%)  | 
|FIRST INCIDENCE    |     554          371          483          350         |554          671          536          601          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079      P=0.306      P=0.489N     P=0.081     |P=0.048 *    P=0.545      P=0.120N     P=0.064      | 
|POLY 3             |     P=0.101      P=0.303      P=0.448N     P=0.091     |P=0.069      P=0.495      P=0.131N     P=0.067      | 
|POLY 1.5           |     P=0.114      P=0.307      P=0.425N     P=0.103     |P=0.079      P=0.498      P=0.129N     P=0.083      | 
|POLY 6             |     P=0.089      P=0.297      P=0.480N     P=0.081     |P=0.062      P=0.492      P=0.134N     P=0.058      | 
|LOGISTIC REGRESSION|     P=0.155      P=0.341      P=0.385N     P=0.140     |P=0.074      P=0.507      P=0.133N     P=0.081      | 
|COCH-ARM / FISHERS |     P=0.142      P=0.322      P=0.402N     P=0.133     |P=0.109      P=0.500      P=0.131N     P=0.127      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.75      1/43.62      1/43.39      0/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         2.3%         2.3%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     699          729 (T)      624          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.198N     P=0.220N     P=0.094N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.036N*    P=0.186N     P=0.188N     P=0.071N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.035N*    P=0.185N     P=0.183N     P=0.067N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.037N*    P=0.187N     P=0.194N     P=0.075N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.186N     P=0.185N     P=0.078N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.181N     P=0.181N     P=0.059N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.75      1/43.62      1/43.39      0/41.35     |1/45.36      0/45.94      0/45.47      0/40.39      | 
|POLY-3 PERCENT (g) |     8.9%         2.3%         2.3%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/35 (3%)    0/33 (0%)    0/30 (0%)   |1/37 (3%)    0/39 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     699          729 (T)      624          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.198N     P=0.220N     P=0.094N    |P=0.321N     P=0.489N     P=0.480N     P=0.535N     | 
|POLY 3             |     P=0.036N*    P=0.186N     P=0.188N     P=0.071N    |P=0.293N     P=0.497N     P=0.500N     P=0.523N     | 
|POLY 1.5           |     P=0.035N*    P=0.185N     P=0.183N     P=0.067N    |P=0.298N     P=0.499N     P=0.499N     P=0.515N     | 
|POLY 6             |     P=0.037N*    P=0.187N     P=0.194N     P=0.075N    |P=0.288N     P=0.496N     P=0.500N     P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.186N     P=0.185N     P=0.078N    |P=0.321N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.181N     P=0.181N     P=0.059N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  47/50 (94%)  49/50 (98%)  46/50 (92%) |45/50 (90%)  45/50 (90%)  43/50 (86%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     48/49.05     47/47.26     49/49.29     46/46.37    |45/48.50     45/49.11     43/47.88     44/46.15     | 
|POLY-3 PERCENT (g) |     97.9%        99.5%        99.4%        99.2%       |92.8%        91.6%        89.8%        95.3%        | 
|TERMINAL (d)       |     36/37 (97%)  35/35 (100%) 33/33 (100%) 30/30 (100%)|34/37 (92%)  35/39 (90%)  38/41 (93%)  30/31 (97%)  | 
|FIRST INCIDENCE    |     479          509          364          496         |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.107      P=0.492      P=0.186      P=0.166     |P=0.109      P=0.419N     P=0.156N     P=0.150      | 
|POLY 3             |     P=0.467      P=0.591      P=0.592      P=0.638     |P=0.374      P=0.567N     P=0.433N     P=0.461      | 
|POLY 1.5           |     P=0.677      P=0.711      P=0.609      P=0.791     |P=0.497      P=0.591N     P=0.386N     P=0.572      | 
|POLY 6             |     P=0.320      P=0.519      P=0.532      P=0.529     |P=0.292      P=0.538N     P=0.514N     P=0.392      | 
|LOGISTIC REGRESSION|     P=0.562      P=0.692      P=0.534      P=0.693     |P=0.366      P=0.619N     P=0.326N     P=0.404      | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.500N     P=0.500      P=0.339N    |P=0.397N     P=0.630N     P=0.380N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/01                           EXPERIMENT: 93023 TEST: 06                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   2,4-HEXADIENAL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  23/50 (46%)  24/50 (48%)  30/50 (60%) |18/50 (36%)  19/50 (38%)  14/50 (28%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     21/49.07     23/46.83     24/46.67     30/45.67    |18/47.24     19/47.82     14/48.30     21/42.76     | 
|POLY-3 PERCENT (g) |     42.8%        49.1%        51.4%        65.7%       |38.1%        39.7%        29.0%        49.1%        | 
|TERMINAL (d)       |     10/37 (27%)  14/35 (40%)  13/33 (39%)  18/30 (60%) |10/37 (27%)  12/39 (31%)  8/41 (20%)   13/31 (42%)  | 
|FIRST INCIDENCE    |     259          371          483          350         |511          347          476          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.381      P=0.254      P=0.028 *   |P=0.166      P=0.556      P=0.227N     P=0.167      | 
|POLY 3             |     P=0.014 *    P=0.339      P=0.261      P=0.019 *   |P=0.223      P=0.519      P=0.234N     P=0.200      | 
|POLY 1.5           |     P=0.019 *    P=0.358      P=0.290      P=0.025 *   |P=0.256      P=0.515      P=0.240N     P=0.240      | 
|POLY 6             |     P=0.011 *    P=0.326      P=0.234      P=0.014 *   |P=0.204      P=0.522      P=0.229N     P=0.176      | 
|LOGISTIC REGRESSION|     P=0.042 *    P=0.452      P=0.386      P=0.064     |P=0.336      P=0.498      P=0.268N     P=0.247      | 
|COCH-ARM / FISHERS |     P=0.038 *    P=0.420      P=0.344      P=0.055     |P=0.345      P=0.500      P=0.260N     P=0.341      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            22.5         45           90          |0            22.5         45           90           | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 48/50 (96%)  50/50 (100%) 47/50 (94%) |47/50 (94%)  48/50 (96%)  48/50 (96%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     50/50.00     48/48.12     50/50.00     47/47.26    |47/49.06     48/50.00     48/49.29     44/46.15     | 
|POLY-3 PERCENT (g) |     100.0%       99.7%        100.0%       99.5%       |95.8%        96.0%        97.4%        95.3%        | 
|TERMINAL (d)       |     37/37 (100%) 35/35 (100%) 33/33 (100%) 30/30 (100%)|35/37 (95%)  37/39 (95%)  40/41 (98%)  30/31 (97%)  | 
|FIRST INCIDENCE    |     259          371          364          350         |445          346          476          363          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.142      P=0.567      (e)          P=0.215     |P=0.196      P=0.488N     P=0.350N     P=0.246      | 
|POLY 3             |     P=0.940N     P=1.000N     (e)          P=1.000N    |P=0.571N     P=0.676      P=0.551      P=0.663N     | 
|POLY 1.5           |     P=0.295N     P=0.935N     (e)          P=0.642N    |P=0.365N     P=0.642      P=0.562      P=0.485N     | 
|POLY 6             |     P=1.000N     P=1.000N     (e)          P=1.000N    |P=0.485      P=0.685      P=0.518      P=0.639      | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.336N     (e)          P=0.211N    |P=0.339N     P=0.511      P=0.586      P=0.585N     | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.247N     (e)          P=0.121N    |P=0.113N     P=0.500      P=0.500      P=0.243N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.